TW201827007A - Method and device for measuring biological status parameters - Google Patents

Abstract

A method and device for measuring biological status parameters are provided. The method includes the following steps: during a predetermined constant period, applying a predetermined specific voltage to a biological specimen to be examined and obtaining a first current; during a predetermined vary period, applying a predetermined varying voltage to the biological specimen and obtaining a second current; calculating a blood biochemical index according to the first and second currents. The predetermined varying voltage has a predetermined varying frequency and predetermined varying amplitude.

Description

Biological parameter measuring method and device thereof

The invention relates to a biological parameter measuring method and a device thereof, in particular to a biological parameter measuring method and a device thereof for improving numerical accuracy by voltage value, frequency and amplitude.

With the advancement of science and technology and changes in human living habits, the field of home care has received more and more attention. In addition to being able to grasp the immediate situation of patients at any time, many test items that were originally required to go to the hospital can be developed to measure at home, among which blood sugar Measurement is a common test, and measuring the concentration of blood sugar in the blood is an important step in the effective monitoring and treatment of diabetes. However, at present, home or portable blood glucose testing machines often have large error values, which are disadvantages and problems that users are criticized. For blame, the most influential factor is the hematocrit (HCT) ratio in blood samples.

The detection principle of the general test piece is mainly to use the test object in the blood sample to react with the reagent on the test piece, and at a fixed frequency, the current value of the test piece is measured by the DC voltage, and then the conversion is performed. Formula to find the concentration of the analyte. However, such a detection method is easily interfered by blood cells in the blood, thereby affecting the correctness of the measurement, such as uneven viscosity of the blood, resulting in different efficiency of electron transfer, and affecting the measured current value. .

As described above, the inventors of the present invention have conceived and designed a biological parameter measurement method and apparatus thereof, in order to improve the lack of the prior art, thereby enhancing the implementation and utilization of the industry.

In view of the above-mentioned problems of the prior art, it is an object of the present invention to provide a biological parameter measurement method and apparatus thereof to solve the shortcomings of the prior art.

According to the purpose of the present invention, a biological parameter measurement method is proposed, which is applicable to a biological parameter measurement device. The biological parameter measurement method may include the following steps: applying a preset specific voltage to a biological sample to be tested in a preset fixed time interval. And obtaining the first measured current value; in the preset change time interval, the preset change voltage is applied to the biological sample to be tested, and the second measured current value is obtained; and the first measured current value and the second measured current are determined according to the first measured current value Estimate the value of blood biochemical indicators. The preset variation voltage may have a preset variation frequency and a preset variation amplitude.

Preferably, in the step of obtaining the second measured current value, the preset change voltage may be in a state of being incremented or decremented by the preset voltage value, and the preset change frequency of the preset change voltage and the preset change amplitude may be It is in a fixed state.

Preferably, in the step of obtaining the second measured current value, the preset change frequency of the preset change voltage may be in a fixed state, and the preset change amplitude of the preset change voltage may be incremented or decremented by a preset amplitude value. status.

Preferably, in the step of obtaining the second measured current value, the preset change amplitude of the preset change voltage may be in a fixed state, and the preset change frequency of the preset change voltage may be incremented or decremented by the preset frequency value. status.

Preferably, before the step of obtaining the first measured current value, the following steps may be further included:

A preset initial voltage is applied to the biological sample to be tested in a preset initial time interval.

Preferably, after the step of obtaining the first measured current value and before the step of obtaining the second measured current value, the following steps may be further included:

A predetermined specific voltage is applied to the biological specimen to be tested at a preset specific time interval.

In accordance with the purpose of the present invention, a biometric parameter measuring device is provided that includes a receiving cavity, a working electrode, a reference electrode, and a control unit. The accommodating cavity can accommodate the biological sample to be tested. The working electrode is located in the receiving cavity. The reference electrode is located in the accommodating cavity and adjacent to the working electrode. The control unit is electrically connected to the working electrode and the reference electrode, and the control unit can selectively supply the working electrode to preset a specific voltage or a preset change voltage, and the preset change voltage can have a preset change frequency and a preset change amplitude. The control unit applies a preset specific voltage to the biological sample to be tested through the working electrode in a preset fixed time interval to obtain a first measured current value, and the control unit transmits the working electrode in the preset change time interval. The preset change voltage is applied to the biological sample to be obtained to obtain the second measured current value; the control unit estimates the blood biochemical index value according to the first measured current value and the second measured current value.

Preferably, the preset change voltage may be in a state of being incremented or decremented by a preset voltage value, and the preset change frequency of the preset change voltage and the preset change amplitude may be in a fixed state.

Preferably, the preset voltage value can be between 0 and 1000 mV.

Preferably, the preset voltage value can be between 0 and 100 mV.

Preferably, the preset change time interval may be between 1 and 10 seconds.

Preferably, the preset fixed time interval may be between 1 and 10 seconds.

Preferably, the preset change frequency of the preset change voltage may be in a fixed state, and the preset change amplitude of the preset change voltage may be in a state of increasing or decreasing the preset amplitude value.

Preferably, the preset variation amplitude of the preset variation voltage may be in a fixed state, and the preset variation frequency of the preset variation voltage may be in a state of increasing or decreasing the preset frequency value.

Preferably, the preset specific voltage may have a preset specific frequency and a preset specific amplitude, and the preset specific frequency and the preset specific amplitude may be preset waveforms.

Preferably, the preset specific frequency can be between 10 Hz and 10 KHz, and the preset specific amplitude can be between 1 and 1000 mV.

Preferably, the preset waveform may be a triangular waveform, a square wave or a sine wave.

Preferably, the control unit applies a preset initial voltage to the biological specimen to be tested through the working electrode in a preset initial time interval.

Preferably, the preset initial voltage can be between 0 and 2000 mV.

Preferably, the preset initial time interval may be between 1 and 10 seconds.

Preferably, the control unit applies a preset specific voltage to the biological sample to be tested through the working electrode at a preset specific time interval.

According to the above, the biological parameter measurement method and the device thereof can drive the preset voltage value, the preset change frequency and the preset change amplitude of the preset change voltage to drive the biological sample to be tested. The substance is oscillated and evenly mixed to reduce the range of deviation, and increase the stability and correctness of the obtained second measured current value, thereby improving the stability and correctness of the estimated blood biochemical index value.

The technical features, contents, and advantages of the present invention, as well as the advantages thereof, can be understood by the present inventors, and the present invention will be described in detail with reference to the accompanying drawings. The subject matter is only for the purpose of illustration and supplementary description. It is not necessarily the true proportion and precise configuration after the implementation of the present invention. Therefore, the scope and configuration relationship of the attached drawings should not be limited to the scope of patent application of the present invention. Narration.

The embodiments of the biological parameter measurement method and the apparatus thereof according to the present invention will be described below with reference to the related drawings. For the sake of understanding, the same components in the following embodiments are denoted by the same reference numerals.

Please refer to FIG. 1 , which is a first flow chart of the biological parameter measurement method of the present invention, and refer to FIG. 3 to FIG. 8 . As shown in the figure, the biological parameter measurement method is applicable to the biological parameter measurement device, and the biological parameter measurement method may include the following steps:

Step S11: applying a preset specific voltage to the biological specimen to be tested in a preset fixed time interval, and obtaining a first measured current value;

Step S13: applying a preset variation voltage to the biological sample to be tested in the preset change time interval, and obtaining a second measurement current value;

Step S14: estimating the blood biochemical index value according to the first measured current value and the second measured current value.

The preset variation voltage may have a preset variation frequency and a preset variation amplitude.

In an embodiment, in the step S13 of obtaining the second measured current value, the preset changing voltage is preferably in a state of being incremented or decremented by a preset voltage value, and the preset changing frequency of the preset changing voltage is preset. The amplitude of the change with the preset can be fixed.

In an embodiment, in the step S13 of obtaining the second measured current value, the preset change frequency of the preset change voltage may be in a fixed state, and the preset change amplitude of the preset change voltage may preferably be increased or Decrease the state of the preset amplitude value.

In an embodiment, in the step S13 of obtaining the second measured current value, the preset change amplitude of the preset change voltage may be in a fixed state, and the preset change frequency of the preset change voltage may preferably be incremented or Decrease the state of the preset frequency value.

Please refer to FIG. 2 , which is a second flow chart of the biological parameter measurement method of the present invention, and please refer to FIG. 3 to FIG. 8 together. As shown in the figure, before the step S11 of obtaining the first measured current value, the biological parameter measuring method of the present invention preferably further comprises the following steps:

Step S10: Applying a preset initial voltage to the biological specimen to be tested in a preset initial time interval.

Further, before the step S11 of obtaining the first measured current value and the step S13 of obtaining the second measured current value, the method further preferably includes the following steps:

Step S12: Applying a preset specific voltage to the biological specimen to be tested in a preset specific time interval.

Although the foregoing merely describes the biological parameter measurement method of the present invention, for the sake of clarity, please refer to the following detailed description of the embodiment of the biological parameter measuring device of the present invention.

Please refer to FIG. 3 to FIG. 5 , which are schematic structural diagrams, block diagrams and voltage application diagrams of the first embodiment of the biological parameter measuring device of the present invention, and please refer to FIG. 1 and FIG. 2 together. As shown, the biological parameter measuring device 1 of the present invention comprises a receiving cavity 10, a working electrode 11, a reference electrode 12 and a control unit 13. The accommodating cavity 10 can accommodate the biological sample 2 to be tested. The working electrode 11 is located in the accommodating cavity 10. The reference electrode 12 is located in the accommodating cavity 10 and adjacent to the working electrode 11. The control unit 13 is electrically connected to the working electrode 11 and the reference electrode 12, and the control unit 13 can selectively supply the working electrode 11 with a preset specific voltage 130 or a preset variation voltage 131. The preset variation voltage 131 can have a preset variation frequency 131A and The preset change amplitude is 131B. The control unit 13 applies a preset specific voltage 130 to the biological sample 2 to be measured through the working electrode 11 in a predetermined fixed time interval to obtain the first measured current value 132, and the control unit 13 is at the preset change time. In the interval, the preset change voltage 131 is applied to the biological sample 2 to be measured through the working electrode 11 to obtain the second measured current value 133; the control unit 13 according to the first measured current value 132 and the second measured current value 133 Estimate blood biochemical indicator value 134.

Specifically, the biological parameter measuring device 1 of the present invention comprises an accommodating cavity 10, a working electrode 11, a reference electrode 12 and a control unit 13, and the accommodating cavity 10 can be a test piece structure of a conventional measuring biological parameter. And having a receiving groove 100 for accommodating the biological sample 2 to be tested, such as blood. The working electrode 11 and the reference electrode 12 can be disposed in the receiving slot 100 and electrically connected to the control unit 13 .

Therefore, in the process of obtaining the blood biochemical index value 134, the biological parameter measuring device 1 of the present invention may first supply the preset specific voltage 130 to the working electrode 11 via the control unit 13, wherein the preset specific voltage 130 may have a voltage change. The fixed waveform may preferably have a preset specific frequency 130A and a preset specific amplitude 130B. The preset specific frequency 130A may be between 10 Hz and 10 KHz, and the preset specific amplitude 130B may be between 1 and 1000 mV. Moreover, the preset specific frequency 130A and the preset specific amplitude 130B may be preset waveforms, such as a triangular waveform, a square wave, or a sine wave, but are not limited thereto. Then, the preset specific voltage 130 is transmitted through the working electrode 11 to the biological sample 2 to be tested, and maintained for a preset fixed time interval (which may be between 1 and 10 seconds, that is, greater than 0 seconds, less than or equal to 10 seconds), and then The first measurement current value 132 is obtained by turning on the working electrode 11 and the reference electrode 12 via the biological sample 2 to be tested.

Furthermore, the control unit 13 can supply the preset variation voltage 131 to the working electrode 11 and maintain a preset change time interval (which can be between 1 and 10 seconds, that is, greater than 0 seconds, less than or equal to 10 seconds). The electrode 11 can conduct the preset change voltage 131 to the biological sample 2 to be tested, and obtain the second measured current value 133. The preset voltage value 131C may be between 0 and 1000 mV, preferably between 0 and 100 mV.

Finally, the control unit 13 may estimate the blood biochemical index value 134, such as the blood volume ratio (Hct%), based on the first measured current value 132 and the second measured current value 133.

It is noted that, in the process of obtaining the second measured current value 133, the control unit 13 can control the preset change frequency 131A of the preset change voltage 131 and the preset change amplitude 131B to maintain a fixed state, and increase or decrease by one. The preset voltage value 131 is applied to the biometric body 2 to be tested to obtain the second measured current value 133. Then, the blood biochemical index value 134 is estimated based on the first measured current value 132 and the second measured current value 133.

Therefore, the biological parameter measuring device 1 of the present invention can drive the biological sample 2 to be tested to oscillate by the preset variation voltage 131, and uniformly mix the substances, thereby increasing the stability of the acquired second measuring current value 133. And correctness, and reduce the error range, thereby improving the stability and correctness of the estimated blood biochemical index 134.

Further, the control unit 13 applies a preset initial voltage 135 to the biological sample 2 to be measured through the working electrode 11 in a preset initial time interval. Moreover, the preset initial voltage 135 can be between 0 and 2000 mV, and the preset initial time interval can be between 1 and 10 seconds.

In other words, the biometric parameter measuring device 1 of the present invention can provide a predetermined initial voltage 135 to the working electrode 11 by the control unit 13 before performing the step of obtaining the first measured current value 132. The biological specimen 2 applies a preset initial voltage 135, and the process is maintained for a predetermined initial time interval.

Please refer to FIG. 6 , which is a schematic diagram of voltage application of the second embodiment of the biological parameter measuring device of the present invention, and please refer to FIG. 1 to FIG. 5 together. As shown in the figure, the biological parameter measuring device in this embodiment is similar to the operation of the same components described in the biological parameter measuring device of the first embodiment, and therefore will not be described herein. However, it is worth mentioning that, in this embodiment, the preset variation amplitude 131B of the preset variation voltage 131 may be in a fixed state, and the preset variation frequency 131A of the preset variation voltage 131 may preferably be incremented or decremented. Set the state of the frequency value.

For example, in an embodiment, the biological parameter measuring device 1 of the present invention can apply a preset change to the biological sample 2 to be measured via the working electrode 11 after the control unit 13 obtains the first measured current value 132. Voltage 131 is obtained to obtain a second measured current value 133. In the process of obtaining the second measured current value 133, the control unit 13 can control the preset voltage value 131C of the preset change voltage 131 and the preset change amplitude 131B to maintain a fixed state. At the same time, the preset change voltage 131 is applied to the biological sample 2 to be tested by increasing or decreasing the preset frequency value of one of the preset change frequencies 131A (which may be between 10 Hz and 10 KHz) to obtain the second amount. The current value is 133. Then, the blood biochemical index value 134 is estimated based on the first measured current value 132 and the second measured current value 133.

Please refer to FIG. 7 , which is a schematic diagram of voltage application of the third embodiment of the biological parameter measuring device of the present invention, and please refer to FIG. 1 to FIG. 6 together. As shown in the figure, the biological parameter measuring device in this embodiment is similar to the operation of the same components described in the biological parameter measuring device of the above embodiments, and therefore will not be described herein. However, it is worth mentioning that, in this embodiment, the preset change frequency 131A of the preset change voltage 131 may be in a fixed state, and the preset change amplitude 131B of the preset change voltage 131 may preferably be incremented or decremented. Set the state of the amplitude value.

Specifically, in an embodiment, the biological parameter measuring device 1 of the present invention can apply a preset change to the biological sample 2 to be measured via the working electrode 11 after the control unit 13 obtains the first measured current value 132. Voltage 131 is obtained to obtain a second measured current value 133. In the process of obtaining the second measured current value 133, the control unit 13 can control the preset voltage value 131C of the preset change voltage 131 and the preset change frequency 131A to maintain a fixed state. At the same time, the preset variation voltage 131 is applied to the biological sample 2 to be tested to obtain the second amount by incrementing or decrementing one of the preset amplitudes 131B (which may be between 1 and 1000 mV). The current value is 133. Then, the blood biochemical index value 134 is estimated based on the first measured current value 132 and the second measured current value 133.

Please refer to FIG. 8 , which is a schematic diagram of voltage application of the fourth embodiment of the biological parameter measuring device of the present invention, and please refer to FIG. 1 to FIG. 7 together. As shown in the figure, the biological parameter measuring device in this embodiment is similar to the operation of the same components described in the biological parameter measuring device of the above embodiments, and therefore will not be described herein. However, it is worth mentioning that, in the present embodiment, preferably, the control unit 13 applies a preset specific voltage 136 to the biological sample 2 to be measured through the working electrode 11 in a preset specific time interval.

For example, in an embodiment, the biometric parameter measuring device 1 of the present invention can also supply a preset specific voltage 136 by the control unit 13 after obtaining the first measured current value 132 (may be between 1~) 100 mV) to the working electrode 11, applying a preset specific voltage 136 to the biological sample 2 to be tested, and maintaining a predetermined specific time interval, such as 1 to 500 milliseconds. Then, the step of obtaining the second measured current value 133 is performed.

The above is intended to be illustrative only and not limiting. Any equivalent modifications or alterations to the spirit and scope of the invention are intended to be included in the scope of the appended claims.

1‧‧‧ Biological parameter measuring device

10‧‧‧ accommodating cavity

100‧‧‧ accommodating slots

11‧‧‧Working electrode

12‧‧‧ reference electrode

13‧‧‧Control unit

130‧‧‧Preset specific voltage

130A‧‧‧Preset specific frequency

130B‧‧‧Preset specific amplitude

131‧‧‧Preset change voltage

131A‧‧‧Preset change frequency

131B‧‧‧Preset change amplitude

131C‧‧‧Preset voltage value

132‧‧‧First measurement current value

133‧‧‧Second measurement current value

134‧‧‧ Blood biochemical indicators

135‧‧‧Preset initial voltage

136‧‧‧Preset specific voltage

2‧‧‧ Biological samples to be tested

S11~S14‧‧‧Steps

Figure 1 is a first flow chart of the biological parameter measurement method of the present invention. Figure 2 is a second flow chart of the biological parameter measurement method of the present invention. Figure 3 is a schematic view showing the structure of the first embodiment of the biological parameter measuring device of the present invention. Figure 4 is a block diagram of a first embodiment of the biological parameter measuring device of the present invention. Fig. 5 is a view showing the voltage application of the first embodiment of the biological parameter measuring device of the present invention. Figure 6 is a schematic diagram showing the voltage application of the second embodiment of the biological parameter measuring device of the present invention. Figure 7 is a schematic diagram showing the voltage application of the third embodiment of the biological parameter measuring device of the present invention. Figure 8 is a diagram showing the voltage application of the fourth embodiment of the biological parameter measuring device of the present invention.

Claims (14)

A biological parameter measuring method is applicable to a biological parameter measuring device, and the biological parameter measuring method comprises the following steps: applying a preset specific voltage to a biological sample to be tested in a predetermined fixed time interval, And obtaining a first measured current value; applying a preset change voltage to the biological sample to be tested in a predetermined change time interval, and obtaining a second measured current value; and determining the current value according to the first measured value And estimating a blood biochemical index value from the second measured current value; wherein the preset variation voltage has a preset variation frequency and a preset variation amplitude. The biological parameter measurement method of claim 1, wherein in the step of obtaining the second measurement current value, the preset variation voltage is in a state of being incremented or decremented by a preset voltage value. And the preset variation frequency of the preset variation voltage and the preset variation amplitude are in a fixed state. The biological parameter measurement method of claim 1, wherein in the step of obtaining the second measured current value, the preset change frequency of the preset change voltage is in a fixed state, and the preset The preset variation amplitude of the varying voltage is in a state of increasing or decreasing a predetermined amplitude value. The biological parameter measurement method of claim 1, wherein in the step of obtaining the second measurement current value, the preset variation amplitude of the preset variation voltage is in a fixed state, and the preset The preset change frequency of the varying voltage is in a state of increasing or decreasing a predetermined frequency value. The biological parameter measurement method according to claim 1, wherein before the step of obtaining the first measurement current value, the method further comprises the following steps: the biological sample to be tested is in a preset initial time interval. A predetermined initial voltage is applied. The method for measuring a biological parameter according to claim 1, wherein the step of obtaining the first measured current value and the step of obtaining the second measured current value further comprises the following steps: A predetermined time interval is set, and a predetermined specific voltage is applied to the biological sample to be tested. A biological parameter measuring device comprises: a receiving cavity for accommodating a biological sample to be tested; a working electrode located in the accommodating cavity; and a reference electrode located in the accommodating cavity And adjacent to the working electrode; and a control unit electrically connected to the working electrode and the reference electrode, the control unit selectively supplying the working electrode with a predetermined specific voltage or a preset variation voltage, the pre-predetermined voltage The variable voltage system has a preset change frequency and a preset change amplitude; wherein the control unit applies the preset specific voltage to the biological sample to be tested through the working electrode in a predetermined fixed time interval, Obtaining a first measured current value, and the control unit applies the preset change voltage to the biological sample to be tested through the working electrode in a preset change time interval to obtain a second measured current value. The control unit estimates a blood biochemical index value according to the first measured current value and the second measured current value. The biometric parameter measuring device of claim 7, wherein the preset varying voltage is in a state of being incremented or decremented by a predetermined voltage value, and the preset changing frequency of the preset varying voltage is The preset variation amplitude is in a fixed state. The biological parameter measuring device according to claim 8, wherein the preset voltage value is between 0 and 1000 mV. The biological parameter measuring device of claim 7, wherein the preset change frequency of the preset change voltage is in a fixed state, and the preset change amplitude of the preset change voltage is increasing or decreasing. The state of a preset amplitude value. The biological parameter measuring device of claim 7, wherein the preset variation amplitude of the preset variation voltage is in a fixed state, and the preset variation frequency of the preset variation voltage is increasing or decreasing. The state of a preset frequency value. The biometric parameter measuring device of claim 7, wherein the preset specific voltage has a predetermined specific frequency and a predetermined specific amplitude, and the preset specific frequency is one with the preset specific amplitude. Preset waveform. The biological parameter measuring device according to claim 12, wherein the preset specific frequency is between 10 Hz and 10 KHz, and the preset specific amplitude is between 1 and 1000 mV. The biological parameter measuring device according to claim 7, wherein the control unit applies a predetermined specific voltage to the biological sample to be tested through the working electrode in a predetermined specific time interval.