TW202039010A - Method and system for decontaminating small enclosures - Google Patents

Abstract

A method, system and apparatus are described for decontaminating small enclosures, semi-enclosed and closed areas of pathogens by using a very dry mist comprising ionized hydrogen peroxide. The system can be controlled manually by the user, or by a remote connection, such as a wireless network connection. The method includes use of a handheld, point-and-spray device that sprays a very dry mist comprising ionized hydrogen peroxide under manual or automated control.

Description

Method and system for purifying small enclosure

This application generally relates to a device and method for purifying products, enclosed spaces and non-enclosed spaces, and more particularly, it relates to the purification of microorganisms in these locations.

Microbial species are widely distributed in our environment. Most microbial species are irrelevant because they do not destroy other organisms. However, other microbial species may infect humans or animals and cause harm to them. For a long time, people have been working to eliminate harmful microbial organisms or make them ineffective. Medicines and medical devices are sterilized and packaged in sterile containers. Medical environments such as operating rooms, wards, and examination rooms are disinfected by various cleaning procedures so that harmful microorganisms cannot be transmitted from one patient to another.

Many available technologies for controlling microbial organisms have limited value in the public health environment of biological warfare and bioterrorism. However, current technologies to address these situations have limited effectiveness in tightly closed environments.

One of the challenges of controlling microbial organisms is the purification of enclosures. In this environment, it is not uncommon for the mist of the purifier to travel several feet in compressed air under normal settings. In a small enclosing body, excessive exposure to spray leads to several undesirable results. For example, one such disadvantage is the saturated surface near the sprayer or on the surface opposite the sprayer. In addition, incorrect fog adjustment may result in wetter and denser fog, which affects the visibility and breathability of the small enclosing body. Therefore, the released mist undesirably increases moisture accumulation and condensation, and its remedy requires increased ventilation time.

There is a need for a new method that is easier to use in small enclosures, has enhanced lethality and simpler mechanical maintenance. This application satisfies this need and further provides related advantages.

One aspect of this application relates to a method of purifying small enclosures, including the following steps: inputting input parameters of small enclosures into a processing unit, wherein the processing unit is programmed to determine the purification based on the input parameters of small enclosures The fluid characteristics of the cleaning fluid in the equipment start the purification cycle of the purification equipment, where the purification cycle includes the following steps: providing a reservoir of the cleaning fluid; setting the determined fluid characteristics of the cleaning fluid; generating a cleaning fluid containing ionized hydrogen peroxide Extremely dry mist, where the generated extremely dry mist is applied to purify the small enclosing body.

In some embodiments, the purification equipment is manually operated. In certain implementation aspects, the purification equipment is handheld.

In some embodiments, the input parameters of the small enclosure include: the size of the small enclosure, the position of the purification equipment relative to the boundary of the small enclosure, and the temperature, pressure and humidity of the small enclosure. In a specific embodiment, the fluid characteristics of the set cleaning fluid include air pressure and fluid flow rate. In other embodiments, the determined fluid characteristics of the cleaning fluid are set by controlling the air valve. In some embodiments, the processing unit is programmed to control the potentiometer, thereby controlling the air valve. In various implementation aspects, the fluid characteristics of the determined cleaning fluid are adjusted by the size and shape of the tube at the outlet of the cleaning fluid outside the purification device.

In a specific embodiment, the fluid characteristics of the cleaning fluid are set by reducing the air pressure and the fluid flow rate to below a predetermined standard air pressure and a predetermined standard fluid flow rate, respectively.

In other embodiments, the input parameters of the target area are input to the processing unit, and the processing unit is further programmed to determine the fluid characteristics of the cleaning fluid in the purification device based on the input parameters of the target area. You can manually enter the input parameters of the small enclosure. The input parameters of the small enclosure are measured by a plurality of sensors that communicate with the processing unit through a network.

In a specific implementation aspect, the processing unit and the purification device are in wireless communication.

Another aspect of this application is a system for purifying small enclosures, including purification equipment and a computer processor, wherein the computer processor communicates with the purification equipment through a network, and the input parameters of the small enclosures are input to the computer processor, and the computer The processor is programmed to determine the fluid characteristics of the cleaning fluid in the purification equipment based on the input parameters of the small enclosure. The computer processor is further programmed to start the purification cycle of the purification equipment. The purification cycle includes the following steps: Reservoir; set the fluid characteristics of the determined clean fluid; generate a very dry clean fluid mist, wherein the generated very dry mist is applied to purify the small enclosure.

With reference to the following detailed description, these and other aspects and implementation aspects of this application will be better understood when considering the accompanying drawings and the scope of the patent application.

Detailed reference will be made to certain aspects and exemplary implementation aspects of this application, and examples in the attached structure and drawings are shown. Various aspects of this application are described in conjunction with exemplary embodiments, including methods, materials, and examples. This description is non-limiting, and the scope of this application is intended to include all equivalents known or incorporated herein. , Substitutes and modifications. Regarding the teachings in this application, any authorized patents, pending patent applications or patent application publications described in this application are fully incorporated herein by reference.

Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those commonly understood by those who are familiar with the disclosed methods and compositions. It must be noted that, as used in this document and the scope of the appended application, the singular forms "一 ("a", "an")" and "the (the)" include plural references unless the context clearly indicates otherwise . Thus, for example, reference to "a peptide" includes "one or more" peptides or "plurality" of such peptides.

Ranges can be expressed herein as from "about" one specific value, and/or to "about" another specific value. When expressing such a range, other embodiments include from the specific value and/or to the other specific value. Similarly, when a value is expressed as an approximate value by using the antecedent "about", it will be understood that the specific value forms another embodiment. It will be further understood that the endpoints of each range are important relative to the other endpoint and independent of the other endpoint. It should also be understood that many values are disclosed herein, and in addition to the value itself, each value is also disclosed herein as "about" the specific value. For example, if the value "10" is revealed, then "about 10" is also revealed. It should also be understood that when a value is disclosed, "less than or equal to the value", "greater than or equal to the value" and possible ranges between the value are also disclosed, as understood by those familiar with the art. For example, if the value "10" is disclosed, then "less than or equal to 10" and "greater than or equal to 10" are also disclosed.

As used herein, the term "ultrasonic cavitation" refers to the use of ultrasound to cavitation fluids such as cleaning fluids. Ultrasonic cavitation can be applied to the fluid by a series of methods and devices known to those skilled in the art, including high-pressure ultrasonic sprayers, ultrasonic nozzles or ultrasonic wafers. In this article, the term "ultrasound" means a sound frequency above the audible range, including any sound above 20 kilohertz.

In this article, the term "ultrasonic cavitation device" refers to a device used to perform ultrasonic cavitation on a clean fluid. Examples of ultrasonic cavities include high-pressure ultrasonic sprayers, ultrasonic nozzles or ultrasonic wafers. For example, a high-pressure ultrasonic sprayer atomizes liquid particles at a pressure of 50 to 400 bar to produce aerosol droplets. Ultrasonic nozzle is a type of nozzle that uses high-frequency vibration generated by a piezoelectric transducer to cavitation liquid. A preferred embodiment uses ultrasonic wafers. In one embodiment, the ultrasonic wafer is a ceramic diaphragm that vibrates at an ultrasonic frequency to generate water droplets. In another embodiment, the ultrasonic wafer is a small metal plate that vibrates at a high frequency to cavitation the liquid. Those with ordinary knowledge will understand that the choice of ultrasonic cavitation does not limit the scope of this application.

As used herein, the term "purification" means acting to neutralize or remove pathogens from an area or product. As used herein, the term "pathogen" includes, but is not limited to, bacteria, yeast, protozoa, viruses, or other pathogenic microorganisms. The term "pathogen" also includes targeted bioterror agents.

In this article, the term "bacteria" shall refer to a member of a large group of unicellular microorganisms which have cell walls but lack organelles and organized nuclei. Synonyms for bacteria can include the terms "microorganisms", "microbes", "germs", "bacilli" and "prokaryotes". Exemplary bacteria include, but are not limited to, Mycobacterium species, including M. tuberculosis; Staphylococcus species, including S. epidermidis, golden yellow Staphylococcus (S. aureus) and methicillin-resistant Staphylococcus aureus (methicillin-resistant S. aureus); Streptococcus species, including S. pneumoniae, Streptococcus pyogenes (S) pyogenes), Streptococcus mutans (S. mutans), Streptococcus agalactiae (S. agalactiae), Streptococcus equi (S. equi), Streptococcus canis (S. canis), Streptococcus bovis (S. bovis), Streptococcus equinus (S. equinus), Streptococcus anginosus (S. anginosus), Streptococcus sanguis (S. sanguis), Streptococcus salivarius (S. salivarius), Streptococcus light (S. mitis); other causes Species of the genus Streptococcus, including Enterococcus species, such as E. faecalis and E. faecium; Haemophilus influenzae (Haemophilus influenzae, Pseudomonas species, including P. aeruginosa, P. pseudomallei, and P. mallei; Salmonella species, including the small intestine S. enterocolitis (S. enterocolitis), S. typhimurium (S. typhimurium), S. enteritidis (S. enteritidis), S. bongori and S. choleraesuis (S. choleraesuis); Shigella species (Shigella) species), including S. flexneri (S. flexneri), S. sonnei (S. sonnei), S. dysenteriae (S. dysenteriae) and Shigella (S. boydii); Brucella Brucella species, including B. melitensis, B. suis, B. abortus, and B. pertussis (B. melitensis) pertuss is); Neisseria species, including N. meningitidis and N. gonorrhoeae; Escherichia coli, including enterotoxigenic large intestine Bacillus (enterotoxigenic E.coli, ETEC); Vibrio cholerae (Vibrio cholerae), Helicobacter pylori (Helicobacter pylori), Geobacillus stearothermophilus, Chlamydia trachomatis, Clostridium difficile ), Cryptococcus neoformans, Moraxella species, including M. catarrhalis, Campylobacter species, including C.jejuni ); Corynebacterium species, including C. diphtheriae, C. ulcerans, C. pseudotuberculosis, and C. pseudodiphtheriticum , Corynebacterium urealyticum (C. urealyticum), Corynebacterium hemolyticum (C. hemolyticum), Corynebacterium equi (C. equi); Listeria monocytogenes (Listeria monocytogenes), Nocardia stellate (Nocardia) asteroides), Bacteroides species, Actinomycetes species, Treponema pallidum, Leptospirosa species, Klebsiella pneumoniae; Proteus Genus (Proteus sp.), including Proteus vulgaris; Serratia species, Acinetobacter, Yersinia species, including Yersinia pestis Y. pestis and Y. pseudotuberculosis ; Francisella tularensis (Francisella tularensis), Enterobacter species, Bacteriodes species, Legionella species, Borrelia burgdorferi, etc. As used herein, the term "targeted bioterrorist" includes, but is not limited to, anthrax (Bacillus antracis), plague (Yersinia pestis) and tularemia (Francis tularensis).

As used herein, the term "virus" includes, but is not limited to, influenza virus, herpes virus, polio virus, norovirus and retrovirus. Examples of viruses include, but are not limited to, human immunodeficiency virus type 1 and 2 (HIV-1 and HIV-2), human T-cell lymphotropic virus type I and type II (HTLV-I and HTLV-II), A Hepatitis B virus, Hepatitis B virus (HBV), Hepatitis C virus (HCV), Hepatitis D virus (HDV), Hepatitis E virus (HEV), Hepatitis G virus (HGV), Parvovirus B19 virus, blood transfusion Transmission virus (TTV), Epstein-Barr virus, human cytomegalovirus type 1 (HCMV-1), human herpes virus type 6 (HHV-6), human herpes virus type 7 (HHV-7), human herpes Virus type 8 (HHV-8), influenza A viruses, including H1N1 and H5N1 subtypes, human metapneumovirus, acute severe respiratory syndrome (SARS) coronavirus, SARS-CoV-2, Middle East respiratory syndrome (MERS), hantavirus and from the arenaviridae family (such as Lassa fever virus (LFV)), pneumovirinae (such as human mesenchymal pneumonia virus), filoviridae (such as Ebola virus ), RNA viruses of Marburg virus (MBGV) and Zika virus); Bunyaviridae (for example, Rift Valley fever virus (RVFV), Crimean-Congo hemorrhagic fever virus (CCHFV) and Hanta virus) ; Flaviviridae (West Nile virus (WNV), Dengue virus (DENV), Yellow fever virus (YFV), GB virus type C (GBV-C; formerly known as G hepatitis virus (HGV)); Rotaviridae (Such as rotavirus), and their combination. In a specific embodiment, the space to be cleaned is contaminated with acute severe respiratory syndrome coronavirus 2 (SARS-CoV-2). In one embodiment, a system Infected with HIV-1 or HIV-2.

As used herein, the term "fungi" refers to any member of the eukaryotic group of saprophytic and parasitic spores, usually filamentous organisms, originally classified as plants lacking chlorophyll, and includes molds and rusts. ), mildews, smuts, mushrooms and yeasts. Exemplary fungi include, but are not limited to, Aspergillus species, Dermatophytes, Blastomyces derinatitidis, Candida species, including C. auris, Candida albicans (C. albicans) and Candida krusei (C. krusei); Malassezia furfur (Malassezia furfur), Exophiala werneckii (Exophiala werneckii), Piedraia hortai (Piedraia hortai) , Trichosporon beigelii, Pseudallescheria boydii, Madurella grisea, Histoplasma capsulatum, Histoplasma capsulatum, Pseudallescheria boydii, Madurella grisea Sporothrix schenckii), Histoplasma capsulatum (Histoplasma capsulatum), ringworm (Tinea species), including tinea versicolor (T. versicolor), athlete's foot (T. pedis), onychomycosis (T. unguium), tinea cruris (T cruris), tinea capitis (T. capitus), tinea corporis (T. corporis), tinea corporis (T. barbae); Trichophyton species, including T. rubrum, interdigital Trichophyton (T. interdigitale), Trichophyton (T. tonsurans), Trichophyton purple (T. violaceum), T. yaoundei (T. yaoundei), T. schoenleinii (T. schoenleinii), Trichophyton megninii (T. megninii), Trichophyton sudanense (T. soudanense), Trichophyton equinum (T. equinum), T. erinacei and Trichophyton verrucosa ( T. verrucosum); Mycoplasma genitalia; Microsporum species, including M. audouini, M. ferrugineum, dog small M. canis, M. nanum, M. distortum, M. gypseum, M. fu lvum) etc.

In this article, the term "protozoa" shall mean any member of multiple groups of eukaryotes. The eukaryotes are mainly single-celled, live alone or aggregate into colonies, usually non-photosynthetic, and usually based on them The exercise ability and methods are further classified by pseudopodia, flagella or cilia. Exemplary protozoa include, but are not limited to, Plasmodium species, including P. falciparum, P. vivax, and P. ovale ) And Plasmodium vivax (P. malariae); Leishmania species (Leishmania species), including L. major (L. major), tropical Leishmania (L. tropica), Leishmania donovani (L. donovani), Leishmania infantum (L. infantum), Leishmania chagasi (L. chagasi), Leishmania mexicana (L. mexicana), Panama Leishmania (L. panamensis), Brazilian Leishmania (L. braziliensis) and Guyanensi (L. Guyanensi); Cryptosporidium (Cryptosporidium), Isospora (Isospora) belli), Toxoplasma gondii (Toxoplasma gondii), Trichomonas vaginalis (Trichomonas vaginalis) and Cyclospora species.

In this article, the term "product" refers to any solid article or object that may be easily contaminated by pathogens. In this article, the term "substantially enclosed space" refers to a room, tent, building or any man-made structure that is substantially enclosed and may be easily contaminated by pathogens. The term "substantially enclosed space" is not limited to man-made structures, even though the implementation mode shown here is preferably about purifying such structures.

As used herein, the term "sensor" can refer to any type of sensor suitable for detecting pollution on equipment, surfaces or in substantially enclosed spaces. Examples of sensors include, but are not limited to, photoelectric sensors, current sensors, weight sensors, humidity sensors, pressure sensors or any type of biological sensors.

As used herein, the term "shearing" refers to the process of using force to break liquid particles into discrete groups. The discrete groups move and flow as independent subgroups of the sheared particles until the particles The groups transform into mist in the fluid phase. In this article, the term "fog" refers to a cloud of aerosol droplets. As used herein, the term "aerosol" refers to a colloid of fine droplets with a diameter of about 1 to about 20 microns.

As used herein, the term "cleaning fluid" refers to the source of active substances (species) used to purify products or substantially enclosed spaces. The preferred active material is hydroxide ion, and the preferred source is hydrogen peroxide. This source can be replaced with more complex substances that generate hydroxide ions during reaction or decomposition. Examples of such more complex substances include peracetic acid (CH ₂ COO-OH + H ₂ O), sodium percarbonate (2Na ₂ CO ₃ + 3H ₂ O ₂ ), and glutaraldehyde (CH ₈ O ₂ ). The cleaning fluid may further include a promoting substance that helps the active substance complete its attack on biological microorganisms. Examples of such promoting substances include ethylenediaminetetraacetate, isopropanol, enzymes, fatty acids and acids. Any operable type of clean flow system. The cleaning fluid must contain activatable substances. The preferred cleaning fluid contains a source of hydroxide ions (OH ⁻ ) for subsequent activation. Such sources can be hydrogen peroxide (H ₂ O ₂ ) or precursors that produce hydroxide ions. Other sources of hydroxide ions can be used as appropriate. Examples of other operable hydroxide ion sources include peracetic acid (CH ₂ COO--OH+H ₂ O), sodium percarbonate (2Na ₂ CO ₃ +3H ₂ O ₂ ) and glutaraldehyde (CH ₈ O ₂ ). Other activatable substances and sources of the other activatable substances can also be used. In some embodiments, by using water for injection (WFI) to generate ionic particles activated by an electric arc, compared to an untreated control, more than 3-log ¹⁰ of bacteria, bacterial spores or virus particles can be killed.

The cleaning fluid can also contain promoting substances, which are not the source of activatable substances (such as hydroxide ions), but change the purification reaction in a beneficial way. Examples include: ethylenediaminetetraacetic acid (EDTA), which binds metal ions and allows activated substances to more easily damage the cell wall; alcohols, such as isopropanol, can improve the moisturizing effect of fog on cells; enzymes, which accelerate or strengthen the activated substances Attack the redox reaction of the cell wall; fatty acids, which act as auxiliary antimicrobial, can combine with free radicals to produce residual antimicrobial activity; and acids, such as citric acid, lactic acid or oxalic acid, which accelerate or strengthen the redox reaction, and can act as Auxiliary antimicrobial substance for pH-sensitive organisms. Mixtures of various activatable substances and various promoting substances can also be used. The cleaning fluid is preferably an aqueous solution, but can also be a solution of organic matter (such as alcohol). The source of the cleaning fluid may be the source of the cleaning fluid itself, or the source of the cleaning fluid precursor that is chemically reacted or decomposed to produce the cleaning fluid.

As used herein, the term "non-thermal plasma activator" refers to an activator that activates a cleaning fluid to an activated state such as ionization, plasma, or free radicals. As time goes by, the activated state returns to the non-activated state ( This is called the "recombination" process). In order to complete the activation, the activator generates activation energy, such as electrical energy or photon energy. Photon energy can be generated by laser. Examples of activators include AC electric field, AC arc, DC electric field, DC arc, electron beam, ion beam, microwave beam, radio frequency beam and ultraviolet beam. The activator may include a tuner that adjusts the amplitude, frequency, waveform, or other characteristics of the activation energy to achieve the desired (usually the maximum) recombination time of the activated clean fluid mist. As used herein, the term "plasma-activated ionic particles" refers to activated OH ^- ions.

In this article, "closed space" refers to any chamber, container or space that can be purified by the system of the present disclosure. Examples of enclosed spaces include, but are not limited to, any chambers used in daily to highly controlled research projects/spaces, health rooms (such as gynoprobe cabinets), BSC, glove boxes, research covers, and clinics space. System for purifying airborne pathogens in a substantially enclosed space

One aspect of this application is a system for purifying a substantially enclosed space, including: a sensor for airborne pathogens, wherein the sensor communicates with a computer processor through a network; a computer processor, wherein the computer processor and the sensor Detector and purification equipment network communication; purification equipment, wherein the purification equipment communicates with the computer processor, and further wherein the purification equipment includes: a clean fluid reservoir; an ultrasonic cavitation, wherein the ultrasonic cavitation is immersed in the storage In the warehouse; non-thermal plasma activator, wherein the activator activates the mist generated from the storage; funnel, wherein the funnel connects the non-thermal plasma activator to the storage; outer tube, wherein the outer tube connects the non-thermal activator To the outside atmosphere; and wherein the fog generated from the storage can reach the activator through the funnel, and further wherein after the fog is activated by the activator, the fog can reach the outside atmosphere through the outer tube.

In an exemplary embodiment, the computer system includes a memory, a processor, and an auxiliary storage device as needed. In some embodiments, the computer system includes a plurality of processors and is configured as a plurality of blade servers or other known server configurations. In a specific implementation aspect, the computer system also includes input devices, display devices, and output devices. In some embodiments, the memory includes RAM or similar types of memory. In certain implementations, the memory stores one or more application programs for execution by the processor. In some implementation aspects, the auxiliary storage device includes a hard disk drive, a CD-ROM or DVD drive, or other types of non-volatile data storage. In certain implementations, the processor executes applications stored in memory or auxiliary storage devices or received from the Internet or other networks. In some implementation aspects, the processing of the processor can be achieved by software (such as a software module) so as to be executed by a computer or other machine. These application programs preferably include instructions executable to perform the functions and methods described above and shown in the drawings herein. The application program preferably provides a GUI through which the user can view and interact with the application program. In other implementation aspects, the system includes remote access to control and/or view the system.

In a further implementation aspect, the purification system can be connected to the building HVAC system for indoor isolation and ventilation. The purification system uses automated equipment to purify any enclosed area, and provides downloadable disinfection/purification operation data and real-time measurement of injection rate to ensure targeted injection volume. According to the room size and usage, the purification system can cover multiple rooms and customize specifications as needed. In another embodiment, the purification system is included in a handheld device for use in life science facilities. The device is designed to be used by technicians, using the trigger on the device to control its use according to the trigger position. In some embodiments, a system for purifying spaces (including small enclosures) contaminated by viruses (for example, SARS-CoV-2) includes purification equipment and computer processors, among which the computer processor and the purification equipment Network communication, in which the input parameters of the small enclosure space are input into the computer processor, and the computer processor is programmed to determine the fluid characteristics of the cleaning fluid in the purification equipment based on the input parameters of the small enclosure space, where the computer processor It is further programmed to start the purification cycle of the purification equipment. The purification cycle includes the following steps: providing a reservoir of the cleaning fluid; setting the fluid characteristics of the determined cleaning fluid; generating an extremely dry cleaning fluid containing ionized hydrogen peroxide Mist, in which the generated extremely dry mist is applied to purify a substantially small enclosing body space, and in which the determined fluid characteristics of the cleaning fluid are set by controlling the air valve. The purification cycle for the space contaminated by the virus is executed at least four times, each cycle is 60 seconds apart; each cycle lasts at least 90 seconds, and the spray pulse of at least 20 seconds is separated at 10 second intervals. The air pressure is reduced sufficiently below the standard pressure range (for example, 25 to 50 psi) to 15 psi, and the fluid flow rate is also reduced sufficiently below the standard range of flow rate (for example, 25 to 50 ml/min) to 10 to 12 ml/min. The cleaning fluid can be supplemented with amphiphiles (such as surfactants) to enhance virus purification. Method and equipment for purifying using activated cleaning fluid mist

As disclosed in US Patent No. 6,969,487 (which is incorporated herein by reference), the method for performing purification includes the following steps: generating an activated cleaning fluid mist, wherein at least a portion of the cleaning fluid mist is in an activated state, and the activation The clean fluid mist contacts the location to be purified.

Figure 1 depicts the preferred method of purification. Produce an activated clean fluid mist, mark 20. Any operable method can be used, and the preferred method is shown in step 20 in Figure 1. Provide a source of clean fluid, label 22. The cleaning fluid is preferably a liquid, which can be evaporated in the air under ambient pressure by any force or energy method to form a mist. Liquid cleaning fluids can be stored at atmospheric pressure or a slightly higher pressure, while gaseous cleaning fluids usually need to be stored under pressure. The source of the cleaning fluid can also be a precursor of the cleaning fluid, such as a solid, liquid, or gas, which reacts, decomposes, or otherwise generates the cleaning fluid.

Produces a clean fluid mist containing activatable substances and promoting substances (if any), number 24. The mist generator for generating mist of clean fluid can be of any operable type. In a better case, the cleaning mist or steam is the tiny droplets of the evaporated cleaning fluid. In some embodiments, the size of the droplets is preferably approximately uniform, on the order of about 1 to about 20 microns in diameter. In other embodiments, the size of the droplets is preferably approximately uniform, on the order of about 1 to about 10 microns in diameter. In other embodiments, the size of the droplets is preferably approximately uniform, on the order of about 1 to about 5 microns in diameter. In other embodiments, the size of the droplets is preferably approximately uniform, on the order of about 2 to about 4 microns in diameter. Various types of fog generators have been used in prototype research.

The cleaning fluid mist is activated to produce an activated cleaning fluid mist, number 26. The activated substance is activated in the mist to generate the cleaning fluid material, such as the cleaning fluid material in the ionized, plasma or free radical state. At least a portion of the activatable substance is activated, and in some cases, some promoting substances (if any) are activated. High-yield activating substances are needed to improve the efficiency of the purification process, but not all or even most activatable substances must reach the activated state. Any operable activator can be used. The activator field or beam can be electrical or photonic. Examples include AC electric fields, AC arcs, DC electric fields, DC arcs, electron beams, ion beams, microwave beams, radio frequency beams, and ultraviolet beams generated by lasers or other sources. The activator causes at least some activatable substances of the cleaning fluid in the cleaning fluid mist to be excited into an ion, plasma or free radical state, thereby achieving "activation". These activated substances undergo redox reactions with the cell walls of microbial organisms, thereby destroying cells or at least preventing their reproduction and growth. In the preferred case of the hydrogen peroxide, at least some H ₂ O ₂ molecules dissociate to produce hydroxyl (OH ^-) and monatomic oxygen (O ^-) ion activation species. The activated substances remain dissociated for a period of time, usually a few seconds or longer, during which they attack and destroy biological microorganisms. The activator is preferably adjustable for the frequency, waveform, amplitude or other characteristics of the activation field or beam, so that it can be optimized to achieve the maximum recombination time for biological microorganisms. In the case of hydrogen peroxide, the dissociated activated substances recombine to form diatomic oxygen and water, which are harmless molecules.

The physical relationship between the mist generator and the activator can be of several types. Figures 2 to 4 schematically show three types of purification equipment 38. In each case, the cleaning fluid source 40 provides a flow of cleaning fluid to the mist generator 42. The mist generator forms a clean fluid mist 44 of clean fluid. The cleaning fluid mist 44 contains activatable substances and promoting substances (if any). In the embodiment of Figure 2, the activator 46 is schematically shown as a pair of discharge plates (the cleaning fluid mist 44 passes therethrough), which is located near the mist generator 42 and preferably adjacent to the mist generator 42 . In this case, the mist generator 42 and the activator 46 are usually packaged in a housing for convenience. The cleaning fluid mist 44 leaving the mist generator 42 is immediately activated by the activator 46 to generate an activated cleaning fluid mist 48. In the embodiment shown in FIG. 3, the activator 46 is schematically shown here as a set of microwave sources, which is located far away from the mist generator 42. The cleaning fluid mist 44 flows out from the mist generator 42 and remains as an unactivated cleaning fluid mist for a period of time, and then enters the area affected by the activator 46 and activated by the activator 46. The two embodiments can be combined as shown in Figure 4, where the cleaning fluid mist 44 is initially activated by the activator 46a close to the mist generator 42 to form an activated cleaning fluid mist 48, and then remains in the activated state or according to It needs to be reactivated by the activator 46b away from the mist generator 42. In this case, the activator 46b is exemplified as an ultraviolet light source. The device of Figure 4 has the advantage that the cleaning fluid is initially activated and then kept in the activated state for an extended period of time to reach the extended effective state. According to the physical constraints of each situation, the various types of equipment 38 are used in different situations, and some example situations are discussed later. Particle and/or gas filters can be provided at appropriate locations to remove particulate matter as a carrier of microbial organisms, as well as to remove residual cleaning mist and its reaction products.

The activated cleaning fluid mist 48 is brought into contact with the position to be purified, number 28. The types of locations and contact methods lead to many specific implementations of the aforementioned general methods, as described below.

Figure 5 shows the flow form of the purification device 38. This type of equipment usually uses the general configuration shown in Figure 2, where the activator 46 is located near the mist generator 42. It does not require a shell, although it can be used in the shell. Figure 5 and other figures show specific implementations of the device. Common elements of the structure will be given the same reference numerals as elsewhere, and other descriptions are incorporated into the description of each implementation. The cleaning fluid from the cleaning fluid source 40 is supplied to the mist generator 42 and the cleaning fluid mist 44 flows out from the mist generator 42. The cleaning fluid mist 44 flows through the inside of the tube 50, and the tube 50 guides and directs the flow of the cleaning fluid mist 44. When the cleaning fluid mist 44 flows through the inside of the tube 50, the activator 46 powered by the voltage source 52 activates the cleaning fluid mist 44, so that the activated cleaning fluid mist 48 flows out from the tube 50 as a flow. Direct the flow to the volume or object to be purified.

In one embodiment, for example, the voltage source 52 is connected to an adjustable voltage divider, such as a potentiometer. The potentiometer may include a housing containing a resistance element and a contact sliding along the resistance element, two electrical terminals at the two ends of the resistance element, and a mechanism for moving the sliding contact from one end to the other. The potentiometer used can be a circular slider potentiometer, a pad slider potentiometer, or any other suitable slider arrangement can be used. For example, the potentiometer may include a resistance element made of graphite, plastic containing carbon particles, resistance wire, or a mixture of ceramic and metal.

The included potentiometer allows the user to control the fluid flow rate of the cleaning fluid mist 44 flowing through the tube 50. As a result, the reduced air pressure can reduce the size of the mist particles produced. The potentiometer can be controlled by the control unit to adjust the input of the circuit for the voltage source 52.

The basic configuration shown in Figure 5 can be expanded in a wide range of sizes. In one example, the cleaning fluid source 40 is a handheld pressure tank commonly used for dispensing fluid or gas. In another example, for example, the cleaning fluid source 40 operates on two platforms. One platform can be a hand-held spot spray surface purification device, and the other platform can be a programmable automated environmental purification device designed for small enclosures. The hand-held spot spray feature allows manual control of the purification effect. Programmable automation allows input of surrounding parameters for predictable and consistent operation in the best arrangement that matches the geometry of the purification enclosure.

The voltage source 52 is a battery and a circuit for providing a high voltage to the activation source 46 for sufficient time to activate the amount of clean fluid stored in the pressure tank. The pipe 50 is the nozzle of the pressure tank. In another example, the tube 50 is a hand-held wand that is operated by a larger volume cleaning fluid source 40 and a plug-in or battery voltage source 52. The cleaning fluid source 40 may be pressurized to drive the flow of cleaning fluid through the tube 50, or an optional pump 54 may be provided, which forces the cleaning fluid through the mist generator 42 and out of the tube 50 with great force.

In a programmable device, the control unit can be programmed to send commands based on desired fluid parameters to adjust the potentiometer and control the pump 54. For example, in a very small enclosure, a drier fog may be generated so that the fog travels a shorter distance. This can be achieved by reducing the standard air pressure or standard fluid flow rate of the purification equipment. The standard air pressure input to the programmable control unit can be 25 to 50 pounds per square inch, and the input standard air pressure range can be modified as needed. In addition, the standard fluid flow rate input to the programmable control unit can be 25 to 50 ml/min, and the input standard fluid flow rate range can be modified as needed.

Compared with programmable devices, hand-held surface purification equipment can be manually operated by pressing a trigger on the hand-held applicator to generate a purification fluid, such as ionized hydrogen peroxide mist. In one example, the fluid or air settings are not programmable, but are manually controlled by the user based on the actual limits of the enclosure.

Other forms of the equipment 38 are mainly used in combination with the enclosure to enclose purification treatments or objects or flows, or to achieve purification inside the enclosure. Figure 6 shows a device 38 containing an enclosure 56 which serves as a chamber in which objects 58 are cleaned. The object 58 may be stationary, or it may move through the enclosure 56 on a conveyor. This embodiment also shows the form of the device, in which an activated cleaning fluid mist 48 is added to another air stream 60 and mixed with it. The activated cleaning fluid mist 48 is mixed with the air flow 60, and the mixed air flow contacts the object 58. This embodiment can be implemented as a continuous flow system as shown in the figure, or as a batch system, in which the enclosure 56 is filled with an activated cleaning fluid mist 48 or a mixture of activated cleaning fluid mist 48 and gas 60 in a batch manner .

In the embodiment shown in Fig. 7, the enclosure 56 is formed by walls, floors, and ceilings of rooms or other structures such as vehicles. The activated cleaning fluid mist is generated by an integrated device of the type shown in Figure 4, in which the mist generator 42 and the activator 46a are packaged together as a single unit. An optional second activator 46b is provided and used in a manner related to the description in Figure 4, the disclosure of which is incorporated herein. The second activator 46b keeps the activated cleaning fluid mist in the activated state for an extended period of time, so as to allow the room to be completely cleaned. The second activator 46b may be built in the wall, floor or ceiling of the enclosure 56, or they may be provided as a portable unit, only in the enclosure 56 during the purification process. The purification device 38 in Figure 7 purifies the inner walls of rooms, vehicles or other structures, as well as objects and humans therein. The type of equipment 38 shown in Figure 7 can be used to clean rooms in fixed homes, offices, or other facilities, or the interior of mobile vehicles, such as the interior of airplanes, automobiles, ships, or military vehicles. The enclosure 56 may also be a protective clothing worn by the decontamination personnel, so as to provide continuous purification of its interior in the case of normal operation or leakage in the protective clothing.

Fig. 8 shows an implementation mode in which the mist generator 42 and the activator 46 are built-in or temporarily inserted into the enclosure 56 in the form of a duct of the HVAC system. The pipe 62 may be a part of the main pipe of the HVAC system, or it may be an auxiliary pipe added to the HVAC system for receiving the purification equipment 38. The filter 64 is arranged downstream of the mist generator 42 and the activator 46 to remove particles and any remaining mist. The filter 64 may be, for example, a known type of porous carbon, low-restriction coalescing filter (low-restriction coalescing filter).

As shown in the embodiment in Figure 8, in addition to solid objects, the purification device 38 can also be used to purify air and other airflows. Figure 9 shows an embodiment in which the purification device 38 is used as a gas mask to provide people with purified breathing air. The enclosure 56 is configured as a canister with an air inlet and an outlet, the outlet providing air to the mask 66 placed on the face. The mist generator 42 injects the cleaning fluid mist into the incoming air. The position of the activator 46 can be set to activate the cleaning fluid mist in the manner shown in FIG. 2. In addition, in this case, the activator 46 is located downstream of the air inlet, so that the cleaning fluid mist is mixed with the incoming air first, and then is activated by the activator 46. The filter 64 is provided as previously described to remove particles and any liquid residue of the mist.

Some implementation aspects of the present disclosure are operated at an ambient pressure of about one atmosphere or slightly higher than one atmosphere, all of which are within the range of "substantially one atmospheric pressure." As mentioned earlier, this ability is very important because most purification situations require the ability to achieve purification without a vacuum chamber or pressure chamber. When the mist generator enters an atmospheric pressure environment, it will produce a small mist overpressure, but it does not require a vacuum or pressure chamber. Especially in the embodiments shown in Figs. 3, 4, 6, 8, and 9, particulate matter can be removed from the contaminated area or contaminated air flow and collected on the filter, Thereby removing the carrier medium of the microbial organism and destroying the exposed microbial organism itself. Purification method

One aspect of this application relates to a method of purifying an article or a substantially enclosed space, comprising the steps of: shearing the cleaning fluid into a mist containing aerosol droplets, which accumulates on the top of the substantially enclosed chamber The chamber part, the chamber includes a funnel-shaped top chamber part, a bottom chamber part, a side chamber part and an inner chamber part, in which the cleaning fluid is sheared by ultrasonic cavitation; the mist is subjected to non-thermal plasma The activator is used to form plasma-activated ion particles; and make the product or a substantially enclosed space contact the plasma-activated ion particles. Those with ordinary knowledge will understand that factors such as the form of a funnel-shaped top chamber or the method of aerosolization of plasma-activated ion particles are not limiting to this application.

Another aspect of this application relates to a method of purifying an article or a substantially enclosed space, comprising the following steps: using an ultrasonic cavitation immersed in a substantially enclosed chamber containing the cleaning fluid to empty the cleaning fluid The cleaning fluid is cut into a mist containing aerosol droplets; in the outlet tube extending from the opening in the top chamber portion of the substantially closed chamber, the mist is subjected to a non-thermal plasma activator, wherein the outlet tube Contains a hollow cavity with a distal opening above the top chamber portion for discharging aerosol droplets to form plasma-activated ion particles; and to make the product or a substantially enclosed space and plasma-activated ion particles contact.

Another aspect of this application is a method for purifying products or substantially enclosed spaces, comprising the following steps: immersing an ultrasonic cavitation device in a reservoir of clean fluid; using ultrasonic vibration generated by the ultrasonic cavitation device Cavitation of the cleaning fluid; generating a mist containing aerosol droplets, wherein the mist is generated from the cleaning fluid while the cleaning fluid is cavitation; the mist is subjected to a non-thermal plasma activator to form plasma-activated ion particles; and the plasma The activated ion particles come into contact with pathogens.

Another aspect of this application relates to a method for purifying an article or a substantially enclosed space, comprising the following steps: providing a reservoir of cleaning fluid; cavitation of the cleaning fluid reservoir by applying force to the cleaning fluid; A mist of aerosol droplets, in which a mist is generated from the cleaning fluid while the cleaning fluid is cavitation by force; the mist is subjected to a non-thermal plasma activator to form plasma-activated ionic particles; and plasma-activated ions The particles are in contact with pathogens.

The present disclosure provides a method for purifying products or substantially enclosed spaces by ultrasonic cavitation. This application discloses that the use of ultrasonic cavitation in a clean fluid accidentally results in a low-pressure, low-fluid flow mist. Once the mist is activated, it significantly enhances the killing effect and the ability to purify a tightly enclosed environment. Because no air compression is required, this method also advantageously reduces the complexity of the machines used in the purification process. purifying facility

The exemplary purification equipment/system of the present disclosure includes an applicator with a cold plasma arc, which splits a hydrogen peroxide-based solution into reactive oxygen species including hydroxide radicals, which seeks and kills Death and inactivation of pathogens. The activated particles produced by the applicator kill or inactivate a wide range of pathogens and are safe for sensitive equipment. Generally, the purification equipment/system of the present disclosure allows effective treatment of an exemplary space measured by 104 square meters (m ² ) within about 75 minutes including application time, contact time, and ventilation time. The purification equipment/system of the present disclosure can be expanded and configured to be effective in any size or volume of space/room/chamber/container. Scalability can be achieved by the size of the device, by manual control of the purified fluid, or by programming the device air pressure and subsequent fluid flow rate as a function of input space/room/chamber/container parameters.

Example spaces include, but are not limited to, clean rooms, research laboratories, production environments, service and technical areas (HEPA filters), material passage rooms, corridors, and passages. The purification equipment/system of this disclosure is suitable for areas ranging from a single space to the entire building. The plasma activated ion particles produced by this equipment or system are non-caustic and silver-free. Generally, the fog generated by the device or system moves through a closed space or moves over a surface. Exemplary surfaces that can be purified include, but are not limited to, safety cabinets, general laboratory equipment, isolators, HEPA filters, animal breeding boxes, and decommissioned equipment.

Another aspect of this application relates to miniature purification equipment, which includes DCV miniature transformers and/or DCV miniature compressors to reduce power requirements and the total weight and size of the equipment. In some embodiments, the mini-purification equipment can be from the size of a lunch box to the size of a backpack, and/or have a weight of 10 to 40 pounds. In some implementation aspects, the micro purification device is placed in a backpack, a lightweight carrying case, or on a wheeled cart. In some embodiments, the device includes a cell system that heats the purification solution to cause evaporation before passing through the arc system. In a specific embodiment, the device includes a portable wheeled system (similar to the form of an IV bracket system) that runs on a rechargeable battery.

In some embodiments, the DCV micro-transformer has an input DC voltage of 6 to 36 volts and generates an output of 12 to 22.5 kV. In some embodiments, the DCV micro-transformer has an input DC voltage of 24 volts and generates an output of 17.5 kilovolts.

In some embodiments, the DCV micro compressor provides a pressure of 10 to 60 psi and has an input DC voltage of 6 to 36 volts. In some embodiments, the DCV micro-compressor provides a pressure of 30 to 40 psi and has an input DC voltage of 24 volts.

In some implementations, the miniature purification equipment further includes a diode/capacitor rectifier, which smoothes the arc conversion process and improves the conversion efficiency in AC.

In some embodiments, the micro purification device further includes a low-flow pump, which has a flow rate of 4 to 40 ml/min and a working voltage of 6 to 36 VDC.

In some implementation aspects, the micro purification device further contains a control module, which allows remote devices such as a tablet computer or a phone to control (for example, start and/or stop the device) and monitor the micro purification device. In some implementation aspects, the control module further controls data storage, transmission, and printing.

Another aspect of this application relates to a miniature purification equipment, which includes a miniature transformer and an ultrasonic wafer or an ultrasonic sprayer as a mist generator. In some embodiments, the mist generator includes a substantially enclosed ultrasonic treatment chamber, which includes a funnel-shaped top chamber part, a bottom chamber part, a side chamber part, and an inner chamber part, wherein the cleaning fluid Cut by ultrasonic cavitation in the ultrasonic processing room. In some embodiments, the device includes more than one ultrasonic wafer. In some other embodiments, the device includes 2, 3, 4, 5, 6, 7, 8, 9 or 10 ultrasonic wafers.

In some embodiments, the purification equipment has a modular structure, which reduces the footprint of the equipment and allows modules to be exchanged between different equipment.

In some embodiments, the purification equipment further includes a low-flow pump with a flow rate of 4 to 40 ml/min and an operating voltage of 6 to 36 VDC or 10 to 28 VDC.

In some implementation aspects, the purification device further contains a control module, which allows remote devices such as a tablet computer or a phone to control (for example, start and/or stop the device) and monitor the mini purification device. In some implementation aspects, the control module further controls data storage, transmission, and printing. In some implementations, the control module allows remote services and connections, is used to record video or data, and is used to provide feedback to the user during or after use.

In some embodiments, the purification equipment is installed on a rotating base that allows better coverage of the area to be purified, as shown in the graphs in Figures 10A to 10D. In some embodiments, the rotating base is a 180-degree rotating base. In some embodiments, the rotating base is a 360-degree rotating base. In some embodiments, the rotating base is an adjustable rotating base with a rotation range of 60 to 360 degrees. In some embodiments, the rotation system surrounds a single axis. In other embodiments, the rotation system revolves around multiple axes. In still other embodiments, the rotation is in all directions or a completely spherical motion. FIG. 10A shows the configuration of equipment components, in which the cleaning fluid source 40 and the mist generator 42 are connected by an activation device 70, which has an adjustable rotation range of up to 360 degrees. Figure 10B shows the configuration of the equipment components, in which the cleaning fluid source 40 is connected to the mist generator 42, and the mist generator 42 is connected to the mist delivery unit 72 through the activation device 70. The activation device 70 has an adjustable rotation range of up to 360 degrees . Figure 10C shows the configuration of the equipment components. The mist generator 42 is mounted on the activation device 70, which has an adjustable rotation range of up to 360 degrees. FIG. 10D shows another configuration of the equipment components, in which the mist generator 42 is fed into the mist delivery unit 72, and the mist delivery unit 72 is installed on the activation device 70, which has an adjustable rotation range of up to 360 degrees.

Figures 11A to 11C depict exemplary implementations of portable or portable purification equipment. This description is not intended to show the components of the device in fixed positions in the portable unit, but the placement of the various components shown is only exemplary, and the positions of the components can be rearranged to suit a specific application. FIG. 11A depicts an implementation aspect in which at least the mist generator 42 and the voltage source 52 are contained in a portable housing. In some embodiments, the voltage source 52 is AC. In other embodiments, the voltage source 52 is DC. In still other embodiments, the voltage source 52 can be switched between AC and DC. The mist generator 42 is functionally connected to the mist delivery unit 72, and the mist delivery unit 72 can be mounted on the housing or attached to a remote unit. In some embodiments, the mist delivery unit 72 is handheld, installed on another device, or held by or installed on another machine or robot. In some other implementations, the robot is self-navigating and patrolling an area. Figure 11B depicts the mist generator 42 and the voltage source 52 contained in a portable container, where the entire unit can be handheld, installed on another device, or held by another machine or robot or installed in another On a machine or robot. In some embodiments, the voltage source is AC. In other embodiments, the voltage source 52 is DC. In other embodiments, the voltage source can be switched between AC and DC. In a specific embodiment, the mist is dispersed from the unit by the high-pressure activator 100. In some embodiments, high pressure activation is continuous. In other embodiments, the high-pressure activation is intermittent. In certain embodiments, the high voltage activation charges the mist and further atomizes the droplets. FIG. 11C depicts an exemplary implementation, in which the mist generator 42 and the voltage source 52 are contained in a wearable container (such as a backpack). The mist generator 42 is functionally connected to the mist delivery unit 72, and the mist delivery unit 72 can be mounted on the container or a remote unit. In some embodiments, the mist delivery unit 72 is handheld, installed on another device, or held by or installed on another machine or robot.

As shown in Figure 12A, in some embodiments, the purification device includes an ultrasonic wafer or an ultrasonic sprayer 82 as a mist generator. In some embodiments, the mist generator 42 includes a substantially enclosed ultrasonic processing chamber, which includes a bottom chamber portion or reservoir, formed in the top chamber portion of the channel between the bottom chamber portion and the plasma activator 76 74. The voltage source 52 includes the side chamber part and the inner chamber part of the cleaning fluid source 40, wherein the ultrasonic cavitation generated by the ultrasonic cavitation device 78 in the ultrasonic processing chamber shears the cleaning fluid distributed to the sprayer 82 80. The cleaning fluid 80 is introduced into the fluid chamber or reservoir until it is submerged in the ultrasonic cavitation device 78. The ultrasonic cavitation device 78 generates resonant ultrasonic waves for cavitation of the clean fluid and generates aerosol droplets rising from the fluid through the passage 74. The mist passes through the applicator head and plasma activator, or electrode 76, where the particles are activated before entering the outside atmosphere. In some implementations, a fan can be used to guide the flow of fog. In some embodiments, the device includes a rotary applicator based on a small circulating fan. In other embodiments, the device includes an independent applicator, which includes an air compressor, a fluid pump, and a transformer. In some embodiments, the heating element heats the inner space to spread the atomized mist. In some embodiments, the device includes a rotating head or nozzle.

The channel can take any form suitable for guiding the aerosol droplets from the reservoir to the plasma activator 76. In some embodiments, the channel is in the form of a funnel. In other embodiments, the channel can be in the form of a pipe, a pipe, an elbow or a cylinder, but it is not limited thereto.

In some embodiments, the plasma activator is non-thermal. In other embodiments, the plasma activator is hot.

FIG. 12B shows a system in which the mobile/wireless/remote control device 84 is functionally connected to the purification device of the present disclosure, such as the sprayer 82. Functional connections can be wired or wireless. In some embodiments, the wireless connection includes, but is not limited to, radio frequency, infrared, wifi, Bluetooth, or any other suitable wireless communication means. In some embodiments, the control device 84 sends the control command 86 to the sprayer 82 via the functional connection, and the sprayer 82 sends the feedback data 88 to the control device 84 via the functional connection. Figure 12C shows an implementation aspect of the system, where the system includes a plurality of purification devices, such as sprayers 82, which are controlled by the control device 84, and further conduct two-way communication between the sprayers 82 by wired or wireless means 90. In some embodiments, the system may have a single control unit 84 that controls multiple sprayers 82 located in different areas and/or different rooms of the room to be disinfected/purified, and/or attached to, or For different parts of equipment that need to be disinfected/purified, such as flow hoods. Those with general knowledge will understand that the devices can be individually, or sequentially, or wirelessly networked to the control unit, and the network arrangement described herein is not limiting.

Figures 13A to 13B depict a similar system with a single (Figure 13A) or multiple (Figure 13B) fog generators 42, wherein the two-way communication 92, 96 is controlled by the control device 84, and the control device 84 further Provide data from external sources for area or surface treatment 94. Those with general knowledge will also understand that the device can be individually, or sequentially, or wirelessly networked to the control unit, and the network arrangement described herein is non-limiting.

FIG. 14 shows a system in which the mist generator 42, the cleaning fluid source 40, and the mist delivery unit 72 are further connected to the sensor 98. In some embodiments, the sensor 98 detects airborne or surface-contaminated microorganisms (such as bacteria, parasites, amoeba, or virus particles). In some implementations, the sensor 98 automatically triggers the execution of the system when a pollutant is detected.

Another aspect of this application relates to a purification device that includes a diode/capacitor rectifier, which smoothes the arc conversion process and improves conversion efficiency. Figure 15 shows an exemplary rectifier, which includes a voltage source 52, and at least one diode/capacitor 102 connected to a non-thermal plasma activator 76.

Traditional purification methods are not effective in purifying small enclosures. This application discloses the use of extremely dry mist containing ionized hydrogen peroxide for purification in small enclosures, semi-enclosed spaces and enclosed areas (small enclosures are 12"x12"x12" or smaller; semi-enclosed Space is an area where part of the small enclosure is open to other areas; closed area is an area where no part of the small enclosure is open to other areas) provides unexpectedly high levels of pathogens (including bacteria, fungi, native Animals or viruses), such as the killing rate of Candida in the ear canal.

Extremely dry mist is this kind of mist: the particle size is about 0.1 to 0.2 microns, 0.1 to 0.3 microns, 0.1 to 0.4 microns, 0.1 to 0.5 microns, 0.1 to 0.6 microns, 0.1 to 0.7 microns, 0.1 to 0.8 microns, 0.1 to 0.9 microns, 0.1 to 1 microns, 1 to 1.1 microns, 1 to 1.2 microns, 1 to 1.3 microns, 1 to 1.4 microns, 1 to 1.5 microns, 1 to 1.6 microns, 1 to 1.7 microns, 1 to 1.8 microns, 1 to 1.9 microns, 1 to 2 microns, 0.5 to 0.6 microns, 0.5 to 0.7 microns, 0.5 to 0.8 microns, 0.5 to 0.9 microns, 0.5 to 1 microns, 0.5 to 1.1 microns, 0.5 to 1.2 microns, 0.5 to 1.3 microns, 0.5 to 1.4 microns, 0.5 to 1.6 microns, 0.5 to 1.7 microns, 0.5 to 1.8 microns, 0.5 to 1.9 microns, 0.5 to 2 microns, 0.5 to 2.1 microns, 0.5 to 2.2 microns, 0.5 to 2.3 microns, 0.5 to 2.4 microns, 0.5 to 2.5 microns, 0.5 to 2.6 microns, 0.5 to 2.7 microns, 0.5 to 2.8 microns, 0.5 to 2.9 microns, 0.5 to 3 microns, 0.5 to 3.1 microns, 0.5 to 3.2 microns, 0.5 to 3.3 microns, 0.5 to 3.4 microns, Or 0.5 to 3.5 microns. In some embodiments, the particle size of the extremely dry mist is about 0.5 to 3 microns.

One aspect of this application discloses the use of a hand-held spot spray device, which can be used to purify small enclosures by using an extremely dry mist containing ionized hydrogen peroxide. The handheld device includes a stylized clock and provides air pressure control and fluid flow control by using one or more potentiometers. The stylized clock provides the ability to automatically purify and circulate in the small enclosure. The purification cycle controlled by the programmed clock may include, for example, a cycle of spraying extremely dry mist for 30 seconds, stopping spraying for 10 seconds, and then restarting spraying for 30 seconds, and repeating this cycle for a fixed time period. The programmed clock can be manually set by the user or remotely controlled by the user or a computer processor with a pre-programmed purification cycle, which is transmitted to the equipment for deployment. In some implementations, purifying the space (including the small enclosure) contaminated by, for example, SARS-CoV-2 includes the following steps: input the input parameters of the small enclosure into the processing unit, wherein the processing unit is programmed Determine the fluid characteristics of the cleaning fluid in the purification equipment based on the input parameters of the small enclosure space, and start the purification cycle of the purification equipment. The purification cycle includes the following steps: providing a container of the cleaning fluid; setting the fluid characteristics of the determined cleaning fluid; Generates a very dry mist of a clean fluid containing ionized hydrogen peroxide, wherein the generated very dry mist is applied to purify a substantially small enclosure, and wherein the determined fluid characteristics of the clean fluid are implemented by controlling an air valve The setting. The cleaning fluid can be supplemented with amphiphiles (such as surfactants) to enhance virus purification. In some embodiments, the user can manually control the purification cycle by manually operating the control knob of the device (which controls the spray of the extremely dry mist).

In some embodiments, the device will have a computer processor that can calculate the appropriate settings (for example, flow rate, air pressure, number and length of purification cycles) to produce extremely dry containing ionized hydrogen peroxide The very dry mist will effectively purify the small enclosure. In this implementation aspect, the user can manually input the parameters of the small enclosure into the device, or input them remotely via a wireless connection. The operation of the equipment can be fully automated, fully manually controlled, or semi-automatic (for example, using an automatically executed purification cycle based on parameters that have been manually entered).

Figure 16 shows an embodiment of the cleaning fluid source, especially the mist generator 142, which operates on two platforms. One platform can be a hand-held spot spray surface purification device, and the other platform can be a programmable automated environmental purification device designed for small enclosures. The hand-held spot spray function allows manual or automatic control of the purification action. Programmable automation allows the input of surrounding parameters for predictable and consistent operation in an optimal layout that matches the geometry of the purification enclosure.

Figure 17 shows an embodiment of the display of the stylized clock 143 of the fog generator 142 shown in Figure 16 that can be adjusted to control, for example. The voltage source in the purification equipment can be connected to an adjustable voltage divider, such as a potentiometer. The potentiometer may include a housing containing a resistance element and a contact sliding along the resistance element, two electrical terminals at two ends of the resistance element, and a mechanism for moving the sliding contact from one end to the other. The potentiometer used can be a circular slider potentiometer, a pad slider potentiometer, or any other suitable slider arrangement can be used. The potentiometer may include, for example, a resistance element made of graphite, plastic containing carbon particles, resistance wire, or a mixture of ceramic and metal.

The potentiometer can be controlled by the control unit to adjust the input of the voltage source circuit. The potentiometer may allow the user to control the air pressure and fluid flow rate of the cleaning fluid mist flowing through the tube 150. Although the reduced air pressure affects the size of the mist particles produced, the tube 150 can be modified into a funnel nozzle to compensate for this reduction. The lateral diameter of the tube can be gradually changed so that the spray of the purified fluid is adjusted by the tube 150 to generate the required mist/fog particle size.

The voltage source may be a battery or a circuit, which is used to provide a high voltage to the activation source for a sufficient time to activate the amount of clean fluid stored in the pressure vessel. As mentioned above, the tube 150 can be a nozzle of a pressure vessel or a funnel shape. As shown in Figure 16, the tube 150 can be attached to a handheld device 142 that operates from a source of cleaning fluid and has a plug-in or battery voltage source. The cleaning fluid source may be pressurized to drive the cleaning fluid through the tube 150, or an optional pump may be provided that forces the cleaning fluid through the mist generator 142 with greater force and out of the tube 150.

As shown in Figure 16, the purification device 142 can be mounted on a rotating base that allows better coverage of the area to be purified. The rotating base can be a 180-degree rotating base or a 360-degree rotating base. In some embodiments, the rotating base is an adjustable rotating base with a rotation range of 60 to 360 degrees. In some embodiments, the rotation system surrounds a single axis. In other embodiments, the rotation system revolves around multiple axes. In other embodiments, it rotates in all directions or is a completely spherical motion. In another embodiment, the knob 210 can be used to manually adjust the air pressure and fluid flow rate.

In a programmable device, the control unit can be programmed to control the potentiometer and the pump based on the desired fluid parameters. For example, in a very small enclosure, a drier fog is generated so that the fog can travel a shorter distance. This can be achieved by reducing the air pressure of the purification device sufficiently below the predetermined standard pressure, or reducing the standard fluid flow rate sufficiently below the predetermined standard flow rate. The standard air pressure input to the programmable control unit can be 25 to 50 pounds per square inch, and the input standard air pressure range can be appropriately modified as needed. In addition, the standard fluid flow rate input to the programmable control unit can be 25 to 50 ml/min, and the input standard fluid flow rate range can be appropriately modified as required.

In some embodiments, the air pressure of the purification device can be 5 to 25 psig, or in alternative embodiments, it can be 10 to 20 psig. In an example discussed in detail below, the air pressure of the purification equipment is 15 pounds per square inch. In addition, in some embodiments, the flow rate of the purification fluid may be 5 to 25 ml/min, or in alternative embodiments, it may be 10 to 15 ml/min. In an example discussed in detail below, the flow rate of the purification fluid is 10 ml/min.

In some embodiments, the spray pattern of the cleaning fluid can be set based on spray cycle parameters, such as the time period during spraying, the time period between two consecutive sprays, and the total number of sprays performed.

In some embodiments, the time period between two consecutive sprays can be 1 to 600 seconds, 1 to 300 seconds, 1 to 180 seconds, 1 to 150 seconds, 1 to 120 seconds, 1 to 90 seconds, 1 To 60 seconds, 1 to 45 seconds, 1 to 30 seconds, 1 to 15 seconds, 10 to 600 seconds, 10 to 300 seconds, 10 to 180 seconds, 10 to 150 seconds, 10 to 120 seconds, 10 to 90 seconds, 10 To 60 seconds, 10 to 45 seconds, 10 to 30 seconds, 30 to 600 seconds, 30 to 300 seconds, 30 to 180 seconds, 30 to 150 seconds, 30 to 120 seconds, 30 to 90 seconds, 30 to 60 seconds, 30 To 45 seconds, 60 to 600 seconds, 60 to 300 seconds, 60 to 180 seconds, 60 to 150 seconds, 60 to 120 seconds, 60 to 90 seconds, 90 to 600 seconds, 90 to 300 seconds, 90 to 180 seconds, 90 To 150 seconds, 90 to 120 seconds, 120 to 600 seconds, 120 to 300 seconds, 120 to 180 seconds, 120 to 150 seconds, 150 to 600 seconds, 150 to 300 seconds, 150 to 180 seconds, 180 to 600 seconds, 180 To 300 seconds, or 300 to 600 seconds. In an example discussed in detail below, the time interval between two consecutive sprays is 60 seconds. In addition, in some embodiments, the time period of the spraying period may be 10 to 1800 seconds, 10 to 1200 seconds, 10 to 900 seconds, 10 to 600 seconds, 10 to 300 seconds, 10 to 180 seconds, 10 to 150 Seconds, 10 to 120 seconds, 10 to 90 seconds, 10 to 60 seconds, 10 to 45 seconds, 10 to 30 seconds, 30 to 1800 seconds, 30 to 1200 seconds, 30 to 900 seconds, 30 to 600 seconds, 30 to 300 Seconds, 30 to 180 seconds, 30 to 150 seconds, 30 to 120 seconds, 30 to 90 seconds, 30 to 60 seconds, 30 to 45 seconds, 60 to 1800 seconds, 60 to 1200 seconds, 60 to 900 seconds, 60 to 600 Seconds, 60 to 300 seconds, 60 to 180 seconds, 60 to 150 seconds, 60 to 120 seconds, 60 to 90 seconds, 90 to 1800 seconds, 90 to 1200 seconds, 90 to 900 seconds, 90 to 600 seconds, 90 to 300 Seconds, 90 to 180 seconds, 90 to 150 seconds, 90 to 120 seconds, 120 to 1800 seconds, 120 to 1200 seconds, 120 to 900 seconds, 120 to 600 seconds, 120 to 300 seconds, 120 to 180 seconds, 120 to 150 Seconds, 150 to 1800 seconds, 150 to 1200 seconds, 150 to 900 seconds, 150 to 600 seconds, 150 to 300 seconds, 150 to 180 seconds, 180 to 1800 seconds, 180 to 1200 seconds, 180 to 900 seconds, 180 to 600 Seconds, 180 to 300 seconds, 300 to 1800 seconds, 300 to 1200 seconds, 300 to 900 seconds, 300 to 600 seconds, 600 to 1800 seconds, 600 to 1200 seconds, 600 to 900 seconds, 900 to 1800 seconds, 900 to 1200 Seconds or 1200 to 1800 seconds. In some cases, the spray period is 90 seconds and the spray interval is 60 seconds. In some embodiments, the injection cycle includes injection time and interruption time, and the complete purification process includes 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 injection cycles.

Compared with programmable devices, the handheld surface cleaning equipment can be manually operated by rotating the control knob on the handheld applicator to generate a very dry mist of ionized hydrogen peroxide. In one example, the fluid or air settings are not programmable, but are manually controlled by the user based on the user's assessment of the actual limitations of the small enclosure.

An embodiment of the handheld device 142 is used in combination with the small enclosure to achieve the purification of the inside of the small enclosure. The enclosure can be used as a chamber where the target object is purified. The target object can be stationary, or it can move through the enclosure on a conveyor. The small enclosure can be defined by various features relative to the device 142, such as: the size of the enclosure, the relative position of the device 142 from the boundary of the enclosure, the temperature/pressure/humidity in the enclosure, or the enclosure considered to be relevant Any other characteristics of the space. In addition, when the target object moves within the small enclosure, the initial position of the object, its relative speed, and its moving direction with respect to the device 142 can be measured for subsequent input. When the device 142 rotates around a fixed position in the enclosure, the rotation speed can be determined and used as input for processing by the computer processor.

The device 142 can be integrated into a system for purification. The input of the small enclosure relative to the device 142 and any target object characteristics can be manually entered into the system, or can be measured by multiple sensors. The sensor can communicate with a computer processor (for example, a control unit programmed to control the device 142) in network communication. The control unit can control an adjustable potentiometer that adjusts parameters related to the purification cycle of the device 142.

In one example, ionized hydrogen peroxide mist is added to and mixed with another gas stream. The activated clean fluid mist is mixed with the airflow, and the mixed airflow contacts the small enclosure and/or the surface of the target object. Some parameters related to the performance of the purification device 142 may be the pressure of the gas mixed with the mist and the fluid flow rate of the fluid leaving the device 142. For example, the parameters can be adjusted by controlling the air valve 190 placed on the front of the device 142, and/or by changing the size and shape of the tube 150.

As shown in Figure 17, the fluid parameters of the purification equipment 142 can be monitored on the display of the device. The parameters can be adjusted remotely. In one embodiment, a wireless network connection can be implemented between the control unit and the device 142 to set the fluid parameters of the device 142. In some embodiments, the wireless connection includes, but is not limited to, radio frequency, infrared, wifi, Bluetooth, or any other suitable wireless communication method.

The adjustment of fluid parameters is particularly important in small enclosures. The mist generating device 142 allows the fluid flow rate and air pressure to be manipulated as needed to adapt to the unique settings required for very small spaces. For example, a very small enclosure requires that the allocated fog only travels far enough to reach the longest dimension of the enclosure, or to reach the target object. For example, fluid parameter adjustment can be done with air valve 190, and can be verified with a barometer also located in the front of the unit.

A common problem with traditional technology is that the mist particles produced by excessive air pressure drop are too large to obtain the required mist distribution. At the same time, a very small enclosing space usually requires a significant pressure drop. Certain implementation aspects of the present disclosure solve these opposite constraints of the purification system. That is, by programming the processor to control the potentiometer based on the input parameters of the small enclosing body, the user can adjust the fluid flow rate in synchronization with the air pressure. As a result, the air pressure is reduced while the fluid flow rate is reduced to keep the mist particles small in size, while limiting the distance that the spray can reach. In this way, the mist sprayed by the device 142 is kept within the boundary of the small enclosure without excessive humidity and dense mist. Therefore, the programmable balance between air pressure and fluid flow rate prevents saturation of the surface opposite to the mist applicator, increased moisture accumulation due to condensation, false negative verification results or increased ventilation time of the surrounding body.

In the alternative, if manually controlled, the device 142 can also generate all the confirmed benefits. That is, the handheld platform of the purification device 142 allows operation to generate ionized hydrogen peroxide mist by using the control knob on the handheld applicator. In some implementations, the device is designed to be used by a technician using a trigger on the device to control its use by adjusting the position of the trigger. In other implementation aspects, the operation of the device can be fully automated or semi-automated. The expected value obtained manually can be monitored on the device display.

The purification equipment/system can be expandable and configurable to be effective in any size or volume of space/room/chamber/container. Scalability can be achieved by the size of the equipment, by manually controlling the purified fluid, or by programming the air pressure of the equipment and the subsequent fluid flow rate as a function of input space/room/chamber/container parameters. Therefore, the size and volume of the device 142 can be selected according to the geometry of the enclosure and the position of the target object in the enclosure to optimize the purification performance.

In some embodiments, the micro purification device 142 further includes a control module that allows remote devices such as a tablet computer or a phone to control (for example, start and/or stop the device) and monitor the micro purification device. In other implementation aspects, the control module further controls data storage, transmission and printing. In some implementations, the control module allows remote services and connections, is used to record video or data, and is used to provide feedback to the user during or after use.

The following examples are only used for illustration, and should not be regarded as limiting aspects or implementation aspects of this application. Example 1

In the first test series, the same Serratia marcenscens culture was prepared by spreading on the filter paper. A sample was incubated in air at 30°C for 24 hours as a control. A significant growth of the bacterial culture was observed. The second sample was exposed to a 3 vol% hydrogen peroxide mist (unactivated) in the air at one atmosphere pressure for 60 seconds, and then incubated in the air at 30°C for 24 hours. A significant growth of the bacterial culture was observed. The third sample was exposed to 3 vol% hydrogen peroxide mist activated by a 10.5 kV AC arc in the air at one atmosphere pressure for 60 seconds, and then incubated in the air at 30°C under one atmosphere pressure for 24 hour. The sample showed no growth of the bacterial culture, and the bacterial culture was killed by treatment. After proving that the activation treatment made 3% hydrogen peroxide mist can prevent growth, the hydrogen peroxide mist of 1.5%, 0.75%, 0.3% and 0% (only "activated" water vapor) concentration was used to test another corresponding sample , Expose to air for 60 seconds at one atmosphere pressure and incubate as described. The samples in contact with 1.5% and 0.75% hydrogen peroxide mist showed no growth. The samples exposed to 0.3% hydrogen peroxide mist showed very slight growth. The samples exposed to the 0% hydrogen peroxide mist showed significant growth of the bacterial culture. Example 2

For the second and third test series, a pipeline simulation structure was established. The pipe simulation structure is a vertically oriented pipe with a diameter of about 10 inches and a length of 10 feet. The mist generator and the activator are installed at the top of the pipe, and a fan operating at an airflow of about 350 to 400 cubic feet per minute is installed at the bottom of the pipe to guide the gas down through the pipe. The test ports are located at 1 foot, 2 feet, 4 feet and 6 feet from the top of the pipe, and samples to be tested are inserted into each port.

In the second test series, each of the bacterial spore strips (each about 3/4 inch long and 1/4 inch wide) impregnated with about 10 ⁶ Bacillus stearothermophilus spores was placed in the pipeline simulation structure for each test Buzhong. After the test, the samples were incubated at 50°C for 7 days. In the first sample series, only air (without hydrogen peroxide) was flowed through the sample for 15 seconds. After incubation, significant growth of bacterial cultures was observed in all test ports. In the second sample series, a 6% by volume hydrogen peroxide mist was generated, but it was not activated, and it flowed through the sample for 15 seconds. As with the first test sample series, significant growth of the same bacterial culture was observed in all test ports. In the third sample series, the process was repeated, but activated by passing 6% of hydrogen peroxide mist through a 15 kV AC arc. No bacterial culture growth was observed in any test port. The results for Bacillus stearothermophilus are significant, because this bacterium is known to be resistant to growth control using conventional low percentage non-activated hydrogen peroxide treatment. Example 3

In the third test series, except for the bacterial strain Bacillus subtilis var. niger , the bacterial spore strips as described above were used. Bacillus subtilis var. Niger belongs to the same genus and is a recognized substitute for Bacillus anthracis that causes anthrax. Due to its similarity with Bacillus anthracis, the Bacillus subtilis variety Niger is used in laboratory tests to study the growth and control of anthrax without the risk of infection or transmission of anthrax. In the first sample series, only air (without hydrogen peroxide) was flowed through the sample for 15 seconds. Significant growth of bacterial cultures was observed from all ports after incubating the samples. In the second sample series, a 6% by volume hydrogen peroxide mist was generated, but it was not activated, and it flowed through the sample for 15 seconds. As with the first test sample series, significant growth of the same bacterial culture was observed in all ports. In the third sample series, the process was repeated, but 6% hydrogen peroxide mist was activated by a 15 kV AC arc. No bacterial culture growth was observed in any port. The test confirmed that the method controlled the growth of anthrax substitutes in the pipeline simulation structure. Example 4

In further tests, the ultrasonic cavitation of the cleaning fluid produced a low-pressure and low-air flow mist, resulting in excellent killing.

A 16 × 16 × 16 inch box was constructed for the test, in which the nozzle of the purification device penetrates the bottom of the box in the center of the bottom panel.

Place the 6-Log biological (Geobacillus stearothermophilus) and chemical (iodine H ₂ O ₂ ) indicators at the center of all vertical panels. Biological and chemical indicators are also placed on the bottom panel of the box, next to the nozzle.

Pour the activated mist into the box for one minute and let it stay for 5 minutes.

The biological indicator was then removed from the box and incubated for 7 days. After incubation, check the biological indicator and show that 6 logs of bacteria have been killed.

Although specific implementation aspects have been described in detail for the purpose of illustration, various modifications and enhancements can be made without departing from the spirit and scope of the application. Therefore, this application is not limited by the described implementation modes. Example 5

In the efficacy test, the purification equipment/system of this disclosure is tested against a variety of bacterial spores and gram-negative bacteria (including multiple drug-resistant organisms), gram-positive bacteria, molds and viruses. Using the procedure described in this disclosure, the log ¹⁰ reduction of organisms in the following table was determined: organism category Log reduction Bacillus atrophicus (a substitute for Bacillus anthracis) Bacterial spores ＞8.3 Geobacillus stearothermophilus Bacterial spores ＞6.3 Bacillus subtilis Bacterial spores ＞6.0 Clostridium difficile Bacterial spores ＞6.0 Escherichia coli Gram-negative bacteria ＞7.4 Pseudomonas aeruginosa Gram-negative bacteria ＞6.0 Serratia marcescens Gram-negative bacteria ＞6.0 Salmonella enteritidis Gram-negative bacteria ＞5.5 Staphylococcus aureus Gram-positive bacteria ＞7.4 Methicillin-resistant Staphylococcus aureus Gram-positive bacteria ＞5.9 Bacillus atrophicus vegetative cell Gram-positive bacteria ＞9.0 Aspergillus niger Mold ＞8.0 Aspergillus species Mold ＞7.0 Cladosporium species Mold ＞7.0 Penicillium species Mold ＞7.0 Stachybotrys chartarum Mold ＞7.0 Trichophyton mentagrophytes Mold ＞6.0 Human rhinovirus 16 (a substitute for human influenza virus) virus ＞6.8 Influenza A virus (H1N1) virus ＞10 Norovirus virus ＞6.4 Adenovirus virus ＞5.8

The results shown in the table indicate that the purification equipment/system of the present invention is an effective broad-spectrum surface and air disinfectant/purifier. It is effective against bacterial spores, gram-negative bacteria, gram-positive bacteria, multi-drug resistant organisms, molds and viruses. The purification equipment/system is effective for the mitigation and remediation of mold and the elimination of bacteria and viruses.

The purification cycle discussed in this article is about the conversion of hydrogen peroxide solution into ionized hydrogen peroxide after passing through an atmospheric cold plasma arc. Ionized hydrogen peroxide contains a high concentration of reactive oxygen species mainly composed of hydroxide radicals. Active oxygen substances destroy pathogenic organisms by oxidizing proteins, carbohydrates and lipids. This leads to cell destruction and/or dysfunction, and allows disinfection/purification in the target area (including large spaces).

In some embodiments when applied directly to the surface, the particle size of ionized hydrogen peroxide is 0.5 to 3 microns, the flow rate is 50 ml/min, the dosage is 1 ml/square foot, and the application time is per square foot. 5 seconds above the treatment area with a contact time of 7 minutes to disinfect/purify the high touch surface. In a specific embodiment, the solution used is formulated to be free of silver, chlorine, and peracetic acid, which maximizes compatibility with rubber, metal, and other materials on the surface. In other implementation aspects, for a room exceeding 3,500 cubic feet, an effective whole room treatment can be achieved within 45 minutes. In this implementation aspect, the flow rate can be 25 ml/min/applicator used (depending on the size of the room), and the dose application can be 0.5 ml/cubic foot. Once the hydrogen peroxide is below 0.2 ppm, the room can be safely entered. The treatment time, dosage, residence time, etc. can be changed to suit the purification goals required by the user. Example 6

In an embodiment where it is applied directly to the surface, a small enclosure space is purified. The size of the small container used for this treatment is 12" × 12" × 12". One of the purposes of this embodiment is to keep the particle size of the purification mist small enough (for example, 0.5 to 3 microns) to avoid excessive concentration The fog caused moisture accumulation and increased ventilation time, resulting in false negative verification results. In this example, four injections were performed, 60 seconds between each two consecutive injections, and a pulse program was run for about 90% during each injection Seconds. Taking into account the reduction in container size, the air pressure in the purification equipment is sufficiently lower than the standard pressure range (for example, 25 to 50 psi) and reduced to 15 psi. In order to prevent the pressure drop from producing undesirable large sizes For mist particles, the fluid flow rate is also sufficiently lower than the standard range flow rate (for example, 25 to 50 ml/min) and reduced to 10 to 12 ml/min. The treatment time, dosage, residence time, etc. can be changed to suit the purification goals required by the user The extremely dry fog unexpectedly increases the killing rate of pathogens on the surface of the small enclosing body.

This application claims the priority of the U.S. Application No. 16/391,812 filed on April 23, 2019. The entire content of the above application is hereby for reference.

The above description is intended to teach those skilled in the art how to implement this application, and is not intended to describe in detail all the obvious modifications and changes that will become apparent to the skilled person by reading the specification. However, all obvious modifications and changes are included in the scope of this application. Unless the context clearly indicates to the contrary, the scope of the patent application is intended to cover any components and steps of the order that effectively meet the expected goals.

20, 22, 24, 26, 28: steps 38: Purification equipment 40: Clean fluid source 42: fog generator 44, 48: Clean fluid mist 46, 46a, 46b: activator 50, 150: tube 52: voltage source 54: Pump 56: Encirclement 58: Object 60: Airflow/gas 62: pipe 64: filter 66: face mask 70: activation device 72: Fog delivery unit 74: Top chamber part/channel 76: Plasma activator/electrode 78: Ultrasonic wafer/ultrasonic cavitation device/ultrasonic cavitation device 80: Cleaning fluid 82: sprayer 84: control device 86: Control instruction 88: Feedback 92, 96: Two-way communication 94: Information 98: Sensor 100: high pressure activator 102: Diode/Capacitor 142: Mist Generator/Handheld Equipment/Purification Equipment 143: Stylized Clock 190: Air valve 210: Knob

Figure 1 is a block diagram of the general method of denaturing biochemical reagents using activated clean fluid mist.

Figure 2 is a schematic diagram of a first embodiment of a device for denaturing biological reagents, in which the position of the activator is close to the mist generator.

Figure 3 is a schematic diagram of a second embodiment of the device for denaturing biological reagents, in which the position of the activator is far from the mist generator.

Figure 4 is a schematic diagram of a third embodiment of a device for denaturing biological reagents, which has both near and far activators.

Figure 5 shows the flow purification equipment.

Figure 6 shows the chamber-based purification equipment.

Figure 7 shows the purification equipment used to clean the room.

Figure 8 shows the purification equipment for heating, ventilation and air conditioning duct systems.

Figure 9 shows the air purification equipment used for human breathing.

FIG. 10A shows the configuration of equipment components, in which the cleaning fluid source 40 and the mist generator 42 are connected by an activation device 70, which has an adjustable rotation range of up to 360 degrees. Figure 10B shows the configuration of the equipment components, in which the cleaning fluid source 40 is connected to the mist generator 42, and the mist generator 42 is connected to the mist delivery unit 72 through the activation device 70. The activation device 70 has an adjustable rotation range of up to 360 degrees . Figure 10C shows the configuration of the equipment components. The mist generator 42 is mounted on the activation device 70, which has an adjustable rotation range of up to 360 degrees. Figure 10D shows another configuration of the equipment components, in which the mist generator 42 is fed into the mist delivery unit 72, which is installed on the activation device 70, which has an adjustable rotation range of up to 360 degrees.

FIG. 11A depicts an implementation aspect in which at least the mist generator 42 and the voltage source 52 are contained in a portable housing. The mist generator is functionally connected to the mist delivery unit 72, and the mist delivery unit 72 can be mounted on the housing or attached to a remote unit. Figure 11B depicts the mist generator 42 and the voltage source 52 contained in a portable container, in which the entire unit can be hand-held, installed on another device, or held by another machine or robot or installed on another machine or On the robot. Figure 11C depicts an exemplary embodiment in which the mist generator 42 and the voltage source 52 are contained in a wearable container such as a backpack.

Figure 12A shows a purification device, which contains an ultrasonic wafer 78 or an ultrasonic sprayer as a mist generator. Figure 12B shows a system in which a mobile/wireless/remote control device 84 is functionally connected to the purification equipment of the present disclosure, such as a sprayer 82. Figure 12C shows an implementation aspect of the system, where the system includes a plurality of purification devices, such as sprayers, which are controlled by the control device 84 and further communicate between the sprayers 82 by wired or wireless means. The information from each sprayer 82 can be fed back to the control device 84 as a whole or individually. For example, the doses emitted by two different nebulizers 82 can be started or completed at different times, and the data can be reported independently.

Figures 13A to 13B show a similar system with a single (Figure 13A) or multiple (Figure 13B) mist generators 42 controlled by a control device 84, which further provides information about the area to an external source Or surface treatment data 94.

FIG. 14 shows a system in which the mist generator 42, the cleaning fluid source 40, and the mist delivery unit 72 are further connected to the sensor 98.

Figure 15 shows an exemplary rectifier for the formation of free radicals, including a voltage source 52 and at least one diode/capacitor 102 connected to a plasma activator 76.

Figure 16 depicts an implementation aspect of the mist generator 142. The mist generator 142 can be manually operated as a handheld device and can be programmed for automatic operation.

Figure 17 depicts the implementation of the display of the stylized clock 143, which adjusts the fluid characteristics of the fluid applied by the mist generator device.

Throughout the drawings, unless otherwise specified, the same reference numerals and characters are used to indicate similar features, elements, components, or parts of the illustrated embodiments. In addition, although the present disclosure will now be described in detail with reference to the accompanying drawings, it is completed in conjunction with illustrative implementations and is not limited by the specific implementations shown in the accompanying drawings and the scope of the attached patent application.

no

20, 22, 24, 26, 28: steps

Claims (20)

A method for purifying enclosures, including the following steps: Input the input parameters of the small enclosure into the processing unit, wherein the processing unit is programmed to determine the fluid characteristics of the cleaning fluid in the purification equipment based on the input parameters of the small enclosure space, Start the purification cycle of the purification equipment, wherein the purification cycle includes the following steps: providing a reservoir of the cleaning fluid; setting the determined fluid characteristics of the cleaning fluid; generating a very dry mist of the cleaning fluid containing ionized hydrogen peroxide, The extremely dry mist is applied to purify the substantially small surrounding body; And the setting of the determined fluid characteristics of the cleaning fluid is performed by controlling the air valve. The method according to claim 1, further comprising manually operating the purification equipment. The method according to claim 2, wherein the purification device is hand-held and manually operated. The method according to claim 1, wherein the input parameters of the small enclosure include: the size of the small enclosure space, the position of the purification equipment relative to the boundary of the small enclosure space, and the temperature of the small enclosure space , Pressure and humidity. The method according to claim 1, wherein the set fluid characteristics of the cleaning fluid include air pressure and fluid flow rate. The method according to claim 1, wherein the small enclosure system is contaminated with one or more selected from the group consisting of norovirus, adenovirus, SARS-CoV-2 and influenza A virus. The method according to claim 6, wherein the air valve is controlled by programming the processing unit to control the potentiometer. The method according to claim 1, wherein the fluid characteristics of the determined cleaning fluid are adjusted by the size and shape of the tube at the outlet of the cleaning fluid outside the purification device. The method according to claim 1, wherein the extremely dry mist contains particles having a diameter of 0.5 to 3 microns. The method according to claim 5, wherein the fluid characteristics of the cleaning fluid are set by reducing the air pressure and the fluid flow rate to lower than a predetermined standard air pressure and a predetermined standard fluid flow rate, respectively. The method described in claim 1, further including: The input parameters of the target area are input to the processing unit, wherein the processing unit is further programmed to determine the fluid characteristics of the cleaning fluid in the purification device based on the input parameters of the target area. The method according to claim 11, wherein the extremely dry mist comprises particles having a diameter of 0.5 to 3 microns. The method according to claim 1, wherein the input parameters of the small enclosure are manually input. The method according to claim 1, wherein the input parameters of the small enclosing body are measured by a plurality of sensors that communicate with the processing unit through a network. The method according to claim 1, wherein the processing unit and the purification device are in wireless communication. A system for purifying small enclosing bodies, comprising a purification device and a computer processor, wherein the computer processor communicates with the purification device through a network, Among them, input the input parameters of the small enclosure space into the computer processor, Wherein, the computer processor is programmed to determine the fluid characteristics of the cleaning fluid in the purification equipment based on the input parameters of the small enclosure space, Wherein, the computer processor is further programmed to start the purification cycle of the purification equipment, and the purification cycle includes the following steps: providing a reservoir of the cleaning fluid; setting the determined fluid characteristics of the cleaning fluid; The extremely dry mist of the clean fluid, Among them, the extremely dry mist is applied to purify the substantially small surrounding body space, And, the setting of the determined fluid characteristics of the cleaning fluid is performed by controlling the air valve. The system according to claim 16, wherein the purification device is manually operated. The system according to claim 17, wherein the purification device is hand-held and manually operated. The system according to claim 16, wherein the input parameters of the small enclosure include: the size of the small enclosure, the position of the purification equipment relative to the boundary of the small enclosure, and the temperature and pressure of the small enclosure space And humidity. The system according to claim 16, wherein the set fluid characteristics of the cleaning fluid include air pressure and fluid flow rate.

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