TW202200007A - Insecticide composition excellent in stability by suppressing the generation of separation and precipitation during storage - Google Patents

Abstract

This invention aims to provide an insecticide composition excellent in stability by suppressing the generation of separation or precipitation during storage while being an aqueous formulation using water as a solvent. The solution is an insecticide composition containing (A) an insecticidal component, (B) a surfactant, (C) an additive and (D) water, wherein the (C) additive is one or more selected from the group consisting of an organic acid salt, an alkaline agent, an inorganic salt and a chelating agent. The (A) insecticidal component is preferable to contain at least a pyrethroid-based compound.

Description

Insecticide composition

The present invention relates to an insecticide composition containing an insecticidal component, and more specifically, to an aqueous insecticide composition using water as a solvent.

When prescribing the insecticidal ingredient of an organic compound as an insecticide composition, the water-based formulation using water as the solvent is safer than the formulation that dissolves the insecticidal ingredient in an organic solvent, and it is easy to diffuse and kill. The advantages of insect ingredients.

Therefore, in the production of the insecticide composition, a method of dispersing the insecticidal component in water and making it solubilized using a surfactant is generally adopted. However, water-based formulations may cause separation or precipitation due to storage conditions after the production of the insecticide composition. When separation or precipitation of the pesticide composition occurs, there is a possibility that the intended effect cannot be exhibited. In order to solve such a subject, as disclosed in patent document 1, the method of improving the stability of an insecticide composition by blending an organic solvent as a stabilizer is performed. [Prior Art Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. 2013-95744

[The problem to be solved by the invention]

However, it is known that when an organic solvent is applied to a material such as plastic, it causes deterioration or deterioration, and further causes cracking and the like. Therefore, when an organic solvent is blended as a stabilizer, there is a problem that it cannot be used depending on the material of the drug treatment object. In addition, since the ignition point of the pesticide composition is lowered depending on the type or amount of the organic solvent, the risk as a product may increase.

Therefore, in view of the above-mentioned problems, the present invention aims to provide an aqueous formulation using water as a solvent, and an insecticide composition excellent in stability against occurrence of separation or precipitation during storage. [means to solve the problem]

In order to achieve the above object, as an aspect of the present invention, there is provided an insecticide composition comprising (A) an insecticidal component, (B) a surfactant, (C) an additive and (D) water, the aforementioned (C) An additive is 1 or more types selected from the group which consists of an organic acid salt, an alkali agent, an inorganic salt, and a chelating agent.

The above-mentioned (A) insecticidal component can be defined as a pyrethrin-based compound.

The blending amount of the aforementioned (B) surfactant can be determined as the state after the composition blended with the aforementioned (A), (B) and (D) without blending (C) is allowed to stand at 20°C for 24 hours. Quantity that neither isolated nor precipitated. [Inventive effect]

According to one aspect of the present invention, since it is an aqueous formulation using water as a solvent and a prescribed additive is blended, even if an organic solvent as a stabilizer is not blended, separation or precipitation during storage can be suppressed. The resulting insecticide composition with excellent stability.

Hereinafter, embodiments of the present invention will be described. It should be noted that the embodiments described below are only examples of embodying the present invention, and are not intended to limit the technical scope of the present invention. The insecticide composition of this embodiment is an insecticide composition containing (A) an insecticidal ingredient, (B) a surfactant, (C) an additive and (D) water, and the aforementioned (C) additive is selected as the One or more of the group consisting of free organic acid salts, alkali agents, inorganic salts and chelating agents.

As the (A) insecticidal component in this embodiment, an organic compound having insecticidal activity is used. For example, Allethrin, Prallethrin, Phthalthrin, Transfluthrin, Metofluthrin, Profluthrin, Cyclopentyl Terallethrin, Furamethrin, Momfluorothrin, Dimefluthrin, Meperfluthrin, Dexfluthrin Heptafluthrin, Phenothrin, Cyphenothrin, permethrin, Cypermethrin, Cyfluthrin, Bifenthrin, Fenpropathrin ), Deltametrin, Tralomethrin, Imiprothrin, Resmethrin, Pyrethrin, Silafluofen (also an organosilicon series) Insecticides), pyrethroid compounds such as Etofenprox, organophosphorus such as Fenitrothion, Diazinon, Propaphos, Propoxur, Carbamates such as Metoxadiazone, Cartap, Buprofezin, etc.

These insecticidal ingredients may be used alone or in combination of two or more. Among the above-mentioned insecticidal ingredients, from the viewpoint of low toxicity to warm-blooded animals and high safety to human body, pyrethrin-based compounds are preferably used, and more preferably Efenin, Siprofen, and Saifu are used. Pyrethrin compounds with m-phenoxybenzyl skeleton such as pyrethrin, phenoxybenzyl, cyphenidin, permethrin, cyphenin, fenpronin, dimenin, taimenin, etc., or Fuling, Metinine, Profluthrin, Difluthrin, Transfluthrin, Chlorfluthrin, Dexfluthrin, etc. have 2,3,5,6-tetrafluoromethrin For the pyrethrin-based compound having a fluorobenzyl skeleton, from the viewpoint of low fish toxicity, it is more preferable to use Efenine and Siprofen. (A) The blending amount of the insecticidal ingredient is preferably 0.1% by mass to 15% by mass, and more preferably 0.1% by mass with respect to the entire insecticide composition, considering the balance between the efficacy and the solubilization of the insecticidal ingredient. ~2 mass %, more preferably 0.1 mass % to 1 mass %.

As the (B) surfactant in this embodiment, any of an anionic surfactant, a cationic surfactant, and a nonionic surfactant can also be used. These surfactants may be used alone or in combination of two or more. More specifically, examples of the anionic surfactant include carboxylate, sulfonate, sulfate, and phosphate. As a cationic surfactant, an aliphatic amine salt, its quaternary ammonium salt, an aromatic quaternary ammonium salt, a heterocyclic quaternary ammonium salt, etc. are mentioned.

Examples of the nonionic surfactant include ether-type nonionic interfaces such as polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene polyoxypropylene alkyl ether, and polyoxyethylene alkyl amino ether. Active agent, or ether ester type nonionic surfactant of polyoxyethylene glycerin fatty acid ester, polyoxyethylene hardened castor oil, polyoxyethylene sorbitan fatty acid ester, etc., or polyethylene glycol fatty acid ester, fatty acid mono Ester-type nonionic surfactants such as acid glycerides, polyglycerol fatty acid esters and sorbitan fatty acid esters.

When a pyrethrin-based compound is used as the (A) insecticidal component, as a nonionic surfactant, the HLB value is desirably 9.0 or more. Thereby, the storage stability of an insecticide composition can be improved. In this specification, the so-called HLB value means a hydrophilic-lipophilic balance (Hydrophilic-Lipophilic Balance) value, and is set to a value from 0 to 20. The closer to 0, the higher the lipophilicity, and the closer to 20, the higher the hydrophilicity.

As the (C) additive in this embodiment, one or more kinds selected from organic acid salts, alkali agents, inorganic salts, and chelating agents can be used. Examples of organic acid salts include citrate, lactate, fumarate, gluconate, acetate, and succinate. As an alkali agent, bicarbonate, triethanolamine, metal hydroxide, etc. are mentioned. As an inorganic salt, a sulfate metal salt, a metal salt compound, etc. are mentioned. In the case of any one of an organic acid salt, an alkali agent, and an inorganic salt, the type of the salt is preferably a sodium salt or a potassium salt. In this specification, the so-called chelating agent refers to a compound that coordinates with a metal ion to form a chelate (complex), for example, metal salts of ethylenediaminetetraacetic acid (EDTA), ethylenediamine-N, Metal salts of N'-disuccinic acid (EDDS), etc.

(B) The blending amount of the surfactant is not particularly limited, and it can be set as any one of separation and precipitation after the composition blended with (A)~(D) is left standing at room temperature (20°C) for 24 hours. amount not produced. However, as the blending amount of the surfactant (B), it is preferable to blend the composition of (A), (B) and (D) without blending (C) after standing at 20°C for 24 hours. It is the amount that neither separation nor precipitation occurs. Thereby, it becomes possible to ensure the stability of the insecticide composition at room temperature by blending the surfactant. By blending the additive (C) therewith, the stability of the insecticide composition against temperature changes can be further improved. When the stability of the pesticide composition is described in detail, especially when the pesticide composition is stored at low temperature, separation and precipitation of the pesticide composition are likely to occur, and the pesticide composition can be inhibited by blending additives. The separation of components, the generation of precipitation, etc. Specifically, (B) surfactant/(A) insecticidal component (mass ratio) is preferably 5 or more, more preferably 5 to 100.

With respect to the blending amount of the (B) surfactant in the entire insecticide composition, the smaller the amount, the lower the cost and the lower the load on the environment. From this viewpoint, the blending amount of the surfactant (B) can be determined so that the composition without blending (C) in which the aforementioned (A), (B) and (D) are blended is allowed to stand at 20° C.×24 The state after one hour was that neither separation nor precipitation occurred, and the state after leaving the composition not blended with (C) at 5°C for 24 hours was the amount of separation or precipitation. Specifically, (B) surfactant/(A) insecticidal component (mass ratio) is preferably 5 to 40.

Thereby, the compounding quantity of (B) surfactant can be suppressed. In addition to this, the blending amount of the additive (C) can be set to the amount that neither separation nor precipitation occurs in the state after the insecticide composition is allowed to stand at 5°C for 24 hours. Specifically, the compounding amount of the additive (C) is preferably 0.1% by mass to 60% by mass, more preferably 0.1% by mass to 30% by mass, and still more preferably 0.1% by mass, based on the entire insecticide composition. ~10% by mass. Furthermore, the blending amount of the surfactant (B) can be defined as an amount that does not cause separation or precipitation after the composition not blended with (C) is allowed to stand at 5°C for 24 hours. Even if the blending amount of the surfactant is an amount that does not cause separation or precipitation after the pesticide composition is allowed to stand at 5°C for 24 hours, the blending of the additive can further improve the pesticide composition. Low temperature stability.

As described above, in the preparation method of the insecticide composition containing the (A) insecticidal component, (B) surfactant, (C) additive and (D) water, the above (A) and (B) And (D) the composition without the above-mentioned (C) was left standing at 20°C for a certain period of time in the state that neither separation nor precipitation occurred. ℃ lower than the designated temperature for a certain period of time, the state will cause separation or precipitation, adjust the blending amount of the aforementioned (B) surfactant, and blend the aforementioned (A)~(D) pesticides The state of the composition after standing for a certain period of time at the above-mentioned designated temperature is a form in which neither separation nor precipitation occurs, and the blending amount of the above-mentioned (C) additive can be adjusted.

The insecticide composition thus prepared suppresses the blending amount of the surfactant (B), and exhibits an excellent effect of low temperature stability (stability at a predetermined temperature lower than 20°C). Here, the so-called designated temperature lower than 20° C. can be appropriately set according to the predetermined storage environment of the insecticide composition. Specifically, it can be set at 0°C to 10°C, for example, so as to generate a temperature difference from 20°C to some extent.

In addition, the so-called fixed period of time is preferably a period of time during which the insecticide composition is allowed to stand still and its stability is determined, and can be set, for example, from 12 hours to 24 hours. Empirically, since the appearance of the insecticide composition when the insecticide composition is left to stand for 24 hours is at the same level as the appearance when the time to stand is extended, it can be set to about 24 hours.

As mentioned above, the insecticide composition of the present invention is at 20° C. (room temperature), although neither separation nor precipitation occurs, but it is preferably transparent, thereby improving the performance of the post-manufacturing process. The stability of external changes such as changes in temperature. From this viewpoint, it is more preferable that the insecticide composition of the present invention is transparent even at a lower temperature than 20°C (eg, 5°C). Also, here, "transparent" means that the absorbance at a wavelength of 500 nm is less than 1.0.

The pesticide composition of the present invention is an aqueous formulation using water as a solvent, and a prescribed additive is blended, so even if the organic solvent as a stabilizer is not blended, the pesticide composition will not be stored during storage of the pesticide composition. It can inhibit the generation of separation or precipitation. However, in the range which does not impair the effect of this invention, you may mix|blend an organic solvent with an insecticide composition. In other words, the organic solvent may not be contained substantially.

That is, even in the case of applying the insecticide composition to plastic, there is no problem even if it contains an organic solvent to such an extent that deterioration, deterioration, cracking, etc. of the plastic does not occur. Specifically, the blending amount of the organic solvent may be 20% by mass or less, more preferably 10% by mass or less, relative to the entire insecticide composition. Moreover, if necessary, in the aqueous insecticide composition of this invention, in the range which does not impair the effect of this invention, a fragrance|flavor, a deodorant, a sterilizing agent, a coloring matter, etc. may be mix|blended. [Example]

Hereinafter, the present invention will be described in detail with reference to Examples. However, the present invention is not limited to these embodiments.

[Evaluation of Nonionic Surfactants] When adjusting the insecticide composition, first, a test is carried out with respect to the relationship between the HLB value and the stability of the insecticide composition when a nonionic surfactant is used as the (B) surfactant (refer to Test 1 to Table 1). 5). Furthermore, Efenin, a pyrethrin-based compound, is used as (A) an insecticidal component, and as (B) a surfactant, polyoxyethylene hardened castor oil is used, and ethylene oxide (EO) 5 kinds of nonionic surfactants with different average added moles.

Next, using polyoxyethylene hardened castor oil with an HLB value of 13.1 as the (B) surfactant, the relationship between the mass ratio of the surfactant compounding amount/the compounding amount of the insecticidal component and the stability of the insecticide composition , carry out the test (tests 6 to 11 in Table 1). However, in this test, (C) additive was not blended, (A) insecticidal ingredient, (B) surfactant and water were blended to make an insecticide composition, which would be killed after standing at a specified temperature for 24 hours. The appearance of the insecticide composition was evaluated visually. The evaluation criteria are as follows. ⊚: The insecticide composition is colorless and transparent (the absorbance at a wavelength of 500 nm is less than 1.0). ○: Although the insecticide composition was in a translucent or cloudy state, separation or precipitation was not observed. Furthermore, the term "translucent or cloudy" here means that the absorbance at a wavelength of 500 nm is 1.0 or more. ×: Separation or precipitation was observed in the insecticide composition.

The evaluation results of the nonionic surfactant are recorded in Table 1. From Table 1, in the case of a nonionic surfactant, if the HLB value is 9.0 or more, even if the insecticide composition is left to stand at 20°C for 24 hours, it can be formulated without causing separation or precipitation. Therefore, in the following examples, evaluation was performed using a nonionic surfactant having an HLB value of 9.0 or more.

[Preparation of insecticide composition] An insecticide composition is prepared by blending (A) an insecticide component, (B) a surfactant, (C) an additive, and (D) water. The following nonionic surfactants, anionic surfactants, and cationic surfactants were used as the (A) insecticidal component and as the (B) surfactant, Efenine was used.

(1) Nonionic surfactant ･Polyoxyethylene hardened castor oil (EO average added molar 40) ･Polyoxyethylene lauryl ether (EO average added molar number 9) ･Polyoxyethylene styrylated phenyl ether (2) Anionic surfactants ･Ammonium polyoxyethylene styrylated phenyl ether sulfate (EO average added molar number 13) (3) Cationic surfactant ･Lauryldimethylbenzylammonium chloride

In the above (A) and (B), an organic acid salt was blended as an additive (C), and the stability of the pesticide composition was evaluated (Table 2, Examples 1 to 14). In addition, as a comparative example, the insecticide composition which did not mix|blend (C) additive was prepared and evaluated (Table 2, Comparative Examples 1-5). Furthermore, the pesticide composition in which the organic acid was blended as an additive (C) was prepared and evaluated (Table 2, Comparative Example 6). Furthermore, the evaluation of the stability of the insecticide composition is carried out according to the evaluation criteria of the aforementioned "Evaluation of Nonionic Surfactant". The evaluation results are recorded in Table 2.

Moreover, the insecticide composition prepared in the said (A) and (B), and an inorganic salt or an alkali agent as an additive (C) was mixed, and the stability was evaluated (Table 3, Examples 15-28). Furthermore, the insecticide composition prepared in the above (A) and (B) and blended with a chelating agent as an additive (C) is based on the evaluation criteria of the aforementioned "Evaluation of Nonionic Surfactant" for its stability. Evaluation (Table 4, Examples 29-37).

(A) As an insecticidal component, an insecticide composition was prepared by using Metternine or Saifenin instead of Efenine, and the stability was evaluated (Table 5, Examples 38 to 39, Comparative Examples 7 to 8). Still, in Table 5, as (B) surfactant, polyoxyethylene hardened castor oil (EO average added molar number 40) of nonionic surfactant is used, and as (C) additive, organic acid salt is used of sodium citrate.

[evaluation result] As shown in Tables 2 to 4, it was found that the pesticide compositions (Examples 1 to 39) in which various surfactants and various additives were blended were combined, and the compositions without (C) additives were blended (comparison). Compared with Example 1 to Comparative Example 8), the low temperature stability was improved. Thereby, since the usage-amount can be reduced with respect to the surfactant which has high solubilizing power and can solubilize an insecticidal component even if it is independent, it becomes possible to reduce cost.

In addition, as represented by cationic surfactants having a sterilizing effect, for surfactants with known effects other than the solubilizing effect, since the solubilizing power is insufficient, there are cases where it cannot be used alone. By blending the additives, it becomes a soluble insecticide composition, and a secondary effect can be obtained.

The metrinin used as the (A) insecticidal ingredient is a normal temperature volatile insecticidal ingredient. Here, the so-called volatility at room temperature means that the vapor pressure at 30°C is 2×10 ^-4 to 1×10 ^-2 mmHg. Efenin and Saifenin are refractory insecticidal ingredients whose vapor pressure at 30℃ is less than 2×10 ^-4 mmHg. From Examples 1, 38, and 39, it was confirmed that the (A) insecticidal component may be either a normal temperature volatile insecticidal component or a hardly volatile insecticidal component.

The embodiments of the present invention have been described above, but the scope of the present invention is not limited thereto, and various modifications can be added and implemented without departing from the gist of the invention. For example, in Tables 2 to 5, (A) insecticidal ingredients, (B) surfactants, and (C) additives are blended for each type of combination, but not limited to this, for (A) to (C) ) at least one of them, and plural types may also be used. The constituent elements disclosed in the embodiments and the examples can be combined with each other, and new technical features can be formed by combining them.

Claims (3)

An insecticide composition, which is an insecticide composition containing (A) an insecticidal ingredient, (B) a surfactant, (C) an additive and (D) water, characterized in that the aforementioned (C) additive is selected from One or more of the group consisting of free organic acid salts, alkali agents, inorganic salts and chelating agents. The insecticide composition according to claim 1, wherein the (A) insecticidal component contains at least a pyrethrin-based compound. The pesticide composition according to claim 1 or 2, wherein the blending amount of the surfactant (B) is to blend the (A), (B) and (D) without blending the aforementioned (C) The state of the composition after standing at 20°C for 24 hours is an amount in which neither separation nor precipitation occurs.