TW201902524A - Injection device capable of preventing the injection needle from falling off from the injection barrel and enabling the syringe to be attached and detached from the injection device - Google Patents

Abstract

This invention relates to an injection device 1 which injects the content into a subject by using a syringe having a plunger, an injection barrel into which the plunger is inserted, and an injection needle which is composed of a needle base connected to the injection barrel and a needle tube punctured into the subject. The injection device 1 comprises a contact head 10, which is capable of being in contact with the subject, and formed into an opening portion through which the needle tube passes; a movable bracket 30, which holds the injection barrel and the injection needle; a support mechanism 20, which is fixed on the contact head; and a content injection control mechanism 50, which presses the plunger into the interior of the injection barrel. The injection barrel and the injection needle are moved relative to the contact head by moving the movable bracket along the support mechanism. The syringe is detachable with respect to the injection device.

Description

Injection device

The present invention relates to an injection device and, more particularly, to a device adapted to inject, supply, or administer various substances including cells into a tissue.

In cell therapy or the like, it is desirable to inject a predetermined substance such as a cell into a subject at a predetermined depth in a desired amount in a treatment site in the skin. Further, when a substance such as a small amount of cells is injected into a single layer or a single region, it is necessary to divide the predetermined amount into a plurality of times and to perform dispersion injection from a plurality of different directions. Further, in the case where the predetermined amount of the content is divided into a plurality of times and dispersed and injected from a plurality of different directions, it is desirable to divide the influence on the subject into equal divisions. Therefore, it is desirable to divide the plurality of times. Each time, the injection is performed at the same predetermined speed. In order to solve such a problem, Patent Document 1 has been proposed in which an injection needle casing that fixes an injection needle in an injection device is designed, the injection needle is fixed inside, and the syringe is detached (loading and unloading). It is freely mounted on the fixed injection needle. In the injection device, the injection operation can be performed at a predetermined speed by the internal drive system and the retraction system. [Prior Art Document] [Patent Document] [Patent Document 1] Japanese Patent Publication No. 2015-505487

[Problems to be Solved by the Invention] However, in the technique of Patent Document 1, since the injection needle is fixed inside, when a plurality of patients or subjects are used to perform injection using the device, infectious diseases, infectious diseases, and the like The risk of puncture pain caused by infection, abrasion of the injection needle, and the like is high, and therefore it is necessary to make the injection device itself a disposable article. In addition, in the case where the injection device for the target and the injection needle for the syringe are in an integrated structure that cannot be removed, the device is managed as a higher medical device, and the device is also declared or transported. Very strict. Further, as a content to be injected by injection, if a substance having a high viscosity of a gel-like structure is used, the pressure is high during use, and there is a possibility that the syringe will be detached from the fixed injection needle. Sex. Accordingly, the present invention has been made in view of the above circumstances, and an object of the present invention is to provide an injection device which can prevent the injection needle from coming off the syringe and allowing the syringe to come off. [Means for Solving the Problem] According to one aspect of the present invention, an injection device has a syringe having a piston, a syringe inserted therein, and a needle base connected to the syringe and a needle penetrating the inside of the subject The syringe of the injection needle is configured to inject the contents into the subject, and the injection device is characterized in that: the contact head is in contact with the subject, and an opening portion through which the needle tube passes is formed; a holder for holding the syringe and the injection needle; a support mechanism fixed to the contact head; and a content injection control mechanism for pressing the piston into the interior of the syringe. The movable bracket is moved along the support mechanism to move the syringe and the injection needle relative to the contact head. The syringe is detachable relative to the injection device. [Effects of the Invention] According to one aspect of the present invention, the injection device can prevent the injection needle from coming off the syringe and can cause the syringe to come off during use.

FIG. 1 is an explanatory diagram of an injection device according to a first embodiment of the present application. (a) is a schematic view and (b) is a side view. [Overall Description] The injection device 1 is an injection device for attaching a syringe that injects a content including a substance such as a cell suspension into a subject (human, animal, individual organ, skin, etc.). The injection device 1 functions as an injection syringe holder (injector holder) for injecting an appropriate amount of the contents into the subject using a syringe. The injection device has a contact head 10, a support mechanism 20, a movable bracket 30, and a content injection control mechanism 50. The contact head 10 is in contact with the subject and forms an opening. The contact head 10 is located at the front end of the injection device 1. When the needle tube 83 to be described later performs a puncture operation and a needle extraction operation with respect to the subject, the needle portion 83 passes through the opening portion 11 (see FIG. 4(b)). The support mechanism 20 is fixed to the contact head 10 at a predetermined angle. By the joint angle of the support mechanism 20 and the contact head 10, the injection angle with respect to the subject can be set. The contact head 10 and the support mechanism 20 may be integrally manufactured, or may be separately manufactured and then fixed by welding or the like. The support mechanism 20 is a bracket receiving portion that blocks the movable bracket 30 by specifying a stop position of the movement of the movable bracket 30. The movable holder 30 holds the syringe 84 and the injection needle 81 (refer to FIG. 2(a)), and is movable along the support mechanism 20 with respect to the contact head 10. By moving the movable holder 30 relative to the contact head 10, the syringe 84 and the injection needle 81 held by the movable holder 30 can be moved relative to the subject in contact with the contact head 10. By this relative movement, the needle tube 83 of the syringe 80 is movable relative to the subject in the advancing direction as the puncture direction and the retreating direction as the needle pulling direction. The contents injection control mechanism 50 presses the piston 88 against the syringe 84. The content injection control mechanism includes a pressing portion 40, a guide bar 51, a linkage bar 52, a connecting rod 53, and elastic members 54, 55 (see Fig. 5). Here, in the injection device 1 of the present invention, the syringe and the injection needle serve as a syringe, and can be detached. Fig. 2 is an explanatory view of a syringe, (a) showing the assembled syringe, and (b) showing an exploded view of the syringe. As shown in FIG. 2, the syringe 80 is composed of an injection needle 81, a syringe 84, and a piston 88. A cylinder 84 collects the contents in which the piston 88 is inserted. Specifically, the syringe 84 has an outer tubular portion 85 that houses the contents, a flange 86 that is provided at the rear end of the outer tubular portion 85, and a tubular front end 87. Here, in the injection device of the present invention, a syringe having a volume of 1 mL is preferably used. Such a 1 mL syringe can perform 10 100 μL injections or 6 166 μL injections. A syringe with 2, 5 or 10 mL can also be used. The syringe may also have a larger or smaller volume based on the particular form of use of the injection device. The injection needle 81 is connected to the syringe 84. Specifically, the injection needle 81 has a needle base 82 that is externally fitted to the barrel distal end 87 of the syringe 84, and a needle tube 83 that is punctured into the subject. When the syringe 80 is placed, the barrel leading end 87 of the syringe 84 is inserted into the needle base 82 of the injection needle 81 and engaged. A syringe having a structure by which the needle base 82 of the injection needle 81 and the barrel leading end 87 of the syringe 84 are not easily detached can also be used. Here, the diameter of the needle tube of the injection needle applied to the injection device of the present invention is preferably in the range of 18 to 34 G and 20 to 30 G. Further, it is preferably 26G, 27G or 30G. The piston 88 is pressed by the head (rear) 88h to move in the outer tubular portion 85 of the syringe 84, so that the contents can be discharged from the syringe. At the front end portion of the piston 88, a gasket 89 as a packing (sealing member) for preventing leakage of liquid or foreign matter is prevented. Here, in the present invention, the syringe 84 and the injection needle 81 shown in Fig. 2(a) are integrated and can be detached together, so that the contents stored in the syringe 84 are not attached to the injection device 1. The inside or the attachment is extremely small, whereby the injection device 1 can be reused. Here, the syringe 84 and the injection needle 81 may be integrated by at least when the injection device 1 is brought into and out of the injection device 1, and when it is installed outside the injection device 1, the syringe 84 and the injection are placed. The needles 81 may be in a state of being separated from each other. [Moving Support (Syringe Holder)] FIG. 3 is an enlarged cross-sectional view showing the upper surface of the movable holder 30. (a) is a perspective view, and (b) is a cross-sectional plan view taken along A-A' of (a). The movable bracket 30 has a syringe holder formed of a front bracket 310 and a rear bracket 320 at the upper portion, and a movable support that forms two through holes (331, 332, see FIG. 5) through which the rod-shaped members 51, 52, 53 pass. Part 330. Further, the coil springs 54 and 55 as the first elastic members are provided inside the movement support portion 330. The upper portions 310 and 320 of the movable holder have a flange fitting portion 31, an outer tubular portion holding portion 32, a needle base stopper 33, and a circumferential surface holding portion 34. The flange fitting portion 31 is fitted to the flange 86 of the syringe 84. As shown in FIG. 3(b), the flange fitting portion 31 has an outer frame shape of a wing shape in a plan view, and is engaged with the flange 86 by fitting the flange 86 into the outer frame shape. By this engagement, the flange 86 is positioned, thereby restricting the movement of the flange 86 relative to the movable holder 30 in the separation direction (reverse direction, the direction of the arrow B in Fig. 1(b)). The outer tubular portion holding portion 32 holds and holds the position of the outer tubular portion 85 of the syringe 84 from both sides. The outer tubular portion holding portion 32 has a linear rib shape that rises in a rib shape so as to extend along both sides of the side surface of the cylindrical outer tubular portion 85. With this configuration, the outer tubular portion holding portion 32 restricts the displacement in the lateral direction of the outer tubular portion 85 of the movable bracket 30, that is, the offset to the side surface. Even if the movable holder 30 moves, the holding state can be stably maintained. The needle base stop portion 33 limits the movement of the needle base 82 of the injection needle 81. In the example of the syringe shown in Fig. 2, the front end of the needle base 82 has a predetermined planar shape, and the needle base stop portion 33 shown in Fig. 3 is reduced in diameter by the inner diameter (a step is set), and the needle base 82 can be used. Front end face contact. In Fig. 3(a), the needle base stop portion 33 extends vertically in a direction in which it is stopped with respect to the moving direction of the syringe 80, and although the needle tube 83 can pass therethrough, it is a front end of the needle base 82 (perpendicular to the moving direction). The surface of the syringe 80 is in contact with the needle base stop portion 33, thereby restricting the movement of the syringe 80 relative to the movable holder 30. It should be noted that the needle base stopping portion 33 may not be perpendicular to the direction in which the syringe 80 is stopped in the moving direction. For example, the needle base 82 may be stopped by decreasing the shape of the circumference. Alternatively, in the case where the front end of the needle base 82 does not have a vertical surface, and the shape of the needle base 82 is gradually thickened toward the portion connected to the syringe barrel 8 (the needle base 82), the needle base stop portion 33 can also be used. Contact with the side of the needle base 82 limits the movement of the relative movable bracket 30 of the syringe 80. With this configuration, when the syringe 80 is attached to the injection device 1 and during the injection operation, the needle base 82 faces the direction toward the opening portion 11 of the movable holder 30 (the advancing direction, the arrow A of FIG. 1(b) The movement of the direction is limited. The circumferential surface holding portion (needle base circumferential surface holding portion) 34 holds the circumferential surface of the needle base 82 of the injection needle 81 in a circumferential surface shape. It should be noted that the circumferential surface holding portion 34 can also hold the front end of the outer tubular portion 85 of the syringe 84 in a circumferential shape. The circumferential surface holding portion 34 shown in FIG. 3 has a cylindrical shape that covers the entire circumferential surface in the circumferential direction of the tip end of the needle base 82 and the outer tubular portion 85. In addition, the circumferential surface holding portion 34 may not cover the entire circumference, and may have a shape in which the shape of the tip end of the needle base 82 and the outer tubular portion 85 is semicircular. By the circumferential surface holding portion 34, the displacement of the needle base 82 and the lateral direction of the outer tubular portion of the movable holder 30 can be restricted. According to this configuration, when the movable holder 30 moves, it is possible to prevent the movement (offset) in the side direction (short side direction) in the holding state. As described above, in the movable holder 30, the flange fitting portion 31 restricts the movement in the separation direction of the syringe 84 (the backward direction of the arrow B in Fig. 1(b)), and the needle base stopping portion 33 restricts the injection needle 81. The movement of the approaching direction (the advancing direction of the arrow A of Fig. 1(b)), according to which, the combined state of the syringe 84 and the injection needle 81 can be maintained in the moving direction. Therefore, even if the syringe 84 and the injection needle 81 move together with the movable holder 30, it is possible to prevent the injection needle 81 from coming off the syringe 84 and causing the contents to leak into the injection device 1. It should be noted that the outer tubular portion holding portion 32 of the movable bracket 30 may not stand up along the entire portion of the outer tubular portion 85 of the syringe 80. As shown in FIG. 3(a), by providing the flat portion 35 in which a part of the projection of the outer tubular portion holding portion 32 is interrupted, the syringe 80 can be easily inserted into the movable holder 30, whereby the syringe 80 can be lifted and lowered. Operationality. [Support Mechanism] The support mechanism 20 will be described based on Fig. 4 and Fig. 1(b). 4(a) is a perspective view of the contact head 10 and the support mechanism 20, and (b) is a perspective view seen from another direction. (c) is an arrow view along the arrow from the direction in which the contact head 10 and the support mechanism 20 are injected. The contact head 10 and the support mechanism 20 function as a fixing member (main body) that does not move relative to the movable movable bracket 30. The support mechanism 20 is fixed relative to the contact head 10. By the connection angle of the contact head 10 and the support mechanism 20, the contact angle of the needle tube 83 of the syringe 80 with respect to the subject can be set. The angle between the support mechanism 20 for specifying the injection angle and the contact head 10 is preferably any one of 10 to 90 degrees, preferably in the range of 15 to 25 degrees. The support mechanism 20 has an upper surface cover portion 24 and side walls 23, and inside the support mechanism 20, a cylindrical holder guide passage (insertion through hole) 21 for guiding the movement of the movable holder 30 is formed. Here, on the side wall 23 located at the rear end of the support mechanism 20, an opening portion 23A into which the movable bracket 30 is inserted as an entrance of the insertion hole of the bracket guide passage 21 is formed. The lower portion of the holder guiding passage 21 that can move the movable holder 30 along the support mechanism 20 functions as a moving guide rail 22 that guides the movable holder 30 to move. Below the support mechanism 20, a slit (opening) 25 extending in the side direction (injection direction) is provided. By opening the lower portion, it is possible to prevent the distal end of the needle tube 83 from coming into contact with the inside of the injection device 1 when the syringe 80 is disengaged. In the present embodiment, the outer peripheral surface of the inner circumferential surface of the stent guide passage 21 that is inserted into the through hole of the cylindrical insertion end of the movable holder 30 for inserting the distal end of the movable holder 30 (at least the portion holding the injection needle 81) is inserted. In part, it is a shape along the shape of the front end (circumferential surface holding portion 34) of the movable holder 30. As shown in FIGS. 4(a) and 4(c), in the support mechanism 20, the upper side and the two side sides of the bracket guiding passage 21 are covered in a semicircular shape (semi-cylindrical shape). Specifically, the support mechanism 20 has an upper surface cover portion 24 that covers at least the portion of the injection needle 81 and the movable holder 30 that holds the injection needle 81 in the circumferential direction and on the side (the needle base stop portion 33 and the circumferential surface are held) Part 34). Therefore, in the present embodiment, the support mechanism 20 is a housing shape in which the lower portion is opened and the bracket guide passage 21 as a cylindrical insertion hole extending in the moving direction for guiding the movable bracket 30 is provided. In the present embodiment, the side wall 23 of the support mechanism 20 stops the movement (advance movement) of the movable holder 30 in the approaching direction of the contact head 10. That is, the end point of the slide movement is specified. Further, on the side wall 23 of the support mechanism 20, the front end of the guide bar 51 and the front end of the connecting rod 53 are fixed. Specifically, the side wall 23 is provided with a side wall fixing portion 23G that fixes the guide bar 51 and a side wall fixing portion 23J that fixes the connecting rod 53 (see FIG. 5). As shown in FIG. 5, the side wall fixing portions 23G and 23J may also include a fastening member for fastening the guide bar 51, the connecting rod 53, or a subsequent connecting member. It should be noted that the cylindrical casing forming the stent guiding passage may also be open upward (ie, the upper surface covering portion 24 may not be provided). For example, in the present embodiment, the support mechanism 20 has a movement guide rail 22 that guides a part of the movable holder 30 (portion holding the needle portion) to the contact head 10 and a predetermined stop for moving the end. The side wall 23 of the portion can be used. However, as shown in FIGS. 4(a) and 4(c), in the present embodiment, by providing the upper surface cover portion 24, the circumferential surface can guide the front end of the movable holder 30, so that the movement is more stable. effect. In addition, / or, consider the safety or hygiene of the operator. [Content Injection Control Mechanism] In FIG. 5, (a) is an exploded view of the content injection control mechanism 50 of the present invention, and (b) is a content injection control mechanism 50 and a movement support portion located on the lower surface of the movable holder 30. Sectional view of 330. It should be noted that Fig. 5(b) corresponds to a cross-sectional view taken along line BB' of Fig. 1(a). The injection device 1 according to the embodiment of the present invention includes a pressing portion 40 as a content injection control mechanism 50, a guide bar 51, a linkage bar 52, a connecting rod 53, and coil springs (first elastic members) 54, 55. The pressing portion 40 presses the piston 88 into the inside of the syringe 84 held by the movable holder 30. The guide bar 51, the interlocking bar 52, and the connecting rod 53 are rod-like members that control the relative movement of the movable holder 30. The guide bar 51 is engaged with the movable bracket 30 and the pressing portion 40 in a relatively movable manner. The interlocking bar 52 is fastened to the movable holder 30, and is movably engaged with the pressing portion 40. The connecting rod 53 extends in the same linear shape as the interlocking rod 52, and its end (rear end) faces the end (front end) of the interlocking rod 52 so as to be in contact with and separated. Further, the front end of the connecting rod 53 is located inside the movable bracket 30. Further, as shown in FIG. 5(b), the first elastic members (coil springs) 54, 55 are provided inside the movable holder 30. The lower portion of the movable holder 30 shown in FIG. 5(b) shows the movement support portion 330 provided at the lower portion of the portion that holds the syringe 84. In the moving support portion 330, a first through hole 331 into which the guide bar 51 is slidably inserted, and a second through hole 332 in which the front end is slidably inserted into the connecting rod 53 and which are located on the same straight line and fastened to the interlocking bar 52 are formed. The guide bar 51 and the connecting rod 53 are movable relative to the through holes 331, 332 of the movable holder 30, respectively. Further, the interlocking bar 52 is fixed at a predetermined position in the through hole 332 of the movable bracket 30 by the following member 38. After the movable holder 30 moves in the direction approaching the contact head 10, compression is applied to the coil springs (first elastic members) 54, 55 provided from the guide rod 51 and the connecting rod 53 to the inside of the movable holder 30 with respect to the first elastic member. force. The pressing portion 40 is engaged with the guide bar 51 and the interlocking bar 52. The pressing portion 40 is a piston pressing portion that comes into contact with the head portion (rear end portion) 88h of the piston 88 and is pressed into the piston 88 by relative movement. The distance between the movable bracket 30 and the contact head 10 and the distance between the movable bracket 30 and the pressing portion 40 are changed by the restoring force of the coil springs 54, 55 provided on the movable bracket 30. Details regarding the change in distance will be described later based on FIGS. 8 and 9. Here, when the distance by which the movable holder 30 moves is constant, the compressive force applied to the coil springs 54, 55 is constant. Therefore, when the predetermined amount of the content is divided into a plurality of times and the injection amount is equal each time, the compression force of the coil springs 54, 55 and the subsequent recovery thereof are made constant by the movement amount of the movable holder 30. The force is also constant, so the injection action of the same injection speed can be performed every time. On the inner wall of the through holes 331, 332 through which the rod-like members 51, 52, 53 are provided, which are provided at the lower portion of the movable holder 30, as the spring holding members, protrusions 36, 37 are provided (i.e., through holes 331, 332). The smaller part of the diameter). A small diameter portion and a large diameter portion are respectively provided on the guide bar 51 and the connecting rod 53. The small diameter portions 51S and 53S are located near the center of the movable holder 30 in the extending direction of the guide bar 51 and the connecting rod 53, and the large diameter portions 51F and 53F are located on the support mechanism 20 side (front end side) of the movable holder 30. The coil springs 54, 55 are externally fitted to the small diameter portions 51S, 53S of the guide bars 51, 53. A guide bar 51 to which the coil spring 54 is fitted is fitted in the through hole 331. The connecting rod 53 to which the coil spring 55 is fitted and the fixed interlocking rod 52 are fitted in the through hole 332. The tip end of the coil spring (first elastic member) is held on the side surface (segment portion) which is reduced in diameter from the large diameter portions 51F and 53F of the guide bar 51 and the connecting rod 53 to the small diameter portions 51S and 53S, and the rear end is held as The projections 36, 37 of the spring retaining members are on the protruding sides 36S, 37S. It should be noted that the guide bar 51 and the connecting rod 53 are configured to be divided so that the coil springs 54 and 55 can be externally fitted to the small diameter portions 51S and 53S. In the inside of the movable holder 30, the diameter of the distal end of the connecting rod 53 is large, and the large-diameter end portion 53T at the distal end thereof can be separated from the other portions, for example, by fitting of a screw groove and a screw groove. Fasten. Here, in the position on the side of the pressing portion 40 of the projection 37, the position of the large-diameter end portion 53T of the end of the connecting rod 53 and the step of the small-diameter portion 53S contact and engage, which is the movable bracket 30 and the supporting mechanism The distance between 20 is the most left (farthest) position. Further, in the guide bar 51, the side of the pressing portion 40 is preferably designed to be close to the diameter of the through hole 331 and larger than the small diameter portion 51S (that is, the intermediate diameter portion 51M is provided). This is because when the compression force is applied to the coil springs 54, 55 in order to move the needle tube 83 and the spring is restored, even if the engagement method of the engagement of the ratchet mechanism described later is changed, the intermediate diameter portion 51M can be along the through hole. The movement of 332 is performed so that the support mechanism 20 can be relatively smoothly moved relative to the guide bar 51. Here, the distance D2 of the movable bracket 30 from the support mechanism 20 (the distance D described later) _m ) corresponds to the distance D1 between the interlocking rod 5 and the connecting rod 53 before the start of the puncture. By this distance, the injection depth of the injection needle can be set. Here, the injection depth of the needle tube 83 of the injection needle 81 is preferably in the range of 0.5 to 5.5 mm, preferably in the range of 2.0 mm to 3.5 mm. [Pressing Portion] FIG. 6 is an explanatory diagram of the ratchet mechanism in the pressing portion 40. Specifically, it is an exploded view of the pressing portion 40. In the guide bar 51 and the interlocking bar 52, the engaging racks 51r and 52r having inclinations are formed on the circumferential surface of the portion opposed to the pressing portion 40. The pressing portion 40 has a stopper (plate spring) 41 that meshes with the engagement bars 51 and the engagement racks of the interlocking bars 52. In addition, in addition to the brake, the pressing portion 40 is provided with a leaf spring support bar 42 to which the brake 41 is fixed, and a case portion 44 that covers the brake 41. The leaf spring support bar 42 is movably mounted on the support plate 45 fixed to the pressing portion 40. Further, on the opposite side to which the brake 41 is fixed, a button 42h is further provided, and a compression coil spring 43 is externally fitted between the button 42h and the support plate. Here, the engagement between the brake 41 in the pressing portion 40 and the engagement bars 51r and 52r of the guide bar 51 and the interlocking bar 52 is configured as a ratchet mechanism. That is, the pressing portion 40 is relatively movable in the direction toward the movable holder 30 with respect to the guide bar 51 and the interlocking bar 52, and the relative movement from the movable holder 30 in the direction away from the movable direction, that is, in the separating direction (reverse direction) is locked. When the lock of the position of the pressing portion 40 is released when the syringe 80 is attached or detached, the button 42h is pressed against the coil spring 43, and the engagement between the stopper 41 and the engaging racks 51r and 52r is performed. Can be lifted. Specifically, it will be described later based on FIGS. 8 and 9. [Contact Head] FIG. 7 is an enlarged view of the contact head 10. As shown in FIG. 7, the contact head 10 has an upper surface 13, a side surface 14, and a lower surface 12. The upper surface 13 and the lower surface 12 of the contact head 10 have a circular shape, a horseshoe shape, and a polygonal shape. Referring to FIGS. 7(a) to 7(c), the opening portion 11 penetrates the upper surface 13 and the lower surface 12 of the contact head 10. In addition, the needle can pass through the opening portion 11. That is, the opening portion 11 of the contact head 10 penetrates the lower surface 12 of the contact head 10 in a bifurcated direction in which the direction of the movement of the movable holder 30 through the needle tube 83 and the vertical direction of the contact head 10 are performed. Referring to a side cross-sectional view of Fig. 7(a), on the lower surface 12 of the contact head 10, the peripheral surface 12c of the opening portion 11 is formed to be located inside with respect to the other lower surface (for example, the lower surface projection 12e). When the lower surface 12 is configured as described above, when the content is injected into the subject, the lower surface 12 can partially contact the subject, and the periphery of the opening 11 becomes non-contact with the subject. For example, in the case of becoming non-contact, in the embodiment shown in FIG. 7(c), on the circumferential portion of the edge portion of the lower surface of the circular contact head 10, continuous formation along the lower surface is formed. The lower surface protrusion 12e protruding in the surface direction. The top of the circumferential-shaped lower surface protrusion 12e is in contact with the subject so as to surround the periphery of the opening portion 11. It should be noted that the lower surface protrusions 12e are not limited to a continuous shape, and may have a discontinuous shape such as a foot shape. By constituting the lower surface 12 of the contact head 10 in this manner, a predetermined space can be set between the periphery of the opening portion 11 and the subject. Therefore, when a liquid such as liquid leakage or blood flows out from the subject in accordance with the injection operation, the liquid is brought into contact with the lower surface of the periphery of the opening portion 11 of the contact head 10, whereby the liquid can be prevented from adhering to a large area on the lower surface 12. Further, before the puncturing operation and after the plucking operation, the distal end of the needle tube 83 is configured to be located above the portion of the lower surface 12 of the contact head 10 that is in contact with the subject. Specifically, in the needle tube 83 of the syringe suitable for the injection device of the present invention, the length of the needle tube 83 is selected to be used at a stage before the puncture so that the distal end of the needle tube 83 is located at a lower surface than the lower surface of the contact head 10. The part touched by the specimen is also at the upper position. For example, the injection volume can vary at each of the other injection sites of other injection depths. The range of injection lengths determines the length of the injection path in the retraction action of the injection needle. Therefore, the total length of the injection can be predetermined according to the length of the injection needle. The total injection length of the injection needle is preferably from 2.0 mm to 50 mm, preferably from 5.0 mm to 40 mm. By the state in which the distal end of the needle tube 83 of the injection needle 81 is not in contact with the subject before the puncturing operation and the detachment operation, when the injection device is separated from the subject, the subject of the subject is pierced in the needle tube 83. Underneath, it prevents movement in unexpected directions. Therefore, the safety of the injection device can be improved. Further, in order to improve the stability of contact with the subject during operation, and to increase the non-contact space between the opening portion 11 and the subject, the lower surface 12 of the contact head 10 may also be provided. The flange portion 16 of the side surface 14 protrudes. Referring to Fig. 7(b), the opening portion 11 has a long hole shape that is elongated and opened toward the support mechanism 20 from a position corresponding to the injection point on the upper surface. As described above, the shape of the opening portion 11 as viewed from above is formed into a long hole shape as described above, and when the injection operation is performed, not only the injection direction can be clarified, but also the operator who performs the injection operation can perform the needle tube. The time for visual recognition becomes longer. By clarifying the injection direction, the injection action can be performed at a more correct position relative to the target injection point. Further, by making the visible time of the needle tube long, even when the needle tube 83 is abnormally bent or broken, it can be found before the injection operation. Therefore, the abnormal injection action performed on the subject can be prevented in advance. Further, on the lower surface 12 of the contact head 10, as the opening portion 11, in the passing direction of the needle tube 83 with the above-described movement of the injection needle, the portion from the up-and-down direction is set toward the support mechanism 20 and reaches the contact. The shape of the slit of the edge of the lower surface 12 of the head 10. Further, in the lower portion of the support mechanism 20, the two moving guide rails 22 are opened and a slit shape is provided. Thus, by opening the lower side of the support mechanism 20 and the contact head 10, it is possible to prevent the syringe 80 from coming into contact with any portion when the syringe 80 is brought off. Further, in the present embodiment, in order to constitute the magnifying glass, the upper surface 13 of the contact head 10 is preferably in the shape of a mortar or a semicircular shape having a concave inner side. After the upper surface is formed by a magnifying glass, the injection site can be easily visualized. For example, even when it is difficult to directly recognize the light source due to the influence of the light source or the like, it is possible to perform the injection while viewing the opening portion 11 and the needle tube 83 passing through the opening portion 11 by using the magnifying glass. In order to make the effect of the above-described magnifying glass better, on the upper surface, the position corresponding to the injection point of the opening portion 11 is preferably the center of the lower surface (upper surface). Further, even if the opening portion 11 is a long hole, in order to easily recognize the injection point, the mark 17 can be provided near the center. Further, on the side surface 14 of the contact head 10, a linear slit as the positioning groove 15 is formed. This linear slit is used to visualize the mark on the subject at the injection preparation stage described later. By arranging the positioning grooves 15 formed as the slits for visually recognizing the marks formed on the side faces 14 in a line shape, the marks shown in the later-described embodiment can be easily aligned with the positions of the contact heads 10. Further, the slit has a linear shape and has an advantage that surface processing is easy. [Injection Operation] FIG. 8 is an explanatory diagram of an operation in the injection device 1 according to the first embodiment. FIG. 9 is an explanatory diagram of an injection operation flow in the first embodiment. The injection operation in the first embodiment will be described below with reference to Figs. 8 and 9 . In the present embodiment, the content injection control unit 50 performs control so that the contents are injected into the subject, and the needle removing of the needle tube 83 from the expected depth to the surface of the subject is performed. The process is described below. START: Place the syringe filled with the infusion solution on the injection device. At this time, the setting to the start position is performed so that the piston 88 and the pressing portion 40 are in contact with each other (refer to an implementation step to be described later). As a premise, at the beginning, the contact head 10 of the injection device 1 is brought into contact with the subject S. Before the puncture operation, it is assumed that each component of the injection device 1 is in the state of Fig. 8(a). It should be noted that, by the shape of the lower surface of the contact head 10 shown in Fig. 7(a), the tip end of the needle tube 83 is in contact with the subject than the lower surface of the contact head 10 at the stage before the puncture. The portion is also at the upper position, so that the front end of the needle tube 83 does not come into contact with the subject. S1: The operator manually brings the movable holder 30 close to the contact head 10 (puncture action). At this time, by moving the movable holder 30 in the direction (direction indicated by the arrow) close to the contact head 10, the needle tube 83 of the injection needle 81 approaches the subject, punctures the subject, and proceeds to the subject. Internal (enter). Here, the coil springs (first elastic members) 54, 55 provided in the movable holder 30 are compressed. Specifically, the pressing portion 40 is held at a predetermined distance D from the movable bracket 30 together with the interlocking bar 52 fastened to the movable bracket 30. _p Simultaneously moving in the direction of approaching the contact head 10, the distance D _m Shorten (becomes zero) (Fig. 8(a) ⇒ Fig. 8(b)). Here, since the interlocking bar 52 fastened to the movable bracket 30 moves together with the movable bracket 30, the end portions of the pressing portion 40 and the interlocking bar 52 also move together. Further, since the pressing portion 40 moves relative to the stationary guide bar 51, the fitting portion of the guide bar 51 and the pressing portion 40 relatively slides in the advancing direction (the movable bracket 30 side). By the relative movement of the pressing portion 40, the distance between the movable holder 30 and the pressing portion 40 does not change during the puncture operation. Therefore, by increasing the distance between the movable holder 30 and the pressing portion 40, it is possible to prevent the incorporation of air bubbles due to the decompression in which the piston 88 is retracted. Further, by shortening the distance between the movable holder 30 and the pressing portion 40, it is possible to prevent the injection operation from being performed in parallel with the puncture operation in which only the piston 88 advances. In S2, by moving the operator's hand away from the movable holder 30 and moving in the direction of separation from the contact head 10, the needle tube is retracted from the inside of the subject, the needle is pulled out from the subject, and separated from the subject. . Specifically, after the force applied to the forward direction of the movable holder 30 is released (disappeared), the movable holder 30 can be detached from the support mechanism 20 by the restoring force of the coil spring (first elastic member) 54 provided on the movable holder 30. Move in the direction of separation. Here, the relative movement of the opposing rod-like members 51, 52 of the pressing portion 40 in the separating direction (reverse direction) is locked by the ratchet mechanism (FIG. 6). That is, after the movable holder 30 is moved from the contact head 10 in the separating direction, since the pressing portion 40 is stopped together with the stationary unfastened guiding rod 51, the interlocking rod 52 fastened to the movable holder 30 is pressed against the immovable movement. The portion 40 performs positional movement. In other words, in the pressing portion 40, the fitting portion slides toward the movable holder 30 side (advancing direction) with respect to the interlocking rod 52. This action makes the distance D _m Lengthen and make distance D _p Shortening, according to which needle extraction and liquid injection can be performed simultaneously (Fig. 8(b)⇒(c)). With the retracting operation of the movable holder 30, the movable holder 30 is moved in position relative to the guide bar 51, whereby the distance between the movable holder 30 and the pressing portion 40 is shortened. When the distance between the pressing portion 40 and the movable bracket 30 becomes short (D _p ⇒D _p '), the piston 88 is pressed in with respect to the syringe 84, the volume of the syringe 84 becomes small, and the internal liquid can be injected into the subject. Therefore, an appropriate amount of injection operation can be appropriately performed. End (END): The injection device 1 is separated from the subject. At this time, the front end of the needle tube 83 can be separated from the subject by the shape of the lower surface of the contact head 10 of Fig. 7(a) described above. With the above configuration and flow, when the injection device 1 of the present invention performs the injection operation, the syringe 84 and the injection needle 81 in the movable holder 30 can be appropriately held. In particular, by the flange fitting portion 31 and the needle base stopping portion 33, the movement of the syringe 84 and the injection needle 81 in the content injecting direction can be restricted. Therefore, in the case of using a substance having a highly viscous gel-like structure as a content to be injected by injection, although the pressure on the syringe is high during use, the connection state of the injection needle and the syringe is not Undo. Therefore, the injection device 1 can achieve a precise injection operation. <Second Embodiment> Next, a second embodiment will be described. The injection device according to the second embodiment is preferably applied to an injection operation for an extremely shallow position of the subject. In the injection device according to the second embodiment, after the puncture operation, the backward movement (needle removal operation) of the needle is performed in two stages. Specifically, the needle is retracted to a predetermined distance (the needle pulling operation) in conjunction with the injection operation (content ejection operation) of the pressing operation of the piston to the syringe, and thereafter, the injection operation is performed without performing the injection operation. The predetermined distance is the retracting motion of the needle until it is pulled out from the surface of the subject. FIG. 10 is an explanatory view of the injection device 2 according to the second embodiment of the present invention, wherein (a) is a perspective view and (b) is a side view. Figure 11 is an enlarged view of the needle pulling control mechanism of the injection device of Figure 10 . Figure 12 is a perspective oblique view of the injection device of Figure 10. As shown in FIGS. 10 to 12, the injection device 2 of the present embodiment has a needle removing control mechanism 60. In the present embodiment, the content injection control means 50 performs control of the needle retracting operation of the first stage of injecting the contents into the subject while retracting the needle tube from the expected depth to the predetermined position. The needle removing control unit 60 performs a needle retracting operation in a second stage in which the needle tube is at least retracted from the predetermined position to the surface of the subject and the needle is removed without injecting the contents into the subject. Referring to Fig. 11, the needle pulling control mechanism 60 has a control plate 61, two position adjustment pins 62 and 63, two coil springs (second elastic members) 64 and 65, and lock pins 66 and 67. The control board 61 has an upper surface plate 61T and a side panel 61S covering an upper surface portion 24-1 of at least a portion of the support mechanism 20-1 and a side wall 23-1 on the rear end side separated from the contact head 10. The two position adjusting pins (pins) 62, 63 have a large-diameter head and are fitted into the side panel 61S of the control board 61. The coil springs 64 and 65 as the second elastic members are provided (embedded) on the outer circumference of the position adjustment pin, and are held by the side panel 61S of the control panel 61 and the support mechanism 20-1. Two lock pins (elastic pins) 66, 67 are provided on the upper surface of the support mechanism 20-1, and one end is held on the side surface (guide surface) of the circumferential surface holding portion 34-1 of the movable holder 30-1. Further, the lock pins 66, 67 are provided to extend in a direction substantially perpendicular to the moving direction of the syringe 80 (the short side direction of the syringe). Further, in the present embodiment, the engagement projection 39 is provided on the upper surface of the circumferential surface holding portion 34-1 of the movable holder 30-1. The front end portion of the engaging projection 39 has a tapered shape, and the lock pins 66 and 67 are slidably contacted with the vertical surfaces (the bracket side guide surfaces) 39L and 39M of the projection front end. The support mechanism 20-1 has an upper surface portion 24-1 and a side wall 23-1, and a guiding path for guiding the movement of the movable holder 30-1 is formed inside. Similarly to the first embodiment, the side wall 23-1 of the support mechanism 20-1 is opened (opening portion 23O) so as to be inserted into a part of the movable holder 30-1. Here, the shape of the support mechanism 20-1 is different from that of the first embodiment, and is a cutout portion 26 for recessing the upper surface plate 61T of the control plate 61 on the upper surface portion 24-1 of the support mechanism 20-1. . The lock pins 66, 67 are slidably contactable with the vertical faces (support side guide faces) 27L, 27M of the moving direction of the notch portion 26. Further, portions which are recessed with respect to the vertical faces 27L and 27M, that is, the groove portions 28L and 28M in which the slit spaces become large are formed, respectively. The lock pins 66 and 67 are telescopic elastic pins which are slidably movable along the bracket-side guide faces 39L and 39M of the movable holder 30-1 and the grooves 61TL and 61TM engraved on the upper surface plate 61T. When the injection operation is performed, the holder-side guide surfaces 39L and 39M are not in contact with the lock pins 66 and 67 in the state of FIG. 13( a ) to be described later. In this state, after the movable bracket 30-1 is moved, the lock pins 66 and 67 come into contact with the front ends of the bracket-side guide surfaces 39L and 39M, and then move along the bracket-side guide surfaces 39L and 39M (FIG. 11, left direction). ). Then, in the state of FIG. 13(b), the locking pins 66 and 67 are pushed out in the outward direction by the shape of the engaging projection 39 as the convex portion of the movable holder 30, and the groove portion 28L 28M engagement (Fig. 11(a) ⇒ Fig. 11(b)). After the groove portions 28L and 28M are engaged with each other, the control plate 61 and the movable holder 30-1 are moved again, and the grooves 61TL and 61TM of the upper surface plate 61T of the control plate 61 are moved relative to the lock pins 66 and 67 (Fig. 13 (b). ) Figure 13 (c)). After the operator's hand has left, first, the movable holder 30-1 is moved in a state where the lock pins 66 and 67 are engaged with the groove portions 28L and 28M (FIG. 13(c) and FIG. 13(d)). When the predetermined position is reached, the pressing force applied to the outward direction of the lock pins 66 and 67 is lost by the shape of the bracket-side guide surfaces 39L and 39M of the engaging projections 39 as the convex portions of the movable bracket 30-1. Therefore, the engagement of the lock pins 66, 67 and the groove portions 28L, 28M can be released (Fig. 11 (b)). Then, the restoring force of the coil springs 64 and 65 as the second elastic members acts, whereby the control plate 61 and the movable holder 30-1 move together (FIG. 11(b), FIG. 11(a), FIG. 13(d) ) ⇒ 13 (e)), and complete the retreat action. At this time, the lock pins 66 and 67 whose engagement is released slide along the vertical planes (support side guide surfaces) 27L and 27M. Further, in the present embodiment, unlike the first embodiment, the side wall fixing portions 23G and 23J for fixing the guide bar 51 and the connecting rod 53 are not provided on the side wall 23-1 of the support mechanism 20-1. Instead, the pin insertion holes 23P and 23Q into which the position adjusting pins 62 and 63 of the second elastic members 64 and 65 are fitted to the outside are movably inserted. The side panel 61S of the control board 61 is opened for insertion of a part of the movable holder 30-1. In the present embodiment, the front end of the guide bar 51-1 and the front end of the connecting rod 53-2 are fixed to the side panel 61S of the control board 61. On the side panel 61S, a side surface fixing portion 61SG that fixes the guide bar 51 and a side surface fixing portion 61SJ that fixes the interlocking bar 52 (see FIG. 12) are provided. Further, the side panel pin insertion holes 61SP and 61SQ are opened in the side panel 61S of the control panel 61 so that the position adjustment pins 62 and 63 in which the second elastic members 64 and 65 are fitted outside are movably inserted. The side panel 61S of the control panel 61 is in contact with the side wall 23-1 of the support mechanism 20-1 by the puncturing operation. In the needle retracting operation of the first stage, the movable bracket 30-1 is retracted in a state where the side panel 61S of the control panel 61 is in contact with the side wall 23-1 of the support mechanism 20-1. In the second stage of the needle retracting operation, the side panel 61S of the control panel 61 is separated from the side wall 23-1 of the support mechanism 20-1, and the movable bracket 30-1 is retracted. [Injection Operation] FIG. 13 is an operation explanatory diagram of the injection operation in the second embodiment. Fig. 15 is an explanatory diagram of an injection operation flow in the second embodiment. The injection operation in the second embodiment will be described below with reference to Figs. 13 and 14 . START (START): As a premise, the injection point and the mark are marked with the injection template 100 (see FIG. 16), and the syringe 80 (see FIG. 3) is placed on the injection device 2, and The contact head 10-1 of the injection device 2 is in contact with the subject. <Needle Tube Advancing Operation> In S11 of Fig. 14, the operator manually approaches the movable holder 30-1 to the contact head 10 (puncture operation). After the movable bracket 30-1 is moved by a predetermined distance in the direction approaching the contact head 10-1, compression is applied to the first elastic members 54, 55 from the guide bars 51-1 and the connecting bars 53-2 with respect to the first elastic members 54, 55. The force, and the position adjustment pins 62, 63 move together with the movable bracket 30-1 in the direction approaching the contact head 10-1. That is, in Figure 13, the distance D _P And distance D _L While maintaining the same distance, distance D _M Shortening (zeroing), a compressive force is applied to the first elastic members 54, 55 (Fig. 13 (a) - (b)). When the predetermined position is reached, the lock pins 66, 67 are engaged with the groove portions 28L, 28M of the support mechanism 20. Thereafter, in a state in which the lock pins 66, 67 are fitted to the groove portion of the support mechanism 20-1, the position adjustment pins 62, 63 and the control plate 61 are moved in the direction (advancing direction) of the contact head 10-1. Ie, distance D _M Distance zero while maintaining the same distance _P Also remains the same, at the same time, distance D _L Shortening (zeroing), a compressive force is applied to the second elastic members 64 and 65 (Fig. 13 (b) ⇒ (c)). <Needle Tube Retraction Operation> As S12 of Fig. 14, the operator separates the hand from the movable holder 30-1. After the application of the force of the movable bracket 30-1 in the approaching direction of the contact head 10-1 disappears, the position adjusting pins 62, 63 and the lock pin 66 are restored by the restoring forces of the first elastic members 54, 55 as the first stage. The position of 67 is unchanged, and the movable holder 30-1 moves in a direction away from the support mechanism 20-1 and close to the pressing portion 40, thereby injecting the contents into the subject, and retracting the needle 83 from the expected depth to Pre-determined location. That is, while the distance Dl remains the same, the distance D _M Variable length, distance D _P Shorter (D _P ') According to this, the retreat and injection operation of the predetermined distance can be performed (Fig. 13 (c) ⇒ (d)). As a retreating operation of the second stage of S13 in Fig. 14, the lock pins 66 and 67 are disengaged (to be released from the fitted state), and the positions of the position adjustment pins 62 and 63 and the control board 61 are moved, whereby The restoring force of the elastic members 64 and 65 is moved by the movable holder 30-1, the guide rod 51, the connecting rod 53 fitted to the contact, and the pressing portion 40 of the interlocking rod 52. Ie, distance D _M Constant, distance D _P 'Keeping the same distance, distance D _L According to this, the needle tube 83 can be retracted from the predetermined position to the position where the needle can be removed from the subject without performing the injection operation (Fig. 13 (d) - (e)). With the above configuration and flow, when the injection device 2 of the present invention performs the injection operation, the syringe 84 and the injection needle 81 in the movable holder 30-1 are appropriately held. In particular, by the flange fitting portion 31 and the needle base stopping portion 33, the displacement of the syringe 84 and the injection needle 81 in the moving direction at the time of content injection is restricted. Therefore, in the case of using a substance having a highly viscous gel-like structure as a content to be injected by injection, although the pressure on the syringe is high in use, the connection state of the injection needle 81 and the syringe 84 is also Will not be solved. Therefore, the injection device 2 can realize a precise injection operation. Further, in the present embodiment, since the retreat is performed in two stages, the needle can be pulled after the end of the injection operation. Therefore, when a small amount of valuable content such as cells is injected at a very shallow position of the subject, an injection operation in which the injected contents do not overflow from the surface of the subject can be performed. [Application Step] In order to determine the injection site or the injection direction, before the injection, the hole in the center of the injection template 100 is aligned with the center of the injection site (Fig. 15 (b)), and the sterilization is performed in alignment with the six longitudinal holes. The oily pen after the mark is made (Fig. 15(c)). When the same portion is not subjected to the intermittent injection, the injection site is marked with a cosmetic dye or the like. When injecting into a hairy part such as a scalp, the periphery of the injection site is shaved in advance. Before the injection, the periphery of the injection site is disinfected and dried, and anesthesia is performed. The syringe 80 is taken out of the package and the infusion solution is filled into the inside of the syringe 85. In order to place the syringe 80 on the injection device 1, the button 42h at the rear end of the pressing portion 40 is pressed to slide to the rearmost end on the side opposite to the contact head 10 (Fig. 16 (a)). With regard to the syringe 80 containing the test preparation and to which the injection needle 81 and the piston 88 are connected, the needle tip (the front end of the needle tube) is carefully placed in contact with the main body 10, 20 or the like of the injection device 1 while being carefully placed. On the movable bracket 30 of the device 1. Specifically, as shown in Fig. 16 (b), the syringe 80 is obliquely inserted from the needle tip, and the flange (wing) 86 of the syringe 84 is raised and pressed horizontally (Fig. 16(c), ( d)). Next, the flange 86 is rotated to be engaged with the flange fitting portion 31 (Fig. 16(e)). Thereafter, the pressing portion 40 of the injection device 1 is slowly moved to come into contact with the head portion 88h of the piston 88 to complete the preparation work (Fig. 16 (f), Fig. 16 (g)). Using the injection device 1 (Fig. 17 (a)) in which the syringe 80 is attached, the mark made by the sterilized oil pen is aligned with the positioning groove of the contact head 10. In this state, the contact head 10 is pressed tightly against the scalp (Fig. 17 (b), start (START) of Fig. 8). In this state, the movable holder 30 is manually pushed into the contact head 10 side, whereby the needle tube 83 of the injection needle 81 that moves together with the movable holder 30 is inserted into the scalp (corresponding to S1 of Fig. 8). At this time, it was confirmed that the needle tube 83 was punctured into the scalp by visually recognizing the long hole-shaped opening portion 11 at the center portion of the contact head 10 from above. Thereafter, by slowly withdrawing the hand from the movable holder 30 of the injection device 1, the preparation is injected into the scalp (corresponding to S2 of Fig. 8). Next, after the injection operation is completed, the injection device 1 is separated from the scalp (corresponding to the end (END) of FIG. 8). In the case where a plurality of injections are made in different directions from the same injection site, the marks of the oil-based pen on the skin are aligned with the grooves 15 provided around the contact head 10 in other directions, and the above-described injection operation is repeatedly performed. By repeating such an operation at six positions as injection symbols, when a 1 mL syringe is used, a total of 1.0 mL of the test preparation can be injected. In the injection device after use, the syringe 84 and the injection needle 81 are removed and discarded, and then washed and maintained, and packaged and sterilized using another sterilization bag. For sterilization, any of autoclave, EO gas, gamma sterilization, or the like can be used. Here, according to the above configuration, in the injection devices 1 and 2, since the connection state of the syringe 84 and the injection needle 81 is maintained, it is considered that the contents are substantially not leaked. To the inside of the injection devices 1, 2. Therefore, the cleaning or sterilizing step can be carried out as much as possible on the lower surface 12 of the contact head 10, and the injection device in which the syringe is mounted can be substantially ignored as compared with the injection device of the previous example in which the detachment of the syringe can be expected. Internal pollution. The content (substance) used in the injection device according to the embodiment of the present invention described above can be composed of a cell suspension, a gel material, a therapeutic substance, a cosmetic substance, and a diagnostic substance. Make a choice. For example, the content (substance) used in the above injection device can be selected from the group consisting of a cell suspension, a gel material, a therapeutic substance, a cosmetic substance, and a diagnostic substance. The cosmetic substance to be injected may include fat cells such as a filler, hyaluronic acid, or botulinum toxin (Botox, Btx) for wrinkle treatment, but It is not limited to this. The therapeutic substance may include antibiotics, anesthetics, analgesics, vaccines, and antibodies, but is not limited thereto. Further, the injection device of the present invention can also be used in order to inject cells in a suspension or a liquid medium in a suspension which is a content stored in a syringe into a subject. In addition, as a content stored in the syringe, the cell suspension can also be mixed with developmental factors. Alternatively, the cell suspension may also comprise a gelatinous structure. Such a gel-like structure is preferably a mixture of extracellular matrix proteins which mimic the extracellular environment of other tissues, and is preferably a gelatinous structure such as hyaluronic acid. Further, in order to inject a substance into other tissues of the subject, an injection device according to an embodiment of the present invention can also be used. In particular, in the treatment of hair loss such as hair loss or baldness or other symptoms associated with lack or lack of hair, an injection device can be used when injecting cells into the skin as a cell suspension. Further, the injection device of the present invention is preferably used for injecting a liquid such as a drug, a cytokine, or a development factor into a subject. This application of the liquid to the subject is preferably performed with respect to treatment for hair loss, baldness, or other symptoms associated with lack or lack of hair. Alternatively, the injection device of the embodiment of the present invention may be used to inject a substance into the muscle of the subject or to inject the substance into the tendon of the subject. In addition, the subject to which the injection device according to the embodiment of the present invention is applied is not limited to a person (subject), and may be an animal such as a fish or a mouse. Alternatively, the subject may be a tissue such as a skin or an organ extracted from an experimentee or an animal to be tested. The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific embodiments described above, and various modifications may be made within the scope of the gist of the invention described in the claims. change.

1, 2‧‧‧ injection device

10,10-1‧‧‧Contact head

11‧‧‧ openings

12‧‧‧ Lower surface

12c‧‧‧Central part of the lower surface

12e‧‧‧ lower surface protrusion

13‧‧‧ upper surface

14‧‧‧ side

15‧‧‧Positioning trench

16‧‧‧Flange

17‧‧‧ mark

20, 20-1‧‧‧Support institutions

21‧‧‧ bracket guiding channel (insertion hole)

22‧‧‧Mobile guide rail

23‧‧‧Sidewall of the support mechanism

23G, 23J‧‧‧ sidewall fixing

23O‧‧‧ Opening

23P, 23Q‧‧ ‧ pin insertion hole

24‧‧‧ Upper surface cover of the support mechanism

24-1‧‧‧ Upper surface of the support mechanism

25‧‧‧The lower surface opening of the support mechanism

26‧‧‧Incision Department

27L, 27M‧‧‧ vertical plane (support side guide surface)

28L, 28M‧‧‧ Ditch

30, 30-1‧‧‧ movable bracket (holder)

31‧‧‧Flange fitting

32‧‧‧Outer tube clamping

33‧‧‧ Needle-based stop

34‧‧‧Circumferential surface retention

34-1‧‧‧Circumferential surface retention

35‧‧‧Flat Department

36, 37‧‧‧ protrusions (spring holding parts)

36S, 37S‧‧‧ protruding side

38‧‧‧Next parts

39‧‧‧Clamping protrusion

39L, 39M‧‧‧ vertical plane (support side guide surface)

40‧‧‧ Pressing section (injection control mechanism)

41‧‧‧Brake (plate spring)

42‧‧‧Sheet spring support rod

42h‧‧‧ button

43‧‧‧ Pressing spring

44‧‧‧Upper cover

50‧‧‧Content injection control mechanism

51, 51-1‧‧‧ Guide rod

51F‧‧‧Great Path Department

51M‧‧‧Medium Department

51r‧‧‧Kinematic rack

51S‧‧‧Little Trails Department

52‧‧‧ linkage rod

52r‧‧‧Kinematic rack

53, 53-1‧‧‧ Connecting rod

53F‧‧‧Great Path Department

53S‧‧‧Little Trails Department

End of the large diameter of the 53T‧‧‧ connecting rod

54, 55‧‧‧ coil spring (1st elastic part)

60‧‧‧Control agency

61‧‧‧Control panel

Side panel of 61S‧‧‧ control panel

61SG, 61SJ‧‧‧ side panel fixing

61SP, 61SQ‧‧‧ side panel pin insertion hole

61T‧‧‧ upper surface plate of the control panel

61TL‧‧‧Ditch

61TM‧‧‧Ditch

62, 63‧‧‧Mobile adjustment pin

64, 65‧‧‧ coil spring (2nd elastic part)

66, 67‧‧‧ lock pin

80‧‧‧Syringe

81‧‧‧Injection needle

82‧‧‧ needle base

83‧‧‧ needle

84‧‧‧Syringe (syringe)

85‧‧‧Outer tube

86‧‧‧Flange

87‧‧‧ tube front end

88‧‧‧Piston

88h‧‧‧ piston head

89‧‧‧ cushion

100‧‧‧Injection template

310‧‧‧ front bracket

320‧‧‧ rear bracket

330‧‧‧Mobile support

331‧‧‧1st through hole

332‧‧‧2nd through hole

A‧‧‧ Forward direction

B‧‧‧Retreating direction

B-B’‧‧‧ cross-section

D _L ‧‧‧Distance

D _m ‧‧‧Distance

D _p ‧‧‧Predetermined distance

D _p '‧‧‧Distance

[Fig. 1 (a) and (b)] are explanatory views of an injection device according to a first embodiment of the present invention. [Fig. 2 (a), (b)] A configuration diagram of a syringe applied to the injection device of the present invention. [Fig. 3 (a) and (b)] are explanatory views of the movable holder in the injection device of Fig. 1. [Fig. 4 (a) to (d)] are explanatory views of the movable holder and the support mechanism in the injection device of Fig. 1. [Fig. 5 (a) and (b)] explanatory views of the moving mechanism and the rod member located on the lower surface of the movable holder shown in Fig. 4 . Fig. 6 is an explanatory view of a ratchet mechanism of a pressing portion in the injection device of Fig. 1. [Fig. 7 (a) to (c)] explanatory views of the contact head in the injection device of Fig. 1. [Fig. 8 (a) to (c)] FIG. 8 is a view explaining the operation of the injection device according to the first embodiment of the present invention. [Fig. 9] An explanatory diagram of an injection operation flow in the first embodiment. [Fig. 10 (a) and (b)] An injection device according to a second embodiment of the present invention. [Fig. 11 (a), (b)] An enlarged view of the needle removing control mechanism of the injection device of Fig. 10. [Fig. 12] A perspective oblique view of the injection device of Fig. 10. [Fig. 13 (a) to (e)] FIG. 13 is a view explaining the operation of the injection device according to the first embodiment of the present invention. [Fig. 14] An explanatory diagram of an injection operation flow in the second embodiment. [Fig. 15 (a) to (c)] explanatory diagrams when the subject is marked with an injection template. [Fig. 16 (a) to (g)] explanatory views of the mounting procedure of the syringe. [Fig. 17 (a), (b)] A syringe device in which a syringe is attached and a diagram in which the injection device is brought into contact with the subject.

Claims (23)

An injection device for injecting a content into a sample by a syringe having a piston, a syringe into which the piston is inserted, and a needle connected to the syringe and a needle that is punctured into the subject The injection device is characterized in that it has: a contact head that can be in contact with the subject and forms an opening through which the needle tube passes; a movable bracket that holds the syringe and the injection needle; a support mechanism that fixes And the content injection control mechanism presses the piston into the interior of the syringe, and the movable bracket moves along the support mechanism to move the syringe and the injection needle relative to the contact head. The syringe is detachable relative to the injection device. The injection device according to claim 1, wherein the content injection control mechanism has a pressing portion that presses the piston into the syringe, and the movable holder moves toward a direction in which the contact head is moved, so that the The needle punctures the subject and enters the inside of the subject, and the movable holder moves in a backward direction away from the contact head, and the needle holder is moved back relative to the subject, and the movable holder is brought close to the pressing portion. And pressing the piston into the syringe to inject the contents into the subject. An injection device according to claim 2, wherein the syringe has an outer tubular portion that houses the contents and a flange that is provided at a rear end of the outer tubular portion, the movable bracket having a fitting with the flange A flange fitting portion that holds the movement of the flange relative to the movable bracket in the backward direction. The injection device according to claim 3, wherein the movable holder has an outer cylindrical portion sandwiching portion that sandwiches and holds the outer cylindrical portion by protrusions rising along both sides of the side portion of the outer tubular portion. The outer tubular portion holding portion restricts displacement of the outer tubular portion with respect to a side surface direction of the movable bracket. The injection device according to claim 2, wherein the movable holder has a needle base stopping portion that stops and holds the movement of the injection needle by a protrusion that comes into close contact with the front end of the needle base, and the needle base stopping portion The movement of the needle base relative to the movable bracket in the forward direction is restricted. The injection device according to claim 2, wherein the movable holder has a circumferential surface holding portion that holds the needle base in a circumferential shape, and the circumferential surface holding portion restricts displacement of the needle base with respect to a side surface direction of the movable holder . The injection device according to claim 2, wherein the content injection control mechanism has a guiding rod movably engaged with the movable bracket and the pressing portion; the linkage rod is fastened to the movable bracket and is opposite The pressing portion is movably engaged; and the connecting rod extends in a straight line shape similar to the interlocking rod, and the rear end faces the front end of the linking rod to be contacted and separated, and the rear end is located inside the movable bracket . The injection device according to claim 7, wherein the interlocking bar and the guiding bar have a slanted engaging rack on a circumferential surface of a portion opposite to the pressing portion, the pressing portion having the interlocking bar and a latching engagement gear of the guiding rod, the pressing portion forming a ratchet mechanism, the ratchet mechanism being opposite to the linking rod and the guiding rod in a direction approaching the movable bracket and pressing the piston into the inside of the syringe Movement, the movement of the ratchet mechanism in a direction away from the movable bracket is locked. The injection device according to claim 7, wherein the movable bracket is provided with a first elastic member having a moving support portion at a lower portion of a portion holding the syringe, the guide rod being formed on the movable support portion a first through hole that is slidably inserted, and a second through hole that is slidably inserted into the connecting rod and that is located on the same straight line and fastens the second through hole of the connecting rod, and the movable bracket moves toward the forward direction of the contact head Thereafter, a compressive force is applied to the first elastic member from the guide rod and the connecting rod with respect to the first elastic member, and the movable bracket is moved away from the support mechanism by the restoring force of the first elastic member. mobile. The injection device according to claim 9, wherein a spring holding member projecting from the inner wall is provided on an inner wall of the first through hole and the second through hole, and the guide bar and the connecting rod are respectively a small diameter portion and a large diameter portion are provided, and the small diameter portion is located near a center of the movable bracket in an extending direction of the guiding rod and the connecting rod, and the large diameter portion is located at a front end side of the movable bracket, the first elastic portion The front end of the member is held on the side surface which is reduced in diameter from the large diameter portion of the guide bar and the connecting rod, and the rear end of the first elastic member is held by the spring holding member. The injection device according to claim 10, characterized in that the side wall of the rear end side of the support mechanism is opened for a part of the movable holder to be inserted, and the front end of the guide rod and the front end of the connecting rod are fixed. When the movable bracket moves toward the advancing direction of the contact head, the side wall of the supporting mechanism comes into contact with a part of the movable bracket, and the movement of the movable bracket to the forward direction of the contact head is stopped. When the movable holder moves in the backward direction away from the contact head by the restoring force of the first elastic member, the contents are injected into the subject, and the needle is retracted from the intended depth to the surface of the subject. Take the needle. The injection device according to claim 11, wherein the support mechanism has an upper cover that covers at least the injection needle and a portion of the movable holder that holds the injection needle in the circumferential direction and the side, the movable holder is inserted The interior of the support mechanism. The injection device according to claim 2, characterized in that the injection device further has a needle pulling control mechanism that controls the needle retracting action of the first stage, which is to cause the needle tube to retreat to the object relative to the subject Positioning the movable holder into the pressing portion and pressing the piston into the syringe to inject the contents into the subject, the needle removing control mechanism controlling the second stage of the needle retracting action, which is not The contents are injected into the subject, and the needle tube is at least retracted from the predetermined position to the surface of the subject and the needle is pulled. An injection device according to claim 13, wherein the needle pulling control mechanism has a control board having an upper surface plate covering an upper surface of at least a portion of the support mechanism and a side wall covering a rear end side of the contact head Side panel; 2 position adjustment pins having a large diameter head and inserted into the side panel of the control panel; a second elastic member embedded in the outer side of the position adjustment pin and disposed to be side panel with the control panel And the support mechanism; and two elastic pins disposed on the upper surface of the support mechanism, one end is held on a side of a portion of the circumferential surface holding portion of the movable bracket, and is disposed substantially along the syringe Extending in a vertical direction, the support mechanism has an upper surface and a side surface, and forms a guiding path for guiding the movement of the movable bracket. On the upper surface of the supporting mechanism, two fittings are formed with the elastic pin. In the groove portion, an insertion hole as an inlet of the guide path into which the position adjusting pin of the second elastic member is fitted is formed on the side surface of the support mechanism. The injection device according to claim 14, wherein the content injection control mechanism has a guiding rod movably engaged with the movable bracket and the pressing portion, and the linkage rod is fastened to the movable bracket, and is relatively The pressing portion is movably engaged with the connecting rod, and extends in a straight line shape similar to the interlocking rod, and the rear end faces the front end of the interlocking rod so as to be contacted and separated, and the rear end is located inside the movable bracket a side wall of the rear end side of the support mechanism is opened for inserting a part of the movable bracket, the side panel of the control panel is opened for a part of the movable bracket to be inserted, and the guide is fixed a front end of the rod and a front end of the connecting rod, wherein the side panel of the control panel contacts a portion of the movable bracket after the movable bracket is moved toward the forward direction of the contact head, by the side of the control panel The panel is in contact with the side of the support mechanism to stop the movement of the movable bracket in the forward direction of the contact head, and the needle is retracted in the first stage In the state in which the side panel of the control panel is in contact with the side surface of the support mechanism, the movable bracket approaches the pressing portion, and the movable bracket moves in the backward direction, and the needle is retracted in the second stage. In operation, the side panel of the control panel is separated from the side of the support mechanism, and the movable bracket moves in a backward direction while a predetermined distance between the movable bracket and the pressing portion is maintained. The injection device according to claim 15 characterized in that, in the needle pulling control mechanism, the movable bracket is provided with a first elastic member, and the movable bracket is moved by a predetermined distance in a direction approaching the contact head, and is opposite to the first The elastic member applies a compressive force from the guide bar and the connecting rod to the first elastic member provided inside the movable bracket, and then the elastic pin moves together with the movable bracket in a direction approaching the contact head to reach After the predetermined position, the elastic pin engages with the groove portion, and then the position adjusting pin and the control plate move in the direction of the contact head in a state where the elastic pin is fitted to the groove portion of the support mechanism. A compressive force is applied to the second elastic member. The injection device according to claim 16, characterized in that, after the application of the force of the movable holder in the direction of the contact head disappears, as a first stage, the position adjustment pin and the elasticity are obtained by the restoring force of the first elastic member The position of the pin is unchanged, and the movable bracket moves in a direction away from the support mechanism and close to the pressing portion, and the content is injected into the object and the needle tube is retracted from a predetermined depth to a predetermined position. In the second stage, the elastic pin is disengaged, and the position adjusting pin and the position of the control board are moved, whereby the movable bracket and the pressing portion fitted to the guiding rod are performed by the restoring force of the second elastic member. Move, thereby causing the needle to retreat from a desired depth to a predetermined position. The injection device according to claim 1, characterized in that, on the lower surface of the contact head, the surface of the periphery of the opening portion is configured to be located inside with respect to the other lower surface, when the contents are injected into the object The lower surface is in contact with the subject portion, and the periphery of the opening portion is not in contact with the subject. An injection device according to claim 18, characterized in that a projection projecting in a surface direction of the lower surface is continuously or intermittently formed on an edge portion of the lower surface of the contact head, the upper surface of the projection surrounding the The manner of the periphery of the opening is in contact with the subject. The injection device according to claim 18, wherein the front end of the needle tube is located above the portion of the lower surface of the contact head that is in contact with the object before the start of the puncture operation and after the end of the needle removal operation . The injection device according to claim 1, characterized in that the opening portion of the contact head is opposite to the lower surface of the contact head in a direction in which the needle tube passes with the movement of the movable holder and a bifurcation direction of the up and down direction of the contact head The opening is formed, and the opening portion of the upper surface of the contact head has a long hole shape that extends from the position corresponding to the injection point and that is elongated and opened toward the support mechanism. The injection device according to claim 1, characterized in that the support mechanism has a circumferential guide rail-shaped moving guide rail slidably supported by at least a portion of the movable bracket. An injection device according to claim 22, characterized in that the lower portion of the moving guide rail of the support mechanism is opened so that the needle tube does not make contact when the syringe is disengaged, and the lower portion of the contact head serves as the opening portion In a direction in which the needle tube passes in accordance with the movement of the movable holder, a slit shape is formed from a portion penetrating in the up-and-down direction toward the support mechanism and reaching an edge portion of the lower surface of the contact head.