TW202027731A - Capsule - Google Patents

Abstract

The purpose of the present invention is to provide a novel means capable of suppressing insolubilization of a coating that includes gelatin. Provided is a capsule characterized in that an ingredient that comprises at least one selected from the group consisting of peppermint oil, parsley seed oil, and menthone oil is contained in a coating that comprises at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin.

Description

Capsules

The present invention relates to a capsule.

Gelatin is non-toxic to the human body and inexpensive, and has excellent gel forming ability and viscosity increasing properties. Therefore, gelatin is widely used as a component of capsules in the fields of medicine or food, among which gelatin derived from cattle is widely used as a component of capsules.

However, when gelatin is used as the film of the capsule, the solubility of the film tends to decrease over time due to a crosslinking reaction with the contents filled in the capsule. Such a decrease in solubility leads to insolubilization of the film, and for example, causes problems such as inability to properly release the active ingredient. Therefore, in the capsule, the insolubilization of the film causes serious problems such as quality degradation.

Heretofore, as a method of suppressing insolubilization of a film, for example, a method is known in which inositol phosphate is formulated in gelatin to prepare a composition for a film, and this is used as a film of a capsule (Patent Document 1). Although this method is known in the past, it is important to provide a new method that can suppress the insolubilization of the film. [Prior Art Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. 2006-328038

[The problem to be solved by the invention]

The object of the present invention is to provide a new method that can suppress the insolubilization of a film containing gelatin. [Means to solve the problem]

The inventors of the present invention conducted diligent studies in view of the above-mentioned problems, and found that they are combined with peppermint oil, parsley seed oil or menthone oil and bovine-derived gelatin. Compared with the combined use, the insolubilization of gelatin can be effectively suppressed when the above component is used in combination with gelatin derived from pig or fish. Based on these findings and further repeated studies, the present invention was completed as a result, as described below.

Item 1. A capsule, characterized in that: a skin film contains a content which contains at least one selected from the group consisting of porcine-derived gelatin and fish-derived gelatin, the content The substance contains at least one selected from the group consisting of peppermint oil, caraway oil and menthone oil. Item 2. The capsule according to Item 1, wherein the content further contains triglyceride, and the content contains 28 parts by mass or less of peppermint oil with respect to 100 parts by mass of the triglyceride. Item 3. The capsule according to item 1 or 2, wherein the content further contains triglyceride, and the content contains 28 parts by mass or less of caraway relative to 100 parts by mass of the triglyceride oil. Item 4. The capsule according to any one of items 1 to 3, wherein the content further contains triglyceride, and the content contains 28 parts by mass or less with respect to 100 parts by mass of the triglyceride Menthone oil. Item 5. The capsule according to any one of Items 1 to 4, which is a soft capsule. Item 6. A method for inhibiting insolubilization of a film, characterized in that: a capsule having a content and a film encapsulating the content contains one selected from peppermint oil, caraway oil, and menthone oil At least one content in the group is combined with a film containing at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin. [Effects of the invention]

According to the capsule or method of the present invention, the insolubilization of the film containing at least one selected from the group consisting of porcine-derived gelatin and fish-derived gelatin can be suppressed.

The present invention provides a capsule, which is characterized in that at least one content selected from the group consisting of peppermint oil, caraway oil, and menthone oil is contained in a film, and the film contains At least one of the group consisting of porcine-derived gelatin and fish-derived gelatin.

Contents In the capsule of the present invention, the content contains at least one selected from the group consisting of peppermint oil, caraway oil and menthone oil.

Peppermint oil is an essential oil obtained by refining the aerial part of peppermint by steam distillation, and is also known as CAS No. 8006-90-4. Peppermint oil is commercially available, for example, as peppermint white oil (manufactured by Nagaoka Industrial Co., Ltd.), peppermint oil (manufactured by Ogawa Fragrance Co., Ltd.) and the like.

The content of peppermint oil in the content is not limited, and examples thereof are preferably 0.2% by mass to 22% by mass, more preferably 0.5% by mass to 20% by mass, and particularly preferably 1% by mass to 10% by mass.

Caraway oil is an essential oil obtained from the seeds of parsley, and is also known as CAS No. 8000-68-8. Parsley oil is commercially available, for example, it is marketed as parsley oil (manufactured by Xiangrong Industrial Co., Ltd.).

The content of parsley oil in the content is not limited, and it can be exemplified: preferably 0.05% by mass to 22% by mass, more preferably 0.1% by mass to 10% by mass, and particularly preferably 0.15% by mass to 5% by mass.

The essential oil obtained by steam distillation of plants belonging to the genus Peppermint is separated into de-brained oil and crude brain. Here, menthone oil is obtained from the separated de-brained oil. Menthone oil is commercially available, and for example, it is marketed as menthone oil (manufactured by Nagaoka Industrial Co., Ltd.). It is well known that menthone oil contains menthone as a main component, and the peppermint oil contains menthol as a main component.

The content of menthone oil in the content is not limited, and examples thereof are preferably 1% by mass to 22% by mass, more preferably 3% by mass to 18% by mass, and particularly preferably 5% by mass to 15% by mass.

In addition, although the present invention is not limited, when the content of the present invention contains at least two selected from the group consisting of peppermint oil, caraway oil, and menthone oil, regarding the selection of the content The content of at least two of the group consisting of free peppermint oil, caraway oil, and menthone oil can be exemplified: the total amount is preferably 0.2% by mass to 30% by mass, more preferably 5% by mass to 25% by mass. % By mass, particularly preferably 10% by mass to 20% by mass.

Although the content of the present invention is not limited within this limit, it is preferable to further contain triglycerides.

Triglycerides are compounds having a structure in which three fatty acid esters are bonded to one glycerol. The fatty acid whose ester is bound to glycerol may be a saturated fatty acid or an unsaturated fatty acid. In addition, it may be a straight-chain fatty acid or a branched-chain fatty acid. The carbon number of the fatty acid is also not limited, and examples thereof include a fatty acid having 8 to 22 carbons, more preferably 10 to 21 carbons, and particularly preferably 12 to 20 carbons. Although there is no limitation within this limit, examples of fatty acids include caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, and linolenic acid. , Arachidic acid, behenic acid, lignoceric acid, etc. The three fatty acids bound to one glycerol may be the same, or only two of them may be the same, or different from each other. One type of triglyceride may be used alone, or two or more types may be used in combination.

Triglycerides are for example in sunflower oil, safflower oil, rapeseed oil, olive oil, cottonseed oil, soybean oil, sesame oil, corn oil, peanut oil, grape oil, coconut oil and other vegetable oils, lard, fish oil, tallow and other animal oils, etc. It is also contained in large amounts. Therefore, these vegetable oils, animal oils, etc. can also be used in the contents. These may be used alone or in combination of two or more.

In the case where the content of the present invention contains triglyceride, although the present invention is not limited, in the content, relative to 100 parts by mass of the triglyceride, peppermint oil can be exemplified: preferably 28 parts by mass or less , More preferably, it is 0.5 to 27 parts by mass, particularly preferably 0.5 to 20 parts by mass, and particularly preferably 1 to 12 parts by mass.

In the case where the content of the present invention contains triglycerides, the present invention is not limited, but in the content, relative to 100 parts by mass of the triglycerides, caraway oil can be exemplified: 28 parts by mass or less , More preferably, it is 0.1 to 27 parts by mass, particularly preferably 0.2 to 15 parts by mass, and particularly preferably 0.2 to 12 parts by mass.

In the case where the content of the present invention contains triglycerides, the present invention is not limited, but in the content, menthone oil can be exemplified: 28 parts by mass or less, relative to 100 parts by mass of the triglycerides, It is more preferably 1 part by mass to 27 parts by mass, particularly preferably 1 part by mass to 20 parts by mass, and particularly preferably 5 parts by mass to 20 parts by mass.

The content of the triglyceride in the content is not limited, and it can be exemplified: preferably 60% by mass to 99.95% by mass, more preferably 70% by mass to 99.9% by mass, and particularly preferably 75% by mass to 99.8% by mass.

Although there is no limitation within this limit, when the content contains peppermint oil, the content of triglycerides in the content is not limited, and examples include: preferably 60% by mass to 99.9% by mass, more It is preferably 65% by mass to 99.5% by mass, particularly preferably 70% by mass to 99% by mass.

Although there is no limitation within this limit, when the content contains caraway oil, the content of triglycerides in the content is not limited, and it can be exemplified: preferably 65% by mass to 99.95% by mass , It is more preferably 70% by mass to 99.9% by mass, and particularly preferably 75% by mass to 99.8% by mass.

Although there is no limitation within this limit, when the content contains menthone oil, the content of triglyceride in the content is not limited, and examples include: preferably 65% by mass to 99% by mass, It is more preferably 70% by mass to 97% by mass, and particularly preferably 75% by mass to 95% by mass.

As long as the effect of the present invention is not impaired, the content may further contain optional ingredients such as pharmaceutically acceptable ingredients, cosmetically acceptable ingredients, and edible ingredients, if necessary. As this component, the edible component can be mentioned suitably.

Examples of the optional ingredients include water, plasticizers, colorants, amino acids, vitamins, enzymes, sweeteners, cooling agents, fragrances, excipients, disintegrants, fluidizing agents, and surfactants , Flavoring agents, flavoring agents, suspending agents, wetting agents, emulsifiers, cosolvents, dispersants, buffers, binding agents, penetration enhancers, stabilizers, extenders, preservatives, tackifiers, pH adjusters , Coating agents, absorption enhancers, antioxidants, anti-inflammatory agents, waxes, various useful ingredients, etc. These may be used individually by 1 type, and may be used in combination of 2 or more types, and as long as the effect of this invention is not impaired, the content can also be suitably determined.

The form of the content is not limited, and it may be solid (powder, granular, etc.), semi-solid (gel (gel), cream, paste, etc.), liquid, etc. As the form of the content, a semi-solid form or a liquid form can be preferably exemplified.

The content can be manufactured according to the conventionally known manufacturing process of the content contained in the capsule. For example, at least one selected from the group consisting of peppermint oil, caraway oil, and menthone oil can be selected as needed. The triglyceride and the optional components described above are appropriately mixed to prepare.

Coating In addition, in the capsule of the present invention, the film contains at least one selected from the group consisting of porcine-derived gelatin and fish-derived gelatin.

Porcine-derived gelatin or fish-derived gelatin may be gelatin conventionally used in the fields of food, medicine, quasi-drugs, and the like, and edible gelatin can be preferably exemplified. Although there is no limitation within this limit, as the gelatin, there can be exemplified: chemically treated gelatin, acylated gelatin, etc., using the skin, bone, tendon, ligament, scale, etc. of pig or fish as raw materials Modified gelatin, gelatin hydrolysate and other gelatin. These gelatins may be used alone or in combination of two or more. Pig-derived gelatin or fish-derived gelatin can be obtained commercially, for example, from NIPPI Co., Ltd., Nitta Gelatin Co., Ltd., JELLICE Co., Ltd., Rousselot (Rousselot) ) Company, Weisardt (Weishardt) company and other commercially available.

Although the gelatin derived from pig or the gelatin derived from fish is not limited within this limit, the gel strength (Bloom value) of the gelatin can be appropriately selected and used. Although the present invention is not limited, the gel strength of gelatin can be exemplified: it is preferably in the range of 50 g to 350 g, more preferably in the range of 80 g to 300 g. The gel strength of gelatin can be measured in accordance with Japanese Industrial Standards (JIS) K-6503 (2001). Specifically, a 1/2 inch (12.7 mm) diameter plunger will be used to lower the surface of the gel. The load (g) required at the time of pressing 4 mm was defined as the strength of the gel, which was prepared by cooling a 6.67% by mass aqueous gelatin solution at 10°C for 17 hours.

The content of at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin in the film is not limited, and is selected from the group consisting of pig-derived gelatin and fish-derived gelatin At least one type of is exemplified: preferably 15% by mass to 85% by mass, more preferably 20% by mass to 80% by mass, and particularly preferably 25% by mass to 75% by mass in the total amount in the film.

In addition, although the present invention is not limited, relative to 100 parts by mass of the total amount of at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin, it is selected from peppermint oil and caraway oil And at least one of the group consisting of menthone oil can be exemplified: the total amount is preferably 1 part by mass to 50 parts by mass, more preferably 3 parts by mass to 45 parts by mass, particularly preferably 5 parts by mass to 35 parts by mass Copies.

As long as the effect of the present invention is not impaired, optional ingredients such as pharmacologically acceptable ingredients, cosmetically acceptable ingredients, and edible ingredients may be further contained in the film as needed. As this component, the edible component can be mentioned suitably.

Examples of such optional ingredients include: water, plasticizers, excipients, disintegrants, fluidizers, surfactants, lubricants, fragrances, colorants, sweeteners, correctives, correctives, and suspending agents , Wetting agents, emulsifiers, co-solvents, dispersants, buffers, binding agents, penetration enhancers, stabilizers, extenders, preservatives, tackifiers, oily bases, pH adjusters, coating agents, Absorption enhancers, antioxidants, anti-inflammatory agents, cooling agents, amino acids, vitamins, enzymes, various useful ingredients, etc. These may be used singly or in combination of two or more, and the content may be appropriately determined as long as the effects of the present invention are not impaired. Furthermore, although the present invention is not limited, it is preferable that the film in the present invention does not contain bovine-derived gelatin.

Although the present invention is not limited, when describing the plasticizer as an example of the optional component, examples of the plasticizer include: glycerin; glycols such as propylene glycol or polyethylene glycol; sucrose, fructose, and sorbose Liquid sugars such as alcohol, mannitol, and corn syrup; water-insoluble cellulose such as crystalline cellulose, low-substituted hydroxypropyl cellulose, ethyl cellulose, etc. These can be used individually by 1 type, and can also be used in combination of 2 or more types. In addition, the content of the plasticizer in the film is not limited, and examples thereof are preferably 1% to 45% by mass, more preferably 5% to 35% by mass, and particularly preferably 10% to 30% by mass.

The film can be manufactured according to the manufacturing process of the film used in conventionally known capsules. For example, at least one selected from the group consisting of porcine-derived gelatin and fish-derived gelatin can be selected from the group consisting of gelatin derived from pigs and gelatin derived from fish. The optional ingredients are suitably mixed to prepare.

Capsules In the present invention, in the capsule, the content is contained in the film. Capsules can be manufactured according to conventionally known capsule manufacturing procedures. For example, they can be manufactured by adding at least one selected from the group consisting of peppermint oil, caraway oil, and menthone oil, as required The content prepared by mixing the triglycerides and the optional ingredients as required is enclosed in a film (capsule) which is selected from porcine-derived gelatin and fish-derived At least one of the group consisting of gelatin is appropriately mixed with the optional ingredients as needed to prepare. The capsule of the present invention can be manufactured by enclosing the contents in the film according to a conventionally known manufacturing procedure of capsules such as filling the contents in the film or wrapping the contents with the film.

The capsule of the present invention may be a soft capsule or a hard capsule. In addition, although the present invention is not limited, as the shape of the capsule, there can be exemplified an oval (rugby) type, an oblong type, a round (spherical) type, a tear type, a triangle, etc., as long as it can be taken preferably , There is no limit to its size. For example, in the case of an ellipse, it can be listed as follows: preferably the long diameter is 6 mm-20 mm, the short diameter is 4 mm-15 mm, and the long diameter is 6 mm-15 mm. , The short diameter is 4 mm～10 mm.

The capsule of the present invention can be used in either oral or parenteral form, and is preferably used in an oral form. There is no limitation on the usage of the capsule, and it can be appropriately set according to the purpose. As an example of this usage, when it is used in oral form, it can be used as a food composition (including beverages and health functional foods (including specific health foods, nutritional functional foods, functional foods, supplements, etc.) ), health supplementary food, food for patients), medical composition, quasi-drug composition, feed composition, and additives for food composition, medical composition, quasi-drug composition, feed, etc. The capsule of the present invention may be, for example, one that can be swallowed quickly, or one that stays in the oral cavity for a certain period of time before swallowing.

The subjects to whom the capsule of the present invention is applied (ingestion, administration, etc.) are also not limited, and humans and mammals other than humans can be exemplified. Examples of mammals other than humans include animals such as guinea pigs, rabbits, dogs, cats, monkeys, and chimpanzees.

According to the capsule of the present invention, at least one selected from the group consisting of peppermint oil, caraway oil and menthone oil is used, thereby effectively suppressing the content of gelatin derived from pig or gelatin derived from fish. Insoluble film.

Therefore, it can also be said that the present invention provides a method for inhibiting the insolubilization of the film, which is characterized in that: a capsule having a content and a film encapsulating the content will contain selected from peppermint oil and caraway oil And at least one of the contents of menthone oil, and a film containing at least one selected from the group consisting of porcine-derived gelatin and fish-derived gelatin. In this method, at least one selected from the group consisting of peppermint oil, caraway oil, and menthone oil, at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin One, the content, the film, the capsule, etc. will be described in the same manner as described above. Therefore, it can be said that the method can be carried out by enclosing the contents containing at least one selected from the group consisting of peppermint oil, caraway oil, and menthone oil in a film, the film It contains at least one selected from the group consisting of porcine-derived gelatin and fish-derived gelatin.

According to the present invention, as described above, the insolubilization of the film containing at least one selected from the group consisting of porcine-derived gelatin and fish-derived gelatin can be suppressed, and the effective release contained in the capsule can be more appropriately released. ingredient. [Example]

Hereinafter, the present invention will be described in more detail by showing examples, but the present invention is not limited to these.

Test example Preparation of contents and film According to the composition of Table 1 below, peppermint oil and triglycerides were mixed to obtain a transparent liquid as the content (Example 1 to Example 6, Comparative Example 1 to Comparative Example 3). Except for using menthone oil instead of peppermint oil, in the same manner as described above, a transparent liquid was obtained based on the composition of the following Table 2 (Example 7 to Example 12, Comparative Example 4 to Comparative Example 6). Except for using caraway oil instead of peppermint oil, in the same manner as described above, a transparent liquid was obtained based on the composition of the following Table 3 (Example 13 to Example 18, Comparative Example 7 to Comparative Example 9). Except for using peppermint flavor or lemon flavor instead of peppermint oil, in the same manner as described above, a transparent liquid was obtained based on the composition of the following Table 4 (Comparative Example 10 to Comparative Example 15). In any of the obtained liquids, no solid matter was visually confirmed.

Separately, mix 10 g of porcine-derived gelatin, 20 g of water, and 4 g of glycerin, heat and dissolve the gelatin (80°C), then cool it (25°C), and cut the cooling material into 1.5 pieces each cm×1.5 cm (weight 80 mg) to produce a skin sheet (pig gelatin skin sheet) containing porcine-derived gelatin. Except for replacing pig-derived gelatin with fish-derived gelatin and cow-derived gelatin, a skin sheet (fish gelatin skin sheet) containing fish-derived gelatin and a skin sheet containing bovine-derived gelatin were similarly produced. (Bovine Gelatin Skin Film).

In addition, the brand name peppermint oil (manufactured by Nagaoka Industrial Co., Ltd.) is used for peppermint oil, 95% brand name menthone oil (manufactured by Nagaoka Industrial Co., Ltd.) is used for peppermint oil, and the brand name caraway is used for parsley oil. Oil (manufactured by Xiangrong Industrial Co., Ltd.), brand name Spearmint oil (manufactured by Takasago Fragrance Industry Co., Ltd.) for mint fragrance, brand name lemon oil (manufactured by Ogawa Fragrance Co., Ltd.) for lemon fragrance, three As the acid glyceride, the brand name J sunflower essential oil (manufactured by J-oil Mills (Oil Mills) Co., Ltd.) was used. Furthermore, sunflower oil usually contains about 95% to 100% by mass of triglycerides, and contains triglycerides containing oleic acid and linoleic acid as main constituent fatty acids.

The pig-derived gelatin uses the trade name KKSC (the gel strength described by the manufacturer (the same below) 250 g ~ 280 g), and the fish-derived gelatin uses the trade name SCG-230L (the gel strength 230 g ~ 270 g). The cow-derived gelatin uses trade name #250 (gel strength 235 g～265 g) (all manufactured by Xintian Gelatin Co., Ltd.). Glue strength is a value measured in accordance with JIS K-6503 (2001). Specifically, it is the load required when a plunger with a diameter of one-half inch (12.7 mm) is used to press down on the surface of the glue 4 mm. (G), the glue is prepared by cooling a 6.67 mass% gelatin aqueous solution at 10°C for 17 hours.

After the content and the film sheet were produced, the following insolubilization test was performed. One piece of the gelatin skin film prepared in the manner described above was completely immersed in 4 mL (50°C) of each content prepared in the manner described above in a static state for 1 week. Then, the gelatin film was taken out of the content, washed with hexane, and then the gelatin film was completely immersed in 50 mL of 60°C water (using a 50 mL beaker), and stirred with a stirrer for 5 minutes (rotation speed 670 rpm). Then, visual observation was performed in a static state, and the insolubilization of the gelatin film sheet was evaluated as follows. In addition, all the gelatin film sheets washed with hexane (before water immersion) maintained the shape before immersion in the content.

＜Evaluation＞ ◎: The gelatin film sheet was completely dissolved, and no insoluble matter was confirmed at all. ○: Although the gelatin film sheet was dissolved, slightly (insoluble matter of 10% by mass or less compared with the mass of the gelatin film immediately before water immersion) was confirmed to be insoluble. △: Although the gelatin film sheet is dissolved, many insoluble materials (more than 10% by mass and 50% by mass or less of insoluble matter compared to the mass of the gelatin film immediately before water immersion) are confirmed. ×: The gelatin film sheet is almost insoluble, and very many insolubles (more than 50% by mass of insoluble matter compared with the mass of the gelatin film immediately before water immersion) are confirmed.

result The results are shown in Tables 1 to 4.

[Table 1] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative example 1 Comparative example 2 Comparative example 3 Gelatin Film Porcine Gelatin Porcine Gelatin Porcine Gelatin Fish gelatin Fish gelatin Fish gelatin Bovine gelatin Bovine gelatin Bovine gelatin Contents (mass%) Triglyceride 99 90 80 99 90 80 99 90 80 peppermint 1 10 20 1 10 20 1 10 20 total 100 100 100 100 100 100 100 100 100 Evaluation result (insolubilization inhibition) ◎ ◎ ○ ◎ ◎ ○ △ × × In the table, "pig gelatin" is a gelatin skin film derived from pigs, "fish gelatin" is a gelatin skin film derived from fish, and "bovine gelatin" is a gelatin skin film derived from cattle.

[Table 2] Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Comparative example 4 Comparative example 5 Comparative example 6 Gelatin Film Porcine Gelatin Porcine Gelatin Porcine Gelatin Fish gelatin Fish gelatin Fish gelatin Bovine gelatin Bovine gelatin Bovine gelatin Contents (mass%) Triglyceride 95 85 80 95 85 80 95 85 80 Menthone Oil 5 15 20 5 15 20 5 15 20 total 100 100 100 100 100 100 100 100 100 Evaluation result (insolubilization inhibition) ◎ ◎ ○ ○ ○ ○ △ × ×

[table 3] Example 13 Example 14 Example 15 Example 16 Example 17 Example 18 Comparative example 7 Comparative example 8 Comparative example 9 Gelatin Film Porcine Gelatin Porcine Gelatin Porcine Gelatin Fish gelatin Fish gelatin Fish gelatin Bovine gelatin Bovine gelatin Bovine gelatin Contents (mass%) Triglyceride 99.8 90 80 99.8 90 80 99.8 90 80 Parsley oil 0.2 10 20 0.2 10 20 0.2 10 20 total 100 100 100 100 100 100 100 100 100 Evaluation result (insolubilization inhibition) ◎ ○ ○ ◎ ○ ○ △ × ×

[Table 4] Comparative example 10 Comparative example 11 Comparative example 12 Comparative example 13 Comparative example 14 Comparative example 15 Gelatin Film Porcine Gelatin Fish gelatin Bovine gelatin Porcine Gelatin Fish gelatin Bovine gelatin Contents (mass%) Triglyceride 80 80 80 80 80 80 Mint spice 20 20 20 - - - Lemon spice - - - 20 20 20 total 100 100 100 100 100 100 Evaluation result (insolubilization inhibition) × × × × × ×

As shown in Comparative Example 1 to Comparative Example 3 of Table 1 using peppermint oil, when a bovine gelatin film sheet was used as the film sheet, a large amount of insoluble matter of the film sheet was confirmed. In contrast, as shown in Examples 1 to 6 in Table 1, when a pig gelatin skin film sheet or a fish gelatin skin film sheet was used as the skin film sheet, the insoluble matter of the skin film sheet was hardly confirmed. From these results, it can be seen that peppermint oil is excellent in inhibiting the insolubilization of a pig gelatin film or a fish gelatin film.

In addition, in Table 2 using menthone oil, as shown in Comparative Examples 4 to 6, when a bovine gelatin film sheet was used as the film sheet, a large amount of insoluble matter of the film sheet was confirmed. In contrast, as shown in Examples 7 to 12, when a pig gelatin skin film sheet or a fish gelatin skin film sheet was used as the skin film sheet, the insoluble matter of the skin film sheet was hardly confirmed. From these results, it can be seen that menthone oil is also excellent in inhibiting the insolubilization of a pig gelatin film or a fish gelatin film.

In addition, in Table 3 using caraway oil, as shown in Comparative Examples 7 to 9, when a bovine gelatin skin sheet was used as a skin sheet, a large amount of insoluble matter of the skin sheet was confirmed. On the other hand, as shown in Examples 13 to 18, when a pig gelatin skin film sheet or a fish gelatin skin film sheet was used as the skin film sheet, the insoluble matter of the skin film sheet was hardly confirmed. From these results, it can be seen that caraway oil is also excellent in inhibiting the insolubilization of a pig gelatin film or a fish gelatin film.

On the other hand, in Table 4 using mint flavor or lemon flavor, even pig gelatin skin films (Comparative Examples 10 and 13), fish gelatin skin films (Comparative Examples 11 and 14), and bovine gelatin skin films ( In any of Comparative Example 12 and Comparative Example 15), a large amount of insoluble matter of the membrane sheet was also confirmed.

Therefore, it was confirmed that peppermint oil, menthone oil, and caraway oil are excellent in inhibiting the insolubilization of a film containing porcine-derived gelatin or fish-derived gelatin.

no

no

Claims (6)

A capsule, characterized in that: a content is enclosed in a skin film containing at least one selected from the group consisting of porcine-derived gelatin and fish-derived gelatin, and the content contains selected At least one of the group consisting of free peppermint oil, caraway oil and menthone oil. The capsule according to claim 1, wherein the content further contains triglycerides, and the content contains 28 parts by mass or less of peppermint oil with respect to 100 parts by mass of the triglycerides. The capsule according to claim 1 or claim 2, wherein the content further contains triglycerides, and the content contains 28 parts by mass or less relative to 100 parts by mass of the triglycerides Parsley oil. The capsule according to any one of claims 1 to 3, wherein the content further contains triglycerides, and the content contains 28 parts by mass relative to 100 parts by mass of the triglycerides. Menthone oil in parts by mass or less. The capsule according to any one of claims 1 to 4, which is a soft capsule. A method for inhibiting insolubilization of a film, which is characterized in that: a capsule having a content and a film encapsulating the content is selected from the group consisting of peppermint oil, caraway oil and menthone oil The content of at least one of and a film containing at least one selected from the group consisting of porcine-derived gelatin and fish-derived gelatin.