TW201828884A - Electrode sheet - Google Patents

Abstract

A problem to be addressed by the present invention is to provide an electrode sheet which is easy to align. Provided is an electrode sheet 1, comprising a sheet-shaped flexible substrate 10, and a vital sign acquisition unit 11 which is positioned upon the flexible substrate 10 and which acquires vital signs from a lifeform. The vital sign acquisition unit 11 further comprises: an electrical signal acquisition unit 14 which is positioned upon the flexible substrate 10 and which is capable of electrically acquiring a vital sign; and a plurality of optical signal acquisition units 15 which are positioned upon the flexible substrate 10 and which, by irradiating the lifeform with light, acquire a vital sign which is obtained on the basis of the irradiated light.

Description

   Electrode pad   

The present invention relates to an electrode sheet.

So far, a simple type of electroencephalograph with an integrated electric shock and measuring instrument has been known. With regard to simple electroencephalographs, the burden on patients due to long-term measurement using hard electrodes cannot be ignored, and the electrode structure is fixed, so it is difficult to obtain biomedical signals that meet the requirements of patients and physicians. In addition, in this simple electroencephalograph, a fixing device such as a headset for fixing the head is required.

Therefore, as a device that can more easily measure an electroencephalogram, a biomedical sensor including electrodes and optical elements in a flexible resin sheet that can be attached to a forehead has been proposed (for example, refer to Patent Document 1). According to the proposed biomedical sensors, other signals can also be obtained with optical elements while acquiring brain waves with electrodes.

    [Previous Technical Literature]         [Patent Literature]    

[Patent Document 1] US Patent Publication No. 2016/0015281

Incidentally, there are individual differences in the positions where the signals are obtained by the electrodes and the optical elements. Therefore, the electrodes and optical components are ideally designed and installed in a way that can obtain biomedical signals. Regarding the proposed biomedical sensor, although the electrodes are in contact with the center position of the forehead, other electrodes and optical elements are not set according to individual differences. Therefore, in order to obtain a signal, it is necessary to repeatedly calibrate the position of the electrode and the optical element to the living body.

An object of the present invention is to provide an electrode sheet whose position can be easily adjusted.

(1) The present invention relates to an electrode sheet, including: a one-piece flexible substrate; and a life-medical signal acquisition unit configured on the flexible substrate and obtaining a bio-medical signal of a living body; The medical signal acquisition section includes: an electrical signal acquisition section, which is arranged on the flexible substrate and can obtain the biomedical signal electrically; and a plurality of optical signal acquisition sections, which are arranged on the flexible substrate, and The living body irradiates light to obtain a biomedical signal based on the irradiated light.

(2) Preferably, the electrical signal acquisition unit is disposed in an area obtained by bisecting one surface of the flexible substrate in a straight line, and the optical signal acquisition unit is disposed in another area.

(3) Preferably, the electrical signal acquisition section includes a plurality of electrodes arranged in a predetermined direction along the surface of the flexible substrate, and the optical signal acquisition section includes a plurality of electrodes arranged in a direction substantially the same as the arrangement direction of the plurality of electrodes. A plurality of optical elements.

(4) It is preferable that a plurality of electrodes and a straight line forming two areas of the two surfaces of the flexible substrate are arranged side by side substantially in parallel.

(5) Preferably, the optical signal obtaining portion is formed of a material having a higher Young's coefficient than the flexible substrate, and further includes a protective layer surrounding the optical element while contacting the optical element.

(6) Preferably, the protective layer includes: a hard layer in contact with the optical element; and a soft layer formed of a material having a lower Young's coefficient than the hard layer and adjacently contacting the hard layer.

(7) It is preferable that the electrode sheet includes a marking portion that can be aligned to a predetermined position of the biological body in order to contact the electrical signal obtaining portion and the optical signal obtaining portion to a measurement position of the biological body.

(8) Preferably, the flexible substrate is formed of a reference layer, the reference layer including: a first reference layer configured with the electrical signal acquisition section; and a second reference layer configured with the optical signal acquisition section ; Wherein the first reference layer and the second reference layer are configured to partially overlap.

(9) Preferably, the plurality of electrodes and a part of the optical element wiring connected to the optical signal acquisition section are arranged on one side of the first reference layer; the second reference layer is arranged in the thickness direction The first reference layer and the second reference layer are overlapped in a state where the plurality of electrodes are inserted into the insertion hole, and other portions of the optical element wiring formed on one surface.

(10) Preferably, the optical signal acquisition section is overlapped on one side of the second reference layer.

(11) Preferably, the optical element wiring is sandwiched in the thickness direction between the first reference layer and the second reference layer.

(12) In addition, the present invention relates to an electrode sheet module including: any one of (1) to (11); and a wireless device that is connected to the flexible substrate and can be sent out wirelessly The biomedical signal obtained by the biomedical signal acquisition department.

According to the present invention, an electrode sheet that can be easily aligned can be provided.

1‧‧‧ electrode pads

2‧‧‧ Resolution Device

10‧‧‧ Flexible substrate

11‧‧‧Biomedical Signal Acquisition Department

12‧‧‧Marking Department

13‧‧‧ ground electrode

14‧‧‧ Electrical Signal Acquisition Department

15‧‧‧Optical Signal Acquisition Department

16‧‧‧ electrode

17‧‧‧ electrode wiring

18‧‧‧ Optical Elements

19, 19C‧‧‧ protective layer

20, 20A‧‧‧Lighting Department

21‧‧‧Light receiving section

22, 22C‧‧‧hard layer

23, 23C‧‧‧ soft layer

24, 25‧‧‧ Wiring

26C‧‧‧ Overlay

31‧‧‧ support board

32‧‧‧ sacrificial layer

33‧‧‧PEN (or PET) layer

40‧‧‧ Adhesive layer

41‧‧‧The first adhesive layer

42‧‧‧ 2nd adhesive layer

50‧‧‧ insertion hole

101‧‧‧Biomedical signal acquisition area

102‧‧‧Wiring configuration area

103‧‧‧Reference layer

104‧‧‧contact layer

105‧‧‧through hole

131‧‧‧The first reference layer

132‧‧‧The second reference layer

171‧‧‧Optical element wiring

201‧‧‧Anode

202‧‧‧hole injection layer

203‧‧‧hole transport layer

204‧‧‧Light-emitting layer

205‧‧‧ electron injection layer

205A1‧‧‧ electron injection characteristic metal oxide layer

205A2‧‧‧ Electron injection characteristics organic buffer layer

206‧‧‧ cathode

207‧‧‧adhesive layer

S1, S2, S3, S4, S5, S6 ‧‧‧ steps

X, Y‧‧‧ straight

Fig. 1 is a plan view showing an electrode sheet according to a first embodiment of the present invention.

Fig. 2 is a sectional view taken along line A-A in Fig. 1;

Fig. 3 is a schematic perspective view showing a light emitting unit according to the first embodiment.

FIG. 4 is a schematic perspective view when the electrode sheet of the first embodiment is used in a living body.

Fig. 5 is a schematic perspective view showing a light emitting unit according to a second embodiment.

Fig. 6 is a plan view showing an electrode sheet according to a third embodiment.

Fig. 7 is a schematic cross-sectional view showing a process of forming an optical signal acquisition section of an electrode sheet according to a fourth embodiment.

Fig. 8 is a schematic cross-sectional view showing a process of forming an optical signal acquisition section of an electrode sheet according to a fourth embodiment.

Fig. 9 is a schematic cross-sectional view showing a process of forming an optical signal acquisition section of an electrode sheet according to a fourth embodiment.

Fig. 10 is a schematic cross-sectional view showing a process of forming an electrode sheet according to a fourth embodiment.

Fig. 11 is a schematic sectional view showing a process of forming an electrode sheet according to a fourth embodiment.

Fig. 12 is a schematic sectional view showing a process of forming an electrode sheet according to a fourth embodiment.

Fig. 13 is a schematic cross-sectional view showing a process of forming an electrode sheet according to a fourth embodiment.

Fig. 14 is a schematic sectional view showing a process of forming an electrode sheet according to a fourth embodiment.

Fig. 15 is a schematic cross-sectional view showing a process of forming an electrode sheet according to a fifth embodiment.

Fig. 16 is a schematic cross-sectional view showing a process of forming an electrode sheet according to a fifth embodiment.

Fig. 17 is a schematic sectional view showing a process of forming an electrode sheet according to a fifth embodiment.

Fig. 18 is a schematic plan view showing the arrangement of a light emitting section and a light receiving section in a modification of the present invention.

Fig. 19 is a flowchart showing a flow of analyzing a biomedical signal in a modification of the present invention.

Hereinafter, various embodiments of the electrode sheet according to the present invention will be described with reference to FIGS. 1 to 17. In addition, each embodiment described below is exemplified, and an embodiment in which other embodiments are added to the description of each embodiment, and an embodiment that replaces the description of each embodiment is an embodiment of the present invention.

The electrode sheet 1 according to each embodiment is a person who is attached to, for example, a forehead of a human body to obtain a biomedical signal. Examples of biomedical signals include signals sent spontaneously, such as brain waves and heartbeats, as well as signals obtained by penetration or reflection of irradiated light. In order to effectively obtain these biomedical signals on the forehead of the human body, the electrode sheet 1 as a whole preferably has elasticity and flexibility. The electrode sheet 1 can be bent following the curved shape of the forehead. Therefore, the electrode sheet 1 can be closely attached to, for example, a forehead, and a biomedical signal can be continuously obtained.

In particular, the electrode sheet 1 according to each embodiment can obtain two kinds of biomedical signals at the same time. For example, according to the electrode sheet 1 of each implementation type, two kinds of biomedical signals including brain wave and blood oxygen saturation can be obtained at the same time among the biomedical signals. In this way, the electrode pad 1 according to each embodiment can obtain blood oxygen saturation based on blood oxygen saturation, and is helpful for analyzing the biomedical signals of the brain wave.

[First embodiment]

Next, an electrode sheet 1 according to a first embodiment of the present invention will be described with reference to FIGS. 1 to 4.

The electrode sheet 1 according to this embodiment includes a flexible substrate 10, a biomedical signal acquisition unit 11, a labeling unit 12, and a ground electrode 13 as shown in Figs. 1 to 4. The electrode sheet 1 is formed in a substantially rectangular shape as a whole. The electrode sheet 1 is formed in a size that can be attached to the forehead of a living body (human body). Specifically, the electrode sheet 1 obtains a signal for blood oxygen saturation near two eyes in the forehead. In addition, the electrode sheet 1 acquires an electroencephalogram before the forehead above it.

The flexible substrate 10 has a rectangular shape in a plan view. One side of the flexible substrate 10 has a shape protruding in an out-of-plane direction. Specifically, the flexible substrate 10 has a biomedical signal acquisition area 101 formed in a rectangular shape on one side of the straight line X in FIG. 1, and a rectangular region on the other side of the straight line X that protrudes out of the plane. Shaped wiring arrangement area 102. The flexible substrate 10 can be connected to an external analysis device 2 at the wiring arrangement area 102, or a wireless device (not shown) that sends a biomedical signal to the analysis device 2 via wireless. A plurality of wirings 25, 25, ... are arranged in the wiring arrangement area 102. Such a flexible substrate 10 includes a reference layer 103 and a contact layer 104. In addition, a wireless device (not shown) and the electrode sheet 1 connected to the flexible substrate 10 constitute an electrode sheet module.

The reference layer 103 is disposed on the entire area of the flexible substrate 10 combining the biomedical signal acquisition area 101 and the wiring arrangement area 102. The reference layer 103 is formed in a sheet shape. The reference layer 103 is formed of a material having flexibility and stretchability. The reference layer 103 forms a surface exposed when the electrode sheet 1 is mounted on the forehead.

The contact layer 104 forms a surface that contacts the forehead when the electrode sheet 1 is mounted on the forehead. The contact layer 104 is formed in a sheet shape like the reference layer 103. Like the reference layer 103, the contact layer 104 is formed of a material having flexibility and stretchability. The contact layer 104 is formed to overlap the reference layer 103. In particular, the contact layer 104 is formed to cover the entire surface of the reference layer 103 with the same shape and size as the shape of the reference layer 103. Then, at the biomedical signal acquisition area 101, the contact layer 104 has a through hole 105 in another area defined by the straight line Y. Specifically, at the biomedical signal acquisition area 101, the contact layer 104 has a through-hole 105 in a region defined by the straight line Y in a region close to both eyes. In this embodiment, the contact layer 104 has four through holes 105 formed at a predetermined interval along the straight line Y. The straight line Y is a virtual straight line.

The biomedical signal acquisition unit 11 is arranged on the flexible substrate 10 and obtains a biomedical signal of a living body. Specifically, the biomedical signal acquisition unit 11 obtains two kinds of biomedical signals. Such a biomedical signal acquisition unit 11 includes an electrical signal acquisition unit 14 and an optical signal acquisition unit 15.

The electric signal acquisition unit 14 is arranged in a region (a region contacting the upper part of the forehead) of one surface of the flexible substrate 10 divided by the straight line Y. The electrical signal acquisition unit 14 can acquire a biomedical signal electrically. Such an electrical signal acquisition unit 14 includes a plurality of electrodes 16, 16, ..., and a plurality of electrode wirings 17, 17, .... The entire electrical signal acquisition section 14 is formed on one surface of the flexible substrate 10 by a printing method. In this embodiment, the electrical signal acquisition unit 14 is disposed in a region divided by a straight line Y along the long side of the flexible substrate 10.

The plurality of electrodes 16, 16,... Are arranged side by side in a predetermined direction along the surface of the flexible substrate 10. In this embodiment, the plurality of electrodes 16, 16, ... are arranged side by side along one side (long side) of a rectangular shape formed in a plan view.

In addition, the plurality of electrodes 16, 16,... And the straight line Y forming two regions divided by one surface of the flexible substrate 10 are arranged substantially in parallel. Then, each electrode 16 is arranged to be alternately displaced relative to the adjacent electrode 16 in a direction perpendicular to the side-by-side direction. As a result, the plurality of electrodes 16, 16,... Can be arranged at various positions in the area of the electric signal acquisition unit 14, rather than the plurality of electrodes 16, 16,. Therefore, it is possible to obtain more accurate data of biomedical signals. Regardless of where the biomedical signals are sent with individual differences, the plurality of electrodes 16, 16, ... can obtain the biomedical signals in any of them.

The plurality of electrode wirings 17, 17,... Are provided to match the number of the plurality of electrodes 16. The plurality of electrode wirings 17, 17,... Are provided to extend from the protruding edge of the flexible substrate 10 to the flexible substrate 10 and are connected to the plurality of electrodes 16, respectively. In addition, a plurality of electrode wirings 17, 17,... May be connected to the analysis device 2 as the wirings 25, 25,... Of the wiring arrangement area 102.

According to the electrical signal acquisition unit 14 described above, by attaching the plurality of electrodes 16, 16, ... to the measurement position of the biomedical signal, the biomedical signal sent spontaneously by a brain wave or the like can be used as the electrical signal Get. The plurality of electrodes 16 can transmit the obtained electrical signals to the analysis device 2 and the like through the plurality of electrode wirings 17, 17, ....

The optical signal acquisition section 15 is disposed on one surface of the flexible substrate 10 in the same manner as the electrical signal acquisition section 14. Then, the optical signal acquisition unit 15 is disposed in another area (a position close to both eyes in the forehead) of the one surface of the flexible substrate 10 which is bisected by the straight line Y. The optical signal acquisition unit 15 obtains a signal obtained based on the irradiated light by irradiating the living body with light. Such an optical signal acquisition unit 15 includes a plurality of optical elements 18, 18,... And a protective layer 19. In this embodiment, the optical signal acquisition unit 15 is a pair of optical elements 18 and a protective layer 19 provided in a region surrounded by the inner surface of each through hole 105. In addition, in the present embodiment, the optical signal acquisition unit 15 is disposed in another region divided by a straight line Y along the long side of the flexible substrate 10.

The plurality of optical elements 18, 18,... Are arranged side by side in substantially the same direction as the arrangement direction of the plurality of electrodes 16. In other words, a plurality of optical elements 18, 18,... And a straight line forming two regions of one surface of the flexible substrate 10 bisecting are arranged side by side approximately in parallel. Each of the plurality of optical elements 18, 18,... Includes a light emitting section 20 and a light receiving section 21 as shown in FIG. 1. Each of the plurality of optical elements 18, 18,... Is connected to a wiring (not shown) formed on the flexible substrate 10.

The light emitting section 20 is, for example, an OLED (Organic EL Diode), an iOLED (Reverse Organic EL Diode), or a general LED, and is provided to irradiate a living body with light of a predetermined wavelength. In this embodiment, the light emitting section 20 is an OLED. The light emitting section 20 is configured by stacking a plurality of layers. Specifically, as shown in FIG. 3, the light emitting section 20 includes an anode 201, a hole injection layer 202, a hole transport layer 203, a light emitting layer 204, an electron injection layer 205, and a cathode 206. Then, the light emitting section 20 is laminated in this order in the order of the anode 201, the hole injection layer 202, the hole transport layer 203, the light emitting layer 204, the electron injection layer 205, and the cathode 206. The light emitting section 20 radiates light to the outside in a direction from the cathode 206 to the anode 201.

As an example, the light emitting section 20 is produced in the following manner.

[1] A commercially available PET (polyethylene terephthalate) substrate with an ITO electrode layer having an average thickness of 0.1 mm was prepared. At this time, the ITO electrode (anode 201) of the substrate is a one having a pattern width of 1 mm. This substrate was ultrasonically cleaned in isopropyl alcohol for 10 minutes. This substrate was taken out of isopropyl alcohol, dried with a nitrogen blow, and then subjected to UV ozone cleaning for 20 minutes.

[2] This substrate was set to a spin coater, and a commercially available aqueous dispersion of poly (3,4-ethylenedioxythiophene / styrene sulfonic acid) (PEDOT / PSS) was dropped. , And rotated at 1800 revolutions per minute for 60 seconds, and further dried by a hot plate at 125 ° C. for 10 minutes to form a hole injection layer 202 composed of PEDOT / PSS on the anode. The average thickness of the hole injection layer 202 is 60 nm. The average thickness of the hole injection layer 202 is measured by a step profiler.

[3] The substrate formed until the hole injection layer 202 is fixed to a substrate holder of a vacuum evaporation apparatus. 4,4'-bis (9-dicarbazolyl) -2,2'-biphenyl (4,4'-bis (9-dicarbazolyl) -2,2'-biphenyl (CBP)) and tris (1 -Phenylisoquinoline) iridium (III) (tris (1-phenylisoquinoline) iridium (III), Ir (piq) 3), N, N'-bis (1-naphthalene) -N, N'-diphenyl- 1,1'-biphenyl-4,4'-diamine (N, N'-di (1-naphthyl) -N, N'-diphenyl-1,1'-biphenyl-4,4'-diamine, α -NPD) was put into an alumina crucible to set as a vapor deposition source. The inside of the vacuum evaporation device was depressurized to about 1 x 10-5 Pa, and α-NPD was evaporated at 60 nm to deposit a hole transporting layer 203. Next, 35 nm was deposited by using CBP as the host and Ir (piq) 3 as the dopant to deposit a light-emitting layer 204. At this time, the dopant concentration Ir (piq) 3 is 6% by weight based on the entire light emitting layer 204.

[4] A mixed ethanol solution of commercially available polyethylenimine SP-200 and triphenylphosphine oxide manufactured by Nippon Shokubai is produced. At this time, the concentration of triphenylphosphine oxide was 0.5%, and the concentration of polyethyleneimine oxide was 1%. The substrate prepared in the above procedure [4] was set to a spin coater. A polyethyleneimine-triphenylphosphine oxide mixed ethanol solution was dropped on the light-emitting layer 204 formed in the above procedure [3], and rotated at 2000 revolutions per minute for 30 seconds to form an electron injection layer 205 on the light-emitting layer 204. The average thickness of the electron injection layer 205 is 10 nm. The average thickness of the electron injection layer 205 is measured by a probe-type step measurement.

[5] Fix the substrate produced in the above procedure [4] to a substrate holder. An aluminum wire (Al) was put into an aluminum-oxygen crucible to be used as a vapor deposition source. The pressure in the vacuum evaporation device was reduced to about 1 × 10-4 Pa, and Al (cathode 206) was vapor-deposited on the electron injection layer 205 to have an average thickness of 100 nm to produce an organic electroluminescent device (1). The average thickness of the cathode 206 is measured by a crystal oscillating film thickness meter during deposition. When the cathode 206 was vapor-deposited, a vapor deposition mask made of stainless steel was used so that the vapor-deposited surface had a strip shape with a width of 1 mm. That is, the light-emitting area of the produced organic electroluminescent device was 1 mm ² .

The light receiving section 21 is, for example, a PD (photodiode) or an OPD (organic photodiode). The light receiving section 21 and the light emitting section 20 are provided in pairs. The light receiving section 21 is configured to receive reflected light from the light emitted from the light emitting section 20. In this embodiment, the light receiving section 21 is arranged adjacent to the light receiving section 21 in a direction perpendicular to the side-by-side direction of the plurality of optical elements 18, 18,.... The light-receiving unit 21 can be configured and manufactured as described in "8.9% Single-Stack Inverted Polymer Solar Cells with Electron-Rich Polymer Nanolayer-Modified Inorganic Electron-Collecting Buffer Layers (ADVANCED ENERGY MATERIALS, published on January 7, 2014)". Production.

As shown in FIG. 1 and FIG. 2, the protective layer 19 is a layer having a flexibility layered on the reference layer 103. The protective layer 19 is formed of a material having a higher Young's coefficient than the contact layer 104. The protective layer 19 contacts the optical element 18 while surrounding the optical element 18. The protective layer 19 has the same stretchability as the flexible substrate 10. In the present embodiment, the protective layer 19 is formed in a size corresponding to the area formed by the optical signal acquisition section 15 in the flexible substrate 10. Such a protective layer 19 includes a hard layer 22 and a soft layer 23. The protective layer 19 is formed of a material that transmits the wavelength of the light irradiated by the light emitting portion 20 and the wavelength of the light acceptable to the light receiving portion 21.

The hard layer 22 is formed of a material having a higher Young's coefficient than the contact layer 104. The hard layer 22 is formed with a diameter smaller than the diameter of the through hole 105. The hard layer 22 is in contact with the optical element 18. Then, the hard layer 22 is laminated on the reference layer 103 to seal each of the plurality of optical elements 18, 18,... In other words, the hard layer 22 is formed to seal the light emitting portion 20 and the light receiving portion 21 between the hard layer 22 and the reference layer 103.

The soft layer 23 is formed of a material having a lower Young's coefficient than the hard layer 22. The soft layer 23 is in contact with the hard layer 22 adjacently. That is, the soft layer 23 is configured to fill a portion between the hard layer 22 and the contact layer 104. In addition, the exposed surface layer of the soft layer 23 is completely flush with the exposed surface of the hard layer 22.

According to the optical signal acquisition unit 15 described above, when mounted on a living body, the protective layer 19 is bent along the bending of the living body. At this time, the soft layer 23 having a low Young's coefficient is easier to bend, and the hard layer 22 having a high Young's coefficient is difficult to bend. Therefore, even if the soft layer 23 is relatively curved, the hard layer 22 is not more curved than the soft layer 23, and the deformation caused by the bending can be suppressed from being transmitted to the optical element 18. Thereby, damage to the optical element 18 due to bending can be suppressed.

Then, according to the electrical signal acquisition section 14 and the optical signal acquisition section 15 described above, since the plurality of electrodes 16, 16,... And the plurality of optical elements 18, 18,... Are provided on the flexible substrate 10. On the same side (one side), a plurality of electrodes 16, 16, ... and a plurality of optical elements 18, 18, ... can be brought into contact with a living body at the same time. In this way, both the electrical student medical signal and the optical student medical signal can be obtained at the same time.

In order to contact the electrical signal acquisition section 14 and the optical signal acquisition section 15 to the measurement position of the living body, the marking section 12 is arranged to be aligned to a predetermined position of the living body. In this embodiment, as shown in FIG. 4, the indicator portion 12 is provided on a surface opposite to one surface of the flexible substrate 10 (the surface exposed when the electrode sheet 1 is attached to a living body, hereinafter referred to as Exposed surface). In other words, the indicator 12 is disposed on the reference layer 103. For example, the indicator portion 12 is provided as a straight line on a surface opposite to one surface of the flexible substrate 10 by printing or the like so as to be aligned with the nose bridge direction.

The ground electrode 13 (not shown in FIG. 4) is connected to the wiring 25 in the wiring arrangement area 102 through the wiring 24. The ground electrode 13 is provided so as to be in contact with an ear of a living body or the like for obtaining a reference potential of the living body. The ground electrode 13 can be connected to the analysis device 2 through the wiring 24 and the wiring 25.

The electrode sheet 1 described above is used as described below.

First, the electrode sheet 1 approaches a measurement position of a living body. At this time, the surface (one surface of the reference layer 103) on which the indicator portion 12 is provided is an exposed surface. Then, the indicator portion 12 is aligned to a predetermined position (for example, a position along the bridge of the nose) of the living body. In a state in which the indicator portions 12 are aligned, the electrode sheet 1 is attached to a living body.

By attaching the electrode sheet 1 to a living body, the flexible substrate 10 and the protective layer 19 are bent along the bending of the living body. For example, by attaching the electrode sheet 1 to the forehead of the living body, the flexible substrate 10 and the protective layer 19 are bent along the shape of the forehead. Thereby, the plurality of electrodes 16, 16, ... can obtain a biomedical signal (electrical signal) from the living body through contact with the living body. In addition, the plurality of optical elements 18, 18, ... can irradiate and receive light to a living body, and can obtain a biomedical signal (optical signal) from the living body.

Specifically, the light emitting unit 20 irradiates a blood vessel with a single light or a plurality of lights having different wavelengths. As a result, hemoglobin in the blood absorbs light. The light that has not been absorbed is collected by the light receiving unit 21. It is known that the amount of light absorption of hemoglobin differs between an oxidized state and a reduced state. Therefore, the ratio of oxidized hemoglobin can be calculated from the magnitude of the received reflected wave. This is called blood oxygen saturation (SpO2).

Here, the ground electrode 13 is attached to an ear of a living body or the like, and can obtain a reference potential of the living body. As a result, the electrode sheet 1 can obtain a biological signal relative to a reference potential.

According to the electrode sheet 1 of the first embodiment described above, the following effects are achieved.

(1) The electrode sheet 1 includes: a sheet-shaped flexible substrate 10; and a biomedical signal acquisition unit 11 arranged on the flexible substrate 10 and obtaining a biomedical signal of a living body. Then, the biomedical signal acquisition unit 11 includes: an electric signal acquisition unit 14 arranged on the flexible substrate 10 and capable of obtaining the biomedical signal electrically; and disposed on the flexible substrate 10 and obtained by irradiating light to a living body. A plurality of optical signal acquisition sections 15 of a biomedical signal obtained based on the irradiated light. This makes it possible to provide the electrode sheet 1 which is bent in accordance with the unevenness of the living body. Then, the electrical signal acquisition unit 14 acquires electrical biomedical signals such as brain waves, and can obtain percutaneous arterial oxygen saturation (SpO2) and the like as optical student medical signals. In this way, it is possible to provide an electrode sheet 1 that can simultaneously obtain a plurality of biomedical signals with a simple structure.

(2) The electrical signal acquisition unit 14 is disposed in a region of one surface of the flexible substrate 10 bisecting the straight line Y. The optical signal acquisition section 15 is arranged in another area. Thereby, each of the electrical signal acquisition section 14 and the optical signal acquisition section 15 can be easily aligned with the measurement position of the living body.

(3) The electrical signal acquisition section 14 includes a plurality of electrodes 16, 16, ... arranged side by side in a predetermined direction along the surface of the flexible substrate 10. In addition, the optical signal acquisition unit 15 includes a plurality of optical elements 18, 18,... Arranged side by side substantially parallel to the arrangement direction of the plurality of electrodes 16, 16,.... Thereby, since the plurality of electrodes 16, 16, ... and the plurality of optical elements 18, 18, ... which are arranged side by side in a predetermined direction contact the measurement position of the living body, a biomedical signal can be obtained more reliably.

(4) The plurality of electrodes 16, 16,... And the straight line Y forming two regions divided by one surface of the flexible substrate 10 are arranged side by side approximately in parallel. Thereby, since the extension directions of the respective areas of the electrical signal acquisition section 14 and the optical signal acquisition section 15 are aligned with the arrangement of the plurality of electrodes 16, 16, ..., and the plurality of optical elements 18, 18, ... Ground position both relative to the organism.

(5) The optical signal acquisition section 15 is formed of a material harder than the flexible substrate 10, and further includes a protective layer 19 surrounding the optical element 18 while coming into contact with the optical element 18. Accordingly, the deformation caused to the optical element 18 due to the bending of the flexible substrate 10 can be reduced through the protective layer 19. Therefore, the optical element 18 can be protected from deformation.

(6) The protective layer 19 includes a hard layer 22 in contact with the optical element 18 and a soft layer 23 formed of a material having a lower Young's coefficient than the hard layer 22 and adjacently contacting the hard layer 22. Accordingly, since the deformation applied to the optical element 18 can be reduced through the hard layer 22 and the soft layer 23, the optical element 18 can be more protected from deformation.

(7) In order to contact the electrical signal acquisition section 14 and the optical signal acquisition section 15 to the measurement position of the living body, the electrode sheet 1 further includes a marking section 12 that can be aligned with a predetermined position of the living body. Therefore, by aligning the marking portion 12 to a predetermined position of the living body, the electrical signal obtaining portion 14 and the optical signal obtaining portion 15 can be brought into contact with the measurement position of the living body. Therefore, manipulation of the electrode sheet 1 can be performed more easily.

In addition, since the electrodes 16 and the optical elements 18 can be contacted closer to the place where the biomedical signal can be obtained, the number of the electrodes 16 and the optical elements 18 can be reduced compared with the case where the marking portion 12 is not provided, and the The manufacturing cost of the electrode sheet 1 is reduced.

(8) The electrode sheet module includes: an electrode sheet 1; and a wireless device connected to the flexible substrate 10 and capable of transmitting the biomedical signal obtained by the biomedical signal acquisition section 11 wirelessly. Therefore, compared with the case of using a wired device to send a birth medical signal, the measurement of a biomedical signal can be performed simply and with a high degree of freedom. In addition, the S / N ratio (biomedical signal to noise ratio) is improved.

[Second embodiment]

Next, an electrode sheet 1 according to a second embodiment of the present invention will be described with reference to FIG. 5. In the description of the second embodiment, the same constituent elements are denoted by the same reference numerals, and their description is omitted or simplified.

The electrode sheet 1 according to the second embodiment differs from the first embodiment in that the light emitting section 20A is replaced with an iOLED (inverted organic EL diode).

The light-emitting portion 20A, like the light-emitting portion 20, includes a plurality of layers. In addition, as shown in FIG. 5, the light emitting section 20A includes the cathode 206, an electron injection characteristic metal oxide layer 205A 1, an electron injection characteristic organic buffer layer 205A 2, a light emitting layer 204, an electric transport layer 203, The hole injection layer 202 and the anode 201. The layers of the light emitting section 20A are laminated in the reverse order of the light emitting section 20. The light emitting section 20A, as opposed to the light emitting section 20, radiates light to the outside in a direction from the anode 201 to the cathode 206.

Next, a method of manufacturing the light emitting section 20A will be described below. In addition, in the following production method, the average thickness of the buffer layer was measured with a probe type step meter (product name "Alpha-Step IQ", manufactured by KLA-Tencor).

[1] A commercially available PET substrate with an ITO electrode layer having an average thickness of 0.1 mm was prepared. At this time, the ITO electrode (cathode 206) of the substrate was patterned to a width of 1 mm. This substrate was ultrasonically cleaned in isopropyl alcohol for 10 minutes. This substrate was taken out of isopropyl alcohol, dried with a nitrogen gas stream, and UV-ozone-washed for 20 minutes.

[2] This substrate is fixed to a substrate holder of a mirrortron sputtering device holding a zinc metal target. After reducing the pressure to about 1 × 10-4Pa, sputtering was performed while introducing argon and oxygen to establish a zinc oxide layer having a film thickness of about 2 nm. At this time, a metal mask is used together so that a part of the ITO electrode is free from zinc oxide deposition for electrode extraction.

[3] Prepare a 1% water-ethanol (volume ratio 1: 3) mixed solution of magnesium acetate. The substrate produced in the procedure [2] was cleaned again in the same manner as in the procedure [1]. The cleaned substrate with the zinc oxide film was set to a spin coater. A magnesium acetate solution was dropped on this substrate and rotated at 1300 revolutions per minute for 60 seconds. This was sintered for 2 hours with a hot plate set at 100 ° C in the atmosphere to form a zinc oxide / magnesium oxide layer (electron injection characteristic metal oxide layer 205A1).

[4] Preparation of a commercially available ethanol solution of polyethyleneimine SP-200 manufactured by Nippon Catalysts. At this time, the concentration of polyethyleneimine was 0.4%. The substrate prepared in the above procedure [3] was set to a spin coater. A polyethyleneimine ethanol solution was dropped on the layer formed by the above procedure [3] and rotated at 2000 revolutions per minute for 30 seconds to form an electron injection characteristic organic buffer layer 205A2 on the electron injection characteristic metal oxide layer 205A1. The average thickness of the electron injection characteristic organic buffer layer 205A2 was 10 nm. Electron injection characteristics The average thickness of the organic buffer layer 205A2 is measured by a probe-type step measurement.

[5] The substrate formed up to the procedure [4] is fixed to a substrate holder of a vacuum evaporation apparatus. 4,4'-bis (9-dicarbazolyl) -2,2'-biphenyl (4,4'-bis (9-dicarbazolyl) -2,2'-biphenyl (CBP)) and tris (1 -Phenylisoquinoline) iridium (III) (tris (1-phenylisoquinoline) iridium (III), Ir (piq) 3), N, N'-bis (1-naphthalene) -N, N'-diphenyl- 1,1'-biphenyl-4,4'-diamine (N, N'-di (1-naphthyl) -N, N'-diphenyl-1,1'-biphenyl-4,4'-diamine, α -NPD) was put into an aluminum-oxygen crucible to set as an evaporation source. The vacuum evaporation device was decompressed to about 1 × 10-5 Pa, and CBP was used as the main body and Ir (piq) 3 was used as the dopant to co-evaporate 35 nm to deposit a light-emitting layer 204. At this time, the dopant concentration Ir (piq) 3 is 6% by weight based on the entire light emitting layer 204. Next, α-NPD was deposited at 60 nm to deposit a hole transporting layer 203. Next, after purging with nitrogen, molybdenum trioxide and gold were placed in an aluminum-oxygen crucible to set a vapor deposition source. The inside of the vacuum evaporation device was decompressed to about 1 × 10-5 Pa, and molybdenum trioxide (hole injection layer 202) was vapor-deposited to a film thickness of 10 nm. Next, gold (anode 201) was vapor-deposited to have a film thickness of 50 nm, and an organic electroluminescent device 1 was produced. When gold was vapor-deposited, a stainless steel vapor-deposition mask was used so that the vapor-deposited surface had a strip shape with a width of 1 mm. That is, the light-emitting area of the produced organic electroluminescent device was 1 mm ² .

According to the electrode sheet 1 of the second embodiment described above, in addition to the effects (1) to (8) described above, the following effects can be achieved.

(9) The light emitting section 20A is made of iOLED. As a result, the light emitting unit 20A can have higher atmospheric stability than a OLED structure, and stable measurement can be achieved.

[Third embodiment]

Next, an electrode sheet 1 according to a third embodiment of the present invention will be described with reference to FIG. 6. In the description of the third embodiment, the same constituent elements are denoted by the same symbols to omit or simplify the description.

As shown in FIG. 6, the electrode sheet 1 according to the third embodiment differs from the first embodiment and the second embodiment in that an adhesive layer 40 is included on the surface attached to the living body. .

The adhesive layer 40 is arranged so as to be exposed on the surface attached to the living body. That is, the adhesive layer 40 is configured to be accessible to a living body that obtains a biomedical signal. The adhesive layer 40 fixes the plurality of electrodes 16, 16,... And the plurality of optical elements 18, 18,... To the living body by contacting the living body. The adhesive layer 40 includes a first adhesive layer 41 and a second adhesive layer 42.

The first adhesive layer 41 is arranged so as to be superposed on each of the plurality of electrodes 16, 16,.... The first adhesive layer 41 transmits a biomedical signal to the electrode 16 by being in contact with a living body. The first adhesive layer 41 is preferably composed mainly of a gel such as an acrylic gel, a urethane gel, or a silicone gel. In order to obtain a biomedical signal, the first adhesive layer 41 contains electrolyte salts such as sodium chloride and potassium chloride. Specific examples include "Technogel CR" and "Technogel G" manufactured by Sekisui Plastics Co., Ltd. Examples of the method of disposing the first adhesive layer 41 on the electrode 16 include a method of applying and printing a gel, a method of cutting a sheet-like gel into an electrode shape, and attaching the same.

The second adhesive layer 42 is disposed in another area defined by the straight line Y. Specifically, the second adhesive layer 42 is arranged so as to overlap the exposed surface of the contact layer 104 in another area defined by the straight line Y. The second adhesive layer 42 is preferably arranged only on the exposed surface of the contact layer 104 and does not overlap the optical element 18. Accordingly, since the second adhesive layer 42 does not block the light irradiated from the optical element 18, a more accurate optical signal can be obtained. In addition, the second adhesive layer 42 is more preferably disposed on a part of the exposed surface of the contact layer 104. Thereby, it is possible to suppress the vapor caused by the second adhesive layer 42 being attached to the living body, and to prevent foreign matter such as sweat from entering between the optical element and the living body. As the second adhesive layer 42, for example, acrylic, urethane-based, and silicone-based double-sided adhesive tapes “No. 9874”, “No. 1522”, and “No. 1513” can be used. In addition to the second adhesive layer 42, by providing a hole (not shown) penetrating in the thickness direction of the flexible substrate 10, vapor can be suppressed. The second adhesive layer 42 may be plurally arranged at intervals along the straight line Y. Thereby, a portion where the second adhesive layer 42 is not provided is used as a vent hole, and steam can be suppressed.

According to the electrode sheet 1 of the third embodiment described above,

The effects (1) to (9) also achieve the effects described below.

(10) The electrode sheet 1 further includes an adhesive layer 40 for fixing a plurality of electrodes 16, 16, ..., and a plurality of optical elements 18, 18, ... to a living body. Thereby, the plurality of electrodes 16, 16, ..., and the plurality of optical elements 18, 18, ... can be fixed to the living body, and a biomedical signal can be appropriately obtained.

(11) The adhesive layer 40 includes a first adhesive layer 41 and a second adhesive layer 42. The second adhesive layer 42 is disposed so as not to overlap the optical element 18. Accordingly, since the second adhesive layer 42 does not block the light irradiated from the optical element 18, a biomedical signal can be appropriately obtained.

(12) The second adhesive layer 42 is disposed on a part of the exposed surface of the contact layer 104. It can suppress the vapor caused by the second adhesive layer 42 from being attached to the living body, and can prevent foreign matter such as sweat from entering between the optical element 18 and the living body. Therefore, a biomedical signal can be appropriately obtained.

[Fourth embodiment]

Next, an electrode sheet 1 according to a fourth embodiment of the present invention will be described with reference to FIGS. 7 to 14. In the description of the fourth embodiment, the same constituent elements are denoted by the same symbols to omit or simplify the description. In FIGS. 13 and 14, the light signal acquisition unit 15 is omitted for the sake of simplicity.

The electrode sheet 1 according to the fourth embodiment differs from the first to third embodiments in that the flexible substrate 10 is formed of the reference layer 103 and does not include the contact layer 104. The electrode sheet 1 according to the fourth embodiment differs from the first to third embodiments in that the reference layer 103 includes a first reference layer 131 and a second reference layer 132. The electrode sheet 1 according to the fourth embodiment is different from the first to third embodiments in that it includes a cover layer 26C. The electrode sheet 1 according to the fourth embodiment differs from the first to third embodiments in that the optical element wiring 171 is formed in the optical signal acquisition section 15 and a cover layer including a replacement contact layer 104. 26C. Then, the electrode sheet 1 according to the fourth embodiment differs from the first to third embodiments in that the optical signal acquisition section 15 is disposed on the exposed surface of the reference layer 103.

The first reference layer 131 is formed of, for example, polyurethane. The first reference layer 131 is disposed in a region defined by a straight line Y. That is, the first reference layer 131 is disposed in a region where the electric signal acquisition unit 14 is disposed. A plurality of electrodes 16, 16,... Are arranged on one surface of the first reference layer 131. A first adhesive layer 41 is arranged on the surface of the plurality of electrodes 16, 16,.... A part of the optical element wiring 171 is disposed on one surface of the first reference layer 131.

The second reference layer 132 is formed of a material having light permeability. Like the first reference layer 131, the second reference layer 132 is formed of, for example, polyurethane. The second reference layer 132 is arranged throughout the biomedical signal acquisition area 101. That is, the second reference layer 132 is disposed in a region where the electrical signal acquisition section 14 and the optical signal acquisition section 15 are disposed. In other words, the second reference layer 132 is disposed so as to overlap the first reference layer 131. In addition, among the surfaces of the second reference layer 132 that are overlapped with the first reference layer 131, an optical signal acquisition section 15 connected to other portions of the optical element wiring 171 is disposed. In addition, a plurality of insertion holes 50 are formed in the second reference layer 132 and penetrate through the thickness direction. A second adhesive layer 42 is disposed on the other surface of the second reference layer 132. The first reference layer 131 and the second reference layer 132 are arranged so as to overlap with each other.

The insertion holes 50 are arranged and formed to coincide with the arrangement positions of the plurality of electrodes 16, 16, ... in the in-plane direction of the second reference layer 132. Each of the insertion holes 50 exposes the electrode 16 inserted into the opening on one surface side from the opening on the other surface side.

The optical signal acquisition section 15 is disposed on the exposed surface of the flexible substrate 10. The optical signal acquisition section 15 includes a protective layer 19C. The protective layer 19C includes a hard layer 22C and a soft layer 23C.

The hard layer 22C is formed in a dome shape. The hard layer 22C is disposed so as to cover each of the light emitting section 20 and the light receiving section 21. In other words, the hard layer 22C is disposed so as to be superposed on each of the light emitting section 20 and the light receiving section 21.

The soft layer 23C is formed in a dome shape. The soft layer 23C is configured to cover the hard layer 22C. In other words, the soft layer 23C is arranged to overlap the hard layer 22C.

The cover layer 26C is disposed so as to integrate the light-emitting portion 20 and the light-receiving portion 21, and covers the soft layer 23C covering the light-emitting portion 20 and the light-receiving portion 21. The cover layer 26C is preferably softer than the soft layer 23C. The cover layer 26C is formed of, for example, urethane acrylate. The cover layer 26C is formed in a sheet shape, for example.

The optical signal acquisition unit 15 and the like are produced in the following manner.

As shown in FIG. 7, a sacrificial layer 32 is formed on one surface of a support plate 31 made of glass, for example. In addition, a PEN (polyethylene naphthalate) or PET (polyethylene terephthalate) layer 33 is formed on the sacrificial layer 32. A light emitting section 20 and a light receiving section 21 are formed in parallel on the PEN (or PET) layer 33. In addition, in this embodiment, the light-emitting portion 20 and the light-receiving portion 21 are covered with an adhesive layer 207 formed of PET having a thickness of 10 m, and the outer peripheral surface is covered.

Next, as shown in FIG. 8, the portion of the PEN (or PET) layer 33 that is not overlapped with the light emitting portion 20 and the light receiving portion 21 by laser peeling. At this time, although not shown in the figure, the upper electrode and the lower electrode on the PEN (or PET) layer 33 formed on the sacrificial layer 32 are formed by printing. Next, as shown in FIG. 9, a dome-shaped hard layer 22C is formed so as to cover the light emitting section 20 and the light receiving section 21. A dome-shaped soft layer 23C is formed so as to cover the hard layer 22C. Then, a cover layer 26C is formed so as to cover the soft layer 23C. Thereafter, the support plate 31 is removed to form an optical signal acquisition unit 15 and the like.

Next, a method for producing the electrode sheet 1 using the produced optical signal acquisition section 15 will be described below.

As shown in FIG. 10, a part of the optical element wiring 171 and a plurality of electrodes 16 are formed on one surface of the first reference layer 131 by printing. In addition, other portions of the optical element wiring 171 are formed on one surface of the second reference layer 132. Then, a second adhesive layer 42 is formed on the other surface of the second reference layer 132.

Next, as shown in FIG. 11, the first reference layer 131 is overlapped with the second reference layer 132. Specifically, one surface of the first reference layer 131 overlaps with one surface of the second reference layer 132. In addition, the electrode 16 formed on one surface of the first reference layer 131 is aligned with the insertion hole 50 formed on one surface of the second reference layer 132 and inserted. As a result, a part of the optical element wiring 171 formed on one surface of the first reference layer 131 overlaps with another part of the optical element wiring 171 formed on one surface of the second reference layer 132. That is, the optical element wiring 171 is sandwiched in the thickness direction between the first reference layer 131 and the second reference layer 132. Then, the first reference layer 131 and the second reference layer 132 are thermocompression bonded. Thereby, as shown in FIG. 12, the first reference layer 131 and the second reference layer 132 are integrated.

Next, as shown in FIG. 13, the light emitting section 20 and the light receiving section 21 of the optical signal acquisition section 15 are aligned on the other optical element wirings 171 formed on one surface of the second reference layer 132. Then, the optical signal acquisition section 15 and the cover layer 26C are overlapped to the integrated first reference layer 131 and the second reference layer 132. In addition, the optical signal acquisition unit 15 is thermally bonded to the first reference layer 131 and the second reference layer 132. Thereby, as shown in FIG. 14, the optical signal acquisition unit 15 is integrated with the first reference layer 131 and the second reference layer 132.

According to the electrode sheet 1 of the fourth embodiment described above, in addition to the effects (1) to (12) described above, the following effects can be achieved.

(13) The optical signal acquisition unit 15 is disposed on the exposed side of the reference layer 103. Accordingly, the optical signal acquisition unit 15 is not affected by the sweat of the living body and the like. Therefore, the stability of the electrode sheet 1 can be improved.

(13) The reference layer 103 includes a first reference layer 131 and a second reference layer 132. The optical element wiring 171 is formed between the first reference layer 131 and the second reference layer 132 which are overlapped. Thereby, the optical element wiring 171 can be easily formed.

[Fifth embodiment]

Next, an electrode sheet 1 according to a fifth embodiment of the present invention will be described with reference to FIGS. 15 to 17. In the description of the fifth embodiment, the same constituent elements are denoted by the same symbols to omit or simplify the description. The electrode sheet 1 according to the fifth embodiment is different from the fourth embodiment in that an optical element wiring 171 and an electrode 16 are formed on the optical signal acquisition section 15.

As shown in FIGS. 15 and 16, the optical element wiring 171 and the electrode 16 are formed by printing on one surface of the cover layer 26C. Specifically, the optical element wiring 171 is formed on one surface of the cover layer 26C by printing so as to be connected to the light emitting section 20 and the light receiving section 21. Next, as shown in FIG. 17, the first adhesive layer 41 is formed on the exposed surface of the electrode 16 by printing. The second reference layer 132 is disposed so as to be overlapped on one surface of the cover layer 26C and the surface of the optical element wiring 171. That is, the second reference layer 132 is disposed so as to overlap the cover layer 26C and the optical element wiring 171 except for the position of the electrode 16. Then, a second adhesive layer 42 is disposed on one surface of the second reference layer 132.

According to the electrode sheet 1 of the fifth embodiment described above, in addition to the effect of (14) above, the following effects can be achieved.

(15) The optical element wiring 171 and the electrode 16 are formed on the cover layer 26C of the optical signal acquisition section 15. Thereby, the optical element wiring 171 and the electrode 16 can be easily formed.

Although the preferred embodiments of the electrode sheet of the present invention have been described above, the present invention is not limited to the above-mentioned embodiments, and may be appropriately modified.

For example, in the above embodiment, the indicator portion 12 is a straight line formed along the bridge of the nose, but it is not limited to this. For example, a straight line Y that divides one surface of the flexible substrate 10 may be used as the indicator portion 12. In addition, although the electrode 16 and the optical element 18 may be used as the marking portion 12 by making the flexible substrate 10 a highly transparent material, the flexible substrate 10 is preferable because it has elasticity and flexibility. In order to provide another indicator portion 12.

In addition, in the above embodiment, the plurality of electrodes 16, 16, ..., and the plurality of optical elements 18, 18, ... are aligned and aligned in a predetermined direction. In addition, each of the plurality of electrodes 16, 16, ... and each of the plurality of electrodes 16, 16, ... may be juxtaposed at a position overlapping in a direction perpendicular to the predetermined direction juxtaposed. In other words, each of the plurality of electrodes 16, 16,... And each of the plurality of optical elements 18, 18 may be arranged in a pair. As a result, the possibility of obtaining electrical biomedical signals and photo-student medical signals can be obtained at close positions, which can improve the accuracy of analyzing biomedical signals. In addition, in the present embodiment, although it is conceivable to provide seven optical elements 18 corresponding to the seven electrodes 16, it is not limited to this. For example, consider providing one optical element 18 for two electrodes 16 or one optical element 18 for three electrodes 16 or, conversely, two or three corresponding ones for one electrode 16 Optical element 18. Therefore, the ratio of the number of the electrodes 16 to the number of the optical elements 18 can be appropriately selected.

In addition, only one electrical signal acquisition unit 14 may be disposed on the flexible substrate 10, and the optical signal acquisition unit 15 may be disposed in plural on the flexible substrate 10. In this case, since the pair of the light emitting section 20 and the light receiving section 21 are located at a plurality of positions on the flexible substrate 10, at least the analysis accuracy of the biomedical signal obtained optically can be improved. In addition, it is preferable that three or more optical signal acquisition units 15 be disposed on the flexible substrate, more than five, and particularly preferably eight or more.

In addition, the electrical signal acquisition unit 14 is disposed in a region obtained by dividing one surface of the flexible substrate 10 by a straight line Y. In addition, the optical signal acquisition section 15 is disposed in another area. However, it is not limited to this. The optical signal acquisition section 15 may be disposed in any one of an area and another area.

In the above embodiment, the soft layer 23 is described as having one Young's coefficient, but it is not limited to this. For example, the soft layer 23 may be formed by stacking a plurality of layers having different Young's coefficients. Such a soft layer 23 is preferably formed such that the closer the inner wall of the through hole 105 is to the hard layer 22, the higher the Young's coefficient (gradient hardness structure).

In addition, the electrode sheet 1 according to the above embodiment may be provided with a plurality of optical elements 18, 18,.... Then, by scanning the plurality of optical elements 18, 18,... To output the most powerful biomedical signal, the analysis device 2 can select the most suitable optical element 18 for obtaining biomedical signals.

In addition, the optical signal acquisition section 15 of the electrode sheet 1 according to the above-mentioned embodiment includes one light receiving section 21 with respect to one light emitting section 20. However, the present invention is not limited to the above embodiments. Specifically, as shown in FIG. 18, the optical signal acquisition unit 15 may include a plurality of light receiving units 21 with respect to one light emitting unit 20. For example, the optical signal acquisition unit 15 may include four light receiving units 21 with respect to one light emitting unit 20. This makes it possible to more easily obtain a biomedical signal by expanding the light-receiving area.

In addition, the biomedical signal obtained through the electrode sheet 1 according to the above-mentioned embodiment is analyzed by the analysis device 2 in the flow shown in FIG. 19.

First, the biomedical signal obtained by the electrode sheet 1 is transmitted to the analysis device 2. The biomedical signal is input into the analysis device 2 and the biomedical signal is displayed (step S1). Next, the analysis device 2 performs a parameter check (step S2). As a parameter check, the analysis device 2 performs a parameter check such as an input time range, an amplitude option selection, and a filter bandwidth selection.

Next, the analysis device 2 removes noise from the biomedical signal (step S3). The analysis device 2 uses, for example, a software-based 0.3 to 5 Hz band-pass filter to remove noise by filtering a photoelectric pulse wave (PPG) signal. Next, the analysis device 2 detects a high peak and a low peak of the amplitude (step S4). The analyzer 2 displays the detected low peaks and high peaks.

Next, the analysis device 2 displays the average amplitude and the heart rate (step S5). Next, the analysis device 2 records the displayed biomedical signal information (step S6).

Claims (12)

    An electrode sheet includes: a piece of flexible substrate; and a biomedical signal acquisition unit configured on the flexible substrate to obtain biomedical signals of a living body, wherein the biomedical signal acquisition unit includes: An electrical signal acquisition section arranged on the flexible substrate and capable of obtaining a biomedical signal electrically; and a plurality of optical signal acquisition sections arranged on the flexible substrate and obtained by irradiating light to a living body A biomedical signal based on the light irradiated.         The electrode sheet according to item 1 of the scope of patent application, wherein the electrical signal acquisition section is disposed in an area obtained by bisecting one surface of the flexible substrate in a straight line, and the optical signal acquisition section is disposed in another area. .         The electrode sheet according to item 2 of the scope of patent application, wherein the electrical signal acquisition section includes a plurality of electrodes juxtaposed in a predetermined direction along a surface of the flexible substrate, and the optical signal acquisition section includes a plurality of electrodes. The plurality of optical elements are arranged side by side in substantially the same direction.         The electrode sheet according to item 3 of the scope of patent application, wherein the plurality of electrodes are arranged side by side in parallel with a straight line that divides one surface of the flexible substrate to form two regions.         The electrode sheet according to item 3 or 4 of the scope of the patent application, wherein the optical signal obtaining portion is formed of a material having a higher Young's coefficient than the flexible substrate, and further includes an optical element that surrounds the optical element while contacting the optical element A protective layer.         The electrode sheet according to item 5 of the scope of patent application, wherein the protective layer comprises: a hard layer contacting the optical element; and a soft layer formed of a material having a Young's coefficient lower than the hard layer, and Adjacent contacts are made to the hard layer.         According to the electrode sheet described in any one of the claims 1 to 6, in order to contact the electrical signal acquisition section and the optical signal acquisition section to the measurement position of the living body, it also includes a plan that can be aligned to the living body. A marker for the location.         The electrode sheet according to any one of claims 1 to 7, wherein the flexible substrate is formed of a reference layer, and the reference layer includes: a first reference layer configured with the electrical signal acquisition section; And a second reference layer, which is configured with the optical signal acquisition section; wherein the first reference layer and the second reference layer are configured to partially overlap.         The electrode sheet according to any one of item 8 of the scope of patent application, wherein the plurality of electrodes and a part of the wiring for the optical element connected to the optical signal acquisition section are arranged on one side of the first reference layer. ; In the second reference layer, an insertion hole formed in a thickness direction and other portions of the optical element wiring formed on one surface are arranged; the first reference layer and the second reference layer are inserted into the plurality of electrodes to The insertion holes overlap each other.         The electrode sheet according to item 9 of the scope of patent application, wherein the optical signal acquisition section is overlapped on one side of the second reference layer.         The electrode sheet according to item 9 or 10 of the scope of patent application, wherein the optical element wiring is sandwiched in a thickness direction between the first reference layer and the second reference layer.         An electrode sheet module includes: the electrode sheet according to any one of claims 1 to 11 of the scope of patent application; and a wireless device connected to the flexible substrate and sending the biomedical signal wirelessly Biomedical signals obtained by the acquisition department.