TW202000250A - Microneedle sheet - Google Patents

Abstract

This invention provides a microneedle sheet having microneedles that fit on the surface of skin. The microneedle sheet includes a sheet-shaped base member (10), a plurality of first microneedles (20) spaced from each other and disposed at a predetermined position of the surface of the base member (10), and a second microneedle (30) of which the length of needle is longer than the first microneedle (20) and which is disposed on the surface of the base member (10) in a residual area of the area provided with the first microneedle (20). At least a tip portion to be inserted into skin of each of the first microneedle (20) and the second microneedle (30) is formed by a substance containing medicine and having solubility in within the body. The second microneedle (30) is disposed on the base member (10) at a position corresponding to a concave area that is more concave than the periphery portion of the area of skin covered by the base member (10).

Description

Microneedle

The invention relates to a microneedle sheet with microneedle.

In the field of beauty, etc., a method of attaching a microneedle sheet having microneedles to the skin and allowing the medicament to penetrate the skin through the microneedles has been developed. For example, a method of dissolving microneedles into the skin by the pharmaceutical component itself has been disclosed. In the invention described in Patent Document 1, single-shaped microneedles that penetrate the skin are regularly arranged.

[Prior Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent No. 6173616

However, there will be irregularities on the surface of the skin. In particular, wrinkles or legal lines on the surface of the face are deeply dented. Therefore, when attaching a microneedle piece with microneedles of a single shape to the skin, the tip of the microneedles cannot reach these areas that are recessed from the surroundings, and the microneedles are not suitable for the skin (lamination, fit) problem occurs.

In view of the above problems, an object of the present invention is to provide a microneedle sheet in which a microneedle is attached to skin.

According to one aspect of the present invention, there is provided a microneedle sheet comprising: a sheet-shaped base; a plurality of first microneedles separated from each other at a predetermined position on the surface of the base; and a second microneedle The needles are longer than the first microneedles, and are arranged on the surface of the substrate in the remaining area of the area where the first microneedles are arranged; wherein at least each of the first and second microneedles The front end portion for penetration into the skin is composed of a substance containing a drug and having in vivo solubility; the second microneedles are at positions corresponding to the recessed areas that are recessed from the surroundings in the area of the skin covered by the substrate, Configured on the substrate.

According to the present invention, it is possible to provide a microneedle piece in which the microneedle is attached to the skin.

10‧‧‧Matrix

11‧‧‧ slit

20‧‧‧The first microneedle

21, 31‧‧‧ Front end

30‧‧‧Second microneedle

22, 32 ‧‧‧ base end

200‧‧‧Skin

210‧‧‧ Nose

300‧‧‧Region

500‧‧‧mold

D21, D22, D31, D32, D33

H2, H3‧‧‧ Needle length

Fig. 1 is a schematic diagram showing the configuration of a microneedle sheet according to an embodiment of the present invention.

Fig. 2 is a schematic diagram showing an example of use of the microneedle sheet according to the embodiment of the present invention.

Fig. 3 is a schematic cross-sectional view showing a state in which the microneedle sheet according to the embodiment of the present invention is applied to the skin.

Fig. 4 is a schematic diagram showing the shape of the second microneedles of the microneedle sheet according to the embodiment of the present invention. Fig. 4 (a) is a side view, and Fig. 4 (b) is a plan view.

FIG. 5 is a schematic diagram showing the shape of the first microneedles of the microneedle sheet according to the embodiment of the present invention. FIG. 5(a) is a side view, and FIG. 5(b) is a plan view.

Fig. 6 is a schematic diagram showing an example of a method of manufacturing a microneedle sheet according to an embodiment of the present invention.

Fig. 7 is a schematic diagram showing the configuration of a microneedle chip according to a modified example of the embodiment of the present invention.

Fig. 8 is a schematic diagram showing the configuration of a microneedle chip according to another modification of the embodiment of the present invention.

Fig. 9 is a schematic diagram showing the configuration of a microneedle chip according to still another modification of the embodiment of the present invention.

Fig. 10 is a schematic diagram showing the shape of the second microneedles of the microneedle chip according to another embodiment of the present invention.

Next, an embodiment of the present invention will be described with reference to the drawings. In the description of the following drawings, the same or similar symbols are attached to the same or similar parts. However, the diagram is a schematic diagram, and it should be noted that the relationship between the thickness and the plane size, the ratio of the thickness of each area, etc. may be different from the real thing. In addition, there may be cases where the relationship or the ratio of the sizes of the drawings differs from each other.

In addition, the embodiments shown below are examples of devices or methods for embodying the technical idea of the present invention. The embodiments of the present invention may be subject to various changes within the scope of the patent application.

The microneedle sheet according to the embodiment of the present invention has microneedles for injecting a drug from the skin of a living body. That is, as shown in FIG. 1, it includes: a sheet-shaped base 10; and a first microneedle 20 and a second microneedle 30 arranged on the surface of the base 10, respectively. Although the details will be described later, the needle length of the second microneedle 30 is set to be longer than that of the first microneedle 20. Here, the "needle length" refers to the length from the base end portion connected to the base 10 of the microneedle to the front end portion.

In FIG. 1, a plurality of first microneedles 20 having a relatively small size in plan view and a plurality of second microneedles 30 having a relatively large size in plan view are disposed on the base 10. The plurality of first microneedles 20 are separated from each other at predetermined positions on the surface of the base 10. The second microneedles 30 are arranged on the surface of the base 10 in the remaining area where the first microneedles 20 are arranged. Hereinafter, the first microneedle 20 and the second microneedle 30 are collectively referred to as "microneedles".

At least the tip of the microneedle for penetration into the skin is composed of a substance containing a drug and having in vivo solubility. Therefore, by sticking the microneedle sheet to the surface of the skin and piercing the microneedle into the skin, the microneedle can be dissolved inside the living body, and the drug can be injected into the skin. Furthermore, the entire microneedle can also be formed by the medicine.

The second microneedles 30 are arranged on the base 10 at positions corresponding to the recessed areas that are recessed from the surrounding area of the skin covered by the base 10. When the recessed region extends, a plurality of second microneedles 30 are arranged on the surface of the base body 10 along the direction in which the recessed region extends. For example, in the microneedle sheet shown in FIG. 1, a plurality of second microneedles 30 are arranged along the decree pattern, which is surrounded by the area 300 shown by the chain line in FIG. 2 and from the nose From both sides, it extends to both ends of the lips. Furthermore, in the second figure, the microneedle sheet is penetrated to show the decree pattern.

The shape of the second microneedle 30 can be appropriately set according to the depth, width, and the like of the recessed region. Furthermore, as shown in FIG. 1, the long axis direction may be matched with the direction in which the recessed region extends, and the second microneedle 30 may have an elliptical shape in plan view.

In addition, as shown in FIG. 1, the size of the second microneedle 30 is larger than the size of the first microneedle 20 in plan view. Thereby, when the microneedle sheet is attached to the surface of the skin, the front end of the second microneedle 30 can easily reach the bottom surface of the recessed region, and the bottom surface of the recessed region is located more than the front end of the first microneedle 20 Deep location.

The base 10 is preferably made of a material having flexibility. As a result, as shown in FIG. 3, the microneedles can be arranged along the curved surface of the surface of the skin 200. This allows the microneedles to penetrate the skin 200 with certainty.

The shape of the second microneedle 30 is, for example, as shown in FIGS. 4(a) and 4(b), and is a conical shape. At this time, as described above, the base end portion 32 may have an elliptical shape in which the long axis direction matches the direction in which the recessed region extends. The needle length H3 of the second microneedle 30 is, for example, about 600 μm. In addition, the width D31 of the tip portion 31 is, for example, about 5 to 15 μm. The width D32 of the base end portion 32 in the long axis direction is, for example, about 300 to 350 μm, and the width D33 in the short axis direction is, for example, about 200 to 250 μm.

The shape of the first microneedle 20 is, for example, as shown in FIGS. 5(a) and 5(b), and is a conical shape. In the example shown in FIG. 5(b), the shape of the first microneedle 20 in a plan view is circular. The needle length H2 of the first microneedle 20 is, for example, about 200 μm. In addition, the width D21 of the front end portion 21 is, for example, about 5 to 15 μm, and the width D22 of the base end portion 22 is, for example, about 100 μm.

For example, as shown in FIG. 6, the microneedle sheet shown in FIG. 1 is made by flowing a raw material containing a medicament injected into the skin into a mold 500 formed by fitting the first microneedle 20 and the second microneedle 30 shaped recesses. According to this manufacturing method, the first microneedle 20 and the second microneedle 30 and the base 10 are integrally formed of the same material.

As described above, in the microneedle sheet according to the embodiment of the present invention, the second microneedle 30 having a long needle length is arranged on the base 10 in accordance with the recessed area on the surface of the skin. In this way, the microneedles can be attached to the skin. That is, the microneedles can penetrate the uneven skin surface evenly. Therefore, even in the recessed area, the medicine can be uniformly injected, and by setting the needle length of the second microneedle 30 to be longer, the medicine can be injected in the recessed area in a focused manner.

In the field of beauty, microneedles composed of, for example, a drug mainly composed of hyaluronic acid or collagen are used. Alternatively, by using microneedles made of therapeutic drugs, the microneedles of the embodiment can also be applied to the medical field.

<variation example>

In the above description, although the base 10 of the microneedle chip is rectangular in plan view, the shape of the base 10 may be arbitrarily set according to the position where the microneedle chip is attached.

For example, the base body 10 may be divided into a plurality of parts in contact with the skin other than the protruding area of the skin. In the microneedle piece shown in FIG. 7, the shape of the base body 10 is set so as to avoid the nose 210.

In addition, as shown in FIG. 8, the slit 11 may be provided in the base 10. The distortion of the base body 10 caused by the unevenness or curved surface of the skin is absorbed by the slit 11, so that the microneedles can be more closely attached to the skin.

In the configuration of the microneedle piece shown in FIG. 9, the base 10 is circular in plan view, and the second microneedle 30 is arranged at the center of the base 10. According to the configuration shown in FIG. 9, it is possible to suppress the deviation of the microneedle piece from the position attached to the surface of the skin.

(Other embodiments)

As described above, although the present invention is described in the embodiments, the discussion and drawings constituting a part of this disclosure should not be construed as limiting the present invention. For those having ordinary knowledge in the technical field, it is possible to reveal various alternative embodiments, examples, and application techniques from this.

For example, in the above, although the microneedle has a conical shape, it may have another shape. For example, as shown in Fig. 10, the microneedles may be pyramid shaped. In addition, although the inclination of the side surface of the microneedle is shown as a fixed example, the inclination may be changed. For example, the closer to the front end, the steeper the slope of the side may be.

In addition, in FIG. 2 and the like, although the example in which the second microneedles 30 are arranged in accordance with the decree pattern is shown, it is of course possible to arrange the second microneedles 30 in accordance with other recessed regions. For example, the second microneedles 30 may be arranged in accordance with wrinkles on the face.

As described above, the present invention naturally includes various embodiments and the like not described herein.

10‧‧‧Matrix

20‧‧‧The first microneedle

30‧‧‧Second microneedle

Claims (9)

A microneedle chip having microneedles for injecting a drug from the skin of a living body, the microneedle chip includes: a sheet-shaped base; a plurality of first microneedles, which are separated from each other at a predetermined position on the surface of the base; and Two microneedles, the needle length is longer than the first microneedles, and are arranged on the surface of the substrate in the remaining area of the area where the first microneedles are arranged; wherein, the first microneedles and the first At least the distal end of each of the two microneedles for piercing the skin is composed of a substance containing the drug and having in vivo solubility; the second microneedles are in the area of the skin covered by the substrate The position corresponding to the recessed area of the surrounding recess is arranged on the aforementioned base. The microneedle sheet according to item 1 of the patent application range, wherein the plurality of second microneedles are arranged on the surface of the base along the direction in which the recessed region extends. According to the microneedle chip described in item 1 or 2 of the patent application scope, the size of the second microneedle is larger than the size of the first microneedle in a plan view. The microneedle sheet according to any one of claims 1 to 3, wherein the shape of the second microneedle is an ellipse in plan view. The microneedle sheet according to any one of claims 1 to 4, wherein the entirety of the first microneedle and the second microneedle is composed of the drug. The microneedle sheet according to any one of claims 1 to 5, wherein the base system is divided into a plurality of parts so as to be in contact with the skin except for the protruding region of the skin. The microneedle sheet according to any one of the items 1 to 6 of the patent application range, wherein the substrate is provided with a slit. The microneedle chip according to any one of claims 1 to 5, wherein the base is circular in a plan view, and the second microneedle is arranged at the center of the base. The microneedle tablet according to any one of the items 1 to 8 of the patent application range, wherein the agent contains hyaluronic acid or collagen as a main component.

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