TW202042860A - Ultrasonic image diagnostic device, and device for treating underarm odor or excessive perspiration - Google Patents

Abstract

Provided is an ultrasonic image diagnostic device for visualizing and displaying a subcutaneous state, and a device for treating underarm odor or excessive perspiration provided with the ultrasonic image diagnostic device. An ultrasonic image diagnostic device pertaining to an embodiment of the present invention is an ultrasonic image diagnostic device having an ultrasonic probe 11, a cross-sectional echo image generating device 13, and an analysis device 14 for analyzing the cross-sectional echo image and recognizing a sweat gland, wherein the ultrasonic probe 11 has a substantially rectangular contact surface 11a having long sides and short sides, and is capable of scanning in at least the long-side direction and the short-side direction, the cross-sectional echo image generating device 13 displays a cross-sectional echo image on the basis of a scanning signal obtained by length-direction scanning and short-side-direction operation of the ultrasonic probe 11 on the epidermal surface of an organism, and the analysis device 14 obtains and displays information relating to a distribution state, position, and depth, and information relating to the position, state of spread, invasion depth, and degree of infiltration of a malignant skin tumor on the basis of the cross-sectional echo image.

Description

Ultrasonic image diagnosis device and treatment device for body odor or hyperhidrosis

The present invention relates to an effective preoperative diagnosis, postoperative diagnosis, and recurrence diagnosis of sweat glands, namely exocrine glands or apocrine glands, which exist under the skin of the human body, and visually display information related to the distribution state, density, position and depth or skin benign, An ultrasonic imaging diagnostic device for the diagnosis, location, spreading state, depth and infiltration of malignant tumors, and a treatment device for body odor or hyperhidrosis equipped with the ultrasonic imaging diagnostic device.

Exocrine glands are sweat glands that almost exist in the skin of the whole body, especially in the head, face, and back in large numbers. Almost all human sweat comes from this exocrine gland. Most of the sweat from this exocrine gland is water, and the main component other than water is salt. In contrast, the apocrine glands are sweat glands especially present in the armpits, ears, areola, or genitals. The sweat from the apocrine glands contains 70 to 80% of water, protein, lipids, ammonia, and the like. Sweat from the apocrine glands is the cause of unpleasant odors such as so-called underarm odor (body odor).

Since the secretion of excess sweat from these apocrine glands or exocrine glands causes underarm odor (bristle odor) or hyperhidrosis, treatment methods to suppress excess sweating have been studied previously. For example, Patent Document 1 discloses a publication suppression device including an electrode needle and a cooling part formed with a through hole through which the electrode needle can be inserted, and the cooling part is brought into close contact with the skin surface of a living body , The electrode needle is protruded from the cooling part and energized, and the front end of the electrode needle is heated, thereby destroying the sweat gland on the front end of the electrode needle. By using this publication suppression device to destroy sweat glands, excess sweat secretion from apocrine or exocrine glands can be suppressed.

The sweat glands, which are the target of the publication suppression device, exist across the dermis to the subcutaneous tissue and exist at various depths, but the thickness of the dermis or subcutaneous tissue varies not only from person to person, but also from the location of the organism. Therefore, in order to reliably destroy the sweat glands, it is necessary to gradually change the puncture depth of the electrode needle according to the thickness of the dermis or subcutaneous tissue, and heat the entire depth from the dermis to the subcutaneous tissue.

However, the previous publication suppression device does not have a mechanism to detect the distribution or depth of the apocrine or exocrine glands of organisms (including the dermis and subcutaneous tissue, the same below), and therefore cannot grasp the range or depth of heating by the electrode. As a result, there is a risk of overheating or insufficient heating of the living body. Therefore, it is desired to confirm the location and depth of apocrine glands or exocrine glands in advance. In addition, in surgical methods such as resection or ablation, operations that do not grasp the scope or depth are directly performed.

In addition, the current diagnosis of skin cancer is due to the lack of diagnostic methods. The tissue is removed from the skin surface, and the pathological tissue is diagnosed after reaching the cancerous tissue, and the treatment of skin cancer is determined. In addition, when skin cancer does not appear in the superficial position, the original diagnosis method of cutting the tissue deeper to determine whether there is skin cancer is used. Therefore, it is desired to develop a mechanism that can visually display the state of the lower tissue in the depth direction from the skin surface, and confirm the location, spreading state, and depth of cancer. [Prior Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. 2017-086096 [Patent Document 2] Japanese Patent Laid-Open No. 2014-247054

[The problem to be solved by the invention]

On the other hand, as a mechanism for visualizing tissues inside a living body, methods and systems for ultrasonic tissue processing using ultrasonic probes are known. For example, Patent Document 2 discloses the following: when the fascia (SMAS: Superficial musculo-aponeurotic system, superficial musculo-aponeurotic system) of the face is contracted using an ultrasound imaging/treatment probe to perform facial plastic surgery, The ultrasound imaging/treatment probe visually displays the subcutaneous cross-sectional structure including the SMAS, and the SMAS is heated and contracted for shaping by supplying ultrasound energy from the ultrasound imaging/treatment probe. Furthermore, paragraphs [0051] to [0071] of Patent Document 2 also disclose the following: by using ultrasound imaging/therapeutic probes to visually display the subcutaneous structure of sweat glands including apocrine glands and exocrine glands, And by supplying ultrasonic energy from the ultrasonic imaging/treatment probe, the tissues are treated.

Moreover, in Patent Document 2, the paragraph "0062" discloses that "the imaging converter can be operated at a frequency of about 2 MHz～75 MHz or more, and the treatment can be performed at a frequency of about 500 kHz～15 MHz, usually 2 MHz～25 MHz. Introduce.” and the paragraph “0064” states “For example, as shown in FIG. 2B, according to a typical embodiment, a typical treatment method and system are configured to first image the region 222 in the region of interest 206, In order to facilitate the identification of the sweat gland 230 and the identification of the treatment part and surrounding structures, the area 224 is displayed on the display 208". In addition, an example of displaying sweat glands on the display part is shown in FIGS. 2P and 2Q.

In this way, although patent document 2 is temporarily approved for the description of the display of sweat glands by ultrasound imaging/treatment probes, in patent document 2, what configuration ultrasound imaging/treatment probes are used and what frequency is used The imaging of sweat glands and how to operate the ultrasound imaging/treatment probe for display are not clear. Since the exocrine glands or apocrine glands exist in the subcutaneous depth of only a few mm, such as 0.5-3.5 mm, it is difficult to obtain a clear cross-sectional echo image of the sweat glands with the previous ultrasonic probe. According to the inventors, this article Before the patent application, there was no example of using ultrasonic probes to obtain the cross-sectional echo images of sweat glands as shown in Figure 2P and Figure 2Q of Patent Document 2.

The present invention is completed to solve the problems of the prior art as described above. That is, the purpose of the present invention is to provide an ultrasonic probe that can visually display the sweat glands that exist under the skin of the human body, namely exocrine glands or apocrine glands or malignant tumors of the skin, and obtain the position, distribution and status of the detected sweat glands. Ultrasonic imaging diagnostic device with information related to the location, spreading state, and depth of malignant tumors of the depth or skin, and a treatment device for body odor or hyperhidrosis equipped with the ultrasonic imaging diagnostic device. In addition, malignant tumors of the skin include skin cancer or malignant melanoma. [Technical means to solve the problem]

The ultrasonic imaging diagnostic device of the first aspect of the present invention is characterized by having: Ultrasonic probe A cross-sectional echo image generating device, which generates a cross-sectional echo image by scanning signals from the above-mentioned ultrasonic probe; and An analysis device that analyzes the cross-sectional echo image from the above-mentioned cross-sectional echo image generating device to identify the subcutaneous state; and The above-mentioned ultrasonic probe includes a substantially rectangular contact surface with a long side and a short side, and can scan at least the long side direction and the short side direction; The cross-sectional echo image generating device displays cross-sectional echo images based on the scanning signals obtained by scanning the long-side direction and the short-side direction of the ultrasonic probe on the surface of the biological body's epidermis; The analysis device obtains and displays information related to the state below the epidermis of the organism based on the cross-sectional echo image.

According to the ultrasonic imaging diagnostic device of the first aspect of the present invention, since the ultrasonic probe has a substantially rectangular contact surface with a long side and a short side, and can scan in the long-side direction and the short-side direction, and The cross-sectional echo image generating device displays the cross-sectional echo image based on the scanning signal obtained by the above-mentioned ultrasonic probe on the surface of the biological body's epidermis by scanning in the long-side direction and the short-side direction. Profile echo image of its state. In addition, since the cross-sectional echo image shows the state below the biological body's epidermis well, the analysis device accurately recognizes the state below the biological body's epidermis and can accurately identify the range required for treatment.

In the ultrasonic imaging diagnostic device of this aspect, the state below the epidermis of the organism can be information related to the distribution state of sweat glands, information related to the location of sweat glands, information related to the depth of sweat glands, and location related to malignant tumors of the skin At least one of the information related to the spreading status of the skin malignant tumor, the depth of the skin malignant tumor, or the information related to the infiltration degree of the skin malignant tumor.

According to the ultrasonic imaging diagnostic device of this aspect, it is possible to easily confirm the distribution state, position and depth related information of the apocrine and exocrine glands, or the position, spreading state, depth and infiltration of skin malignant tumors Therefore, it is easy to treat body odor or hyperhidrosis or treat malignant skin tumors.

In the ultrasonic imaging diagnostic device of this aspect, it is preferable that the ultrasonic probe is a linear probe equipped with a row of ultrasonic driving elements, and the driving frequency is 20 MHz or more.

The higher the driving frequency of the ultrasonic probe system, the more the analysis performance can be improved, and the image of the part close to the skin surface can be obtained. Moreover, if the linear probe is used, the ultrasonic wave will not diffuse, so good image quality can be obtained. An echo image of the profile in a narrow range. In addition, the driving frequency of the ultrasonic probe is preferably above 30 MHz. In particular, if the driving frequency of the ultrasonic probe is set to 30 MHz or more, a clear image quality cross-sectional echo map can be obtained. Therefore, even if it is an animation, the position, depth and distribution of sweat glands or skin can be clearly identified The location, spreading state, depth and infiltration of the malignant tumor. In addition, in order to improve the resolution, the number of elements as a linear probe type ultrasonic probe is preferably 128 elements or more, more preferably 192 elements or more, and still more preferably 256 elements or more, specifically For example, about 200 elements, or for example, 400 to 600 elements or more may be used. The more components (the higher the component density), the higher the analysis performance.

In addition, in the ultrasonic imaging diagnostic device of this aspect, the analysis device can determine the measurement range by scanning the ultrasonic probe along the longitudinal direction. In the determined measurement range, the ultrasonic probe Scan in the direction along the short side to grasp the state of the organism below the epidermis.

According to the ultrasonic imaging diagnostic device of this aspect, since the ultrasonic probe includes a substantially rectangular contact surface with a long side and a short side, it can be adjusted by the direction of the ultrasonic probe along the long side. Scanning clearly judges the state of the organism below the epidermis, grasping the range required for treatment, and further, by scanning along the short side direction, a wide range of good cross-sectional echo images can be obtained, thereby diagnosing sweat glands Or the distribution or state of malignant tumors on the skin.

In addition, in the ultrasonic image diagnosis device of this aspect, it is preferable that the cross-sectional echo image generating device is one that can obtain a 3D ultrasonic echo image at a position below the epidermis of the biological body.

According to the ultrasonic imaging diagnostic device of this aspect, since the state of the body below the epidermis is accurately obtained, useless data such as 3D ultrasonic echo images of the position where sweat glands do not exist are reduced, and the cross-sectional echo image generating device and The processing burden of the analysis device.

Furthermore, in the ultrasonic imaging diagnostic device of this aspect, the cross-sectional echo image generating device preferably selects and displays at least one of the cross-sectional echo images before and after the anesthetic is injected under the epidermal surface of the living body. By.

According to the ultrasonic imaging diagnostic device of this aspect, since the ultrasonic echo image before treatment, the ultrasonic echo image after injection of anesthetic and the ultrasonic echo image after treatment can be selected individually or appropriately, any two of them can be selected. The sonic echo image and three ultrasonic echo images are displayed, so the treatment effect can be accurately judged.

Furthermore, in the ultrasonic image diagnosis device of this aspect, it is preferable that the analysis device has an AI (artificial intelligence) mechanism.

AI organization is a field with rapid technological progress. By using a large number of ultrasonic echo images for training, it can accurately and automatically obtain information about the state of the organism below the epidermis. By using the AI mechanism, for example, the distribution or state of sweat glands or skin, the distribution or location or range of skin malignant tumors can be diagnosed.

Furthermore, the treatment device for body odor or hyperhidrosis of the second aspect of the present invention is characterized in that it is equipped with any of the above-mentioned ultrasonic imaging diagnostic devices, sweat suppression devices that destroy sweat glands, and sweat suppression devices that control sweat The control unit is the control unit, and the control unit controls the sweat suppressing device based on the state below the biological skin obtained by the ultrasonic imaging diagnostic device.

According to the treatment device for body odor or hyperhidrosis of this aspect, since the distribution state of sweat glands, the position and depth of sweat glands can be accurately obtained by the ultrasonic imaging diagnostic device, the electrode needle in the sweat suppressing device can be accurately controlled The protruding position, protruding length and power sequence can improve the treatment effect of body odor or hyperhidrosis. With the diagnosis of the above-mentioned ultrasonic imaging diagnostic device, especially the combination of the above-mentioned diagnosis using the AI mechanism, after automatically setting the distribution range of sweat glands required for treatment, the setting and control of the treatment device can be reliably performed.

In the treatment device for body odor or hyperhidrosis of this aspect, it is preferable that the sweat suppressing device has an electrode needle with adjustable protrusion length, and the control unit controls the protrusion length of the electrode needle in multiple stages, and controls the treatment at each stage The above-mentioned electrode needle is energized.

According to this aspect of the treatment device for body odor or hyperhidrosis, sweat glands can be destroyed substantially completely, and the treatment effect of body odor or hyperhidrosis can be improved. In addition, since the length of the electrode needle protruding from the cooling part, for example, apocrine glands or exocrine glands mostly exist in the range of 0.5 to 3.5 mm subcutaneously, it is only necessary to repeat the insertion to the most superficial position where sweat glands are confirmed, and then energize, and then insert 0.5 mm and Power on, then insert 0.5 mm and power on. In addition, the reverse operation can be performed after inserting to the deepest position where sweat glands are first confirmed.

In the treatment device for body odor or hyperhidrosis of this aspect, it is preferable that the sweat suppressing device is provided with the electrode needle and a cooling part formed with a through hole through which the electrode needle can be inserted, and the cooling part is in close contact with On the skin surface of the living body, the electrode needle is protruded from the cooling part and energized to heat the tip of the electrode needle, thereby destroying the sweat glands on the tip side of the electrode needle, and the control part can control the electrode needle of the sweat suppressing device At least one of the position on the surface of the living body's skin, the depth of protrusion from the cooling part, the timing of energizing the electrode needle, the period of energizing the electrode needle, or the strength of energizing the electrode. [Effects of Invention]

As described above, according to the ultrasonic imaging diagnostic device of the present invention, the cross-sectional echo image generating device can obtain a cross-sectional echo image that shows the subcutaneous state well, and the subcutaneous state can be correctly identified by the analysis device to obtain the distribution of sweat glands Information related to the status, location and depth of sweat glands or the location, spreading status and depth of skin malignant tumors, so that the range required to treat body odor or hyperhidrosis or skin malignant tumors can be accurately identified. Furthermore, according to the treatment device for body odor or hyperhidrosis of the present invention, since the distribution state of sweat glands, the position and depth of sweat glands can be accurately obtained by the ultrasonic imaging diagnostic device, the electrodes in the sweat suppressing device can be accurately controlled The protruding position, protruding length and power sequence of the needle can improve the treatment effect of body odor or hyperhidrosis.

Hereinafter, the ultrasonic imaging diagnostic device and the treatment device for body odor or hyperhidrosis of the embodiment of the present invention will be described with reference to the drawings. However, the embodiments shown below are examples of ultrasonic imaging diagnostic devices and treatment devices for body odor or hyperhidrosis for embodying the technical ideas of the present invention, and the present invention is not intended to be specific to them. The present invention can be equally applied to other embodiments included in the scope of the patent application.

[Ultrasonic imaging diagnostic device] First, the outline of the ultrasonic imaging diagnostic apparatus 10 used in the present invention will be described using FIG. 1. The ultrasonic image diagnosis device 10 itself is a known one, as shown in FIG. 1, it includes an ultrasonic probe (probe) 11, an input/output (I/O) unit 12, an echo image generation unit 13, an analysis unit 14, and Display unit 15. Among them, the signal processing unit 16 is formed by the I/O 12, the echo image generating unit 13, and the analyzing unit 14. As the display unit 15, a general liquid crystal display device or an organic EL (Electro Luminescence) display device can be used.

The I/O unit 12 supplies the ultrasonic drive signal of a specific frequency to the ultrasonic probe 11, and receives the echo signal received by the ultrasonic probe 11 and supplies it to the echo image generating unit 13. In the echo image generating unit 13, a signal corresponding to the cross-sectional echo image is generated based on the echo signal, and the cross-sectional echo image is displayed on the display unit 15 based on the signal corresponding to the cross-sectional echo image. In addition, the signal corresponding to the cross-sectional echo image generated in the echo image generating unit 13 is also supplied to the analyzing unit 14. In the analyzing unit 14, for example, AI (Artificial Intelligence) is used to identify sweat glands and generate the distribution of sweat glands. The signals related to the state, the position and depth of the sweat glands are memorized in advance and supplied to the echo image generating unit 13 to be appropriately displayed on the display unit 15. In addition, the echo image generating unit 13 corresponds to the cross-sectional echo image generating device in the present invention, and the analyzing unit 14 corresponds to the analyzing device in the present invention.

The ultrasonic probe 11 uses a marketer. Here, a so-called hockey-type ultra-high frequency linear probe is used. The contact surface 11a on the front end side of the ultrasonic probe 11 is arranged in a row, for example, 126 The linear probe of the above ultrasonic element, but the illustration of each is omitted. As long as the linear probe does not use an ultrasonic lens, the ultrasonic waves are incident perpendicularly to the skin, so the ultrasonic waves will not spread, and a narrow range of cross-sectional echo images can be obtained with good image quality.

In addition, if the frequency of the ultrasonic wave is increased, the ultrasonic wave will be absorbed near the skin, but since most of the sweat glands actually exist in the shallow range of 0.5 mm to 3.5 mm under the skin, the cross section near the skin surface can be obtained with high sensitivity Echo image. If the number of ultrasonic components is further increased, the analysis performance can be improved, and high-definition cross-sectional echo images can be obtained.

The dimensions of the contact surface 11a of the ultrasonic probe 11 used in the ultrasonic imaging diagnostic apparatus 10 of the embodiment are shown in Figure 2. The width is 3 to 5 mm, and the length is about 3 cm. It is arranged in the longitudinal direction. There are more than 126, depending on the situation, more than 256 ultrasonic components. Specifically, the number of ultrasonic elements may be, for example, about 200, or, for example, 400 to 600 or more. In addition, the direction corresponding to the long side direction of the contact surface 11a in FIG. 2 is the long axis direction, and the direction corresponding to the width direction is the short axis direction.

The ultrasonic probe 11 includes a substantially rectangular contact surface 11a with a long side and a short side. The scanning direction of the ultrasonic probe is divided into a scanning direction along the long side direction and a direction along the short side direction. Find out the distribution of sweat glands accurately and effectively. When determining the treatment range, first, scan along the long side to grasp the distribution range of sweat glands. That is, in scanning along the long side, although the scannable width (length of the short side) is narrow, the display range (length of the long side) along the scanning direction is wide, so sweat glands can be clearly identified. After knowing the distribution range of sweat glands, then scanning along the short side direction is used to effectively grasp the wide range of sweat gland distribution by scanning in a state where the scannable width (length of the long side) is relatively wide. Moreover, the cross-sectional echo image obtained in this way is of high analytical power and high quality compared with the previous ones. Therefore, the analysis unit 14 can more accurately identify the sweat glands and obtain the correlation between the distribution state of the sweat glands, the position and depth of the sweat glands News.

In addition, according to the ultrasonic imaging diagnostic apparatus 10 of the embodiment, since the position and depth of the sweat glands can be accurately obtained by the analysis unit 14, the ultrasonic probe 11 is placed at that position in the direction of the long axis of the contact surface as A 3D (Dimensional) ultrasonic echo image can be obtained by rotating the center to perform a rotating scan, or by performing a scan along the short side of the ultrasonic probe 11. Moreover, since the distribution range of sweat glands can be grasped by the scanning direction along the long-side direction and the direction along the short-side direction, that is, because the location of sweat glands is not known in advance, it reduces the acquisition of useless 3D data and reduces The processing burden of the profile echo image generating unit 13 and the analyzing unit 14.

In addition, in the treatment of body odor or hyperhidrosis, since the injection of anesthetic is performed before the treatment, the image displayed on the display unit 15 is preferably selected and displayed appropriately before treatment (before injection of anesthetic), after injection of anesthetic, and after treatment Of 3 kinds of images. In this way, the treatment effect can be recognized more accurately. The image after the injection of anesthetic agent tends to be easier to grasp the position of the sweat glands by the ultrasonic probe 11 than the image before the injection of anesthetic agent.

[Sweat suppression device] Next, referring to FIG. 3, the sweat suppressing device 20 used in combination with the ultrasonic imaging diagnostic device 10 of the embodiment will be described. In addition, the combination of the ultrasonic imaging diagnostic device 10 and the sweating suppression device 20 corresponds to the treatment device 50 for body odor or hyperhidrosis of the present invention. However, as the sweat suppressing device 20, not only the one shown in FIG. 3, but other conventional structures may also be used.

The sweat suppression device 20 includes an electrode needle 21, a cooling member 22, a support body 23, and a driving device 24 as main components. The electrode needle 21 includes a conductive metal material such as stainless steel, and the tip portion 21a is tapered in a pierceable manner. The portion of the electrode needle 21 other than the front end 21a is covered by an insulating film 21b containing an electrically insulating material. A plurality of electrode needles 21 are arranged in a matrix, and they are fixed to a bracket 25 having a rectangular plate shape.

The electrode needles 21 are preferably arranged, for example, about 20 to 30 needles (or more), and the interval between adjacent electrode needles 21 is preferably set to, for example, 0.5 to 3 mm (more preferably 1 to 3 mm). The thickness of each electrode needle 21 is preferably, for example, about 0.1 to 0.3 mm. The arrangement shape of the plurality of needle electrode needles 21 may be various shapes such as a ring shape or a polygonal shape other than the matrix shape. The bracket 25 includes a plastic material, etc., and a recess 25a is formed in the center. An elastically deformable engagement protrusion 25b is provided on the inner peripheral surface of the recess 25a. The front end 21a of the electrode needle 21 is formed as a blunt needle that penetrates the skin and subcutaneous tissue, but does not penetrate the subcutaneous tissue and the membranous tissue between the muscles, so that only the deep area where sweat glands may exist can be safely punctured.

The cooling member 22 includes a Peltier element 26, a cooling plate 27, and a heat dissipation block 28. The Peltier element 26 is a conventional structure in which p-type semiconductors and n-type semiconductors are thermally arranged and arranged. A cooling plate 27 is provided on the heat absorption side of the Peltier element 26, and a heat sink 28 is provided on the heat-generating side of the Peltier element 26 . The Peltier elements 26 are arranged in a matrix with a plurality of suitable sizes. The cooling plate 27 and the heat dissipation block 28 are formed with a plurality of openings 27a, 28a in the gap between the plurality of Peltier elements 26, and the openings 27a, 28a facing each other form a plurality of through holes 29 penetrating the front and back of the cooling member 22 . The cooling plate 27 has a flat cooling portion 27b on the front side, and the cooling portion 27b can be closely attached to the skin of the human body.

The cooling portion 27b is provided with an abutment detection sensor 30 that detects the abutment state of the punctured part such as human skin and the cooling portion 27b on the front side avoiding the opening 27a at the approximate center. The contact detection sensor 30 includes a pressure sensor with a relatively thin thickness (for example, about 0.1 mm), and outputs a contact signal or a non-contact signal with the punctured part.

The support body 23 is provided with: a rectangular housing portion 31 in a plan view, which is open below in FIG. 3A; and a cylindrical portion 32 which is connected to the center of the top plate of the housing portion 31; and is connected to the housing portion Electrode needle 21 is held inside 31. The housing portion 31 is formed with a guide groove 31a near the opening of a pair of side walls facing each other. The cooling member 22 is supported by the support body 23 in such a way that the heat dissipation block 28 can slide along the guide groove 31a. In the closed position covering the opening of the housing portion 31, the front end 21a of each electrode needle 21 is opposed to the through hole 29, Instead, the electrode needle 21 can be inserted into the through hole 29. A terminal part (not shown) is provided in the guide groove 31a, and when the cooling member 22 is located in the said closed position, the Peltier element 26 can be energized.

The driving device 24 includes a driving motor 33 that includes a servo motor and the like; an encoder 34 that detects the number of rotations of the driving motor 33; and a slide bar 36 that advances and retreats by the rotation of the driving motor 33. A shaft 35 is connected to the rotating shaft 33a of the drive motor 33, and a threaded portion 35a is formed on the outer peripheral surface of the shaft 35. The slide bar 36 is formed in a hollow cylindrical shape, and is slidably housed in the cylindrical portion 32 of the support body 23. On the inner peripheral surface of the sliding rod 36, a nut 36a screwed to the threaded portion 35a of the shaft 35 is fixed. On the other hand, a protrusion 36b is provided on the outer peripheral surface of the slide bar 36, and the protrusion 36b is engaged with the groove portion 32a formed on the inner peripheral surface of the cylindrical portion 32, thereby preventing the slide bar 36 from rotating. With the above configuration of the driving device 24, the sliding rod 36 can be moved in and out of the lower part of FIG. 3B by the rotation of the driving motor 33, and the in and out amount of the sliding rod 36 can be controlled based on the detection of the encoder 34.

An engagement recess 36c is formed on the outer peripheral surface of the front end side of the slide bar 36 (the lower end side in FIG. 3A). The slide bar 36 is fitted into the recess 25a of the bracket 25 and the engagement recess 36c is engaged with the engagement protrusion 25b, Thereby, the bracket 25 can be detachably fixed to the sliding rod 36. In this way, the support 25 can be pressed by the driving device 24, and by the advancement of the slide bar 36, as shown by the dashed line in FIG. 3A, the front end 21a of the electrode needle 21 can come and go from the cooling part 27b. The protrusion amount of the electrode needle 21 from the lowermost surface of the cooling part 27b can be set to, for example, about 0.1-10 mm.

In addition, when a mounting bracket 25 is provided at the front end of the slide bar 36, a terminal (not shown) for supplying power to each electrode needle 21 is provided, and each electrode needle 21 is electrically connected to an external high-frequency oscillator (not shown) Icon). When the electrode needle 21 is pierced into the human body, a high-frequency current can be applied to a surface electrode (not shown) additionally disposed on the surface of the human body, thereby heating the biological tissue near the electrode needle 21. When a plurality of electrode needles 21 are provided, it may be configured to apply a high-frequency current between two adjacent electrode needles 21.

The energization of the electrode needle 21, the cooling member 22, and the driving device 24 can be performed manually by the switch operation of the operating portion 40 provided in the cylindrical portion 32 of the support body 23. In addition, the sweat suppression device 20 of this embodiment can be connected to a personal computer or other control device 45 that can be installed externally, and the detection signal of the contact state (contact or non-contact) of the contact detection sensor 30 is input to The control device 45 can also control the energization of the electrode needle 21, the cooling member 22 and the driving device 24 through the control device 45.

In addition, the ultrasonic image diagnosis apparatus 10 has an output unit (not shown) that outputs an ultrasonic echo image and analysis results, and information from the output unit is input to the control device 45. Since the information of the diagnosis result from the ultrasonic imaging diagnostic device 10 is input to the control device 45, it is possible to control the sweat suppressing device 20 by appropriately grasping the treatment range (range of the distribution or depth of sweat glands) by using the information. The control device 45 can control the position of the electrode needle of the sweat suppressing device on the surface of the biological body's epidermis, the depth of protrusion from the cooling part, the timing of electrifying the electrode needle, the period of electrifying the electrode needle, and the intensity of electrifying the electrode based on the information. . The diagnosis result information from the ultrasonic imaging diagnosis device 10 may also include control parameters used in the control device 45. As a control parameter, in addition to the information about the distribution of sweat glands, the location of sweat glands, the depth range of sweat glands, and the density of sweat glands, it can also contain the information required for treatment of each part, such as the electrode needle of the sweat suppression device in the living body The position of the surface of the epidermis and the depth of the protrusion from the cooling part correspond to the timing of electrifying the electrode needle, the period of electrifying the electrode needle, and the intensity of electrifying the electrode. In particular, when the ultrasonic imaging diagnostic device 10 has an AI mechanism, more detailed information required for treatment can be obtained. In addition, since the control device 45 memorizes the patient's past treatment history information, it can refer to the past treatment history to control the sweat suppression device 20. Furthermore, it is also possible to share all or a part of the signal processing unit 16 of the ultrasonic image diagnosis apparatus 10 and all or a part of the control device 45 to be realized as a control mechanism such as a personal computer. In addition, AI can also be used for calculations in the control device 45. In this case, a large amount of treatment history information or a large amount of information from the ultrasound imaging diagnostic device 10 can be used to determine the treatment range of this treatment or each treatment site The control parameters of the sweat suppression device 20.

Furthermore, information about the distribution of sweat glands, the position and depth of sweat glands obtained in the analysis unit 14 of the above-mentioned ultrasonic imaging diagnostic apparatus 10 (refer to FIG. 1) can be obtained, and the protruding amount of the electrode needle 21 is displayed on the control The display part of the device 45 automatically controls the protrusion amount and energization of the electrode needle 21. In addition, the control device 45 may also be built into the operating part 40, and the control device 45 corresponds to the control part in the body odor or hyperhidrosis treatment device of the present invention. When the information related to the distribution state of sweat glands, the position and depth of sweat glands, and the depth of sweat glands obtained by the analysis unit 14 of the ultrasonic imaging diagnostic device 10 are displayed on the display portion of the control device 45, the ultrasonic imaging diagnostic device 10 and the control device 45 , Can use LAN (Local Area Network: local area network), IEEE1394 serial bus, USB (Universal Serial Bus: universal serial bus), wired, infrared communication, Bluetooth (registered trademark), IEEE802.11, etc. Wireless, etc., can also be entered manually.

Next, the method of using the sweat suppressing device 20 having the above-mentioned configuration will be described. First, the holder 25 with the electrode needle 21 is mounted on the slide bar 36 of the driving device 24. In a state where the cooling member 22 is retracted from the support body 23 to open the opening of the housing portion 31, the bracket 25 engages the engagement protrusion 25 b and the engagement recess 36 c to fix the bracket 25 to the slide bar 36. Next, the cooling portion 27b of the cooling member 22 is brought into close contact with the epidermal surface of the punctured site including sweat glands. In addition, when the ultrasonic imaging diagnostic device 10 is used to confirm the distribution of sweat glands, if the punctured part of the sweat suppressing device 20 is marked on the skin surface, the heating can be suppressed to the range where the sweat glands to be treated does not exist, so it is preferable .

When the cooling portion 27 b is in close contact with the surface of the skin, the contact detection sensor 30 inputs a contact signal to the control device 45. In this state, the control device 45 rotates the drive motor 33 of the drive device 24 by the operation of the operating part 40. When the sliding rod 36 engages the protrusion 36b with the groove portion 34a and cannot rotate, the nut 36a is screwed with the shaft 35. Therefore, according to the rotation amount of the drive motor 33, each electrode needle 21 is driven from the cooling portion 27b. Gradually stand out.

Generally speaking, apocrine glands or exocrine glands actually exist almost in the range of 0.5 mm to 3.5 mm subcutaneously. The ultrasonic imaging diagnostic device 10 is used to determine the range of sweat glands, and it can be seen that the sweat glands are present in the range of, for example, 1.5 mm to 3.0 mm. Repeatedly set the protrusion depth L of the electrode needle 21 to 1.5 mm and energize, and then extend it by 0.5 mm Then, extend the protrusion by 0.5 mm and energize the operation, and repeat the operation until the protrusion of the electrode core 21 is 3.0 mm, and finally the needle is pulled out. In addition, it is also possible to drive the protruding amount of the electrode needle 21 from the deeper to the shallower.

Thereby, uniform heating can be performed along the depth direction of the punctured part, and all sweat glands in the area can be destroyed efficiently and surely. The thermal energy supplied from the electrode needle 21 can be changed according to the depth interval, and can also be configured such that the greater the depth interval, the greater the thermal energy supplied. The supply of heat energy can use various waves such as high-frequency waves, radio waves, and microwaves.

The surface of the epidermis cools the periphery of the puncture site by the close contact of the cooling portion 27b, so that scalds can be prevented, and pain relief during puncture and heat supply can be performed well. In addition, if a part of the anesthetic is injected into the subcutaneous where the cooling part 27b is in close contact, an analgesic effect can be obtained. As will be described later, the echo image of the sweat gland obtained by the ultrasonic probe 11 of the ultrasonic imaging diagnostic apparatus 10 is good Identify sweat glands.

[Subcutaneous electron microscope photo image] First, in order to illustrate the structure of skin tissue, Figure 4 shows an electron micrograph image of the skin tissue sample obtained by sampling and staining the skin tissue. The subcutaneous tissue is the dermis with a thickness of about 0.5 mm below the epidermis, and there are apocrine and exocrine glands below it. The depth of existence of these apocrine glands and exocrine glands is about 0.5 mm～3.5 mm. In addition, the lower part of the apocrine and exocrine glands is the fat layer. In addition, it is known that the thickness of the epidermis varies greatly depending on the location, with thinner ears or underarms, and thicker palms or soles.

[Observation example] In the following, in order to confirm the effect of the treatment device 50 for body odor or hyperhidrosis of the present invention, the above-mentioned ultrasonic imaging diagnostic device 10 was used for each part of 10 patients. (1) Before treatment (2) After injecting the anesthetic under the skin, and (3) After treatment with the above sweat suppressing device 20 In addition to obtaining ultrasonic profile echo images at 3 time points, 3D ultrasonic echo images in any one of the states (1) to (3) above are also properly obtained. The results are shown in Figures 5-14.

However, the location of each ultrasound profile echo image and 3D ultrasound echo image is that the ultrasound probe is taken out after the measurement before the end of treatment by one ultrasound probe, and after the injection of anesthetic, The ultrasonic probe was again abutted to the place considered to be the same position for measurement, so a slight shift occurred. Therefore, microscopically, the image of the same measurement site may not be displayed. It is the same after injection of anesthetic and after treatment.

The scanning range of the ultrasonic probe 11 is to first determine the reference point. From the reference point, for example, from the hand to the armpit, the ultrasonic probe 11 is scanned about 50 mm along the longitudinal direction, and then the peripheral direction ultrasonic probe The needle 11 scans about 30 mm along the longitudinal direction to find the distribution of sweat glands. Subsequently, at the position where the sweat glands are confirmed, the ultrasonic probe 11 scans in two directions along the short side to obtain the cross-sectional echo images of the sweat glands.

In addition, the treatment of the sweat suppressing device 20 is based on the depth range of the sweat glands obtained by the ultrasonic imaging diagnostic device 10 in advance. The protruding depth L of the electrode needle 21 is repeatedly set to the shallowest depth of existence and energized, and then extended by 0.5 The operation of extending the protrusion amount of 0.5 mm and electrifying is carried out until the protrusion amount of the electrode needle 21 reaches the deepest existence depth.

In observation examples 1-7, Aplioi-800 (trade name) manufactured by CANON MEDCIAL was used as the ultrasonic imaging diagnostic device, and the high-frequency linear probe PLI-20020BT (trade name) was also used as the ultrasonic probe . In addition, the number of ultrasonic elements of the ultrasonic probe is about 200, and 22 MHz ultrasonic waves are used for measurement. Moreover, the distribution of sweat glands is obtained by scanning the direction along the long side of the ultrasonic probe, and then the echo image of the section of sweat glands is obtained by scanning along the direction of the short side, thereby specifying the range The treatment range of sweat glands. The 3D ultrasonic echo image is obtained by rotating the ultrasonic probe around the long axis direction of the contact surface or scanning along the short axis direction. In addition, in the 3-dimensional ultrasonic echo image, the echo image of the ultrasonic profile on the left side is used to confirm whether the blood vessel is injured. As a sweat suppressing device, the View Hot III (trade name) of the induction heating method of the electrode needle is used. In addition, in Observation Examples 8 to 10, the number of ultrasonic elements used as ultrasonic probes is about 400 to 600, and the ultrasonic probes of 33 MHz are used for users.

In the diagrams of the following observation examples, the areas marked by circles, ellipses, and squares are the areas where sweat glands exist. In this embodiment, the analysis unit 14 of the ultrasonic imaging diagnostic device 10 analyzes the distribution of the sweat glands, and grasps the distribution of the sweat glands, the location of the sweat glands, the depth range of the sweat glands, and the density of the sweat glands.

[Observation example 1] Figure 5 is an observation example of the underarm of a 12-year-old female. Figure 5A, Figure 5B, Figure 5C, and Figure 5D are respectively the ultrasound cross-sectional echo images of before treatment, after injecting anesthetic under the skin, after treatment, and after treatment at other locations , Figure 5E, Figure 5F, Figure 5G are 3D ultrasound echo images before treatment, after injecting anesthetic under the skin, and after treatment, respectively.

According to the ultrasound cross-sectional echo images shown in Figures 5A to 5D, apocrine glands and exocrine glands (hereinafter, sometimes referred to as "sweat glands") can be well confirmed before treatment (Figure 5A) and after injection of anesthetic (Figure 5B) ), but after treatment (Figure 5C and Figure 5D), it was confirmed that the sweat glands had disappeared substantially. This situation can also be confirmed from Figures 5E to 5G of the 3D ultrasonic echo images. Also, according to the ultrasonic echo images shown on the left side of each of FIGS. 5E to 5G, especially in FIG. 5G, there is no area of blood leakage, so it was confirmed that no blood vessel damage was caused during the treatment.

[Observation example 2] Fig. 6 is an observation example of the underarm of a 19-year-old female. Fig. 6A, Fig. 6B, and Fig. 6C are respectively before treatment, after injecting anesthetic under the skin, and after treatment, Fig. 6D, Fig. 6E, Fig. 5F The 3D ultrasound echo images before treatment, before treatment, and after treatment observed from a different direction from Figure 6D.

According to the ultrasonic cross-sectional echo images shown in Figure 6A to Figure 6C, sweat glands can be well confirmed before treatment (Figure 6A) and after injection of anesthetic (Figure 6B), but after treatment (Figure 6C), sweat glands are confirmed to be substantial disappear. This can also be confirmed from Fig. 6D to Fig. 6F of the 3D ultrasonic echo image.

[Observation example 3] Fig. 7 is an observation example of the armpit of a 55-year-old woman. Fig. 7A, Fig. 7B, and Fig. 7C are the ultrasound cross-sectional echo images before treatment, after injecting anesthetic under the skin, and after treatment, respectively. Fig. 7D and Fig. 7E are treatment respectively 3D ultrasound echo images before and after treatment.

According to the ultrasonic cross-sectional echo images shown in Figures 7A to 7C, sweat glands can be well confirmed before treatment (Figure 7A), and the outline of sweat glands can be confirmed after injection of anesthetic (Figure 7B). Later (Figure 7C), it was confirmed that the sweat glands had disappeared substantially. This situation can also be confirmed from Fig. 7D and Fig. 7E of 3D ultrasonic echo images. In addition, according to the ultrasonic echo images shown on the left side of each of Fig. 7D and Fig. 7E, especially in Fig. 7E, since there is no area of blood leakage, it is confirmed that there is no damage to the blood vessel during the treatment.

[Observation example 4] Figure 8 is an example of observation of the lateral surface of the right thigh of a 53-year-old male. Figures 8A, 8B, and 8C are the echo images of the ultrasound profile before treatment, after injecting anesthetic under the skin, and after treatment, respectively. Figures 8D and 8E respectively It is the 3D ultrasound echo images before and after treatment.

According to the ultrasound cross-sectional echo images shown in Figures 8A to 8C, sweat glands can be well confirmed before treatment (Figure 8A), and after the injection of anesthetic (Figure 8B) the outline of sweat glands can be confirmed although it is not clear. Later (Figure 8C) it was confirmed that the sweat glands had disappeared substantially. This can also be confirmed from Figure 8D and Figure 8E of the 3D ultrasonic echo image.

[Observation example 5] Figure 9 is an observation example of the dorsal side of an 18-year-old male. Figures 9A, 9B, and 9C are the echo images of the ultrasound profile before treatment, after the injection of anesthetic under the skin, and after treatment, respectively. Figures 9D and 9E are respectively before treatment , 3D ultrasound echo images after treatment.

According to the ultrasound cross-sectional echo images shown in Figures 9A-9C, sweat glands can be well confirmed before treatment (Figure 9A), and the outline of sweat glands can be confirmed after injection of anesthetic (Figure 9B). Later (Figure 9C), it was confirmed that the sweat glands had disappeared substantially. This situation can also be confirmed from Figure 9D and Figure 9E of the 3D ultrasonic echo image.

[Observation example 6] Fig. 10 is an observation example of the armpit of a 55-year-old woman. Fig. 10A and Fig. 10B are 3D echo echo images before and after treatment, respectively.

According to the 3D ultrasonic echo images shown in Figs. 10A and 10B, the sweat glands can be confirmed well before treatment (Fig. 10A), and after treatment (Fig. 10B), it is confirmed that the sweat glands have disappeared substantially. This situation can also be confirmed from Figure 9D and Figure 9E of the 3D ultrasonic echo image. In addition, according to the ultrasonic echo images shown on the left side of each of FIGS. 10A and 10B, especially in FIG. 10B, since there is no area of blood leakage, it was confirmed that no blood vessel was damaged during the treatment.

[Observation example 7] Figure 11 is an observation example of the armpit of a 38-year-old female. Figures 11A and 11B are 3D echo echo images before and after treatment, respectively.

According to the 3D ultrasonic echo images shown in Figs. 11A and 11B, the sweat glands were well confirmed before the treatment (Fig. 11A), and after the treatment (Fig. 11B), the sweat glands were confirmed to disappear substantially.

[Observation example 8] Fig. 12 is an observation example of the underarm of a 13-year-old woman who complained of recurrence after using the sweat suppressing device of the embodiment. Fig. 12A and Fig. 12B are ultrasound cross-sectional echo images and 3D ultrasound cross-sectional echo images of non-recurring parts, respectively. Fig. 12C and Fig. 12D are the echo images of the ultrasound profile and the 3D echo images of the ultrasound profile of the recurrence site.

No recurrence was seen in the echo image of the ultrasound profile shown in FIG. 12A and the 3D echo profile of the ultrasound profile shown in FIG. 12B. However, in the ultrasonic cross-sectional echo image shown in FIG. 12C and the 3D ultrasonic cross-sectional echo image shown in FIG. 12D, sweat gland images can be seen in the area shown by the box, and it is judged as a relapse.

[Observation example 9] Figure 13 is an example of the observation of preoperative exocrine glands in a 14-year-old female with palm hyperhidrosis. Figure 13A is an ultrasound profile echo image, and Figure 13B is also a 3D ultrasound profile echo image.

According to Fig. 13A and Fig. 13B, it is confirmed that after using the ultrasonic probe of the embodiment, sweat glands in thicker parts of the epidermal layer of the palm can be clearly observed.

[Observation example 10] Fig. 14 is an observation example of the apocrine glands under the armpit of a 14-year-old female with a 33 MHz drive probe. Fig. 14A, Fig. 14B and Fig. 14C are the ultrasound cross-sectional echo images before treatment and after local anesthesia, respectively. Fig. 14D The 3D ultrasound profile echo images before treatment, Figure 14E is the ultrasound profile echo images after treatment, and Figure 14F is the 3D ultrasound profile echo images after the treatment.

According to Fig. 14A to Fig. 14F, when the ultrasonic probe used in the embodiment is driven at a frequency of up to 33 MHz, it can be seen from the comparison with Fig. 5A to Fig. 5G which is driven at 22 MHz. It can be seen that before and after treatment Both can get a clear image. In particular, when comparing FIGS. 14A to 14D with FIGS. 14E and 14F, the apocrine gland image and its disappearance state can be understood well.

In addition, Figure 15 shows the echo images of the pre-operative animation of the above-mentioned 14-year-old woman’s armpit using a 33 MHz drive probe, and Figure 16 shows the echo images of the animation of the ultrasound cross-section after local anesthesia. Figures 15 and 16 show the images when each ultrasound probe is scanned from a position where the apocrine gland does not exist. According to the animation, the apocrine gland in the treatment site of body odor can also be clearly identified.

In the ultrasonic image diagnosis device of the above-mentioned embodiment, in addition to the cross-sectional image in a section of the static image, the ultrasonic cross-sectional echo image including the 3D image or the dynamic image can be displayed. In the ultrasonic image diagnosis device of the above embodiment, an AI mechanism is incorporated, such as a neural network or a convolutional neural network that has advantages in image recognition, and the ultrasonic echo image is used as teacher data for training, thereby , It can quickly and accurately obtain information about the distribution state of sweat glands, the location and depth of sweat glands, the location of skin malignant tumors, the spreading state, depth, and infiltration information from the subject’s ultrasound echo images. In this case, in addition to the cross-sectional image in one of the static images, ultrasonic cross-sectional echo images including 3D images or dynamic images can be used. In particular, by using the ultrasonic profile echo images of dynamic images, it is possible to analyze malignant tumors of sweat glands or skin with higher accuracy.

In addition, in the observation example using the ultrasonic imaging diagnostic device of the above-mentioned embodiment, an example of ultrasonic cross-sectional images showing exocrine glands and apocrine glands has been shown, but for example, the ultrasonic imaging diagnostic device can be applied to skin cancer Under the circumstances, a good diagnosis effect of skin cancer is obtained. That is, according to the ultrasonic image diagnosis device of the above-mentioned embodiment, since the cross-sectional echo image generating device can obtain a cross-sectional echo image that shows the subcutaneous state well, the location, spreading state, and depth of skin cancer can be clearly displayed. And can help improve the treatment effect of skin cancer. For example, if the 33 Mhz ultrasound probe described in observation examples 8 to 10 is used, the diagnosis of skin cancer within 1 cm from the surface of the skin can be performed, which is particularly excellent. Also, similarly, it is possible to diagnose malignant tumors of the skin including skin cancer or malignant melanoma.

10: Ultrasonic imaging diagnostic device 11: Ultrasonic probe (probe) 11a: contact surface 12: Input and output (I/O) section 13: Echo image generator 14: Analysis Department 15: Display 16: Signal Processing Department 20: Sweat suppression device 21: Electrode needle 21a: Front end 21b: insulating film 22: Cooling components 23: Support 24: Drive 25: bracket 25a: recess 25b: Snap protrusion 26: Peltier element 27: Cooling plate 27a: opening 27b: Cooling part 28: heat sink 28a: opening 29: Through hole 30: Contact detection sensor 31: Shell 31a: Guide groove 32: Cylinder 32a: Groove 33: drive motor 33a: Rotation axis 34: encoder 35: axis 35a: Threaded part 36: Slider 36a: Nut 36b: protrusion 36c: engagement recess 40: Operation Department 45: control device 50: Treatment device for body odor or hyperhidrosis L: prominent depth

Fig. 1 is a schematic diagram of the ultrasonic imaging diagnostic device of the present invention. Fig. 2 is an explanatory diagram of the size and the direction of the long axis and the short axis of the ultrasonic probe. Fig. 3A is a side view of the sweat suppressing device used in the embodiment of the present invention, and Fig. 3B is a partial cross-sectional view taken along the line IIIA-IIIA of Fig. 3A. Figure 4 is an electron micrograph of the stained skin tissue. Figures 5A to 5F are observation examples of the underarms of a 12-year-old female. Figures 6A to 6E are observation examples of the underarm of a 19-year-old female. Figures 7A-7E are observation examples of the armpits of a 55-year-old female. Figures 8A to 8E are observation examples of the outer surface of the right thigh of a 53-year-old male. Figures 9A-9E are observation examples of the dorsal side of an 18-year-old male. Figures 10A and 10B are observation examples of the armpit of a 55-year-old female. Figures 11A and 11B are observation examples of the armpit of a 38-year-old female. Figures 12A to 12D are observation examples of the underarms of a 13-year-old woman who complained of recurrence after surgery using the sweat suppression device of the embodiment. Figures 13A and 13B are preoperative observation examples of a 14-year-old female with palm hyperhidrosis. Figures 14A to 14F are observation examples of a 14-year-old female underarm using a 33 MHz drive probe. Figures 15A-15D are captured images of the preoperative animation of a 14-year-old female underarm using a 33 MHz driven probe. Figures 16A-15D are captured images of a 14-year-old female underarm after local anesthesia using a 33 MHz driven probe.

10: Ultrasonic imaging diagnostic device

11: Ultrasonic probe (probe)

11a: contact surface

12: Input and output (I/O) section

13: Echo image generator

14: Analysis Department

15: Display

16: Signal Processing Department

Claims (10)

An ultrasonic image diagnosis device, which is characterized by having: Ultrasonic probe A cross-sectional echo image generating device, which generates cross-sectional echo images by scanning signals from the above-mentioned ultrasonic probe; and An analysis device, which analyzes the cross-sectional echo image by the above-mentioned cross-sectional echo image generating device to identify the subcutaneous state; and The above-mentioned ultrasonic probe includes a substantially rectangular contact surface with a long side and a short side, and can scan at least the long side direction and the short side direction; The cross-sectional echo image generating device displays cross-sectional echo images based on the scanning signals obtained by scanning the long-side direction and the short-side direction of the ultrasonic probe on the surface of the biological body's epidermis; The analysis device obtains and displays information related to the state below the epidermis of the organism based on the cross-sectional echo image. Such as the ultrasonic imaging diagnostic device of claim 1, wherein the state below the epidermis of the organism is information related to the distribution state of sweat glands, information related to the location of sweat glands, information related to the depth of sweat glands, and related to the location of malignant tumors of the skin At least one of information, information related to the spread status of skin malignant tumors, depth of skin malignant tumors, or information related to skin malignant tumors infiltration. For example, the ultrasonic imaging diagnostic device of claim 1 or 2, wherein the ultrasonic probe is a linear probe equipped with a row of ultrasonic driving elements, and the driving frequency is 20 MHz or more. Such as the ultrasonic imaging diagnostic device of any one of claims 1 to 3, wherein the analysis device determines the measurement range by scanning the ultrasonic probe along the longitudinal direction, and in the determined measurement range, By scanning the ultrasonic probe along the short-side direction, the state below the skin of the living body can be grasped. The ultrasonic image diagnosis device of any one of claims 1 to 4, wherein the cross-sectional echo image generating device can obtain 3D ultrasonic cross-sectional echo images. The ultrasonic imaging diagnostic device of any one of claims 1 to 5, wherein the cross-sectional echo image generating device selects at least one of cross-sectional echo images before and after injecting anesthetic into the epidermal surface of the living body And to be displayed. For example, the ultrasonic image diagnosis device of any one of claims 1 to 6, wherein the analysis device has an AI (artificial intelligence) mechanism. A treatment device for body odor or hyperhidrosis, characterized in that it is provided with the ultrasonic imaging diagnostic device according to any one of claims 1 to 7, a sweat suppressing device that destroys sweat glands, and a control unit for controlling the sweat suppressing device; and The control unit controls the sweat suppressing device based on the state below the epidermis of the living body obtained by the ultrasonic imaging diagnostic device. The treatment device for body odor or hyperhidrosis of claim 8, wherein the sweat suppressing device has an electrode needle with adjustable protruding length; and The control unit controls the protruding length of the electrode needle in multiple stages, and controls the energization of the electrode needle in each stage. A treatment device for body odor or hyperhidrosis, wherein the sweat suppressing device is provided with the electrode needle, and a cooling part formed with a through hole through which the electrode needle can be inserted, and the cooling part is in close contact with the living body On the skin surface, the electrode needle protrudes from the cooling part and is energized to heat the front end of the electrode needle, thereby destroying the sweat gland on the front end of the electrode needle; and The control unit can control the position of the electrode needle of the sweat suppressing device on the surface of the biological skin, the depth of protruding from the cooling portion, the timing of energizing the electrode needle, the period of energizing the electrode needle, or the electrode energizing At least one of the strengths.

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