TW201820314A - Method of mixing frequency following response evoked sounds with music to modulate neuronal networks associated with multiple intelligences in the brain serving as objective quantitative biological indicators and derivative products for neuronal responses in the brain - Google Patents

Abstract

The invention relates to a method of mixing frequency following response (FFR) evoked sounds with music to modulate neuronal networks associated with multiple intelligences in the brain that includes processes of sound wave mixture and magnetic resonance imaging combination. The method includes steps of performing synthesis and establishment of FFR sound waves, importing FFR sound waves into a music library, performing collection and analysis of magnetic resonance imaging data of cerebral nerve activity activated by introducing FFR sound waves into music, and establishing biological indicators for monitoring. In this way, the present invention can develop a method for introducing FFR sound waves into music, which can modulate neural circuits in the brain corresponding to eight major intelligences, by means of the establishment of FFR sound wave frequency, accompanied by the mixing method and music synthesis, and can be used as objective quantitative biological indicators and derivative products for neuronal responses in the brain corresponding to eight major intelligences in response to the stimulation and regulation of music introduction. The eight major intelligences include language intelligence, logic math intelligence, spatial intelligence, limb kinetic intelligence, music intelligence, interpersonal intelligence, introspective intelligence, and natural observation intelligence.

Description

   Method for adjusting eight FMR sound waves corresponding to different neural circuits in the brain (frequency imitating response sound waves) into music method   

The present invention relates to a technical field of frequency imitating response acoustic wave introduction music combined with magnetic resonance imaging data to establish an objective quantitative biological index that can help regulate the neural response corresponding to eight multiple intelligences in the brain, and in particular, it refers to a method of using frequency imitating response acoustic wave Synthesis and establishment, the introduction of frequency imitating response acoustic waves into the music database, the frequency imitating response acoustic waves leading to music, the collection and analysis of magnetic resonance imaging data of brain neural activity, and a step of establishing monitoring biological indicators.

According to the past, the evidence and technology only provided the brain wave frequency energy regulation corresponding to the brain wave outside the head shell and the frequency imitating response. For the first time, the invention adopts the method of sonic mixing and magnetic resonance imaging to provide different neural circuits in the brain corresponding to the eight multiple intelligent intelligences. The adjustment.

Frequency Following Response (FFR) refers to a physiological phenomenon in which the frequency of brain neuron activity is synchronized with the frequency of external stimuli. Therefore, we can guide the frequency of neuronal activity in the brain through auditory tones, visual flashes, and tactile taps. Many studies have confirmed that the frequency imitative response can bring beneficial physiological and psychological effects. Therefore, the frequency imitative response has very good research prospects and the potential to become an alternative and complementary treatment. The theory of multiple intelligences was proposed by Gardner, a psychological development scientist at the Harvard Institute of Education in 1983. Gardner came up with this theory by studying patients with traumatic brains who noticed differences in their learning abilities. Although multiple intelligences are classified so finely according to endowments, they should not be used to limit people to a certain type of intelligence. Each person has a unique set of intelligence combinations. According to the existing evidence, human intelligence can be divided into at least eight categories, including language intelligence, logic and mathematics intelligence, space intelligence, limb kinematic intelligence, music intelligence, interpersonal intelligence, introspective intelligence, and natural observation intelligence.

Through research in patients with brain damage, diseases or injuries in certain areas of the brain selectively impair specific intelligence while maintaining its integrity. For example, damage to the Broca region in the left frontal lobe of a brain can disrupt a person's ability to speak or read, but the individual is usually still able to draw, hum, skate, or smile because these functions are related to the undamaged areas of the brain Related. However, individuals with damage to the right temporal lobe may lose the ability to adjust tones, but retain the ability to speak, read, and write. Broadly speaking, the available evidence points out that the corresponding major brain regions in the eight major multiple intelligences are as follows: Chinese intelligence: left temporal and frontal lobe; logical mathematical intelligence: left prefrontal and right parietal lobe; spatial intelligence: occipital and parietal lobe Region (especially the right hemisphere); limb kinematic intelligence: cerebellum, basal ganglia, motor cortex; musical intelligence: right temporal lobe; interpersonal intelligence: anterior lobe, temporal lobe (especially right hemisphere), limbic system; introspective intelligence: Frontal, parietal, limbic systems; natural observation intelligence: left parietal lobe (important for distinguishing between "living" and "nonliving").

However, in the past, only the effect of brain wave frequency energy corresponding to the brain wave outside the head shell and the frequency emulation response was provided. For the first time, the present invention directly adopts the method of sonic mixing and magnetic resonance imaging to directly provide evidence for the regulation of the eight multiple intelligent neural circuits in the brain. Mixing can adjust the frequency imitating response audio and music corresponding to different cognitive function brain regions, and successfully developed a method that can adjust the frequency imitating response sound wave of eight multi-intelligent intelligent related neural circuits into music to match the frequency imitating response. The potential of regulation and treatment alternatives or complementary treatments provides objective and quantitative indicators of effectiveness.

Passing a stable oscillating audio into the ear can trigger a frequency imitative response that synchronizes the frequency of brain neuron activity with the frequency of external stimuli. The frequency of brain neuronal activity and discharge will correspond to the frequency of the external incoming sound. Therefore, the main purpose of the present invention is to use the frequency field to imitate the response of the brain frequency imitating response caused by the stable oscillating sound wave, mix the frequency imitating the response of sound wave and music, and combine the magnetic resonance imaging data to use the frequency imitating response to the sound wave. Music, establish a method that can adjust the frequency of eight multi-intelligence-related neural circuits to imitate the response of sound waves to music. According to this, the present invention mainly implements the foregoing purposes and effects through the following technical means. It includes: a step of synthesizing and establishing a sound wave by using a frequency imitating reaction. First of all, a frequency imitating recording of different frequencies is performed. Response sound waves, with a stable sound wave of 100 Hz and a sine wave with an oscillation of 5 to 44 Hz, with a unit of 1 Hz, a total of 40 frequency imitating response sound waves are synthesized; once the frequency imitating response sound waves enter the music database, different frequencies The frequency imitates the response sound waves into the music track by mixing. The original music is mixed with frequencies to imitate the response sound waves and is divided into eight albums, which are respectively 5-9 Hz, 10-14 Hz, and 15-19 Hz. , 20 ~ 24 Hz, 25 ~ 29 Hz, 30 ~ 34 Hz, 35 ~ 39 Hz, 40 ~ 44 Hz; a frequency imitating the steps of collecting and analyzing magnetic resonance imaging data of brain nerve activity caused by the introduction of sound waves into music The unsynthesized original music and the synthesized music imported into the sound wave were played to the subjects, and the neural activity and analysis in the brain were collected using MRI equipment. General music and frequency imitating response sound wave synthesizing music to verify the frequency imitating response sound wave music's regulating effect on different neural circuits corresponding to the eight major intelligences in the brain; and a step of establishing monitoring biological indicators, which analyzes and compares general music and frequency imitating response Sonic music to verify the frequency imitative response. The effect of sonic music on the neuronal activity in the subject ’s brain and the effect of varying degrees of behavior. Further confirm the impact of the frequency imitative response on the different neural circuits of the eight multiple intelligences in the brain. Establish objective and quantitative biological indicators that emulate the effects of sonic music on brain regulation and music promotion effect.

Through this, through the specific realization of the aforementioned technical means of creation, the frequency imitating response acoustic wave of the present invention is introduced into the music method. Through the establishment of the frequency imitating response acoustic wave music database, and the collection and analysis of magnetic resonance imaging data, different frequencies are developed. The frequency imitates the objective index that reflects the influence of sonic music on different neural circuits corresponding to the eight multi-intelligences, and provides a quantitative biological effect of music promotion effect.

In order to make your reviewers better understand the composition, features, and other purposes of the present invention, the following is a description of the preferred embodiments of the present invention, which will be described in detail with reference to the drawings, and will be implemented by those familiar with the technical field.

(S01) ‧Synthesis and establishment of ‧‧ imitating response acoustic waves

(S02) ‧‧‧ Import frequency to imitate response sound waves into music database

(S03) ‧‧‧Collection and analysis of magnetic resonance imaging data of brain nerve activity

(S04) ‧‧‧ Establish monitoring biological indicators

The first figure is a schematic flow chart of the method for adjusting the frequency of the eight multi-intelligent intelligence corresponding to different neural circuits in the brain to respond to sound waves and introducing music.

The second figure is a schematic diagram illustrating the detailed flow of the method of adjusting the frequency of eight multi-intelligent intelligences corresponding to different neural circuits in the brain and introducing sound waves into music.

    [Description of main component symbols]    

(S01) Synthesis and establishment of frequency imitating response acoustic waves

(S02) Import frequency to imitate response sound waves into music database

(S03) Collection and analysis of magnetic resonance imaging data of brain nerve activity

(S04) Establish monitoring biological indicators

The third picture: The present invention can adjust the frequency of eight multi-intelligence corresponding to different neural circuits in the brain to imitate the response of sound waves to music. The method is applied to the neurological regulation of female subjects.

The fourth picture: This invention can adjust the frequency of the eight multi-intelligence corresponding to different neural circuits in the brain. The method of imitating the response of sound waves to music is applied to the neurological regulation of male subjects.

The present invention is a method for adjusting the frequency of eight multi-intelligent intelligences in the brain corresponding to different neural circuits to imitate the response of sound waves to music. The specific embodiments of the present invention illustrated in the accompanying drawings and their components are all related to front and back, left and right, The references to top and bottom, upper and lower, and horizontal and vertical are for convenience of description only, and do not limit the invention, nor limit its components to any position or spatial direction. The dimensions specified in the drawings and the description can be changed according to the design and requirements of the specific embodiments of the present invention without departing from the scope of the patent application of the present invention.

The main architecture of the method of the present invention is shown in the first and second figures, which includes the synthesis and establishment of a frequency imitating response sound wave (S01), introducing the frequency imitating response sound wave into a music database (S02), and magnetic resonance imaging data of brain nerve activity. Collection and analysis (S03), and a step of establishing a monitoring biological index (S04); wherein the frequency imitates the response sound wave synthesis and establishment (S01) step, first, recording a plurality of different frequencies of the frequency imitative response sound wave, Prepare a stable acoustic wave with a frequency of 100 Hz and a sine wave with an oscillation of 5 to 44 Hz to synthesize a total of 40 frequencies to imitate the response acoustic wave in units of 1 Hz. The steps for establishing a binaural wave difference music database (S02) are as follows. Introduce the response sound waves at the established frequency into the music track by mixing method. Mix the frequencies in the original music to imitate the response sound waves, and divide them into eight albums, in order of 5-9 Hz, 10-14 Hz, 15 ~ 19 Hertz, 20 ~ 24 Hertz, 25 ~ 29 Hertz, 30 ~ 34 Hertz, 35 ~ 39 Hertz, 40 ~ 44 Hertz; The steps of collecting and analyzing magnetic resonance imaging data for conducting nerve activity (S03), which system The unsynthesized frequency imitating response sound wave music and the frequency imitating response sound wave music are played to the subjects, and the MRI equipment is used to collect neural activity and analysis in the brain. The general music and synthetic music are compared to verify the frequency imitative response sound wave music pair. Regulating effects of neural activity in the brain, we asked a 55-year-old healthy, volunteer male subject and a 32-year-old healthy, volunteer female subject to listen to eight albums of synthesized music in order, respectively. 5 to 9 Hz, 10 to 14 Hz, 15 to 19 Hz, 20 to 24 Hz, 25 to 29 Hz, 30 to 34 Hz, 35 to 39 Hz, 40 to 44 Hz, while recording the blood oxygen concentration in their brains The consumption rate is used as an indicator of the strength of the brain's neural activity, and we additionally let the two subjects listen to unsynthesized general music as a standard for comparison; the steps for establishing a monitoring biological index (S04), first, The system analyzes and compares the frequency of imitating the response of sonic music and general music, and finds out that the frequency of imitating the response of sonic music can trigger a unique Neural activity is related to the indicators of the brain area corresponding to the eight major intelligences in the brain, and the frequency of imitative response to sonic music affects the subject to varying degrees of behavioral effects. Next, the brain region and cognitive neuroscience literature that frequency imitates response to sonic music are analyzed. Brain function data related to the eight major multiple intelligences. Finally, an objective and quantitative biological indicator of the frequency-like response to acoustic wave intervention to regulate the eight multi intelligence-related brain regions and music promotion effects in the brain was established.

With this, the group constitutes a person who can establish objectively quantified biological indicators and adjust the frequency of the eight multiple intelligence-related neural circuits in the brain to imitate the response of sound waves to music methods.

For the implementation of the preferred embodiment of the present invention, please refer to the first and second figures. After that, the collection and analysis of magnetic resonance imaging data of brain nerve activity are based on 3T magnetic resonance imaging of the core facilities of National Yangming University. MRI) experiments to obtain image data, and analyze the data (Statistical Parametric Mappin) with a free image processing system developed by the University of London (Wellcome Trust Centre for Neuroimaging). After obtaining the experimental data, the Montreal Neurological Institute and Hospital (Montreal The Neurological Institute and Hospital's MNI coordinates platform presents data results.

The reference URL is as follows:

3T magnetic resonance imaging (MR1) of the core facilities of National Yangming University

http: //bclab.ym.edu.tw/mri_website/mri_index.html

Statistical Parametric Mappin, a free image processing system developed by the University of London (Wellcome Trust Centre for Neuroimaging)

http: //www.fil.ion.ucl.ac.uk/spm/

MNI coordinates platform established by the Montreal Neurological Institute and Hospital

http: //imaging.mrc-cbu.cam.ac.uk/imaging/MniTalairach

Finally, a monitoring biological indicator was established. Through analysis of magnetic resonance imaging data, it was found that the frequency imitating response sound wave into music method applied to the female subject's brain nervous system regulation is as follows: 5-9 Hz album adjustable logic mathematics intelligent correlation Brain regions; 10-14 Hz albums can adjust spatial intelligence and limb-kinesthetic intelligence-related brain regions; 20-24 Hz albums can adjust music intelligence and interpersonal intelligence-related brain regions; 25-29 Hz albums can adjust introspective intelligence-related brain regions ; 30-34 Hz album can adjust language intelligence, interpersonal intelligence-related brain areas; 35-39 Hz album can adjust natural observation intelligence, logic and mathematics intelligence related brain areas; 40-44 Hz album can adjust introspective intelligence, nature observation intelligence related Brain area. The frequency imitating response sound wave introduction music method applied to the male brain's nervous system regulation is as follows: 5-9 Hz can adjust the language intelligence, logical and mathematical intelligence-related brain areas; 10-14 Hz can adjust the spatial intelligence-related brain areas ; 15-19 Hz can adjust limb-kinesthetic intelligence-related brain areas; 20-24 Hz can adjust interpersonal intelligence, introspective intelligence-related brain areas; 25-29 Hz can adjust music intelligence, limb kinematic intelligence, logical mathematical intelligence, space Intelligence-related brain regions. From this, it can be understood that the present invention is an excellent creative creation. In addition to effectively solving the problems faced by practitioners, it has greatly improved the efficacy. No identical or similar processed product creation or disclosure has been seen in the same technical field. The use of the invention has the improvement of efficacy. Therefore, the present invention has already met the requirements of "novelty" and "progressiveness" of the invention patent, and has applied for an invention patent in accordance with the law.

The coordinates, statistical values and test values of the reference brain activity area are as follows:

Claims (1)

    The method of introducing eight multi-intelligent intelligent FFR sound waves (frequency imitating response sound waves) into the brain to introduce music methods includes: a step of synthesizing and establishing a frequency imitating response sound waves. First, it is to record different frequencies The frequency imitates the response acoustic wave, and uses the stable acoustic wave of 100 hertz and the sine wave of 5 to 44 hertz oscillation to synthesize 40 kinds of frequency imitative response acoustic wave in units of 1 hertz. Once the frequency imitative response acoustic wave enters the music database, The frequencies imitating the response sound waves of different frequencies are introduced into the music track by mixing, and the original music is mixed with frequencies to imitate the response sound waves and divided into eight albums, which are respectively 5 ~ 9 Hz, 10 ~ 14 Hz, 15 ~ 19 Hertz, 20 ~ 24 Hertz, 25 ~ 29 Hertz, 30 ~ 34 Hertz, 35 ~ 39 Hertz, 40 ~ 44 Hertz; a frequency imitating the steps of collecting and analyzing magnetic resonance imaging data of brain nerve activity caused by the introduction of sound waves into music, It is to play the unsynthesized original music and the sound-introduced music to the subject, and use the MRI equipment to collect the neural activity and analysis in the brain. Analysis, comparing general music and frequency imitating response sonic synthesis music to verify the frequency imitating response sonic music's regulating effect on the different neural circuits corresponding to the eight multiple intelligences in the brain; and a step of establishing monitoring biological indicators, which analyzes and compares general music and Frequency imitating response to sonic music to verify the effect of frequency imitating response to sonic music on the neuronal activity in the subject's brain and varying degrees of behavioral effects, further confirming the effect of frequency imitating response to sonic music on the different neural circuits corresponding to the eight multiple intelligences in the brain Finally, an objective and quantitative biological indicator that emulates the effects of sonic music on brain regulation and music promotion effects is established. In this way, the group constitutes an index that can be used to establish an objectively quantified frequency imitating response to the effects of sonic music on the eight multiple intelligences corresponding to different neural circuits, and to provide a quantitative biological effect of music promotion effect to the music method.