TW202038858A - Parkinson disease diagnosis system - Google Patents

Abstract

The invention discloses a Parkinson disease diagnosis system. The system is characterized by comprising a limb information collection module comprising reference point indicating units fixed to the limbs of a patient and an information collection unit used for acquiring position information of the reference point indicating units, a control analysis module and a real-time response module used for conducting stimulation or treatment actions on the patient according to a control command output by the control analysis module; Parkinson disease diagnosis analysis software is preset in the control analysis module, and through the Parkinson disease diagnosis analysis software, the current displacement information of the limbs is analyzed and processed, or contrastive analysis is conducted on displacement information of a plurality of time periods. The Parkinson disease diagnosis system can accurately and efficiently complete Parkinson disease diagnosis and assists medical personnel in better treating the patient with the Parkinson disease.

Description

Parkinson Diagnostic System

The invention relates to a diagnosis system, in particular to a Parkinson's diagnosis system that quantifies the course of the disease, completes the diagnosis of Parkinson's disease with relative accuracy and high efficiency, and assists medical personnel in making treatment judgments for patients with Parkinson's disease.

Parkinson’s disease (PD.) is no longer just a common chronic degenerative neurodegenerative disease in middle-aged and elderly people. The “immortal cancer” Parkinson’s disease is also gradually becoming younger and younger. The cause is the brain The symptoms of dopaminergic neurons in the substantia nigra striatum, which cause a significant decrease in the content of dopamine in the striatum. The main manifestations of Parkinson's disease can include physical symptoms such as hyperactivity, postural balance instability, tremor, and muscle stiffness, as well as physiological symptoms such as hyposmia, sleep disturbance, and constipation. In 2015, a total of 2.7 million people with Parkinson’s disease in China were counted. The prevalence increased with age. It was also promoted to the younger population due to dietary culture and environmental pollution. This will bring huge benefits to families and society. Economic burden.

At present, there are many patients, few doctors, long diagnosis, early detection, early diagnosis, and early treatment. Early diagnosis and course analysis of Parkinson's disease are not easy. In particular, the evaluation method of Parkinson’s disease motor symptoms is usually the Parkinson’s disease rating scale UPDRS and MDS-UPDRS to evaluate the patient’s condition. Each doctor conducts manual observation and completes the specified actions for the patient. The fluency is scored and comprehensive disease assessment. A complete set of processes It is time-consuming and labor-intensive, increasing the burden on doctors, and due to different mental conditions of doctors, there are errors, even if the judgments made by the same doctor at different times are not necessarily the same, the diagnosis result is subjectively affected and affects the entire diagnosis data process, so , The inventor proposed a new solution to solve this problem.

In view of the above-mentioned shortcomings of conventional use, the inventor researched and improved ways to address the above-mentioned shortcomings, and finally came to the present invention.

The main purpose of the present invention is to provide a Parkinson's diagnosis system that quantifies the course of the disease.

The secondary purpose of the present invention is to provide a relatively accurate and efficient Parkinson's disease diagnosis system.

Another object of the present invention is to provide a Parkinson's diagnosis system that assists medical personnel in making treatment judgments for patients with Parkinson's disease.

In order to achieve the above objectives and effects, the technical means adopted by the present invention include: a displacement information collection module, a control analysis module and a real-time action module, among which:

The displacement information acquisition module includes a positioning unit and an information acquisition module. The information acquisition module senses the position of the positioning unit to acquire displacement information and transmit it to the outside;

The control analysis module presets Parkinson’s disease diagnostic analysis software, which is electrically connected to the aforementioned information collection module, receives displacement information per unit time, or compares and analyzes displacement information in multiple time intervals, calculates, processes and generates External transmission of a diagnosis information and a control signal;

The real-time action module is electrically connected to the aforementioned control analysis module, receives and generates corresponding actions according to the control signal.

In this way, the positioning unit is worn at the designated position of the patient's limbs and enters the collection range of the information collection module, so that the information collection module can collect the positioning unit, that is, the displacement information of the patient's limbs; the displacement information collected by the information collection module is returned It is fed to the control analysis module and processed by Parkinson’s disease diagnostic analysis software to quantify the patient’s disease course for medical staff to make a diagnosis reference; since the diagnosis process at this time no longer relies on manual labor, it can be effective Eliminate the interference caused by subjective factors, so as to improve the accuracy and efficiency of Parkinson's disease diagnosis; at the same time, because the control analysis module is connected with the real-time action module, the medical staff can also control it to treat the patient at this time Action, so that the use effect is better; and because there is a displacement information collection module to collect the patient’s current course of disease in real time, medical staff can clearly understand which body parts and the degree of treatment are more effective for the patient based on the real-time dynamic diagnosis results. It is effective (different patients have different symptoms and different treatment methods), so the use effect of the present invention is better.

According to the above structure, the positioning unit includes, but is not limited to, a discriminator with a distinctive mark or an optical discriminator for optical recognition.

According to the above structure, the information collection module includes at least one or more camera units.

According to the above structure, the mobile information collection module includes a fixed positioning unit and a wearing fixing mechanism for wearing to the limbs, and the wearing fixing mechanism includes, but is not limited to, finger cots, Velcro, adhesive tape, elastic mesh cover or Wear the item to the structure of the limb.

According to the above structure, the displacement information collection module includes a motion collection module that is fixed to the wearable fixing mechanism and collects three-dimensional vectors. The motion collection module includes but is not limited to a gyroscope, an angle sensor, a speed sensor, or A sensor used to generate three-dimensional vector changes.

According to the above structure, the real-time action module includes at least one or more Electrode elements capable of releasing micro currents, or at least one or more phototherapy elements capable of releasing light stimulation.

According to the above structure, the control analysis module is electrically connected to a remote communication module, and the remote communication module includes but is not limited to wired transmission or wireless transmission.

In order to obtain a more detailed understanding of the above-mentioned purposes, effects and features of the present invention, the descriptions are as follows according to the drawings:

1‧‧‧Displacement information collection module

11‧‧‧Positioning unit

111‧‧‧Recognizer

112‧‧‧Optical Recognizer

12‧‧‧Information Collection Module

121‧‧‧Camera unit

13‧‧‧Motion acquisition module

14‧‧‧Wearing fixing mechanism

141‧‧‧Micro control module

142‧‧‧Microprocessor

143‧‧‧A/D converter

2‧‧‧Control Analysis Module

3‧‧‧Real-time action module

31‧‧‧Electrode element

32‧‧‧Light therapy element

33‧‧‧Microcontroller

331‧‧‧Single chip

4‧‧‧Remote communication module

Figure 1 is a block diagram of a preferred embodiment of the present invention.

Figure 2 is a second block diagram of the preferred embodiment of the present invention.

Please refer to all the drawings. It can be seen that the structure of the present invention mainly includes: a displacement information collection module 1, a control analysis module 2, a real-time action module 3, and a remote communication module 4. Among them:

The displacement information collection module 1 includes a positioning unit 11, an information collection module 12, a motion collection module 13 and a wearing fixing mechanism 14, wherein:

The positioning unit 11 is worn on the limb of the patient, and includes, but is not limited to, a discriminator 111 with a distinguishing mark, such as a sheet/block coated with a high-reflective coating, or an optical discriminator 112 for optical identification. , Such as infrared emitters, sheets/blocks coated with luminescent paint, luminescent crystals, etc.

The information collection module 12 senses the position of the aforementioned positioning unit 11 to obtain displacement information and transmits it to the outside. In a preferred embodiment, the information collection module 12 includes at least one or more camera units 121. Optional CCD camera composition, when used, To ensure that the corresponding displacement information can be obtained efficiently and accurately, multiple camera units 121 can be used together, and the horizons of view can be overlapped with each other.

The motion collection module 13 is used to collect the three-dimensional vector of the patient, including but not limited to a gyroscope, an angle sensor, a speed sensor, or a sensor for generating a three-dimensional vector change. The motion collection module 13 feeds back to the following description The three-dimensional vector information of the control analysis module 2 can be used in conjunction with the aforementioned displacement information, so that the medical staff can analyze the tremor of the patient in each posture, so that the diagnosis effect is better.

The wearing fixing mechanism 14 fixes the positioning unit 11 to a designated position on the patient's limbs, which includes but is not limited to finger cots, Velcro, adhesive tape, elastic nets, or structures for wearing articles to the limbs And, the wearable fixing mechanism 14 includes a microcontroller 141, which includes a microprocessor 142 and an A/D converter 143, and is electrically connected to the motion acquisition module 13.

The control analysis module 2 is preset with Parkinson’s disease diagnostic analysis software, which is electrically connected to the aforementioned information collection module 12 to receive displacement information, or compare and analyze the displacement information calculation processing of multiple time periods and generate a diagnostic information And a control signal for external transmission; in a preferred embodiment, the control analysis module 2 can select a computer, which is preset with a Parkinson’s disease diagnostic analysis software program; the Parkinson’s disease analysis software is based on Parkinson’s disease assessment In addition to analyzing and processing the aforementioned displacement information and three-dimensional vector information to obtain the displacement of each positioning unit 11 (for example: X, Y, Z axis), the scales UPDRS and MDS-UPDRS settings also have the following functions and functions:

A. Intercept a unit time (for example, 1 minute, 2 minutes, 3 minutes, etc.), and calculate the vibration frequency of the positioning unit 11 in the unit time to obtain the patient's tremor frequency;

B. Combine time parameters to generate monitoring dynamic curves for long-term observation, etc.;

C. Calculate the vibration amplitude of the positioning unit 11 according to the dynamic curve to obtain the tremor intensity of the patient;

D. Calculate the time consumption of each vibration cycle of the positioning unit 11 per unit time, or calculate the area of each waveform of the dynamic curve, to obtain information about the speed of the patient’s tremor, for example, considering that the patient’s Parkinson’s disease has limb stiffness, and there are thoughts Issues that have taken a step, but have not actually taken it;

E. Compare the data information of multiple groups of A-D, diagnose the tremor of patients at different time periods (before and after treatment), and get treatment evaluation.

The real-time action module 3 is electrically connected to the aforementioned control analysis module 2 and receives and generates corresponding actions according to the control signal. It includes a plurality of electrode elements 31 capable of releasing micro currents, or optical elements 32 capable of light stimulation. The electrode element 31 can choose an electrode needle or an electrode sheet, and the phototherapy element 32 can choose a UV phototherapy lamp or a laser transmitter; the real-time action module 3 can be attached to the user’s limbs through glue, suction cups, etc., and can be further used by medical care The personnel are fixed on each acupuncture point of the user. It should be noted that a plurality of electrode elements 31 are assembled to one or more microcontrollers 33 through wires. The microcontroller 33 further includes: a single chip 331 electrically connected to the aforementioned control analysis module 2 and according to the control The signal is used for treatment control.

The remote communication module 4 is electrically connected to the control analysis module 2, which includes but is not limited to wired transmission or wireless transmission. In a preferred embodiment, when the control analysis module 2 is a computer, the remote communication module Group 4 can be a wireless network card, a WIFI module or a Bluetooth module. At this time, the medical staff can diagnose and treat the patient remotely.

In this way, the patient wears the wearing fixing mechanism 14 fixed with the positioning unit 11 at the designated position of the limb. The wearing fixing mechanism 14 takes the finger cuff as an example. At this time, the positioning unit 11 can be fixed to the outside of the finger cuff by bonding. The patient enters the field of vision of the information collection module 12, and roots Stop or move according to the doctor's order; at this time, the information collection module 12 uses the camera unit 121 as an example to track and collect the video image of the positioning unit 11, and output it as displacement information to the control analysis module 2 described later, so that the control analysis module 2 can receive it After processing the displacement information, quantify the patient’s illness and provide a reference for the medical staff’s diagnosis; because the information collection module 12 collects the patient’s current course of disease in real time, after the control analysis module 2 controls the implementation of the real-time action module 3, the medical care The personnel can clearly understand which body parts and the degree of treatment are more effective for the patient based on the real-time dynamic diagnosis result (different patients have different symptoms and different treatment methods), so that the application effect of the present invention is better.

In addition to the above-mentioned effects, the present invention can also provide patients with intuitive diagnosis and evaluation through real-time collection of feedback, so that patients can understand their own state, and patients can understand the effects of treatment; at the same time, early detection and early diagnosis and treatment can be performed. Delaying the course of Parkinson's disease and controlling the symptoms of the disease can greatly help.

In summary, the present invention has the following technical features and benefits:

1. After the patient fixes the positioning unit 11 on the limb and enters the collection range of the displacement information collection module 1, the displacement information collection module 1 can collect the displacement information of the positioning unit 11 (the patient's limbs moves) and give feedback To the control analysis module 2, the control analysis module 2 makes a diagnosis of the patient’s Parkinson’s disease course based on the displacement information; the above diagnosis process no longer relies on manual labor, effectively eliminating the interference caused by subjective factors, thereby improving Parkinson’s disease The accuracy and efficiency of the diagnosis;

At the same time, because the limb information acquisition method of the present invention is to actively wear a reference indicator point (ie positioning unit 11) on the limb for the information collection module 12 to sense, it has the following advantages:

1-1. Because there is positioning unit 11 as a clear reference or as a base point, this Compared with the existing part of the motion information collection method, Ming’s analysis system does not need to re-analyze the contour of the target every time and calculate the base point position of the center point of the limb as the basis for subsequent displacement information calculation, so even if the patient’s limb is tremor at the beginning , The difficulty of data processing is relatively low, which greatly reduces the difficulty and cost of the present invention, and can effectively improve the efficiency and accuracy of diagnosis;

1-2. Since the present invention can use the positioning unit 11 as the base point of the limb displacement information, medical staff can manually fix the positioning unit 11 to the position of the limb to be tested according to needs, and complete the test point selection, thereby facilitating the completion of the medical staff Diagnostic work

1-3. Since the present invention can use the positioning unit 11 as a reference point for limb displacement information, medical personnel only need to record each displacement to a fixed position at a fixed point, and then according to needs, in the time period before and after treatment, respectively Fix it at the corresponding position on the limbs to form multiple sets of comparative data in the test, which is convenient for medical staff to diagnose and verify the treatment effect.

2. The control analysis module 2 is connected with the real-time action module 3, which can realize the treatment of the patient, and can judge the current treatment effect based on the diagnosis result of the real-time feedback.

3. The control analysis module 2 is connected to the remote communication module 4, so that when necessary, medical personnel can diagnose and treat patients remotely through the present invention, so that the use effect of the present invention is better.

The Parkinson’s diagnostic system of the present invention is indeed a novel and progressive invention. An application for a patent for invention was filed in accordance with the law; however, the content of the above description is only a description of the preferred embodiments of the present invention. Any changes, modifications, alterations or equivalent replacements extended by the scope shall also fall within the scope of the patent application of the present invention.

1‧‧‧Displacement information collection module

11‧‧‧Positioning unit

12‧‧‧Information Collection Module

13‧‧‧Motion acquisition module

2‧‧‧Control Analysis Module

3‧‧‧Real-time action module

4‧‧‧Remote communication module

Claims (7)

A Parkinson's diagnosis system, which at least includes: A displacement information collection module, which includes: A positioning unit; An information collection module, which senses the position of the aforementioned positioning unit to obtain a displacement information and transmits it to the outside; A control analysis module, preset Parkinson’s disease diagnostic analysis software, which is electrically connected to the aforementioned information collection module, receives displacement information, or compares and analyzes the displacement information calculation processing of multiple time periods and generates a diagnostic information and a External transmission of control signals; and, A real-time action module, electrically connected to the aforementioned control analysis module, receives and generates corresponding actions according to the control signal; In this way, the positioning unit is fixed at the designated position of the limb, and the information collection module senses the displacement information of the positioning unit, that is, the displacement state of the limb, and feeds it back to the control analysis module to achieve a quantified disease course situation, and use the time action module to perform corresponding The structure of real-time actions. For the Parkinson's diagnosis system described in item 1 of the scope of patent application, the positioning unit includes, but is not limited to, a discriminator with distinguishing marks or an optical discriminator for optical identification. For the Parkinson's diagnosis system described in the first item of the patent application, the information collection module includes at least one or more camera units. For example, the Parkinson's diagnostic system described in item 1 of the scope of patent application, wherein the mobile information collection module includes a fixed positioning unit and a wearable fixing mechanism for wearing to the limbs, and the wearable fixing mechanism includes but not limited to finger cots, magic Stickers, adhesive sheets, elastic nets or structures used to wear items to the limbs. For example, the Parkinson's diagnosis system described in the third scope of the patent application, wherein the displacement information acquisition module includes a motion acquisition module that is fixed to the wearable fixing mechanism and collects three-dimensional vectors, and the motion acquisition module includes but is not limited to a gyroscope, Angle sensor, speed sensor or sensor used to generate three-dimensional vector changes. As described in the first item of the scope of patent application, the Parkinson's diagnosis system, wherein the real-time action module includes at least one or more electrode elements capable of releasing micro-current, or at least one or more phototherapy elements capable of releasing light stimulation. For example, in the Parkinson's diagnosis system described in the first item of the patent application, the control analysis module is electrically connected to a remote communication module, and the remote communication module includes but is not limited to wired transmission or wireless transmission.

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