TW201739416A - Bed set for inhibition of Obstructive Sleep Apnea - Google Patents

Bed set for inhibition of Obstructive Sleep Apnea

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Publication number
TW201739416A
TW201739416A TW105113963A TW105113963A TW201739416A TW 201739416 A TW201739416 A TW 201739416A TW 105113963 A TW105113963 A TW 105113963A TW 105113963 A TW105113963 A TW 105113963A TW 201739416 A TW201739416 A TW 201739416A
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TW
Taiwan
Prior art keywords
respiratory
sound
airway collapse
bed set
signal
Prior art date
Application number
TW105113963A
Other languages
Chinese (zh)
Other versions
TWI593390B (en
Inventor
羅孟宗
麗娟 方
文長 范
陳韻之
施庭芳
氏草 陳
林澂
王拔群
Original Assignee
國立中央大學
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Application filed by 國立中央大學 filed Critical 國立中央大學
Priority to TW105113963A priority Critical patent/TWI593390B/en
Priority to US15/293,632 priority patent/US10500085B2/en
Application granted granted Critical
Publication of TWI593390B publication Critical patent/TWI593390B/en
Publication of TW201739416A publication Critical patent/TW201739416A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/56Devices for preventing snoring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/002Monitoring the patient using a local or closed circuit, e.g. in a room or building
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/087Measuring breath flow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4806Sleep evaluation
    • A61B5/4818Sleep apnoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6891Furniture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7246Details of waveform analysis using correlation, e.g. template matching or determination of similarity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/7405Details of notification to user or communication with user or patient ; user input means using sound

Abstract

The present invention provides a bed set for inhibition of Obstructive Sleep Apnea, which includes: a sound receiving processor; a sound analyzing processor, which is connected with the sound receiving processor, is used to obtain a snoring signal characteristic from a user's respiratory signals; a database, which is used to a plurality of store airway collapse indexes, and the store airway collapse indexes corresponded a first angle control command and a second angle control command; a control processor, which is used to compare the respiratory sound signals with the snoring signal characteristic to selecta airway collapse index in the same waveform, and provide the airway collapse indexe corresponded first angle control command and second angle control command; a first pillow and a second pillow, which is connected to the processor declining a angle toward a declination direction after receiving the first and the second control command.

Description

用於睡眠呼吸中止診療之床具組 Bed set for sleep breathing treatment

本發明係有關一種用於睡眠呼吸中止診療之床具組及其使用方法,特別是一種可透過調整床具組中枕頭的傾斜角度,避免或停止使用者產生睡眠呼吸中止症狀的床具組。 The present invention relates to a bed set for sleep breathing treatment and a method of using the same, and more particularly to a bed set capable of preventing or stopping a user from developing sleep apnea symptoms by adjusting the tilt angle of a pillow in the bed set.

睡眠呼吸暂停(Sleep Apnea,又譯作睡眠呼吸中止症或睡眠窒息症)是一種睡眠障礙,以男性、肥胖、酗酒及有服用安眠藥、鎮定劑的人機會較大,而老人患者的比例比青壯年更高。患者在睡眠中,因不能呼吸而導致睡眠呼吸中止,並常於睡夢中醒來,醒後會回復正常呼吸。類似情況在一晚可以發生數十次到數百次不等,每次醒來的時間並不一定,由數秒到超過一分鐘都有可能,患者自身不易察覺。由於睡眠斷斷續續進行,患者無法享有優質睡眠,導致白天常常打瞌睡、精神不濟、無法專心,進而影響工作及日常生活品質。 Sleep Apnea (Sleep Apnea, also translated as sleep apnea or sleep apnea) is a sleep disorder. Men, obesity, alcoholism, and people who take sleeping pills and tranquilizers have a greater chance of getting older than the young adults. higher. The patient is in sleep, unable to breathe, causing sleep and breathing to stop, and often wakes up in his sleep, and will return to normal breathing after waking up. A similar situation can occur from dozens to hundreds of times a night. The time to wake up is not necessarily the same. It can be from a few seconds to more than one minute. The patient is not aware of it. Due to the intermittent sleep, patients can not enjoy good sleep, leading to dozing off during the day, lack of energy, and can not concentrate, thus affecting the quality of work and daily life.

睡眠呼吸中止症可分為:(1)阻塞型睡眠呼吸中止症(Obstructive Sleep Apnea,OSA):最常見的一種,約有九成患者是屬於此類別。起因是咽喉附近的軟組織阻塞呼吸道,使上呼吸道變得較狹窄,進而引發鼾聲與呼吸中止。上呼吸道結構異常者(如鼻中膈彎曲、鼻甲肥大、鼻息肉增生、懸雍垂過長、扁桃腺肥大、舌根肥大等)、呼吸道肌肉過度鬆弛與肥胖等也是常見的誘因。(2)中樞型睡眠呼吸中止症(Central Sleep Apnea,CSA):由於腦部受到中風、創傷或其他問題影響,大腦不能發出呼吸指令而形成睡眠呼吸中止。另一種是中樞神經系統發生問題,呼吸訊息指令傳導異常,無法產生呼吸動作而導致呼吸停止。(3)混合型睡眠呼 吸中止症(Mixed Apnea):同時患有阻塞型與中樞型睡眠呼吸中止。 Sleep apnea can be divided into: (1) Obstructive Sleep Apnea (OSA): the most common type, about 90% of patients belong to this category. The cause is that the soft tissue near the throat blocks the airway, making the upper airway narrower, which causes the snoring and breathing to stop. Patients with abnormal upper respiratory tract structure (such as nasal sacral flexion, turbinate hypertrophy, nasal polyps hyperplasia, uvula sag, tonsil hypertrophy, tongue root hypertrophy, etc.), respiratory muscle excess relaxation and obesity are also common causes. (2) Central Sleep Apnea (CSA): Because the brain is affected by stroke, trauma or other problems, the brain can not give a breathing command to form a sleep breathing stop. The other is a problem with the central nervous system. The respiratory message is abnormally transmitted and cannot cause respiratory movements, resulting in respiratory arrest. (3) Mixed sleep call Mixed Apnea: Both blocked and central sleep breathing stops.

目前治療或預防睡眠呼吸中止疾病的方法,手術為其中一種,然而因上呼吸道構造較為複雜,並非所有患者皆適用此法。較為普遍的治療方式為側睡、減少酒精或安眠藥物的攝取。然而,側睡姿勢的維持有其先天的難度,因此患者往往依賴輔助枕頭來維持側睡姿勢。現今亦有專門抑制睡眠中止之枕頭,市售此類主張能抑制打鼾的睡眠枕頭,多藉由接收打鼾聲音訊號,將枕頭打氣以調整其高度,藉此改變使用者頭部位置,而抑制打鼾;然而,醫學所稱打鼾,尤是阻塞性睡眠呼吸暫停(Obstructive Sleep Apnea,OSA),不是單純改變頭部位置可以克服,因此,傳統的方法仍無法解決使用者睡眠時因打鼾造成呼吸中止困擾,此乃一亟待解決的問題。 Surgery is one of the current methods for treating or preventing sleep-disorders. However, due to the complex structure of the upper respiratory tract, not all patients are suitable for this method. The more common treatment is side sleeping, reducing the intake of alcohol or sleeping pills. However, the maintenance of the side-sleeping posture is inherently difficult, so patients often rely on an auxiliary pillow to maintain a side-sleeping posture. Nowadays, there are also pillows that specifically suppress sleep suspension. Commercially available such pillows can suppress sleeping pillows. By receiving a snoring sound signal, the pillow is pumped to adjust its height, thereby changing the position of the user's head and suppressing snoring. However, what the medical system calls snoring, especially obstructive sleep apnea (OSA), can not be overcome simply by changing the position of the head. Therefore, the traditional method still cannot solve the problem of breathing suspension caused by snoring when the user sleeps. This is an urgent problem to be solved.

有鑒於此,本發明提供一用於睡眠呼吸中止診療之床具組,搭配判斷睡眠呼吸中止阻塞位置的關聯資料庫,來判斷睡眠呼吸中止發生的位置,以及氣道塌陷狀況,進一步利用本發明床具組,以使用者身軀為軸心,分別以不同角度傾斜頭部以及身體,達到暢通呼吸道的功效,而後重複確認使用者的呼吸訊號,若呼吸訊號已恢復正常,則依照原傾斜方向之反方向做傾斜,讓使用者回復初始睡眠環境。 In view of the above, the present invention provides a bed set for sleep breathing and medical treatment, and a related database for determining the position of sleep breathing to stop the blockage, to determine the position of sleep breathing suspension, and the airway collapse condition, and further utilize the bed of the present invention. With the user's body as the axis, tilt the head and body at different angles to achieve the effect of clearing the respiratory tract, and then repeatedly confirm the user's breathing signal. If the breathing signal has returned to normal, follow the original oblique direction. Tilt the direction to allow the user to return to the initial sleep environment.

本發明提供之一種用於睡眠呼吸中止診療之床具組,一聲音接收模組,接收一使用者於一時間之一呼吸聲音訊號;一聲音處理模組,連接該聲音接收模組,由該呼吸聲音訊號之聲譜圖,取得一鼾聲訊號特徵;一資料庫,其係用以儲存複數氣道塌陷指數,以及該些氣道塌陷指數對應之一第一角度控制指令與一第二角度控制指令,其中,該些氣道塌陷指數係由複數呼吸狀態的鼾聲訊號特徵進行之分類;一控制模組,連接該聲音處理模組及該資料庫,比對該呼吸聲音訊號與該些呼吸狀態的鼾聲訊號特徵,選擇其一波形相同者所屬之氣道塌陷指數,並提供該氣道塌陷指數對應之該第一角度控制指令及該第二角度控制指令;一第一枕頭,其係連接該控制模組,係由一柔軟材料包覆一第一傾斜模組而成,使用時係置放於該使用者之頭部下方,待接收該第一角度控制指令後,朝一傾斜方向傾斜一第一角度;以及一第二枕頭,其係連接該控制模組,係由該柔軟材料包 覆一第二傾斜模組,使用時係置放於該使用者脖子及軀幹一側下方,待接收該第二角度控制指令後,朝一傾斜方向傾斜一第二角度。 The invention provides a bed set for sleep breathing treatment, a sound receiving module, receiving a breathing sound signal of a user at a time; a sound processing module connecting the sound receiving module, a sound spectrum of the respiratory sound signal to obtain a sound signal characteristic; a database for storing a plurality of airway collapse indices, and one of the first angle control commands and a second angle control command corresponding to the airway collapse index, The airway collapse index is classified by the characteristics of the squeaking signal of the plurality of breathing states; a control module is connected to the sound processing module and the database, and the snoring signal is compared with the breathing sound signal and the breathing states. Feature, selecting an airway collapse index to which the same waveform belongs, and providing the first angle control command and the second angle control command corresponding to the airway collapse index; a first pillow connected to the control module The first tilting module is covered by a soft material, and is placed under the head of the user when in use, to receive the first angle After the command system, a tilt direction towards a first angle; and a second pillow, which is connected to the control module based, packet-based soft material of the The second tilting module is placed under the side of the neck and the torso of the user. After receiving the second angle control command, the second tilting direction is inclined to a second angle.

較佳地,本發明所述之床具組中,該時間為包含,但不限於一呼吸動作中,一呼吸道軟組織的振動持續時間。 Preferably, in the bed set according to the present invention, the time is included, but not limited to, the duration of vibration of a respiratory soft tissue during a breathing action.

較佳地,本發明所述之床具組中,該聲音接收模組進一步使用,但不限於主成份分析法(Principal Component Analysis,PCA)過濾該呼吸訊號中的噪音。 Preferably, in the bed set of the present invention, the sound receiving module is further used, but is not limited to Principal Component Analysis (PCA) to filter noise in the breathing signal.

較佳地,本發明所述之床具組中,該些鼾聲訊號特徵係經由,但不限於短時距傅立葉轉換,並搭配高斯窗函數所取得之該呼吸聲音訊號以及該些呼吸狀態的聲譜圖諧波。 Preferably, in the bed set of the present invention, the sound signal characteristics are via, but not limited to, a short-time Fourier transform, and the breath sound signals obtained by the Gaussian window function and the sounds of the breathing states are obtained. Spectral harmonics.

較佳地,本發明所述之床具組中,更包含,一影像接收模組,接收該使用者於該時間之複數呼吸影像訊號;以及一影像處理模組,連接該影像接收模組,由該些呼吸影像訊號中相同之一呼吸道區域與一興趣區域,得到一氣道塌陷指數,其中,進一步,該一資料庫中,該些氣道塌陷指數係由該些呼吸狀態的鼾聲訊號特徵以及氣道塌陷指數進行的分類,則該控制模組連接該影像處理模組,比對該呼吸影像訊號與該些呼吸狀態的氣道塌陷指數,選擇其一聲音波形且影像分布相同者所屬之氣道塌陷指數,並提供該氣道塌陷指數對應之該第一角度控制指令及該第二角度控制指令。 Preferably, the bed set of the present invention further includes an image receiving module for receiving a plurality of respiratory image signals of the user at the time; and an image processing module connected to the image receiving module, An airway collapse index is obtained from the same respiratory region and an interest region in the respiratory image signals, wherein, further, in the database, the airway collapse index is characterized by the sound signal of the respiratory state and the airway According to the classification of the collapse index, the control module is connected to the image processing module, and the airway collapse index of the same sound waveform and the same image distribution is selected according to the respiratory image signal and the airway collapse index of the respiratory states. And providing the first angle control command and the second angle control command corresponding to the airway collapse index.

較佳地,本發明所述之床具組中,該影像接收模組進一步使用,但不限於自適應局部平均濾波器(adaptive partial averaging filter)增進該些呼吸影像訊號中的訊噪比。 Preferably, in the bed set of the present invention, the image receiving module is further used, but is not limited to an adaptive partial averaging filter to improve the signal to noise ratio in the respiratory image signals.

較佳地,本發明所述之床具組中,該些呼吸影像訊號係可為一矢狀視圖。 Preferably, in the bed set of the present invention, the respiratory image signals can be a sagittal view.

較佳地,本發明所述之床具組中,該些氣道塌陷指數係為該呼吸影像訊號以及該些呼吸狀態中,該呼吸道區域之面積相對於該興趣區域之面積的比例。 Preferably, in the bed set according to the present invention, the airway collapse index is the respiratory image signal and the ratio of the area of the respiratory region to the area of the region of interest in the respiratory states.

較佳地,本發明所述之床具組中,該呼吸道區域係由該興趣區域中,利用動態輪廓線模型(Active Contour Model,ACM)分割所取得。 Preferably, in the bed set according to the present invention, the airway region is obtained by segmentation of the region of interest using an Active Contour Model (ACM).

較佳地,本發明所述之床具組中,該控制模組進一步依該些呼吸影像訊號接收順序,取得複數時間參考點,並校正該鼾聲訊號特徵與該氣道塌陷指數的時間誤差。 Preferably, in the bed set of the present invention, the control module further obtains a plurality of time reference points according to the respiratory image receiving sequence, and corrects a time error of the click signal feature and the airway collapse index.

較佳地,本發明所述之床具組中,該第一枕頭與該第二枕頭可以平行於該使用者軀幹的方向為軸心,並向相同傾斜方向傾斜該第一角度及該第二角度。 Preferably, in the bed set of the present invention, the first pillow and the second pillow may be parallel to the direction of the user's torso and tilt the first angle and the second toward the same oblique direction. angle.

較佳地,本發明所述之床具組中,該第一角度及該第二角度可分別為任意角度,於最佳實施例中,其係15度、30度或60度其中之一。 Preferably, in the set of beds according to the present invention, the first angle and the second angle are respectively arbitrary angles, and in the preferred embodiment, they are one of 15 degrees, 30 degrees or 60 degrees.

較佳地,本發明所述之床具組中,該第一枕頭及該第二枕頭係相連接形成一L型枕頭。 Preferably, in the bed set of the present invention, the first pillow and the second pillow are connected to form an L-shaped pillow.

為了使任何熟習相關技藝者了解本發明之技術內容並據以實施,且根據本說明書所揭露之內容、申請專利範圍及圖式,任何熟習相關技藝者可輕易地理解本發明相關之目的及優點,因此將在實施方式中詳細敘述本發明之詳細特徵以及優點。 In order to make those skilled in the art understand the technical content of the present invention and implement it, and according to the disclosure, the patent scope and the drawings, the related objects and advantages of the present invention can be easily understood by those skilled in the art. The detailed features and advantages of the present invention will be described in detail in the embodiments.

100‧‧‧於睡眠呼吸中止診療之床具組 100‧‧‧ Bed set for sleep and treatment

110‧‧‧聲音接收模組 110‧‧‧Sound Receiver Module

120‧‧‧聲音處理模組 120‧‧‧Sound Processing Module

130‧‧‧資料庫 130‧‧‧Database

140‧‧‧控制模組 140‧‧‧Control Module

150‧‧‧第一枕頭 150‧‧‧First pillow

160‧‧‧第二枕頭 160‧‧‧ second pillow

170‧‧‧傾斜方向 170‧‧‧ oblique direction

180‧‧‧使用者 180‧‧‧Users

S200~S242‧‧‧避免睡眠呼吸中止的方法流程圖 S200~S242‧‧‧ Flowchart for avoiding sleep and breathing

第1圖為本發明睡眠呼吸中止診療之床具組實施例之一的示意圖;第2圖為本發明實施例之一種避免睡眠呼吸中止的方法流程圖;第3圖為本發明實施例之一種呼氣及吸氣之鼾聲訊號及其聲譜圖;第4圖為本發明實施例之一種鼾聲訊號及其聲譜圖;第5圖為第4圖之鼾聲訊號相對應之呼吸道動態影像及氣道塌陷指數;第6圖為本發明實施例之一種連續的呼吸聲音訊號聲譜圖及其氣道塌陷指數曲線圖;第7圖為本發明實施例之一種不同阻塞位置之氣道塌陷指數及鼾聲訊號特徵之關聯圖;以及第8圖為本發明實施例之一種不同阻塞位置之氣道塌陷指數及鼾聲訊號特徵之統計圖。 1 is a schematic view of one embodiment of a sleep breathing treatment bed set according to the present invention; FIG. 2 is a flow chart of a method for avoiding sleep breathing suspension according to an embodiment of the present invention; FIG. 3 is a schematic diagram of an embodiment of the present invention; Exhalation and inhalation squeak signal and its sonogram; Fig. 4 is a snoring signal and its sonogram of the embodiment of the invention; Fig. 5 is a respiratory tract dynamic image and airway corresponding to the humming signal of Fig. 4 Collapsing index; FIG. 6 is a continuous respiratory sound signal spectrum and its airway collapse index curve according to an embodiment of the present invention; FIG. 7 is an airway collapse index and squeaking signal characteristic of different blocking positions according to an embodiment of the present invention; Correlation diagram; and FIG. 8 is a statistical diagram of airway collapse index and squeak signal characteristics of different blocking positions according to an embodiment of the present invention.

為讓鈞院貴審查委員及習於此技術人士,對本發明之功效完全了解,茲配合圖示及圖號,就本發明較佳之實施例說明如下: In order to fully understand the effects of the present invention, the preferred embodiments of the present invention are described below with reference to the drawings and drawings.

如第1圖所示,本發明提供之一種用於睡眠呼吸中止診療之床具組100,一聲音接收模組110,接收一使用者180於一時間之一呼吸聲音訊號;該時間為一呼吸動作中,一呼吸道軟組織的振動持續時間。在一實施例中,該聲音接收模組進一步使用主成份分析法(Principal Component Analysis,PCA)過濾該呼吸訊號中的噪音 As shown in FIG. 1 , the present invention provides a bed set 100 for sleep breathing treatment, and a sound receiving module 110 receives a user 180 to breathe a sound signal at one time; the time is a breath. During the action, the vibration duration of a soft tissue of the respiratory tract. In one embodiment, the sound receiving module further filters the noise in the respiratory signal using Principal Component Analysis (PCA).

一聲音處理模組120,連接該聲音接收模組110,由該呼吸聲音訊號之聲譜圖,取得一鼾聲訊號特徵;在一實施例中,該些鼾聲訊號特徵係經由短時距傅立葉轉換,並搭配高斯窗函數所取得之該呼吸聲音訊號以及該些呼吸狀態的聲譜圖諧波。 A sound processing module 120 is connected to the sound receiving module 110, and obtains a sound signal characteristic from the sound spectrum of the breathing sound signal; in an embodiment, the sound signal characteristics are converted by short time Fourier transform. And the breathing sound signal obtained by the Gaussian window function and the spectrogram harmonics of the breathing states.

一資料庫130,其係用以儲存複數氣道塌陷指數,以及該些氣道塌陷指數對應之一第一角度控制指令與一第二角度控制指令,其中,該些氣道塌陷指數係由複數呼吸狀態的鼾聲訊號特徵進行之分類;一控制模組140,連接該聲音處理模組及該資料庫,比對該呼吸聲音訊號與該些呼吸狀態的鼾聲訊號特徵,選擇其一波形相同者所屬之氣道塌陷指數,並提供該氣道塌陷指數對應之該第一角度控制指令及該第二角度控制指令;一第一枕頭150,其係連接該控制模組,係由一柔軟材料包覆一第一傾斜模組而成,使用時係置放於該使用者180之頭部下方,待接收該第一角度控制指令後,朝一傾斜方向170傾斜一第一角度;以及一第二枕頭160,其係連接該控制模組140,係由該柔軟材料包覆一第二傾斜模組,使用時係置放於該使用者180脖子及軀幹一側下方,待接收該第二角度控制指令後,朝一傾斜方向170傾斜一第二角度。 a database 130 for storing a plurality of airway collapse indices, wherein the airway collapse indices correspond to one of a first angle control command and a second angle control command, wherein the airway collapse indices are caused by a plurality of respiratory states The sound signal feature is classified into a control module 140, and the sound processing module and the data library are connected, and the airway collapse of the same waveform is selected according to the breath sound signal and the sound signal characteristics of the respiratory states. Indexing, and providing the first angle control command and the second angle control command corresponding to the airway collapse index; a first pillow 150 connected to the control module, the first tilting die being covered by a soft material Formed, placed under the head of the user 180 after use, after receiving the first angle control command, tilting a first angle toward an oblique direction 170; and a second pillow 160 connecting the The control module 140 is coated with a second tilting module by the soft material, and is placed under the neck of the user 180 and below the side of the torso to be received. After the control instruction in the one oblique direction 170 inclined by a second angle.

該第一枕頭150與該第二枕頭160係以平行於該使用者180軀幹的方向為軸心,並向相同傾斜方向170傾斜該第一角度及該第二角度。於較佳實施例中,該第一角度及該第二角度可分別為15度、30度或60度其中之一。於較佳實施例中,該第一枕頭及該第二枕頭係相連接形成一L 型枕頭。 The first pillow 150 and the second pillow 160 are axially parallel to the direction of the torso of the user 180, and the first angle and the second angle are inclined in the same oblique direction 170. In a preferred embodiment, the first angle and the second angle may each be one of 15 degrees, 30 degrees, or 60 degrees. In a preferred embodiment, the first pillow and the second pillow are connected to form an L Pillows.

較佳地,本發明床具組100,更包含:一影像接收模組,接收該使用者於該時間之複數呼吸影像訊號;以及一影像處理模組,連接該影像接收模組,由該些呼吸影像訊號中相同之一呼吸道區域與一興趣區域,得到一氣道塌陷指數,其中,該資料庫130進一步將該些氣道塌陷指數係由該些呼吸狀態的鼾聲訊號特徵以及氣道塌陷指數進行的分類,則該控制模組連接該影像處理模組,比對該呼吸影像訊號與該些呼吸狀態的氣道塌陷指數,選擇其一聲音波形且影像分布相同者所屬之氣道塌陷指數,並提供該氣道塌陷指數對應之該第一角度控制指令及該第二角度控制指令。 Preferably, the bed set 100 of the present invention further comprises: an image receiving module for receiving the plurality of breath image signals of the user at the time; and an image processing module connected to the image receiving module, The same respiratory region and an region of interest in the respiratory image signal obtain an airway collapse index, wherein the database 130 further classifies the airway collapse index by the characteristics of the respiratory state and the airway collapse index. And the control module is connected to the image processing module, and selects an airway collapse index to which the sound waveform and the image distribution are the same as the airway collapse index of the respiratory image signal and the respiratory state, and provides the airway collapse The index corresponds to the first angle control command and the second angle control command.

在一實施例中,該影像接收模組進一步使用自適應局部平均濾波器(adaptive partial averaging filter)增進該些呼吸影像訊號中的訊噪比。於較佳實施例中,該些呼吸影像訊號係為一矢狀視圖。於較佳實施例中,該些氣道塌陷指數係為該呼吸影像訊號以及該些呼吸狀態中,該呼吸道區域之面積相對於該興趣區域之面積的比例。於較佳實施例中,該呼吸道區域係由該興趣區域中,利用動態輪廓線模型(Active Contour Model,ACM)分割所取得。於較佳實施例中,該控制模組進一步依該些呼吸影像訊號接收順序,取得複數時間參考點,並校正該鼾聲訊號特徵與該氣道塌陷指數的時間誤差。 In an embodiment, the image receiving module further uses an adaptive partial averaging filter to increase the signal to noise ratio of the respiratory image signals. In a preferred embodiment, the respiratory image signals are in a sagittal view. In a preferred embodiment, the airway collapse index is the ratio of the area of the airway region to the area of the region of interest in the respiratory image signal and the respiratory states. In a preferred embodiment, the airway region is obtained from the region of interest using an Active Contour Model (ACM) segmentation. In a preferred embodiment, the control module further obtains a plurality of time reference points according to the respiratory image signal receiving sequence, and corrects a time error of the click signal feature and the airway collapse index.

如第2圖所示,本發明提供一種避免睡眠呼吸中止的方法,其係透過本發明床具組100,包含以下步驟:使用者180平躺於前述床具組上方,其頭部係置放於一第一枕頭150之上方,而一第二枕頭160係置放於該使用者180脖子及軀幹一側下方S210;透過一聲音接收模組110,接收該使用者之一呼吸聲音訊號,並透過一聲音處理模組120,取得一鼾聲訊號特徵S220;由一控制模組140比對該呼吸聲音訊號與複數呼吸狀態的鼾聲訊號特徵,選擇其一波形相同者所屬之氣道塌陷指數,並提供該氣道塌陷指數對應之該第一角度控制指令及該第二角度控制指令S230;前述第一枕頭接收到前述第一角度控制指令後,依照前述傾斜方向170傾斜前述第一角度S241;以及前述第二枕頭接收到前述第二角度控制指令後,依照前述傾斜方向170傾斜前述第二角度S242。 As shown in Fig. 2, the present invention provides a method for avoiding sleep apnea, which is through the bed set 100 of the present invention, comprising the steps of: the user 180 lying flat above the bed set, the head being placed a second pillow 160 is placed on the neck 180 of the user 180 and below the trunk side S210; through a sound receiving module 110, one of the user's breathing signals is received, and A sound signal feature S220 is obtained through a sound processing module 120. A control module 140 selects an airway collapse index to which the same waveform belongs, by providing a sound signal characteristic of the respiratory sound signal and the plurality of respiratory states. The airway collapse index corresponds to the first angle control command and the second angle control command S230; after receiving the first angle control command, the first pillow tilts the first angle S241 according to the tilt direction 170; After receiving the second angle control command, the second pillow tilts the second angle S242 according to the tilt direction 170.

如第3圖所示,(a)圖為去噪後的鼾聲訊號,可以看到其中有不同形態的波動,且可區分出吸氣I以及呼氣E的部份。將鼾聲訊號經過短時距傅立葉轉換(short-time Fourier Transform)並搭配高斯窗函數(Gaussian sliding window)可以得到(b)圖所顯示之聲譜圖。其中,高斯窗函數的窗大小為0.1秒,兩個接續窗之間的位移為0.005秒。在(b)圖中可以看到H部分為諧波,F部分為基礎波,NH部分為非諧波。 As shown in Figure 3, (a) is a denoised click signal, which can be seen in different forms of fluctuations, and can distinguish between the inspiratory I and the exhalation E. The sound spectrum shown in (b) is obtained by subjecting the click signal to a short-time Fourier Transform and a Gaussian sliding window. The window size of the Gaussian window function is 0.1 second, and the displacement between the two successive windows is 0.005 seconds. In (b), it can be seen that the H part is a harmonic, the F part is a fundamental wave, and the NH part is a non-harmonic.

經發明人觀察,在睡眠時,受測者的肌肉張力降低而無法支撐上呼吸道的組織結構。當吸氣時,氣流經過上呼吸道之軟組織便震動軟組織而產生諧波(H部分),同時產生鼾聲,呼氣時則不會產生諧波(NH部分)。因此,可以從鼾聲訊號的聲譜圖中得知吸氣及呼氣的時間在哪以及鼾聲的持續時間。如此一來,鼾聲訊號特徵可以由聲譜圖中之諧波取得。諧波持續的時間也就是軟組織振動持續時間,可以被視為鼾聲訊號特徵。 It has been observed by the inventors that during sleep, the muscle tension of the subject is lowered to support the tissue structure of the upper respiratory tract. When inhaling, the airflow passes through the soft tissue of the upper respiratory tract and vibrates the soft tissue to generate harmonics (part H), while generating a squeak, and no exhalation produces harmonics (NH part). Therefore, the time of inhalation and exhalation and the duration of the snoring can be known from the spectrogram of the snoring signal. In this way, the beep signal feature can be obtained from the harmonics in the spectrogram. The duration of the harmonics, which is the duration of the soft tissue vibration, can be considered a squeak signal feature.

如第4圖及第5圖所示,在第4(a)圖中有一組鼾聲訊號,其聲譜圖為第4(b)圖,可以看到有諧波出現,諧波持續的時間也就是軟組織振動持續時間,同時有鼾聲出現,同樣地,H部分為諧波,F部分為基礎波。對照第5(a)圖至第5(f)圖,第5(a)圖為時間23.0秒,氣道塌陷指數為15.8%,第5(b)圖為時間23.5秒,氣道塌陷指數為9.8%,第5(c)圖為時間24.1秒,氣道塌陷指數為6.8%,而第5(d)圖為時間24.6秒,氣道塌陷指數為5.4%,第5(e)圖為時間25.1秒,氣道塌陷指數為10.3%,第5(f)圖為時間25.6秒,氣道塌陷指數為16.4%。由第5(a)圖至第5(c)圖可觀察到舌後區域漸漸塌陷,對照第4圖可發現是鼾聲響起的時間。到第5(d)圖時,吸氣達到尾聲,氣道塌陷指數降到最小,鼾聲結束。然後,第5(d)圖至第5(f)圖中,塌陷的氣道再度擴張,鼾聲結束而不會在聲譜圖中產生諧波。 As shown in Figures 4 and 5, there is a set of humming signals in Figure 4(a). The sound spectrum is in Figure 4(b). It can be seen that harmonics appear and the harmonics last for a long time. It is the duration of the soft tissue vibration, and there are buzzing sounds. Similarly, the H part is the harmonic and the F part is the fundamental wave. Referring to Figures 5(a) to 5(f), Figure 5(a) shows time 23.0 seconds, airway collapse index is 15.8%, picture 5(b) shows time 23.5 seconds, and airway collapse index is 9.8%. Figure 5(c) shows time 24.1 seconds, airway collapse index is 6.8%, and figure 5(d) shows time 24.6 seconds, airway collapse index is 5.4%, and figure 5(e) shows time 25.1 seconds. The collapse index was 10.3%, the 5th (f) chart was time 25.6 seconds, and the airway collapse index was 16.4%. From Fig. 5(a) to Fig. 5(c), it can be observed that the area behind the tongue gradually collapses, and it can be found from Fig. 4 that the buzzing sounds. By the time of the 5th (d) diagram, the inhalation reaches the end, the airway collapse index is minimized, and the snoring ends. Then, from the 5th (d)th to the 5th (f)th, the collapsed airway is expanded again, and the squeak ends without generating harmonics in the spectrogram.

如第6(a)圖所示,將連續的呼吸聲音訊號轉換為聲譜圖後,可辨別出吸氣I以及呼氣E的部份,且由有無諧波的產生,可進一步區分出鼾聲訊號,並界定出5個軟組織振動持續時間VTD,也就是鼾聲訊號特徵。再對照第6(b)圖,其係為錄製連續呼吸聲音訊號同時間多張動態影像中氣道塌陷指數計算結果的曲線圖,其中取樣頻率為0.5Hz,經由5個軟組織振動持續時間以及對應的動態影像、氣道塌陷指數,可觀察到氣道逐 漸變窄(氣道塌陷指數下降),約在25秒及30秒時,為兩個較嚴重的鼾聲事件,由影像上可觀察到為顎後及舌後綜合阻塞,此時氣道塌陷指數已低於10%,且軟組織振動持續時間較長,而在30至40秒時,舌後區域已完全塌陷阻塞,此時鼾聲停止。 As shown in Figure 6(a), after converting the continuous breathing sound signal into a sound spectrum, the part of the inhalation I and the exhalation E can be discerned, and the presence or absence of harmonics can further distinguish the buzzing sound. Signal, and define five soft tissue vibration durations VTD, which is the characteristics of the buzz signal. Referring to Figure 6(b), which is a graph of the calculation results of the airway collapse index in multiple dynamic images simultaneously recorded with continuous breathing sound signals, wherein the sampling frequency is 0.5 Hz, via 5 soft tissue vibration durations and corresponding Dynamic image, airway collapse index, airway can be observed The narrowing of the gradient (decreased airway collapse index) is about two more serious snoring events at about 25 seconds and 30 seconds. It can be observed that the posterior sacral and post-lingual obstruction is blocked. The airway collapse index is lower than this. 10%, and the soft tissue vibration lasts longer, and at 30 to 40 seconds, the back of the tongue has completely collapsed and blocked, and the snoring stops.

如第7圖所示,係將關聯資料庫的資料畫出之關聯圖,即可看出不同的阻塞位置具有不同的氣道塌陷指數及振動持續時間。又如第8圖所示,其統計圖可以看出氣道塌陷指數與振動持續時間皆顯著因不同的阻塞位置而有不同的數值區段,同時氣道塌陷指數與振動持續時間有關聯。由統計圖可看出,不同的呼吸睡眠中止之阻塞位置具有統計上顯著不同的氣道塌陷指數,例如純顎後阻塞具有氣道塌陷指數約24%±11%,而顎後及舌後綜合阻塞具有氣道塌陷指數約13%±7%[P0.0001]。因此,證明了可以使用關聯資料庫對應出與振動持續時間關聯的氣道塌陷指數,並依此判斷出睡眠呼吸中止之氣道塌陷位置。 As shown in Figure 7, the associated maps are drawn from the data of the associated database, and it can be seen that different blocking locations have different airway collapse indices and vibration durations. As shown in Fig. 8, the statistical graph shows that the airway collapse index and the vibration duration are significantly different due to different blocking positions, and the airway collapse index is related to the vibration duration. It can be seen from the statistics that the different respiratory sleep discontinuation has a statistically significant difference in airway collapse index. For example, the pure sputum occlusion has an airway collapse index of about 24% ± 11%, while the posterior and posterior lingual obstruction has Airway collapse index is about 13% ± 7% [P 0.0001]. Therefore, it is proved that the associated database can be used to correspond to the airway collapse index associated with the duration of vibration, and the position of the airway collapse in which sleep breathing is suspended can be determined accordingly.

惟上述各實施例係用以說明本發明之特點,其目的在使熟習該技術者能瞭解本發明之內容並據以實施,而非限定本發明之專利範圍,故凡其他未脫離本發明所揭示之精神而完成之等效修飾或修改,仍應包含在以下所述之申請專利範圍中。 The embodiments are described to illustrate the features of the present invention, and the purpose of the present invention is to enable those skilled in the art to understand the present invention and to implement the present invention without limiting the scope of the present invention. Equivalent modifications or modifications made by the spirit of the disclosure should still be included in the scope of the claims described below.

100‧‧‧用於睡眠呼吸中止診療之床具組 100‧‧‧Bed set for sleep and breathing treatment

110‧‧‧聲音接收模組 110‧‧‧Sound Receiver Module

120‧‧‧聲音處理模組 120‧‧‧Sound Processing Module

130‧‧‧資料庫 130‧‧‧Database

140‧‧‧控制模組 140‧‧‧Control Module

150‧‧‧第一枕頭 150‧‧‧First pillow

160‧‧‧第二枕頭 160‧‧‧ second pillow

170‧‧‧傾斜方向 170‧‧‧ oblique direction

180‧‧‧使用者 180‧‧‧Users

Claims (13)

一種用於睡眠呼吸中止診療之床具組,其包含:一聲音接收模組,接收一使用者於一時間之一呼吸聲音訊號;一聲音處理模組,連接該聲音接收模組,由該呼吸聲音訊號之聲譜圖,取得一鼾聲訊號特徵;一資料庫,其係用以儲存複數氣道塌陷指數,以及該些氣道塌陷指數對應之一第一角度控制指令與一第二角度控制指令,其中,該些氣道塌陷指數係由複數呼吸狀態的鼾聲訊號特徵進行之分類;一控制模組,連接該聲音處理模組及該資料庫,比對該呼吸聲音訊號與該些呼吸狀態的鼾聲訊號特徵,選擇其一波形相同者所屬之氣道塌陷指數,並提供該氣道塌陷指數對應之該第一角度控制指令及該第二角度控制指令;一第一枕頭,其係連接該控制模組,係由一柔軟材料包覆一第一傾斜模組而成,使用時係置放於該使用者之頭部下方,待接收該第一角度控制指令後,朝一傾斜方向傾斜一第一角度;以及一第二枕頭,其係連接該控制模組,係由該柔軟材料包覆一第二傾斜模組,使用時係置放於該使用者脖子及軀幹一側下方,待接收該第二角度控制指令後,朝一傾斜方向傾斜一第二角度。 A bed set for sleep breathing treatment includes: a sound receiving module for receiving a breathing sound signal of a user at a time; a sound processing module connecting the sound receiving module by the breathing a sound spectrum of the sound signal, obtaining a sound signal characteristic; a database for storing a plurality of airway collapse indexes, and the airway collapse index corresponding to the first angle control command and a second angle control command, wherein The airway collapse index is classified by the characteristics of the snoring signal of the plurality of breathing states; a control module is connected to the sound processing module and the database, and the breathing signal and the snoring signal characteristics of the breathing states are compared Selecting an airway collapse index to which the same waveform belongs, and providing the first angle control command corresponding to the airway collapse index and the second angle control command; a first pillow connected to the control module a soft material is coated with a first tilting module, and is placed under the head of the user when in use, to receive the first angle control Afterwards, tilting a first angle toward an oblique direction; and a second pillow connected to the control module, the second tilting module is covered by the soft material, and is placed on the user's neck when in use And below the side of the torso, after receiving the second angle control command, tilting a second angle toward an oblique direction. 如申請專利範圍第1項所述之床具組,其中,該時間為一呼吸動作中,一呼吸道軟組織的振動持續時間。 The bed set according to claim 1, wherein the time is a vibration duration of a respiratory soft tissue in a breathing action. 如申請專利範圍第1項所述之床具組,其中,該聲音接收模組進一步使用主成份分析法(Principal Component Analysis,PCA)過濾該呼吸訊號中的噪音。 The bed set according to claim 1, wherein the sound receiving module further filters the noise in the breathing signal using Principal Component Analysis (PCA). 如申請專利範圍第1項所述之床具組,其中,該些鼾聲訊號特徵係經由短時距傅立葉轉換,並搭配高斯窗函數所取得之該呼吸聲音訊號以及該些呼吸狀態的聲譜圖諧波。 The bed set according to claim 1, wherein the click signal characteristics are converted by a short time Fourier transform, and the breath sound signal obtained by the Gaussian window function and the sound spectrum of the respiratory states are obtained. harmonic. 如申請專利範圍第2項所述之床具組,更包含:一影像接收模組,接收該使用者於該時間之複數呼吸影像訊號;以及 一影像處理模組,連接該影像接收模組,由該些呼吸影像訊號中相同之一呼吸道區域與一興趣區域,得到一氣道塌陷指數,其中,;進一步,該一資料庫中,該些氣道塌陷指數係由該些呼吸狀態的鼾聲訊號特徵以及氣道塌陷指數進行的分類,則該控制模組連接該影像處理模組,比對該呼吸影像訊號與該些呼吸狀態的氣道塌陷指數,選擇其一聲音波形且影像分布相同者所屬之氣道塌陷指數,並提供該氣道塌陷指數對應之該第一角度控制指令及該第二角度控制指令。 The bed set according to claim 2, further comprising: an image receiving module, receiving the plurality of respiratory image signals of the user at the time; An image processing module is connected to the image receiving module to obtain an airway collapse index from the same one of the respiratory image signals and an interest region, wherein, further, the air channels in the database The collapse index is classified by the snoring signal characteristics of the respiratory states and the airway collapse index, and the control module is connected to the image processing module, and selects the respiratory imaging signal and the airway collapse index of the respiratory states. An airway collapse index to which the sound waveform and the image distribution are the same, and the first angle control command corresponding to the airway collapse index and the second angle control command are provided. 如申請專利範圍第5項所述之床具組,其中,該影像接收模組進一步使用自適應局部平均濾波器(adaptive partial averaging filter)增進該些呼吸影像訊號中的訊噪比。 The bed set according to claim 5, wherein the image receiving module further uses an adaptive partial averaging filter to increase a signal to noise ratio in the respiratory image signals. 如申請專利範圍第6項所述之床具組,其中,該些呼吸影像訊號係為一矢狀視圖。 The bed set according to claim 6, wherein the respiratory image signals are in a sagittal view. 如申請專利範圍第5項所述之床具組,其中,該些氣道塌陷指數係為該呼吸影像訊號以及該些呼吸狀態中,該呼吸道區域之面積相對於該興趣區域之面積的比例。 The bed set according to claim 5, wherein the airway collapse index is the respiratory image signal and a ratio of an area of the respiratory region to an area of the region of interest in the respiratory states. 如申請專利範圍第8項所述之床具組,其中,該呼吸道區域係由該興趣區域中,利用動態輪廓線模型(Active Contour Model,ACM)分割所取得。 The bed set according to claim 8, wherein the airway region is obtained by using an Active Contour Model (ACM) segmentation in the region of interest. 如申請專利範圍第5項所述之床具組,其中,該控制模組進一步依該些呼吸影像訊號接收順序,取得複數時間參考點,並校正該鼾聲訊號特徵與該氣道塌陷指數的時間誤差。 The bed set according to claim 5, wherein the control module further obtains a plurality of time reference points according to the respiratory image receiving sequence, and corrects a time error of the click signal characteristic and the airway collapse index . 如申請專利範圍第1項所述之床具組,其中,該第一枕頭與該第二枕頭係以平行於該使用者軀幹的方向為軸心,並向相同傾斜方向傾斜該第一角度及該第二角度。 The bed set according to claim 1, wherein the first pillow and the second pillow are axially parallel to a direction of the user's torso, and the first angle is inclined in the same oblique direction and The second angle. 如申請專利範圍第1項所述之床具組,其中,該第一角度及該第二角度可分別為15度、30度或60度其中之一。 The bed set according to claim 1, wherein the first angle and the second angle are respectively one of 15 degrees, 30 degrees or 60 degrees. 如申請專利範圍第1項所述之床具組,其中,該第一枕頭及該第二枕頭係相連接形成一L型枕頭。 The bed set according to claim 1, wherein the first pillow and the second pillow are connected to form an L-shaped pillow.
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