TW201718569A - Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto - Google Patents

Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto Download PDF

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TW201718569A
TW201718569A TW105128408A TW105128408A TW201718569A TW 201718569 A TW201718569 A TW 201718569A TW 105128408 A TW105128408 A TW 105128408A TW 105128408 A TW105128408 A TW 105128408A TW 201718569 A TW201718569 A TW 201718569A
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娜塔莉 C. 詹派特羅
蓋瑞 D. 克羅斯
湯瑪斯 C. 史帕克斯
大衛 A. 德莫特爾
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陶氏農業科學公司
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Abstract

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula ("Formula One").

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具有殺蟲效用之分子以及與其相關之中間物、組成物及方法(一)Molecules with insecticidal effects and related intermediates, compositions and methods (1)

發明領域 此揭露內容係有關於下列領域：具有對抗節肢動物門、軟體動物門，及圓形動物門之害蟲之殺蟲效用的分子，生產此類分子之方法、使用於此類方法中之中間物、含有此等分子之殺蟲組成物，以及使用此等殺蟲分子對抗此種害蟲之方法。這些殺蟲組成物可使用作為舉例而言，殺蜱蟎劑、殺昆蟲劑、殺蟎劑、殺軟體動物劑，及殺線蟲劑。FIELD OF THE INVENTION This disclosure relates to the following fields: molecules having insecticidal effects against arthropods, mollusc doors, and pests of round animal gates, methods of producing such molecules, used in the middle of such methods Materials, insecticidal compositions containing such molecules, and methods of using such insecticidal molecules against such pests. These insecticidal compositions can be used, for example, as acaricides, insecticides, acaricides, molluscicides, and nematicides.

發明背景 “有許多最危險的人類疾病是由昆蟲媒介傳播的”(Rivero等人)。由歷史上來看，瘧疾、登革熱、黃熱病、鼠疫、絲蟲病、蝨傳斑疹傷寒、錐蟲病(trypanosomiasis)、萊什曼病(leishmaniasis)和其他病媒感染疾病，較其他原因引起更多的人類疾病與死亡，自17至20世紀初期(Gubler)。病媒感染疾病佔全球寄生蟲病與傳染病約17%。僅僅瘧疾每年便造成超過800,000人死亡，這些死亡者有85%為五歲以下之孩童。每年約有五千萬至一億件案例之登革熱出血。每年發生另外的250,000至500,000件案例之登革熱出血(Matthews)。病媒防治在預防與控制感染性疾病方面扮演相當重要的角色。然而，殺蟲劑抗性包括多重殺蟲劑抗性，在人類疾病主要病媒之所有昆蟲物種上愈來愈嚴重(Rivero等人)。近來，超過550個節肢動物物種業已發展出對至少一種害蟲之抗性(Whalon等人)。再者，昆蟲抗性的個案顯然不斷地超越除草劑及殺真菌劑抗性個案的數目(Sparks等人)。BACKGROUND OF THE INVENTION "There are many of the most dangerous human diseases that are transmitted by insect vectors" (Rivero et al.). Historically, malaria, dengue fever, yellow fever, plague, filariasis, typhus typhus, trypanosomiasis, leishmaniasis, and other vector-borne diseases have been caused by other causes. Many human diseases and deaths, from the early 17th to the early 20th century (Gubler). Vector-borne diseases account for about 17% of global parasitic diseases and infectious diseases. Only malaria causes more than 800,000 deaths each year, and 85% of these deaths are children under the age of five. There are about 50 to 100 million cases of dengue hemorrhage each year. An additional 250,000 to 500,000 cases of dengue hemorrhage (Matthews) occur each year. Vector control plays a very important role in the prevention and control of infectious diseases. However, insecticide resistance, including multiple insecticide resistance, is becoming more severe in all insect species of the main vector of human disease (Rivero et al.). Recently, more than 550 arthropod species have developed resistance to at least one pest (Whalon et al.). Furthermore, cases of insect resistance clearly continue to exceed the number of herbicide and fungicide resistant cases (Sparks et al.).

每年昆蟲、植物病原體與雜草破壞了所有潛在食物生產量之40%。儘管施用殺蟲劑及使用一系列廣泛的非化學控制，諸如輪作及生物控制，但此損失仍存在。若僅可保存此食物中的一些，便可用於供養世界上超過三十億營養不良的人口(Pimental)。Every year, insects, plant pathogens and weeds destroy 40% of all potential food production. Despite the application of pesticides and the use of a wide range of non-chemical controls, such as crop rotation and biological control, this loss still exists. If only some of this food can be preserved, it can be used to feed more than three billion malnourished people (Pimental) in the world.

植物寄生線蟲為分佈最廣的害蟲之一，且常常為最隱伏及代價高的害蟲之一。據估計，由於線蟲造成之損失，在已開發國家為約9%，在未開發國家為約15%。然而，在美國，根據35個州對於各種作物之調查顯示，線蟲衍生之損失高達25%(Nicol等人)。Plant parasitic nematodes are among the most widely distributed pests and are often one of the most insidious and costly pests. It is estimated that the losses caused by nematodes are about 9% in developed countries and about 15% in undeveloped countries. However, in the United States, according to a survey of various crops in 35 states, nematode-derived losses are as high as 25% (Nicol et al.).

值得注意的是，腹足類（蛞蝓和蝸牛為經濟重要性低於其他的節肢動物或線蟲少的害蟲，但在某些地方，腹足類可能會實質上大量降低產率，嚴重影響收穫產品的品質，以及會傳播人類、動物及植物疾病。雖然只有幾十種腹足類是嚴重地區性害蟲，但有少數品種是世界範圍內的重要害蟲。特別是，腹足類影響廣泛多種農業和園藝作物，如耕地、牧場、和纖維作物；蔬菜；灌木和喬木果實；草本植物；以及觀賞植物(Speiser)。It is worth noting that gastropods (scorpions and snails are less economically important than other arthropods or nematodes), but in some places, gastropods may substantially reduce yields substantially, seriously affecting the quality of harvested products, and It spreads human, animal and plant diseases. Although only a few dozen gastropods are serious regional pests, there are a few species that are important pests worldwide. In particular, gastropods affect a wide variety of agricultural and horticultural crops, such as cultivated land and pasture. And fiber crops; vegetables; shrubs and arbor fruits; herbaceous plants; and ornamental plants (Speiser).

白蟻會造成各種私人和公共建築，以及農業和林業資源損害。據估計，在2005年，白蟻造成每年全世界損失超過500億美元(Korb)。Termites can cause damage to a variety of private and public buildings, as well as agricultural and forestry resources. It is estimated that in 2005, termites caused more than $50 billion in worldwide losses per year (Korb).

因此，就許多理由，包括上述之該等理由，持續需要昂貴的(估計於2010年每害蟲為大約25億6千萬美元)、耗時的(每害蟲平均為大約10年)，以及困難開發的新穎殺蟲劑(CropLife America)。在本揭露內容中所引用的某些參考文獻 Therefore, for many reasons, including those mentioned above, there is a continuing need for expensive (estimated at approximately $2.56 billion per pest in 2010), time consuming (average about 10 years per pest), and difficult development Novel insecticide (CropLife America). Certain references cited in this disclosure

CropLife America, The Cost of New Agrochemical Product Discovery, Development & Registration, and Research & Development predictions for the Future, 2010. Drewes, M., Tietjen, K., Sparks, T.C., High–Throughput Screening in Agrochemical Research,Modern Methods in Crop Protection Research , Part I,Methods for the Design and Optimization of New Active Ingredients , Edited by Jeschke, P., Kramer, W., Schirmer, U., and Matthias W., p. 1–20, 2012. Gubler, D., Resurgent Vector–Borne Diseases as a Global Health Problem, Emerging Infectious Diseases, Vol. 4, No. 3, p. 442–450, 1998. Korb, J., Termites, Current Biology, Vol. 17, No. 23, 2007. Matthews, G., Integrated Vector Management: Controlling Vectors of Malaria and Other Insect Vector Borne Diseases, Ch. 1, p. 1, 2011. Nicol, J., Turner S., Coyne, L., den Nijs, L., Hocksland, L., Tahna–Maafi, Z., Current Nematode Threats to World Agriculture,Genomic and Molecular Genetics of Plant – Nematode Interactions , p. 21–43, 2011. Pimental, D., Pest Control in World Agriculture,Agricultural Sciences – Vol. II, 2009. Rivero, A., Vezilier, J., Weill, M., Read, A., Gandon, S., Insect Control of Vector–Borne Diseases: When is Insect Resistance a Problem?Public Library of Science Pathogens, Vol. 6, No. 8, p. 1–9, 2010. Sparks T.C., Nauen R., IRAC: Mode of action classification and insecticide resistance management,Pesticide Biochemistry and Physiology (2014) available online 4 December 2014. Speiser, B., Molluscicides,Encyclopedia of Pest Management , Ch. 219, p. 506–508, 2002. Whalon, M., Mota–Sanchez, D., Hollingworth, R., Analysis of Global Pesticide Resistance in Arthropods,Global Pesticide Resistance in Arthropods , Ch. 1, p. 5–33, 2008.CropLife America, The Cost of New Agrochemical Product Discovery, Development & Registration, and Research & Development predictions for the Future, 2010. Drewes, M., Tietjen, K., Sparks, TC, High–Throughput Screening in Agrochemical Research, Modern Methods In Crop Protection Research , Part I, Methods for the Design and Optimization of New Active Ingredients , Edited by Jeschke, P., Kramer, W., Schirmer, U., and Matthias W., p. 1–20, 2012. Gubler , D., Resurgent Vector–Borne Diseases as a Global Health Problem, Emerging Infectious Diseases, Vol. 4, No. 3, p. 442–450, 1998. Korb, J., Termites, Current Biology, Vol. 17, No 23, 2007. Matthews, G., Integrated Vector Management: Controlling Vectors of Malaria and Other Insect Vector Borne Diseases, Ch. 1, p. 1, 2011. Nicol, J., Turner S., Coyne, L., den Nijs, L., Hocksland, L., Tahna–Maafi, Z., Current Nematode Threats to World Agriculture, Genomic and Molecular Genetics of Plant – Nematode Interactions , p. 21–43, 2011. Pim Ental, D., Pest Control in World Agriculture, Agricultural Sciences – Vol. II, 2009. Rivero, A., Vezilier, J., Weill, M., Read, A., Gandon, S., Insect Control of Vector– Borne Diseases: When is Insect Resistance a Problem? Public Library of Science Pathogens, Vol. 6, No. 8, p. 1–9, 2010. Sparks TC, Nauen R., IRAC: Mode of action classification and insecticide resistance management, Pesticide Biochemistry and Physiology (2014) available online 4 December 2014. Speiser, B., Molluscicides, Encyclopedia of Pest Management , Ch. 219, p. 506–508, 2002. Whalon, M., Mota–Sanchez, D., Hollingworth , R., Analysis of Global Pesticide Resistance in Arthropods, Global Pesticide Resistance in Arthropods , Ch. 1, p. 5–33, 2008.

依據本發明之一實施例，係特地提出一種具下式之分子 式1 其中：(A)       Ar1 係選自於下列所構成的群組：呋喃基、苯基、嗒基、吡啶基、嘧啶基，或是噻吩基， 其中每個呋喃基、苯基、嗒基、吡啶基、嘧啶基，及噻吩基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(B)       Het 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子，以及其中Ar1 與L1 互相不為鄰位，但可為間位或對位，例如就5員環而言，其等為1,3，且就6員環而言，其等為1,3或1,4， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(C)       L1 係選自於下列所構成的群組：(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基，以及(C2 -C6 )炔基， 其中每個烷基、鹵烷基、環烷基、烯基及炔基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基，以及(C2 -C6 )炔基；(D)       Ar2 係選自於下列所構成的群組：呋喃基、苯基、嗒基、吡啶基、嘧啶基，或是噻吩基， 其中每個呋喃基、苯基、嗒基、吡啶基、嘧啶基，及噻吩基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(E) R15 係選自於下列所構成的群組：H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、C(O)-NRx Ry 、C(O)-苯基、(C1 -C4 )烷基-NRx Ry 、C(O)O-(C1 -C4 )烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基，以及(C1 -C4 )烷基-OC(=O)O-(C1 -C4 )烷基， 其中每個烷基、環烷基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(F) Q1 係選自於O及S所構成的群組；(G)Q2 係選自於O及S所構成的群組；(H) R16 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基)、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(I) R17 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(J) L2 係選自於下列所構成的群組：(C3 -C8 )環烷基、苯基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、(C2 -C6 )烯基-O-苯基、(Het-1)、(C1 -C4 )烷基-(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)；(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起形成一個4-至7-員飽和或不飽和之烴基環(hydrocarbyl cyclic)基團，其可以進一步含有選自於氮、硫或氧所構成的群組之一個或更多個雜原子， 其中該烴基環基團可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：側氧、R18 及R19 ， 其中R18 及R19 係各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、側氧、硫酮基、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(L) Rx 及Ry 係各自獨立地選自於下列所構成的群組：H、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基，以及苯基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(M)      (Het-1) 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(N) n 每一者係獨立地為0、1或2；以及式1的分子之N-氧化物、農業上可接受的酸加成鹽類、鹽類衍生物、溶劑合物、結晶性多形體、同位素、解析的立體異構物，以及互變異構物。According to an embodiment of the present invention, a molecule having the following formula is specifically proposed Formula 1 wherein: (A) Ar 1 is selected from the following group consisting of: furyl, phenyl, despair a pyridyl group, a pyrimidinyl group, or a thienyl group, wherein each furanyl group, phenyl group, hydrazine group The base, pyridyl, pyrimidinyl, and thienyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 - C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n - (C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-( C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-( C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl -O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 An alkyl-C(O)O-(C 1 -C 4 )alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group Alkenyl, alkynyl, phenyl, and phenoxy substituted May be selectively one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkoxy , (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C (O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C (O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkane , (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-( C 1 -C 4 )alkyl, phenyl, and phenoxy; (B) Het is a 5 or 6 membered, saturated or unsaturated heterocyclic ring containing one or more independently selected from nitrogen, sulfur or oxygen. heteroatoms, and wherein each Ar 1 to L 1 is not a position, but may be a meta or a para position, for example, for a 5-membered ring, it is 1, 3, and in the case of a 6-membered ring, it is 1, 3 or 1, 4, wherein each heterocyclic ring It may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C) 4 ) an alkyl group, a (C 1 -C 4 )haloalkyl group, a (C 3 -C 8 )cycloalkyl group, a (C 1 -C 4 )alkoxy group, a (C 1 -C 4 )halo alkoxy group, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )halide Alkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl- NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )halane , C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkane , C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O) O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkane The group, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, phenyl, and phenoxy substituents may be optionally independently selected from one or more of the following The substituents of the group formed are substituted: H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl , S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 - (C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl , C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C( O) O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy (C) L 1 is selected from the group consisting of: (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, and (C 2 -C 6 )alkynyl, Wherein each alkyl, haloalkyl, cycloalkyl, alkenyl and alkynyl group may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 ) Alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, and (C 2 -C 6 )alkynyl; (D) Ar 2 is selected from the following Group: furyl, phenyl, hydrazine a pyridyl group, a pyrimidinyl group, or a thienyl group, wherein each furanyl group, phenyl group, hydrazine group The base, pyridyl, pyrimidinyl, and thienyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 - C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n - (C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-( C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-( C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl -O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 An alkyl-C(O)O-(C 1 -C 4 )alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group Alkenyl, alkynyl, phenyl, and phenoxy substituted May be selectively one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkoxy , (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C (O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C (O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkane , (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O)O- (C 1 -C 4 )alkyl, phenyl, and phenoxy; (E) R 15 is selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 3 - C 8) cycloalkyl, (C 2 -C 6) alkenyl, (C 2 -C 6) alkynyl group, S (O) n - ( C 1 -C 4) alkoxy , C (O) -NR x R y, C (O) - phenyl, (C 1 -C 4) alkyl group -NR x R y, C (O ) O- (C 1 -C 4) alkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C( O) O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O) -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, and (C 1 -C 4 )alkyl-OC ( =O)O-(C 1 -C 4 )alkyl, wherein each alkyl, cycloalkyl, alkenyl, alkynyl, and phenyl group may be optionally independently selected from one or more of the following The substituents of the group formed are substituted: H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 Alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 Alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 ) alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O)O-(C 1 -C 4 ) alkyl, phenyl, and phenoxy; (F) Q 1 is selected from O and S in the group consisting of; (G) Q 2 is selected from O and S in the group consisting of; (H) R 16 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, C(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, C(O)-(Het-1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-C(O)-(Het-1) (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (NR x R y )-C(O)OH, (C 1 -C 4 ) Alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-NR x R y ,(C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-C(O)-N(R x ) (C 1 -C 4 )alkyl (N(R x )-C(O)O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 )alkyl-C (O)-(Het-1)-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 ) alkane (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3 -C 8 ) ring Alkyl, (C 1 -C 4 )alkyl-OC(O)-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl-N (R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl-S(O) n -(Het-1), and (C 1 -C 4 )alkyl-O-(Het-1), wherein each alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, and (Het- 1) may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , NR x R y , ( C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(=O) n -(C 1 -C 4 )alkyl, S ( =O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H,C (O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-( C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 - C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl), phenyl, phenoxy, Si ((C 1 -C 4 )alkyl) 3 , S(=O) n -NR x R y , and (Het-1); (I) R 17 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl,C(O)-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 Alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, C(O)-(Het -1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, ( C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl- (Het-1), (C 1 -C 4 )alkyl-C(O)-(Het-1), (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (NR x R y )-C(O)OH, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl(N(R x )-C(O)O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 )alkyl-C(O)-(Het-1)-C(O)O-(C 1 -C 4 ) alkane (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 ) Alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkyl-OC(O)-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl-S(O) n -(Het-1), and (C 1 -C 4 )alkyl-O-(He T-1), wherein each alkyl group, cycloalkyl group, alkenyl group, alkynyl group, phenyl group, and (Het-1) may be optionally selected from the group consisting of one or more independently selected from the group consisting of Substituents of the group are substituted: H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3- C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(=O) n -(C 1 -C 4 )alkyl, S(=O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )halane Base, C(O)H, C(O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 Alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )halide Alkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl , C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S (O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, benzene Oxy, Si((C 1 -C 4 )alkyl) 3 , S(=O) n -NR x R y , and (Het-1); (J) L 2 is selected from Group consisting of (C 3 -C 8 )cycloalkyl, phenyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, (C 2 -C 6 )alkenyl-O-phenyl, (Het-1), (C 1 -C 4 )alkyl-(Het-1), and (C 1 -C 4 )alkyl-O-(Het And -1), wherein each alkyl group, cycloalkyl group, alkenyl group, phenyl group, and (Het-1) may be optionally one or more substituents independently selected from the group consisting of the following: Substituted: H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 a cycloalkyl group, a (C 1 -C 4 ) alkoxy group, a (C 1 -C 4 )haloalkoxy group, a (C 2 -C 6 )alkenyl group, a (C 2 -C 6 )alkynyl group, S ( O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 ) haloalkyl, C(O)H, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 Alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )halide Alkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl , C(O)O-(C 2 -C 6 )alkenyl, O-(C 1 -C 4 )alkyl, S- (C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O O-(C 1 -C 4 )alkyl, phenyl, phenoxy, and (Het-1), wherein each alkyl, cycloalkyl, alkenyl, phenyl, and (Het-1) substitution The group may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )halane Oxyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 ) haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-NR x R y , ( C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)- (C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O- (C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, O-(C 1 -C 4 Alkyl, S-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, C ( O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, phenoxy, and (Het-1); (K) R 16 and R 17 together with C x (Q 2 )(N x ) forms a 4- to 7-membered saturated or unsaturated hydrocarbyl cyclic group, which may further comprise a compound selected from the group consisting of nitrogen, sulfur or oxygen. One or more heteroatoms of the group, wherein the hydrocarbyl ring group may be optionally substituted with one or more substituents independently selected from the group consisting of: side oxygen, R 18 and R 19 , wherein R 18 and R 19 are each independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, thioketone, (C 1 -C) 4 ) an alkyl group, a (C 1 -C 4 )haloalkyl group, a (C 3 -C 8 )cycloalkyl group, a (C 1 -C 4 )alkoxy group, a (C 1 -C 4 )halo alkoxy group, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )halide Alkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-(C 1 -C 4 )alkyl , C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C (O) - (C 3 -C 8) Alkyl, C (O) O- (C 3 -C 8) cycloalkyl, C (O) - (C 2 -C 6) alkenyl, C (O) O- (C 2 -C 6) alkenyl (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C (O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and (Het-1); (L) R x and R y each Independently selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 - C 4 ) alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 ) alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C (O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )halane , C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkane , C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O) O- (C 1 -C 4) alkyl, and phenyl, wherein each alkyl, haloalkyl The cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, and phenyl groups may be optionally substituted with one or more substituents independently selected from the group consisting of: H , F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 - C 4 ) alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 ) alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C (O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )halane , C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkane , C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O) O-(C 1 -C 4 )alkyl, phenyl, and (Het-1); (M) (Het-1) is a 5- or 6-membered, saturated or unsaturated heterocyclic ring containing independently selected from One or more heteroatoms of nitrogen, sulfur or oxygen, of which Heterocyclyl may optionally be one or more substituents independently selected from the group consisting of the substituent group to be substituted with the following: 2, the oxygen side H, F, Cl, Br, I, CN, NO, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )halane Oxyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 ) haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 ) Alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 Haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 a cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C (O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkyne a base, a phenyl group, and a phenoxy substituent may be optionally One or more substituents independently selected from the group consisting of the group to be substituted with the following: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkyl, (C 1 -C 4 ) haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 ) alkene , (C 2 -C 6 ) alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O )-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O- (C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-( C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 An alkyl group, a phenyl group, and a phenoxy group; (N) n each independently being 0, 1 or 2; and a molecular N-oxide of the formula 1, an agriculturally acceptable acid addition salt , salt derivatives, solvates, crystalline polymorphs, isotopes Resolved stereoisomers, and tautomers thereof.

在本揭露內容中所使用的定義 在此等定義中所提供之範例一般而言並非非窮舉性的，且不得解釋為限制本揭露內容。應理解，取代基應依從與其所連接的特定分子相關之化學鍵結規則及立體相容性的限制。此等定義僅用於本揭露內容的目的。 The definitions used in the disclosure are generally not to be construed as limiting the disclosure. It will be understood that the substituents should be subject to the chemical bonding rules and stereo compatibility limitations associated with the particular molecule to which they are attached. These definitions are for the sole purpose of the disclosure.

用語「活性成分 」係意指一種材料，其具有控制害蟲有用的活性，及/或其有用於協助其他材料有更好的控制害蟲之活性，此等材料的實例包括但不限於：殺蜱蟎劑、除藻劑、拒食劑、殺鳥劑(avicide)、殺菌劑、驅鳥劑、化學絕育劑、殺真菌劑、除草劑安全劑、除草劑、誘蟲劑、驅蟲劑、殺昆蟲劑、驅哺乳動物劑、交配干擾劑、殺蟎劑、殺線蟲劑、植物活化劑、植物生長調節劑、滅鼠劑、協力劑，以及殺病毒劑(見alanwood.net)。此等材料的特定實例包括但不限於活性成分群組α之中列出的材料。The term " active ingredient " means a material which has activity useful in controlling pests and/or which has activity for assisting other materials to better control pests, examples of which include, but are not limited to, killing Agent, algaecide, antifeedant, avicide, fungicide, bird repellent, chemical sterilization agent, fungicide, herbicide safener, herbicide, insect attractant, insect repellent, insecticide , mammalian agents, mating interferers, acaricides, nematicides, plant activators, plant growth regulators, rodenticides, synergists, and virucides (see alanwood.net). Specific examples of such materials include, but are not limited to, those listed in the active ingredient group a.

用語「活性成分 群 組α 」(此後稱為“AIGA ”)」係集體意指下列材料：(1) (3-乙氧基丙基)溴化汞、1,2-二溴乙烷、1,2-二氯乙烷、1,2-二氯丙烷、1,3-二氯丙烯、1-MCP、1-甲基環丙烯、1-萘酚、2-(辛基硫基)乙醇、2,3,3-TPA、2,3,5-三碘苯甲酸、2,3,6-TBA、2,4,5-T、2,4,5-TB、2,4,5-TP、2,4-D、2,4-DB、2,4-DEB、2,4-DEP、2,4-DES、2,4-DP、2,4-MCPA、2,4-MCPB、2iP、2-甲氧基乙基氯化汞、2-苯基酚、3,4-DA、3,4-DB、3,4-DP、3,6-二氯2-吡啶甲酸、4-胺基吡啶、4-CPA、4-CPB、4-CPP、4-羥基苯乙基醇、8-羥基喹啉硫酸鹽、8-苯基汞氧基喹啉、阿巴美丁(abamectin)、阿巴美丁胺甲基(abamectin-aminomethyl)、脫落酸(abscisic acid)、ACC、毆殺松(acephate)、亞醌蟎(acequinocyl)、亞滅培(acetamiprid)、家蠅磷(acethion)、乙草胺(acetochlor)、三氯殺蟲酯(acetofenate)、乙酯磷(acetophos)、乙醯蟲腈(acetoprole)、阿拉酸式苯(acibenzolar)、亞喜芬(acifluorfen)、苯草醚(aclonifen)、CAN、內醯吖庚胺(acrep)、阿納寧(acrinathrin)、丙烯醛(acrolein)、丙烯腈、阿西佩它克斯(acypetacs)、阿斐多匹朋(afidopyropen)、阿福藍(afoxolaner)、拉草(alachlor)、鈉得爛(alanap)、棉鈴威(alanycarb)、阿苯達唑(albendazole)、得滅克(aldicarb)、得滅克碸、十二嗎啉(aldimorph)、涕滅碸威(aldoxycarb)、阿特靈(aldrin)、亞列寧(allethrin)、蒜素(allicin)、草毒死(allidochlor)、阿洛胺菌素(allosamidin)、亞汰草(alloxydim)、烯丙醇、除害威(allyxycarb)、亞羅列克(alorac)、α-賽滅寧(alpha -cypermethrin)、α-安殺番(alpha -endosulfan)、亞滅寧(alphamethrin)、六甲嘧胺(altretamine)、磷化鋁(aluminium phosphide)、磷化鋁(aluminum phosphide)、辛唑嘧菌胺(ametoctradin)、特津酮(ametridione)、草殺淨(ametryn)、草殺淨(ametryne)、特草嗪酮(amibuzin)、胺唑草酮(amicarbazone)、拌種靈(amicarthiazol)、賽硫磷(amidithion)、磺胺蟎酯(amidoflumet)、醯嘧磺隆(amidosulfuron)、滅害威(aminocarb)、環丙嘧啶酸(aminocyclopyrachlor)、氯胺吡啶酸(aminopyralid)、胺三唑、甲基胺草磷(amiprofos-methyl)、胺草磷(amiprofos)、甲基胺草磷(amiprofos-methyl)、安美速(amisulbrom)、阿米通(amiton)、三亞蟎(amitraz)、殺草強(amitrole)、胺磺酸銨鹽、代森銨(amobam)、非晶形矽膠、非晶形二氧化矽、1-胺基丙基磷酸(ampropylfos)、AMS、毒藜鹼(anabasine)、嘧啶醇(ancymidol)、敵菌靈(anilazine)、莎稗磷(anilofos)、疏草隆(anisuron)、蒽醌(anthraquinone)、安妥(antu)、唑磷嗪(apholate)、殺蟎特(aramite)、殘殺威(arprocarb)、三氧化二砷、福美砷(asomate)、阿司匹靈(aspirin)、磺草靈(asulam)、乙基殺撲磷(athidathion)、阿特拉通(atraton)、草脫淨(atrazine)、金色制黴素(aureofungin)、、阿維菌素B1(avermectin B1)、AVG、四烯雌酮(aviglycine)、氧環唑(azaconazole)、印苦楝子素(azadirachtin)、草芬定(azafenidin)、亞滅松(azamethiphos)、滅蚜松(azidithion)、四唑嘧磺隆(azimsulfuron)、乙基谷速松(azinphosethyl)、乙基谷速松(azinphos-ethyl)、谷速松(azinphosmethyl)、谷速松(azinphos-methyl)、疊氮津(aziprotryn)、滅蘇民(aziprotryne)、塞侖(azithiram)、偶氮苯(azobenzene)、亞環錫(azocyclotin)、偶氮磷(azothoate)、亞托敏(azoxystrobin)、菊乙胺酯(bachmedesh)、燕麥靈(barban)、燕麥靈(barbanate)、六氟矽酸鋇、多硫化鋇、矽氟化鋇(barium silicofluoride)、椒菊酯(barthrin)、鹼式碳酸銅(basic copper carbonate)、鹼式氯化銅(II)(basic copper chloride)、鹼式硫酸銅(basic copper sulfate)、BCPC、氟丁醯草胺(beflubutamid)、本達樂(benalaxyl)、本達樂-M、草除靈(benazolin)、醯苯草酮(bencarbazone)、異噻蟲唑(benclothiaz)、苯噠嗪丙酯(bendaqingbingzhi)、免敵克(bendiocarb)、苯達松(bendioxide)、倍尼芬(benefin)、氟草胺(benfluralin)、免扶克(benfuracarb)、呋草黃(benfuresate)、苯嘧磺草胺(benmihuangcaoan)、麥鏽靈(benodanil)、免賴得(benomyl)、解草酮(benoxacor)、苯磷(benoxafos)、醌肟腙(benquinox)、免速隆(bensulfuron)、地散磷(bensulide)、免速達(bensultap)、苯他隆(bentaluron)、本達隆(bentazon)、本達隆(bentazone)、苯噻菌胺(benthiavalicarb)、苯噻硫氰(benthiazole)、(benthiocarb)、草噁嗪(bentranil)、苯甲醯胺氧乙酸(benzadox)、氯化烷基二甲基苄基銨、苯瑪松(benzamacril)、異噁草胺(benzamizole)、抑菌啉(benzamorf)、六氯化苯、雙苯嘧草酮(benzfendizone)、苯甲亞胺(benzimine)、苄草胺(benzipram)、苯并雙環酮(benzobicyclon)、硫丹(benzoepin)、吡草酮(benzofenap)、氟草黃(benzofluor)、苯基異羥肟酸(benzohydroxamic acid)、苯蟎特(benzomate)、苯并磷酸酯(benzophosphate)、苯并噻二唑(benzothiadiazole)、苯并烯氟菌唑(benzovindiflupyr)、西脫蟎(benzoximate)、新燕靈(benzoylprop)、苯噻隆(benzthiazuron)、苯唑草酮(benzuocaotong)、苯甲酸苄酯、苯甲基腺嘌呤(benzyladenine)、黃連素(berberine)、β-賽扶寧(beta -cyfluthrin)、β-賽滅寧(beta -cypermethrin)、比托沙(bethoxazin)、BHC、雙丙氨磷(bialaphos)、雙環哌喃酮(bicyclopyrone)、必芬蟎(bifenazate)、治草醚(bifenox)、畢芬寧(bifenthrin)、吡氟菌酯(bifujunzhi)、畢拉草(bilanafos)、百蟎克(binapacryl)、病氰硝(bingqingxiao)、百亞列寧(bioallethrin)、苄呋烯菊酯(bioethanomethrin)、生物氯菊酯(biopermethrin)、生物苄呋菊酯(bioresmethrin)、聯苯、吡殺茲(bisazir)、噻枯唑(bismerthiazol)、噻枯唑-銅(bismerthiazol-copper)、雙苯基汞亞甲基二(x-萘-y-磺酸) (bisphenylmercury methylenedi(x-naphthalene-y-sulphonate))、雙草醚(bispyribac)、雙三氟蟲脲(bistrifluron)、殺蟲雙(bisultap)、比多農(bitertanol)、硫雙二氯酚(bithionol)、聯苯吡菌胺(bixafen)、保米黴素(blasticidin-S)、硼砂、波爾多(Bordeaux)混合液、硼酸、白克列(boscalid)、BPPS、芸苔素內酯(brassinolide)、芸苔素內酯-乙基、小蠹集合信息素(brevicomin)、溴鼠隆(brodifacoum)、苄蟎醚(brofenprox)、溴滅菊酯(brofenvalerate)、溴氟苯胺(broflanilide)、溴氟菊酯(brofluthrinate)、克草(bromacil)、溴敵隆(bromadiolone)、二溴磷(bromchlophos)、溴鼠胺(bromethalin)、溴苄呋菊酯(bromethrin)、溴苯烯磷(bromfenvinfos)、溴乙醯胺(bromoacetamide)、除草溴(bromobonil)、溴丁醯草胺(bromobutide)、保滿丹(bromociclen)、保滿丹(bromocyclen)、溴-滴滴涕(DDT)、溴酚肟(bromofenoxim)、溴磷松(bromophos)、(bromomethane)、溴磷松(bromophos)、乙基-溴磷松、新殺蟎(bromopropylate)、溴菌腈(bromothalonil)、溴苯腈(bromoxynil)、殺莠敏(brompyrazon)、溴克座(bromuconazole)、溴硝醇(bronopol)、BRP、BTH、增效特(bucarpolate)、必克蝨(bufencarb)、佈敏納弗(buminafos)、布瑞莫(bupirimate)、布芬淨(buprofezin)、勃根第(Burgundy)混合液、白消安(busulfan)、白消安(busulphan)、畜蟲威(butacarb)、丁基拉草(butachlor)、布芬草(butafenacil)、牧草胺(butam)、抑草磷(butamifos)、丁烷-芬普尼(butane-fipronil)、佈伏斯(butathiofos)、丁烯草胺(butenachlor)、丁烷-芬普尼(butane-fipronil)、苄烯菊酯(butethrin)、丁硫咪唑酮(buthidazole)、丁硫啶(buthiobate)、丁噻隆(buthiuron)、脱葉磷(butifos)、佈嘉信(butocarboxim)、布托酯(butonate)、避蚊酮(butopyronoxyl)、丁酮碸威(butoxycarboxim)、比達寧(butralin)、丁苯草酮(butroxydim)、炔草隆(buturon)、丁基胺、丁酸鹽(butylate)、丁酯膦(butylchlorophos)、伸丁基-芬普尼(butylene-fipronil)、二甲胂酸(cacodylic acid)、硫線磷(cadusafos)、唑草胺(cafenstrole)、成骨醇(calciferol)、砷酸鈣、氯酸鈣、氰胺化鈣(calcium cyanamide)、氰化鈣、多硫化鈣、鈣殺畏(calvinphos)、卡本二氯(cambendichlor)、毒殺芬(camphechlor)、樟腦(camphor)、四氯丹(captafol)、蓋普丹(captan)、(carbam)、嗎菌威(carbamorph)、氯滅殺威(carbanolate)、胺甲萘(carbaril)、胺甲(carbaryl)、除草隆(carbasulam)、卡巴松(carbathion)、貝芬替(carbendazim)、多菌靈(carbendazol)、雙醯草胺(carbetamide)、卡波硫磷(carbofenotion)、加保扶(carbofuran)、二硫化碳、四氯化碳、硫化羰(carbonyl sulfide)、加芬松(carbophenothion)、馬拉硫磷(carbophos)、丁基加保扶(carbosulfan)、羧酸唑(carboxazole)、環二混劑(carboxide)、萎鏽靈(carboxin)、克繁草(carfentrazone)、加普胺(carpropamid)、培丹(cartap)、香芹酚(carvacrol)、香芹酮(carvone)、CAVP、CDAA、CDEA、CDEC、滅胞素(cellocidin)、CEPC、西拉洛(ceralure)、敵菌腙(cerenox)、沙巴達(cevadilla)、切欣特混合液(Cheshunt mixture)、愛卡士(chinalphos)、愛卡士-甲基(chinalphos-méthyl)、蟎離丹(chinomethionat)、滅蟎猛(chinomethionate)、愛卡士(chiralaxyl)、殼聚糖(chitosan)、克氯綜(chlobenthiazone)、甲氧基護谷(chlomethoxyfen)、氯醛糖(chloralose)、克爛本(chloramben)、氯胺磷(chloramine phosphorus)、氯黴素(chloramphenicol)、雙胺靈(chloraniformethan)、克氯尼(chloranil)、丁醯草胺(chloranocryl)、剋安勃(chlorantraniliprole)、炔禾靈(chlorazifop)、可樂津(chlorazine)、氯殺蟎(chlorbenside)、滅幼脲(chlorbenzuron)、冰片丹(chlorbicyclen)、滅落寧(chlorbromuron)、氯草靈(chlorbufam)、可氯丹(chlordane)、氯癸酮(chlordecone)、氯苯甲脒(chlordimeform)、氯烯炔菊酯(chlorempenthrin)、玉雄殺(chloretazate)、乙烯利(chlorethephon)、氯氧磷(chlorethoxyfos)、氯特龍(chloreturon)、伐草克(chlorfenac)、克凡派(chlorfenapyr)、2-(2-氯苯基)-1H-苯并咪唑(chlorfenazole)、殺蟎醇(chlorfenethol)、滅草隆(chlorfenidim)、燕麥酯(chlorfenprop)、殺蟎酯(chlorfenson)、敵蟎丹(chlorfensulphide)、氯芬松(chlorfenvinphos)、氯芬松-甲基(chlorfenvinphos-methyl)、克福隆(chlorfluazuron)、氟咪殺(chlorflurazole)、氯甲丹(chlorflurecol)、氯芴酸(chlorfluren)、整形醇(chlorflurenol)、氯草敏(chloridazon)、氯嘧磺隆(chlorimuron)、氯化物(chlorinate)、氯苯胺靈(chlor-IPC)、氯甲磷(chlormephos)、矮壯素陽離子(chlormequat)、磺草酮(chlormesulone)、甲氧基護谷(chlormethoxynil)、氯乙靈(chlornidine)、全滅草(chlornitrofen)、氯醋酸(chloroacetic acid)、克氯苯(chlorobenzilate)、氯二硝萘(chlorodinitronaphthalene)、殺蟎酯(chlorofénizon)、氯仿、滅蟎脒(chloromebuform)、滅蟲脲(chloromethiuron)、二氯甲氧苯(chloroneb)、氯鼠酮(chlorophacinone)、敵百蟲(chlorophos)、氯化苦(chloropicrin)、三氯丙酸(chloropon)、右旋反式氯丙炔菊酯(chloroprallethrin)、克氯蟎(chloropropylate)、四氯異苯腈(chlorothalonil)、氯麥隆(chlorotoluron)、(chloroxifenidim)、枯草隆(chloroxuron)、羥敵草腈(chloroxynil)、矮形磷(chlorphonium)、氯辛硫磷(chlorphoxim)、滅蟲吡啶(chlorprazophos)、氯普卡(chlorprocarb)、氯普芬(chlorpropham)、陶斯松(chlorpyrifos)、甲基陶斯松(chlorpyrifos-methyl)、四氯喹啉(chlorquinox)、氯磺隆(chlorsulfuron)、大克草(chlorthal)、草克樂(chlorthiamid)、克硫松(chlorthiophos)、(chlortoluron)、克氯得(chlozolinate)、乙菌利(chltosan)、膽鈣化醇(cholecalciferol)、氯化膽鹼、可芬諾(chromafenozide)、環己米特(cicloheximide)、抗倒酯(cimectacarb)、抗倒酯(cimetacarb)、瓜菊酯(cinerin)I、瓜菊酯II、瓜菊酯類(cinerins)、乙基環醯草酯(cinidon-ethyl)、環庚草醚(cinmethylin)、西速隆(cinosulfuron)、津奥啉(cintofen)、苯氰丁醯胺(ciobutide)、落草胺(cisanilide)、順式苄呋菊酯(cismethrin)、氯酰草膦(clacyfos)、環苯草酮(clefoxydim)、克崙吡林(clenpirin)、克崙吡林(clenpyrin)、剋草同(clethodim)、甘寶素(climbazole)、氯碘吡啶酯(cliodinate)、炔草酯(clodinafop)、除線威(cloethocarb)、苯噠嗪鉀(clofencet)、滴滴涕(clofenotane)、克芬蟎(clofentezine)、氯芬磷(clofenvinfos)、氯貝酸(clofibric acid)、氯丁草(clofop)、可滅蹤(clomazone)、克普草(clomeprop)、氯硝柳胺(clonitralid)、調果酸(cloprop)、環丁烯草酮(cloproxydim)、畢克草(clopyralid)、解毒喹(cloquintocet)、氯酯磺草胺(cloransulam)、氯氰碘柳胺(closantel)、可尼丁(clothianidin)、克黴唑(clotrimazole)、座果酸(cloxyfonac)、抑霉胺(cloxylacon)、抑霉胺(clozylacon)、CMA、CMMP、CMP、CMU、十二碳二烯醇(codlelure)、膽骨化醇(colecalciferol)、噻唑硫磷(colophonate)、8-羥基喹啉銅(copper 8-quinolinolate)、乙酸銅、乙醯亞砷酸銅、砷酸銅、碳酸銅、鹼式、氫氧化銅、萘酸銅、油酸銅、氯氧化銅、矽酸銅、硫酸銅、硫酸銅、鹼式、鉻酸銅鋅、氯殺鼠靈(coumachlor)、殺鼠靈(coumafène)、庫馬磷(coumafos)、克滅鼠(coumafuryl)、蠅毒磷(coumaphos)、殺鼠迷(coumatetralyl)、甲香菌酯(coumethoxystrobin)、畜蟲磷(coumithoate)、丁香菌酯(coumoxystrobin)、CPMC、CPMF、CPPC、必滅草(credazine)、甲酚(cresol)、甲苯酚(cresylic acid)、甲基鼠滅定(crimidine)、克羅米通(crotamiton)、丁烯磷(crotoxyfos)、丁烯磷(crotoxyphos)、育畜磷(crufomate)、冰晶石(cryolite)、誘蠅酮(cue-lure)、銅合浦單劑(cufraneb)、二苯隆(cumyleron)、草隆(cumyluron)、福美銅氯(cuprobam)、氧化亞銅、莪術醇(curcumenol)、CVMP、氰胺、氰草淨(cyanatryn)、氰乃淨(cyanazine)、施力松(cyanofenphos)、氰、氰乃松(cyanophos)、果蟲磷(cyanthoate)、氰蟲醯胺(cyantraniliprole)、三聚氰酸、賽座滅(cyazofamid)、賽百摧(cybutryne)、環菌胺(cyclafuramid)、環丙醯胺酸(cyclanilide)、環胺普羅(cyclaniliprole)、環戊烯菊酯(cyclethrin)、環草敵(cycloate)、環己醯亞胺(cycloheximide)、環蟎酯(cycloprate)、乙氰菊酯(cycloprothrin)、環比瑞摩(cyclopyrimorate)、環磺隆(cyclosulfamuron)、環殺草(cycloxydim)、環莠隆(cycluron)、唑蟎氰(cyenopyrafen)、賽芬胺(cyflufenamid)、賽芬蟎(cyflumetofen)、賽扶寧(cyfluthrin)、氯氟氰虫醯胺(cyhalodiamide)、賽伏草(cyhalofop)、賽洛寧(cyhalothrin)、錫蟎丹(cyhexatin)、蟎蜱胺(cymiazole)、克絕(cymoxanil)、解草胺腈(cyometrinil)、伏賜丁(cypendazole)、賽滅寧(cypermethrin)、牧草快(cyperquat)、賽芬寧(cyphenothrin)、環丙津(cyprazine)、三環噻草胺(cyprazole)、環克座(cyproconazole)、賽普洛(cyprodinil)、酯菌胺(cyprofuram)、環草胺(cypromid)、環丙磺醯胺(cyprosulfamide)、賽滅淨(cyromazine)、賽滅磷(cythioate)、賽翠斯(cytrex)、汰草龍(daimuron)、得拉本(dalapon)、丁醯肼(daminozide)、噠幼酮(dayoutong)、邁隆(dazomet)、DBCP、d -樟腦(d -camphor)、DCB、DCIP、DCPA(日本)、DCPA(美國)、DCPTA、DCU、DDD、DDPP、DDT、DDVP、咪菌威(debacarb)、癸磷錫(decafentin)、溴氰菊酯(decamethrin)、去甲基克百威(decarbofuran)、避蚊胺(deet)、去氫乙酸、敵草快(deiquat)、異丁草胺(delachlor)、大克松(delnav)、第滅寧(deltamethrin)、甲基滅賜松(demephion)、甲基滅賜松-O、甲基滅賜松-S、内吸磷(demeton)、甲基内吸磷、内吸磷-O、甲基内吸磷-O、内吸磷-S、甲基内吸磷-S、碸吸磷(demeton-S-methyl sulphon)、碸吸磷(demeton-S-methylsulphon)、DEP、生物丙烯菊酯(depalléthrine)、毒利死(derris)、甜菜安(desmedipham)、敵草淨(desmetryn)、敵草淨(desmetryne)、d -反式氯炔丙菊酯(d -fanshiluquebingjuzhi)、汰芬隆(diafenthiuron)、氯亞磷(dialifor)、得拉松(dialifos)、燕麥敵(diallate)、燕麥敵(di-allate)、除線特(diamidafos)、麥草畏(dianat)、矽藻土(diatomaceous earth)、矽藻土(diatomite)、大利松(diazinon)、二溴磷(dibrom)、酞酸二丁酯、丁二酸二丁酯、汰克草(dicamba)、異氯磷(dicapthon)、二氯苯腈(dichlobenil)、除線磷(dichlofenthion)、益發靈(dichlofluanid)、二氯萘醌(dichlone)、氯全隆(dichloralurea)、滅幼脲(dichlorbenzuron)、敵草隆(dichlorfenidim)、羧酸芴(dichlorflurecol)、二氯甲丹(dichlorflurenol)、苄胺靈(dichlormate)、二氯丙烯胺(dichlormid)、二氯甲烷、二氯酚(dichlorophen)、2,4-滴丙酸(dichlorprop)、2,4-滴丙酸-P、二氯松(dichlorvos)、賜克滅(dichlozolin)、賜克滅(dichlozoline)、苄氯三唑醇(diclobutrazol)、雙氯氰菌胺(diclocymet)、禾草靈(diclofop)、達滅淨(diclomezine)、大克爛(dicloran)、二氯滅座替(dicloromezotiaz)、雙氯磺草胺(diclosulam)、大克蟎(dicofol)、二氯二苯三氯乙烷(dicophane)、雙香豆素(dicoumarol)、大跨希(dicresyl)、雙特松(dicrotophos)、地快樂(dicryl)、雙羥香豆素(dicumarol)、環蟲腈(dicyclanil)、二環隆(dicyclonon)、地特靈(dieldrin)、得氯蟎(dienochlor)、二依馬(diethamquat)、乙醯甲草胺(diethatyl)、乙硫磷(diethion)、乙硫磷(diéthion)、乙黴威(diethofencarb)、迪艾索諾(dietholate)、(diéthon)、焦碳酸二乙酯(diethyl pyrocarbonate)、二乙甲苯醯胺(diethyltoluamide)、鼠得克(difenacoum)、待克利(difenoconazole)、戊味禾草靈(difenopenten)、枯莠隆(difenoxuron)、野燕枯(difenzoquat)、噻鼠靈(difethialone)、氟蟎(diflovidazin)、二福隆(diflubenzuron)、吡氟草胺(diflufenican)、吡氟草胺(diflufenicanil)、氟吡草腙(diflufenzopyr)、二氟林(diflumetorim)、敵草克(dikegulac)、二羥丙茶鹼(dilor)、滴馬提夫(dimatif)、四氟甲醚菊酯(dimefluthrin)、甲氟磷(dimefox)、唑隆(dimefuron)、殺蟲雙(dimehypo)、哌草丹(dimepiperate)、菌核淨(dimetachlone)、地麥威(dimetan)、混滅威(dimethacarb)、菌核淨(dimethachlone)、二甲草胺(dimethachlor)、異戊乙淨(dimethametryn)、汰草滅(dimethenamid)、汰草滅-P、噻節因(dimethipin)、二甲嘧酚(dimethirimol)、大滅松(dimethoate)、達滅芬(dimethomorph)、苄菊酯(dimethrin)、卡百酸二甲酯(dimethyl carbate)、二硫二甲烷、酞酸二甲酯、二甲基亞硝胺(dimethylvinphos)、敵蠅威(dimetilan)、草滅散(dimexano)、草噠酮(dimidazon)、醚菌胺(dimoxystrobin)、敵匹硫磷(dimpylate)、殺草隆(dimuron)、消蟎酚(dinex)、啶菌噁唑(dingjunezuo)、達克利(diniconazole)、達克利-M、撻乃安(dinitramine)、二硝基酚、大脫蟎(dinobuton)、白粉克(dinocap)、白粉克-4、白粉克-6、敵蟎消(dinocton)、地樂特(dinofenate)、硝戊酯(dinopenton)、硝丙酚(dinoprop)、戊硝酚(dinosam)、達諾殺(dinoseb)、硝辛酯殺蟎劑(dinosulfon)、達特南(dinotefuran)、特樂酚(dinoterb)、硝丁酯(dinoterbon)、苯蟲醚(diofenolan)、殺力松(dioxabenzofos)、二氧威(dioxacarb)、敵殺磷(dioxathion)、敵殺磷(dioxation)、敵鼠(diphacin)、得伐鼠(diphacinone)、得伐鼠(diphenadione)、大芬滅(diphenamid)、大芬滅(diphenamide)、二苯碸、二苯胺、硫化二苯基(diphenylsulphide)、調呋酸(diprogulic acid)、胺樂靈(dipropalin)、殺草淨(dipropetryn)、三氯松(dipterex)、大芬滅替松(dipymetitrone)、雙硫氧吡啶(dipyrithione)、大刈特(diquat)、四硼酸二鈉、殺蟲雙(disosultap)、環氧十九烷(disparlure)、麥草畏甲酯(disugran)、賽松(disul)、二硫龍(disulfiram)、二硫松(disulfoton)、普得松(ditalimfos)、腈硫醌(dithianon)、大賽伏(dithicrofos)、二硫醚、甲基乙拌磷(dithiométon)、汰硫草(dithiopyr)、達有龍(diuron)、二黄原酸(dixanthogen)、d-檸檬油精(d-limonene)、DMDS、DMPA、DNOC、十二環啉(dodemorph)、多地辛(dodicin)、多寧(dodine)、朵芬娜賓(dofenapyn)、多果定(doguadine)、多明尼卡路(dominicalure)、多滅蟲(doramectin)、DPC、肼菌酮(drazoxolon)、DSMA、右旋反式氯丙炔菊酯(d-trans-allethrin)、右旋反式苄呋菊酯(d-trans-resmethrin)、毒氟磷(dufulin)、殺草隆(dymron)、EBEP、EBP、克線丹(ebufos)、蛻皮甾酮(ecdysterone)、氯唑靈(echlomezol)、EDB、EDC、EDDP、護粒松(edifenphos)、甘草津(eglinazine)、因滅汀(emamectin)、EMPC、益避寧(empenthrin)、烯腺嘌呤(enadenine)、安殺番(endosulfan)、草多索(endothal)、草多索(endothall)、因毒磷(endothion)、安特靈(endrin)、烯肟菌酯(enestroburin)、恩康唑(enilconazole)、烯肟菌酯(enoxastrobin)、除蟎酯(ephirsulfonate)、EPN、丙醯芸苔素內酯(epocholeone)、保幼醚(epofenonane)、依普座(epoxiconazole)、乙醯胺基阿維菌素(eprinomectin)、磺唑草(epronaz)、ε-美特寧(epsilon-metofluthrin)、ε-氧苄氟菊酯(epsilon-momfluorothrin)、EPTC、抑草蓬(erbon)、鈣化醇(ergocalciferol)、二氯醯草胺(erlujixiancaoan)、富右旋反式丙烯菊酯(esdépalléthrine)、益化利(esfenvalerate)、ESP、禾草畏(esprocarb)、乙烯矽(etacelasil)、乙環唑(etaconazole)、抑他風(etaphos)、益地安(etem)、噻唑菌胺(ethaboxam)、克草胺(ethachlor)、乙丁烯氟靈(ethalfluralin)、胺苯磺隆(ethametsulfuron)、殺草胺(ethaprochlor)、乙烯利(ethephon)、磺噻隆(ethidimuron)、愛芬克(ethiofencarb)、硫草敵(ethiolate)、愛殺松(ethion)、乙嗪草酮(ethiozin)、乙蟲腈(ethiprole)、依瑞莫(ethirimol)、益硫磷(ethoate-methyl)、乙氧苯草胺(ethobenzanid)、益覆滅(ethofumesate)、乙基己二醇(ethohexadiol)、滅克磷(ethoprop)、普伏松(ethoprophos)、氯氟草醚(ethoxyfen)、乙氧基喹啉(ethoxyquin)、亞速隆(ethoxysulfuron)、吲唑酯(ethychlozate)、甲酸乙酯(ethyl formate)、焦磷酸乙酯(ethyl pyrophosphate)、乙滴涕(ethylan)、乙基-DDD、乙烯、二溴化乙烯、二氯化乙烯、環氧乙烷、乙蒜素(ethylicin)、乙基汞2,3二羥基丙基硫醇酯(ethylmercury 2,3-dihydroxypropyl mercaptide)、乙基乙酸汞(ethylmercury acetate)、乙基溴化汞(ethylmercury bromide)、乙基氯化汞、乙基磷酸汞、硝草酚(etinofen)、ETM、乙胺草醚(etnipromid)、乙氧苯草胺(etobenzanid)、依芬寧(etofenprox)、依殺蟎(etoxazole)、依得利(etridiazole)、益多松(etrimfos)、益多松(étrimphos)、丁香酚(eugenol)、EXD、凡殺同(famoxadone)、胺磺磷(famphur)、伐草克(fenac)、咪唑菌酮(fenamidone)、敵磺鈉(fenaminosulf)、烯肟菌胺(fenaminstrobin)、芬滅松(fenamiphos)、咪菌腈(fenapanil)、芬瑞莫(fenarimol)、醯苯磺威(fenasulam)、抗蟎唑(fenazaflor)、芬殺蟎(fenazaquin)、芬克座(fenbuconazole)、芬佈賜(fenbutatin oxide)、解草唑(fenchlorazole)、樂乃松(fenchlorphos)、樂乃松(fenchlorfos)、解草啶(fenclorim)、芬硫克(fenethacarb)、五氟苯菊酯(fenfluthrin)、甲呋醯胺(fenfuram)、環醯菌胺(fenhexamid)、非草隆(fenidin)、種衣酯(fenitropan)、撲滅松(fenitrothion)、芬蟎酯(fénizon)、酚菌酮(fenjuntong)、丁基滅必蝨(fenobucarb)、毒菌錫(fenolovo)、2,4,5-涕丙酸(fenoprop)、芬硫克(fenothiocarb)、芬噁寧(fenoxacrim)、芬諾尼(fenoxanil)、芬殺草(fenoxaprop)、芬殺草-P、異噁苯碸(fenoxasulfone)、芬諾克(fenoxycarb)、拌種咯(fenpiclonil)、吡氯氰菊酯(fenpirithrin)、芬普寧(fenpropathrin)、苯鏽啶(fenpropidin)、芬普福(fenpropimorph)、胺苯吡菌酮(fenpyrazamine)、芬普蟎(fenpyroximate)、芬昆諾三酮(fenquinotrione)、殺雄嗪(fenridazon)、芬蟎酯(fenson)、繁福松(fensulfothion)、氯苯氧乙醇(fenteracol)、噻唑禾草靈(fenthiaprop)、芬殺松(fenthion)、乙基芬殺松(fenthion-ethyl)、噻唑禾草靈(fentiaprop)、三苯錫(fentin)、四唑醯草胺(fentrazamide)、芳氟胺(fentrifanil)、非草隆(fenuron)、非草隆TCA、芬化利(fenvalerate)、富爾邦(ferbam)、富米綜(ferimzone)、硫酸亞鐵、芬普尼(fipronil)、麥草氟酯(flamprop)、麥草氟酯-M、伏速隆(flazasulfuron)、伏滅鼠(flocoumafen)、弗美托奎(flometoquin)、氟尼胺(flonicamid)、雙氟磺草胺(florasulam)、嘧蟎酯(fluacrypyrim)、右旋反式氯丙炔菊酯(fluazaindolizine)、伏寄普(fluazifop)、伏寄普-P (fluazifop-P)、扶吉胺(fluazinam)、異丙吡草酯(fluazolate)、氟啶蜱脲(fluazuron)、氟大滅(flubendiamide)、氟苯并胺噻唑(flubenzimine)、溴氟菊酯(flubrocythrinate)、氟酮磺隆(flucarbazone)、氟吡磺隆(flucetosulfuron)、氟消草(fluchloralin)、伏克隆(flucofuron)、氟蟎脲(flucycloxuron)、護賽寧(flucythrinate)、護汰寧(fludioxonil)、聯氟蟎(fluénéthyl)、聯苯氟(fluenetil)、氟噻蟲碸(fluensulfone)、氟噻草胺(flufenacet)、嘧蟲胺(flufenerim)、弗芬肯(flufenican)、氟芬隆(flufenoxuron)、氟菌蟎酯(flufenoxystrobin)、三氟醚菊酯(flufenprox)、氟噠草酯(flufenpyr)、氟蟎嗪(flufenzine)、丁蟲腈(flufiprole)、氟菲殺碸(fluhexafon)、氟氯苯菊酯(flumethrin)、氟醯菌胺(flumetover)、氟節胺(flumetralin)、唑嘧磺草胺(flumetsulam)、氟每淨(flumezin)、氟烯草酸(flumiclorac)、丙炔氟草胺(flumioxazin)、炔草胺(flumipropyn)、氟啉(flumorph)、可奪草(fluometuron)、氟比來(fluopicolide)、氟吡菌醯胺(fluopyram)、氟殺蟎(fluorbenside)、增糖胺(fluoridamid)、氟乙醯胺(fluoroacetamide)、氟乙酸(fluoroacetic acid)、氟咯草酮(fluorochloridone)、三氟硝草醚(fluorodifen)、乙羧氟草醚(fluoroglycofen)、氟醯亞胺(fluoroimide)、氟氯菌核利(fluoromide)、唑啶草(fluoromidine)、氟除草醚(fluoronitrofen)、氯氟吡氧乙酸(fluoroxypyr)、殺克丹(fluothiuron)、三氟苯唑(fluotrimazole)、氟嘧菌酯(fluoxastrobin)、氟胺草唑(flupoxam)、氟異丙嘧草酯(flupropacil)、氟鼠啶(flupropadine)、氟丙酸(flupropanate)、弗比南載夫隆(flupyradifurone)、氟啶嘧磺隆(flupyrsulfuron)、氟喹唑(fluquinconazole)、氟拉藍(fluralaner)、解草安(flurazole)、抑草丁(flurecol)、抑草丁(flurenol)、氟啶草酮(fluridone)、氟咯草酮(flurochloridone)、氟氯嘧定(fluromidine)、氟氯比(fluroxypyr)、呋嘧醇(flurprimidol)、硫氟磺醯胺(flursulamid)、呋草酮(flurtamone)、護矽得(flusilazole)、氟硫滅(flusulfamide)、氟蟎嗪(flutenzine)、氟噻草酯(fluthiacet)、氟噻草胺(fluthiamide)、氟停安(flutianil)、福多寧(flutolanil)、護汰芬(flutriafol)、福化利(fluvalinate)、氟唑滅特胺(fluxametamide)、氟唑菌醯胺(fluxapyroxad)、肟草安(fluxofenim)、滅菌丹(folpel)、福爾培(folpet)、氟磺胺草醚(fomesafen)、大福松(fonofos)、甲醯胺磺隆(foramsulfuron)、氟吡脲(forchlorfenuron)、甲醛、覆滅蟎(formetanate)、福木松(formothion)、藻蟎威(formparanate)、調節膦(fosamine)、福賽得(fosetyl)、丁苯硫磷(fosmethilan)、甲基氯吡磷(fospirate)、福賽絕(fosthiazate)、丁硫環磷(fosthietan)、弗羅塔林(frontalin)、四氯苯酞(fthalide)、麥穗靈(fuberidazole)、氟草淨(fucaojing)、氟草醚(fucaomi)、氟菌蟎酯(fujunmanzhi)、氟乳醚(fulumi)、薰草呋(fumarin)、氟奈西草林(funaihecaoling)、呋苯硫脲(fuphenthiourea)、乙二醇縮糠醛(furalane)、呋霜靈(furalaxyl)、炔呋菊酯(furamethrin)、福拉比(furametpyr)、呋喃蟲醯肼(furan tebufenozide)、呋線威(furathiocarb)、二甲呋醯胺(furcarbanil)、呋菌唑(furconazole)、呋菌唑(furconazole)-順式、糠醛菊酯(furethrin)、糠醛(furfural)、呋喃解草唑(furilazole)、伴種胺(furmecyclox)、呋甲硫菌靈(furophanate)、呋氧草醚(furyloxyfen)、γ-BHC、γ-賽洛寧(gamma -cyhalothrin)、γ-HCH、格蟎酯(genit)、赤黴酸(gibberellic acid)、赤黴素A3 (gibberellin A3)、赤黴素(gibberellins)、甘氟(gliftor)、鼠甘伏(glitor)、氯醛葡糖(glucochloralose)、草銨膦(glufosinate)、草銨膦-P、固毆寧(glyodin)、乙二肟(glyoxime)、嘉磷塞(glyphosate)、草甘二膦(glyphosine)、誘蟲十六酯(gossyplure)、誘殺烯混劑(grandlure)、灰黃黴素(griseofulvin)、胍諾克丁(guanoctine)、雙胍辛(guazatine)、丙烯酸喹啉酯(halacrinate)、哈洛昔芬(halauxifen)、合芬寧(halfenprox)、合芬隆(halofenozide)、鹵殺芬(halosafen)、合速隆(halosulfuron)、氟啶草(haloxydine)、合氯氟(haloxyfop)、合氯氟-P、合氯氟-R、HCA、HCB、HCH、六甲蜜胺(hemel)、海母帕(hempa)、HEOD、飛佈達(heptachlor)、烯肟菌(heptafluthrin)、飛達松(heptenophos)、增產肟(heptopargil)、除莠菌素(herbimycin)、除莠菌素A(herbimycin A)、速殺硫磷(heterophos)、六六六(hexachlor)、六六六(hexachloran)、六氯丙酮(hexachloroacetone)、六氯苯、六氯丁二烯、六氯酚(hexachlorophene)、菲克利(hexaconazole)、六伏隆(hexaflumuron)、六伏胺(hexafluoramin)、六氟鹽(hexaflurate)、紅鈴誘烯(hexalure)、己醯胺(hexamide)、菲殺淨(hexazinone)、己硫松(hexylthiofos)、合賽多(hexythiazox)、HHDN、赫洛塞呋(holosulf)、高油菜素内酯(homobrassinolide)、磺硝肟(huancaiwo)、環蟲腈(huanchongjing)、磺草靈(huangcaoling)、環菌唑(huanjunzuo)、愛美隆(hydramethylnon)、汞加芬(hydrargaphen)、熟石灰(hydrated lime)、氫氰胺(hydrogen cyanamide)、氰化氫(hydrogen cyanide)、烯蟲乙酯(hydroprene)、土菌消(hydroxyisoxazole)、殺紋寧(hymexazol)、水奎威(hyquincarb)、IAA、IBA、IBP、埃卡瑞丁(icaridin)、依滅列(imazalil)、咪草酸(imazamethabenz)、甲氧咪草煙(imazamox)、甲咪唑烟酸(imazapic)、依滅草(imazapyr)、滅草喹(imazaquin)、咪唑乙煙酸(imazethapyr)、依速隆(imazosulfuron)、易胺座(imibenconazole)、新煙鹼類(imicyafos)、益達胺(imidacloprid)、氯噻啉(imidaclothiz)、克熱淨(iminoctadine)、依普寧(imiprothrin)、依納素(inabenfide)、茚草酮(indanofan)、三嗪茚草胺(indaziflam)、因得克(indoxacarb)、枯瘟淨(inezin)、矽藻土(infusorial earth)、碘普尼(iodobonil)、碘卡佈(iodocarb)、丙胺磷(iodofenphos)、碘甲烷(iodomethane)、碘磺隆(iodosulfuron)、碘芬磺隆(iofensulfuron)、碘苯腈(ioxynil)、抑草津(ipazine)、IPC、種菌唑(ipconazole)、鹵苯胺唑(ipfencarbazone)、丙基喜樂松(iprobenfos)、依普同(iprodione)、丙森辛(iprovalicarb)、丙草定(iprymidam)、小蟲二醇烯(ipsdienol)、小蟲醇烯(ipsenol)、IPSP、IPX、依殺米朵孚斯(isamidofos)、依殺松(isazofos)、碳氯靈(isobenzan)、丁咪醯胺(isocarbamid)、丁咪醯胺(isocarbamide)、水胺硫磷(isocarbophos)、異草定(isocil)、異氯甲橋(isodrin)、亞芬松(isofenphos)、甲基亞芬松、艾索非他米(isofetamid)、異索威(isolan)、丁草酮(isomethiozin)、異草完隆(isonoruron)、異潘松(isopamphos)、氮蕈草(isopolinate)、滅必蝨(isoprocarb)、異草定(isoprocil)、異丙樂靈(isopropalin)、異丙吡草酯(isopropazol)、亞賜圃(isoprothiolane)、異丙隆(isoproturon)、萘吡菌胺(isopyrazam)、異皮莫(isopyrimol)、獲賜松(isothioate)、異噻菌胺(isotianil)、愛速隆(isouron)、異凡二酮(isovaledione)、異草胺(isoxaben)、異氯草酮(isoxachlortole)、雙苯噁唑酸(isoxadifen)、異唑草酮(isoxaflutole)、異草醚(isoxapyrifop)、加褔松(isoxathion)、異噁隆(isuron)、依維菌素(ivermectin)、異草胺(ixoxaben)、淨種磷(izopamfos)、淨種磷(izopamphos)、茉莉油(japonilure)、喃烯菊酯(japothrins)、茉酮菊酯素(jasmolin)I、茉酮菊酯素II、茉莉酸(jasmonic acid)、甲磺蒽腙(jiahuangchongzong)、甲基硝啉(jiajizengxiaolin)、甲香菊酯(jiaxiangjunzhi)、解草完(jiecaowan)、解草稀(jiecaoxi)、井崗黴素A(Jinganmycin A)、護粒松(jodfenphos)、青春激素I(juvenile hormone I)、青春激素II、青春激素III、噻嗯菊酯(kadethrin)、κ-畢芬寧(kappa -bifenthrin)、κ-汰福寧(kappa -tefluthrin)、特胺靈(karbutilate)、卡列他南(karetazan)、嘉賜黴素(kasugamycin)、柯均林(kejunlin)、氯戊環(kelevan)、酮螺氧(ketospiradox)、矽藻土(kieselguhr)、細胞分裂素(kinetin)、烯蟲炔酯(kinoprene)、精苯霜靈(kiralaxyl)、克收欣(kresoxim-methyl)、庫卡辛(kuicaoxi)、乳氟禾草靈(lactofen)、λ-賽洛寧(lambda-cyhalothrin)、拉提路(latilure)、砷酸鉛(lead arsenate)、環草定(lenacil)、里琵菌素(lepimectin)、福賜松(leptophos)、聯苯肼酯(lianbenjingzhi)、石灰硫磺(lime sulfur)、靈丹(lindane)、雷尼汀(lineatin)、理有龍(linuron)、力輪松(lirimfos)、利露(litlure)、誘池蛾酯(looplure)、祿芬隆(lufenuron)、氯氟氰虫醯胺(lüfuqingchongxianan)、氯醯草膦(lüxiancaolin)、氯啶菌酯(lvdingjunzhi)、氯氟醚菊酯(lvfumijvzhi)、氯醯草膦(lvxiancaolin)、噻唑磷(lythidathion)、M-74、M-81、MAA、磷化鎂、馬拉松(malathion)、麥迪遜(maldison)、順丁烯二醯肼(maleic hydrazide)、特蟎腈(malonoben)、麥芽糊精(maltodextrin)、MAMA、代森錳銅(mancopper)、鋅錳乃浦(mancozeb)、曼戴克敏(mandestrobin)、曼普胺(mandipropamid)、錳乃浦(maneb)、苦參鹼(matrine)、疊氮磷(mazidox)、MCC、MCP、MCPA、硫乙基MCPA、MCPB、MCPP、巴斯丹(mebenil)、滅加松(mecarbam)、苯并威(mecarbinzid)、四甲磷(mecarphon)、2-甲-4-氯丙酸(mecoprop)、2-甲-4-氯丙酸-P、殺蟎脒(medimeform)、地樂施(medinoterb)、誘殺酯(medlure)、滅芬草(mefenacet)、右滅達樂(mefenoxam)、吡唑二酸(mefenpyr)、氟磺醯草胺(mefluidide)、十四碳二烯酸(megatomoic acid)、蜜蠟醇、雙薰草素醇(melitoxin)、MEMC、美納松(menazon)、MEP、滅派林(mepanipyrim)、氯氟醚菊酯(meperfluthrin)、甲苯諾(mephenate)、美福松(mephosfolan)、甲哌啶(mepiquat)、滅普寧(mepronil)、敵蟎普(meptyldinocap)、滅蟲威(mercaptodimethur)、倍硫磷(mercaptophos)、內吸磷(mercaptophos thiol)、馬拉硫磷(mercaptothion)、氯化汞、氧化汞、氯化亞汞、脫葉亞磷(merphos)、脫葉亞磷氧化物(merphos oxide)、滅莠津(mesoprazine)、磺胺磺隆(mesosulfuron)、硝磺草酮(mesotrione)、甲硫酚(mesulfen)、倍硫磷亞碸(mesulfenfos)、每蘇芬(mesulphen)、間甲酚(metacresol)、美氟綜(metaflumizone)、滅達樂(metalaxyl)、右滅達樂(metalaxyl-M)、聚乙醛(metaldehyde)、斯美地(metam)、唑醯草胺(metamifop)、苯草酮(metamitron)、偏磷酸鈣(metaphos)、興豐寶(metaxon)、滅草胺(metazachlor)、雙醚氯吡嘧磺隆(metazosulfuron)、間氯敵菌酮(metazoxolon)、滅特座(metconazole)、甲基涕巴(metepa)、二甲噠草伏(metflurazon)、甲基苯噻隆(methabenzthiazuron)、滅克松(methacrifos)、甲基丙樂靈(methalpropalin)、威百畝(metham)、達馬松(methamidophos)、滅速克(methasulfocarb)、滅草唑(methazole)、呋菌胺(methfuroxam)、甲基苯噻隆(methibenzuron)、滅大松(methidathion)、甲硫苯威(methiobencarb)、滅賜克(methiocarb)、甲硫嘧磺隆(methiopyrisulfuron)、甲硫涕巴(methiotepa)、美西除靈(methiozolin)、滅草恆(methiuron)、殺蟲乙烯磷(methocrotophos)、速滅威(métholcarb)、醚草通(methometon)、納乃得(methomyl)、美賜平(methoprene)、蓋草津(methoprotryn)、格草淨(methoprotryne)、喹啉羧酸-丁基(methoquin-butyl)、甲醚菊酯(methothrin)、甲氧滴滴涕(methoxychlor)、滅芬諾(methoxyfenozide)、去草酮(methoxyphenone)、甲基唑磷嗪(methyl apholate)、溴甲烷、甲基丁香粉(methyl eugenol)、碘甲烷(methyl iodide)、異硫氰酸甲酯(methyl isothiocyanate)、甲基巴拉松(methyl parathion)、甲基乙酯磷(methylacetophos)、甲氯仿、甲基二硫胺甲酸(methyldithiocarbamic acid)、甲基殺草隆(methyldymron)、二氯甲烷、甲基亞芬松(methyl-isofenphos)、甲基倍硫磷(methylmercaptophos)、甲基倍硫磷氧化物(methylmercaptophos oxide)、甲基內吸磷(methylmercaptophos thiol)、甲基苯甲酸汞(methylmercury benzoate)、甲基汞二氰二胺(methylmercury dicyandiamide)、甲基五氯苯氧化汞(methylmercury pentachlorophenoxide)、亞甲癸醯胺(methylneodecanamide)、殺螟硫磷(methylnitrophos)、保棉磷(methyltriazothion)、唑嘧磺草胺(metiozolin)、免得爛(metiram)、免得爛鋅(metiram-zinc)、吡喃隆(metobenzuron)、撲奪草(metobromuron)、美特寧(metofluthrin)、莫多草(metolachlor)、治滅蝨(metolcarb)、苯磺隆(metometuron)、苯氧菌胺(metominostrobin)、磺草唑胺(metosulam)、蟲酮(metoxadiazone)、甲氧隆(metoxuron)、滅芬農(metrafenone)、代森聯(metriam)、滅必淨(metribuzin)、敵百蟲(metrifonate)、敵百蟲(metriphonate)、噻菌胺(metsulfovax)、磺隆(metsulfuron)、美文松(mevinphos)、治克威(mexacarbate)、滅除威(miechuwei)、邁森(mieshuan)、滅蚊菊酯(miewenjuzhi)、密滅汀(milbemectin)、倍脈心(milbemycin oxime)、代森環(milneb)、嘧蟎胺(mimanan)、丙胺氟磷(mipafox)、MIPC、滅蟻樂(mirex)、MNAF、蘑菇醇(moguchun)、稻得壯(molinate)、殺蟲單(molosultap)、氧苄氟菊酯(momfluorothrin)、庚醯草胺(monalide)、莫尼速隆(monisuron)、單甲脒(monoamitraz)、一氯乙酸、亞素靈(monocrotophos)、綠谷龍(monolinuron)、殺蟲單(monomehypo)、舒非侖(monosulfiram)、單嘧磺隆(monosulfuron)、殺蟲單(monosultap)、滅草隆(monuron)、滅草隆TCA、伐草快(morfamquat)、嗎啉胍(moroxydine)、茂硫磷(morphothion)、墨茲(morzid)、莫西菌素(moxidectin)、MPMC、MSMA、MTMC、誘蟲烯(muscalure)、邁克尼(myclobutanil)、滅克寧(myclozolin)、三十醇(myricyl alcohol)、N-(乙基汞)-對-甲苯磺醯胺苯、NAA、NAAm、代森鈉(nabam)、萘肽磷(naftalofos)、乃力松(naled)、萘、萘乙醯胺、萘二甲酸酐(naphthalic anhydride)、萘酞磷(naphthalophos)、萘氧乙酸、萘乙酸、萘啉烷-1,3- 二酮(naphthylindane-1,3-diones)、萘氧基乙酸(naphthyloxyacetic acids)、萘丙胺(naproanilide)、滅落脫(napropamide)、滅落脫-M(napropamide-M)、納得爛(naptalam)、納他黴素(natamycin)、NBPOS、草不隆(neburea)、草不龍(neburon)、安特靈(nendrin)、新菸鹼、尼克羅福(nichlorfos)、除草醚(niclofen)、氯硝柳胺(niclosamide)、啶醯菌胺(nicobifen)、煙嘧磺隆(nicosulfuron)、尼古丁、硫酸菸鹼(nicotine sulfate)、伏蟻靈(nifluridide)、尼克黴素(nikkomycins)、NIP、吡氯草胺(nipyraclofen)、氟氯草胺(nipyralofen)、烯啶蟲胺(nitenpyram)、硝乙脲噻唑(nithiazine)、滅殺草(nitralin)、氯啶(nitrapyrin)、戊氰威(nitrilacarb)、護谷(nitrofen)、三氟甲草醚(nitrofluorfen)、硝苯乙烯(nitrostyrene)、酞菌酯(nitrothal-isopropyl)、鼠特靈(nobormide)、壬醇、鼠特靈(norbormide)、草完隆(norea)、氟草敏(norflurazon)、降菸鹼(nornicotine)、草完隆(noruron)、諾伐隆(novaluron)、多氟脲(noviflumuron)、NPA、尼瑞莫(nuarimol)、諾瑞隆(nuranone)、OCH、八氯二丙基醚、辛噻酮(octhilinone)、鄰二氯苯(o-dichlorobenzene)、呋醯胺(ofurace)、歐滅松(omethoate)、鄰苯基苯酚、坪草丹(orbencarb)、歐弗拉洛(orfralure)、坪草丹(orthobencarb)、鄰二氯苯(ortho-dichlorobenzene)、嘧苯胺磺隆(orthosulfamuron)、歐塔路(oryctalure)、肟醚菌胺(orysastrobin)、歐拉靈(oryzalin)、王草腦(osthol)、王草腦(osthole)、歐斯措莫(ostramone)、除蟎酯(ovatron)、蟎淨(ovex)、解草腈(oxabetrinil)、丙炔草酮(oxadiargyl)、樂滅草(oxadiazon)、毆殺斯(oxadixyl)、草氨酸酯(oxamate)、歐殺滅(oxamyl)、草噠松(oxapyrazon)、草噠松(oxapyrazone)、環氧嘧磺隆(oxasulfuron)、奧賽普林(oxathiapiprolin)、 草酮(oxaziclomefone)、快得寧(oxine-copper)、快得寧(oxine-Cu)、歐索林酸(oxolinic acid)、咪唑(oxpoconazole)、嘉保信(oxycarboxin)、滅多松(oxydemeton-methyl)、異亞碸磷(oxydeprofos)、碸拌磷(oxydisulfoton)、羥烯腺嘌呤(oxyenadenine)、復祿芬(oxyfluorfen)、氧化苦參鹼(oxymatrine)、土黴素(oxytetracycline)、滅蟎猛(oxythioquinox)、PAC、巴克素(paclobutrazol)、哌蟲啶(paichongding)、亞烈寧(palléthrine)、PAP、對-二氯苯(para-dichlorobenzene)、對氟隆(parafluron)、巴拉刈(paraquat)、巴拉松(parathion)、甲基巴拉松、苯吡醇(parinol)、巴黎綠(Paris green)、PCNB、PCP、PCP-Na、對-二氯苯(p-dichlorobenzene)、PDJ、克草猛(pebulate)、消蟎酚(pédinex)、披扶座(pefurazoate)、壬酸(pelargonic acid)、平克座(penconazole)、賓克隆(pencycuron)、施得圃(pendimethalin)、半滴乙酯(penfenate)、戊苯吡菌胺(penflufen)、氟幼脲(penfluron)、二甲戊靈(penoxalin)、平速爛(penoxsulam)、五氯酚(pentachlorophenol)、月桂酸五氯苯酯(pentachlorophenyl laurat)、甲氯醯草胺(pentanochlor)、噻菌胺(penthiopyrad)、百滅寧(pentmethrin)、環戊草酮(pentoxazone)、滅蟻靈(perchlordecone)、苯氟磺安(perfluidone)、百滅寧(permethrin)、烯草胺(pethoxamid)、PHC、氰烯菌胺(phenamacril)、乙基氰烯菌胺(phenamacril-ethyl)、敵磺鈉(phénaminosulf)、葉枯淨(phenazine oxide)、酚那卡貝(phénétacarbe)、棉胺寧(phenisopham)、芬硫磷(phenkapton)、甜菜寧(phenmedipham)、乙基甜菜寧、醯草隆(phenobenzuron)、酚硫殺(phenothiol)、酚丁滅寧(phenothrin)、苯蟎醚(phenproxide)、賽達松(phenthoate)、苯基汞脲(phenylmercuriurea)、苯基乙酸汞(phenylmercury acetate)、苯基汞氯化物(phenylmercury chloride)、焦兒茶酚之苯基汞衍生物(phenylmercury derivative of pyrocatechol)、硝酸苯汞(phenylmercury nitrate)、苯基汞水楊酸鹽(phenylmercury salicylate)、福瑞松(phorate)、毒鼠磷(phosacetim)、裕必松(phosalone)、特丁淨(phosametine)、毒鼠磷(phosazetim)、毒鼠磷(phosazetin)、三磷錫(phoscyclotin)、氯瘟磷(phosdiphen)、乙磷(phosethyl)、硫環磷(phosfolan)、硫環磷-甲基(phosfolan-methyl)、甘胺硫磷(phosglycin)、益滅松(phosmet)、對氯硫磷(phosnichlor)、磷醯胺(phosphamide)、福賜米松(phosphamidon)、膦、草丁膦(phosphinothricin)、磷克(phosphocarb)、磷、三磷錫(phostin)、巴賽松(phoxim)、甲基巴賽松、熱必斯(phthalide)、亞胺硫磷(phthalophos)、胺菊酯(phthalthrin)、皮卡布西(picarbutrazox)、避卡蚋叮(picaridin)、畢克爛(picloram)、氟吡醯草胺(picolinafen)、啶氧菌酯(picoxystrobin)、鏈黴菌素(pimaricin)、殺鼠酮(pindone)、唑啉草酯(pinoxaden)、哌丙靈(piperalin)、哌(piperazine)、胡椒基丁氧化物、胡椒基環己烯酮(piperonyl cyclonene)、哌草磷(piperophos)、哌壯素(piproctanly)、哌壯素(piproctanyl)、增效醛(piprotal)、必美松(pirimetaphos)、比加普(pirimicarb)、滅鼠優(piriminil)、嘧啶氧磷(pirimioxyphos)、必滅松(pirimiphos-ethyl)、亞特松(pirimiphos-methyl)、殺鼠酮(pival)、殺鼠酮(pivaldione)、三氯殺三氯酯(plifenate)、PMA、PMP、聚丁烯(polybutenes)、聚胺甲酸酯(polycarbamate)、多氯化莰烯(polychlorcamphene)、聚乙氧基喹啉(polyethoxyquinoline)、保粒黴素D (polyoxin D)、保粒黴素(polyoxins)、保粒黴素丁(polyoxorim)、多噻烷(polythialan)、亞砷酸鉀(potassium arsenite)、疊氮化鉀(potassium azide)、氰酸鉀、乙基黃原酸鉀(potassium ethylxanthate)、環烷酸鉀(potassium naphthenate)、多硫化鉀(potassium polysulfide)、硫氰酸鉀(potassium thiocyanate)、4,4-滴滴涕(pp’ -DDT)、普亞烈寧(prallethrin)、早熟素I(precocene I)、早熟素II、早熟素III、普拉草(pretilachlor)、嘧啶松(primidophos)、氟嘧磺隆(primisulfuron)、撲殺熱(probenazole)、撲克拉(prochloraz)、丙氯醇(proclonol)、丙腈津(procyazine)、撲滅寧(procymidone)、氨氟樂靈(prodiamine)、佈飛松(profenofos)、氟唑草胺(profluazol)、環丙氟靈(profluralin)、丙氟菊酯(profluthrin)、氯苯噻草酮(profoxydim)、(profurite-aminium)、丙草止津(proglinazine)、調環酸(prohexadione)、茉莉酮(prohydrojasmon)、蜱虱威(promacyl)、普滅克(promecarb)、撲滅通(prometon)、佈滅淨(prometryn)、佈滅淨(prometryne)、捕滅鼠(promurit)、拿草特(pronamide)、雷蒙得(propachlor)、丙蟲磷(propafos)、普羅帕脒(propamidine)、普拔克(propamocarb)、除草寧(propanil)、加護松(propaphos)、普拔草(propaquizafop)、毆蟎多(propargite)、撲蟲菊(proparthrin)、普拔根(propazine)、撲達松(propetamphos)、苯胺靈(propham)、普克利(propiconazole)、羥哌酯(propidine)、甲基鋅乃浦(propineb)、異丙草胺(propisochlor)、安丹(propoxur)、丙苯磺隆(propoxycarbazone)、丙基增效劑(propyl isome)、咪唑嘧磺隆(propyrisulfuron)、戊炔草胺(propyzamide)、丙氧喹啉(proquinazid)、骨酯素(prosuler)、甲硫磺樂靈(prosulfalin)、苄草丹(prosulfocarb)、三氟丙磺隆(prosulfuron)、乙噻唑磷(prothidathion)、胺丙威(prothiocarb)、丙硫菌唑(prothioconazole)、普硫松(prothiofos)、飛克松(prothoate)、丙苯烴菊酯(protrifenbute)、撲滅生(proxan)、吡嘧丹磷(prymidophos)、丙炔草胺(prynachlor)、補骨脂素(psoralen)、補骨脂素(psoralene)、吡達農(pydanon)、氟唑菌醯羥胺(pydiflumetofen)、派福布敏(pyflubumide)、派滅淨(pymetrozine)、賜加落(pyracarbolid)、白克松(pyraclofos)、雙唑草腈(pyraclonil)、百克敏(pyraclostrobin)、派芬草(pyraflufen)、必伏清(pyrafluprole)、嘧啶威(pyramat)、唑胺菌酯(pyrametostrobin)、唑菌酯(pyraoxystrobin)、磺醯草吡唑(pyrasulfotole)、必記福敏(pyraziflumid)、(pyrazolate)、苄草唑(pyrazolynate)、殺草敏(pyrazon)、白粉松(pyrazophos)、百速隆(pyrazosulfuron)、彼硫磷(pyrazothion)、普芬草(pyrazoxyfen)、吡菊酯(pyresmethrin)、除蟲菊精I、除蟲菊精II、除蟲菊精類、草醚-異丙基(pyribambenz-isopropyl)、草醚-丙基(pyribambenz-propyl)、吡菌苯威(pyribencarb)、嘧啶肟草醚(pyribenzoxim)、稗草丹(pyributicarb)、氯草定(pyriclor)、畢達本(pyridaben)、噠草福(pyridafol)、啶蟲丙醚(pyridalyl)、必芬松(pyridaphenthion)、噠嗪硫磷(pyridaphenthione)、必汰草(pyridate)、雙滴保(pyridinitril)、比芬諾(pyrifenox)、氟蟲吡喹(pyrifluquinazon)、環酯草醚(pyriftalid)、吡嘧他磷(pyrimétaphos)、派美尼(pyrimethanil)、抗蚜威(pyrimicarbe)、畢汰芬(pyrimidifen)、嘧草醚(pyriminobac)、嘧蟎胺(pyriminostrobin)、乙基嘧啶磷(pyrimiphos-éthyl)、甲基嘧啶磷(pyrimiphos-méthyl)、吡嘧蘇芬(pyrimisulfan)、嘧硫磷(pyrimitate)、滅鼠優(pyrinuron)、甲氧苯啶菌(pyriofenone)、必清(pyriprole)、吡啶醇(pyripropanol)、百利普芬(pyriproxyfen)、啶菌噁唑(pyrisoxazole)、嘧硫草醚(pyrithiobac)、吡唑威(pyrolan)、百快隆(pyroquilon)、吡唑碸(pyroxasulfone)、甲氧磺草胺(pyroxsulam)、氯甲氧吡啶(pyroxychlor)、氯吡根呋醚(pyroxyfur)、嗪草酸(qincaosuan)、青枯靈(qingkuling)、苦木(quassia)、喹烯酮(quinacetol)、拜裕松(quinalphos)、甲基拜裕松、醌菌腙(quinazamid)、快克草(quinclorac)、喹克座(quinconazole)、氯甲喹啉酸(quinmerac)、滅藻醌(quinoclamine)、滅蟎猛(quinomethionate)、氯藻胺(quinonamid)、畜寧磷(quinothion)、快諾芬(quinoxyfen)、喹硫磷(quintiofos)、五氯硝苯(quintozene)、快伏草(quizalofop)、快伏草-P、驅蚊酯(quwenzhi)、驅蠅啶(quyingding)、吡咪唑(rabenzazole)、碘醚柳胺(rafoxanide)、(R-diniconazole)、二乙基苯甲醯胺(rebemide)、敵草快(reglone)、瑞毒隆(renriduron)、列卡路(rescalure)、列滅寧(resmethrin)、硫氰苯胺(rhodethanil)、鬧羊花毒素-III(rhodojaponin-III)、病毒唑(ribavirin)、碸嘧磺隆(rimsulfuron)、丁蟲腈(rizazole)、R-滅達樂(R-metalaxyl)、硫氰苯胺(rodéthanil)、皮蠅磷(ronnel)、魚藤酮(rotenone)、蘭尼汀(ryania)、沙巴藜蘆(sabadilla)、嘧啶肟草醚(saflufenacil)、噻菌茂(saijunmao)、噻森銅(saisentong)、柳醯胺苯、氟矽菊酯(salifluofen)、血根鹼(sanguinarine)、山道年(santonin)、右亞列寧(S-bioallethrin)、八甲焦磷醯胺(schradan)、海蔥糖苷(scilliroside)、另丁津(sebuthylazine)、仲丁通(secbumeton)、環丙吡菌胺(sedaxane)、色拉菌素(selamectin)、單甲咪(semiamitraz)、增效菊(sesamex)、芝麻啉(sesamolin)、西松(sesone)、西殺草(sethoxydim)、西維因(sevin)、雙甲胺草磷(shuangjiaancaolin)、雙甲胺草磷(shuangjianancaolin)、S-烯蟲乙酯(S-hydroprene)、環草隆(siduron)、西福明津治(sifumijvzhi)、誘蟲環(siglure)、矽護芬(silafluofen)、雜氮矽三環(silatrane)、矽氣凝膠(silica aerogel)、矽膠、矽噻菌胺(silthiofam)、矽噻菌胺(silthiopham)、矽噻菌胺(silthiophan)、2,4,5-涕丙酸(silvex)、草滅淨(simazine)、矽氟唑(simeconazole)、西瑪通(simeton)、西草淨(simetryn)、西草淨(simetryne)、殺雄啉(sintofen)、S-烯蟲炔酯(S-kinoprene)、熟石灰(slaked lime)、SMA、S-美賜平(S-methoprene)、左旋莫多草(S-metolachlor)、亞砷酸鈉、疊氮化鈉、氯酸鈉、氰化鈉、氟化鈉、氟乙酸鈉、六氟矽酸鈉、環烷酸鈉(sodium naphthenate)、鄰苯基苯酚化鈉(sodium o-phenylphenoxide)、鄰苯基苯酚化鈉(sodium orthophenylphenoxide)、五氯酚鈉(sodium pentachlorophenate)、五氯酚鈉(sodium pentachlorophenoxide)、多硫化鈉(sodium polysulfide)、氟矽酸鈉(sodium silicofluoride)、四硫代硫酸鈉(sodium tetrathiocarbonate)、硫氰酸鈉、斯隆(solan)、蘇硫磷(sophamide)、賜諾特(spinetoram)、賜諾殺(spinosad)、賜派芬(spirodiclofen)、螺甲蟎酯(spiromesifen)、螺蟲乙酯(spirotetramat)、螺環菌胺(spiroxamine)、司替羅磷(stirofos)、鏈黴素(streptomycin)、番木鼈鹼(strychnine)、食菌甲誘醇(sulcatol)、殺克隆(sulcofuron)、磺草酮(sulcotrione)、草克死(sulfallate)、氟磺唑草胺(sulfentrazone)、舒非侖(sulfiram)、氟蟲胺(sulfluramid)、磺噻隆(sulfodiazole)、嘧磺隆(sulfometuron)、草硫磷(sulfosate)、磺醯磺隆(sulfosulfuron)、治螟磷(sulfotep)、治螟磷(sulfotepp)、氟啶蟲胺腈(sulfoxaflor)、亞碸(sulfoxide)、硫肟磷(sulfoxime)、硫、硫酸、磺醯氟、蘇葡卡賓(sulglycapin)、草硫磷(sulphosate)、硫丙磷(sulprofos)、戊苯碸(sultropen)、滅草靈(swep)、τ-福化利(tau -fluvalinate)、稗草烯(tavron)、噻蟎威(tazimcarb)、TBTO、TBZ、TCA、TCBA、TCMTB、TCNB、TDE、得克利(tebuconazole)、得芬諾(tebufenozide)、得芬瑞(tebufenpyrad)、異丁乙氧喹啉(tebufloquin)、丁基嘧啶磷(tebupirimfos)、牧草胺(tebutam)、得匍隆(tebuthiuron)、克枯爛(tecloftalam)、四氯硝基苯(tecnazene)、福美雙聯(tecoram)、三氯殺蟎碸(tedion)、得福隆(teflubenzuron)、汰福寧(tefluthrin)、特呋三酮(tefuryltrione)、環磺酮(tembotrione)、替美磷(temefos)、亞培松(temephos)、替哌(tepa)、TEPP、得殺草(tepraloxydim)、吡喃草酮(teproloxydim)、環戊烯丙菊酯(terallethrin)、特草定(terbacil)、特草靈(terbucarb)、特丁草胺(terbuchlor)、托福松(terbufos)、特丁通(terbumeton)、特丁津(terbuthylazine)、芽根靈(terbutol)、特丁淨(terbutryn)、特丁淨(terbutryne)、五氯硝基苯(terraclor)、土黴素(terramicin)、土黴素(terramycin)、四環唑(tetcyclacis)、四氯乙烷(tetrachloroethane)、樂本松(tetrachlorvinphos)、四克利(tetraconazole)、得脫蟎(tetradifon)、殺蟎好(tetradisul)、四氟隆(tetrafluron)、治滅寧(tetramethrin)、四氟醚菊酯(tetramethylfluthrin)、四胺、殺蟎黴素(tetranactin)、四普羅(tetraniliprole)、四氟丙酸鈉(tetrapion)、殺蟎硫醚(tetrasul)、硫酸鉈(thallium sulfate)、硫酸鉈(thallous sulfate)、欣克草(thenylchlor)、θ-賽滅寧(cypermethrin)、腐絕(thiabendazole)、賽果培(thiacloprid)、噻二(thiadiazine)、噻噠氟(thiadifluor)、賽速安(thiamethoxam)、噻磺隆(thiameturon)、蟲腈(thiapronil)、噻氟隆(thiazafluron)、噻氟隆(thiazfluron)、噻唑(thiazone)、噻草啶(thiazopyr)、賽伏(thicrofos)、噻菌腈(thicyofen)、噻二唑草胺(thidiazimin)、噻苯隆(thidiazuron)、酮脲磺草吩酯(thiencarbazone)、噻吩磺隆(thifensulfuron)、賽氟滅(thifluzamide)、乙汞硫柳酸鈉(thimerosal)、甲拌磷(thimet)、殺丹(thiobencarb)、抗蟲威(thiocarboxime)、硫氯苯亞胺(thiochlorfenphim)、硫氯苯亞胺(thiochlorphenphime)、氰硫二硝基苯(thiocyanatodinitrobenzenes)、硫賜安(thiocyclam)、硫丹(thiodan)、噻菌-銅(thiodiazole-copper)、硫敵克(thiodicarb)、久效威(thiofanocarb)、硫伐隆(thiofanox)、硫氟肟(thiofluoximate)、不育硫磷(thiohempa)、硫柳汞(thiomersal)、硫滅松(thiometon)、治線磷(thionazin)、多保淨(thiophanate)、乙基多保淨(thiophanate-ethyl)、甲基多保淨(thiophanate-methyl)、對硫磷(thiophos)、克殺蟎(thioquinox)、胺基硫脲(thiosemicarbazide)、殺蟲雙(thiosultap)、噻替派(thiotepa)、殺線威(thioxamyl)、得恩地(thiram)、秋蘭姆(thiuram)、蘇力菌素(thuringiensin)、噻苯達唑(tiabendazole)、噻醯菌胺(tiadinil)、氟丙嘧草酯(tiafenacil)、調劑胺(tiaojiean)、TIBA、噻蟎胺(tifatol)、仲草丹(tiocarbazil)、啼草胺(tioclorim)、替奧沙芬(tioxazafen)、替係米(tioxymid)、威線肟(tirpate)、TMTD、脫克松(tolclofos-methyl)、脫芬瑞(tolfenpyrad)、托普洛卡(tolprocarb)、托普瑞蕾特(tolpyralate)、對甲抑菌靈(tolyfluanid)、甲基益發靈(tolylfluanid)、甲苯基乙酸汞、托馬蘭(tomarin)、吡草磺(topramezone)、德克沙芬(toxaphene)、TPN、三甲苯草酮(tralkoxydim)、溴氯氰菊酯(tralocythrin)、泰滅寧(tralomethrin)、曲洛比利(tralopyril)、拜富寧(transfluthrin)、反式百滅寧(transpermethrin)、曲他胺(tretamine)、三十烷醇(triacontanol)、三泰芬(triadimefon)、三泰隆(triadimenol)、氟酮磺草胺(triafamone)、野麥畏(triallate)、野麥畏(tri-allate)、三唑磷胺(triamiphos)、抑芽唑(triapenthenol)、三苯噻蟎吩(triarathene)、嘧菌醇(triarimol)、醚苯磺隆(triasulfuron)、唑蚜威(triazamate)、丁三唑(triazbutil)、三氟草胺(triaziflam)、三落松(triazophos)、乙基谷硫磷(triazothion)、唑菌(triazoxide)、鹼式氯化銅(tribasic copper chloride)、三元硫酸銅(tribasic copper sulfate)、苯磺隆(tribenuron)、脫葉磷(tribufos)、氧化三丁基錫、殺草畏(tricamba)、水楊菌胺(trichlamide)、三氯吡氧乙酸(trichlopyr)、三氯松(trichlorfon)、樂乃松(trichlormetaphos)-3、毒壤膦(trichloronat)、壤蟲磷(trichloronate)、三氯三硝基苯(trichlorotrinitrobenzenes)、敵百蟲(trichlorphon)、三氯比(triclopyr)、三環吡菌威(triclopyricarb)、三甲酚(tricresol)、三賽唑(tricyclazole)、三環己基氫氧化錫(tricyclohexyltin hydroxide)、三得芬(tridemorph)、滅草環(tridiphane)、草達津(trietazine)、蝸螺殺(trifenmorph)、三氯丙氧磷(trifenofos)、三氟敏(trifloxystrobin)、三氟啶磺隆(trifloxysulfuron)、三福戴嗎沙(trifludimoxazin)、三福滅作派林(triflumezopyrim)、賽福座(triflumizole)、三福隆(triflumuron)、三福林(trifluralin)、氟胺磺隆(triflusulfuron)、三氟苯氧丙酸(trifop)、三氟禾草肟(trifopsime)、賽福寧(triforine)、三羥基三、誘蠅羧酯(trimedlure)、混滅威(trimethacarb)、三甲隆(trimeturon)、抗倒酯(trinexapac)、三苯錫(triphenyltin)、烯蟲硫酯(triprene)、三丙丹(tripropindan)、雷公藤甲素(triptolide)、草達克(tritac)、殺蟲釘(trithialan)、滅菌唑(triticonazole)、三氟甲磺隆(tritosulfuron)、特朗扣(trunc-call)、脱葉磷(tuoyelin)、單克素(uniconazole)、單克素(uniconazole)-P、福美甲胂(urbacide)、烏瑞替派(uredepa)、戊酸酯(valerate)、維利黴素(validamycin)、維利黴素A(validamycin A)、伐利芬奈蕾特(valifenalate)、異殺鼠酮(valone)、繁米松(vamidothion)、泛佳(vangard)、凡力(vaniliprole)、萬隆(vernolate)、免克寧(vinclozolin)、維生素D3 (vitamin D3)、華法林(warfarin)、硝蟲硫磷(xiaochongliulin)、辛菌胺(xinjunan)、烯肟菌胺(xiwojunan)、烯肟菌酯(xiwojunzhi)、XMC、二甲苯草胺(xylachlor)、二甲苯酚(xylenols)、滅爾蝨(xylylcarb)、噻蟎胺(xymiazole)、依希淨(yishijing)、氰菌胺(zarilamid)、玉米素(zeatin)、增效胺(zengxiaoan)、增效林(zengxiaolin)、ζ-賽滅寧(zeta-cypermethrin)、萘酸鋅、磷化鋅(zinc phosphide)、噻唑鋅(zinc thiazole)、噻唑鋅(zinc thiozole)、三氯酚鋅(zinc trichlorophenate)、三氯酚鋅(zinc trichlorophenoxide)、鋅乃浦(zineb)、福美鋅(ziram)、左拉伏(zolaprofos)、華法林鈉(zoocoumarin)、座賽胺(zoxamide)、唑胺菌酯(zuoanjunzhi)、唑草胺(zuocaoan)、唑菌酯(zuojunzhi)、唑嘧磺隆(zuomihuanglong)、α-氯醇(α-chlorohydrin)、α-蛻皮激素(α-ecdysone)、α-多紋素(α-multistriatin)、α-萘乙酸(α-naphthaleneacetic acid)，及β-蛻皮激素(β-ecdysone)；(2) 下列分子(a) N-(3-氯-1-(吡啶-3-基)-1H-吡唑-4-基)-N-乙基-3-((3,3,3-三 氟丙基)硫)丙醯胺(此後稱為“AI–1 ”) (b) (3S,6S,7R,8R)-8-苯甲基-3-(3-((異丁醯氧基)甲氧基)-4-甲氧基吡啶甲醯胺基)-6-甲基-4,9-二氧-1,5-二氧雜環壬-7-基 異丁酸酯((3S,6S,7R,8R)–8–benzyl–3–(3–((isobutyryloxy)methoxy)–4–methoxypicolinamido)–6–methyl–4,9–dioxo–1,5–dioxonan–7–yl isobutyrate) (此後稱為“AI–2 ”) (3) 一種被稱為羅提蘭(Lotilaner)的分子，其具有下列結構；以及(4) 表A中的下列分子表A- M#- 活性成分 的結構 The term "active ingredient cluster group α" (hereinafter referred to as "AIGA") "collectively means based the following materials: (1) (3-ethoxypropyl) mercury bromide, 1,2-dibromoethane, 1 ,2-dichloroethane, 1,2-dichloropropane, 1,3-dichloropropene, 1-MCP, 1-methylcyclopropene, 1-naphthol, 2-(octylthio)ethanol, 2,3,3-TPA, 2,3,5-triiodobenzoic acid, 2,3,6-TBA, 2,4,5-T, 2,4,5-TB, 2,4,5-TP , 2,4-D, 2,4-DB, 2,4-DEB, 2,4-DEP, 2,4-DES, 2,4-DP, 2,4-MCPA, 2,4-MCPB, 2iP , 2-methoxyethyl mercury chloride, 2-phenylphenol, 3,4-DA, 3,4-DB, 3,4-DP, 3,6-dichloro 2-picolinic acid, 4-amine Pyridine, 4-CPA, 4-CPB, 4-CPP, 4-hydroxyphenethyl alcohol, 8-hydroxyquinoline sulfate, 8-phenylmercaptoquinoline, abamectin, A Abamectin-aminomethyl, abscisic acid, ACC, acephate, acequinocyl, acetamiprid, acethion, B Acetochlor, acetofenate, acetophos, acetoprole, acibenzolar, acifluorf En), alexifen, CAN, acrep, acrinthrin, acrolein, acrylonitrile, acypetacs, Afidol Afidopyropen, afoxolaner, alachlor, alanap, alanycarb, albendazole, aldicarb, dexamethasone , aldimorph, aldoxycarb, aldrin, allethrin, allicin, allidochlor, alosamide ), alloxydim, allyl alcohol, allyxycarb, arolac, alpha- cypermethrin, alpha- endosulfan, sub Alphamethrin, altretamine, aluminum phosphide, aluminum phosphide, ametoctradin, ametridione, ametryn ), ametryne, amiguzin, amicarbazone, amikathiazol, amidithion, sulfamethoxazole Flumet), amidosulfuron, aminocarb, aminocyclopyrachlor, aminopyralid, amine triazole, amiprofos-methyl, amine Amiprofos, amiprofos-methyl, amisulbrom, amiton, amitraz, amitrol, ammonium sulfonate, Amobam, amorphous silicone, amorphous cerium oxide, 1-aminopropyl phosphate (ampropylfos), AMS, anabasine, ancymidol, anilazine, sa Anilofos, anisuron, anthraquinone, antu, apholate, aramite, arprocarb, arsenic trioxide, arsenic (asomate) ), aspirin, asulam, athidathion, attraton, atrazine, aureofungin, Avermectin B1, AVG, avidycine, azaconazole, azadirachtin, azafen Idin), azamethiphos, azidithion, azimsulfuron, azinphosethyl, azinphos-ethyl, tamarind Azinphosmethyl), azinphos-methyl, aziprotryn, aziprotryne, azithiram, azobenzene, azocyclotin, azophos Azothoate), azoxystrobin, bachmedesh, barban, barbanate, barium hexafluoroantimonate, barium polysulfide, barium silicofluoride, pepper Barthrin, basic copper carbonate, basic copper chloride, basic copper sulfate, BCPC, beflubutamid , benalaxyl, bendal-M, benazolin, bencarbazone, benclothiaz, benazine, and beneficiary Bendiocarb), bendioxide, benefin, benfluralin, benfuracarb, benfures Ate), bensulfuron (benmihuangcaoan), bendanil, benomyl, benoxacor, benzene Benzofos, benquinox, bensulfuron, bensulide, bensultap, bentaluron, bentazon, bindarone Bentazone), benthiavalicarb, benthiazole, benthiocarb, bentranil, benzodox, alkyl dimethyl benzyl ammonium chloride , benzamril (benzamacril), benzalizole, benzamorf, hexachlorobenzene, benzfendizone, benzimimine, benzalkonium (benzipram) ), benzobicyclon, benzoepin, benzofenap, benzofluor, benzohydroxamic acid, benzomate, benzo Benzophosphate, benzothiadiazole, benzovindiflupyr, benzoximate, benzoylprop, benzthiazuron, oxafluridone (benzuocaotong), benzyl benzoate, benzyladenine, berberine, beta-cynin ( beta- c) Yfluthrin), beta- cypermethrin, bethoxazin, BHC, bialaphos, bicyclopyrone, bifenazate, herbicide ether Bifenox), bifenthrin, bifujunzhi, bilanofos, binapacryl, bingqingxiao, bioallethrin, benzethrin Bioethanomethrin), biopermethrin, bioresmethrin, biphenyl, bisazir, bismerthiazol, bismerthiazol-copper, diphenyl Bismumermer methyl (i-naphthalene-y-sulphonate), bispyribac, bistrifluron, insecticidal double Bisultap), bitertanol, bithionol, bixafen, blasticidin-S, borax, Bordeaux mixture, boric acid, white Boscalid, BPPS, brassinolide, brassinolide-ethyl, brevisible pheromone (brevicomin), bromine Brodifacoum, brofenprox, brofenvalerate, broflanilide, brofluthrinate, bromacil, bromadiolone, two Bromchlophos, bromethalin, bromethrin, bromfenvinfos, bromoacetamide, bromobonil, bromobutachlor ( Bromobutide), bromociclen, bromocyclen, bromine-drip (DDT), bromofenoxim, bromophos, bromomethane, bromophos, B B-bromopropylate, bromopropylate, bromothalonil, bromoxynil, brompyrazon, bromuconazole, bronopol, BRP, BTH, bucarpolate, bufencarb, buminafos, bupirimate, buprofezin, Burgundy, busulfan (busulfan), busulphan, butacarb, butachlor, butafenacil, pasture Butam, butamifos, butane-fipronil, butathiofos, butenachlor, butane-fipronil Butethrin, buthidazole, buthiobate, buthiuron, butifos, butocarboxim, butonate, avoidance Butopyronoxyl, butoxycarboxim, butralin, butroxydim, buturon, butylamine, butyrate, butyrate (butylchlorophos), butylene-fipronil, cacodylic acid, cadusafos, cafenstrole, calciferol, calcium arsenate , calcium chlorate, calcium cyanamide, calcium cyanide, calcium polysulfide, calvinphos, cambendichlor, camphechlor, camphor, tetrachloro Captafol, captan, (carbam), carbamorph, carbanolate, carbaril, carbaryl, Carbasulam, carboathion, carbendazim, carbendazol, carbeamide, carbofenotion, carbofuran, carbon disulfide , carbon tetrachloride, carbonyl sulfide, carbophenothion, carbophos, carbosulfan, carboxazole, carboxide ), carboxin, carfentrazone, carpropamid, cartap, carvacrol, carvone, CAVP, CDAA, CDEA, CDEC , cellocidin, CEPC, ceralure, cerenox, cevadilla, Cheshunt mixture, chinalphos, Aikas -methyl (chinalphos-méthyl), chinomethionat, chinomethionate, chiralaxyl, chitosan, chlobenthiazone, methoxy Valley Chlomethoxyfen), chloralose, chloramben, chloramine phosphorus, chloramphenicol Amphonicol), chloraniformethan, chloranil, chloranocryl, chlorantraniliprole, chlorazifop, chlorazine, chlorbenside ), chlorbenzuron, chlorbicyclen, chlorbromuron, chlorbufam, chlordane, chlordecone, chlordimeform , chlorempenthrin, chloretazate, chlorethephon, chlorethoxyfos, chloreturon, chlorfenac, chlorfenapyr , 2-(2-chlorophenyl)-1H-chlorfenazole, chlorfenethol, chlorfenidim, chlorfenprop, chlorfenson, diazepam (chlorfensulphide), chlorfenvinphos, chlorfenvinphos-methyl, chlorfluazuron, chlorflurazole, chlorflurecol, chlorofluren , chloroflurenol, chloridazon, chloropyram Chlorimuron, chlorinate, chlor-IPC, chlormephos, chlormequat, chlormesulone, chlormethoxynil ), chlornidine, chlornitrofen, chloroacetic acid, chlorobenzilate, chlorodinitronaphthalene, chlorofénizon, chloroform, cockroach ( Chloromebuform), chloromethiuron, chloroneb, chlorophacinone, chlorophos, chloropicrin, chloropon, dextrorotatory Transchloropyrrolthrin, chloropropylate, chlorothalonil, chlorotoluron, (chloroxifenidim), chloroxuron, hydroxyxynil ), chlorphonium, chlorphoxim, chlorprazophos, chlorprocarb, chlorpropham, chlorpyrifos, chlorpyrifos-methyl Tetrachloroquine Chlorquinox, chlorsulfuron, chlorthal, chlorthiamid, chlorthiophos, chlortoluron, chlozolinate, chltosan , cholecalciferol, choline chloride, chromafenozide, cicloheximide, cimectacarb, cimetacarb, cinerin I, Guamethrin II, cinerins, cinidon-ethyl, cinmethylin, cinosulfuron, cintofen, benzalkonium Ciobutide, cisanilide, cismethrin, clacyfos, clefoxydim, clenpirin, clenprolin (clenpyrin), clethodim, climbbazole, cloodinate, clodinafop, cloethocarb, clofencet, clofenotane , clofentezine, clofenvinfos, clofibric acid, clofop, clomazone ), clomeprop, clonitralid, cloprop, cloproxydim, clopyralid, cloquintocet, chlorsulfuron Amine (cloransulam), closantel, clothianidin, clatumrimazole, cloxyfonac, cloxylacon, clozylacon, CMA , CMMP, CMP, CMU, dodecadienol (codlelure), colecalciferol, colophonate, copper 8-quinolinolate, copper acetate, acetamidine Copper arsenite, copper arsenate, copper carbonate, basic, copper hydroxide, copper naphthalate, copper oleate, copper oxychloride, copper ruthenate, copper sulfate, copper sulfate, basic, copper zinc chromate, chlorine Coumachlor, coumafène, coumafos, coumafuryl, coumaphos, coumatetralyl, coumethoxystrobin, Coumithoate, coumoxystrobin, CPMC, CPMF, CPPC, cedazine, cresol, cresylic ac Id), methylcrimidine, crotamiton, crotoxyfos, crotoxyphos, crufomate, cryolite, fly ketone (cue-lure), cufraneb, cumyleron, cumyluron, cuprobam, cuprous oxide, curcumenol, CVMP, cyanamide, cyanide Cyanatryn, cyanazine, cyanofenphos, cyanide, cyanophos, cyanthoate, cyantraniliprole, cyanuric acid, racer (cyazofamid), cybutryne, cyclafuramid, cyclanilide, cyclaniliprole, cyclethrin, cycloate, Cycloheximide, cycloprate, cycloprothrin, cyclopyrimorate, cyclosulfamuron, cyclooxydim, cyclocyclon ), cyenopyrafen, cyflufenamid, cyflumetofen, cyfluthrin, chlorofluorocyanate Cyhalodiamide, cyhalofop, cyhalothrin, cyhexatin, cymiazole, cymoxanil, cyometrinil, vodidine (cypendazole), cypermethrin, cyperquat, cyphenothrin, cyprazine, cyprazole, cyproconazole, cypro (cyprodinil), cyprofuram, cypromid, cyprosulfamide, cyromazine, cythioate, cytrex, ticks Long (daimuron), and pulled the present (dalapon), butoxy acyl hydrazine (daminozide), juvenile pyridazin ketone (dayoutong), Myron (dazomet), DBCP, d - camphor (d -camphor), DCB, DCIP , DCPA ( Japan ), DCPA (USA), DCPTA, DCU, DDD, DDPP, DDT, DDVP, debacarb, decafentin, decamethrin, decarbofuran , deetamine, dehydroacetic acid, deiquat, delachlor, delnav, deltamethrin, demephion Methyl chlorpyrifos-O, methyl chlorpyrifos-S, demeton, methyl endogenous phosphorus, endogenous phosphorus-O, methyl endophos-O, endogenous phosphorus-S, A Phosphorus-S, demeton-S-methyl sulphon, demeton-S-methylsulphon, DEP, depalléthrine, derris, beet desmedipham), diuron net (desmetryn), diuron net (desmetryne), d - trans-prallethrin (d -fanshiluquebingjuzhi), eliminating Fenlong (diafenthiuron), chloro phosphoramidite (dialifor), to give Larsson ( Dialifos), diallate, di-allate, diamidafos, dianat, diatomaceous earth, diatomite, diazinon , dibrom, dibutyl phthalate, dibutyl succinate, dicamba, dicapthon, dichlobenil, deichlofenthion, Dichlofluanid, dichlonone, dichloralurea, dichlorbenzuron, dichlorfenidim, dichlorflurecol, dichlorflureno l), dichlormate, dichlormid, dichloromethane, dichlorophen, 2,4-dipropionic acid, 2,4-dipropionic acid-P, Dichlorvos, dichlozolin, dichlozoline, diclobutrazol, diclocymet, diclofop, chlorpyrifos Diclomezine), dicloran, dicloromezotiaz, diclosulam, difofo, dicophane, dicoumarin Dicoumarol, dicresyl, dicrotophos, dicryl, dimumarin, dicyclanil, dicyclonon, dite Ld (dieldrin), dienochlor, diethamquat, diethatyl, diethion, diéthion, diethofencarb, di Dietholate, (diéthon), diethyl pyrocarbonate, diethyltoluamide, difenacoum, difenoconazole, pentylene Difenopenten, difenoxuron, difenzoquat, difethialone, flubenquinone (diflovidazin), diflubenzuron, diflufenican, diflufenicanil, diflufenzopyr, diflumetorim, dikegulac, two Dilor, dimatif, dimefluthrin, dimefox, Dimefuron, dimehypo, dimepiperate, dimetachlone, dimetan, dimethacarb, dimethachlone, dimethine Dimethachlor, dimethametryn, dimethenamid, chlorpyrifos-P, dimethipin, dimethirimol, dimethoate, up to Dimethomorph, dimethrin, dimethyl carbate, dithiodimethane, dimethyl decanoate, dimethylvinphos, dimetilan ), dimexano, dimidazon, dimoxystrobin, dimpylate, dimuron, dinex, pyridine oxazole Dingjunezuo), diniconazole, Dakli-M, dinitramine, dinitrophenol, dinobuton, dinocap, white powder gram-4, white powder gram-6, enemy Dinocton, dinofenate, dinopenton, dinoprop, dinosam, dinoseb, nitrenate acaricide (d Inosulfon), dinotefuran, dinoterb, dinoterbon, diofenolan, dioxabenzofos, dioxacarb, dioxathion ), dioxation, diphacin, diphacinone, diphenadione, diphenamid, diphenamide, diphenyl hydrazine, diphenylamine, Diphenylsulphide, diprogulic acid, dipropalin, dipropetryn, dipterex, dipymetitrone, dithiopyridinium (dipyrithione), diquat, disodium tetraborate, disosultap, disparlure, disugran, disul, disulfide Disulfiram), disulfoton, ditalimfos, dithianon, dithicrofos, disulfide, dithiométon, dithiopyr, Diuron, dixanthogen, d-limonene, DMDS, DMPA, DNOC, Twelve Rings Dodemorph, dodicin, dodine, dofenapyn, doguadine, dominicalure, doramectin, DPC , drazoxolon, DSMA, d-trans-allethrin, d-trans-resmethrin, dufulin, Dymron, EBEP, EBP, ebufos, ecdysterone, echlomezol, EDB, EDC, EDDP, edifenphos, eglinazine , emamectin, EMPC, empenthrin, enadenine, endosulfan, endothal, endothall, endophos ), endrin, enestroburin, enilconazole, enoxastrobin, ephirsulfonate, EPN, propionene lactone (epocholeone) ), epofenonane, epoxiconazole, eprinomectin, epronaz, epsilon-metofluthrin, ε-oxybenzyl Fluor (epsilon-momfluorothrin), EPTC, erbon, ergocalciferol, erlujixiancaoan, esdépalléthrine, esfenvalerate, ESP , esprocarb, etacelasil, etaconazole, etaphos, etem, ethaboxam, ethachlor, B Ethalfluralin, ethametsulfuron, ethaprochlor, ethephon, ethidimuron, ethiofencarb, ethiolate, Ethion, ethiozin, ethiprole, ethirimol, ethoate-methyl, ethobenzanid, yibend ( Ethofumesate), ethohexadiol, ethoprop, ethoprophos, ethoxyfen, ethoxyquin, ethoxysulfuron, Ethylchlozate, ethyl formate, ethyl pyrophosphate, ethylan , ethyl-DDD, ethylene, ethylene dibromide, ethylene dichloride, ethylene oxide, ethylicin, ethyl mercury 2, 3-dihydroxypropyl thiol ester (ethylmercury 2, 3-dihydroxypropyl Mercapride), ethylmercury acetate, ethylmercury bromide, ethyl mercuric chloride, ethyl mercury phosphate, etinofen, ETM, etnipromid, Etobenzanid, etofenprox, etoxazole, etridiazole, etrimfos, étrimphos, eugenol, EXD, famoxadone, famphur, fenac, fenamidone, fenaminosulf, fenaminstrobin, fenamiphos ), fenapanil, fenarimol, fenasulam, fenazaflor, fenazaquin, fenbuconazole, fenbutatin Oxide), fenchlorazole, fenchlorphos, fenchlorfos, fenclorim, fenethacar b), fenfluthrin, fenfuram, fenhexamid, fenidin, fenitropan, fenitrothion, fentanyl Ester (fénizon), fenjuntong, fenobucarb, fenolovo, 2,4,5-propionic acid (fenoprop), fenothiocarb (fenothiocarb), fenthene Nine (fenoxacrim), fenoxanil, fenoxaprop, fennelin-P, fenoxasulfone, fenoxycarb, fenpiclonil, pyrethrin ( Fenpirithrin), fenpropathrin, fenpropidin, fenpropimorph, fenpyrazamine, fenpyroximate, fenquinotrione, cockroach Fenridazon, fenson, fensulfothion, fenteracol, fenthiaprop, fenthion, fenthion-ethyl ), fentiaprop, fentin, fentrazamide, fentrifanil, fenuron, non Long TCA, fenvalerate, ferbam, ferimzone, ferrous sulfate, fipronil, flamprop, wheat fluoroester-M, volts Flazasulfuron, flocoumafen, flometoquin, flonicamid, florasulam, fluacrypyrim, dextrorotatory chloropropyne Fluezaindolizine, fluazifop, fluazifop-P, fluazinam, fluazolate, fluzuron, fluoride Flubendiamide, flubenzimine, flubrocythrinate, flucarbazone, flucetosulfuron, fluchloralin, flucofuron , flucycloxuron, flucythrinate, fludioxonil, fluénéthyl, fluenetil, fluensulfone, flufenacet ), flufenerim, flufenican, flufenoxuron, flufenoxystrobin, trifluoro Permethrin (flufenprox), fluoropyridazine Flufenpyr, flufenzine, flufiprole, fluhexafon, flumethrin, flumetover, flumetalin ), flumetsulam, flumezin, flumiclorac, flumioxazin, flumipropyn, fluoride Flumorph, fluometuron, fluopicolide, fluopyram, fluorbenside, fluoridamid, fluoroacetamide, Fluoroacetic acid, fluorochloridone, fluorodifen, fluoroglycofen, fluoroimide, fluoromide, Fluoromidine, fluoronitrofen, fluoroxypyr, fluothiuron, fluotrimazole, fluoxastrobin, fluoxazole (flupoxam), flupropacil, flupropadine, flupropanate, flupyradifurone, flupyrsulfuron, fluoroquinazole (fluquinconazole), fluralaner, flurazole, flurecol, flurenol, fluridone, flurochloridone, chlorofluorocarbon Fluromidine, fluroxypyr, flurprimidol, flufenamide (flu) Rsulamid), flurtamone, flusilazole, flusulfamide, flutenzine, fluthiacet, fluthiamide, fluphene (flutianil), flutolanil, flutriafol, fluvalinate, fluxametamide, fluxapyroxad, fluxofenim, Stempel, folfet, fomesafen, fonofos, foramsulfuron, forchlorfenuron, formaldehyde, formetanate , formothion, formparanate, fosamine, fosetyl, fosmethilan, fospirate, fosthiazate ), fosthietan, frontalin, fthalide, fuberidazole, fucaojing, fucaomi, flufenicol (fujunmanzhi), fulumi, fumarin, funaihecaoling, fuphenthiourea, ethylene Furalane, furalaxyl, furamethrin, furametpyr, furan tebufenozide, furathiocarb, xyfuramide (furcarbanil), furconazole, furconazole-cis, furethrin, furfural, furilazole, furmecyclox, furfuryl Furophanate, furyloxyfen, γ-BHC, gamma- cyhalothrin, γ-HCH, genit, gibberellic acid, red A3 (gibberellin A3), gibberellins, gliftor, glitor, glucochloralose, glufosinate, glufosinate-P, solid Glyondin, glyoxime, glyphosate, glyphosine, gossyplure, grandlure, griseofulvin Griseofulvin), guanoctine, guazatine, halacrinate, haloxifen, halfenprox, Halofenozide, halosafen, halosulfuron, haloxydine, haloxyfop, chlorofluoro-P, chlorofluoro-R, HCA, HCB, HCH, hemel, hempa, HEOD, heptachlor, heptafluthrin, heptenophos, heptopargil, avermectin Herbimycin), herbimycin A, heterophos, hexachlor, hexachloran, hexachloroacetone, hexachlorobenzene, hexachlorobutane Ethene, hexachlorophene, hexaconazole, hexaflumuron, hexafluoramin, hexaflurate, hexalure, hexamide , hexazinone, hexylthiofos, hexythiazox, HHDN, holosulf, homobrassinolide, huancaiwo, ringworm Nitrile (huanchongjing), huangcaoling, huanjunzuo, hydramethylnon, hydrargaphen, slaked lime Hydred lime), hydrogen cyanamide, hydrogen cyanide, hydroprene, hydroxyisoxazole, hymexazol, hyquincarb, IAA , IBA, IBP, icaridin, imazalil, imazamethabenz, imazamox, imazapic, imazapyr, Imazaquin, imametapyryr, imazosulfuron, imibenconazole, imikilinos, imidacloprid, imidaclothiz , iminoctadine, imiprothrin, inabenfide, indanofan, indaziflam, indoxacarb, inezin , infusorial earth, iodobonil, iodocarb, iodofenphos, iodomethane, iodosulfuron, iofensulfuron, Ioxybenil, ipazine, IPC, ipconazole, ipfencarbazone, C Iprobenfos, iprodione, iprovalicarb, iprymidam, ipsdienol, ipsenol, IPSP, IPX, yi Isofidofos, isazofos, isobenzan, isocarbamid, isocarbamide, isocarbophos, isocil, Isochloropurine (isodrin), isofenphos, methyl sulfasin, isofetamid, isolam, iso Isomethiozin, isororuron, isopamphos, isopolinate, isoprocarb, isoprocil, isopropalin, Isopropazol (isopropazol), isoprothiolane, isoproturon, isopyrazam, isopyrimol, isothioate, isotianil ( Isotianil), isouron, isovaledione, different Isoxaben, different Isoxachlortole, isoxadifen, different Isooxaflutole, different Isoxapyrifop, isoxathion, isuron, ivermectin, different Ixoxaben, izopamfos, izopamphos, japonilure, japothrins, jasmolin I, methocyanin II , jasmonic acid, jiahuangchongzong, jiajizengxiaolin, jiaxiangjunzhi, jiecaowan, jiecaoxi, jinggangmycin A (Jinganmycin A), retaining loose particles (jodfenphos), juvenile hormone I (juvenile hormone I), juvenile hormone II, juvenile hormone III, thiophene ah permethrin (kadethrin), κ- Bifen Ning (kappa -bifenthrin), κ- elimination Kappa- tefluthrin, karbutilate, karetazan, kasugamycin, kejunlin, kelevan, ketospiradox, Kieselguhr, kinetin, kinoprene, kiralaxyl, kresoxim-methyl, kuicaoxi, flucene Lactofen, lambda-cyhalothrin, latilure, lead arsenate, lenacil, lieutenant Lepimectin, leptophos, linbenjingzhi, lime sulfur, lindane, lineatin, linuron, force pine (lirimfos), litlure, looplure, lufenuron, chlorofluorocyanamide, lüxiancaolin, lüxiancaolin, lvdingjunzhi , flufenthrin (lvfumijvzhi), lvxiancaolin, lythidathion, M-74, M-81, MAA, magnesium phosphide, marathion, maldison, cis Maleic hydrazide, malonoben, maltodextrin, MAMA, mancopper, mancozeb, mandestrobin, Mandipropamid, maneb, matrine, mazidox, MCC, MCP, MCPA, thioethyl MCPA, MCPB, MCPP, mebenil, Mecarbam, mecarbinzid, mecarphon, mecoprop, 2-methyl-4-chloropropionic acid-P, acaricidal Medimeform), Medinoterb, medlure, mefenacet, mefenoxam, mefenpyr, mefluidide, tetradecadienoic acid (megatomoic acid), beeswaxol, melitoxin, MEMC, menazon, MEP, mepanipyrim, meperfluthrin, mephenate , mephosfolan, mepiquat, mepronil, meptyldinocap, mercaptodimethur, mercaptophos, mercaptophos thiol, horse Mercaptothion, mercuric chloride, oxidized mercury, mercurous chloride, merphos, merphos oxide, mesoprazine, mesosulfuron, sulphur Mesotrione, mesulfen, mesulfenfos, mesulphen, metacresol, metaflumizone, metalaxyl, Right metalaxyl-M, metaldehyde, metam, Zolamapamine, benzene Metaamitron, metaphos, metaxon, metazachlor, metazosulfuron, metazoxolon, thiophene (metconazole), metepa, metflurazon, methabenzthiazuron, metacrifos, methalpropalin, weibaimu ( Metham), methamidophos, methasulfocarb, methazole, methfuroxam, methimenzuron, methidathion, methotrexate (methiobencarb), methiocarb, methiopyrisulfuron, methiotepa, methiozolin, methiuron, methocrotophos , métholcarb, metometon, methomyl, metoprene, mesoprotryn, methoprotryne, quinolinecarboxylic acid-butyl ( Methoquin-butyl), metothrin, methoxychlor, methoxyfenozide, Methoxyphenone, methyl apholate, methyl bromide, methyl eugenol, methyl iodide, methyl isothiocyanate, methyl baba Methyl parathion, methylacetophos, methyl chloroform, methyldithiocarbamic acid, methyldymron, methylene chloride, methyl fenfensone (methyl- Isofenphos), methylmercaptophos, methylmercaptophos oxide, methylmercaptophos thiol, methylmercury benzoate, methylmercury benzoate (methylmercury dicyandiamide), methylmercury pentachlorophenoxide, methylneodecanamide, methylnitrophos, methyltriazothion, metiuzolin Meirm, free of metiram-zinc, metobenzuron, metobromuron, metofluthrin, metolachlor, metolcarb Tribenuron (metometuron), metominostrobin (metominostrobin), metosulam (metosulam), Metoxadiazone, metoxuron, metrafenone, metriam, metribuzin, metrifonate, metriphonate, thiabium Amine (metsulfovax), metsulfuron, mevinphos, mexacarbate, miechuwei, mieshuan, miewenjuzhi, milbemectin ), milbemycin oxime, milneb, mimanan, mipafox, MIPC, mirex, MNAF, moguchun, rice Molten, molosultap, momfluorothrin, monalide, monisuron, monoamitraz, monochloroacetic acid, arsenic Monocrotophos, monolinuron, monomehypo, monosulfiram, monosulfuron, monosultap, monuron, herbicide TCA, morfamquat, moroxydine, morphothion, morzid, moxidectin, MPMC, MSMA MTMC, muscalure, myclobutanil, myclozolin, myricyl alcohol, N-(ethylmercury)-p-toluenesulfonamide, NAA, NAAm, Nabam, naftalofos, naled, naphthalene, naphthylamine, naphthalic anhydride, naphthalophos, naphthyloxyacetic acid, naphthaleneacetic acid , naphthylindane-1,3-diones, naphthyloxyacetic acids, naproanilide, napropamide, napropamide -M), naptalam, natamycin, NBPOS, neburea, neburon, nendrin, neonicotinoid, nikonfos ), niclofen, niclosamide, nicofifen, nicosulfuron, nicotine, nicotine sulfate, nifluridide, nick Nikkomycins, NIP, nipyraclofen, nipyralofen, nitenpyram, nithiazine, killing Nitralin, nitrapyrin, nitrilacarb, nitrofen, nitrofluorfen, nitrostyrene, nitrothal-isopropyl, mouse Nobormide, sterol, norbormide, norea, norflurazon, nornicotine, noruron, novaluron , polyfluuron (noviflumuron), NPA, nuarimol, nuranone, OCH, octachlorodipropyl ether, octhiminone, o-dichlorobenzene, fur Ofurace, omethoate, o-phenylphenol, orbencarb, orfralure, orthobencarb, ortho-dichlorobenzene, Orthosulfamuron, oryctalure, oressastrobin, oryzalin, osthol, osthole, ostramone ), ovatron, ovex, oxabetrinil, propyne Oxadiargyl, oxadiazon, oxadixyl, oxamate, oxamyl, oxapyrazon, oxapyrazone, ring Oxalsulfuron, oxathiapiprolin, Oxaziclomefone, oxine-copper, oxine-Cu, oxolinic acid, Oxpoconazole, oxycarboxin, oxydemeton-methyl, oxydeprofos, oxydisulfoton, oxyenadenine, oxyfluorfen, oxidation Oxymatrine, oxytetracycline, oxythioquinox, PAC, paclobutrazol, paichongding, palléthrine, PAP, p-dichlorobenzene (para-dichlorobenzene), parafluron, paraquat, parathion, methylbalazon, parinol, Paris green, PCNB, PCP , PCP-Na, p-dichlorobenzene, PDJ, pebulate, pédinex, pefurazoate, pelargonic acid, pingke ( Penconazole), pencycuron, pendimethalin, penfenate, penflufen, penfluron, penoxalin, flat rot Penoxsulam), pentachlorophenol, pentachlorophenyl laurat, chlorpyrifos (pe) Ntanochlor), penthiopyrad, pentmethrin, cyclopentane Pentoxazone, perchlordecone, perfluidone, permethrin, pethoxamid, PHC, phenamacril, ethyl cyanobacteria Amine (phenamacril-ethyl), phénaminosulfate, phenazine oxide, phénétacarbe, phenisopham, phenkapton, phenmedipham, Ethyl beetine, phenobenzuron, phenothiol, phenothrin, phenproxide, phenthoate, phenylmercuriurea, benzene Phenylmercury acetate, phenylmercury chloride, phenylmercury derivative of pyrocatechol, phenylmercury nitrate, phenylmercury salicylate (phenylmercury salicylate), phorate, phosacetim, phosalone, phosametine, phosazetim, phosazetin, triphosphorus ( Phoscyclotin), phosdiphen, phosphos l), phosfolan, phosfolan-methyl, phosglycin, phosmet, phosnichlor, phosphamide ), phosphamidon, phosphine, phosphinothricin, phosphocarb, phosphorus, phostin, phoxim, methyl basalson, ferrets Phthalide), phthalophos, phthalthrin, picarbutrazox, picaridin, picloram, picolinafen, pyridine Picoxystrobin, pimaricin, pindone, pinoxaden, piperalin, piperazine (piperazine), piperonyl butoxide, piperonyl cyclonene, piperophos, piproctanly, piproctanyl, piprotal, piprotal Pirametaphos, pirimicarb, piriminil, pirimioxyphos, pirimiphos-ethyl, pirimiphos-methyl, murmurone (pival) ), pivaldione, plifenate, PMA, PMP, polybutenes, polycarbamate, polychlorcamphene, polyethylidene Polyethoxyquinoline, polyoxin D, polyoxins, polyoxorim, polythialan, potassium arsenite , potassium azide, potassium cyanate, potassium ethyl xanthate, potassium naphthenate, potassium polysulfide, potassium thiocyanate , 4,4-DDT (pp '-DDT), Puyaliening (prallethrin), Precocene I (precocene I),熟素 II, presenilin III, pretilachlor, primidophos, primisulfuron, probenazole, prochloraz, proclonol, propionitrile Procyazine, procymidone, prodiamine, profenofos, profluazol, profluralin, profluthrin, chlorine Profoxydim, (profurite-aminium), proglinazine, prohexadione, prohydrojasmon, promacyl, promecarb, extinguish Prometon, prometryn, prometryne, promurit, pronamide, propachlor, propafos, propazone (propamidine), propamocarb, propanil, propaphos, propaquizafop, propargite, proparthrin, propazine , propetamphos, propham, propiconazole, propidine, a Propineb, propisochlor, propoxur, propoxycarbazone, propyl isome, Propyrisulfuron, propyzamide, proquinazid, prosuler, prosulfalin, prosulfocarb, trifluoropropane Prosulfuron, prothidathion, prothiocarb, prothioconazole, prothiofos, prothoate, protrifenbute, Proxan, prymidophos, prynachlor, psoralen, psoralene, pydanon, flubenazole hydroxylamine (pydiflumetofen), pyflubumide, pymetrozine, pyracarbolid, pyraclofos, pyraclonil, pyraclostrobin, pyraflufen ), pyrafluprole, pyramat, pyrametostrobin, pyraoxystrobin, pyrasulfyrazole, pyrazilflumid, pyrazolate , pyrazolynate, pyrazon, pyrazophos, baisulong (p Yrazosulfuron), pyrazothion, pyrazoxyfen, pyresmethrin, pyrethrin I, pyrethrin II, pyrethrin, grass ether-isopropyl (pyribambenz -isopropyl),pyribambenz-propyl,pyribencarb,pyribenzoxim,pyributicarb,pyriclor,pyridaben ), pyridafol, pyridalyl, pyridaphenthion, pyridaphenthione, pyridate, pyridinitril, bifenofol ( Pyrifenox), pyrifluquinazon, pyrifalid, pyrimétaphos, pyrimethanil, pyrimicar, pyrimidifen, pyrimethazine Pyrimanobac, pyrimiminostrobin, pyrimiphos-éthyl, pyrimiphos-méthyl, pyrimisulfan, pyrimimate, rodenticide (pyrinuron), pyrifenone, pyriprole, pyripolol, pyrip Roxyfen), pyrisoxazole, pyrithiobac, pyrolan, pyroquilon, pyroxasulfone, pyroxulam, chlorine Pyroxychlor, pyroxyfur, qincaosuan, qingkuling, quassia, quinacetol, quinalphos, methyl Yusong, quinazamid, quinclorac, quinconazole, quinmerac, quinoclamine, quinomethionate, chloramphenicol (quinonamid), quinothion, quinoxyfen, quintiofos, quintozene, quizalofop, sorghum-P, mosquito repellent (quwenzhi) ), Quyingding, Rabenzazole, Rafoxanide, R-diniconazole, Rebemide, Reglone, Resveratrol (renriduron), rescalure, resmethrin, rhodetanil, rhodopaponin-III, virus (ribavirin), rimsulfuron, rizazole, R-metalaxyl, rodentanamine, ronnel, rotenone, blue Ryania, sabadilla, saflufenacil, saijunmao, saisentong, salicylamine, salifluofen, blood root Alkali (sanguinarine), santonin, S-bioallethrin, schradan, scilliroside, sebuthylazine, secbumeton , sedaxane, selamectin, semiamitraz, sesamex, sesamolin, sesone, sethoxydim, west Sevin, shuangjiaancaolin, shuangjianancaolin, S-hydroprene, siduron, sifumijvzhi , siglure, silafluofen, silatrane, silica aerogel, silicone, silthiofam ), silthiopham, silthiophan, 2,4,5-propionic acid (silvex), simazine, simeconazole, simeton ), simetryn, simetryne, sintofen, S-kinoprene, slaked lime, SMA, S-Missing (S -methoprene), S-metolachlor, sodium arsenite, sodium azide, sodium chlorate, sodium cyanide, sodium fluoride, sodium fluoroacetate, sodium hexafluoroantimonate, sodium naphthenate (sodium naphthenate), sodium o-phenylphenoxide, sodium orthophenylphenoxide, sodium pentachlorophenate, sodium pentachlorophenoxide, sodium polysulfide (sodium polysulfide), sodium silicofluoride, sodium tetrathiocarbonate, sodium thiocyanate, solan, sophamide, spinetoram, Spinosad, spirodiclofen, spiromesifen, spirotetramat, spiroxamine Stirofos, streptomycin, strychnine, sulcatol, sulcofuron, sulcotrione, sulfallate ), sulfentrazone, sulfiram, sulfluramid, sulfodiazole, sulfometuron, sulfosate, sulfonamide (sulfosulfuron), sulfotep, sulfotepp, sulfoxaflor, sulfoxide, sulfoxime, sulfur, sulfuric acid, sulfonium fluoride, sulphon Sulkglycapin, sulphosate, sulprofos, sultropen, swep, tau- fluvalinate, tavron , tizimcarb, TBTO, TBZ, TCA, TCBA, TCMTB, TCNB, TDE, tebuconazole, tebufenozide, tebufenpyrad, isobutyl quinolate (tebufloquin) ), tebupirimfos, tebutam, tebuthiuron, tecloftalam, tecnazene, blessing Double (tecoram), dicion, teflubenzuron, tefluthrin, tefuryltrione, tembotrione, tefefos , temephos, tepa, TEPP, tepraloxydim, teproloxydim, terallethrin, terbacil, special grass Terbucarb, terbuchlor, terbufos, terbumeton, terbuthylazine, terbutol, terbutryn, terding (terbutryne), terraclor, terramicin, terramycin, tetcyclacis, tetrachloroethane, tetrachlorvinphos, four Tetraconazole, tetradifon, tetradisul, tetrafluron, tetramethrin, tetramethylfluthrin, tetraamine, chlorpyrifos ( Tetranactin), tetraniliprole, tetrapion, tetrasul, thallium sulfate , thallous sulfate, thenylchlor, cypermethrin, thiabendazole, thiacloprid, thiazepine (thiadiazine), thiadifluor, thiamethoxam, thiameturon, thiapronil, thiazafluron, thiazfluron, thiazone, Thiazopyr, thicrofos, thicyofen, thidiazimin, thidiazuron, thiencarbazone, thifensulfuron ( Thifensulfuron), thifluzamide, thimerosal, thimet, thiobencarb, thiocarboxime, thiochlorfenphim, sulphur Thiochlorphenphime, thiocyanatodinitrobenzenes, thiocyclam, thiodan, thiodiazole-copper, thiodicarb, long-lasting effect Thiofanocarb, thiofanox, thiofluoximate, thiohempa, thiomersal, thiometon, thionazin, multi-protective Thiophanate), thiophanate-ethyl, thiophanate-methyl, pair Thiophos, thioquinox, thiosemicarbazide, thiosultap, thiotepa, thioxamyl, thiram, thiram (thiuram), thuringiensin, tiabendazole, tiadinil, tiafenacil, tiaojiean, TIBA, thiatol ), tiocarbazil, tioclorim, tioxazafen, tioxymid, tirpate, TMTD, tolclofos-methyl, detached Tolfenpyrad, tolprocarb, tolpyralate, tolyfluanid, tolylfluanid, tolyl acetic acid, tomarin , topramezone, toxaphene, tPN, tralkoxydim, tralocythrin, tralmethrin, tramopyril, bewunning (transfluthrin), transpermethrin, tretamine, triacontanol, triadimef On), triadimenol, triafamone, triallate, tri-allate, triamiphos, triapenthenol, three Triarathene, triarimol, triasulfuron, triazamate, triazbutil, three Triaziflam, triazophos, triazothion, azathionas (triazoxide), tribasic copper chloride, tribasic copper sulfate, tribenuron, tribufos, tributyltin oxide, tricamba, Tricholamide, trichlopyr, trichlorfon, trichlormetaphos-3, trichloronat, trichloronate, triclosan Trichlorotrinitrobenzenes, trichlorphon, triclopyr, triclopyricarb, tricresol, tricyclazole, tricyclohexyltin hydroxide (trichlorotrinitrobenzenes), trichlorphon (trichlorophon), triclopyricarb (triclopyricarb), tricresol (triresol), tricyclazole (tricyclazole) Tricyclohexyltin hydroxide), tridemorph, tridiphane, trietazine, trifenmorph, trifenofos, trifloxystrobin, trifluoro Trifloxysulfuron, trifludimoxazin, triflumezopyrim, triflumizole, triflumuron, trifluralin, fluamine Triflusulfuron, trifop, Fluoro grass oxime (trifopsime), Sai Funing (triforine), trihydroxytriphenylmethane , trimedlure, trimethacarb, trimeturon, trinexapac, triphenyltin, triprene, tripropindan , triptolide, tritac, trithialan, triticonazole, tritosulfuron, trunc-call, defoliation (tuoyelin), uniconazole, uniconazole-P, urbacide, uredepa, valerate, validamycin, Validamycin A, valifenalate, valone, vamidothion, vangard, vaniliprole, vernolate ), vinclozolin, vitamin D3, warfarin, xiaochongliulin, xinjunan, xiwojunan, enestrobin (xiwojunzhi), XMC, xylachlor, xylenols, xylylcarb, xymiazole, yishijing, cyanide Amine (zarilamid), zeatin, zengxiaoan, zengxiaolin, zeta-cypermethrin, zinc naphthalate, zinc phosphide, zinc thiazide (zinc thiazole), zinc thiozole, zinc trichlorophenate, zinc trichlorophenoxide, zineb, ziram, zolaprofos, Zoocoumarin, zoxamide, zuoanjunzhi, zuocaoan, zuojunzhi, zuomihuanglong, α-chlorohydrin Α-chlorohydrin, α-ecdysone, α-multistriatin, α-naphthaleneacetic acid, and β-ecdysone; (2 ) following molecule (a) N- (3- chloro-l- (pyridin-3-yl) lH-pyrazol-4-yl) -N- ethyl-3 - ((3,3,3-trifluoro Propyl) thio)propanamide (hereinafter referred to as " AI-1 ") (b) (3S,6S,7R,8R)-8-Benzyl-3-(3-((isobutyloxy)methoxy)-4-methoxypyridinecarboxamido)-6 -Methyl-4,9-dioxo-1,5-dioxanthene-7-ylisobutyrate ((3S,6S,7R,8R)–8–benzyl–3–(3–(( Isobutyryloxy)methoxy)–4–methoxypicolinamido)–6–methyl–4,9–dioxo–1,5–dioxonan–7–yl isobutyrate) (hereinafter referred to as “ AI–2 ”) (3) A molecule called Lotilaner having the following structure And (4) the structure of the following molecular table A-M# -active ingredients in Table A

如在本揭露內容中使用，上文各者為一種活性成分。關於更多資訊，請查閱位於Alanwood.net 之“Compendium of Pesticide Common Names ”，及位於bcpcdata.com. 之“The Pesticide Manual ”之各種版本，包括在線版。As used in the disclosure, each of the above is an active ingredient. For more information, check out the " Compendium of Pesticide Common Names " at Alanwood.net and the various versions of " The Pesticide Manual " at bcpcdata.com .

特別佳的活性成分之選擇是1,3-二氯丙烯、陶斯松(chlorpyrifos)、六伏隆(hexaflumuron)、滅芬諾(methoxyfenozide)、多氟脲(noviflumuron)、賜諾特(spinetoram)、賜諾殺(spinosad)、氟啶蟲胺腈(sulfoxaflor)，以及磺醯氟(此後稱為“AIGA–2 ”)。Particularly preferred active ingredients are selected from the group consisting of 1,3-dichloropropene, chlorpyrifos, hexaflumuron, methoxyfenozide, noifurumuron, spinetoram, and Spinosad, sulfoxaflor, and sulfonium fluoride (hereinafter referred to as " AIGA-2 ").

此外，另一特別佳的活性成分之選擇是亞醌蟎(acequinocyl)、亞滅培(acetamiprid)、乙醯蟲腈(acetoprole)、阿維菌素(avermectin)、谷速松(azinphos-methyl)、必芬蟎(bifenazate)、畢芬寧(bifenthrin)、胺甲(carbaryl)、加保扶(carbofuran)、克凡派(chlorfenapyr)、克福隆(chlorfluazuron)、可芬諾(chromafenozide)、可尼丁(clothianidin)、賽扶寧(cyfluthrin)、賽滅寧(cypermethrin)、第滅寧(deltamethrin)、汰芬隆(diafenthiuron)、因滅汀苯甲酸鹽(emamectin benzoate)、安殺番(endosulfan)、益化利(esfenvalerate)、乙蟲腈(ethiprole)、依殺蟎(etoxazole)、芬普尼(fipronil)、氟尼胺(flonicamid)、嘧蟎酯(fluacrypyrim)、γ-賽洛寧(gamma -cyhalothrin)、合芬隆(halofenozide)、因得克(indoxacarb)、λ-賽洛寧(lambda -cyhalothrin)、祿芬隆(lufenuron)、馬拉松(malathion)、納乃得(methomyl)、諾伐隆(novaluron)、百滅寧(permethrin)、啶蟲丙醚(pyridalyl)、畢汰芬(pyrimidifen)、賜派芬(spirodiclofen)、得芬諾(tebufenozide)、賽果培(thiacloprid)、賽速安(thiamethoxam)、硫敵克(thiodicarb)、脫芬瑞(tolfenpyrad)，以及ζ-賽滅寧(zeta -cypermethrin) (此後稱為“AIGA–3 ”)。In addition, another particularly preferred active ingredient is acequinocyl, acetamiprid, acetoprole, avermectin, azinphos-methyl. , bifenazate, bifenthrin, carbaryl, carbofuran, chlorfenapyr, chlorfluazuron, chromafenozide, cotinine (clothianidin), cyfluthrin, cypermethrin, deltamethrin, diafenthiuron, emamectin benzoate, endosulfan , esfenvalerate, ethiprole, etoxazole, fipronil, flonicamid, fluacrypyrim, gamma-cylon ( gamma) -cyhalothrin), halofenozide, indoxacarb, lambda- cyhalothrin, lufenuron, malathion, methodill, novar Novaluron, permethrin, pyridalyl, pyrimidifen, schiffen (sp) Irodiclofen), tebufenozide, thiacloprid, thiamethoxam, thiodicarb, tolfenpyrad, and zeta- cypermethrin ( This is called " AIGA–3 ".

術語「烯基 」意指由碳及氫組成之非環狀、不飽和(至少一個碳-碳雙鍵)、分支鏈或未分支的取代基，例如乙烯基、烯丙基、丁烯基、戊烯基及己烯基。The term " alkenyl " means an acyclic, unsaturated (at least one carbon-carbon double bond), branched or unbranched substituent consisting of carbon and hydrogen, such as vinyl, allyl, butenyl, Pentenyl and hexenyl.

術語「烯氧基 」係指進一步由碳-氧單鍵組成之烯基，如烯丙基氧基、丁烯氧基、戊烯氧基、己烯氧基。The term " alkenyloxy " means an alkenyl group further composed of a carbon-oxygen single bond, such as allyloxy, butenyloxy, pentenyloxy, hexenyloxy.

術語「烷氧基 」係指進一步由碳-氧單鍵組成之烷基，如甲氧基、乙氧基、丙氧基、異丙氧基、丁氧基，以及三級丁氧基。The term " alkoxy " refers to an alkyl group further composed of a carbon-oxygen single bond, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, and tertiary butoxy.

術語「烷基 」係指由碳及氫組成之非環狀、飽和、分支鏈或未分支的取代基，例如甲基、乙基、丙基、異丙基、丁基及三級丁基。The term " alkyl " refers to acyclic, saturated, branched or unbranched substituents consisting of carbon and hydrogen, such as methyl, ethyl, propyl, isopropyl, butyl and tert-butyl.

術語「炔基 」意指由碳及氫組成之非環狀、不飽和(至少一個碳-碳參鍵)、分支鏈或未分支的取代基，例如乙炔基、炔丙基、丁炔基及戊炔基。The term " alkynyl " means an acyclic, unsaturated (at least one carbon-carbon ginseng), branched or unbranched substituent consisting of carbon and hydrogen, such as ethynyl, propargyl, butynyl and Pentynyl.

術語「炔氧基 」意指進一步由碳-氧單鍵組成之炔基，例如戊炔氧基、己炔氧基、庚炔氧基及辛炔氧基。The term " alkynyloxy " means an alkynyl group further composed of a carbon-oxygen single bond, such as a pentynyloxy group, a hexynyloxy group, a heptynyloxy group, and an octynyloxy group.

術語「芳基 」意指由氫及碳組成之環狀、芳香族取代基，例如苯基、萘基及聯苯。The term " aryl " means a cyclic, aromatic substituent consisting of hydrogen and carbon, such as phenyl, naphthyl and biphenyl.

術語「生物性殺蟲劑 」意指一種微生物型生物性害蟲防治劑，一般而言，係以與化學性殺蟲劑類似的方式來施用。通常其等為細菌型，但亦有真菌控制劑之實例，包括木黴屬(Trichoderma spp .)及白粉寄生孢(Ampelomyces quisqualis )。一種眾所周知的生物性殺蟲劑實例為芽孢桿菌屬(Bacillus )物種，其係一種鱗翅目(Lepidoptera)、鞘翅目(Coleoptera)及雙翅目(Diptera)之細菌性疾病。生物性殺昆蟲劑包括以下列為基礎之產物：昆蟲致病性真菌(如黑殭菌(Metarhizium anisopliae ))，昆蟲致病性線蟲(如蕪菁夜蛾斯氏線蟲(Steinernema feltiae ))，以及昆蟲致病性病毒(如蘋果蠹蛾(Cydia pomonella )顆粒體病毒)。昆蟲致病性生物體的其他實例包括但不限於桿狀病毒、原生動物及微孢子目(Microsporidia)。為了避免疑問，生物性殺蟲劑為活性成分。The term " biological insecticide " means a microbial type biological pest control agent, and is generally applied in a similar manner to a chemical insecticide. Usually they are of the bacterial type, but there are also examples of fungal control agents, including Trichoderma spp . and Ampelomyces quisqualis . An example of a well-known biological insecticide is the Bacillus species, which is a bacterial disease of the order Lepidoptera, Coleoptera, and Diptera. Biological insecticides include products based on insect pathogenic fungi (such as Metarhizium anisopliae ), insect pathogenic nematodes (such as Steinernema feltiae ), and insects. Pathogenic virus (such as Cydia pomonella granulosis virus). Other examples of insect pathogenic organisms include, but are not limited to, baculovirus, protozoa, and Microsporidia. For the avoidance of doubt, biological insecticides are active ingredients.

術語「環烯基 」意指由碳與氫組成之單環或多環、不飽和(至少一碳-碳雙鍵)取代基，例如環丁烯基、環戊烯基、環己烯基、降莰烯、雙環[2.2.2]辛烯基、四氫萘基、六氫萘基與八氫萘基。The term " cycloalkenyl " means a monocyclic or polycyclic, unsaturated (at least one carbon-carbon double bond) substituent consisting of carbon and hydrogen, such as cyclobutenyl, cyclopentenyl, cyclohexenyl, Decalene, bicyclo [2.2.2] octenyl, tetrahydronaphthyl, hexahydronaphthyl and octahydronaphthalenyl.

術語「環烯氧基 」係指更進一步由碳-氧單鍵組成之環烯基，例如環丁烯氧基、環戊烯氧基、降莰烯氧基，以及雙環[2.2.2]辛烯氧基。The term " cycloalkenyloxy " refers to a cycloalkenyl group further composed of a carbon-oxygen single bond, such as a cyclobutenyloxy group, a cyclopentenyloxy group, a norborneneoxy group, and a bicyclo[2.2.2] octane. Alkenyloxy.

術語「環烷基 」係指由碳與氫組成之單環或多環、飽和取代基，例如環丙基、環丁基、環戊基、降莰烯、雙環[2.2.2]辛基與十氫萘。The term " cycloalkyl " refers to a monocyclic or polycyclic, saturated substituent consisting of carbon and hydrogen, such as cyclopropyl, cyclobutyl, cyclopentyl, norbornene, bicyclo [2.2.2] octyl and Decalin.

術語「環烷氧基 」係指更進一步由碳-氧單鍵組成之環烷基，如環丙氧基、環丁氧基、環戊氧基、降莰烯氧基與雙環[2.2.2]辛基氧基。The term " cycloalkoxy " means a cycloalkyl group further composed of a carbon-oxygen single bond, such as cyclopropoxy, cyclobutoxy, cyclopentyloxy, norborneneoxy and bicyclo [2.2.2 ] octyloxy.

術語「鹵基 」係指氟、氯、溴與碘。The term " halo " means fluoro, chloro, bromo and iodo.

術語「鹵烷氧基 」係指一烷氧基，其進一步由一至最大可能數目之相同或相異之鹵素組成，如氟甲氧基、三氟甲氧基、2,2-二氟丙氧基、氯甲氧基、三氯甲氧基、1,1,2,2-四氟乙氧基與五氟乙氧基。The term " haloalkoxy " refers to alkoxy, which is further composed of one to the largest possible number of the same or different halogens, such as fluoromethoxy, trifluoromethoxy, 2,2-difluoropropoxy Base, chloromethoxy, trichloromethoxy, 1,1,2,2-tetrafluoroethoxy and pentafluoroethoxy.

術語「鹵烷基 」係指進一步由一至最大可能數目、相同或相異之鹵素組成之烷基，如氟甲基、三氟甲基、2,2-二氟丙基、氯甲基、三氯甲基與1,1,2,2-三氟乙基。The term " haloalkyl " refers to an alkyl group further composed of one to the largest possible number, the same or different halogens, such as fluoromethyl, trifluoromethyl, 2,2-difluoropropyl, chloromethyl, three Chloromethyl and 1,1,2,2-trifluoroethyl.

術語「雜環基 」意指可能為芳香族、完全飽和，或部分或完全不飽和的環狀取代基，其中該環狀結構含有至少一個碳及至少一個雜原子，其中該雜原子為氮、硫或氧。實例為：(1) 芳香性雜環 基 取代基 包括，但不限於苯并呋喃基、苯并異噻唑基、苯并異唑基、苯并噻吩基、苯并噻唑基、苯并唑基、啉基(cinnolinyl)、呋喃基、咪唑基、吲唑基、吲哚基、異吲哚基、異喹啉基、異噻唑基、異唑基、二唑基、唑啉基、唑基、呔基、吡基、吡唑啉基、吡唑基、嗒基、吡啶基、嘧啶基、吡咯基、喹唑啉基、喹啉基、喹喏啉基、四唑基、噻唑啉基、噻唑基、噻吩基、三基及三唑基；(2) 完全飽和之雜環基取代基 包括，但不限於：六氫吡基、哌啶基、嗎啉基、吡咯啶基、四氫呋喃基，及四氫哌喃基；(3) 部分或完全不飽和的雜環基取代基 包括，但不限於4,5-二氫-異唑基、、4,5-二氫-唑基、4,5-二氫-1H -吡唑基、2,3-二氫-[1,3,4]-二唑基，以及1,2,3,4-四氫喹啉基；以及(4) 額外的雜環基實例包括以下各者： 硫化三亞甲基         硫化三亞甲基-氧化物 硫化三亞甲基-二氧化物。The term " heterocyclyl " means a cyclic substituent which may be aromatic, fully saturated, or partially or fully unsaturated, wherein the cyclic structure contains at least one carbon and at least one hetero atom, wherein the hetero atom is nitrogen, Sulfur or oxygen. Examples are: (1) an aromatic heterocyclic group substituents include, but are not limited to, benzofuranyl, benzo isothiazolyl, benzo iso Azolyl, benzothienyl, benzothiazolyl, benzo Azolyl, Cinnolinyl, furyl, imidazolyl, oxazolyl, fluorenyl, isodecyl, isoquinolinyl, isothiazolyl, iso Azolyl, Diazolyl, Oxazolinyl, Azolyl, anthracene Base Base, pyrazolinyl, pyrazolyl, anthracene Base, pyridyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolyl, quinoxalinyl, tetrazolyl, thiazolinyl, thiazolyl, thienyl, tri And triazolyl; (2) fully saturated heterocyclic substituents including, but not limited to, hexahydropyridyl a base, piperidinyl, morpholinyl, pyrrolidinyl, tetrahydrofuranyl, and tetrahydropyranyl; (3) a partially or fully unsaturated heterocyclic substituent including, but not limited to, 4,5-dihydro- different Azolyl, 4,5-dihydro- Azyl, 4,5-dihydro-1 H -pyrazolyl, 2,3-dihydro-[1,3,4]- Examples of oxadiazolyl, and 1,2,3,4-tetrahydroquinolinyl; and (4) additional heterocyclic groups include the following: Trimethylidene sulfide Trimethylidene-oxide sulfide trimethylene-dioxide.

術語「所在地 」意指一棲息地、養育場、植物、種子、土壤、材料，或害蟲將生長或能走過之環境。舉例而言，所在地可為：生長中之農作物、樹木、水果、穀物、飼料種類、葡萄、草皮，及/或觀賞植物之處；圈養動物居住之處；建築之內部或外部表面(如儲存穀物之處)；建築內所使用之建構材料(如浸漬木材)；以及建築附近之土壤。The term " location " means a habitat, a nursery, a plant, a seed, a soil, a material, or an environment in which a pest will grow or pass. For example, the location may be: growing crops, trees, fruits, grains, feed types, grapes, turf, and/or ornamental plants; where captive animals live; interior or exterior surfaces of buildings (eg, storage of grain) Where)) construction materials used in the building (such as impregnated wood); and soil near the building.

用語「MoA 材料 」意指一種活性成分，其具有如同位於 irac-online.org.，IRAC MoA Classification v. 7.4中所示的作用模式(「MoA 」)，描述以下幾組。(1) 乙醯膽鹼酯酶(AChE) 抑制劑 ，包括下列活性成分：毆殺松(acephate)、棉鈴威(alanycarb)、得滅克(aldicarb)、亞滅松(azamethiphos)、乙基谷速松(azinphos-ethyl)、谷速松(azinphos-methyl)、免敵克(bendiocarb)、免扶克(benfuracarb)、佈嘉信(butocarboxim)、丁酮碸威(butoxycarboxim)、硫線磷(cadusafos)、胺甲(carbaryl)、加保扶(carbofuran)、丁基加保扶(carbosulfan)、氯氧磷(chlorethoxyfos)、氯芬松(chlorfenvinphos)、氯甲磷(chlormephos)、陶斯松(chlorpyrifos)、甲基陶斯松(chlorpyrifos-methyl)、蠅毒磷(coumaphos)、氰乃松(cyanophos)、甲基内吸磷-S、大利松(diazinon)、二氯松(dichlorvos)/DDVP、雙特松(dicrotophos)、大滅松(dimethoate)、二甲基亞硝胺(dimethylvinphos)、二硫松(disulfoton)、EPN、愛芬克(ethiofencarb)、愛殺松(ethion)、普伏松(ethoprophos)、胺磺磷(famphur)、芬滅松(fenamiphos)、撲滅松(fenitrothion)、丁基滅必蝨(fenobucarb)、芬殺松(fenthion)、覆滅蟎(formetanate)、福賽絕(fosthiazate)、呋線威(furathiocarb)、飛達松(heptenophos)、新煙鹼類(imicyafos)、亞芬松(isofenphos)、滅必蝨(isoprocarb)、異丙基 O-(甲氧基胺基硫基-磷醯基)水楊酸酯、加褔松(isoxathion)、馬拉松(malathion)、滅加松(mecarbam)、達馬松(methamidophos)、滅大松(methidathion)、滅賜克(methiocarb)、納乃得(methomyl)、治滅蝨(metolcarb)、美文松(mevinphos)、亞素靈(monocrotophos)、乃力松(Naled)、歐滅松(omethoate)、歐殺滅(oxamyl)、滅多松(oxydemeton-methyl)、巴拉松(parathion)、甲基巴拉松、賽達松(phenthoate)、福瑞松(phorate)、裕必松(phosalone)、益滅松(phosmet)、福賜米松(phosphamidon)、巴賽松(phoxim)、比加普(pirimicarb)、亞特松(pirimiphos-methyl)、佈飛松(profenofos)、撲達松(propetamphos)、安丹(propoxur)、普硫松(prothiofos)、白克松(pyraclofos)、必芬松(pyridaphenthion)、拜裕松(quinalphos)、治螟磷(sulfotep)、丁基嘧啶磷(tebupirimfos)、亞培松(temephos)、托福松(terbufos)、樂本松(tetrachlorvinphos)、硫敵克(thiodicarb)、硫伐隆(thiofanox)、硫滅松(thiometon)、唑蚜威(triazamate)、三落松(triazophos)、三氯松(trichlorfon)、混滅威(trimethacarb)、繁米松(vamidothion)、XMC，以及滅爾蝨(xylylcarb)。(2) GABA- 閘控型氯離子通道拮抗劑 ，包括下列活性成分：可氯丹(chlordane)、安殺番(endosulfan)、乙蟲腈(ethiprole)，以及芬普尼(fipronil)。(3) 鈉離子通道調節劑 ，包括下列活性成分：阿納寧(acrinathrin)、亞列寧(allethrin)、右旋 - 順式- 反式 氯丙炔菊酯(d–cis–trans allethrin)、右旋反式 氯丙炔菊酯(d-trans -allethrin)、畢芬寧(bifenthrin)、百亞列寧(bioallethrin)、S–環戊烯基百亞列寧 (bioallethrin S–cyclopentenyl)、生物苄呋菊酯(bioresmethrin)、乙氰菊酯(cycloprothrin)、賽扶寧(cyfluthrin)、β-賽扶寧、賽洛寧(cyhalothrin)、λ-賽洛寧(lambda- cyhalothrin)、γ-賽洛寧、賽滅寧(cypermethrin)、α-賽滅寧、β-賽滅寧、θ-賽滅寧、ζ-賽滅寧、賽酚寧[(1R)– 反式 –異構物] (cyphenothrin [(1R)–trans –isomers])、第滅寧(deltamethrin)、益避寧[(EZ )–(1R )–異構物] (empenthrin[(EZ )–(1R )–isomers])、益化利(esfenvalerate)、依芬寧(etofenprox)、芬普寧(fenpropathrin)、芬化利(fenvalerate)、護賽寧(flucythrinate)、氟氯苯菊酯(flumethrin)、τ-福化利(tau -fluvalinate)、合芬寧(halfenprox)、依普寧(imiprothrin)、噻嗯菊酯(kadethrin)、百滅寧(permethrin)、酚丁滅寧[(1R)– 反式 –異構物] (phenothrin [(1R)–trans –isomer])、普亞烈寧(prallethrin)、除蟲菊精(除蟲菊酯(pyrethrum))、吡菊酯(pyresmethrin)、矽護芬(silafluofen)、汰福寧(tefluthrin)、治滅寧(tetramethrin)、治滅寧[(1R )–異構物]、泰滅寧(tralomethrin)，以及甲氧滴滴涕(methoxychlor)。(4) 菸 鹼型乙醯膽鹼(nAChR) 協同劑 ，包括下列活性成分：(4A) 亞滅培(acetamiprid)、可尼丁(clothianidin)、達特南(dinotefuran)、益達胺(imidacloprid)、烯啶蟲胺(nitenpyram)、賽果培(thiacloprid)、賽速安(thiamethoxam)，(4B) 尼古丁，(4C) 氟啶蟲胺腈(sulfoxaflor)，(4D) 弗比南載夫隆(flupyradifurone)，(4E) 三福滅作派林(triflumezopyrim)及二氯滅座替(dicloromezotiaz)。(5) 菸 鹼型乙醯膽鹼受器(nAChR) 別構活化物 ，包括下列活性成分：賜諾特(spinetoram)及賜諾殺(spinosad)。(6) 氯離子通道活化劑 ，包括下列活性成分：阿巴美丁(abamectin)、因滅汀苯甲酸鹽(emamectin benzoate)、里琵菌素(lepimectin)，以及密滅汀(milbemectin)。(7) 保幼激素模擬物 ，包括下列活性成分：烯蟲乙酯(hydroprene)、烯蟲炔酯(kinoprene)、美賜平(methoprene)、芬諾克(fenoxycarb)，以及百利普芬(pyriproxyfen)。(8) 雜類非特異性( 多重位置) 抑制劑 ，包括下列活性成分：溴甲烷、氯化苦(chloropicrin)、磺醯氟、硼砂、硼酸、八硼酸二鈉、硼酸鈉、偏硼酸鈉、吐酒石、重氮甲(diazomet)，以及斯美地(metam)。(9) 弦音器官 (Chordotonal Organs ) 調節劑 ，包括下列活性成分：派滅淨(pymetrozine)及氟尼胺(flonicamid)。(10) 蟎生長抑制劑 ，包括下列活性成分：克芬蟎(clofentezine)、合賽多(hexythiazox)、氟蟎(diflovidazin)，以及依殺蟎(etoxazole)。(11) 破壞昆蟲中腸膜之微生物 ，包括下列活性成分：蘇力菌以色列亞種(Bacillus thuringiensis subsp. israelensis )、蘇力菌鮎澤亞種(Bacillus thuringiensis subsp. aizawai )、蘇力菌庫斯克亞種(Bacillus thuringiensis subsp. kurstaki )、蘇力菌擬步行甲亞種(Bacillus thuringiensis subsp. tenebrionenis )、Bt作物蛋白(Bt crop proteins) (Cry1Ab、Cry1Ac、Cry1Fa、Cry1A.105、Cry2Ab、Vip3A、mCry3A、Cry3Ab、Cry3Bb、Cry34Ab1/Cry35Ab1)，以及球形芽孢桿菌(Bacillus sphaericus )。(12) 粒腺體ATP 合成酶抑制劑 ，包括下列活性成分：得脫蟎(tetradifon)、毆蟎多(propargite)、亞環錫(azocyclotin)、錫蟎丹(cyhexatin)、芬佈賜(fenbutatin oxide)，以及汰芬隆(diafenthiuron)。(13) 經由破壞質子梯度之氧化性磷酸化非耦聯劑 ，包括下列活性成分：克凡派(chlorfenapyr)、DNOC，以及氟蟲胺(sulfluramid)。(14) 菸 鹼型乙醯膽鹼受器(nAChR) 通道阻斷劑 ，包括下列活性成分：免速達(bensultap)、培丹鹽酸鹽(cartap hydrochloride)、硫賜安(thiocyclam)，以及殺蟲雙鈉(thiosultap–sodium)。(15) 幾丁質生合成抑制劑，第0 型 ，包括下列活性成分：雙三氟蟲脲(bistrifluron)、克福隆(chlorfluazuron)、二福隆(diflubenzuron)、氟蟎脲(flucycloxuron)、氟芬隆(flufenoxuron)、六伏隆(hexaflumuron)、祿芬隆(lufenuron)、諾伐隆(novaluron)、多氟脲(noviflumuron)、得福隆(teflubenzuron)，以及三福隆(triflumuron)。(16) 幾丁質生合成抑制劑，第1 型 ，包括下列活性成分：布芬淨(buprofezin)。(17) 雙翅目脫皮干擾劑 ，包括下列活性成分：賽滅淨(cyromazine)。(18) 蛻皮激素受器協同劑 ，包括下列活性成分：可芬諾(chromafenozide)、合芬隆(halofenozide)、滅芬諾(methoxyfenozide)，以及得芬諾(tebufenozide)。(19) 章魚胺受器協同劑 ，包括下列活性成分：三亞蟎(amitraz)。(20) 粒腺體複合物III 電子傳遞抑制劑 ，包括下列活性成分：愛美隆(hydramethylnon)、亞醌蟎(acequinocyl)，以及嘧蟎酯(fluacrypyrim)。(21) 粒腺體複合物I 電子傳遞抑制劑 ，包括下列活性成分：芬殺蟎(fenazaquin)、芬普蟎(fenpyroximate)、畢汰芬(pyrimidifen)、畢達本(pyridaben)、得芬瑞(tebufenpyrad)、脫芬瑞(tolfenpyrad)，以及魚藤酮(rotenone)。(22) 電壓- 依賴型鈉離子通道阻斷劑 ，包括下列活性成分：因得克(indoxacarb)以及美氟綜(metaflumizone)。(23) 乙醯基輔酶A 羧化酶抑制劑 ，包括下列活性成分：賜派芬(spirodiclofen)、螺甲蟎酯(spiromesifen)，以及螺蟲乙酯(spirotetramat)。(24) 粒腺體複合物IV 電子傳遞抑制劑 ，包括下列活性成分：磷化鋁、磷化鈣、膦、磷化鋅，以及氰化物。(25) 粒腺體複合物II 電子傳遞抑制劑 ，包括下列活性成分：唑蟎氰(cyenopyrafen)、賽芬蟎(cyflumetofen)，及派福布敏(pyflubumide)，以及(28) 羅納丹受 器 (R yanodine receptor) 調節劑 ，包括下列活性成分：剋安勃(chlorantraniliprole)、氰蟲醯胺(cyantraniliprole)，以及氟大滅(flubendiamide)。The term " MoA material " means an active ingredient having the mode of action (" MoA ") as shown in irac-online.org., IRAC MoA Classification v. 7.4, describing the following groups. (1) Acetylcholinesterase (AChE) inhibitors , including the following active ingredients: acephate, alanycarb, aldicarb, azamethiphos, ethyl valley Azinphos-ethyl, azinphos-methyl, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, cadusafos ), carbaryl, carbofuran, carbosulfan, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos, Chlorpyrifos-methyl, coumaphos, cyanophos, methyl endophos-S, diazinon, dichlorvos/DDVP, bistroxine Dicrotophos), dimethoate, dimethylvinphos, disulfoton, EPN, ethiofencarb, ethion, ethoprophos, Famphur, fenamiphos, fenitrothion, fenobucarb, fenthion, Eta form (formetanate), fosthiazate, furathiocarb, heptenophos, imicyafos, isofenphos, isoprocarb, iso Propyl O-(methoxyaminothio-phosphonium) salicylate, isoxathion, malathion, mecarbam, methamidophos, dexamethasone (methidathion), metiocarb, methomyl, metolcarb, mevinphos, monocrotophos, Naled, omethoate ), oxamyl, oxydemeton-methyl, parathion, methyl balason, phenthoate, phorate, phosalone, Phosmet, phosphamidon, phoxim, pirimicarb, pirimiphos-methyl, profenofos, propetamphos, Propoxur, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, butyl Tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiodicarb, thiofanox, thiometon, oxazolide (triazamate), triazophos, trichlorfon, trimethacarb, vamidothion, XMC, and xylylcarb. (2) GABA-thyristing chloride channel antagonists , including the following active ingredients: chlordane, endosulfan, ethiprole, and fipronil. (3) sodium channel modulators, comprising the following active ingredients: Ana Ning (acrinathrin), Ya Liening (allethrin), dextrose - cis - trans-chloropropyl prallethrin (d-cis-trans allethrin) , dextrorotatory trans-chloropropyl prallethrin (d-trans -allethrin), Bifen Ning (bifenthrin), one hundred Ya Liening (bioallethrin), S- cyclopentenyl one hundred Ya Liening (bioallethrin S-cyclopentenyl), bioresmethrin (bioresmethrin ), B cyhalothrin (cycloprothrin), SIFE Ning (cy fl uthrin), β- SIFE Ning, xeronine (cyhalothrin), λ- xeronine (lambda- cyhalothrin), γ- xeronine, race deltamethrin (cypermethrin), α-赛灭宁, β-赛灭宁, θ-赛灭宁, ζ-赛灭宁, 赛素宁 [(1 R) -trans- isomer] (cyphenothrin [(1 R ) -trans -isomers]), deltamethrin (deltamethrin), beneficial to avoid Ning [(EZ) - (1 R ) - isomer] (empenthrin [(EZ) - (1 R) -isomers]), the benefits of Esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, tau- fluvalinate ), Hefen (halfenprox), according Puning (imiprothrin), thiophene ah permethrin (kadethrin), permethrin (permethrin), phenol Ding Miening [(1 R) - trans - isomer] (phenothrin [(1 R) - Trans- isomer]), prallethrin, pyrethrin (pyrethrum), pyrethyrrin, silafluofen, tefluthrin, Terpene (tetramethrin), sputum [(1 R )-isomer], tramomethrin, and methoxychlor. (4) type nicotinic acetylcholine (the nAChR) synergists, comprising the following active ingredients: (. 4A) alkylene off culture (, acetamiprid), clothianidin (, clothianidin), Date Nan (dinotefuran), benefits of the amine (of imidacloprid ), nitenpyram, thiacloprid, thiamethoxam, (4B) nicotine, (4C) fluramide, (4D) Verbinan (flupyradifurone), (4E) Triflumezopyrim and dicloromezotiaz. (5) type nicotinic acetylcholine receptors (the nAChR) allosteric activator, comprising the following active ingredients: Knott give (spinetoram,) and spinosad (spinosad). (6) Chloride channel activators , including the following active ingredients: abamectin, emamectin benzoate, lepimectin, and milbemectin. (7) Juvenile hormone mimics , including the following active ingredients: hydroprene, kinoprene, metoprene, fenoxycarb, and bailipfen ( Pyriproxyfen). (8) Heterogeneous non-specific ( multi-site) inhibitors , including the following active ingredients: methyl bromide, chloropicrin, sulfonium fluoride, borax, boric acid, disodium octaborate, sodium borate, sodium metaborate, spit Tartar, diazomet, and metam. (9) open string organs (Chordotonal Organs) modulators, comprising the following active ingredients: send off the net (pymetrozine) and niflumic amine (flonicamid). (10) 螨 growth inhibitors , including the following active ingredients: clefentezine, hexythiazox, fluoroquinone (diflovidazin), and by etoxazole. (11) Microorganisms that destroy the intestinal membrane of insects , including the following active components: Bacillus thuringiensis subsp. israelensis , Bacillus thuringiensis subsp. aizawai , Suricus cusia ( Bacillus thuringiensis subsp. kurstaki ), Bacillus thuringiensis subsp. tenebrionenis , Bt crop proteins (Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1/Cry35Ab1), and Bacillus sphaericus . (12) Granular gland ATP synthase inhibitors , including the following active ingredients: tetradifon, propargite, azocyclotin, cyhexatin, fenbutatin Oxide), and diafenthiuron. (13) An oxidative phosphorylation non-coupling agent that destroys a proton gradient , including the following active ingredients: chlorfenapyr, DNOC, and sulfluramid. (14) type nicotinic acetylcholine receptors (the nAChR) channel blockers, including the following active ingredients: Free Speed up (bensultap), Peidan hydrochloride (cartap hydrochloride), thanks Ann sulfur (, thiocyclam,), and kill Sodium thiosultap-sodium. (15) Chitin biosynthesis inhibitor, type 0 , including the following active ingredients: bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufen Flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, and triflumuron. (16) Chitinogenic synthesis inhibitor, type 1 , including the following active ingredient: buprofezin. (17) Diptera peeling interferer , including the following active ingredients: cyromazine. (18) A ecdysone receptor synergist comprising the following active ingredients: chromafenozide, halofenozide, methoxyfenozide, and tebufenozide. (19) Octopamine receptor synergist comprising the following active ingredient: amitraz. (20) Granular gland complex III electron transport inhibitor , comprising the following active ingredients: hydramethylnon, acequinocyl, and fluacrypyrim. (21) Granular gland complex I electron transport inhibitors , including the following active ingredients: fenazaquin, fenpyroximate, pyrimidifen, pyridaben, defenyl (tebufenpyrad), tolfenpyrad, and rotenone. (22) Voltage- dependent sodium channel blockers , including the following active ingredients: indoxacarb and metaflumizone. (23) Acetylpyrase A carboxylase inhibitor , comprising the following active ingredients: spirodiclofen, spiromesifen, and spirotetramat. (24) Granular gland complex IV electron transport inhibitor comprising the following active ingredients: aluminum phosphide, calcium phosphide, phosphine, zinc phosphide, and cyanide. (25) mitochondrial complex II electron transport inhibitors comprises the following active ingredients: cyanomethyl oxazole mite (cyenopyrafen), Saifun mite (Cyflumetofen and), and send Fubu Min (pyflubumide), and (28) by Luona Dan is (R yanodine receptor) modulators, comprising the following active ingredients: Kean Bo (chlorantraniliprole), cyano insect Amides (cyantraniliprole), and large-fluoro-off (flubendiamide).

這個版本的分類系統未分配第26組及第27組。此外，有包含未知的或是不確定的作用模式之活性成分UN 組 。此組包括下列活性成分：印苦楝子素(azadirachtin)、西脫蟎(benzoximate)、必芬蟎(bifenazate)、新殺蟎(bromopropylate)、蟎離丹(chinomethionat)、冰晶石(cryolite)、大克蟎(dicofol)、啶蟲丙醚(pyridalyl)，以及氟蟲吡喹(pyrifluquinazon)。This version of the classification system is not assigned Groups 26 and 27. In addition, there are active ingredient groups of UN containing unknown or indeterminate modes of action. This group includes the following active ingredients: azadirachtin, benzoximate, bifenazate, bromopropylate, chinomethionat, cryolite, large Dicofol, pyridalyl, and pyrifluquinazon.

術語「害蟲 」係意指一種生物體，其對人類或是人類關心的事物(譬如，作物、食物、家畜等等)是有害的，該生物體係來自於節肢動物門、軟體動物門，或圓形動物門。特定的實例為螞蟻、蚜蟲、床虱(bed bug)、甲蟲、蠹蟲(bristletails)、毛蟲、蟑螂、蟋蟀、蠼螋(earwigs)、跳蚤、蒼蠅、蚱蜢、螬、大黃蜂、小葉蟬(jassids)、葉蟬、蝨、蝗蟲、蛆、水蠟蟲(mealybugs)、蟎、蛾、線蟲(nematode)、盲蝽(plantbug)、飛蝨(planthopper)、木蝨(psyllids)、鋸蜂(sawflies)、介殼蟲、蠹魚(silverfish)、蛞蝓、蝸牛、蜘蛛、彈尾蟲、臭蟲、綜合綱(symphylans)、白蟻、薊馬(thrips)、壁蝨、胡蜂、粉虱，以及線蟲(wireworm)。The term " pest " means an organism that is harmful to humans or things that humans care about (such as crops, food, livestock, etc.) from arthropods, mollusks, or circles. Shaped animal door. Specific examples are ants, mites, bed bugs, beetles, bristletails, caterpillars, crickets, crickets, earwigs, fleas, flies, crickets, crickets, bumblebees, jassids. , leafhoppers, crickets, locusts, crickets, melybugs, crickets, moths, nematodes, plantbugs, planthoppers, psyllids, sawflies, Scale insects, silverfish, snails, snails, spiders, snails, bed bugs, symphylans, termites, thrips, ticks, wasps, whiteflies, and wireworms.

額外的實例為下列之害蟲：(1) 螯肢動物亞門(Subphyla Chelicerata) 、多足亞門(Myriapoda) ，及六足亞門(Hexapoda) 。(2) 蛛形綱 (Arachnida) 、綜合綱 (Symphyla) ， 及昆蟲綱 (Insecta) 。 (3) 虱目 (Order Anoplura) 。特定屬之非窮舉性清單包括，但不限於，血虱屬(Haematopinus spp.)、甲脅虱屬(Hoplopleura spp.)、顎虱屬(Linognathus spp.)、虱屬(Pediculus spp.)、鱗虱屬(Polyplax spp.)、牛蝨屬(Solenopotes spp.)及新血虱屬(Neohaematopinis spp.)。特定物種之非窮舉性清單包括，但不限於，驢血虱(Haematopinus asini )、豬血虱(Haematopinus suis )、毛虱(Linognathus setosus )、綿羊顎虱(Linognathus ovillus )、人頭蝨(Pediculus humanus capitis )、人體虱(Pediculus humanus humanus )及陰虱(Pthirus pubis )。(4) 鞘翅目 (Order Coleoptera) 。特定屬之非窮舉性清單包括但不限於，豆象屬(Acanthoscelides spp.)、叩頭蟲屬(Agriotes spp.)、花象屬(Anthonomus spp.)、梨象屬(Apion spp.)、金龜屬(Apogonia spp.)、(Araecerus spp.)、守瓜屬(Aulacophora spp.)、豆象蟲屬(Bruchus spp.)、天牛屬(Cerosterna spp.)、豆葉甲蟲屬(Cerotoma spp.)、龜象屬(Ceutorhynchus spp.)、跳甲屬(Chaetocnema spp.)、肖葉甲蟲屬(Colaspis spp.)、金針蟲屬(Ctenicera spp.)、象鼻蟲屬(Curculio spp.)、圓頭犀金龜屬(Cyclocephala spp.)、葉甲屬(Diabrotica spp.)、竹長蠹屬(Dinoderus spp.)、榖盜屬(Gnathocerus spp.)、竊蠹屬(Hemicoelus spp.)、異翅長蠹屬(Heterobostruchus spp.)、葉象屬(Hypera spp.)、齒小蠹屬(Ips spp.)、粉蠹屬(Lyctus spp.)、美洲葉甲屬(Megascelis spp.)、露尾甲屬(Meligethes spp.)、蜘蛛甲屬(Mezium spp.)、褐蛛甲屬(Niptus spp.)、耳象屬屬(Otiorhynchus spp.)、短喙象屬(Pantomorus spp.)、鰓角金龜屬(Phyllophaga spp.)、菜葉蚤屬(Phyllotreta spp.)、蛛甲屬(Ptinus spp.)、根觸金龜屬(Rhizotrogus spp.)、虎象屬(Rhynchites spp.)、大象鼻蟲屬(Rhynchophorus spp.)、小蠹屬(Scolytus spp.)、禾象鼻蟲屬(Sphenophorus spp.)、米象屬(Sitophilus spp.)、擬步行蟲屬(Tenebrio spp.)，以及擬穀盜屬(Tribolium spp.)。特定物種之非窮舉性清單包括但不限於，菜豆象(Acanthoscelides obtectus )、白蠟窄吉丁(Agrilus planipennis )、背圓粉扁蟲(Ahasverus advena )、外米擬步行蟲(Alphitobius diaperinus )、光肩星天牛(Anoplophora glabripennis )、棉鈴象蟲(Anthonomus grandis )、小園皮蠹(Anthrenus verbasci )、麗黃圓皮蠹(Anthrenus falvipes )、黑絨金龜(Ataenius spretulus )、甜菜隱食甲蟲(Atomaria linearis )、黑毛皮蠹(Attagenus unicolor )、甜菜象(Bothynoderes punctiventris )、豌豆象(Bruchus pisorum )、四紋豆象(Callosobruchus maculatus )、黃斑露尾甲(Carpophilus hemipterus )、甜菜龜甲(Cassida vittata )、方頸扁甲(Cathartus quadricollis )、豆葉甲(Cerotoma trifurcata )、白菜籽龜象(Ceutorhynchus assimilis )、芫菁龜象(Ceutorhynchus napi )、梯斑叩頭蟲(Conoderus scalaris )、多斑叩頭蟲(Conoderus stigmosus )、李象鼻蟲(Conotrachelus nenuphar )、綠花金龜(Cotinis nitida )、天門冬金花蟲(Crioceris asparagi )、鏽赤扁穀盜(Cryptolestes ferrugineus )、長角扁穀盜(Cryptolestes pusillus )、土耳其扁穀盜(Cryptolestes turcicus )、密點細枝象蟲(Cylindrocopturus adspersus )、芒果切葉象甲(Deporaus marginatus )、火腿皮蠹(Dermestes lardarius )、白腹皮蠹(Dermestes maculatus )、墨西哥豆瓢蟲(Epilachna varivestis )、盾葉蟲(Euvrilletta peltata )、蛀莖象甲(Faustinus cubae )、蒼白根頸象(Hylobius pales )、家天牛(Hylotrupes bajulus )、紫苜蓿葉象(Hypera postica )、咖啡果小蠹(Hypothenemus hampei )、菸草甲(Lasioderma serricorne )、馬鈴薯甲蟲(Leptinotarsa decemlineata )、太平洋岸線蟲(Limonius canus )、麗金龜(Liogenys fuscus )、條紋水象甲(Liogenys suturalis )、水稻水象鼻蟲(Lissorhoptrus oryzophilus )、暹羅榖盜(Lophocateres pusillus )、平頸粉蠹(Lyctus planicollis)、Maecolaspis joliveti 、玉米叩甲(Melanotus communis )、油菜露尾甲(Meligethes aeneus )、大栗鰓角金龜子(Melolontha melolontha )、赤足郭公蟲(Necrobia rufipes )、梯頂天牛(Oberea brevis )、線形筒天牛(Oberea linearis )、椰子犀角金龜(Oryctes rhinoceros )、貿易穀盜扁蟲(Oryzaephilus mercator )、鋸穀盜(Oryzaephilus surinamensis )、黑角負泥蟲(Oulema melanopus )、水稻負泥蟲(Oulema oryzae )、金龜子(Phyllophaga cuyabana )、黑粉蠹蟲(Polycaon stoutti )、日本麗金龜(Popillia japonica )、大穀蠹(Prostephanus truncatus )、穀蠹(Rhyzopertha dominica )、條紋根瘤象甲(Sitona lineatus )、穀象(Sitophilus granarius )、米象(Sitophilus oryzae )、玉米象(Sitophilus zeamais )、藥材甲(Stegobium paniceum )、大榖盜(Tenebroides mauritanicus )、擬穀盜(Tribolium castaneum )、雜擬穀盜(Tribolium confusum )、小紅鰹節蟲(Trogoderma granarium )、花斑皮蠹(Trogoderma variabile )、紅毛竊蠹(Xestobium rufovillosum )，及玉米距步甲蟲(Zabrus tenebrioides )。(5) 革翅目 (Order Dermaptera) 。特定屬之非窮舉性清單包括但不限於，普通蠼螋(Forficula auricularia )。(6) 蜚蠊目 (Order Blattaria) 。特定物種之非窮舉性清單包括但不限於，德國姬蠊(Blattella germanica )、亞洲姬蠊(Blattella asahina )、東方蜚蠊(Blatta orientalis )、櫻桃紅蟑螂(Blatta lateralis )、賓西法尼亞木蠊(Parcoblatta pennsylvanica )、美洲家蠊(Periplaneta americana )、澳洲家蠊(Periplaneta australasiae )、棕色家蠊(Periplaneta brunnea )、黑褐家蠊(Periplaneta fuliginosa )、蔗綠蜚蠊(Pycnoscelus surinamensis )及長鬚帶蠊(Supella longipalpa )。(7) 雙翅目 (Order Diptera) 。特定屬之非窮舉性清單包括但不限於，斑蚊屬(Aedes spp.)、潛蠅屬(Agromyza spp.)、按實蠅屬(Anastrepha spp.)、瘧蚊屬(Anopheles spp.)、果實蠅屬(Bactrocera spp.)、地中海實蠅屬(Ceratitis spp.)、斑虻屬(Chrysops spp.)、錐蠅屬(Cochliomyia spp.)、癭蚊屬(Contarinia spp.)、家蚊屬(Culex spp.)、庫蠓屬(Culicoides spp.)、葉癭蚊屬(Dasineura spp.)、艷粉蝶屬(Delia spp.)、果蠅屬(Drosophila spp.)、廁蠅屬(Fannia spp.)、黑蠅屬(Hylemya Hylemyia spp.)、斑潛蠅屬(Liriomyza spp.)、家蠅屬(Musca spp.)、草種蠅屬(Phorbia spp.)、粉蠅屬(Pollenia spp.)、蛾蚋屬(Psychoda spp.)、蚋屬(Simulium spp.)、虻屬(Tabanus spp.)及大蚊屬(Tipula spp.)。特定物種之非窮舉性清單包括但不限於，紫苜蓿潛蠅(Agromyza frontella )、加勒比按實蠅(Anastrepha suspensa )、墨西哥果實蠅(Anastrepha ludens )、西印度果實蠅(Anastrepha obliqua)、瓜實蠅(Bactrocera cucurbitae )、東方果實蠅(Bactrocera dorsalis )、入侵實蠅(Bactrocera invadens )、桃實蠅(Bactrocera zonata )、地中海實蠅(Ceratitis capitata )、油菜葉癭蚊(Dasineura brassicae )、灰地種蠅(Delia platura )、黃腹廁蠅(Fannia canicularis )、灰腹廁蠅(Fannia scalaris )、腸胃蠅(Gasterophilus intestinalis )、Gracillia perseae 、東方臂蠅(Haematobia irritans )、紋皮蠅(Hypoderma lineatum )、菜斑潛蠅(Liriomyza brassicae )、蔬菜斑潛蠅(Liriomyza sativa )、綿羊虱蠅(Melophagus ovinus )、秋家蠅(Musca autumnalis )、普通家蠅(Musca domestica )、羊狂蠅(Oestrus ovis )、黑麥稈蠅(Oscinella frit )、甜菜泉蠅(Pegomya betae )、鎧氏酪蠅(Piophila casei )、胡蘿蔔蠅(Psila rosae )、櫻桃果實蠅(Rhagoletis cerasi )、蘋果果實蠅(Rhagoletis pomonella )、藍橘繞實蠅(Rhagoletis mendax )、麥紅吸漿蟲(Sitodiplosis mosellana )及廄螫蠅(Stomoxys calcitrans )。(8) 半翅目 (Order Hemiptera) 。特定屬之非窮舉性清單包括但不限於，球蚜屬(Adelges spp.)、輪盾介殼蟲屬(Aulacaspis spp.)、沫蟬屬(Aphrophora spp.)、蚜蟲屬(Aphis spp.)、粉虱屬(Bemisia spp.)、蠟蚧屬(Ceroplastes spp.)、雪盾介殼蟲屬(Chionaspis spp.)、褐圓盾介殼蟲屬(Chrysomphalus spp.)、介殼蟲屬(Coccus spp.)、小綠葉蟬屬(Empoasca spp.)、美洲蝽屬(Euschistus spp.)、蠣盾介殼蟲屬(Lepidosaphes spp.)、稻椿象屬(Lagynotomus spp.)、草盲蝽屬(Lygus spp.)、長管蚜屬(Macrosiphum spp.)、黑尾葉蟬屬(Nephotettix spp.)、稻綠蝽屬(Nezara spp.)、褐飛蝨屬(Nilaparvata spp.)、沫蟬屬(Philaenus spp.)、植盲蝽屬(Phytocoris spp.)、壁蝽屬(Piezodorus spp.)、臀紋粉介殼蟲屬(Planococcus spp.)、粉介殼蟲屬(Pseudococcus spp.)、縊管蚜屬(Rhopalosiphum spp.)、黑盔蚧屬(Saissetia spp.)、彩斑蚜屬(Therioaphis spp.)、蠟蚧蟲屬(Toumeyella spp.)、桔蚜屬(Toxoptera spp.)、粉虱屬(Trialeurodes spp.)、錐蝽屬(Triatoma spp.)及矢盾介殼蟲屬(Unaspis spp.)。特定物種之非窮舉性清單包括但不限於，擬綠蝽(Acrosternum hilare )、豌豆蚜(Acyrthosiphon pisum )、甘藍粉虱(Aleyrodes proletella )、螺旋粉虱(Aleurodicus dispersus )、絲絨粉虱(Aleurothrixus floccosus )、二點小綠葉蟬(Amrasca biguttula biguttula )、紅圓蚧(Aonidiella aurantii )、蠶豆蚜(Aphis fabae )、棉蚜(Aphis gossypii )、大豆蚜(Aphis glycines )、蘋果蚜(Aphis pomi )、馬鈴薯蚜(Aulacorthum solani )、馬鈴薯/番茄木虱(Bactericera cockerelli )、黃星菘蝽(Bagrada hilaris )、銀葉粉虱(Bemisia argentifolii )、煙草粉虱(Bemisia tabaci )、麥長蝽(Blissus leucopterus )、梣葉槭蝽(Boisea trivittata )、天門冬小管蚜(Brachycorynella asparagi )、稻粉介殼蟲(Brevennia rehi )、甘藍蚜(Brevicoryne brassicae )、梨木蝨(Cacopsylla pyri )、梨黃木蝨(Cacopsylla pyricola )、馬鈴薯俊盲蝽(Calocoris norvegicus )、紅蠟介殼蟲(Ceroplastes rubens )、熱帶臭蟲(Cimex hemipterus )、溫帶臭蟲(Cimex lectularius )、桔軟蠟介殼蟲(Coccus pseudomagnoliarum )、Dagbertus fasciatus 、Dichelops furcatus 、麥雙尾蚜(Diuraphis noxia )、柑橘木虱(Diaphorina citri )、車前圓尾蚜(Dysaphis plantaginea )、棉黑翅紅蝽(Dysdercus suturellus )、Edessa meditabunda 、假眼小綠葉蟬(Empoasca vitis )、蘋果綿蚜(Eriosoma lanigerum )、西方葡萄葉蟬(Erythroneura elegantula )、歐扁盾蝽(Eurygaster maura )、美洲蝽(Euschistus conspersus )、英雄美洲蝽(Euschistus heros )、褐美洲蝽(Euschistus servus )、褐翅蝽(Halyomorpha halys )、安氏角盲蝽(Helopeltis antonii )、桃粉蚜(Hyalopterus pruni )、安氏角盲蝽(Helopeltis antonii )、茶角盲蝽(Helopeltis theivora )、吹棉介殼蟲(Icerya purchasi )、檬果褐葉蟬(Idioscopus nitidulus )、小綠葉蟬(Jacobiasca formosana )、斑飛虱(Laodelphax striatellus )、東方球蠟蚧(Lecanium corni )、大稻緣蝽(Leptocorisa oratorius )、稻緣椿象(Leptocorisa varicornis )、豆莢草盲蝽(Lygus hesperus )、桑粉介殼蟲(Maconellicoccus hirsutus )、大戟長管蚜(Macrosiphum euphorbiae )、麥長管蚜(Macrosiphum granarium )、薔薇長管蚜(Macrosiphum rosae )、翠菊葉蟬(Macrosteles quadrilineatus )、沫蟬(Mahanarva frimbiolata )、豆龜蝽(Megacopta cribraria )、麥無網蚜(Metopolophium dirhodum )、長角蝽象(Mictis longicornis )、桃蚜(Myzus persicae )、萵苣蚜蟲(Nasonovia ribisnigri )、偽黑尾葉蟬(Nephotettix cincticeps )、Neurocolpus longirostris 、稻綠蝽(Nezara viridula )、褐飛蝨(Nilaparvata lugens )、木瓜秀粉介殼蟲(Paracoccus marginatus )、馬鈴薯/番茄木虱(Paratrioza cockerelli )、糠片盾蚧(Parlatoria pergandii )、黑片盾介殼蟲(Parlatoria ziziphi )、玉米花翅飛虱(Peregrinus maidis )、葡萄根瘤蚜(Phylloxera vitifoliae )、去杉球蚧(Physokermes piceae )、加州盲蝽(Phytocoris californicus )、植盲蝽(Phytocoris relativus )、蓋德擬壁蝽(Piezodorus guildinii )、桔臀紋粉介殼蟲(Planococcus citri )、無花果臀紋粉介殼蟲(Planococcus ficus )、四線盲蝽(Poecilocapsus lineatus )、盲蝽(Psallus vaccinicola )、酪梨椿象(Pseudacysta perseae )、菠蘿潔粉介殼蟲(Pseudococcus brevipes )、梨園盾蚧(Quadraspidiotus perniciosus )、玉米蚜(Rhopalosiphum maidis )、稻麥蚜(Rhopalosiphum padi )、欖珠蠟蚧(Saissetia oleae )、栗花椿象(Scaptocoris castanea )、麥二叉蚜(Schizaphis graminum )、麥長管蚜(Sitobion avenae )、白背飛虱(Sogatella furcifera )、溫室粉虱(Trialeurodes vaporariorum )、結翅粉蝨(Trialeurodes abutiloneus )、箭頭介殼蟲(Unaspis yanonensis )以及Zulia entrerriana 。(9) 膜翅目 (Order Hymenoptera) 。特定屬之非窮舉性清單包括但不限於，切葉蟻屬(Acromyrmex spp.)、葉蟻屬(Atta spp.)、巨山蟻屬(Camponotus spp.)、松葉蜂屬(Diprion spp.)、黃胡蜂屬(Dolichovespula spp.)、蟻屬(Formica spp.)、單家蟻屬(Monomorium spp.)、新松葉蜂屬(Neodiprion spp.)、黃山蟻屬(Paratrechina spp.)、大頭家蟻屬(Pheidole spp.)、收穫蟻屬(Pogonomyrmex spp.)、馬蜂屬(Polistes spp.)、紅火蟻屬(Solenopsis spp.)、扁琉璃蟻屬(Technomyrmex , spp.)、皺家蟻屬(Tetramorium spp.)、黃胡蜂屬(Vespula spp.)、胡蜂屬(Vespa spp.)，及絨木蜂屬(Xylocopa spp.)。特定物種之非窮舉性清單包括但不限於，紅角菜葉蜂(Athalia rosae )、德克塞斯切葉蟻(Atta texana )、櫻桃粘葉蜂(Caliroa cerasi )、美洲榆錘角葉蜂(Cimbex americana )、阿根廷虹琉璃蟻(Iridomyrmex humilis )、阿根廷蟻(Linepithema humile )、歐洲黑蜂(Mellifera Scutellata )、小黑蟻(Monomorium minimum )、小黃單家蟻(Monomorium pharaonis )、松黃葉蜂(Neodiprion sertifer )、入侵紅火蟻(Solenopsis invicta )、熱帶火蟻(Solenopsis geminata )、偷竊蟻(Solenopsis molesta )、黑火蟻(Solenopsis richtery )、南方火蟻(Solenopsis xyloni )、酸臭家蟻(Tapinoma sessile )，及小火蟻(Wasmannia auropunctata )。(10) 等翅目 (Order Isoptera) 。特定屬之非窮舉性清單包括但不限於，乳白蟻屬(Coptotermes spp.)、角象白蟻屬(Cornitermes spp.)、堆砂白蟻屬(Cryptotermes spp.)、異白蟻屬(Heterotermes spp.)、木白蟻屬(Kalotermes spp.)、楹白蟻屬(Incisitermes spp.)、大白蟻屬(Macrotermes spp.)、緣木白蟻屬(Marginitermes spp.)、鋸白蟻屬(Microcerotermes spp.)、原角白蟻屬(Procornitermes spp.)、散白蟻屬(Reticulitermes spp.)、長鼻白蟻屬(Schedorhinotermes spp.)及古白蟻屬(Zootermopsis spp.)。特定物種之非窮舉性清單包括但不限於，(Coptotermes acinaciformis )、曲顎乳白蟻(Coptotermes curvignathus )、法國乳白蟻(Coptotermes frenchii )、臺灣乳白蟻(Coptotermes formosanus )、格斯特乳白蟻(Coptotermes gestroi )、麻頭堆砂白蟻(Cryptotermes brevis )、金黃異白蟻(Heterotermes aureus )、南美異白蟻(Heterotermes tenuis )、小楹白蟻(Incisitermes minor )、斯氏楹白蟻(Incisitermes snyderi )、稻麥小白蟻(Microtermes obesi )、角象白蟻(Nasutitermes corniger )、臺灣土白蟻(Odontotermes formosanus )、土白蟻(Odontotermes obesus )、班努斯散白蟻(Reticulitermes banyulensis )、草地散白蟻(Reticulitermes grassei )、黃肢散白蟻(Reticulitermes flavipes )、哈氏散白蟻(Reticulitermes hageni )、西方散白蟻(Reticulitermes hesperus )、桑特散白蟻(Reticulitermes santonensis )、黃胸散白蟻(Reticulitermes speratus )、美黑脛散白蟻(Reticulitermes tibialis )及美小黑散白蟻(Reticulitermes virginicus )。(11) 鱗翅目 (Order Lepidoptera) 。特定屬之非窮舉性清單包括但不限於，捲葉蛾屬(Adoxophyes spp.)、地老虎屬(Agrotis spp.)、帶卷蛾屬(Argyrotaenia spp.)、卷葉蛾屬(Cacoecia spp.)、麗細蛾屬(Caloptilia spp.)、水稻螟蟲屬(Chilo spp.)、錁紋夜蛾屬(Chrysodeixis spp.)、豆粉蝶屬(Colias spp.)、草螟屬(Crambus spp.)、絹野螟屬(Diaphania spp.)、螟屬(Diatraea spp.)、鑽夜蛾屬(Earias spp.)、粉斑螟屬(Ephestia spp.)、尺蠖蛾屬(Epimecis spp.)、斑點夜蛾屬(Feltia spp.)、角劍夜蛾屬(Gortyna spp.)、鈴夜蛾屬(Helicoverpa spp.)、實夜蛾屬(Heliothis spp.)、根蠹屬(Indarbela spp. )、潛夜細蛾屬(Lithocolletis spp.)、切根蟲屬(Loxagrotis spp.)、天幕毛蟲屬(Malacosoma spp.)、谷蛾屬(Nemapogon spp.)、疆夜蛾屬(Peridroma spp.)、小潛細蛾屬(Phyllonorycter spp.)、黏夜蛾屬(Pseudaletia spp.)、菜蛾屬(Plutella spp.)、蛀莖夜蛾屬(Sesamia spp.)、夜盗蛾屬(Spodoptera spp.)、透翅蛾屬(Synanthedon spp.)及巢蛾屬(Yponomeuta spp.)。特定物種之非窮舉性清單包括但不限於，飛揚阿夜蛾(Achaea janata )、棉褐帶卷蛾(Adoxophyes orana )、小地老虎(Agrotis ipsilon )、棉葉波紋夜蛾(Alabama argillacea )、鱷梨卷葉蟲(Amorbia cuneana )、臍橙螟(Amyelois transitella )、棕灰蛾(Anacamptodes defectaria )、桃枒蛾(Anarsia lineatella )、黃麻夜蛾(Anomis sabulifera )、梨豆夜蛾(Anticarsia gemmatalis )、果樹黃捲蛾(Archips argyrospila )、玫瑰黃捲蛾(Archips rosana )、桔帶卷蛾(Argyrotaenia citrana )、伽馬紋夜蛾(Autographa gamma )、捲葉蛾(Bonagota cranaodes )、禾弄蝶(Borbo cinnara )、棉潛蛾(Bucculatrix thurberiella )、菸卷蛾(Capua reticulana )、桃蛀果蛾(Carposina niponensis )、芒果螟蛾(Chlumetia transversa )、玫瑰色卷蛾(Choristoneura rosaceana )、稻縱卷葉螟(Cnaphalocrocis medinalis )、可可細蛾(Conopomorpha cramerella )、外米綴蛾(Corcyra cephalonica )、芳香木蠹蛾(Cossus cossus )、石核桃卷蛾(Cydia caryana )、李小食心蟲(Cydia funebrana )、梨小食心蟲(Cydia molesta )、豌豆小卷蛾(Cydia nigricana )、蘋果蠹蛾(Cydia pomonella )、茶刺蛾(Darna diducta )、黄瓜絹野螟(Diaphania nitidalis )、小蔗桿草螟(Diatraea saccharalis )、西南玉米桿草螟(Diatraea graniosella )、埃及鑽夜蛾(Earias insulata )、翠紋鑽夜蛾(Earias vitella )、對小卷蛾(Ecdytolopha aurantianum )、南美玉米苗斑螟(Elasmopalpus lignosellus )、粉斑螟(Ephestia cautella )、菸草粉斑螟(Ephestia elutella )、地中海粉螟(Ephestia kuehniella )、大豆捲葉蛾(Epinotia aporema )、淡棕蘋果蛾(Epiphyas postvittana )、香蕉弄蝶(Erionota thrax )、鹽澤燈蛾(Estigmene acrea )、女貞細卷蛾(Eupoecilia ambiguella )、原切根蟲(Euxoa auxiliaris )、蠟螟(Galleria mellonella )、桃折心蟲(Grapholita molesta )、三紋螟蛾(Hedylepta indicata )、棉鈴蟲(Helicoverpa armigera )、玉米穗蟲(Helicoverpa zea )、菸芽夜蛾(Heliothis virescens )、菜心野螟(Hellula undalis )、番茄蠹蛾(Keiferia lycopersicella )、茄螟蛾(Leucinodes orbonalis )、咖啡潛葉蛾(Leucoptera coffeella )、旋紋潛蛾(Leucoptera malifoliella )、葡萄花翅小卷蛾(Lobesia botrana )、豆白緣切根蟲(Loxagrotis albicosta )、舞毒蛾(Lymantria dispar )、桃潛葉蛾(Lyonetia clerkella )、蓑蛾(Mahasena corbetti )、甘藍夜蛾(Mamestra brassicae )、烟草天蛾(Manduca sexta )、豆莢螟(Maruca testulalis )、袋蛾(Metisa plana )、栗夜盜蟲(Mythimna unipuncta )、番茄蛀蟲(Neoleucinodes elegantalis )、白水螟蛾(Nymphula depunctalis )、冬尺蠖蛾(Operophtera brumata )、歐洲玉米螟(Ostrinia nubilalis )、大戟草尺蠖蛾(Oxydia vesulia) 、疆褐卷蛾(Pandemis cerasana )、蘋褐卷蛾(Pandemis heparana )、非洲達摩鳳蝶(Papilio demodocus )、白咖啡潛夜蟲(Pectinophora gossypiella )、雜色夜蛾(Peridroma saucia )、咖啡潛葉蛾(Perileucoptera coffeella )、馬鈴薯蠹蛾(Phthorimaea operculella )、柑橘潛夜蛾(Phyllocnisitis citrella )、斑幕潛葉蛾(Phyllonorycter blancardella )、紋白蝶(Pieris rapae )、苜蓿綠夜蛾(Plathypena scabra )、蘋果芽小卷蛾(Platynota idaeusalis )、印度穀螟蛾(Plodia interpunctella )、小菜蛾(Plutella xylostella )、葡萄捲葉蛾(Polychrosis viteana )、桔果巢蛾(Prays endocarpa )、油橄欖巢蛾(Prays oleae )、一星黏蟲(Pseudaletia unipuncta )、大豆夜蛾(Pseudoplusia includens )、向日葵尺蠖(Rachiplusia nu )、三化螟(Scirpophaga incertulas )、稻蛀莖夜蛾(Sesamia inferens )、西非蛀莖夜蛾(Sesamia nonagrioides )、蕁麻毛蟲(Setora nitens )、麥蛾(Sitotroga cerealella )、葡萄長鬚卷葉蛾(Sparganothis pilleriana )、甜菜夜蛾(Spodoptera exigua )、草地貪夜蛾(Spodoptera fugiperda )、南部灰翅夜蛾(Spodoptera eridania )、菠蘿褐灰蝶(Thecla basilides )、衣蛾(Tinea pellionella )、袋衣蛾(Tineola bisselliella )、粉斑夜蛾(Trichoplusia ni )、番茄斑潛蠅(Tuta absoluta )、咖啡豹蠹蛾(Zeuzera coffeae )以及梨豹蠹蛾(Zeuzera pyrina )。(12) 食毛目 (Order Mallophaga) 。特定屬之非窮舉性清單包括但不限於，細鵝虱屬(Anaticola spp.)、牛毛虱屬(Bovicola spp.)、大火雞虱屬(Chelopistes spp.)、雞角羽虱(Goniodes spp.)、雞虱屬(Menacanthus spp.)及犬毛虱屬(Trichodectes spp.)。特定物種之非窮舉性清單包括但不限於，牛羽虱(Bovicola bovis )、山羊住牛虱(Bovicola caprae )、綿羊虱(Bovicola ovis )、大火雞虱(Chelopistes meleagridis )、雞角羽虱(Goniodes dissimilis )、大角羽虱(Goniodes gigas )、雛雞羽蝨(Menacanthus stramineus )、雞羽虱(Menopon gallinea )以及犬嚙毛虱(Trichodectes canis )。(13) 直翅目 (Order Orthoptera) 。特定屬之非窮舉性清單包括但不限於，黑蝗屬(Melanoplus spp.)及側羽葉屬(Pterophylla spp.)。特定物種之非窮舉性清單包括但不限於，家蟋蟀(Acheta domesticus )、摩門螽斯(Anabrus simplex )、非洲螻蛄(Gryllotalpa africana )、南方螻蛄(Gryllotalpa australis )、黑短螻蛄(Gryllotalpa brachyptera )、歐洲痣蟋蟀(Gryllotalpa hexadactyla )、東亞飛蝗(Locusta migratoria )、角翅螽斯(Microcentrum retinerve )、沙漠蝗(Schistocerca gregaria )，以及叉尾灌叢樹螽(Scudderia furcata )。(14) 囓蟲目 ( Order Psocoptera ) 。特定物種之非窮舉性清單包括但不限於，無色書蝨(Liposcelis decolor )、囓蟲書蝨(Liposcelis entomophila )、姬嚙蟲(Lachesilla quercus )，以及粉茶蛀蟲(Trogium pulsatorium )。(15) 蚤目 (Order Siphonaptera) 。特定物種之非窮舉性清單包括但不限於，雞角葉蚤(Ceratophyllus gallinae )、黑角葉蚤(Ceratophyllus niger )、犬櫛頭蚤(Ctenocephalides canis )、貓櫛頭蚤(Ctenocephalides felis )，以及人蚤(Pulex irritans )。(16) 纓翅目 (Order Thysanoptera) 。特定屬之非窮舉性清單包括但不限於，巢針薊馬屬(Caliothrips spp.)、花薊馬屬(Frankliniella spp.)、跳薊馬屬(Scirtothrips spp.)及薊馬屬(Thrips spp.)。特定物種之非窮舉性清單包括但不限於，巢針薊馬(Caliothrips phaseoli )、菱花薊馬(Frankliniella bispinosa )、菸褐花薊馬(Frankliniella fusca )、西方花薊馬(Frankliniella occidentalis )、梳缺花薊馬(Frankliniella schultzei )、檬果花薊馬(Frankliniella tritici )、威廉斯花薊馬(Frankliniella williamsi )、變葉木薊馬(Heliothrips haemorrhaidalis )、腹鉤薊馬(Rhipiphorothrips cruentatus )、桔硬薊馬(Scirtothrips citri )、小黃薊馬(Scirtothrips dorsalis )、帶薊馬(Taeniothrips rhopalantennalis )、黃胸薊馬(Thrips hawaiiensis )、豆黃薊馬(Thrips nigropilosus )、東方薊馬(Thrips orientalis )、南黃薊馬(Thrips palmi )，以及菸薊馬(Thrips tabaci )。(17) 纓尾目 (Order Thysanura) 。特定屬之非窮舉性清單包括但不限於，衣魚屬(Lepisma spp.)以及小灶衣魚屬(Thermobia spp.)。(18) 蜱蟎目 (Order Acarina) 。特定屬之非窮舉性清單包括但不限於，粉蟎屬(Acarus spp.)、刺皮節蜱屬(Aculops spp.)、Argus 屬(Argus spp.)、牛蜱蝨屬(Boophilus spp.)、蠕形蟎屬(Demodex spp.)、革蜱屬(Dermacentor spp.)、上癭蟎屬(Epitimerus spp.)、節蜱屬(Eriophyes spp.)、硬蜱屬(Ixodes spp.)、赤葉蟎屬(Oligonychus spp.)、全爪蟎屬(Panonychus spp.)、扇頭蜱屬(Rhizoglyphus spp.)及葉蟎屬(Tetranychus spp.)。特定物種之非窮舉性清單包括但不限於，伍德氏蟎(Acarapis woodi )、粗腳粉蟎(Acarus siro )、芒果瘤癭蟎(Aceria mangiferae )、番茄刺皮癭蟎(Aculops lycopersici )、皮氏刺皮癭蟎(Aculus pelekassi )、斯氏刺癭蟎(Aculus schlechtendali )、美洲鈍眼蜱(Amblyomma americanum )、卵形短鬚蟎(Brevipalpus obovatus )、紫紅短鬚蟎(Brevipalpus phoenicis )、變異革蜱(Dermacentor variabilis )、歐洲室塵蟎(Dermatophagoides pteronyssinus )、鵝耳櫪始葉蟎(Eotetranychus carpini )、異脂刺蟎(Liponyssoides sanguineus )、貓節痂蟎(Notoedres cati )、茶紅葉蟎(Oligonychus coffe a e )、伊氏赤葉蟎(Oligonychus ilicis )、柏氏禽刺蟎(Ornithonyssus bacoti )、柑橘葉蟎(Panonychus citri )、歐洲葉蟎(Panonychus ulmi )、柑桔皺葉刺節蜱(Phyllocoptruta oleivora )、側多食跗線蟎(Polyphagotarsonemun latus )、血紅扇頭蜱(Rhipicephalus sanguineus )、人疥蟎(Sarcoptes scabiei )、鱷梨頂冠癭蟎(Tegolophus perseaflorae )、二點葉蟎(Tetranychus urticae )、長食酪蟎(Tyrophagus longior )，以及狄氏瓦蟎(Varroa destructor )。(19) 真蜘蛛目 (Order Araneae ) 。特定屬之非窮舉性清單包括但不限於，斜蛛屬(Loxosceles spp. )、寡婦蛛屬(Latrodectus spp. )，以及漏斗蜘蛛屬(Atrax spp. )。特定物種之非窮舉性清單包括但不限於，棕色遁蛛(Loxosceles reclusa )、黑寡婦蜘蛛(Latrodectus mactans )，以及雪梨漏斗網蜘蛛(Atrax robustus) 。(20) 結閥綱 (Class Symphyla ) 。 特定物種之非窮舉性清單包括但不限於，白松蟲(Scutigerella immaculata )。(21) 粘管亞綱 (Subclass Collembola ) 。 特定物種之非窮舉性清單包括但不限於，黄星圓跳蟲(Bourletiella hortensis )、棘跳蟲(Onychiurus armatus )、跳蟲(Onychiurus fimetarius )，以及綠圓跳蟲(Sminthurus viridis )。(22) 圓形動物門 (Phylum Nematoda) 。特定屬之非窮舉性清單包括但不限於，線蟲屬(Aphelenchoides spp.)、刺線蟲屬(Belonolaimus spp.)、小環線蟲屬(Criconemella spp.)、莖線蟲屬(Ditylenchus spp.)、黃金線蟲屬(Globodera spp.)、孢囊線蟲屬(Heterodera spp.)、潛根線蟲屬(Hirschmanniella spp.)、紐帶線蟲屬(Hoplolaimus spp.)、根瘤線蟲屬(Meloidogyne spp.)、根腐線蟲屬(Pratylenchus spp.)及穿孔線蟲屬(Radopholus spp.)。特定物種之非窮舉性清單包括但不限於，犬惡絲蟲(Dirofilaria immitis )、馬鈴薯孢囊線蟲(Globodera pallida )、大豆孢囊線蟲(Heterodera glycines )、玉米胞囊線蟲(Heterodera zeae )、南方根結線蟲(Meloidogyne incognita )、爪哇根瘤線蟲(Meloidogyne javanica )、人蟠尾絲蟲(Onchocerca volvulus )、穿刺短體根腐線蟲(Pratylenchus penetrans )、相似穿孔線蟲(Radopholus similis )以及腎狀線蟲(Rotylenchus reniformis )。(23) 軟體動物門 ( Phylum Mollusca ) 。特定物種之非窮舉性清單包括但不限於，西班牙蛞蝓(Arion vulgaris )、螺旋蝸牛(Cornu aspersum )、網紋野蛞蝓(Deroceras reticulatum )、黄蛞蝓(Limax flavus )、溫室蛞蝓(Milax gagates )，以及福壽螺(Pomacea canaliculata )。Additional examples are the following pests: (1) Subphyla Chelicerata , Myriapoda , and Hexapoda . (2) Arachnida (Arachnida), Symphyla (Symphyla), and Insecta (Insecta). (3) Head lice (Order Anoplura). A non-exhaustive list of specific genera includes, but is not limited to, Haematopinus spp., Hoplopleura spp., Linognathus spp., Pediculus spp. Polyplax spp., Solenopotes spp., and Neohaematopinis spp. A non-exhaustive list of specific species includes, but is not limited to, Haematopinus asini , Haematopinus suis , Linognathus setosus , Linognathus ovillus , Pediculus humanus Capitis ), Pediculus humanus humanus and Pthirus pubis . (4) Coleoptera (Order Coleoptera) . A non-exhaustive list of specific genera includes, but is not limited to, Acanthoscelides spp., Agriotes spp., Anthonomus spp., Apion spp., and golden tortoise Genus ( Apogonia spp.), ( Araecerus spp.), Aulacophora spp., Bruchus spp., Cerosterna spp., Cerotoma spp. , genus ( Ceutorhynchus spp.), Chaetocnema spp., Colaspis spp., Ctenicera spp., Curculio spp., round head Cyclocephala spp., Diabrotica spp., Dinoderus spp., Gnathocerus spp., Hemicoelus spp., Aphididae Genus ( Heterobostruchus spp.), Hypericoptera ( Hyla spp.), Ips spp., Lyctus spp., Megascelis spp., genus Meligethes spp.), Mezium spp., Niptus spp., Otiorhynchus spp., Pantomorus spp., genus ( Phyllophaga spp.), Phyllotreta spp., Ptinus spp., Rhizotrogus spp., Rhynchites spp., Elephant genus Rhynchophorus spp.), Scolytus spp., Sphenophorus spp., Sitophilus spp., Tenebrio spp., and Quercus Tribolium spp.). A non-exhaustive list of specific species includes, but is not limited to, Acanthoscelides obtectus , Agrilus planipennis , Ahasverus advena , Alphitobius diaperinus , A. glabrata ( Anoplophora glabripennis ), Anthonomus grandis , Anthrenus verbasci , Anthrenus falvipes , Ataenius spretulus , Atomaria linearis , black fur Attagenus unicolor , Bothynoderes punctiventris , Bruchus pisorum , Callosobruchus maculatus , Carpophilus hemipterus , Cassida vittata , square neck squad Cathartus quadricollis ), Cerotoma trifurcata , Ceutorhynchus assimilis , Ceutorhynchus napi , Conoderus scalaris , Conoderus stigmosus , Li Weevil ( Conotrachelus nenuphar ), green turtle ( Cotinis nitida ) , Crioceris asparagi , Cryptolestes ferrugineus , Cryptolestes pusillus , Cryptolestes turcicus , Cylindrocopturus adspersus , Deporaus marginatus , Dermestes lardarius , Dermestes maculatus , Epilachna varivestis , Euvrilletta peltata , Faustinus cubae ), Hylobius pales , Hylotrupes bajulus , Hypera postica , Hypothenemus hampei , Lasioderma serricorne , Leptinotarsa decemlineata , Limonius canus , Liogenys fuscus , Liogenys suturalis , Lissorhoptrus oryzophilus , Lophocateres pusillus , Lyctus planicollis ), Maecolaspis joliveti , Melanotus communis , canola Meligethes aeneus , Melolontha melolontha , Necrobia rufipes , Oberea brevis , Oberea linearis , Oryctes rhinoceros , Oryzaephilus mercator , Oryzaephilus surinamensis , Oulema melanopus , Oulema oryzae , Phyllophaga cuyabana , Polycaon stoutti ), Popillia japonica , Prostephanus truncatus , Rhyzopertha dominica , Sitona lineatus , Sitophilus granarius , Sitophilus oryzae , corn ( Sitophilus zeamais ), Stegobium paniceum , Tenebroides mauritanicus , Tribolium castaneum , Tribolium confusum , Trogoderma granarium , tinea skin ( Trogoderma variabile ), red thief ( Xestobium rufovillosum ), and corn beetle ( Zabrus tenebrioides ). (5) Dermaptera (Order Dermaptera). A non-exhaustive list of specific genera includes, but is not limited to, Forficula auricularia . (6) Blattaria (Order Blattaria). A non-exhaustive list of specific species includes, but is not limited to, Blattella germanica , Blattella asahina , Blatta orientalis , Blatta lateralis , Pennsylvania Parcoblatta pennsylvanica , Periplaneta americana , Periplaneta australasiae , Periplaneta brunnea , Periplaneta fuliginosa , Pycnoscelus surinamensis , and long beard With 蠊 ( Supella longipalpa ). (7) Diptera (Order Diptera). A non-exhaustive list of specific genera includes, but is not limited to, Aedes spp., Agromyza spp., Anastrepha spp., Anopheles spp. fruit fly genus (Bactrocera spp.), is a Mediterranean fruit fly (Ceratitis spp.), is a spot fly (Chrysops spp.), worm fly genus (Cochliomyia spp.), midge genus (Contarinia spp.), house mosquito genera ( Culex spp.), Culicoides spp., Dasineura spp., Delia spp., Drosophila spp., Fannia spp. , black flies genus (Hylemya Hylemyia spp.), is a leafminer (Liriomyza spp.), is a housefly (Musca spp.), is a grass flies (Phorbia spp.), powder Musca (Pollenia spp.), moths Simulium (Psychoda spp.), Simulium (Simulium spp.), is a horsefly (Tabanus spp.) and large mosquito genera (Tipula spp.). Non-exhaustive lists of specific species include, but are not limited to, Agromyza frontella , Anastrepha suspensa , Anastrepha ludens , Anastrepha obliqua, and melon Bactrocera cucurbitae , Bactrocera dorsalis , Bactrocera invadens , Bactrocera zonata , Ceratitis capitata , Dasineura brassicae , ash species Fly ( Delia platura ), Fannia canicularis , Fannia scalaris , Gasterophilus intestinalis , Gracillia perseae , Haematobia irritans , Hypoderma lineatum , Liriomyza brassicae , Liriomyza sativa , Melophagus ovinus , Musca autumnalis , Musca domestica , Oestrus ovis , black straw flies (Oscinella frit), beet spring flies (Pegomya betae), Kai's cheese flies (Piophila casei), Hu Bu flies (Psila rosae), cherry fruit fly (Rhagoletis cerasi), apple fruit fly (Rhagoletis pomonella), Blue Orange around the fruit fly (Rhagoletis mendax), wheat midge (Sitodiplosis mosellana) and廄stable flies (Stomoxys calcitrans). (8) Hemiptera (Order Hemiptera). A non-exhaustive list of specific genera includes, but is not limited to, Adelges spp., Aulacaspis spp., Aphrophora spp., Aphis spp. Bemisia spp., Ceroplastes spp., Chionaspis spp., Chrysomphalus spp., Coccus spp. Empeoasca spp., Euschistus spp., Lepidosaphes spp., Lagynotomus spp., Lygus spp., long Macrosiphum spp., Nephotettix spp., Nezara spp., Nilaparvata spp., Philaenus spp., Phytophthora Genus ( Phytocoris spp.), genus Piezodorus spp., Planococcus spp., Pseudococcus spp., Rhopalosiphum spp., black helmet Saissetia spp., Therioaphis spp., Toumeyella spp., Toxoptera spp., Trial Eurodes spp.), Triatoma spp., and Unaspis spp. A non-exhaustive list of specific species includes, but is not limited to, Acrosternum hilare , Acyrthosiphon pisum , Aleyrodes proletella , Aleurodicus dispersus , and Aleurothrixus floccosus ), Amrasca biguttula biguttula , Aonidiella aurantii , Aphis fabae , Aphis gossypii , Aphis glycines , Aphis pomi , potato Lac ( Aulacorthum solani ), Bactericera cockerelli , Bagrada hilaris , Bemisia argentifolii , Bemisia tabaci , Blissus leucopterus , eucalyptus Maple tri ( Boisea trivittata ), Brachycorynella asparagi , Brevennia rehi , Brevicoryne brassicae , Cacopsylla pyri , Cacopsylla pyricola , Potato 蝽 ( Calocoris norvegicus ), red wax scale insect ( Ceroplastes rubens ), tropical bed bug ( Cime x hemipterus ), Cimex lectularius , Coccus pseudomagnoliarum , Dagbertus fasciatus , Dichelops furcatus , Diuraphis noxia , Diaphorina citri , Dysaphis plantaginea), black-winged red cotton bug (Dysdercus suturellus), Edessa meditabunda, false eye leafhopper (Empoasca vitis), woolly apple aphid (Eriosoma lanigerum), western grape leafhopper (Erythroneura elegantula), European flat shield bug (Eurygaster maura ), Euschistus conspersus , Euschistus heros , Euschistus servus , Halyomorpha halys , Helopeltis antonii , Hyalopterus pruni Helopeltis antonii , Helopeltis theivora , Icerya purchasi , Idioscopus nitidulus , Jacobiasca formosana , zebrafish ( Laodelphax striatellus ), Lecanium corni , Leptocorisa ora Torius ), Leptocorisa varicornis , Lygus hesperus , Maconellicoccus hirsutus , Macrosiphum euphorbiae , Macrosiphum granarium , Rose long Macrosiphum rosae , Macrosteles quadrilineatus , Mahanarva frimbiolata , Megacopta cribraria , Metopolophium dirhodum , Mictis longicornis , peach Myzus persicae , Nasonovia ribisnigri , Nephotettix cincticeps , Neurocolpus longirostris , Nezara viridula , Nilaparvata lugens , Paracoccus marginatus , Paratrioza cockerelli , Parlatoria pergandii , Parlatoria ziziphi , Peregrinus maidis , Phylloxera vitifoliae , cedar Kuwana (Physokermes piceae), California plant bugs (Phytocoris californicus), Lygus (Phytocoris relativus), intended GED wall bug (Piezodorus guildinii), orange buttocks pattern mealybug (Planococcus citri), the gluteal groove fig mealybug (Planococcus ficus), four-wire bugs (Poecilocapsus lineatus), Lygus ( Psallus vaccinicola ), Pseudacysta perseae , Pseudococcus brevipes , Quadraspidiotus perniciosus , Rhopalosiphum maidis , Rhopalosiphum padi , R. chinensis ( Saissetia oleae ), Scaptocoris castanea , Schizaphis graminum , Sitobion avenae , Sogatella furcifera , Trialeurodes vaporariorum , and winged wings Trionyurodes abutiloneus , Unaspis yanonensis and Zulia entrerriana . (9) Hymenoptera (Order Hymenoptera). A non-exhaustive list of specific genera includes, but is not limited to, Acromyrmex spp., Atta spp., Camponotus spp., Diprion spp. , Dolichovespula spp., Formica spp., Monomorium spp., Neodiprion spp., Paratrechina spp., antler Genus ( Pheidole spp.), Pogonomyrmex spp., Polistes spp., Solenopsis spp., Technomyrmex , spp., Tetramorium Spp.), Vespula spp., Vespa spp., and Xylocopa spp. A non-exhaustive list of specific species includes, but is not limited to, Athalia rosae , Atta texana , Caliroa cerasi , American horned bee ( Cimbex americana ), Aridomyrmex humilis , Linepithema humile , Mellifera Scutellata , Monomorium minimum , Monomorium pharaonis , Pine yellow leaves Neodiprion sertifer , Solenopsis invicta , Solenopsis geminata , Solenopsis molesta , Solenopsis richtery , Solenopsis xyloni , sour odorant Tapinoma sessile ), and the small fire ant ( Wasmannia auropunctata ). (10) Isoptera (Order Isoptera). A non-exhaustive list of specific genera includes, but is not limited to, Coptotermes spp., Cornitermes spp., Cryptotermes spp., Heterotermes spp. wood termites belong (Kalotermes spp.), Ying termites belong (Incisitermes spp.), termites belong (Macrotermes spp.), edge wood termite genus (Marginitermes spp.), saw termite genus (Microcerotermes spp.), the original angle termites Genus ( Procornitermes spp.), Reticulitermes spp., Schedorhinotermes spp. and Zootermopsis spp. A non-exhaustive list of specific species includes, but is not limited to, ( Coptotermes acinaciformis ), Coptotermes curvignathus , Coptotermes frenchii , Coptotermes formosanus , Coptotermes gestroi), hemp head heap of sand termites (Cryptotermes brevis), golden different termite (Heterotermes aureus), South America different termite (Heterotermes tenuis), small Ying termites (Incisitermes minor), Sri Lanka's Ying termites (Incisitermes snyderi), rice and wheat small termite ( Microtermes obesi ), Nasutitermes corniger , Odontotermes formosanus , Odontotermes obesus , Reticulitermes banyulensis , Reticulitermes grassei , Termites ( Reticulitermes flavipes ), Reticulitermes hageni , Reticulitermes hesperus , Reticulitermes santonensis , Reticulitermes speratus , Reticulitermes tibialis and nice Black subterranean termite (Reticulitermes virginicus). (11) Lepidoptera (Order Lepidoptera) . A non-exhaustive list of specific genera includes, but is not limited to, Adoxophyes spp., Agrotis spp., Argyrotaenia spp., Cacoecia spp. Caloptilia spp., Chilo spp., Chrysodeixis spp., Colias spp., Crambus spp., wilderness Diaphania spp., Diatraea spp., Earias spp., Ephestia spp., Epimecis spp., Spodoptera spp. Feltia spp.), Gortyna spp., Helicoverpa spp., Heliothis spp., Indarbela spp. , Locusta ( Lithocolletis spp.), Loxagrotis spp., Malacosoma spp., Nemapogon spp., Peridroma spp., genus Phyllonorycter spp.), Pseudaletia spp., Plutella spp., Sesamia spp., Spodoptera spp., Syringa ( Sy) Nanthedon spp.) and Yponomeuta spp. A non-exhaustive list of specific species includes, but is not limited to, Achaea janata , Adoxophyes orana , Agrotis ipsilon , Alabama argillacea , Amorbia cuneana , Amyelois transitella , Anacamptodes defectaria , Anarsia lineatella , Anomis sabulifera , Anticarsia gemmatalis , Archips argyrospila , Archips rosana , Argyrotaenia citrana , Autographa gamma , Bonagota cranaodes , Borbo cinnara ), cotton moth ( Bucculatrix thurberiella ), Capua reticulana , Carposina niponensis , Chlumetia transversa , Choristoneura rosaceana , and rice leaf roller ( Cnaphalocrocis medinalis), cocoa miner (Conopomorpha cramerella), rice conjugated outer moth (Corcyra cephalonica), Cossus moth (Cossus cossus), Walnut moth (Cydia caryana), Li moth (Cydia funebrana), pear moth (Cydia molesta), a small pea moth (Cydia nigricana), codling moth (Cydia pomonella), tea slug (Darna diducta), cucumber Diaphania nitidalis , Diatraea saccharalis , Diatraea graniosella , Earias insulata , Earias vitella , small rolls Ecdytolopha aurantianum , South American corn seedlings ( Elasmopalpus lignosellus ), Ephestia cautella, Ephestia elutella , Ephestia kuehniella , Epinotia aporema , light brown Epiphyas postvittana , Erionota thrax , Estigmene acrea , Eupoecilia ambiguella , Euxoa auxiliaris , Galleria mellonella , peach off heartworm (Grapholita molesta), three lines Pyralidae (Hedylepta indicata), cotton bollworm (Helicoverpa armigera), corn earworm (He Licoverpa zea ), Heliothis virescens , Hellula undalis , Keiferia lycopersicella , Leucinodes orbonalis , Leucoptera coffeella , striated dive Leucoptera malifoliella , Lobesia botrana , Loxagrotis albicosta , Lymantria dispar , Lyonetia clerkella , Mahasena corbetti , Mamestra brassicae , Manduca sexta , Maruca testulalis , Metisa plana , Mythimna unipuncta , Neoleucinodes elegantalis , White-water moth ( Nymphula depunctalis ), Operophtera brumata , Ostrinia nubilalis , Oxydia vesulia , Pandemis cerasana , Pandemis heparana , Africa Damour butterfly (Papilio demodocus), white coffee latent night insects (Pectinophora gossypiella), variegated armyworm (Peridroma saucia) Coffee leafminer (Perileucoptera coffeella), potato moth (Phthorimaea operculella), citrus latent armyworm (Phyllocnisitis citrella), spot curtain leafminer (Phyllonorycter blancardella), grain white butterfly (Pieris rapae), alfalfa green armyworm (Plathypena scabra) , Platynota idaeusalis , Plodia interpunctella , Plutella xylostella , Polychrosis viteana , Prays endocarpa , Prays oleae , Pseudaletia unipuncta , Pseudoplusia includens , Rachiplusia nu , Scirpophaga incertulas , Sesamia inferens , Sesamia Nonagrioides ), Setora nitens , Sitotroga cerealella , Sparganothis pilleriana , Spodoptera exigua , Spodoptera fugiperda , Southern Spodoptera (Spodoptera eridania), pineapple gray brown butterfly (Thecla basilides), Moth (Tinea pellionella), webbing clothes moth (Tineola bisselliella), pink spots armyworm (Trichoplusia ni), tomato leafminer (Tuta absoluta), coffee leopard moth (Zeuzera coffeae) and pear leopard moth (Zeuzera pyrina). (12) Mallophaga (Order Mallophaga). A non-exhaustive list of specific genera includes, but is not limited to, Anaticola spp., Bovicola spp., Chelopistes spp., Goniodes spp. ), Menacanthus spp. and Trichodectes spp. Non-exhaustive lists of specific species include, but are not limited to, Bovicola bovis , Bovicola caprae , Bovicola ovis , Chelopistes meleagridis , and chicken horns ( Goniodes dissimilis ), Goniodes gigas , Menacanthus stramineus , Menopon gallinea , and Trichodectes canis . (13) Orthoptera (Order Orthoptera). A non-exhaustive list of specific genera includes, but is not limited to, Melanoplus spp. and Pterophylla spp. Non-exhaustive lists of specific species include, but are not limited to, Acheta domesticus , Anabrus simplex , Gryllotalpa africana , Gryllotalpa australis , Gryllotalpa brachyptera , Gryllotalpa hexadactyla , Locusta migratoria , Microcentrum retinerve , Schistocerca gregaria , and Scudderia furcata . (14) Psocoptera (Order Psocoptera). A non-exhaustive list of specific species includes, but is not limited to, Liposcelis decolor , Liposcelis entomophila , Lachesilla quercus , and Trogium pulsatorium . (15) Siphonaptera (Order Siphonaptera). A non-exhaustive list of specific species includes, but is not limited to, Ceratophyllus gallinae , Ceratophyllus niger , Ctenocephalides canis , Ctenocephalides felis , and People ( Pulex irritans ). (16) Thysanoptera (Order Thysanoptera). A non-exhaustive list of specific genera includes, but is not limited to, Caliothrips spp., Frankliniella spp., Scirtothrips spp., and Thrips spp. .). A non-exhaustive list of specific species includes, but is not limited to, Caliothrips phaseoli , Frankliniella bispinosa , Frankliniella fusca , Frankliniella occidentalis , Frankliniella schultzei , Frankliniella tritici , Frankliniella williamsi , Heliothrips haemorrhaidalis , Rhipiphorothrips cruentatus , orange hard Scirtothrips citri , Scirtothrips dorsalis , Taeniothrips rhopalantennalis , Thrips hawaiiensis , Thrips nigropilosus , Thrips orientalis , Thrips palmi , and Thrips tabaci . (17) Thysanoptera (Order Thysanura). A non-exhaustive list of specific genera includes, but is not limited to, Lepisma spp. and Thermobia spp. (18) Acarina (Order Acarina). A non-exhaustive list of specific genera include but are not limited to, metal powder mite (Acarus spp.), Ticks genus puncture the skin section (Aculops spp.), Argus genus (Argus spp.), Cattle ticks genus (Boophilus spp.) , Demodex spp., Dermacentor spp., Epitimerus spp., Eriophyes spp., Ixodes spp., red leaves Oligonychus spp., Panonychus spp., Rhizoglyphus spp., and Tetranychus spp. A non-exhaustive list of specific species includes, but is not limited to, Acarapis woodi , Acarus siro , Aceria mangiferae , Aculops lycopersici , and skin. Aculus pelekassi , Aculus schlechtendali , Amblyomma americanum , Brevipalpus obovatus , Brevipalpus phoenicis , variant leather Dermacentor variabilis , Dermatophagoides pteronyssinus , Eotetranychus carpini , Liponyssoides sanguineus , Notoedres cati , Oligonychus coffe a e ), Oligonychus ilicis , Ornithonyssus bacoti , Panonychus citri , Panonychus ulmi , Phyllocoptruta oleivora , Polyphagotarsonemun latus , Rhipicephalus sanguineus , Sarcoptes scabiei , crocodile Tegolophus perseaflorae , Tetranychus urticae , Tyrophagus longior , and Varroa destructor . (19) True Spiders (Order Araneae). A non-exhaustive list of specific genera include but are not limited to, belong to the swash spider (Loxosceles spp.), The genus widow spider (Latrodectus spp.), And the genus funnel spider (Atrax spp.). A non-exhaustive list of specific species includes, but is not limited to, Loxosceles reclusa , Latrodectus mactans , and Atrax robustus . (20) a valve junction classes (Class Symphyla). A non-exhaustive list of specific species includes, but is not limited to, Scutigerella immaculata . (21) Viscosity tube subclass (Subclass Collembola). Non-exhaustive lists of specific species include, but are not limited to, Bourletiella hortensis , Onychiurus armatus , Onychiurus fimetarius , and Sminthurus viridis . (22) round the phylum (Phylum Nematoda). A non-exhaustive list of specific genera includes, but is not limited to, Aphelenchoides spp., Belonolaimus spp., Criconemella spp., Ditylenchus spp., gold. Globodera spp., Heterodera spp., Hirschmanniella spp., Hoplolaimus spp., Meloidogyne spp., Rhizoctonia genus ( Prtylenchus spp.) and the genus Radopholus spp. A non-exhaustive list of specific species includes, but is not limited to, Dirofilaria immitis , Globodera pallida , Heterodera glycines , Heterodera zeae , Southern Meloidogyne incognita , Meloidogyne javanica , Onchocerca volvulus , Pratylenchus penetrans , Radopholus similis , and Renal nematodes ( Rotylenchus) Reniformis ). (23) Mollusc ( Phylum Mollusca ) . Non-exhaustive lists of specific species include, but are not limited to, Arion vulgaris , Cornu aspersum , Deroceras reticulatum , Limax flavus , Milax gagates , and Pomacea canaliculata .

特別佳要控制的害蟲群組是取食汁液之害蟲。取食汁液之害蟲 ，一般說來，具有銳利及/或吸吮的口器，並且取食汁液與植物之內部植物組織。農業特別關注的取食汁液之害蟲的實例含括但不限於，蚜蟲、葉蟬、蛾、介殼蟲(scales)、薊馬(thrips)、木蝨(psyllids)、水蠟蟲(mealybugs)、臭蟲，以及粉虱。農業關注的取食汁液之害蟲的特定目實例含括但不限於，虱目(Order Anoplura)及半翅目(Order Hemiptera)。農業關注的半翅目特定實例含括但不限於，輪盾介殼蟲屬(Aulacaspis spp.)、沫蟬屬(Aphrophora spp.)、蚜蟲屬(Aphis spp.)、粉虱屬(Bemisia spp.)、介殼蟲屬(Coccus spp.)、美洲蝽屬(Euschistus spp.)、草盲蝽屬(Lygus spp.)、長管蚜屬(Macrosiphum spp.)、稻綠蝽屬(Nezara spp.)，以及縊管蚜屬(Rhopalosiphum spp.)。A group of pests that are particularly well controlled are pests that feed on juice. Pests that feed on sap , in general, have sharp and/or sucking mouthparts and feed on the internal plant tissues of the juice and plants. Examples of pests that are of particular interest to agriculture in agriculture include, but are not limited to, aphids, spider mites, moths, scales, thrips, psyllids, melybugs, bed bugs. , and pink. Specific examples of pests of agricultural concern for feeding sap include, but are not limited to, Order Anoplura and Order Hemiptera. Specific examples of Hemiptera of agricultural concern include, but are not limited to, Aulacaspis spp., Aphrophora spp., Aphis spp., Bemisia spp. , Coccus spp., Euschistus spp., Lygus spp., Macrosiphum spp., Nezara spp., and Rhopalosiphum spp.

另一特別佳要控制的害蟲群組是嚼食性害蟲。嚼食性害蟲 ，一般說來，具有銳利及/或吸吮的口器使其等能嚼食植物組織，含括根、莖、葉及生殖組織(含括但不限於，花、果實及種子)。農業關注的嚼食性害蟲的實例含括但不限於，毛蟲、甲蟲、蚱蜢及蝗蟲。農業關注的嚼食性害蟲的特定目實例含括但不限於，鞘翅目(Coleoptera)及鱗翅目(Lepidoptera)。農業關注的鞘翅目之特定實例含括但不限於，豆象屬(Acanthoscelides spp.)、豆葉甲蟲屬(Cerotoma spp.)、跳甲屬(Chaetocnema spp.)、肖葉甲蟲屬(Colaspis spp.)、圓頭犀金龜屬(Cyclocephala spp.)、葉甲屬(Diabrotica spp.)、葉象屬(Hypera spp.)、鰓角金龜屬(Phyllophaga spp.)、菜葉蚤屬(Phyllotreta spp.)、禾象鼻蟲屬(Sphenophorus spp.)、米象屬(Sitophilus spp.)。Another group of pests that are particularly well controlled are chewing pests. Chewing pests , in general, have sharp and/or sucking mouthparts that allow them to chew plant tissue, including roots, stems, leaves, and reproductive tissues (including but not limited to flowers, fruits, and seeds). Examples of chewing pests of agricultural interest include, but are not limited to, caterpillars, beetles, mites, and mites. Specific examples of agriculturally focused chewing pests include, but are not limited to, Coleoptera and Lepidoptera. Specific examples of coleoptera of agricultural concern include, but are not limited to, Acanthoscelides spp., Cerotoma spp., Chaetocnema spp., Colaspis spp. ), Cyclocephala spp., Diabrotica spp., Hypera spp., Phyllophaga spp., Phyllotreta spp. , Sphenophorus spp., Sitophilus spp.

用語「殺蟲 有效量 」意指對害蟲達成可觀察到的效應所需要的殺蟲劑量，舉例而言壞死、死亡、遲緩、預防、移除、破壞的效應，不然就是能減少害蟲於一所在地的發生及/或害蟲的活性。於一所在地驅逐害蟲族群，害蟲於一所在地或附近無行為能力，以及/或是害蟲於一所在地或附近消滅的時候，可產生此效應。當然，可發生此等效應之組合。一般而言，害蟲族群、活性或是二者都希望降低超過百分之五十，較佳為超過百分之九十，且最佳為超過百分之九十九。通常，對於農業目的，殺蟲有效量為從大約每公頃0.0001公克至大約每公頃5000公克，較佳為從大約每公頃0.0001公克至大約每公頃500公克，以及還更佳為從大約每公頃0.0001公克至大約每公頃50 公克。The term " insecticidally effective amount " means the insecticidal dose required to achieve an observable effect on a pest, for example, the effects of necrosis, death, delay, prevention, removal, destruction, or otherwise reduce the pest in one location. Occurrence and/or activity of pests. This effect can occur when a pest population is expelled at a location where the pest is incapable at or near a location and/or when the pest is destroyed at or near a location. Of course, a combination of these effects can occur. In general, the pest population, activity, or both are desirably reduced by more than fifty percent, preferably by more than ninety percent, and most preferably by more than ninety-nine percent. Generally, for agricultural purposes, the pesticidally effective amount is from about 0.0001 grams per hectare to about 5000 grams per hectare, preferably from about 0.0001 grams per hectare to about 500 grams per hectare, and still more preferably from about 0.0001 per hectare. The gram is about 50 grams per hectare.

較佳實施例之詳細說明 本文件揭示式 1 分子 式1 其中：(A)       Ar1 係選自於下列所構成的群組：呋喃基、苯基、嗒基、吡啶基、嘧啶基，或是噻吩基， 其中每個呋喃基、苯基、嗒基、吡啶基、嘧啶基，及噻吩基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(B)       Het 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子，以及其中Ar1 與L1 互相不為鄰位，但可為間位或對位，例如就5員環而言，其等為1,3，且就6員環而言，其等為1,3或1,4， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(C)       L1 係選自於下列所構成的群組：(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基，以及(C2 -C6 )炔基， 其中每個烷基、鹵烷基、環烷基、烯基及炔基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基，以及(C2 -C6 )炔基；(D)       Ar2 係選自於下列所構成的群組：呋喃基、苯基、嗒基、吡啶基、嘧啶基，或是噻吩基， 其中每個呋喃基、苯基、嗒基、吡啶基、嘧啶基，及噻吩基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(E) R15 係選自於下列所構成的群組：H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、C(O)-NRx Ry 、C(O)-苯基、(C1 -C4 )烷基-NRx Ry 、C(O)O-(C1 -C4 )烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基，以及(C1 -C4 )烷基-OC(=O)O-(C1 -C4 )烷基， 其中每個烷基、環烷基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(F) Q1 係選自於O及S所構成的群組；(G)Q2 係選自於O及S所構成的群組；(H) R16 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基)、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(I) R17 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(J) L2 係選自於下列所構成的群組：(C3 -C8 )環烷基、苯基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、(C2 -C6 )烯基-O-苯基、(Het-1)、(C1 -C4 )烷基-(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)； 其中每個烷基、環烷基、烯基、苯基，及(Het-1)取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)；(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起形成一個4-至7-員飽和或不飽和之烴基環(hydrocarbyl cyclic)基團，其可以進一步含有選自於氮、硫或氧所構成的群組之一個或更多個雜原子， 其中該烴基環基團可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：側氧、R18 及R19 ， 其中R18 及R19 係各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、側氧、硫酮基、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(L) Rx 及Ry 係各自獨立地選自於下列所構成的群組：H、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基，以及苯基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(M)      (Het-1) 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(N) n 每一者係獨立地為0、1或2；以及       式1的分子之N-氧化物、農業上可接受的酸加成鹽類、鹽類衍生物、溶劑合物、結晶性多形體、同位素、解析的立體異構物，以及互變異構物。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS This document discloses Formula 1 molecule Formula 1 wherein: (A) Ar 1 is selected from the following group consisting of: furyl, phenyl, despair a pyridyl group, a pyrimidinyl group, or a thienyl group, wherein each furanyl group, phenyl group, hydrazine group The base, pyridyl, pyrimidinyl, and thienyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 - C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n - (C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-( C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-( C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl -O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 An alkyl-C(O)O-(C 1 -C 4 )alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group Alkenyl, alkynyl, phenyl, and phenoxy substituted May be selectively one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkoxy , (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C (O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C (O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkane , (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-( C 1 -C 4 )alkyl, phenyl, and phenoxy; (B) Het is a 5 or 6 membered, saturated or unsaturated heterocyclic ring containing one or more independently selected from nitrogen, sulfur or oxygen. heteroatoms, and wherein each Ar 1 to L 1 is not a position, but may be a meta or a para position, for example, for a 5-membered ring, it is 1, 3, and in the case of a 6-membered ring, it is 1, 3 or 1, 4, wherein each heterocyclic ring It may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C) 4 ) an alkyl group, a (C 1 -C 4 )haloalkyl group, a (C 3 -C 8 )cycloalkyl group, a (C 1 -C 4 )alkoxy group, a (C 1 -C 4 )halo alkoxy group, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )halide Alkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl- NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )halane , C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkane , C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O) O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkane The group, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, phenyl, and phenoxy substituents may be optionally independently selected from one or more of the following The substituents of the group formed are substituted: H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl , S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 - (C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl , C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C( O) O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy (C) L 1 is selected from the group consisting of: (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, and (C 2 -C 6 )alkynyl, Wherein each alkyl, haloalkyl, cycloalkyl, alkenyl and alkynyl group may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 ) Alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, and (C 2 -C 6 )alkynyl; (D) Ar 2 is selected from the following Group: furyl, phenyl, hydrazine a pyridyl group, a pyrimidinyl group, or a thienyl group, wherein each furanyl group, phenyl group, hydrazine group The base, pyridyl, pyrimidinyl, and thienyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 - C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n - (C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-( C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-( C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl -O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 An alkyl-C(O)O-(C 1 -C 4 )alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group Alkenyl, alkynyl, phenyl, and phenoxy substituted May be selectively one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkoxy , (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C (O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C (O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkane , (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O)O- (C 1 -C 4 )alkyl, phenyl, and phenoxy; (E) R 15 is selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 3 - C 8) cycloalkyl, (C 2 -C 6) alkenyl, (C 2 -C 6) alkynyl group, S (O) n - ( C 1 -C 4) alkoxy , C (O) -NR x R y, C (O) - phenyl, (C 1 -C 4) alkyl group -NR x R y, C (O ) O- (C 1 -C 4) alkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C( O) O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O) -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, and (C 1 -C 4 )alkyl-OC ( =O)O-(C 1 -C 4 )alkyl, wherein each alkyl, cycloalkyl, alkenyl, alkynyl, and phenyl group may be optionally independently selected from one or more of the following The substituents of the group formed are substituted: H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 Alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 Alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 ) alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O)O-(C 1 -C 4 ) alkyl, phenyl, and phenoxy; (F) Q 1 is selected from O and S in the group consisting of; (G) Q 2 is selected from O and S in the group consisting of; (H) R 16 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, C(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, C(O)-(Het-1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-C(O)-(Het-1) (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (NR x R y )-C(O)OH, (C 1 -C 4 ) Alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-NR x R y ,(C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-C(O)-N(R x ) (C 1 -C 4 )alkyl (N(R x )-C(O)O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 )alkyl-C (O)-(Het-1)-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 ) alkane (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3 -C 8 ) ring Alkyl, (C 1 -C 4 )alkyl-OC(O)-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl-N (R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl-S(O) n -(Het-1), and (C 1 -C 4 )alkyl-O-(Het-1), wherein each alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, and (Het- 1) may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , NR x R y , ( C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(=O) n -(C 1 -C 4 )alkyl, S ( =O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H,C (O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-( C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 - C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl), phenyl, phenoxy, Si ((C 1 -C 4 )alkyl) 3 , S(=O) n -NR x R y , and (Het-1); (I) R 17 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl,C(O)-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 Alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, C(O)-(Het -1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, ( C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl- (Het-1), (C 1 -C 4 )alkyl-C(O)-(Het-1), (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (NR x R y )-C(O)OH, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl(N(R x )-C(O)O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 )alkyl-C(O)-(Het-1)-C(O)O-(C 1 -C 4 ) alkane (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 ) Alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkyl-OC(O)-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl-S(O) n -(Het-1), and (C 1 -C 4 )alkyl-O-(He T-1), wherein each alkyl group, cycloalkyl group, alkenyl group, alkynyl group, phenyl group, and (Het-1) may be optionally selected from the group consisting of one or more independently selected from the group consisting of Substituents of the group are substituted: H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3- C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(=O) n -(C 1 -C 4 )alkyl, S(=O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )halane Base, C(O)H, C(O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 Alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )halide Alkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl , C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S (O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, benzene Oxy, Si((C 1 -C 4 )alkyl) 3 , S(=O) n -NR x R y , and (Het-1); (J) L 2 is selected from Group consisting of (C 3 -C 8 )cycloalkyl, phenyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, (C 2 -C 6 )alkenyl-O-phenyl, (Het-1), (C 1 -C 4 )alkyl-(Het-1), and (C 1 -C 4 )alkyl-O-(Het And -1), wherein each alkyl group, cycloalkyl group, alkenyl group, phenyl group, and (Het-1) may be optionally one or more substituents independently selected from the group consisting of the following: Substituted: H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 a cycloalkyl group, a (C 1 -C 4 ) alkoxy group, a (C 1 -C 4 )haloalkoxy group, a (C 2 -C 6 )alkenyl group, a (C 2 -C 6 )alkynyl group, S ( O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 ) haloalkyl, C(O)H, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 Alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )halide Alkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl , C(O)O-(C 2 -C 6 )alkenyl, O-(C 1 -C 4 )alkyl, S- (C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O O-(C 1 -C 4 )alkyl, phenyl, phenoxy, and (Het-1); wherein each alkyl, cycloalkyl, alkenyl, phenyl, and (Het-1) substituted The group may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )halane Oxyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 ) haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-NR x R y , ( C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)- (C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O- (C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, O-(C 1 -C 4 Alkyl, S-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, C ( O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, phenoxy, and (Het-1); (K) R 16 and R 17 together with C x (Q 2 )(N x ) forms a 4- to 7-membered saturated or unsaturated hydrocarbyl cyclic group, which may further comprise a compound selected from the group consisting of nitrogen, sulfur or oxygen. One or more heteroatoms of the group, wherein the hydrocarbyl ring group may be optionally substituted with one or more substituents independently selected from the group consisting of: side oxygen, R 18 and R 19 , wherein R 18 and R 19 are each independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, thioketone, (C 1 -C) 4 ) an alkyl group, a (C 1 -C 4 )haloalkyl group, a (C 3 -C 8 )cycloalkyl group, a (C 1 -C 4 )alkoxy group, a (C 1 -C 4 )halo alkoxy group, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )halide Alkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-(C 1 -C 4 )alkyl , C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C (O) - (C 3 -C 8) Alkyl, C (O) O- (C 3 -C 8) cycloalkyl, C (O) - (C 2 -C 6) alkenyl, C (O) O- (C 2 -C 6) alkenyl (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C (O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and (Het-1); (L) R x and R y each Independently selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 - C 4 ) alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 ) alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C (O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )halane , C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkane , C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O) O- (C 1 -C 4) alkyl, and phenyl, wherein each alkyl, haloalkyl The cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, and phenyl groups may be optionally substituted with one or more substituents independently selected from the group consisting of: H , F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 - C 4 ) alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 ) alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C (O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )halane , C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkane , C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O) O-(C 1 -C 4 )alkyl, phenyl, and (Het-1); (M) (Het-1) is a 5- or 6-membered, saturated or unsaturated heterocyclic ring containing independently selected from One or more heteroatoms of nitrogen, sulfur or oxygen, of which Heterocyclyl may optionally be one or more substituents independently selected from the group consisting of the substituent group to be substituted with the following: 2, the oxygen side H, F, Cl, Br, I, CN, NO, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )halane Oxyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 ) haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 ) Alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 Haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 a cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C (O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkyne a base, a phenyl group, and a phenoxy substituent may be optionally One or more substituents independently selected from the group consisting of the group to be substituted with the following: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkyl, (C 1 -C 4 ) haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 ) alkene , (C 2 -C 6 ) alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O )-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O- (C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-( C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 An alkyl group, a phenyl group, and a phenoxy group; (N) n each independently being 0, 1 or 2; and a molecular N-oxide of the formula 1, an agriculturally acceptable acid addition salt , salt derivatives, solvates, crystalline polymorphs, same Su, resolved stereoisomers, and tautomers thereof.

式1分子可以以不同的幾何或光學異構物或是不同的互變異構物形式存在。可以存在一個或更多個掌性中心，在這種情況下，式1分子可以存在為純的鏡相異構物、鏡相異構物混合物、純的非鏡相異構物或是非鏡相異構物混合物。熟習此項技術者將瞭解，一種立體異構物可比其他立體異構物更具活性。個別立體異構物可藉由已知的選擇性合成程序獲得、使用經解析之起始物質藉由習知合成程序獲得，或是藉由習知解析程序來獲得。該分子內可能存在雙鍵，在這種情況下，式1分子可以存在為單一的幾何異構物(順式或反式，E 或Z )，或是幾何異構物(順式及反式，E 及Z )之混合物。可以存在互變異構中心。本揭露內容涵蓋所有此等異構物、互變異構物，以及其等所有比例之混合物。本揭露內容中繪出的結構僅用於清楚說明幾何形式，不應理解為代表該分子之所有幾何形式。The molecules of Formula 1 can exist in different geometric or optical isomers or in different tautomeric forms. There may be one or more palmar centers, in which case the molecule of formula 1 may be present as a pure mirror isomer, a mixture of mirror isomers, a pure non-mirror isomer or a non-mirror phase A mixture of isomers. Those skilled in the art will appreciate that one stereoisomer may be more active than other stereoisomers. Individual stereoisomers can be obtained by known selective synthetic procedures, obtained using analytical starting materials by conventional synthetic procedures, or by conventional analytical procedures. There may be double bonds in the molecule, in which case the molecule of formula 1 can exist as a single geometric isomer (cis or trans, E or Z ) or as a geometric isomer (cis and trans) , a mixture of E and Z ). A tautomeric center can exist. The disclosure encompasses all such isomers, tautomers, and mixtures thereof in all ratios. The structures depicted in this disclosure are only intended to illustrate the geometric form and are not to be construed as representing all geometric forms of the molecule.

在另一個具體例中，Ar1 為(1a) (1a) ， 其中：(1) X1 為N或CR1 ，其中R1 為H；(2) R2 及R4 各自獨立地為H；(3) R3 為(C1 -C4 )鹵烷基或(C1 -C4 )鹵烷氧基；以及(4) R5 為H或Cl。In another specific example, Ar 1 is (1a) (1a) , wherein: (1) X 1 is N or C R 1 , wherein R 1 is H; (2) R 2 and R 4 are each independently H; (3) R 3 is (C 1 -C 4 a haloalkyl group or a (C 1 -C 4 ) haloalkoxy group; and (4) R 5 is H or Cl.

本具體例可與Het 、L1 、Ar2 、R15 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。This specific example can be used in combination with other specific examples of Het , L 1 , Ar 2 , R 15 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，Ar1 為(1a) ，其中R3 為CF3 或OCF3 。本具體例可與X1 、R1 、R2 、R4 、R5 、Het 、L1 、Ar2 、R15 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another embodiment, Ar 1 is (1a) wherein R 3 is CF 3 or OCF 3 . This specific example may be other specific examples of X 1 , R 1 , R 2 , R 4 , R 5 , Het , L 1 , Ar 2 , R 15 , Q 1 , Q 2 , R 16 , R 17 , and L 2 . Used in combination.

在另一個具體例中，Het 為(1b) (1b) ， 其中R6 為H。本具體例可與Ar1 、L1 、Ar2 、R15 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another specific example, Het is (1b) (1b) , wherein R 6 is H. This specific example can be used in combination with other specific examples of Ar 1 , L 1 , Ar 2 , R 15 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，L1 為(1c) (1c) ， 其中R7 及R8 各自獨立地為H。本具體例可與Ar1 、Het 、Ar2 、R15 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another specific example, L 1 is (1c) (1c) wherein R 7 and R 8 are each independently H. This specific example can be used in combination with other specific examples of Ar 1 , Het , Ar 2 , R 15 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，L1 為(1d) (1d) ，其中R7 、R8 、R9 及R10 各自獨立地為H。本具體例可與Ar1 、Het 、Ar2 、R15 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another specific example, L 1 is (1d) (1d) wherein R 7 , R 8 , R 9 and R 10 are each independently H. This specific example can be used in combination with other specific examples of Ar 1 , Het , Ar 2 , R 15 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，L1 為(1d) ，其中R7 為(C1 -C4 )烷基。本具體例可與Ar1 、Het 、R8 、R9 、R10 、Ar2 、R15 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another embodiment, L 1 is (1d) wherein R 7 is (C 1 -C 4 )alkyl. This specific example can be used in combination with other specific examples of Ar 1 , Het , R 8 , R 9 , R 10 , Ar 2 , R 15 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，L1 為(1d) ，其中R7 為CH3 。本具體例可與Ar1 、Het 、R8 、R9 、R10 、Ar2 、R15 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another embodiment, L 1 is (1d) wherein R 7 is CH 3 . This specific example can be used in combination with other specific examples of Ar 1 , Het , R 8 , R 9 , R 10 , Ar 2 , R 15 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，L1 為(1e) (1e) ，其中R7 、R8 、R9 及R10 各自獨立地為H。本具體例可與Ar1 、Het 、Ar2 、R15 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another specific example, L 1 is (1e) (1e) wherein R 7 , R 8 , R 9 and R 10 are each independently H. This specific example can be used in combination with other specific examples of Ar 1 , Het , Ar 2 , R 15 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，Ar2 為(1f) (1f) ， 其中：(1) R11 為H、F、(C1 -C4 )烷基或(C1 -C4 )烷氧基；(2) R12 為H、F、Cl、(C1 -C4 )鹵烷基、(C1 -C4 )烷氧基，或是C(O)O-(C1 -C4 )烷基；(3) X2 為N或CR13 ，其中R13 為H、F、Cl、(C1 -C4 )鹵烷基、(C1 -C4 )烷氧基，或是C(O)O-(C1 -C4 )烷基；以及(4) R14 為H或F。In another specific example, Ar 2 is (1f) (1f) , wherein: (1) R 11 is H, F, (C 1 -C 4 )alkyl or (C 1 -C 4 )alkoxy; (2) R 12 is H, F, Cl, ( C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, or C(O)O-(C 1 -C 4 )alkyl; (3) X 2 is N or C R 13 Wherein R 13 is H, F, Cl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, or C(O)O-(C 1 -C 4 )alkyl And (4) R 14 is H or F.

本具體例可與Ar1 、Het 、L1 、R15 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , R 15 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，Ar2 為(1f) ，其中R11 為CH3 或OCH3 。本具體例可與Ar1 、Het 、L1 、R12 、X2 、R13 、R14 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another embodiment, Ar 2 is (1f) wherein R 11 is CH 3 or OCH 3 . This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , R 12 , X 2 , R 13 , R 14 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，Ar2 為(1f) ，其中R12 為CF3、OCH3 ，或是C(O)O-CH3 。本具體例可與Ar1 、Het 、L1 、R11 、X2 、R13 、R14 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another embodiment, Ar 2 is (1f) wherein R 12 is CF3, OCH 3 , or C(O)O-CH 3 . This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , R 11 , X 2 , R 13 , R 14 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，Ar2 為(1f) ，其中R13 為CF3、OCH3 ，或是C(O)O-CH3 。本具體例可與Ar1 、Het 、L1 、R11 、R12 、X2 、R14 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another embodiment, Ar 2 is (1f) wherein R 13 is CF3, OCH 3 , or C(O)O-CH 3 . This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , R 11 , R 12 , X 2 , R 14 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，R15 為H。本具體例可與Ar1 、Het 、L1 、Ar2 、Q1 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another embodiment, R 15 is H. This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , Ar 2 , Q 1 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，Q1 為O。本具體例可與Ar1 、Het 、L1 、Ar2 、R15 、Q2 、R16 、R17 ，及L2 之其他具體例組合使用。In another specific example, Q 1 is O. This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , Ar 2 , R 15 , Q 2 , R 16 , R 17 , and L 2 .

在另一個具體例中，Q2 為S。本具體例可與Ar1 、Het 、L1 、Ar2 、R15 、Q1 、R16 、R17 ，及L2 之其他具體例組合使用。In another specific example, Q 2 is S. This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , Ar 2 , R 15 , Q 1 , R 16 , R 17 , and L 2 .

在另一個具體例中，L2 為(1g) (1g) ， 其中：(1) R20 為F、Cl、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基，或是(C1 -C4 )烷基-O-(C1 -C4 )烷基，其中每個烷基、鹵烷基、環烷基、烷氧基，及鹵烷氧基可以以一個或更多個F取代基予以取代；(2) R21 為H；(3) R22 為H或F；(4) R23 為(C1 -C4 )烷基或(C1 -C4 )鹵烷基；以及(5) R24 為H。In another specific example, L 2 is (1 g) (1g) , wherein: (1) R 20 is F, Cl, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 ) alkoxy, (C 1 -C 4 )haloalkoxy, or (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, wherein each alkyl group , haloalkyl, cycloalkyl, alkoxy, and haloalkoxy may be substituted with one or more F groups be substituted; (2) R 21 is H; (3) R 22 is H or F; ( 4) R 23 is (C 1 -C 4 )alkyl or (C 1 -C 4 )haloalkyl; and (5) R 24 is H.

本具體例可與Ar1 、Het 、L1 、Ar2 、R15 、Q1 、Q2 、R16 及R17 之其他具體例組合使用。This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , Ar 2 , R 15 , Q 1 , Q 2 , R 16 and R 17 .

在另一個具體例中，L2 為(1g) ，其中R20 為CH2 CH2 CH3 、CH(CH3 )2 、CF3 、環丙基、OCH3 、OCH2 CH3 、OCH(CH3 )2 、OCH(CH3 )CH2 CH3 、OC(CH3 )3 、OCF3 、OCH2 CF3 、CH2 OCH3 ，或是CH(CH3 )OCH3 。本具體例可與Ar1 、Het 、L1 、Ar1 、Q1 、Q2 、R16 、R17 、R21 、R22 、R23 ，及R24 之其他具體例組合使用。In another embodiment, L 2 is (1 g) wherein R 20 is CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , CF 3 , cyclopropyl, OCH 3 , OCH 2 CH 3 , OCH (CH) 3 ) 2 , OCH(CH 3 )CH 2 CH 3 , OC(CH 3 ) 3 , OCF 3 , OCH 2 CF 3 , CH 2 OCH 3 , or CH(CH 3 )OCH 3 . This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , Ar 1 , Q 1 , Q 2 , R 16 , R 17 , R 21 , R 22 , R 23 , and R 24 .

在另一個具體例中，L2 為(1g) ，其中R23 為CH3 或CF3 。本具體例可與Ar1 、Het 、L1 、Ar2 、Q1 、Q2 、R16 、R17 、R21 、R22 、R23 ，及R24 之其他具體例組合使用。In another embodiment, L 2 is (1 g) wherein R 23 is CH 3 or CF 3 . This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , Ar 2 , Q 1 , Q 2 , R 16 , R 17 , R 21 , R 22 , R 23 , and R 24 .

在另一個具體例中，L2 為(1h) (1h) ，其中R20 、R21 、R22 、R23 及R24 各自獨立地為H。本具體例可與Ar1 、Het 、L1 、Ar2 、R15 、Q1 、Q2 、R16 ，及R17 之其他具體例組合使用。In another specific example, L 2 is (1h) (1h) wherein R 20 , R 21 , R 22 , R 23 and R 24 are each independently H. This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , Ar 2 , R 15 , Q 1 , Q 2 , R 16 , and R 17 .

在另一個具體例中，R16 及R17 與Cx (Q2 )(Nx ) 一起，為(1i) (1i) ，其中R18 及R19 各自獨立地為H。本具體例可與Ar1 、Het 、L1 、Ar2 、R15 、Q1 ，及L2 之其他具體例組合使用。In another specific example, R 16 and R 17 together with C x (Q 2 )(N x ) are (1i) (1i) wherein R 18 and R 19 are each independently H. This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , Ar 2 , R 15 , Q 1 , and L 2 .

在另一個具體例中，R16 及R17 與Cx (Q2 )(Nx ) 一起，為(1j) (1j) ，其中R18 及R19 各自獨立地為H。本具體例可與Ar1 、Het 、L1 、Ar2 、R15 、Q1 ，及L2 之其他具體例組合使用。In another specific example, R 16 and R 17 together with C x (Q 2 )(N x ) are (1j) (1j) wherein R 18 and R 19 are each independently H. This specific example can be used in combination with other specific examples of Ar 1 , Het , L 1 , Ar 2 , R 15 , Q 1 , and L 2 .

在另一個具體例中，…(A) Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(B)       Het 為(1b) (1b) ， 其中R6 係選自於下列所構成的群組之取代基：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(C) L1 係選自於下列所構成的群組 (1c) ， (1d) ， 以及 (1e) ， 其中R7 、R8 、R9 及R10 係各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基，以及(C2 -C6 )炔基；(D)       Ar2 為(1f) (1f) ， 其中：(1) X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 、 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(E) R15 係選自於下列所構成的群組：H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、C(O)-NRx Ry 、C(O)-苯基、(C1 -C4 )烷基-NRx Ry 、C(O)O-(C1 -C4 )烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基，以及(C1 -C4 )烷基-OC(=O)O-(C1 -C4 )烷基， 其中每個烷基、環烷基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(F) Q1 係選自於O及S所構成的群組；(G)Q2 係選自於O及S所構成的群組；(H) R16 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基)、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(I) R17 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(J) L2 係選自於下列所構成的群組 (1g) 及 (1h) ， 其中R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)；(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組： (1i) 及 (1j) ， 其中R18 及R19 係各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2、側氧、硫酮基、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(L) Rx 及Ry 係各自獨立地選自於下列所構成的群組：H、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基，以及苯基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(M)      (Het-1) 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，及苯氧基；以及(N) n 每一者係獨立地為0、1或2。In another specific example, (A) Ar 1 is (1a) (. 1A), wherein: (1) X 1 in the group selected from N and C R 1 constituted, and (2) R 1, R 2 , R 3, R 4 and R 5 are each independently selected from Groups consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 ) Cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 - C 4 ) haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O) -(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O- (C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, each of which Alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, phenyl, and phenoxy May be selectively one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkoxy , (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C (O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C (O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkane , (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-( C 1 -C 4 )alkyl, phenyl, and phenoxy; (B) Het is (1b) (1b), wherein R 6 is selected from from the group consisting of the following substituent groups: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkyl, (C 1 - C 4 ) haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl , (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O) -(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-( C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 - C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 ) An alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group, alkenyl group, alkynyl group, phenyl group, and phenoxy group are optional The ground is selected from one or more groups independently selected from the following Be a substituted group: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl, (C 3 -C 8) cycloalkyl (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n - (C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 ) Haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O- (C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3- C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 ) alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy; (C) L 1 Selected from the group consisting of the following (1c) , (1d) , and (1e), wherein R 7, R 8, R 9 and R 10 are each independently selected system from the group consisting of: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4 ) an alkyl group, a (C 1 -C 4 )haloalkyl group, a (C 3 -C 8 )cycloalkyl group, a (C 1 -C 4 )alkoxy group, a (C 1 -C 4 )halo alkoxy group, (C 2 -C 6 )alkenyl, and (C 2 -C 6 )alkynyl; (D) Ar 2 is (1f) (1F), wherein: (1) X 2 is selected from the group of the N and C R 13 constituted, and (2) R 11, R 12 , R 13, and R 14 are each independently selected from the following Groups formed: H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkane , (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 Haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-( C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 - C 4 ) alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkyl group , haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, phenyl, and phenoxy The group may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 ) Alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl , OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl , C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl , C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 Alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O) O-(C 1 -C 4 )alkyl, phenyl, and phenoxy; (E) R 15 is selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 3- C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 ) Alkyl, C(O)-NR x R y , C(O)-phenyl, (C 1 -C 4 )alkyl-NR x R y , C(O)O-(C 1 -C 4 ) alkane a group, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC ( O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, and (C 1 -C 4 )alkyl- OC(=O)O-(C 1 -C 4 )alkyl, wherein each alkyl, cycloalkyl, alkenyl, alkynyl, and phenyl group may be optionally independently selected from one or more Substituted in the following group of substituents: H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C 4 )alkyl, (C 1 -C 4 )halane , C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 ) alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl , OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 ) alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O -(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)- (C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O)O-(C 1 - C 4 ) alkyl, phenyl, and phenoxy; (F) Q 1 is selected from the group consisting of O and S; (G) Q 2 is selected from the group consisting of O and S; (H) R 16 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 ) Alkenyl, (C 2 -C 6 )alkynyl, C(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O- Phenyl, C(O)-(Het-1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)- (C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-C(O)-( Het-1), (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (NR x R y )-C(O)OH, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-NR x R y ,(C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-C(O)-N (R x )(C 1 -C 4 )alkyl (N(R x )-C(O)O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 ) Alkyl-C(O)-(Het-1)-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3 - C 8 ) cycloalkyl, (C 1 -C 4 )alkyl-OC(O)-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 ) Alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl- S(O) n -(Het-1), and (C 1 -C 4 )alkyl-O-(Het-1), wherein each alkyl group, cycloalkyl group, alkenyl group, alkynyl group, phenyl group, And (Het-1) may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkane a group, (C 1 -C 4 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(=O) n -(C 1 -C 4 )alkyl, S(=O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H , C(O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O) -(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O- (C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl), phenyl, phenoxy, Si(( C 1 -C 4 )alkyl) 3 , S(=O) n -NR x R y , and (Het-1); (I) R 17 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, C(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 - C 4 )alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, C(O )-(Het-1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 ) Alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 Alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-C(O)-(Het-1), (C 1 -C 4 )alkyl-C(O)-N(R x (C 1 -C 4 )alkyl (NR x R y )-C(O)OH, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 ) Alkyl-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-N(R x )-C(O)O- (C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (N(R x )-C(O) O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 )alkyl-C(O)-(Het-1)-C(O)O-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkyl-OC(O)-(Het -1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl (C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl-S(O) n -(Het-1), and (C 1 -C 4 )alkyl -O-(Het-1), wherein each alkyl group, cycloalkyl group, alkenyl group, alkynyl group, phenyl group, and (Het-1) may be optionally selected from one or more independently selected from the following The substituents of the group formed are substituted: H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )halane , (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(=O) n -(C 1 -C 4 )alkyl, S(=O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 ) haloalkyl, C(O)H, C(O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 - C 4 ) haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 ) alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 ) Alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, Phenyl, phenoxy, Si((C 1 -C 4 )alkyl) 3 , S(=O) n -NR x R y , and (Het-1); (J) L 2 selected From the following group (1g) and (1h), wherein R 20, R 21, R 22 , R 23 and R 24 are each independently selected from the group consisting of: H, F, Cl, Br , I, CN, NO 2, NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -( C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C (O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C( O) O-(C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, O-(C 1 -C 4 )alkyl, S-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, phenoxy, and (Het-1), wherein each alkyl, cycloalkyl, alkenyl, The phenyl, and (Het-1) substituents may be optionally selected from one or more independently selected from the following Substituted substituents are substituted: H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 ) alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl , OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O) -(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-( C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, O-(C 1 -C 4 )alkyl, S-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl , phenyl, phenoxy, and (Het-1); (K) R 16 and R 17 together with C x (Q 2 )(N x ) are selected from the group consisting of: (1i) and (1J), wherein R 18 and R 19 are each independently system selected from the group consisting of the following: H, F, Cl, Br , I, CN, NO2, oxygen side, thione group, (C 1 -C 4 ) an alkyl group, a (C 1 -C 4 )haloalkyl group, a (C 3 -C 8 )cycloalkyl group, a (C 1 -C 4 )alkoxy group, a (C 1 -C 4 )halo alkoxy group, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )halide Alkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-(C 1 -C 4 )alkyl , C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C( O) O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and (Het- 1); (L) R x and R y are each independently selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C) 3- C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 ) alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 ) Alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 Alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 ) ring Alkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C (O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, and phenyl, wherein each alkyl, haloalkyl, cycloalkyl, alkoxy The group, haloalkoxy, alkenyl, alkynyl, and phenyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br. , I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S (O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 ) haloalkyl, C(O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)- (C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O- (C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 ) alkane --O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 ) alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and (Het-1); (M) (Het-1) is 5 or 6 members, saturated or unsaturated a heterocyclic ring containing one or more heteroatoms independently selected from nitrogen, sulfur or oxygen, wherein each heterocyclic ring may be optionally substituted with one or more groups independently selected from the group consisting of Substituents: H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 ) Cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 - C 4) haloalkyl, C (O) -NR x R y, (C 1 -C 4) Group -NR x R y, C (O ) - (C 1 -C 4) alkyl, C (O) O- (C 1 -C 4) alkyl, C (O) - (C 1 -C 4) Haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 ) Cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C( O) O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl group The phenyl, and phenoxy substituents may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO. 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -( C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl , C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C( O) O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy And (N) n are each independently 0, 1, or 2.

在另一個具體例中，(A) Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、Cl、(C1 -C4 )鹵烷基及(C1 -C4 )鹵烷氧基；(B)       Het 為(1b) (1b) ， 其中，R6 為H；(C) L1 係選自於下列所構成的群組 (1c) ， (1d) ， 及 (1e) ， 其中，每個R7 、R8 、R9 及R10 係獨立地選自於H及(C1 -C4 )烷基所構成的群組；(D)       Ar2 為(1f) (1f) ， 其中：(1) X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C1 -C4 )烷氧基，以及C(O)O-(C1 -C4 )烷基；(E)R15 為H；(F) Q1 為O；(G)Q2 為S；(H)R16 為(K) ；(I)R17 為(K) ；(J) L2 係選自於下列所構成的群組 (1g) 及 (1h) ， 其中R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基，以及(C1 -C4 )烷基-O-(C1 -C4 )烷基；以及(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組： (1i) 及 (1j) ， 其中R18 及R19 各自為H。In another specific example, (A) Ar 1 is (1a) (. 1A), wherein: (1) X 1 in the group selected from N and C R 1 constituted, and (2) R 1, R 2 , R 3, R 4 and R 5 are each independently selected from The following group is composed of: H, Cl, (C 1 -C 4 )haloalkyl and (C 1 -C 4 )haloalkoxy; (B) Het is (1b) (1b) , wherein R 6 is H; (C) L 1 is selected from the group consisting of (1c) , (1d) , and (1E), wherein each R 7, R 8, R 9 and R 10 are independently selected from the group H and (C 1 -C 4) alkyl group composed; (D) Ar 2 is (1f ) (1F), wherein: (1) X 2 is selected from the group of the N and C R 13 constituted, and (2) R 11, R 12 , R 13 and R 14 are each independently selected from the group consisting of the following Group of: H, F, Cl, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, and C(O)O-( C 1 -C 4 )alkyl; (E) R 15 is H; (F) Q 1 is O; (G) Q 2 is S; (H) R 16 is (K) ; (I) R 17 is ( K) ; (J) L 2 is selected from the group consisting of (1g) and (1h), wherein R 20, R 21, R 22 , R 23 and R 24 are each independently selected from the group consisting of the following: H, F, Cl, ( C 1 -C 4) -alkyl, (C 1- C 4 ) haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, and (C 1 -C 4 An alkyl-O-(C 1 -C 4 )alkyl group; and (K) R 16 and R 17 together with C x (Q 2 )(N x ) are selected from the group consisting of: (1i) and (1j), wherein R 18 and R 19 are each H.

在另一個具體例中，(A) Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、Cl、CF3 及OCF3 ；(B)       Het 為(1b) (1b) ， 其中，R6 為H；(C) L1 係選自於下列所構成的群組 (1c) ， (1d) ， 及 (1e) ， 其中，每個R7 、R8 、R9 及R10 係獨立地選自於H及CH3 所構成的群組；(D)       Ar2 為(1f) (1f) ， 其中：(1) X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、CH3 、CF3 、OCH3 ，以及C(O)O-CH3 ；(E)R15 為H；(F) Q1 為O；(G)Q2 為S；(H)R16 為(K) ；(I)R17 為(K) ；(J) L2 係選自於下列所構成的群組 (1g) 及 (1h) ， 其中，R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、CH3 、CH2 CH2 CH3 、CH(CH3 )2 、CF3 、環丙基、OCH3 、OCH2 CH3 、OCH(CH3 )2 、OC(CH3 )3 、OCH(CH3 )CH2 CH3 、OCF3 、OCH2 CF3 、CH2 OCH3 ，及CH(CH3 )OCH3 ；以及(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組： (1i) 及 (1j) ， 其中R18 及R19 各自為H。式1 分子之製備 In another specific example, (A) Ar 1 is (1a) (. 1A), wherein: (1) X 1 in the group selected from N and C R 1 constituted, and (2) R 1, R 2 , R 3, R 4 and R 5 are each independently selected from The following groups are composed: H, Cl, CF 3 and OCF 3 ; (B) Het is (1b) (1b) , wherein R 6 is H; (C) L 1 is selected from the group consisting of (1c) , (1d) , and (1E), wherein each R 7, R 8, R 9 and R 10 are independently selected from the group H and CH 3 constituted; (D) Ar 2 is (1f) (1F), wherein: (1) X 2 is selected from the group of the N and C R 13 constituted, and (2) R 11, R 12 , R 13 and R 14 are each independently selected from the group consisting of the following Groups: H, F, Cl, CH 3 , CF 3 , OCH 3 , and C(O)O-CH 3 ; (E) R 15 is H; (F) Q 1 is O; (G) Q 2 Is S; (H) R 16 is (K) ; (I) R 17 is (K) ; (J) L 2 is selected from the group consisting of (1g) and (1h), wherein, R 20, R 21, R 22, R 23 and R 24 are each independently selected from the group consisting of: H, F, Cl, CH 3, CH 2 CH 2 CH 3, CH (CH 3 ) 2 , CF 3 , cyclopropyl, OCH 3 , OCH 2 CH 3 , OCH(CH 3 ) 2 , OC(CH 3 ) 3 , OCH(CH 3 )CH 2 CH 3 , OCF 3 , OCH 2 CF 3 , CH 2 OCH 3 , and CH(CH 3 )OCH 3 ; and (K) R 16 and R 17 together with C x (Q 2 )(N x ) are selected from the group consisting of: (1i) and (1j), wherein R 18 and R 19 are each H. Formula 1 preparation

許多式1之分子可描述為二種或多種互變異構物形式，如當R16 及R17 為H時(流程圖TAU)。為了簡化流程圖，所有分子皆描繪為存在為單一互變異構物。任一與所有積極可得到的互變異構物皆包含於本式1之範疇中，且不應推斷為該分子皆存在有其畫出形式之互變異構物。流程圖TAU Many of the molecules of Formula 1 can be described as two or more tautomeric forms, such as when R 16 and R 17 are H (flowchart TAU). To simplify the flow diagram, all molecules are depicted as being present as a single tautomer. Any and all actively available tautomers are included within the scope of Formula 1, and it should not be inferred that the molecule is present in its depicted form of tautomer. Flow chart TAU

式1分子一般具有大約400道耳頓至大約1200道耳頓之分子量。異氰酸酯之製備 The molecule of Formula 1 typically has a molecular weight of from about 400 Daltons to about 1200 Daltons. Preparation of isocyanate

於本揭露內容之式1分子可以製備自相對應之異氰酸酯1-2 ，其中Ar1 、Het 、L1 ，及Ar2 係如先前所揭示。於一些情況中，此等異氰酸酯並未單離出，而是由適當的前驅物於原位產生，並直接用於製備式1分子。一種此等適當的前驅物為胺類1-1 ，其中Ar1 、Het 、L1 ，及Ar2 係如先前所揭示，胺類1-1 可轉化成異氰酸酯1-2 ，其係藉由使用數種一般試劑如光氣、二光氣或三光氣之一者，於混合溶劑系統中，如二氯甲烷與水或是二乙基醚與水，於一種鹼如碳酸氫鈉或三乙基胺存在下，在溫度大約-10 ℃至大約50 ℃下進行(流程圖1，步驟a)。流程圖1 Molecules of Formula 1 of the present disclosure can be prepared from the corresponding isocyanates 1-2 wherein Ar 1 , Het , L 1 , and Ar 2 are as previously disclosed. In some cases, such isocyanates are not isolated, but are generated in situ by a suitable precursor and used directly to prepare the molecule of Formula 1. One such suitable precursor is amine 1-1 wherein Ar 1 , Het , L 1 , and Ar 2 are as previously disclosed, and amine 1-1 can be converted to isocyanate 1-2 by use. Several general reagents such as phosgene, diphosgene or triphosgene in a mixed solvent system such as dichloromethane and water or diethyl ether and water in a base such as sodium bicarbonate or triethyl The reaction is carried out at a temperature of from about -10 ° C to about 50 ° C in the presence of an amine (Scheme 1, step a). Flow chart 1

任擇地，異氰酸酯可經由醯疊氮1-4 之柯提斯重排反應(Curtius rearrangement)而產生，其中Ar1 、Het 、L1 及Ar2 係如先前所揭示，該醯疊氮繼而自對應的羧酸1-3 製備，其中Ar1 、Het 、L1 及Ar2 係如先前所揭示。醯疊氮1-4 可藉由以氯甲酸乙酯與疊氮鈉處理該酸，於胺基鹼如三乙基胺存在下而形成，或者以二苯基磷疊氮處理，在胺基鹼如三甲基胺存在下而形成(流程圖1，步驟b)。之後醯疊氮1-4 進行熱誘發的柯提斯重排反應，而產生對應之異氰酸酯1-2 。取決於特定的醯疊氮之特性，此種重排反應可於溶劑中，如甲苯、乙腈或醚類溶劑如二烷或四氫呋喃，在室溫下自發性地發生，或者可能需要加熱至40 ℃至約100 ℃。醯疊氮1-4 並非總是完全經鑑定出，但可不需鑑定直接加熱而生產異氰酸酯1-2 。線型縮二脲之製備 Optionally, the isocyanate can be produced via a Curtius rearrangement of 醯 azide 1-4 , wherein Ar 1 , Het , L 1 and Ar 2 are as previously disclosed, and the 醯 azide is followed by The corresponding carboxylic acids 1-3 were prepared wherein Ar 1 , Het , L 1 and Ar 2 were as previously disclosed. The azide 1-4 can be formed by treating the acid with ethyl chloroformate and sodium azide, in the presence of an amine base such as triethylamine, or with diphenylphosphorus azide in an amine base. Formed in the presence of trimethylamine (Scheme 1, step b). The helium azide 1-4 is then subjected to a thermally induced Curtis rearrangement reaction to produce the corresponding isocyanate 1-2 . Depending on the nature of the particular hydrazine, this rearrangement reaction can be carried out in a solvent such as toluene, acetonitrile or an ether solvent such as The alkane or tetrahydrofuran occurs spontaneously at room temperature or may require heating to a temperature of from 40 °C to about 100 °C. The azide 1-4 is not always fully identified, but isocyanate 1-2 can be produced without the need to identify direct heating. Preparation of linear biuret

異氰酸酯1-2 可以直接以脲2-1 予以處理，其中Q2 及L2 係如先前所揭示，於大約0.1當量至大約2當量之無機鹼，如碳酸銫或氫化鈉之存在下，產生縮二脲2-2 ，其中Ar1 、Het 、L1 、Ar2 、Q2 及L2 係如先前所揭示(流程圖2，步驟a)。反應可以於大約0 ℃至大約100 ℃的溫度下進行，較佳為大約20 ℃至大約80 ℃，於非質子溶劑或溶劑混合物中，其選自於乙腈、丙酮、甲苯、四氫呋喃、二氯乙烷、二氯甲烷或其混合物，但較佳使用乙腈。流程圖2 經取代的線型縮二脲之製備 Isocyanate 1-2 can be treated directly with urea 2-1 , wherein Q 2 and L 2 are as disclosed previously, in the presence of from about 0.1 equivalents to about 2 equivalents of an inorganic base such as cesium carbonate or sodium hydride. Diurea 2-2 , wherein Ar 1 , Het , L 1 , Ar 2 , Q 2 and L 2 are as previously disclosed (Scheme 2, step a). The reaction can be carried out at a temperature of from about 0 ° C to about 100 ° C, preferably from about 20 ° C to about 80 ° C, in an aprotic solvent or solvent mixture selected from the group consisting of acetonitrile, acetone, toluene, tetrahydrofuran, and dichloroethane. Alkane, dichloromethane or a mixture thereof, but acetonitrile is preferably used. Flow chart 2 Preparation of substituted linear biuret

線型縮二脲2-2 可以用R16 - 鹵 予以處理，其中R16 係如先前所揭示，於質子溶劑如乙醇中，於鹼如醋酸鈉存在下，於溫度約0 ℃至大約60 º℃下進行，以產出經取代的線型縮二脲3-1 ，其中Ar1 、Het 、L1 、Ar2 、Q2 、R16 及L2 係如先前所揭示(流程圖3，步驟a)。流程圖3 環狀縮二脲之製備 Biuret line 2-2 R 16 can - be treated halo, wherein, as previously disclosed, in a protic solvent such as ethanol, based on a base, such as sodium acetate, R 16 is present, at a temperature from about 0 ℃ to about 60 º ℃ Performing below to produce a substituted linear biuret 3-1 wherein Ar 1 , Het , L 1 , Ar 2 , Q 2 , R 16 and L 2 are as previously disclosed (Scheme 3, step a) . Flow chart 3 Preparation of cyclic biuret

原位產生之線型縮二脲2-2 可以不需純化直接轉化為各種環化的類似物(流程圖4)，或是其等可在環化之前自反應介質中單離出。環化可藉由以α-鹵化酯如溴乙酸甲酯處理，以形成2-亞胺基 1,3-硫族唑啉-4-酮4-1 (2-imino 1,3-chalcogenazolin-4-ones4-1 )，其中Ar1 、Het 、L1 、Ar2 、Q2 、R18 、R19 及L2 係如先前所揭示(流程圖4，步驟a)；以鄰二鹵化物如1-溴-2-氯乙烷或1,2-二氯乙烷處理，以形成2-亞胺基-1,3-硫族唑啉(2-imino-1,3-chalogenazolines)4-2 ，其中Ar1 、Het 、L1 、Ar2 、Q2 、R18 、R19 及L2 係如先前所揭示(流程圖4，步驟b)；以α-鹵化酮如氯化丙酮處理，以形成2-亞胺基-1,3-硫族唑酮(2-imino-1,3-chalcogenazoles)4-3 ，其中Ar1 、Het 、L1 、Ar2 、Q2 、R18 、R19 及L2 係如先前所揭示(流程圖4，步驟c)；1,3-二鹵丙烷如1-溴-3-氯-丙烷，以形成2-亞胺基-1,3-硫族哌啶(2-imino-1,3-chalcogenazinanes)4-4 ，其中Ar1 、Het 、L1 、Ar2 、Q2 、R18 、R19 及L2 係如先前所揭示(流程圖4，步驟d)；或是α,β-不飽和醯氯，如丙烯醯氯來處理，以形成2-亞胺基-1,3-硫族酮(2-imino-1,3-chalcogenazinones)4-5 ，其中Ar1 、Het 、L1 、Ar2 、Q2 、R18 、R19 及L2 係如先前所揭示(流程圖4，步驟e)。在流程圖3的步驟a中，較佳使用醋酸鈉，於質子溶劑如乙醇或甲醇中，於溫度範圍大約20 ℃至大約70 º℃下進行。在流程圖3的步驟b中，較佳使用無機鹼如碳酸鉀，於溶劑如乙腈或(較佳)2-丁酮中，於大約0 ℃至大約80 ℃之間的溫度下進行。流程圖4 The in situ generated linear biuret 2-2 can be directly converted to various cyclized analogs without purification (Scheme 4), or it can be isolated from the reaction medium prior to cyclization. Cyclization can be carried out by treatment with an α-halogenated ester such as methyl bromoacetate to form 2-imino1,3-1,3-oxazolin-4-one 4-1 (2-imino 1,3-chalcogenazolin-4) -ones 4-1 ), wherein Ar 1 , Het , L 1 , Ar 2 , Q 2 , R 18 , R 19 and L 2 are as previously disclosed (Scheme 4, step a); with o-dihalides such as Treatment with 1-bromo-2-chloroethane or 1,2-dichloroethane to form 2-imino-1,3-chalogenazolines 4-2 Wherein Ar 1 , Het , L 1 , Ar 2 , Q 2 , R 18 , R 19 and L 2 are as previously disclosed (Scheme 4, step b); treated with an α-halogenated ketone such as chlorinated acetone, Form 2-imino-1,3-chalcogenazoles 4-3 wherein Ar 1 , Het , L 1 , Ar 2 , Q 2 , R 18 , R 19 And L 2 is as previously disclosed (Scheme 4, step c); 1,3-dihalopropane such as 1-bromo-3-chloro-propane to form 2-imino-1,3-thiol 2-(imino-1,3-chalcogenazinanes) 4-4 , wherein Ar 1 , Het , L 1 , Ar 2 , Q 2 , R 18 , R 19 and L 2 are as previously disclosed (flowchart 4, steps) d); or α,β-unsaturated ruthenium chloride, such as propylene ruthenium chloride To form 2-imino-1,3-thio Ketone (2-imino-1,3-chalcogenazinones) 4-5 wherein Ar 1 , Het , L 1 , Ar 2 , Q 2 , R 18 , R 19 and L 2 are as previously disclosed (Scheme 4, Steps) e). In step a of Scheme 3, sodium acetate is preferably used in a protic solvent such as ethanol or methanol at a temperature ranging from about 20 ° C to about 70 ° C. In step b of Scheme 3, it is preferred to use an inorganic base such as potassium carbonate in a solvent such as acetonitrile or (preferably) 2-butanone at a temperature between about 0 ° C and about 80 ° C. Flow chart 4

流程圖5中描述環狀縮二脲之另一製備方法。2-亞胺基-1,3-硫族雜環(2-Imino-1,3-chalcogenazoheterocycles)5-1 ，其中Q2 Cx Nx 、R16 、R17 及L2 係如先前所揭示，可以於沒有鹼的情況下或是存在大約0.1當量至大約2當量之無機鹼，如碳酸銫或氫化鈉之下，直接與異氰酸酯1-2 反應，以形成環狀硫代縮二脲5-2 ，其中Ar1 、Het 、L1 、Ar2 、Q2 、R16 、R17 及L2 係如先前所揭示(流程圖5，步驟a)。反應可以於溫度大約0 ℃至大約100 ℃下進行，較佳為大約20 ℃至大約80 ℃，於非質子溶劑或溶劑混合物中，其選自於乙腈、丙酮、甲苯、四氫呋喃、1,2-二氯乙烷、二氯甲烷或其混合物，但較佳使用乙腈。環狀縮二脲4-1 、4-2 、4-3 、4-4 及4-5 ，其中L1 含有烯烴，可以於過渡金屬催化劑如附於碳上之鈀或氧化鉑(IV)存在下，藉由氫予以處理而還原。流程圖5 Another method of preparing cyclic biuret is described in Scheme 5. 2-Imino-1,3-chalcogenazoheterocycles 5-1 , wherein Q 2 C x N x , R 16 , R 17 and L 2 are as previously disclosed It can be directly reacted with isocyanate 1-2 in the absence of a base or in the presence of from about 0.1 equivalent to about 2 equivalents of an inorganic base such as cesium carbonate or sodium hydride to form a cyclic thiobiuret 5- 2 wherein Ar 1 , Het , L 1 , Ar 2 , Q 2 , R 16 , R 17 and L 2 are as previously disclosed (Scheme 5, step a). The reaction can be carried out at a temperature of from about 0 ° C to about 100 ° C, preferably from about 20 ° C to about 80 ° C, in an aprotic solvent or solvent mixture selected from the group consisting of acetonitrile, acetone, toluene, tetrahydrofuran, 1,2- Dichloroethane, dichloromethane or a mixture thereof, but acetonitrile is preferably used. Cyclic biurets 4-1 , 4-2 , 4-3 , 4-4 and 4-5 wherein L 1 contains an olefin which may be present on a transition metal catalyst such as palladium or platinum (IV) attached to carbon The reduction is carried out by treatment with hydrogen. Flow chart 5

任擇地，2-亞胺基-1,3-硫族雜環(2-Imino-1,3-chalcogenazoheterocycles)5-1 ，可以4-硝基苯基氯甲酸酯反應，形成4-硝基苯基胺甲酸酯5-2 ，其中Q2 Cx Nx 、R16 、R17 及L2 係如先前所揭示(流程圖5，步驟b)。此反應之實施可以等莫耳量之2-亞胺基-1,3-硫族雜環(2-Imino-1,3-chalcogenazoheterocycles)5-1 與氯甲酸酯，於極性非質子溶劑，如四氫呋喃、二烷或乙腈中，於存在大約0.1當量至大約2當量之無機鹼，如碳酸銫或碳酸鉀下，較佳於大概室溫下進行。4-硝基苯基胺甲酸酯5-2 可自濾液過濾出且濃縮，或者4-硝基苯基胺甲酸酯5-2 可直接使用(流程圖5，步驟c)。以胺類1-1 來處理4-硝基苯基胺甲酸酯5-2 ，可產生環狀硫代縮二脲5-2 。步驟c之進行亦可於大約0.1當量至大約2當量，較佳大約1當量至大約1.2當量之無機鹼，如碳酸銫或碳酸鉀存在下，於大約0 ℃至大約100 ℃的溫度下進行，較佳於室溫下進行。環狀縮二脲5-2 ，其中L1 含有烯烴，可以於過渡金屬催化劑，如附於碳上之鈀或氧化鉑(IV)存在下，藉由氫予以處理而還原。流程圖6 Optionally, 2-imino-1,3-chalcogenazoheterocycles 5-1 can be reacted with 4-nitrophenyl chloroformate to form 4-nitrate Phenylamino carbamate 5-2 wherein Q 2 C x N x , R 16 , R 17 and L 2 are as previously disclosed (Scheme 5, step b). The reaction can be carried out in a molar amount of 2-imino-1,3-chalcogenazoheterocycles 5-1 with a chloroformate in a polar aprotic solvent. Such as tetrahydrofuran, two The alkane or acetonitrile is preferably present at about room temperature in the presence of from about 0.1 equivalents to about 2 equivalents of an inorganic base such as cesium carbonate or potassium carbonate. 4-Nitrophenylcarbamate 5-2 can be filtered from the filtrate and concentrated, or 4-nitrophenylcarbamate 5-2 can be used directly (Scheme 5, step c). Treatment of 4-nitrophenylcarbamate 5-2 with amine 1-1 produces cyclic thiobiuret 5-2 . Step c can also be carried out at a temperature of from about 0.1 to about 2 equivalents, preferably from about 1 equivalent to about 1.2 equivalents of an inorganic base, such as cesium carbonate or potassium carbonate, at a temperature of from about 0 ° C to about 100 ° C. It is preferably carried out at room temperature. Cyclic biuret 5-2, wherein L 1 contains an olefin, may be transition metal catalyst such as palladium or attached to platinum oxide (IV) on the presence of carbon, to be treated by hydrogen reduction. Flow chart 6

流程圖6中描述環狀縮二脲之另一製備方法。胺類1-1 可以與4-硝基苯基氯甲酸酯反應，形成4-硝基苯基胺甲酸酯6-1 ，其中Ar1 、Het 、L1 及Ar2 係如先前所揭示(流程圖6，步驟a)。此反應之實施可以等莫耳量之胺類1-1 與氯甲酸酯，於極性非質子溶劑，如四氫呋喃、二烷或乙腈中，於存在大約0.1當量至大約2當量之無機鹼，如碳酸銫或碳酸鉀下，較佳於大概室溫下進行。4-硝基苯基胺甲酸酯6-1 可自濾液過濾出且濃縮，或者4-硝基苯基胺甲酸酯6-1 可直接使用(流程圖6，步驟b)。以2-亞胺基-1,3-硫族雜環(2-Imino-1,3-chalcogenazoheterocycles)5-1 來處理4-硝基苯基胺甲酸酯6-1 ，可產生環狀硫代縮二脲5-2 。此反應之實施可以等莫耳量之硝基苯基胺甲酸酯6-1 與2-亞胺基-1,3-硫族雜環5-1 ，於極性非質子溶劑乙腈中，於大約0.1當量至大約2當量之無機鹼如碳酸銫或碳酸鉀下，以及大約2當量之有機鹼如N,N -二異丙基乙胺存在下，較佳於大概室溫下進行。環狀縮二脲5-2 ，其中L1 含有烯烴，可以於過渡金屬催化劑如附於碳上之鈀或氧化鉑(IV)存在下，藉由氫予以處理而還原。流程圖7 Another method of preparing cyclic biuret is described in Scheme 6. Amine 1-1 can be reacted with 4-nitrophenyl chloroformate to form 4-nitrophenylcarbamate 6-1 wherein Ar 1 , Het , L 1 and Ar 2 are as previously disclosed (Flowchart 6, step a). The reaction can be carried out in the presence of a molar amount of amines 1-1 and chloroformate in polar aprotic solvents such as tetrahydrofuran, The alkane or acetonitrile is preferably present at about room temperature in the presence of from about 0.1 equivalents to about 2 equivalents of an inorganic base such as cesium carbonate or potassium carbonate. 4-Nitrophenylcarbamate 6-1 can be filtered from the filtrate and concentrated, or 4-nitrophenylcarbamate 6-1 can be used directly (Scheme 6, step b). 2-imino-1,3-heterocycle chalcogen (2-Imino-1,3-chalcogenazoheterocycles ) 5-1 4-nitrophenyl processed 6-1 carbamate, cyclic sulfur may be generated Diuretic biuret 5-2 . The reaction can be carried out in a molar amount of nitrophenyl carbamate 6-1 and 2-imino-1,3-thioheterocyclic 5-1 in a polar aprotic solvent acetonitrile. From 0.1 equivalents to about 2 equivalents of an inorganic base such as cesium carbonate or potassium carbonate, and about 2 equivalents of an organic base such as N,N -diisopropylethylamine are preferably carried out at about room temperature. Cyclic biuret 5-2, wherein L 1 contains an olefin, may be attached to a transition metal catalyst such as palladium or platinum oxide to (IV) on the presence of carbon, to be treated by hydrogen reduction. Flow chart 7

流程圖7中描述環狀縮二脲之額外的製備方法。以2-亞胺基-1,3-硫族雜環5-1 來處理胺甲酸酯7-1 ，其中Ar1 、Het 、L1 及Ar2 係如先前所揭示，可產生環狀硫代縮二脲5-2 。此反應之實施可以於密封管中、在非質子溶劑例如甲苯內，於大約80 ℃至大約140 ℃的溫度下進行(流程圖7，步驟a)。環狀縮二脲5-2 ，其中L1 含有烯烴，可以於過渡金屬催化劑如附於碳上之鈀或氧化鉑(IV)存在下，藉由氫予以處理而還原。胺類之製備 An additional method of preparation of the cyclic biuret is described in Scheme 7. Carbamate 7-1 is treated with 2-imino-1,3-chalcogeneic 5-1 , wherein Ar 1 , Het , L 1 and Ar 2 are as disclosed previously, and cyclic sulphur can be produced Diuretic biuret 5-2 . This reaction can be carried out in a sealed tube in an aprotic solvent such as toluene at a temperature of from about 80 ° C to about 140 ° C (Scheme 7, step a). Cyclic biuret 5-2, wherein L 1 contains an olefin, may be attached to a transition metal catalyst such as palladium or platinum oxide to (IV) on the presence of carbon, to be treated by hydrogen reduction. Preparation of amines

流程圖8中描述式1分子之製備所需要的胺類1-1 之製備方法。烯烴8-1 ，其中L1 含有烯烴且Ar1 及Het 係如先前所揭示，可以用Ar2 -鹵 予以處理，其中鹵為Cl、Br或I且Ar2 係如先前所揭示，以一種鈀催化劑例如醋酸鈀(II)，及一種膦配位基例如三(鄰甲苯基)膦，於一種鹼諸如三乙胺存在下，在像是N,N -二甲基甲醯胺之適合的溶劑中，使用傳統或微波加熱，在大約50℃至大約120℃的溫度下，以形成胺甲酸酯7-1 (流程圖8，步驟a)。完成胺甲酸酯7-1 上之三級-丁氧基羰基基團之去保護可於酸性條件下，以強酸如氯化氫或三氟乙酸，之後以一種鹼如碳酸氫鈉或氫氧化鈉進行自由鹼化，以提供胺類1-1 (流程圖8，步驟b)。流程圖8 The preparation of the amine 1-1 required for the preparation of the molecule of the formula 1 is described in Scheme 8. Olefin 8-1 wherein L 1 contains an olefin and Ar 1 and Het are as previously disclosed, and may be treated with an Ar 2 -halide wherein the halogen is Cl, Br or I and the Ar 2 is as previously disclosed, with a palladium A suitable catalyst such as palladium (II) acetate, and a phosphine ligand such as tris(o-tolyl)phosphine in the presence of a base such as triethylamine in a solvent such as N,N -dimethylformamide Medium, using conventional or microwave heating, at a temperature of from about 50 ° C to about 120 ° C to form the carbamate 7-1 (Scheme 8, step a). Complete deprotection of the tertiary-butoxycarbonyl group on the carbamate 7-1 can be carried out under acidic conditions with a strong acid such as hydrogen chloride or trifluoroacetic acid followed by a base such as sodium bicarbonate or sodium hydroxide. Free alkalization to provide amines 1-1 (Scheme 8, step b). Flow chart 8

任擇地，烯烴8-1 ，其中L1 含有烯烴且Ar1 及Het 係如先前所揭示，可以用Ar2 -鹵 予以處理，其中鹵為Cl、Br或I且Ar2 係如先前所揭示，以一種鈀催化劑例如醋酸鈀(II)，及一種膦配位基例如三(鄰甲苯基)膦，於一種鹼諸如三乙胺存在下，在像是N,N -二甲基甲醯胺之適合的溶劑中，使用傳統或微波加熱，在大約50℃至大約120℃的溫度下，以形成硝基芳烴類8-2 ，其中Ar1 、Het 、L1 及Ar2 係如先前所揭示，(流程圖8，步驟c)或是胺類1-1 (流程圖8，步驟e)。硝基芳烴類8-2 可以於過渡金屬催化劑如附於碳上之鈀或氧化鉑(IV)存在下，藉由氫予以處理而還原成對應的胺類1-1 。同樣地，可以理解當L1 含有烯烴，會發生烯烴之同時減少(流程圖8，步驟d)。任擇地，硝基芳烴類8-2 可以於一種酸諸如乙酸的存在下，透過鋅粉之處理，而還原成對應的胺類1-1 。亦可以理解鋅粉及酸會留下呈現為未經還原的任何烯烴。Optional, the olefin 8-1, wherein L 1 contains an olefin-based Het and Ar 1 and as disclosed previously, may be Ar 2 - dealt halo, wherein halo is Cl, Br or I and Ar 2 as previously disclosed system a palladium catalyst such as palladium (II) acetate, and a phosphine ligand such as tris(o-tolyl)phosphine in the presence of a base such as triethylamine in the form of N,N -dimethylformamide In a suitable solvent, conventional or microwave heating is used at a temperature of from about 50 ° C to about 120 ° C to form nitroaromatics 8-2 wherein Ar 1 , Het , L 1 and Ar 2 are as previously disclosed. (Scheme 8, step c) or amine class 1-1 (flowchart 8, step e). The nitroaromatics 8-2 can be reduced to the corresponding amines 1-1 by treatment with hydrogen in the presence of a transition metal catalyst such as palladium or platinum (IV) attached to carbon. Likewise, it is understood that when L 1 comprising an olefin, the olefin may occur simultaneously of reduced (Scheme 8, step d). Optionally, the nitroaromatics 8-2 can be reduced to the corresponding amines 1-1 by treatment with zinc powder in the presence of an acid such as acetic acid. It is also understood that zinc powder and acid will leave any olefins that appear to be unreduced.

流程圖9中描述式1分子之製備所需要的某些胺類9-4 之製備方法，其中Het 為1,2,4-三唑基且Ar1 、L1 及Ar2 係如先前所揭示。可從對應的羧酸製備的醯胺9-1 ，其中L1 及Ar2 係如先前所揭示，可以用1,1-二甲氧基-N,N -二甲基甲胺，在大約60 ℃至大約100 ℃的溫度下，予以處理以形成二甲胺)亞甲基加成物。該加成物可以在大約80 ℃至大約120 ℃的溫度下，於一種酸諸如乙酸的存在下，用水合肼予以處理，接著冷卻且用以一種鹼如氫氧化鈉予以中和，以提供硝基三唑9-2 ，其中L1 及Ar2 係如先前所揭示(流程圖9，步驟b)。硝基三唑9-2 可以用Ar1 -鹵 予以處理，其中鹵為Cl、Br或I且Ar1 係如先前所揭示，以一種銅催化劑例如氯化銅(I)、溴化銅(II)或碘化銅(I)，及一種配位基例如N 1,N 2-二甲基乙烷-1,2-二胺，於一種鹼諸如碳酸鉀存在下，在像是N,N -二甲基甲醯胺之適合的溶劑中，使用傳統或微波加熱，在大約50℃至大約120℃的溫度下進行，以形成硝基芳烴類9-3 ，其中Het 為1,2,4-三唑基且Ar1 、L1 及Ar2 係如先前所揭示(流程圖9，步驟c)。硝基芳烴類9-3 可以於過渡金屬催化劑如附於碳上之鈀或氧化鉑(IV)存在下，藉由氫予以處理而還原成對應的胺類9-4 。同樣地，可以理解當L1 含有烯烴，會發生烯烴之同時減少(流程圖9，步驟d)。任擇地，硝基芳烴類9-3 可以於一種酸諸如乙酸的存在下，透過鋅粉之處理，而還原成對應的胺類9-4 。亦可以理解鋅粉及酸會留下呈現為未經還原的任何烯烴。流程圖9 烯烴8-1 之製備 A process for the preparation of certain amines 9-4 required for the preparation of the molecule of formula 1 is depicted in Scheme 9, wherein Het is 1,2,4-triazolyl and Ar 1 , L 1 and Ar 2 are as previously disclosed . Amides may be prepared from the corresponding carboxylic acid 9-1, wherein L 1 and Ar 2 as previously disclosed system can be used 1,1-dimethoxy - N, N - dimethylmethanamine, at about 60 It is treated to form a dimethylamine)methylene adduct at a temperature of from °C to about 100 °C. The adduct may be treated with hydrazine hydrate in the presence of an acid such as acetic acid at a temperature of from about 80 ° C to about 120 ° C, followed by cooling and neutralization with a base such as sodium hydroxide to provide nitrate The triazole 9-2 , wherein L 1 and Ar 2 are as previously disclosed (Scheme 9, step b). 9-2 can nitrotriazole Ar 1 - dealt halo, wherein halo is Cl, Br or I and Ar 1 lines as previously disclosed, in a copper catalyst such as copper (I) chloride, copper (II Or copper (I) iodide, and a ligand such as N 1, N 2 -dimethylethane-1,2-diamine, in the presence of a base such as potassium carbonate, such as N, N - A suitable solvent for dimethylformamide is carried out using conventional or microwave heating at a temperature of from about 50 ° C to about 120 ° C to form nitroaromatic hydrocarbons 9-3 wherein Het is 1,2,4- Triazolyl and Ar 1 , L 1 and Ar 2 are as previously disclosed (Scheme 9, step c). The nitroaromatics 9-3 can be reduced to the corresponding amines 9-4 by treatment with hydrogen in the presence of a transition metal catalyst such as palladium or platinum (IV) attached to carbon. Likewise, it is understood that when L 1 comprising an olefin, the olefin may occur simultaneously of reduced (Scheme 9, step d). Optionally, the nitroarene 9-3 can be reduced to the corresponding amine 9-4 by treatment with zinc powder in the presence of an acid such as acetic acid. It is also understood that zinc powder and acid will leave any olefins that appear to be unreduced. Flow chart 9 Preparation of olefin 8-1

流程圖10中描述胺類1-1 之製備所需要的胺類8-1 之製備方法。芳基鹵化物10-1 ，其中鹵 為Cl、Br或I且Ar1 係如先前所揭示，可以用雜芳基鹵化物10-2 予以處理，其中鹵 為Cl、Br或I且Het 係如先前所揭示，以一種銅催化劑例如氯化銅(I)、溴化銅(II)或碘化銅(I)，於一種鹼諸如碳酸銫存在下，在像是N,N -二甲基甲醯胺之適合的溶劑中，使用傳統或微波加熱，在大約50 ℃至大約120 ℃的溫度下進行，以形成雜芳基鹵化物10-3 ，其中Ar1 、Het 及鹵 係如先前所揭示(流程圖9，步驟a)。以一種活性乙烯基來源，例如4,4,5,5-四甲基-2-乙烯基-1,3,2-二戊硼烷，於過渡金屬催化劑如雙(三苯基膦)二氯化鈀(II)之存在下，以一種鹼諸如碳酸鉀，在像是N,N -二甲基甲醯胺之極性溶劑中，使用傳統或微波加熱，在大約50 ℃至大約120 ℃的溫度下，來處理雜芳基鹵化物10-3 ，以形成烯烴8-1 (流程圖9，步驟b)。任擇地，雜芳基鹵化物10-3 可以用一種活性乙烯基來源，例如三丁基(乙烯基)錫烷，於過渡金屬催化劑如雙(三苯基膦)二氯化鈀(II)之存在下，在像是1,2-二氯乙烷之極性溶劑中，使用傳統或微波加熱，在大約50 ℃至大約120 ℃的溫度下，予以處理以形成烯烴8-1 (流程圖9，步驟b)。流程圖10 2- 亞胺基-1,3- 硫族雜環 之製備 The method of preparation of amines 8-1 Preparation of amine 1-1 as described in the flowcharts of need. Aryl halide 10-1 wherein the halide is Cl, Br or I and Ar 1 is as previously disclosed and may be treated with a heteroaryl halide 10-2 wherein the halide is Cl, Br or I and the Het is As previously disclosed, a copper catalyst such as copper (I) chloride, copper (II) bromide or copper (I) iodide is present in the presence of a base such as cesium carbonate, such as N,N -dimethyl Suitable solvents for the indoleamine, using conventional or microwave heating, are carried out at a temperature of from about 50 ° C to about 120 ° C to form a heteroaryl halide 10-3 wherein Ar 1 , Het and the halogen are as previously disclosed (Flowchart 9, step a). As an active vinyl source, such as 4,4,5,5-tetramethyl-2-vinyl-1,3,2-di Pentaborane, in the presence of a transition metal catalyst such as bis(triphenylphosphine)palladium(II) chloride, with a base such as potassium carbonate in a polar solvent such as N,N -dimethylformamide The heteroaryl halide 10-3 is treated with conventional or microwave heating at a temperature of from about 50 ° C to about 120 ° C to form the olefin 8-1 (Scheme 9, step b). Optionally, the heteroaryl halide 10-3 can be derived from a reactive vinyl source such as tributyl(vinyl)stannane over a transition metal catalyst such as bis(triphenylphosphine)palladium(II) chloride. In the presence of a solvent such as 1,2-dichloroethane, using conventional or microwave heating, at a temperature of from about 50 ° C to about 120 ° C, to form an olefin 8-1 (flowchart 9) , step b). Scheme 10 Preparation of 2-amino-1,3-heterocycles of chalcogenide

流程圖11中描述式1分子之製備所需要的2-亞胺基-1,3-硫族雜環之製備方法。苯胺11-1 ，其中L2 係如先前所揭示，可以用氯乙醯氯予以處理，在一種鹼諸如碳酸氫鈉存在下，於極性非質子溶劑如乙酸乙酯中，在溫度大約-10 ℃至大約30 ℃下進行，以形成醯胺11-2 ，其中L2 係如先前所揭示(流程圖11，步驟a)。醯胺11-2 係用硫氰酸鉀予以處理，在一種鹼諸如碳酸銫存在下，於極性溶劑如丙酮中，在溫度大約50 ℃至大約75 ℃下進行，以形成2-亞胺基-1,3-硫族雜環11-3 ，其中L2 係如先前所揭示(流程圖11，步驟c)。流程圖11 The preparation of the 2-imino-1,3-chalcogeneic ring required for the preparation of the molecule of Formula 1 is described in Scheme 11. Aniline 11-1 , wherein L 2 is as previously disclosed, can be treated with chloroethion chloride in the presence of a base such as sodium bicarbonate in a polar aprotic solvent such as ethyl acetate at a temperature of about -10 ° C. It is carried out at about 30 ° C to form the indoleamine 11-2 , wherein the L 2 is as previously disclosed (Scheme 11, step a). The indoleamine 11-2 is treated with potassium thiocyanate in the presence of a base such as cesium carbonate in a polar solvent such as acetone at a temperature of from about 50 ° C to about 75 ° C to form a 2-imino group - The 1,3-chalcogenic heterocyclic ring 11-3 wherein L 2 is as previously disclosed (Scheme 11, step c). Flow chart 11

流程圖12中描述式1分子之製備所需要的2-亞胺基-1,3-硫族雜環12-4 之製備方法，其中L2 係如先前所揭示。硫脲12-1 ，其中L2 係如先前所揭示，可以用氯甲酸酯諸如氯甲酸乙酯予以處理，以形成硫脲12-2 ，其中L2 係如先前所揭示(流程圖12，步驟a)。硫脲12-2 可以進一步用氯乙醯氯予以處理，在一種鹼諸如碳酸銫存在下，於極性非質子溶劑如乙腈中，在溫度大約10 ℃至大約40 ℃下進行，以形成硫族雜環12-3 ，其中L2 係如先前所揭示(流程圖9，步驟a)。硫族雜環12-3 可以用一種鹼諸如氫氧化鈉予以處理，於極性非質子溶劑如乙醇中，在溫度大約40 ℃至大約90 ℃下進行，以形成2-亞胺基-1,3-硫族雜環12-4 (流程圖12，步驟c)。流程圖12 實施例 The process for the preparation of the 2-imino-1,3-chalcogenocyclic 12-4 required for the preparation of the molecule of Formula 1 is illustrated in Scheme 12, wherein the L 2 is as previously disclosed. Thiourea 12-1, wherein L 2 system as previously disclosed, can be used ethylchloroformate chloroformate such as processing, to form a thiourea 12-2, wherein L 2 The system (12 flowchart previously disclosed, Step a). Thiourea 12-2 can be further treated with chloroacetic chloride, in the presence of a base such as cesium carbonate in a polar aprotic solvent such as acetonitrile at a temperature of from about 10 ° C to about 40 ° C to form a chalcogen ring 12-3, wherein L 2 the system (Scheme 9, step a) previously disclosed. The chalcogenide heterocycle 12-3 can be treated with a base such as sodium hydroxide in a polar aprotic solvent such as ethanol at a temperature of from about 40 ° C to about 90 ° C to form 2-imino-1,3 - chalcogenide 12-4 (Scheme 12, step c). Flow chart 12 Example

此等實施例係為了說明之目的，而不應解釋為將本揭露內容限制為僅此等實施例中揭露的具體例。The examples are for illustrative purposes and are not to be construed as limiting the disclosure to the specific examples disclosed in the embodiments.

自商業來源獲得之起始原料、試劑及溶劑係未經進一步純化即使用。無水溶劑係購自Aldrich之Sure/Seal™，及以所收到的形式使用。熔點係在Thomas Hoover Unimelt毛細管熔點儀或是在Stanford Research Systems之OptiMelt自動化熔點系統上測得，及未經校正。使用「室溫」的實施例係在溫度範圍大約20 ℃至大約24 ℃的氣候控制實驗室中進行。分子係以其等依據ISIS Draw、ChemDraw或ACD Name Pro內的命名程式所命名之已知名稱顯示。若此等程式無法命名一分子，則此分子係依習用的命名規則來命名。除非另有說明，否則1 H NMR光譜數據係以ppm (δ)為單位及於300、400、500或600 MHz記錄；13 C NMR光譜數據係以ppm (δ)為單位及於75、100或150 MHz記錄，以及19 F NMR光譜數據係以ppm (δ)為單位及於376 MHz記錄。實施例1 ：甲基 2-[ 雙( 三級丁氧基羰基) 胺基]-5- 碘- 苯甲酸酯(C1) 之製備 The starting materials, reagents and solvents obtained from commercial sources were used without further purification. Anhydrous solvent was purchased from Sure/SealTM from Aldrich and used in the form received. Melting points were measured on a Thomas Hoover Unimelt capillary melting point apparatus or on an OptiMelt automated melting point system from Stanford Research Systems and uncorrected. Examples using "room temperature" are carried out in a climate control laboratory having a temperature range of from about 20 °C to about 24 °C. The molecular system is displayed with its known name, etc., named after the naming program in ISIS Draw, ChemDraw, or ACD Name Pro. If these programs cannot name a molecule, the molecule is named according to the naming conventions used. 1 H NMR spectral data is reported in ppm (δ) and at 300, 400, 500 or 600 MHz unless otherwise stated; 13 C NMR spectral data is in ppm (δ) and at 75, 100 or The 150 MHz record, as well as the 19 F NMR spectral data, were recorded in ppm (δ) and at 376 MHz. Example 1: [bis (three-butoxycarbonyl) amino] methyl 2-5-iodo - benzoic acid ester (C1) of

將甲基 2-胺基-5-碘苯甲酸酯(5.00g，18.1 mmol)及二-三級丁基二碳酸酯(di-tert-butyl dicarbonate) (3.94g，18.1 mmol)添加至圓底燒瓶中。將燒瓶密封且排氣/重新填充氮氣(3x)。添加四氫呋喃(90 mL)，且讓反應加熱至60 ℃過夜。添加4-二甲基胺基吡啶(1.10g，9.02 mmol)，且讓反應加熱歷時1.5小時。使反應冷卻至室溫。添加乙酸乙酯及水，以及將層予以分離。將有機層組合、於無水硫酸鈉上乾燥、過濾及濃縮。藉由急速管柱層析法予以純化，使用乙酸乙酯/己烷作為沖提液，提供如淡黃色固體之標題化合物(1.70g，20%)：1 H NMR (400 MHz, CDCl3 ) δ 8.32 (d,J = 2.1 Hz, 1H), 7.84 (dd,J = 8.3, 2.2 Hz, 1H), 6.93 (d,J = 8.3 Hz, 1H), 3.87 (s, 3H), 1.38 (s, 18H)；EIMSm/z 478 ([M+H]+ )。實施例2 ：2-(3- 溴-1H -1,2,4- 三唑-1- 基)-5-( 三氟甲氧基) 吡啶(C2) 之製備 Methyl 2-amino-5-iodobenzoate (5.00 g, 18.1 mmol) and di-tert-butyl dicarbonate (3.94 g, 18.1 mmol) were added to the circle. In the bottom flask. The flask was sealed and vented/refilled with nitrogen (3x). Tetrahydrofuran (90 mL) was added and the reaction was allowed to warm to 60 °C overnight. 4-Dimethylaminopyridine (1.10 g, 9.02 mmol) was added and the reaction was allowed to heat over 1.5 h. The reaction was allowed to cool to room temperature. Ethyl acetate and water were added and the layers were separated. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. Be purified by flash column chromatography using ethyl acetate / hexanes as eluent, to provide as a pale yellow solid of the title compound (1.70g, 20%): 1 H NMR (400 MHz, CDCl 3) δ 8.32 (d, J = 2.1 Hz, 1H), 7.84 (dd, J = 8.3, 2.2 Hz, 1H), 6.93 (d, J = 8.3 Hz, 1H), 3.87 (s, 3H), 1.38 (s, 18H ); EIMS m/z 478 ([M+H] + ). Example 2: Preparation of (3-bromo -1 H -1,2,4- triazol-1-yl) -5- (trifluoromethoxy) pyridine (C2) of 2-

將2-溴-5-(三氟甲氧基)吡啶(1.0g，4.1 mmol)及3-溴-1H -1,2,4-三唑(0.91g，6.2 mmol)添加至反應小瓶。添加N,N -二甲基甲醯胺(16 mL)及碳酸銫(2.6g，8.2 mmol)，以及小瓶用氬予以除氣5分鐘。添加碘化銅(I) (0.077g，0.41 mmol)，以及小瓶用氬予以進一步除氣5分鐘。將小瓶加蓋，以及於具有外部IR-感測器監測小瓶側的溫度之Biotage Initiator®微波反應器中，以100 ℃加熱歷時1小時。使反應混合物冷卻至室溫，倒至碎冰上(3倍體積)，以及用乙酸乙酯(3 x 150 mL)來萃取。組合的有機層係於硫酸鈉上乾燥、過濾及濃縮。藉由急速管柱層析法予以純化，其係使用0-40%乙酸乙酯/己烷作為沖提液，提供如淡棕色液體之標題化合物(0.40g，31%)：1 H NMR (400 MHz, CDCl3 ) δ 9.01 (s, 1H), 8.39 (d,J = 2.4 Hz, 1H), 7.94 (d,J = 8.8 Hz, 1H), 7.77 (dd,J = 1.6 Hz, 8.8Hz, 1H)；EIMSm/z 309 ([M+H]+ )。2-Bromo-5-(trifluoromethoxy)pyridine (1.0 g, 4.1 mmol) and 3-bromo-1 H -1,2,4-triazole (0.91 g, 6.2 mmol) were added to a reaction vial. N,N -dimethylformamide (16 mL) and cesium carbonate (2.6 g, 8.2 mmol) were added, and the vial was degassed with argon for 5 minutes. Copper (I) iodide (0.077 g, 0.41 mmol) was added and the vial was further degassed with argon for 5 minutes. The vial was capped and heated in a Biotage Initiator® microwave reactor with external IR-sensor monitoring of the vial side temperature for 1 hour at 100 °C. The reaction mixture was cooled to room temperature, poured onto EtOAc (3 EtOAc). The combined organic layers were dried over sodium sulfate, filtered and concentrated. It is purified by flash column chromatography, which is based 0-40% ethyl acetate / hexanes as eluent to provide the title as a pale brown liquid of the compound (0.40g, 31%): 1 H NMR (400 MHz, CDCl 3 ) δ 9.01 (s, 1H), 8.39 (d, J = 2.4 Hz, 1H), 7.94 (d, J = 8.8 Hz, 1H), 7.77 (dd, J = 1.6 Hz, 8.8Hz, 1H ); EIMS m/z 309 ([M+H] + ).

下列化合物係以實施例 2 中概述之流程相似的方式予以製備： 2-(3- 溴-1H -1,2,4- 三唑-1- 基)-3- 氯-5-( 三氟甲基) 吡啶 (C3) The following compounds were prepared in a similar manner to the procedure outlined in Example 2 : 2-(3- bromo-1 H -1,2,4- triazol-1 -yl)-3 -chloro-5-( trifluoro Methyl) pyridine (C3)

從3-氯2-碘-5-(三氟甲基)吡啶(0.750 g, 60%)製備：1 H NMR (300 MHz, CDCl3 ) δ 8.80 (s, 1H), 8.72 (s, 1H), 8.22 (s, 1H)；ESIMSm/z 327 ([M+H]+ )。實施例3 ：1-(4-( 三氟甲氧基) 苯基)-3- 乙烯基-1H -1,2,4- 三唑 (C4) 之製備 Prepared from 3-chloro-2-iodo-5-(trifluoromethyl)pyridine (0.750 g, 60%): 1 H NMR (300 MHz, CDCl 3 ) δ 8.80 (s, 1H), 8.72 (s, 1H) , 8.22 (s, 1H); ESIMS m/z 327 ([M+H] + ). Example 3: Preparation of 1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-vinyl (C4) of

將3-溴-1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑(0.200g，0.649 mmol)、4,4,5,5-四甲基-2-乙烯基-1,3,2-二戊硼烷(0.150g，0.974 mmol)、雙(三苯基膦)二氯化鈀(II)(0.0750g，0.0650 mmol)，及碳酸鉀(0.179g，1.30 mmol)配於N,N -二甲基甲醯胺/水(0.2 M，4:1)，添加至微波反應小瓶。將小瓶加蓋，以及於具有外部IR-感測器監測小瓶側的溫度之Biotage Initiator®微波反應器中，以90 ℃加熱歷時30分鐘。反應混合物係用乙酸乙酯來稀釋，以及用水來清洗。水層係以乙酸乙酯進一步萃取。將有機層組合、於無水硫酸鈉上乾燥、過濾及濃縮。藉由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷作為沖提液，提供如灰白色固體之標題化合物(0.115g，69%)：mp 89-91 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.47 (d,J = 0.7 Hz, 1H), 7.80 - 7.63 (m, 2H), 7.43 - 7.30 (m, 2H), 6.80 (ddd,J = 17.6, 11.0, 0.7 Hz, 1H), 6.35 (dd,J = 17.6, 1.5 Hz, 1H), 5.62 (dd,J = 11.0, 1.5 Hz, 1H)；19 F NMR (376 MHz, CDCl3 ) δ -58.04；13 C NMR (101 MHz, CDCl3 ) δ 162.74, 148.38, 141.21, 135.43, 126.09, 122.38, 121.65, 121.13, 120.90；EIMSm/z 255 ([M]+ )。3-Bromo-1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazole (0.200 g, 0.649 mmol), 4,4,5,5-tetramethyl Ke-2-vinyl-1,3,2-di Pentaborane (0.150 g, 0.974 mmol), bis(triphenylphosphine)palladium(II) chloride (0.0750 g, 0.0650 mmol), and potassium carbonate (0.179 g, 1.30 mmol) in N,N - II Methylformamide/water (0.2 M, 4:1) was added to the microwave reaction vial. The vial was capped and heated in a Biotage Initiator® microwave reactor with external IR-sensor monitoring of the vial side temperature for 30 minutes at 90 °C. The reaction mixture was diluted with ethyl acetate and washed with water. The aqueous layer was further extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. It is purified by flash column chromatography, which is based using ethyl acetate / hexanes as eluent to provide an off-white solid as the title compound (0.115g, 69%): mp 89-91 ℃; 1 H NMR ( 400 MHz, CDCl 3 ) δ 8.47 (d, J = 0.7 Hz, 1H), 7.80 - 7.63 (m, 2H), 7.43 - 7.30 (m, 2H), 6.80 (ddd, J = 17.6, 11.0, 0.7 Hz, 1H), 6.35 (dd, J = 17.6, 1.5 Hz, 1H), 5.62 (dd, J = 11.0, 1.5 Hz, 1H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.04; 13 C NMR (101 MHz, CDCl 3 ) δ 162.74, 148.38, 141.21, 135.43, 126.09, 122.38, 121.65, 121.13, 120.90; EIMS m/z 255 ([M] + ).

下列化合物係以實施例 3 中概述之流程相似的方式予以製備： 5-( 三氟甲氧基)-2-(3- 乙烯基-1H -1,2,4- 三唑-1- 基) 吡啶(C5) The following compounds were prepared in a similar manner to the procedure outlined in Example 3 : 5-( trifluoromethoxy)-2-(3- vinyl-1 H -1,2,4- triazol-1 -yl ) pyridine (C5)

從2-(3-溴-1H -1,2,4-三唑-1-基)-5-(三氟甲氧基)吡啶(C2) 及四(三苯基膦)鈀(0)製備(0.500g，61%)：1 H NMR (300 MHz, CDCl3 ) δ 9.06 (s, 1H), 8.39 (s, 1H), 7.93 – 7.96 (d,J = 9.6 Hz, 1H), 7.74 – 7.77 (d,J = 9.6 Hz, 1H), 6.78 (dd,J = 17.4, 10.8 Hz, 1H), 6.35 – 6.41 (d,J = 17.4 Hz, 1H), 5.62 – 5.66 (d,J = 10.8 Hz, 1H)；EIMS m/z 257 ([M+H]+ )。實施例4 ：3- 氯-5-( 三氟甲基)-2-(3- 乙烯基-1H -1,2,4- 三唑-1- 基) 吡啶(C6) 之製備 From 2-(3-bromo-1 H -1,2,4-triazol-1-yl)-5-(trifluoromethoxy)pyridine (C2) and tetrakis(triphenylphosphine)palladium(0) Preparation (0.500 g, 61%): 1 H NMR (300 MHz, CDCl 3 ) δ 9.06 (s, 1H), 8.39 (s, 1H), 7.93 - 7.96 (d, J = 9.6 Hz, 1H), 7.74 – 7.77 (d, J = 9.6 Hz, 1H), 6.78 (dd, J = 17.4, 10.8 Hz, 1H), 6.35 – 6.41 (d, J = 17.4 Hz, 1H), 5.62 – 5.66 (d, J = 10.8 Hz) , 1H); EIMS m/z 257 ([M+H] + ). Example 4: 3-chloro-5- (trifluoromethyl) -2- (3-vinyl-yl -1 H -1,2,4- triazol-1) pyridine (C6) of

將2-(3-溴-1H -1,2,4-三唑-1-基)-3-氯-5-(三氟甲基)吡啶(C3) (1.00g，3.06 mmol)、三丁基(乙烯基)錫烷(1.16g，3.66 mmol)，及1,2-二氯乙烷(25 mL)添加至微波反應小瓶。反應混合物用氬予以除氣15分鐘。添加雙(三苯基膦)二氯化鈀(II) (0.112g，0.153 mmol)，以及反應混合物用氬再次予以除氣5分鐘。將小瓶加蓋，以及於具有外部IR-感測器監測小瓶側的溫度之Biotage Initiator®微波反應器中，以100 ℃加熱反應歷時16小時。使反應混合物濃縮。藉由急速管柱層析法予以純化，提供標題化合物(0.650g，77%)：1 H NMR (300 MHz, CDCl3 ) δ 8.86 (s, 1H), 7.72 (s, 1H), 8.20 (s, 1H), 6.84 (dd,J = 17.4, 10.8 Hz, 1H), 6.41 (d,J = 17.4 Hz, 1H), 5.67 (d,J = 10.8 Hz, 1H)；ESIMSm/z 275 ([M+H]+ )。實施例5 ： 三 級 丁基 (E )-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 胺甲酸酯(C7) 之製備 2-(3-Bromo-1 H -1,2,4-triazol-1-yl)-3-chloro-5-(trifluoromethyl)pyridine (C3) (1.00 g, 3.06 mmol), three Butyl (vinyl)stannane (1.16 g, 3.66 mmol), and 1,2-dichloroethane (25 mL) were added to the microwave reaction vial. The reaction mixture was degassed with argon for 15 minutes. Bis(triphenylphosphine)palladium(II) chloride (0.112 g, 0.153 mmol) was added, and the reaction mixture was again degassed with argon for 5 min. The vial was capped and the reaction was heated at 100 °C for 16 hours in a Biotage Initiator® microwave reactor with external IR-sensor monitoring of the vial side temperature. The reaction mixture was concentrated. Be purified by flash column chromatography to provide the title compound (0.650g, 77%): 1 H NMR (300 MHz, CDCl 3) δ 8.86 (s, 1H), 7.72 (s, 1H), 8.20 (s , 1H), 6.84 (dd, J = 17.4, 10.8 Hz, 1H), 6.41 (d, J = 17.4 Hz, 1H), 5.67 (d, J = 10.8 Hz, 1H); ESIMS m/z 275 ([M +H] + ). Example 5: three-butyl (E) - (4- (2- (1- (4- ( trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl ) vinyl) phenyl) carbamate (C7) of

將1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) (0.0500g，0.196 mmol)、三級丁基(4-碘苯基)胺甲酸酯(0.125g，0.392 mmol)、醋酸鈀(II)(0.00440 mg，0.0200 mmol)，以及三(鄰甲苯基)膦(0.0119g，0.0390 mmol)，添加至微波反應小瓶。將小瓶密封且排氣/重新填充氮氣(3x)。添加N,N -二甲基甲醯胺(0.784 mL)，接著添加三乙胺(0.0273 mL，0.196 mmol)。小瓶係於具有外部IR-感測器監測小瓶側的溫度之Biotage Initiator®微波反應器中，以100 ℃加熱歷時30分鐘。使反應冷卻至室溫，用DCM來稀釋，以及用用水及鹽水清洗。使有機物乾燥、過濾以及濃縮。藉由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷作為沖提液，提供如灰白色固體之標題化合物(0.0860g，97%)：mp 171-173 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.50 (d,J = 0.7 Hz, 1H), 7.80 - 7.70 (m, 2H), 7.64 (d,J = 16.3 Hz, 1H), 7.55 - 7.47 (m, 2H), 7.43 - 7.33 (m, 4H), 7.06 (dd,J = 16.2, 0.7 Hz, 1H), 6.64 (s, 1H), 1.53 (s, 9H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03；ESIMSm/z 447 ([M+H]+ )。1-(4-(Trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) (0.0500 g, 0.196 mmol), tert-butyl (4) -iodophenyl)carbamate (0.125 g, 0.392 mmol), palladium(II) acetate (0.00440 mg, 0.0200 mmol), and tris(o-tolyl)phosphine (0.0119 g, 0.0390 mmol), added to microwave reaction Vial. The vial was sealed and vented/refilled with nitrogen (3x). N,N -dimethylformamide (0.784 mL) was added followed by triethylamine (0.0273 mL, 0.196 mmol). The vial was attached to a Biotage Initiator® microwave reactor with an external IR-sensor to monitor the temperature on the vial side and heated at 100 °C for 30 minutes. The reaction was allowed to cool to room temperature, diluted with DCM and washed with water and brine. The organics were dried, filtered and concentrated. The title compound (0.0860 g, 97%): mp 171-173 ° C; 1 H NMR ( 400 MHz, CDCl 3 ) δ 8.50 (d, J = 0.7 Hz, 1H), 7.80 - 7.70 (m, 2H), 7.64 (d, J = 16.3 Hz, 1H), 7.55 - 7.47 (m, 2H), 7.43 - 7.33 (m, 4H), 7.06 (dd, J = 16.2, 0.7 Hz, 1H), 6.64 (s, 1H), 1.53 (s, 9H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.03; ESIMS m/z 447 ([M+H] + ).

下列化合物係以實施例 5 中概述之流程相似的方式予以製備： 三 級 丁基 (E )-(3- 甲基-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 胺甲酸酯(C8) The following compound is to be prepared in the manner outlined in Example 5 In the process similar to Example: three-butyl (E) - (3- methyl-4- (2- (1- (4- (trifluoromethoxy) benzene -1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) carbamate (C8)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) 及三級丁基 (4-碘-3-甲基苯基)胺甲酸酯製備且單離為白色固體(0.600g，66%)：mp 199-201 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.50 (d,J = 0.7 Hz, 1H), 7.96 - 7.81 (m, 1H), 7.81 - 7.70 (m, 2H), 7.60 (d,J = 8.5 Hz, 1H), 7.43 - 7.33 (m, 2H), 7.28 (s, 1H), 7.19 (dd,J = 8.5, 2.3 Hz, 1H), 7.00 (dd,J = 16.1, 0.7 Hz, 1H), 6.48 (s, 1H), 2.47 (s, 3H), 1.53 (s, 9H)；19 F NMR (471 MHz, CDCl3 ) δ -58.03；13 C NMR (126 MHz, CDCl3 ) δ 163.36, 152.55, 148.27, 141.18, 138.52, 137.72, 135.50, 132.24, 129.94, 126.43, 122.41, 121.41, 121.01, 119.98, 119.36, 116.57, 116.26, 28.34, 20.14；ESIMSm/z 461 ([M+H]+ )。甲基 2-[ 雙( 三級丁氧基羰基) 胺基]-5-[(E )-2-[1-[4-( 三氟甲氧基) 苯基]-1,2,4- 三唑-3- 基] 乙烯基]- 苯甲酸酯(C9) From 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and tert-butyl (4-iodo-3-methyl) Phenyl)carbamate was prepared as a white solid (0.600 g, 66%): mp 199-201 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.50 (d, J = 0.7 Hz, 1H) , 7.96 - 7.81 (m, 1H), 7.81 - 7.70 (m, 2H), 7.60 (d, J = 8.5 Hz, 1H), 7.43 - 7.33 (m, 2H), 7.28 (s, 1H), 7.19 (dd , J = 8.5, 2.3 Hz, 1H), 7.00 (dd, J = 16.1, 0.7 Hz, 1H), 6.48 (s, 1H), 2.47 (s, 3H), 1.53 (s, 9H); 19 F NMR ( 471 MHz, CDCl 3 ) δ -58.03; 13 C NMR (126 MHz, CDCl 3 ) δ 163.36, 152.55, 148.27, 141.18, 138.52, 137.72, 135.50, 132.24, 129.94, 126.43, 122.41, 121.41, 121.01, 119.98, 119.36 , 116.57, 116.26, 28.34, 20.14; ESIMS m/z 461 ([M+H] + ). Methyl 2-[ bis( tertiarybutoxycarbonyl) amino]-5-[( E )-2-[1-[4-( trifluoromethoxy) phenyl]-1,2,4- Triazol-3 -yl] vinyl] -benzoate (C9)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) 及甲基 2-[雙(三級丁氧基羰基)胺基]-5-碘-苯甲酸酯(C1) 製備且單離為黃色固體(0.300g，78%)：mp 57-67 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.58 - 8.44 (m, 1H), 8.25 (dd,J = 18.8, 2.2 Hz, 1H), 7.89 - 7.62 (m, 4H), 7.39 (dq,J = 7.9, 0.9 Hz, 2H), 7.26 - 7.16 (m, 2H), 3.90 (d,J = 2.1 Hz, 3H), 1.40 (d,J = 6.9 Hz, 18H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03；ESIMSm/z 605 ([M+H]+ )。三 級 丁基 (E )-(2- 氯-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 胺甲酸酯(C10) From 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and methyl 2-[bis(tertiary-butoxycarbonyl) Prepared by amino]-5-iodo-benzoate (C1) and isolated as a yellow solid (0.300 g, 78%): mp 57-67 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.58 8.44 (m, 1H), 8.25 (dd, J = 18.8, 2.2 Hz, 1H), 7.89 - 7.62 (m, 4H), 7.39 (dq, J = 7.9, 0.9 Hz, 2H), 7.26 - 7.16 (m, 2H), 3.90 (d, J = 2.1 Hz, 3H), 1.40 (d, J = 6.9 Hz, 18H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.03; ESIMS m/z 605 ([M+ H] + ). Three-butyl (E) - (2- chloro-4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl ) vinyl) phenyl) carbamate (C10)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) 及三級丁基 (2-氯-4-碘苯基)胺甲酸酯製備且單離為黃色固體(0.515g，90%)：mp 160-173 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.52 - 8.43 (m, 1H), 8.21 (d,J = 8.6 Hz, 1H), 7.81 - 7.67 (m, 2H), 7.62 - 7.53 (m, 2H), 7.46 (dd,J = 8.6, 1.9 Hz, 1H), 7.42 - 7.33 (m, 2H), 7.14 - 7.00 (m, 2H), 1.55 (s, 9H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03；ESIMSm/z 481 ([M+H]+ )。三 級 丁基 (E )-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 丙-1- 烯-1- 基) 苯基) 胺甲酸酯(C11) From 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and tert-butyl (2-chloro-4-iodobenzene) Preparation of the carbamic acid ester and isolated as a yellow solid (0.515 g, 90%): mp 160-173 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.52 - 8.43 (m, 1H), 8.21 (d , J = 8.6 Hz, 1H), 7.81 - 7.67 (m, 2H), 7.62 - 7.53 (m, 2H), 7.46 (dd, J = 8.6, 1.9 Hz, 1H), 7.42 - 7.33 (m, 2H), 7.14 - 7.00 (m, 2H), 1.55 (s, 9H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.03; ESIMS m/z 481 ([M+H] + ). Three-butyl (E) - (4- (2- (1- (4- ( trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) propan -1 - en-1-yl) phenyl) carbamate (C11)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) 及三級丁基 (2-氯-4-碘苯基)胺甲酸酯製備且單離為橘色固體(0.330g，38%)： mp 199-201℃；1 H NMR (400 MHz, CDCl3 ) δ 8.02 (s, 1H), 7.83 – 7.66 (m, 1H), 7.53 – 7.45 (m, 1H), 7.46 – 7.28 (m, 3H), 6.55 (d,J = 11.0 Hz, 1H), 2.96 (s, 3H), 2.89 (d,J = 0.6 Hz, 3H), 2.42 (d,J = 1.4 Hz, 1H), 1.57 – 1.47 (m, 9H)；19 F NMR (376 MHz, CDCl3 ) δ -58.04；ESIMSm/z 461 ([M+H]+ )。三 級 丁基 (E )-(4-(2-(1-(5-( 三氟甲氧基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 胺甲酸酯(C12) From 1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-vinyl (C4) and tertiary butyl (2-chloro-4-iodobenzene The urethane was prepared and isolated as an orange solid (0.330 g, 38%): mp 199-201 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.02 (s, 1H), 7.83 - 7.66 ( m, 1H), 7.53 – 7.45 (m, 1H), 7.46 – 7.28 (m, 3H), 6.55 (d, J = 11.0 Hz, 1H), 2.96 (s, 3H), 2.89 (d, J = 0.6 Hz , 3H), 2.42 (d, J = 1.4 Hz, 1H), 1.57 – 1.47 (m, 9H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.04; ESIMS m/z 461 ([M+H] + ). Three-butyl (E) - (4- (2- (1- (5- ( trifluoromethoxy) pyridin-2-yl) -1 H -1,2,4- triazol-3-yl) Vinyl) phenyl) carbamate (C12)

從5-(三氟甲基)-2-(3-乙烯基-1H -1,2,4-三唑-1-基)吡啶(C5) 及三級丁基 (2-氯-4-碘苯基)胺甲酸酯製備(0.200g，23%)：ESIMSm/z 448 ([M+H]+ )。三 級 丁基 (E )-(5-(2-(1-(5-( 三氟甲氧基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 吡啶-2- 基) 胺甲酸酯(C13) From 5-(trifluoromethyl)-2-(3-vinyl-1 H -1,2,4-triazol-1-yl)pyridine (C5) and tert-butyl (2-chloro-4-) Preparation of iodophenyl)carbamate (0.200 g, 23%): ESI MS m/z 448 ([M+H] + ). Three-butyl (E) - (5- (2- (1- (5- ( trifluoromethoxy) pyridin-2-yl) -1 H -1,2,4- triazol-3-yl) Vinyl) pyridin-2- yl) carbamate (C13)

從5-(三氟甲基)-2-(3-乙烯基-1H -1,2,4-三唑-3-基)吡啶(C5) 及三級丁基 (2-氯-4-碘苯基)胺甲酸酯製備(0.250g，28%)：ESIMSm/z 448 ([M+H]+ )。三 級 丁基 (E )-(5-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-1- 基) 乙烯基) 吡啶-2- 基) 胺甲酸酯(C14) From 5-(trifluoromethyl)-2-(3-vinyl-1 H -1,2,4-triazol-3-yl)pyridine (C5) and tert-butyl (2-chloro-4-) Preparation of iodophenyl)carbamate (0.250 g, 28%): ESI MS m/z 448 ([M+H] + ). Three-butyl (E) - (5- (2- (1- (4- ( trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-1-yl) ethenyl) Pyridin-2- yl) carbamate (C14)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) 及三級丁基 (2-氯-4-碘苯基)胺甲酸酯製備(0.270g，31%)：ESIMSm/z 448 ([M+H]+ )。三 級 丁基 (E )-(4-(2-(1-(3- 氯-5-( 三氟甲基) 吡啶-2- 基)-1H -1,2,4- 三唑-1- 基) 乙烯基) 苯基) 胺甲酸酯(C15) From 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and tert-butyl (2-chloro-4-iodobenzene) Preparation of carbamic acid ester (0.270 g, 31%): ESI MS m/z 448 ([M+H] + ). Three-butyl (E) - (4- (2- (1- (3- chloro-5- (trifluoromethyl) pyridin-2-yl) -1 H -1,2,4- triazol -1 - yl) ethenyl) phenyl) carbamate (C15)

從3-氯-5-(三氟甲基)-2-(3-乙烯基-1H -1,2,4-三唑-3-基)吡啶(C6) 及三級丁基 (2-氯-4-碘苯基)胺甲酸酯製備(0.300g，35%)：1 H NMR (300 MHz, CDCl3 ) δ 8.91 (s, 1H), 8.72 (s, 1H), 8.20 (s, 1H), 7.70 (d,J = 16.0 Hz, 1H), 7.52 (d,J = 8.4 Hz, 2H), 7.39 (d,J = 8.4 Hz, 2H), 7.10 (d,J = 16.0 Hz, 1H), 6.53 (s, 1H), 1.56 (s, 9H)；ESIMSm/z 466 ([M+H]+ )。(E )-2- 甲氧基-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C16) From 3-chloro-5-(trifluoromethyl)-2-(3-vinyl-1 H -1,2,4-triazol-3-yl)pyridine (C6) and tert-butyl (2- Preparation of chloro-4-iodophenyl)carbamate (0.300 g, 35%): 1 H NMR (300 MHz, CDCl 3 ) δ 8.91 (s, 1H), 8.72 (s, 1H), 8.20 (s, 1H), 7.70 (d, J = 16.0 Hz, 1H), 7.52 (d, J = 8.4 Hz, 2H), 7.39 (d, J = 8.4 Hz, 2H), 7.10 (d, J = 16.0 Hz, 1H) , 6.53 (s, 1H), 1.56 (s, 9H); ESIMS m/z 466 ([M+H] + ). ( E )-2- Methoxy-4-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl ) aniline (C16)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) 及4-碘-2-甲氧基苯胺製備且單離為黃色固體(0.311g，70%)：mp 179-185 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.48 (d,J = 0.6 Hz, 1H), 7.79 - 7.68 (m, 2H), 7.61 (d,J = 16.2 Hz, 1H), 7.43 - 7.31 (m, 2H), 7.12 - 6.90 (m, 3H), 6.70 (d,J = 7.9 Hz, 1H), 3.98 (s, 2H), 3.91 (s, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03；13 C NMR (126 MHz, CDCl3 ) δ 163.55, 148.18, 147.23, 141.10, 137.34, 135.69, 135.55, 126.79, 122.39, 121.52, 121.41, 120.89, 119.36, 114.46, 112.94, 108.18, 55.44；ESIMSm/z 377 ([M+H]+ )。(E )-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基)-2-( 三氟甲基) 苯胺(C17) Prepared from 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and 4-iodo-2-methoxyaniline Yellow solid (0.311 g, 70%): mp 179-185 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.48 (d, J = 0.6 Hz, 1H), 7.79 - 7.68 (m, 2H), 7.61 (d, J = 16.2 Hz, 1H), 7.43 - 7.31 (m, 2H), 7.12 - 6.90 (m, 3H), 6.70 (d, J = 7.9 Hz, 1H), 3.98 (s, 2H), 3.91 (s, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.03; 13 C NMR (126 MHz, CDCl 3 ) δ 163.55, 148.18, 147.23, 141.10, 137.34, 135.69, 135.55, 126.79, 122.39, 121.52 , 121.41, 120.89, 119.36, 114.46, 112.94, 108.18, 55.44; ESIMS m/z 377 ([M+H] + ). ( E )-4-(2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl)-2-( III Fluoromethyl) aniline (C17)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4)及4-碘-2-(三氟甲基)苯胺製備且單離為黃色固體(0.383g，58%)： mp 170-180 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.49 (d,J = 0.6 Hz, 1H), 7.80 - 7.68 (m, 2H), 7.67 - 7.60 (m, 1H), 7.60 - 7.48 (m, 2H), 7.38 (dq,J = 7.9, 1.0 Hz, 2H), 7.00 (dd,J = 16.2, 0.6 Hz, 1H), 6.81 - 6.69 (m, 1H), 4.32 (s, 2H)；13 C NMR (126 MHz, CDCl3 ) δ 163.09, 148.27, 144.65, 141.17, 135.48, 133.87, 131.16, 126.06, 125.81, 125.77, 122.41, 120.94, 117.44, 114.60, 113.96；19 F NMR (471 MHz, CDCl3 ) δ -58.03, -62.89；ESIMSm/z 415 ([M+H]+ )。(E )-2- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C18) From 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and 4-iodo-2-(trifluoromethyl)aniline Prepared and isolated as a yellow solid (0.383 g, 58%): mp 170-180 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.49 (d, J = 0.6 Hz, 1H), 7.80 - 7.68 (m, 2H), 7.67 - 7.60 (m, 1H), 7.60 - 7.48 (m, 2H), 7.38 (dq, J = 7.9, 1.0 Hz, 2H), 7.00 (dd, J = 16.2, 0.6 Hz, 1H), 6.81 - 6.69 (m, 1H), 4.32 (s, 2H); 13 C NMR (126 MHz, CDCl 3 ) δ 163.09, 148.27, 144.65, 141.17, 135.48, 133.87, 131.16, 126.06, 125.81, 125.77, 122.41, 120.94, 117.44, 114.60, 113.96; 19 F NMR (471 MHz, CDCl 3 ) δ -58.03, -62.89; ESIMS m/z 415 ([M+H] + ). ( E )-2- fluoro-4-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) aniline (C18)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4)及2-氟-4-碘苯胺製備且單離為黃色固體(0.580g，73%)：mp 170-179 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.48 (s, 1H), 7.82 - 7.66 (m, 2H), 7.56 (d,J = 16.2 Hz, 2H), 7.37 (d,J = 8.4 Hz, 2H), 7.24 - 7.12 (m, 1H), 6.95 (d,J = 16.1 Hz, 1H), 6.82 - 6.70 (m, 1H), 3.88 (s, 2H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03, -135.23；13 C NMR (126 MHz, CDCl3 ) δ 163.19, 152.49, 150.59, 148.26, 135.49, 135.13, 134.34, 127.33, 124.05, 122.40, 120.96, 116.59, 114.36, 113.45；ESIMSm/z 365 ([M+H]+ )。(E )-2,6- 二氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C19) Prepared from 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and 2-fluoro-4-iodoaniline and isolated Yellow solid (0.580 g, 73%): mp 170-179 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.48 (s, 1H), 7.82 - 7.66 (m, 2H), 7.56 (d, J = 16.2 Hz, 2H), 7.37 (d, J = 8.4 Hz, 2H), 7.24 - 7.12 (m, 1H), 6.95 (d, J = 16.1 Hz, 1H), 6.82 - 6.70 (m, 1H), 3.88 (s , 2H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.03, -135.23; 13 C NMR (126 MHz, CDCl 3 ) δ 163.19, 152.49, 150.59, 148.26, 135.49, 135.13, 134.34, 127.33, 124.05, 122.40, 120.96, 116.59, 114.36, 113.45; ESIMS m/z 365 ([M+H] + ). ( E )-2,6 -Difluoro-4-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethene yl) aniline (C19)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) 及2,6-二氟-4-碘苯胺製備且單離為黃色固體(0.200g，44%)：mp 130-136 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.56 - 8.44 (m, 1H), 7.82 - 7.68 (m, 2H), 7.50 (d,J = 16.1 Hz, 1H), 7.44 - 7.30 (m, 2H), 7.05 (dd,J = 7.5, 2.1 Hz, 2H), 6.95 (d,J = 16.2 Hz, 1H), 3.88 (s, 2H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03, -132.53；13 C NMR (126 MHz, CDCl3 ) δ 162.81, 152.85, 152.78, 150.94, 150.87, 148.33, 148.31, 141.22, 135.43, 133.51, 133.48, 133.46, 125.65, 124.46, 122.42, 121.41, 120.98, 119.36, 115.68, 109.73, 109.68, 109.60, 109.55；ESIMSm/z 383 ([M+H]+ )。(E )-3- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C20) Prepared from 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and 2,6-difluoro-4-iodoaniline Isolation is a yellow solid (0.200 g, 44%): mp 130-136 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.56 - 8.44 (m, 1H), 7.82 - 7.68 (m, 2H), 7.50 ( d, J = 16.1 Hz, 1H), 7.44 - 7.30 (m, 2H), 7.05 (dd, J = 7.5, 2.1 Hz, 2H), 6.95 (d, J = 16.2 Hz, 1H), 3.88 (s, 2H 19 F NMR (376 MHz, CDCl 3 ) δ -58.03, -132.53; 13 C NMR (126 MHz, CDCl 3 ) δ 162.81, 152.85, 152.78, 150.94, 150.87, 148.33, 148.31, 141.22, 135.43, 133.51, 133.48, 133.46, 125.65, 124.46, 122.42, 121.41, 120.98, 119.36, 115.68, 109.73, 109.68, 109.60, 109.55; ESIMS m/z 383 ([M+H] + ). ( E )-3- fluoro-4-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) aniline (C20)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) 及3-氟-4-碘苯胺製備且單離為橘色固體(0.371g，64%)：mp 153-157 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.49 (d,J = 0.6 Hz, 1H), 7.80 - 7.64 (m, 3H), 7.44 - 7.31 (m, 3H), 7.06 (dd,J = 16.4, 0.7 Hz, 1H), 6.47 (dd,J = 8.3, 2.3 Hz, 1H), 6.40 (dd,J = 12.5, 2.3 Hz, 1H), 3.92 (s, 2H)；19 F NMR (471 MHz, CDCl3 ) δ -58.04, -115.03；ESIMSm/z 365 ([M+H]+ )。(E )-3-(2- 甲氧基-4- 硝基苯乙烯基)-1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑 (C21) Prepared from 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and 3-fluoro-4-iodoaniline and isolated Orange solid (0.371 g, 64%): mp 153-157 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.49 (d, J = 0.6 Hz, 1H), 7.80 - 7.64 (m, 3H), 7.44 - 7.31 (m, 3H), 7.06 (dd, J = 16.4, 0.7 Hz, 1H), 6.47 (dd, J = 8.3, 2.3 Hz, 1H), 6.40 (dd, J = 12.5, 2.3 Hz, 1H), 3.92 (s, 2H); 19 F NMR (471 MHz, CDCl 3 ) δ - 58.04, -115.03; ESIMS m/z 365 ([M+H] + ). ( E )-3-(2 -methoxy-4 -nitrostyryl)-1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazole ( C21)

從1-(4-(三氟甲氧基)苯基)-3-乙烯基-1H -1,2,4-三唑(C4) 及1-碘-2-甲氧基-4-硝基苯製備且單離為橘色固體(0.503g，78%)：mp 135-155 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.54 (d,J = 0.6 Hz, 1H), 7.99 (d,J = 16.5 Hz, 1H), 7.88 (ddd,J = 8.4, 2.2, 0.5 Hz, 1H), 7.81 - 7.67 (m, 4H), 7.45 - 7.32 (m, 3H), 4.02 (s, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03；ESIMSm/z 407 ([M+H]+ )。實施例6 ：(E )-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C22) 之製備 From 1-(4-(trifluoromethoxy)phenyl)-3-vinyl-1 H -1,2,4-triazole (C4) and 1-iodo-2-methoxy-4-nitro The benzene was prepared and isolated as an orange solid (0.503 g, 78%): mp 135-155 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.54 (d, J = 0.6 Hz, 1H), 7.99 (d , J = 16.5 Hz, 1H), 7.88 (ddd, J = 8.4, 2.2, 0.5 Hz, 1H), 7.81 - 7.67 (m, 4H), 7.45 - 7.32 (m, 3H), 4.02 (s, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ - 58.03; ESIMS m/z 407 ([M+H] + ). Example 6 : ( E )-4-(2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) aniline Preparation of (C22)

於0 ℃下將3,3,3-三氟乙酸(2.07 mL，26.9 mmol)逐滴地添加至配於二氯甲烷(7.5 mL)之三級丁基 (E )-(4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)胺甲酸酯(C7) (0.600g，1.34 mmol)。允許反應混合物攪拌，以及加溫至室溫。使反應濃縮，以及用二氯甲烷來稀釋粗殘餘物。添加飽和的碳酸鈉直到不再冒泡。添加水、將層予以分離，以及用二氯甲烷(3x)萃取水相。合併之有機物係用水及鹽水清洗，於硫酸鈉上乾燥、過濾以及濃縮，提供如灰白色固體之標題化合物(0.400g，85%)：mp 199-201 ℃；1 H NMR (400 MHz, DMSO-d6 ) δ 9.30 (s, 1H), 8.10 - 7.94 (m, 2H), 7.65 - 7.57 (m, 2H), 7.57 - 7.44 (m, 3H), 7.04 (d,J = 16.2 Hz, 1H), 6.92 - 6.76 (m, 2H), 3.71 (s, 2H)；19 F NMR (376 MHz, DMSO-d6 ) δ -56.98；ESIMSm/z 388 ([M+H]+ )。3,3,3-Trifluoroacetic acid (2.07 mL, 26.9 mmol) was added dropwise to the tertiary butyl ( E )-(4-(2-) in dichloromethane (7.5 mL) at 0 °C. (1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)carbamate (C7) (0.600 g, 1.34 mmol). The reaction mixture was allowed to stir and warmed to room temperature. The reaction was concentrated and the crude residue was diluted with dichloromethane. Add saturated sodium carbonate until no more bubbling. Water was added, the layers were separated, and the aqueous phase was extracted with dichloromethane (3×). The combined organics were washed with water-based and brine, dried over sodium sulfate, filtered and concentrated to provide an off-white solid as the title compound (0.400g, 85%): mp 199-201 ℃; 1 H NMR (400 MHz, DMSO- d 6 ) δ 9.30 (s, 1H), 8.10 - 7.94 (m, 2H), 7.65 - 7.57 (m, 2H), 7.57 - 7.44 (m, 3H), 7.04 (d, J = 16.2 Hz, 1H), 6.92 - 6.76 (m, 2H), 3.71 (s, 2H); 19 F NMR (376 MHz, DMSO - d 6 ) δ -56.98; ESIMS m/z 388 ([M+H] + ).

下列化合物係以實施例 6 中概述之流程相似的方式予以製備： (E )-3- 甲基-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C23) The following compounds were prepared in a similar manner to the procedure outlined in Example 6 : ( E )-3 -Methyl-4-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) aniline (C23)

從三級丁基 (E )-(3-甲基-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)胺甲酸酯(C8) 製備為灰白色固體(0.391g，99%)：mp 199-201 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.48 (d,J = 0.7 Hz, 1H), 7.86 (dt,J = 16.1, 0.6 Hz, 1H), 7.80 - 7.66 (m, 2H), 7.51 (d,J = 8.3 Hz, 1H), 7.37 (dq,J = 8.9, 1.0 Hz, 2H), 6.92 (dd,J = 16.1, 0.7 Hz, 1H), 6.61 - 6.45 (m, 2H), 3.00 (s, 2H), 2.42 (s, 3H)；19 F NMR (471 MHz, CDCl3 ) δ -58.03；13 C NMR (126 MHz, CDCl3 ) δ 163.71, 148.20, 146.90, 141.08, 138.24, 135.55, 132.72, 127.02, 125.55, 122.39, 120.97, 116.66, 114.15, 113.10, 20.08；ESIMSm/z 391 ([M+H]+ )。甲基 (E )-2- 胺基-5-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯甲酸酯(C24) From tertiary butyl( E )-(3-methyl-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazole-3 -Phenyl)phenyl)carbamate (C8) was prepared as an off-white solid (0.391 g, 99%): mp 199-201 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.48 (d, J = 0.7 Hz, 1H), 7.86 (dt, J = 16.1, 0.6 Hz, 1H), 7.80 - 7.66 (m, 2H), 7.51 (d, J = 8.3 Hz, 1H), 7.37 (dq, J = 8.9, 1.0 Hz, 2H), 6.92 (dd, J = 16.1, 0.7 Hz, 1H), 6.61 - 6.45 (m, 2H), 3.00 (s, 2H), 2.42 (s, 3H); 19 F NMR (471 MHz, CDCl 3) δ -58.03; 13 C NMR (126 MHz, CDCl 3) δ 163.71, 148.20, 146.90, 141.08, 138.24, 135.55, 132.72, 127.02, 125.55, 122.39, 120.97, 116.66, 114.15, 113.10, 20.08; ESIMS m /z 391 ([M+H] + ). Methyl( E )-2- amino-5-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethene yl) benzoate (C24)

從甲基 2-[雙(三級丁氧基羰基)胺基]-5-[(E )-2-[1-[4-(三氟甲氧基)苯基]-1,2,4-三唑-3-基]乙烯基]-苯甲酸酯(C9) 製備且單離為橘色固體(0.375g，99%)： mp 186-190 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.49 (s, 1H), 8.09 (d,J = 2.1 Hz, 1H), 7.79 - 7.68 (m, 2H), 7.60 (d,J = 16.2 Hz, 1H), 7.56 - 7.49 (m, 1H), 7.41 - 7.32 (m, 2H), 6.98 (d,J = 16.3 Hz, 1H), 6.69 (d,J = 8.6 Hz, 1H), 5.92 (s, 2H), 3.91 (s, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03；ESIMSm/z 405 ([M+H]+ )。(E )-2- 氯-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C25) From methyl 2-[bis(tertiarybutoxycarbonyl)amino]-5-[( E )-2-[1-[4-(trifluoromethoxy)phenyl]-1,2,4 -Triazol-3-yl]vinyl]-benzoate (C9) was prepared as an orange solid (0.375 g, 99%): mp 186-190 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.49 (s, 1H), 8.09 (d, J = 2.1 Hz, 1H), 7.79 - 7.68 (m, 2H), 7.60 (d, J = 16.2 Hz, 1H), 7.56 - 7.49 (m, 1H) , 7.41 - 7.32 (m, 2H), 6.98 (d, J = 16.3 Hz, 1H), 6.69 (d, J = 8.6 Hz, 1H), 5.92 (s, 2H), 3.91 (s, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ - 58.03; ESI MS m/z 405 ([M+H] + ). ( E )-2- Chloro-4-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) aniline (C25)

從三級丁基 (E )-(2-氯-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)胺甲酸酯(C10) 製備(0.363g，88%)：1 H NMR (400 MHz, CDCl3 ) δ 8.48 (d,J = 6.1 Hz, 1H), 7.73 (dd,J = 8.9, 6.4 Hz, 2H), 7.59 - 7.46 (m, 2H), 7.41 - 7.34 (m, 2H), 7.30 (dd,J = 8.3, 2.0 Hz, 1H), 6.96 (d,J = 16.2 Hz, 1H), 6.86 - 6.73 (m, 1H), 4.21 (s, 2H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03；ESIMSm/z 381 ([M+H]+ )。(E )-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 丙-1- 烯-1- 基) 苯胺 (C26) From tertiary butyl( E )-(2-chloro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazole-3- Preparation of phenyl)phenyl)carbamate (C10) (0.363 g, 88%): 1 H NMR (400 MHz, CDCl 3 ) δ 8.48 (d, J = 6.1 Hz, 1H), 7.73 (dd , J = 8.9, 6.4 Hz, 2H), 7.59 - 7.46 (m, 2H), 7.41 - 7.34 (m, 2H), 7.30 (dd, J = 8.3, 2.0 Hz, 1H), 6.96 (d, J = 16.2 Hz, 1H), 6.86 - 6.73 (m, 1H), 4.21 (s, 2H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.03; ESIMS m/z 381 ([M+H] + ). ( E )-4-(2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) prop-1 -ene-1- yl) aniline (C26)

從三級丁基 (E )-(4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)丙-1-烯-1-基)苯基)胺甲酸酯(C11) 製備且單離為灰白色固體(0.042g，18%)：mp 163-165 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.48 (s, 1H), 7.81 - 7.72 (m, 2H), 7.72 - 7.63 (m, 1H), 7.42 - 7.29 (m, 4H), 6.80 - 6.67 (m, 2H), 3.76 (s, 2H), 2.43 (d,J = 1.4 Hz, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -58.05；ESIMSm/z 360 ([M+H]+ )。(E )-4-(2-(1-(5-( 三氟甲氧基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C27) From tertiary butyl( E )-(4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)-propene - Preparation of 1-en-1-yl)phenyl)carbamate (C11) and isolated as an off-white solid (0.042 g, 18%): mp 163-165 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.48 (s, 1H), 7.81 - 7.72 (m, 2H), 7.72 - 7.63 (m, 1H), 7.42 - 7.29 (m, 4H), 6.80 - 6.67 (m, 2H), 3.76 (s, 2H), 2.43 (d, J = 1.4 Hz, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ - 58.05; ESIMS m/z 360 ([M+H] + ). ( E )-4-(2-(1-(5-( Trifluoromethoxy) pyridin-2- yl)-1 H -1,2,4- triazol-3 -yl) vinyl) aniline ( C27)

從三級丁基 (E )-(4-(2-(1-(5-(三氟甲氧基)吡啶-2-基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)胺甲酸酯(C12) 製備(0.250g，65%)：1 H NMR (300 MHz, CDCl3 ) δ 9.06 (s, 1H), 8.38 (s, 1H), 7.95 (d,J = 8.7 Hz, 1H), 7.75 (d,J = 8.7 Hz, 1H), 7.64 (d,J = 16.2 Hz, 1H), 7.41 (d,J = 8.4 Hz, 2H), 6.94 (d,J = 16.2 Hz, 1H), 6.68 (d,J = 8.7 Hz, 2H), 3.83 (s, 2H)；ESIMSm/z 348 ([M+H]+ )。(E)-4-(2-(1-(3- 氯-5-( 三氟甲基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C28) From tert-butyl( E )-(4-(2-(1-(5-(trifluoromethoxy)pyridin-2-yl)-1 H -1,2,4-triazol-3-yl) Preparation of vinyl)phenyl)carbamate (C12) (0.250 g, 65%): 1 H NMR (300 MHz, CDCl 3 ) δ 9.06 (s, 1H), 8.38 (s, 1H), 7.95 ( d, J = 8.7 Hz, 1H), 7.75 (d, J = 8.7 Hz, 1H), 7.64 (d, J = 16.2 Hz, 1H), 7.41 (d, J = 8.4 Hz, 2H), 6.94 (d, J = 16.2 Hz, 1H), 6.68 (d, J = 8.7 Hz, 2H), 3.83 (s, 2H); ESIMS m/z 348 ([M+H] + ). (E)-4-(2-(1-(3- chloro-5-( trifluoromethyl) pyridin-2- yl)-1 H -1,2,4- triazol-3 -yl) vinyl ) aniline (the C28)

從三級丁基 (E )-(4-(2-(1-(3-氯-5-(三氟甲基)吡啶-2-基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)胺甲酸酯(C15) 製備(0.300g，77%)：ESIMSm/z 366 ([M+H]+ )。實施例7 ：4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯胺(C29) 之製備 From tert-butyl( E )-(4-(2-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1 H -1,2,4-triazole- Preparation of 3-yl)vinyl)phenyl)carbamate (C15) (0.300 g, 77%): ESI MS m/z 366 ([M+H] + ). Example 7: 4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) ethyl) aniline (-C29) of preparation

將3-(4-硝基苯乙基)-1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑(C40) (10.2g，27.0 mmol)、附於碳上之鈀(10%，5.75g，2.70 mmol)、二氯甲烷(90.0 mL)及乙醇(45.0 mL)添加至500 mL燒瓶。將燒瓶放置於氫氣氛圍下(1大氣壓)。讓反應於室溫下攪拌過夜。催化劑係經由Celite®襯墊過濾來移除，以及用額外的二氯甲烷予以清洗。濃縮濾液，以提供標題化合物(7.37g，78%)：1 H NMR (400 MHz, DMSO-d6 ) δ 9.21 (s, 1H), 8.05 - 7.88 (m, 2H), 7.56 (d,J = 8.6 Hz, 2H), 7.01 - 6.80 (m, 2H), 6.62 - 6.36 (m, 2H), 4.93 (s, 2H), 3.02 - 2.78 (m, 4H)；19 F NMR (376 MHz, DMSO-d6 ) δ -57.01；13 C NMR (101 MHz, DMSO-d6 ) δ 164.54, 146 .78, 146.42, 142.74, 135.70, 128.63, 128.11, 122.47, 120.73, 114.02, 32.82, 30.11；ESIMSm/z 349 ([M+H]+ )。3-(4-Nitrophenylethyl)-1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazole (C40) (10.2 g, 27.0 mmol) Palladium (10%, 5.75 g, 2.70 mmol), dichloromethane (90.0 mL) and ethanol (45.0 mL) attached to carbon were added to a 500 mL flask. The flask was placed under a hydrogen atmosphere (1 atm). The reaction was allowed to stir at room temperature overnight. The catalyst was removed by filtration through a Celite® liner and washed with additional dichloromethane. The filtrate was concentrated to afford the title compound (7.37g, 78%): 1 H NMR (400 MHz, DMSO- d6) δ 9.21 (s, 1H), 8.05 - 7.88 (m, 2H), 7.56 (d, J = 8.6 Hz, 2H), 7.01 - 6.80 (m, 2H), 6.62 - 6.36 (m, 2H), 4.93 (s, 2H), 3.02 - 2.78 (m, 4H); 19 F NMR (376 MHz, DMSO- d 6 δ -57.01; 13 C NMR (101 MHz, DMSO- d 6 ) δ 164.54, 14 6 .78, 146.42, 142.74, 135.70, 128.63, 128.11, 122.47, 120.73, 114.02, 32.82, 30.11; ESIMS m/z 349 ([M+H] + ).

下列化合物係以實施例 7 中概述之流程相似的方式予以製備：(E )-3- 甲氧基-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C30) The following compounds were prepared in a similar manner to the procedure outlined in Example 7 : ( E )-3 -methoxy-4-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) aniline (C30)

從 (E )-3-(2-甲氧基-4-硝基苯乙醯基)-1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑(C21) 、使用乙酸乙酯作為溶劑來製備且單離為橘色固體(0.168g，45%)：1 H NMR (400 MHz, CDCl3 ) δ 8.54 (d,J = 0.6 Hz, 1H), 7.99 (d,J = 16.5 Hz, 1H), 7.88 (ddd,J = 8.4, 2.2, 0.5 Hz, 1H), 7.81 - 7.67 (m, 4H), 7.45 - 7.32 (m, 3H), 4.02 (s, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03；ESIMSm/z 407 ([M+H]+ )。4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 丙基) 苯胺(C31) From ( E )-3-(2-methoxy-4-nitrophenethyl)-1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-tri The azole (C21) was prepared using ethyl acetate as a solvent and isolated as an orange solid (0.168 g, 45%): 1 H NMR (400 MHz, CDCl 3 ) δ 8.54 (d, J = 0.6 Hz, 1H) , 7.99 (d, J = 16.5 Hz, 1H), 7.88 (ddd, J = 8.4, 2.2, 0.5 Hz, 1H), 7.81 - 7.67 (m, 4H), 7.45 - 7.32 (m, 3H), 4.02 (s , 3H); 19 F NMR ( 376 MHz, CDCl 3) δ -58.03; ESIMS m / z 407 ([m + H] +). 4-(2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) propyl) aniline (C31)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)丙-1-烯-1-基)苯胺(C26) 、使用乙酸乙酯作為溶劑來製備，且單離為灰白色固體(0.039g，91%)：1 H NMR (400 MHz, CDCl3 ) δ 8.43 (s, 1H), 7.73 - 7.61 (m, 2H), 7.41 - 7.30 (m, 2H), 7.06 - 6.91 (m, 2H), 6.66 - 6.54 (m, 2H), 3.55 (s, 2H), 3.33 - 3.19 (m, 1H), 3.13 (dd,J = 13.6, 6.3 Hz, 1H), 2.76 (dd,J = 13.6, 8.6 Hz, 1H), 1.32 (d,J = 6.9 Hz, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -58.06；ESIMSm/z 363 ([M+H]+ )。2- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯胺(C32) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)prop-1-ene-1 - phenylamine (C26) , using ethyl acetate as solvent, and isolated as an off-white solid (0.039 g, 91%): 1 H NMR (400 MHz, CDCl 3 ) δ 8.43 (s, 1H), 7.73 - 7.61 (m, 2H), 7.41 - 7.30 (m, 2H), 7.06 - 6.91 (m, 2H), 6.66 - 6.54 (m, 2H), 3.55 (s, 2H), 3.33 - 3.19 (m, 1H) , 3.13 (dd, J = 13.6, 6.3 Hz, 1H), 2.76 (dd, J = 13.6, 8.6 Hz, 1H), 1.32 (d, J = 6.9 Hz, 3H); 19 F NMR (376 MHz, CDCl 3 δ -58.06; ESIMS m/z 363 ([M+H] + ). 2- fluoro-4-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) aniline (C32)

從(E )-2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C18) 製備(0.250g，73%)：1 H NMR (400 MHz, CDCl3 ) δ 8.44 (s, 1H), 7.79 - 7.59 (m, 2H), 7.43 - 7.30 (m, 2H), 6.89 (dd,J = 12.0, 1.9 Hz, 1H), 6.83 (dd,J = 8.3, 1.7 Hz, 1H), 6.70 (dd,J = 9.2, 8.0 Hz, 1H), 3.61 (s, 2H), 3.17 - 2.94 (m, 4H)；19 F NMR (471 MHz, CDCl3 ) δ -58.05, -135.16；13 C NMR (126 MHz, CDCl3 ) δ 165.32, 152.55, 150.65, 148.24, 141.03, 135.54, 132.42, 132.06, 124.21, 122.35, 121.13, 116.98, 115.16, 33.30, 30.31；ESIMSm/z 367 ([M+H]+ )。4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 環丙基)- 苯胺(C33) From ( E )-2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl) Preparation of aniline (C18) (0.250 g, 73%): 1 H NMR (400 MHz, CDCl 3 ) δ 8.44 (s, 1H), 7.79 - 7.59 (m, 2H), 7.43 - 7.30 (m, 2H), 6.89 (dd, J = 12.0, 1.9 Hz, 1H), 6.83 (dd, J = 8.3, 1.7 Hz, 1H), 6.70 (dd, J = 9.2, 8.0 Hz, 1H), 3.61 (s, 2H), 3.17 - 2.94 (m, 4H); 19 F NMR (471 MHz, CDCl 3 ) δ -58.05, -135.16; 13 C NMR (126 MHz, CDCl 3 ) δ 165.32, 152.55, 150.65, 148.24, 141.03, 135.54, 132.42, 132.06 , 124.21, 122.35, 121.13, 116.98, 115.16, 33.30, 30.31; ESIMS m/z 367 ([M+H] + ). 4-(2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) cyclopropyl) -phenylamine (C33)

從3-(2-(4-硝基苯基)環丙基)-1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑(C42) 製備(0.074g，89%)：1 H NMR (400 MHz, CDCl3 ) δ 8.41 (d,J = 15.7 Hz, 1H), 7.73 - 7.63 (m, 2H), 7.38 - 7.30 (m, 2H), 7.03 - 6.95 (m, 2H), 6.67 - 6.58 (m, 2H), 3.58 (d,J = 15.7 Hz, 2H), 2.48 (ddd,J = 9.0, 6.1, 4.4 Hz, 1H), 2.33 (ddd,J = 8.7, 5.5, 4.4 Hz, 1H), 1.62 (ddd,J = 9.0, 5.6, 4.7 Hz, 1H), 1.39 (ddd,J = 8.7, 6.2, 4.6 Hz, 1H)；19 F NMR (376 MHz, CDCl3 ) δ -58.03；ESIMSm/z 361 ([M+H]+ )。實施例8 ：(E )-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯胺(C22) 之製備 Preparation of 3-(2-(4-nitrophenyl)cyclopropyl)-1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazole (C42) (0.074g, 89%): 1 H NMR (400 MHz, CDCl 3) δ 8.41 (d, J = 15.7 Hz, 1H), 7.73 - 7.63 (m, 2H), 7.38 - 7.30 (m, 2H), 7.03 - 6.95 (m, 2H), 6.67 - 6.58 (m, 2H), 3.58 (d, J = 15.7 Hz, 2H), 2.48 (ddd, J = 9.0, 6.1, 4.4 Hz, 1H), 2.33 (ddd, J = 8.7, 5.5, 4.4 Hz, 1H), 1.62 (ddd, J = 9.0, 5.6, 4.7 Hz, 1H), 1.39 (ddd, J = 8.7, 6.2, 4.6 Hz, 1H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.03; ESIMS m/z 361 ([M+H] + ). Example 8 : ( E )-4-(2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) aniline Preparation of (C22)

將(E )-3-(4-硝基苯乙烯基)-1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑(C41) (0.100g，0.266 mmol)、鋅粉(0.100g，1.53 mmol)，以及乙酸(1.3 mL)添加至20 mL小瓶。反應係於室溫下攪拌歷時30分鐘。添加額外之乙酸等分試樣(2.0 mL)。讓反應於室溫下攪拌過夜。用水稀釋反應，小心地用含水氫氧化鈉予以鹼化，以及用乙酸乙酯來萃取。組合的有機層係於硫酸鎂上乾燥、過濾及濃縮，以提供標題化合物(0.0810g，79%)：1 H NMR (400 MHz, DMSO-d6 ) δ 9.27 (s, 1H), 8.03 - 7.97 (m, 2H), 7.59 (d,J = 8.6 Hz, 2H), 7.36 (d,J = 8.5 Hz, 3H), 6.88 (d,J = 16.2 Hz, 1H), 6.58 (d,J = 8.4 Hz, 2H), 5.47 (s, 2H)；19 F NMR (376 MHz, DMSO-d6 ) δ -56.97；ESIMSm/z 347 ([M+H]+ )。實施例9 ：1-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(1-((Z)-3-(2-isopropyl-5-methylphenyl)-4- oxothiazolidin-2-ylidene)-3-(4-((E)-2-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)vinyl)phenyl)urea) (F38) 之製備 ( E )-3-(4-Nitrostyryl)-1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazole (C41) (0.100 g , 0.266 mmol), zinc powder (0.100 g, 1.53 mmol), and acetic acid (1.3 mL) were added to a 20 mL vial. The reaction was stirred at room temperature for 30 minutes. An additional aliquot of acetic acid (2.0 mL) was added. The reaction was allowed to stir at room temperature overnight. The reaction was diluted with water, carefully basified with aqueous sodium hydroxide and extracted with ethyl acetate. The organic layer was combined based on magnesium sulfate, filtered and concentrated to afford the title compound (0.0810g, 79%): 1 H NMR (400 MHz, DMSO- d 6) δ 9.27 (s, 1H), 8.03 - 7.97 (m, 2H), 7.59 (d, J = 8.6 Hz, 2H), 7.36 (d, J = 8.5 Hz, 3H), 6.88 (d, J = 16.2 Hz, 1H), 6.58 (d, J = 8.4 Hz , 2H), 5.47 (s, 2H); 19 F NMR (376 MHz, DMSO- d 6 ) δ -56.97; ESIMS m/z 347 ([M+H] + ). Example 9: 1 - ((Z) -3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) - 2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (1-((Z)-) 3-(2-isopropyl-5-methylphenyl)-4-oxothiazolidin-2-ylidene)-3-(4-((E)-2-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2 , 4-triazol-3-yl ) vinyl) phenyl) urea) (F38) preparation of

步驟1：4-硝基苯基 (E )-(4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)胺甲酸酯之製備 將(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) (0.100g，0.289 mmol)及四氫呋喃(5 mL)添加至反應小瓶。於室溫下逐滴地添加4-硝基苯基碳醯氯酯(0.0582g，0.289 mmol)配於四氫呋喃，以及反應混合物係於室溫下攪拌歷時1小時。讓反應混合物濃縮，以提供標題化合物，其能未經進一步純化即使用。Step 1: 4-Nitrophenyl( E )-(4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazole-3- Preparation of (meth)phenyl)phenyl)carbamate ( E )-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4- Triazol-3-yl)vinyl)aniline (C22) (0.100 g, 0.289 mmol) and tetrahydrofuran (5 mL) were added to the reaction vial. 4-Nitrophenylcarbonium chloride (0.0582 g, 0.289 mmol) was added dropwise to tetrahydrofuran at room temperature, and the reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated to give the title compound.

步驟2：1-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F38)之製備 將2-亞胺基-3-(2-異丙基-5-甲基苯基)噻唑烷-4-酮(0.0717g，0.289 mmol)、碳酸銫(0.0940g，0.289 mmol)，以及N,N -二乙基異丙胺(0.101 mL，0.578 mmol)添加至溶解於乙腈(5.00 mL)內的(E )-4-硝基苯基 (4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)胺甲酸酯(C34) 。允許反應混合物於室溫下攪拌。將反應混合物倒至水內，以及用乙酸乙酯(3 x)來萃取水層。合併之有機層係用水及鹽水清洗、乾燥、過濾以及濃縮。藉由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷B作為沖提液，B為二氯甲烷/己烷(1:1)，提供如灰白色固體之標題化合物(0.126g，70%)。Step 2: 1-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)-3-(4-(( E )-2 -(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F38) Preparation 2-A Amino-3-(2-isopropyl-5-methylphenyl)thiazolidin-4-one (0.0717 g, 0.289 mmol), cesium carbonate (0.0940 g, 0.289 mmol), and N,N -diethyl Isopropylamine (0.101 mL, 0.578 mmol) was added to ( E )-4-nitrophenyl (4-(2-(1-(4-(trifluoromethoxy)) dissolved in acetonitrile (5.00 mL) Phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)carbamate (C34) . The reaction mixture was allowed to stir at room temperature. The reaction mixture was poured into water and aqueous layer was extracted with ethyl acetate (3x). The combined organic layers were washed with water and brine, dried, filtered and concentrated. Purification by flash column chromatography using EtOAc / EtOAc EtOAc (EtOAc) , 70%).

下列化合物係以實施例 9 中概述之流程相似的方式予以製備：(Z )-1-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 丙基) 苯 基) 脲(F15) The following compound is to be similar to the embodiments outlined in Scheme 9 prepared in a manner: (Z) -1- (3- ( 2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene yl) -3- (4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) propyl) phenyl) Urea (F15)

從4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)丙基)苯胺(C31) 製備為灰白色固體(0.050g，72%)。(Z)-1-(3-(2-( 甲氧基甲基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯 基) 脲(F21) Prepared as an off-white solid from 4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)propyl)phenylamine (C31) (0.050 g, 72%). (Z) -1- (3- (2- ( methoxymethyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1 - (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) ethyl) phenyl) urea (F21)

從4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙基)苯胺(C29) 製備為灰白色固體(0.118g，65%)。(Z )-1-(2- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯 基)-3-(3-(2-( 甲氧基甲基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F22) Prepared as an off-white solid from 4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethyl)phenylamine (C29) (0.118g, 65%). (Z) -1- (2- fluoro-4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) acetate yl) phenyl) -3- (3- (2- (methoxymethyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F 22)

從2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙基)苯胺(C32) 製備為淡橘色固體(0.089g，59%)。(Z )-1-(3-(2-( 二級丁氧基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(2- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F24) From 2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethyl)aniline (C32) Prepared as a pale orange solid (0.089 g, 59%). (Z) -1- (3- (2- ( two-butoxy) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (2-fluoro-4- ( 2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F24)

從2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙基)苯胺(C32) 製備為灰白色泡沫(0.041g，40%)。(Z )-1-(2- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基)-3-(3-(5- 甲基-2- 丙基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F26) From 2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethyl)aniline (C32) Prepared as an off-white foam (0.041 g, 40%). (Z) -1- (2- fluoro-4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) acetate yl) phenyl) -3- (3- (5-methyl-2-propylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F26)

從2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙基)苯胺(C32) 製備為灰白色泡沫(0.078g，71%)。(Z )-1-(3-(2-(2,2- 二氟環丙基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F28) From 2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethyl)aniline (C32) Prepared as an off-white foam (0.078 g, 71%). (Z) -1- (3- (2- (2,2- difluoro-cyclopropyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- ( 2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F28)

從4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙基)苯胺(C29) 製備為灰白色固體(0.061g，32%)。(Z )-1-(3-(2-(1- 甲氧基乙基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯 基) 脲(F31) Prepared as an off-white solid from 4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethyl)phenylamine (C29) (0.061 g, 32%). (Z) -1- (3- (2- (1- methoxyethyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) ethyl) phenyl) urea (F31)

從4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙基)苯胺(C29) 製備為淡黃色固體(0.051g，55%)。(Z )-1-(3- 環己 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F35) Prepared as light yellow from 4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethyl)phenylamine (C29) Solid (0.051 g, 55%). ( Z )-1-(3 -Cyclohexyl )-4 -oxoththiazolidine-2- yl)-3-(4-(2-(1-(4-( trifluoromethoxy) phenyl)) -1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F35)

從4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙基)苯胺(C29) 製備為白色固體(0.086g，52%)。(Z)-1-(3-(2- 異丙基-5- 甲基苯 基) 噻唑-2(3H )- 亞基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F36) Prepared as a white solid from 4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethyl)phenylamine (C29) (0.086g, 52%). (Z) -1- (3- (2- isopropyl-5-methylphenyl) thiazol -2 (3 H) - ylidene) -3- (4- (2- (1- (4- ( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F36)

從4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙基)苯胺(C29) 製備(0.075g，85%)。(Z )-1-(2- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基)-3-(3-(2- 異丙基-5- 甲基苯 基) 噻唑-2(3H )- 亞基) 脲(F37) Prepared from 4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethyl)phenylamine (C29) (0.075 g , 85%). (Z) -1- (2- fluoro-4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) acetate yl) phenyl) -3- (3- (2-isopropyl-5-methylphenyl) thiazol -2 (3 H) - ylidene) urea (F37)

從4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙基)苯胺(C32)製備(0.076g，88%)。1-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(3- 甲基-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F39) Prepared from 4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethyl)phenylamine (C32) (0.076 g , 88%). 1 - ((Z) -3- ( 2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (3-methyl -4 - ((E) -2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F39)

從(E )-3-甲基-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C23 )製備為灰白色固體(0.243g，68%)。1-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(3- 甲氧基-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F40) From ( E )-3-methyl-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl The aniline (C23 ) was obtained as an off-white solid (0.243 g, 68%). 1 - ((Z) -3- ( 2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (3-methoxy -4 - ((E )-2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F40)

從(E )-3-甲氧基-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C30) 製備為紅色固體(0.018g，13%)。1-((Z )-3-(2- 氟-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F41) From ( E )-3-methoxy-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethene The aniline (C30) was prepared as a red solid (0.018 g, 13%). 1 - ((Z) -3- ( 2- fluoro-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) -2- (1- ( 4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F41)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體(0.095g，55%)。1-((Z )-3-(2- 甲氧基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F42) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.095 g, 55%). 1 - ((Z) -3- ( 2- methoxy-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) -2- (1 -(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F42)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體(0.114g，54%)。1-((Z )-3-(5- 甲基-2-( 三氟甲基) 苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F43) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.114 g, 54%). 1 - ((Z) -3- ( 5- methyl-2- (trifluoromethyl) phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) -2 -(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F43)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為淡黃色固體 (0.116g，51%)。1-((Z )-3-(2- 氯-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F44) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as a pale yellow solid (0.116 g, 51%). 1 - ((Z) -3- ( 2- chloro-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) -2- (1- ( 4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F44)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體 (0.092g，52%)。1-((Z )-3-(5- 甲基-2- 丙基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F45) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.092 g, 52%). 1 - ((Z) -3- ( 5- methyl-2-propylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) -2- (1- (4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F45)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體 (0.108g，61%)。1-((Z )-3-(2- 乙氧基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F46) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.108 g, 61%). 1 - ((Z) -3- ( 2- ethoxy-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) -2- (1 -(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F46)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體 (0.081g，45%)。1-((Z )-3-(4- 氟-2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F47) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.081 g, 45%). 1 - ((Z) -3- ( 4- fluoro-2-isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) - 2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F47)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體 (0.126g，68%)。1-((Z )-3-(2-( 二級丁氧基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F48) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.126 g, 68%). 1 - ((Z) -3- ( 2- ( two-butoxy) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) - 2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F48)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體 (0.118g，62%)。1-((Z )-3-(2- 異丙氧基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F49) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.118 g, 62%). 1 - ((Z) -3- ( 2- isopropoxy-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) -2- ( 1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F49)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體 (0.108g，58%)。1-((Z )-3-(5- 甲基-2-( 三氟甲氧基) 苯基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F50) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.108 g, 58%). 1-(( Z )-3-(5 -methyl-2-( trifluoromethoxy) phenyl)-4 -oxoththiazin-2- yl)-3-(4-(( E )- 2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F50)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體 (0.134g，69%)。1-((Z )-3-(5- 甲基-2-(2,2,2- 三氟乙氧基) 苯基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F51) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.134 g, 69%). 1-(( Z )-3-(5 -methyl-2-(2,2,2- trifluoroethoxy) phenyl)-4 -oxoththiazin-2- yl)-3-(4) -(( E )-2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F51 )

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為黃色固體 (0.130g，66%)。1-((Z )-3-(2-( 三 級丁氧基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F52) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as a yellow solid (0.130 g, 66%). 1 - ((Z) -3- ( 2- ( three-butoxy) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) - 2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F52)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為灰白色固體 (0.151g，80%)。1-((Z )-3-(2-( 甲氧基甲基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F53) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an off-white solid (0.151 g, 80%). 1 - ((Z) -3- ( 2- ( methoxymethyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) - 2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F53)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為黃色固體 (0.118g，65%)。甲基 2-(3-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲基)-5-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯甲酸酯(F54) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as a yellow solid (0.118 g, 65%). Methyl 2- (3 - ((Z) -3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) ureido) -5 - ((E) -2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) benzoate (F54)

從甲基 (E )-2-胺基-5-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯甲酸酯(C24) 製備(0.078g，46%)。1-(2- 氟-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基)-3-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F55) From methyl( E )-2-amino-5-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl) Preparation of vinyl)benzoate (C24) (0.078 g, 46%). 1-(2- Fluoro-4-(( E )-2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethene yl) phenyl) -3 - ((Z) -3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F55)

從(E )-2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C18) 製備為白色固體 (0.110g，63%)。1-(2- 氯-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基)-3-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F56) From ( E )-2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl) The aniline (C18) was obtained as a white solid (0.110 g, 63%). 1-(2- chloro-4-(( E )-2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethene yl) phenyl) -3 - ((Z) -3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F56)

從(E )-2-氯-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C25) 製備(0.092g，53%)。1-(2,6- 二氟-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基)-3-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F57) From ( E )-2-chloro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl) Preparation of aniline (C25) (0.092 g, 53%). 1-(2,6 -Difluoro-4-(( E )-2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazole-3- yl) ethenyl) phenyl) -3 - ((Z) -3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F57)

從(E )-2,6-二氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C19) 製備為灰白色固體(0.100g，57%)。1-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(2- 甲氧基-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F58) From ( E )-2,6-difluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl) The vinyl aniline (C19) was prepared as an off-white solid (0.100 g, 57%). 1 - ((Z) -3- ( 2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (2-methoxy -4 - ((E )-2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F58)

從(E )-2-甲氧基-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C16) 製備(0.092g，53%)。1-(2- 氟-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基)-3-((Z )-3-(2-( 甲氧基甲基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F59) From ( E )-2-methoxy-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)ethene Preparation of aniline (C16) (0.092 g, 53%). 1-(2- Fluoro-4-(( E )-2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethene yl) phenyl) -3 - ((Z) -3- (2- ( methoxymethyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F59)

從(E )-2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C18) 製備為灰白色固體(0.101g，57%)。1-((Z )-3-(2-( 二級丁氧基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(2- 氟-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F60) From ( E )-2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl) The aniline (C18) was obtained as an off-white solid (0.101 g, 57%). 1 - ((Z) -3- ( 2- ( two-butoxy) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (2-fluoro-4- ( ( E )-2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F60)

從(E )-2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C18) 製備為橘色泡沫(0.060g，32%)。1-(3- 氟-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基)-3-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F61) From ( E )-2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl) Aniline (C18) was prepared as an orange foam (0.060 g, 32%). 1-(3- Fluoro-4-(( E )-2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethene yl) phenyl) -3 - ((Z) -3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F61)

從(E )-3-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C20) 製備為黃色泡沫(0.099g，56%)。1-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基)-2-( 三氟甲基) 苯 基) 脲(F62) From ( E )-3-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl) The aniline (C20) was prepared as a yellow foam (0.099 g, 56%). 1 - ((Z) -3- ( 2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) -2- (1 - (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) vinyl) -2- (trifluoromethyl) phenyl) urea (F62)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)-2-(三氟甲基)苯胺(C17) 製備(0.083g，49%)。1-(2- 氟-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基)-3-((Z )-3-(5- 甲基-2- 丙基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F63) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)-2-( trifluoromethyl) aniline (C17) was prepared (0.083g, 49%). 1-(2- Fluoro-4-(( E )-2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethene yl) phenyl) -3 - ((Z) -3- (5- methyl-2-propylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F63)

從(E )-2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C18) 製備為灰白色固體 (0.069g，65%)。1-(2- 氟-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基)-3-((Z )-3-(2- 異丙基-5-( 三氟甲基) 苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F64) From ( E )-2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl) The aniline (C18) was obtained as an off-white solid (0.069 g, 65%). 1-(2- Fluoro-4-(( E )-2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethene yl) phenyl) -3 - ((Z) -3- (2- isopropyl-5- (trifluoromethyl) phenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F64)

從(E )-2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C18) 製備為橘色固體(0.104g，54%)。1-((Z )-3-(2- 異丙基-5-( 三氟甲基) 苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F65) From ( E )-2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl) The aniline (C18) was prepared as an orange solid (0.104 g, 54%). 1 - ((Z) -3- ( 2- isopropyl-5- (trifluoromethyl) phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) - 2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F65)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為橘色固體 (0.112g，57%)。1-((Z )-3-(2-(2,2- 二氟環丙基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F66) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as an orange solid (0.112 g, 57%). 1 - ((Z) -3- ( 2- (2,2- difluoro-cyclopropyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- ( ( E )-2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F66)

從(E )-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C22) 製備為淡橘色固體 (0.043g，56%)。1-((Z )-3-(2-(2,2- 二氟環丙基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(2- 氟-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F67) From ( E )-4-(2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C22) Prepared as a light orange solid (0.043 g, 56%). 1 - ((Z) -3- ( 2- (2,2- difluoro-cyclopropyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (2-fluoro 4-(( E )-2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F67)

從(E )-2-氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C18) 製備為橘色固體 (0.082g，55%)。1-(2,6- 二氟-4-((E )-2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基)-3-((Z )-3-(2-( 甲氧基甲基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F68) From ( E )-2-fluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl) The aniline (C18) was prepared as an orange solid (0.082 g, 55%). 1-(2,6 -Difluoro-4-(( E )-2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazole-3- yl) ethenyl) phenyl) -3 - ((Z) -3- (2- ( methoxymethyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) urea ( F68)

從(E )-2,6-二氟-4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C19) 製備為橘色固體(0.102g，50%)。1-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-((E )-2-(1-(5-( 三氟甲氧基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基) 脲(F69) From ( E )-2,6-difluoro-4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl) Vinyl)aniline (C19) was prepared as an orange solid (0.102 g, 50%). 1 - ((Z) -3- ( 2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) -2- (1 -(5-( trifluoromethoxy) pyridin-2- yl)-1 H -1,2,4- triazol-3 -yl) vinyl) phenyl) urea (F69)

從(E )-4-(2-(1-(5-(三氟甲氧基)吡啶-2-基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C27) 製備為灰白色固體(0.096g，27%)。1-(4-((E )-2-(1-(3- 氯-5-( 三氟甲基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 苯基)-3-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F72) From ( E )-4-(2-(1-(5-(Trifluoromethoxy)pyridin-2-yl)-1 H -1,2,4-triazol-3-yl)vinyl)aniline (C27) Prepared as an off-white solid (0.096 g, 27%). 1- (4 - ((E) -2- (1- (3- chloro-5- (trifluoromethyl) pyridin-2-yl) -1 H -1,2,4- triazol-3-yl ) ethenyl) phenyl) -3 - ((Z) -3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F72)

從(E )-4-(2-(1-(3-氯-5-(三氟甲基)吡啶-2-基)-1H -1,2,4-三唑-3-基)乙烯基)苯胺(C28) 製備為棕色固體(0.170g，24%)。(Z)-1-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 環丙基) 苯基) 脲(F73) From ( E )-4-(2-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1 H -1,2,4-triazol-3-yl)ethene The aniline (C28) was prepared as a brown solid (0.170 g, 24%). (Z) -1- (3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (4- ( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) cyclopropyl) phenyl) urea (F73)

從4-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)環丙基)-苯胺(C33) 製備為灰白色固體(0.054g，47%)。實施例10 ：1-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(5-((E )-2-(1-(5-( 三氟甲氧基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 吡啶-2- 基) 脲(F71) 之製備 Prepared from 4-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)cyclopropyl)-phenylamine (C33) Off-white solid (0.054 g, 47%). Example 10: 1 - ((Z) -3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (5 - ((E ) - 2-(1-(5-( Trifluoromethoxy) pyridin-2- yl)-1 H -1,2,4- triazol-3 -yl) vinyl) pyridin-2- yl) urea (F71 ) the preparation

將三級丁基 (E )-(5-(2-(1-(5-(三氟甲氧基)吡啶-2-基)-1H -1,2,4-三唑-3-基)乙烯基)吡啶-2-基)胺甲酸酯(0.500g，1.12 mmol)(C13) 、2-亞胺基-3-(2-異丙基-5-甲基苯基)噻唑烷-4-酮(0.550g，2.24 mmol)及甲苯(11 mL)添加至反應小瓶。將小瓶密封且加熱至120℃歷時24小時。使反應混合物濃縮。藉由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷作為沖提液，提供如灰白色固體之標題化合物(0.0800g，25%)。Tert-butyl( E )-(5-(2-(1-(5-(trifluoromethoxy)pyridin-2-yl)-1 H -1,2,4-triazol-3-yl) )vinyl)pyridin-2-yl)carbamate (0.500 g, 1.12 mmol) (C13) , 2-imino-3-(2-isopropyl-5-methylphenyl)thiazolidine- 4-ketone (0.550 g, 2.24 mmol) and toluene (11 mL) were added to the reaction vial. The vial was sealed and heated to 120 °C for 24 hours. The reaction mixture was concentrated. The title compound (0.0800 g, 25%) was obtained eluted elute

下列化合物係以實施例 10 中概述之流程相似的方式予以製備：1-((Z )-3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(5-((E )-2-(1-(4- ( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙烯基) 吡啶-2- 基) 脲(F70) The following compounds were prepared in the manner to be based outlined in Example 10, the similar process: 1 - ((Z) -3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene 3-(5-(( E )-2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) vinyl ) pyridin-2-yl) urea (F70)

從三級丁基 (E )-(5-(2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)吡啶-2-基)胺甲酸酯(C14) 製備且單離為灰白色固體(0.085g，37%)。實施例11 ：(Z )-1-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F1) 之製備 From tertiary butyl( E )-(5-(2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl Pyridin-2-yl)carbamate (C14) was prepared as a white solid (0.085 g, 37%). Example 11 :( Z) -1- (3- ( 2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1 Preparation of -(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F1)

將1-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F38) (0.109g，0.176 mmol)及附於碳上之鈀(10%，0.0500g，0.0470 mmol)添加至25 mL反應小瓶。添加乙酸乙酯(1.8 mL)，以及將小瓶密封。使小瓶排氣，繼而用氫氣來重新填充(氣球) (3x)。反應混合物係於氫氣下由氣球予以攪拌歷時2小時。反應混合物係經Celite®過濾以及濃縮。藉由急速管柱層析法予以純化，其係使用0-100%乙酸乙酯/B作為沖提液，B為二氯甲烷/己烷(1:1)，提供如灰白色固體之標題化合物(0.0790g，72%)。1-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothiazolidine-2-yl)-3-(4-(( E )-2-() 1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F38) (0.109 g, 0.176 mmol) Palladium (10%, 0.0500 g, 0.0470 mmol) attached to carbon was added to a 25 mL reaction vial. Ethyl acetate (1.8 mL) was added and the vial was sealed. The vial is vented and then refilled with hydrogen (balloon) (3x). The reaction mixture was stirred by a balloon under hydrogen for 2 hours. The reaction mixture was filtered through Celite® and concentrated. Purification by flash column chromatography using 0-100% EtOAc/EtOAc (EtOAc) 0.0790g, 72%).

下列化合物係以實施例 11 中概述之流程相似的方式予以製備：(Z )-1-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(3- 甲基-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F2) The following compounds were prepared in the manner to be based outlined in Example 11, the similar process: (Z) -1- (3- ( 2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene yl) -3- (3-methyl-4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) acetate yl) phenyl) urea (F2)

從1-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(3-甲基-4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F39) 製備(0.108g，89%)。(Z )-1-(3-(2- 氟-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F3) From 1-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)-3-(3-methyl-4-(( E) Preparation of 2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F39) (0.108 g, 89%). (Z) -1- (3- (2- fluoro-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (4- (three Fluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F3)

從1-((Z )-3-(2-氟-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F41) 製備為橘色固體(0.102g，50%)。(Z )-1-(3-(2- 甲氧基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F4) From 1-(( Z )-3-(2-fluoro-5-methylphenyl)-4-oxothazol-2-yl)-3-(4-(( E )-2-(1- (4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F41) was prepared as an orange solid (0.102 g, 50 %). (Z) -1- (3- (2- methoxy-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (4- ( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F4)

從1-((Z )-3-(2-甲氧基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F42) 製備為白色固體(0.013g，19%)。(Z)-1-(3-(5- 甲基-2-( 三氟甲基) 苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F5) From 1-(( Z )-3-(2-methoxy-5-methylphenyl)-4-oxothazol-2-yl)-3-(4-(( E )-2-() 1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F42) was obtained as a white solid (0.013 g, 19%). (Z) -1- (3- (5- methyl-2- (trifluoromethyl) phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1 (4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F5)

從1-((Z )-3-(5-甲基-2-(三氟甲基)苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F43) 製備為白色固體 (0.050g，75%)。(Z )-1-(3-(2- 氯-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F6) From 1-(( Z )-3-(5-methyl-2-(trifluoromethyl)phenyl)-4-oxothazol-2-yl)-3-(4-(( E )- 2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F43) was prepared as a white solid ( 0.050 g, 75%). (Z) -1- (3- (2- chloro-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (4- (three Fluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F6)

從1-((Z )-3-(2-氯-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F44) 製備為白色固體 (0.031g，58%)。(Z )-1-(3-(5- 甲基-2- 丙基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F7) From 1-(( Z )-3-(2-chloro-5-methylphenyl)-4-oxothazol-2-yl)-3-(4-(( E )-2-(1- (4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F44) was obtained as a white solid (0.031 g, 58% ). (Z) -1- (3- (5- methyl-2-propylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (4- ( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F7)

從1-((Z )-3-(5-甲基-2-丙基苯基)-4-氧噻唑亞烷-2-基))-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F45) 製備為白色固體(0.040g，63%)。(Z )-1-(3-(2- 乙氧基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F8) From 1-(( Z )-3-(5-methyl-2-propylphenyl)-4-oxothazol-2-yl))-3-(4-(( E )-2-() 1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) ethenyl) phenyl) urea (F45) was prepared as a white solid (0.040g, 63%). (Z) -1- (3- (2- ethoxy-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (4- ( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F8)

從1-((Z )-3-(2-乙氧基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F46) 製備為白色固體 (0.031g，65%)。(Z )-1-(3-(4- 氟-2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F9) From 1-(( Z )-3-(2-ethoxy-5-methylphenyl)-4-oxothazol-2-yl)-3-(4-(( E )-2-( 1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F46) was obtained as a white solid (0.031 g, 65%). (Z) -1- (3- (4- Fluoro-2-isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1 -(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F9)

從1-((Z)-3-(4-氟-2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E)-2-(1-(4-(三氟甲氧基)苯基)-1H-1,2,4-三唑-3-基)乙烯基)苯基)脲(F47) 製備為白色固體(0.047g，64%)。(Z )-1-(3-(2-( 二級丁氧基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F10) From 1-((Z)-3-(4-fluoro-2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)-3-(4-((E) 2-(1-(4-(Trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)vinyl)phenyl)urea (F47) was prepared as a white solid ( 0.047 g, 64%). (Z) -1- (3- (2- ( two-butoxy) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1 -(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F10)

從1-((Z )-3-(2-(二級丁氧基)-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F48) 製備為白色固體(0.057g，71%)。(Z )-1-(3-(2- 異丙氧基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F11) From 1 - ((Z) -3- ( 2- ( two-butoxy) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) 2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F48) was prepared as a white solid (0.057 g, 71%). (Z) -1- (3- (2- isopropoxy-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (4 -( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F11)

從1-((Z )-3-(2-異丙氧基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F49) 製備為白色固體(0.054g，68%)。(Z )-1-(3-(5- 甲基-2-( 三氟甲氧基) 苯基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F12) From 1-(( Z )-3-(2-isopropoxy-5-methylphenyl)-4-oxothazol-2-yl)-3-(4-(( E )-2- (1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F49) was obtained as a white solid (0.054 g , 68%). ( Z )-1-(3-(5 -methyl-2-( trifluoromethoxy) phenyl)-4 -oxothazol-2- yl)-3-(4-(2-(1) -(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F12)

從1-((Z )-3-(5-甲基-2-(三氟甲氧基)苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F50) 製備為白色固體 (0.064g，69%)。(Z )-1-(3-(5- 甲基-2-(2,2,2- 三氟乙氧基) 苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F13) From 1-(( Z )-3-(5-methyl-2-(trifluoromethoxy)phenyl)-4-oxothazol-2-yl)-3-(4-(( E ) 2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F50) was prepared as a white solid (0.064 g, 69%). (Z) -1- (3- (5- methyl-2- (2,2,2-trifluoroethoxy) phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 -(2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F13)

從1-((Z )-3-(5-甲基-2-(2,2,2-三氟乙氧基)苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F51) 製備為白色固體 (0.077g，81%)。(Z )-1-(3-(2-( 三 級丁氧基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F14) From 1-(( Z )-3-(5-methyl-2-(2,2,2-trifluoroethoxy)phenyl)-4-oxoththiazin-2-yl)-3-( 4 - ((E) -2- ( 1- (4- ( trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) ethenyl) phenyl) urea ( F51) Prepared as a white solid (0.077 g, 81%). (Z) -1- (3- (2- ( three-butoxy) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1 -(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F14)

從1-((Z )-3-(2-(三級丁氧基)-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F52) 製備為灰白色固體(0.070g，74%)。甲基 (Z )-2-(3-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲基)-5-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯甲酸酯(F16) From 1 - ((Z) -3- ( 2- ( three-butoxy) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4 - ((E ) 2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F52) was prepared as an off-white solid (0.070 g, 74%). Methyl (Z) -2- (3- (3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) ureido) -5- (2- ( 1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) benzoate (F16)

從甲基 2-(3-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)脲基)-5-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯甲酸酯(F54) 製備(0.044g，58%)。(Z )-1-(2- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基)-3-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F17) From methyl 2-(3-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxathiazolidine-2-yl)ureido)-5-(( E Preparation of 2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)benzoate (F54) (0.044 g, 58%). (Z) -1- (2- fluoro-4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) acetate yl) phenyl) -3- (3- (2-isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F17)

從1-(2-氟-4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基))-3-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)脲(F55) 製備(0.040g，56%)。(Z )-1-(2- 氯-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基)-3-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲 (F18) From 1-(2-fluoro-4-(( E )-2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl) Preparation of vinyl)phenyl))-3-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)urea (F55) (0.040) g, 56%). (Z) -1- (2- chloro-4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) acetate yl) phenyl) -3- (3- (2-isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F18)

從1-(2-氯-4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)-3-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)脲(F56) 製備(0.043g，71%)。(Z )-1-(2,6- 二氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基)-3-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲 (F19) From 1-(2-chloro-4-(( E )-2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl) Preparation of vinyl)phenyl)-3-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)urea (F56) (0.043g , 71%). ( Z )-1-(2,6 -Difluoro-4-(2-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazole-3- yl) ethyl) phenyl) -3- (3- (2-isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F19)

從1-(2,6-二氟-4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)-3-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)脲(F57) 製備且單離為白色固體(0.046g，58%)。(Z )-1-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(2- 甲氧基-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F20) From 1-(2,6-difluoro-4-(( E )-2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazole-3 Preparation of -yl)vinyl)phenyl)-3-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)urea (F57) And isolated as a white solid (0.046 g, 58%). (Z) -1- (3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (2-methoxy-4- (2- (1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F20)

從1-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(2甲氧基-4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F58) 製備(0.040g，67%)。(Z )-1-(3- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基)-3-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F23) From 1-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)-3-(2methoxy-4-(( E) Preparation of 2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F58) (0.040 g, 67%). (Z) -1- (3- fluoro-4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) acetate yl) phenyl) -3- (3- (2-isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F23)

從1-(3-氟-4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)-3-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)脲(F61) 製備且單離為灰白色固體(0.046g，63%)。(Z )-1-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基)-2-( 三氟甲基) 苯基) 脲(F25) From 1-(3-fluoro-4-(( E )-2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl) Preparation of vinyl)phenyl)-3-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)urea (F61) It was an off-white solid (0.046 g, 63%). (Z) -1- (3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (4- ( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl)-2-( trifluoromethyl) phenyl) urea (F25)

從1-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)-2-(三氟甲基)苯基)脲(F62) 製備(0.040g，55%)。(Z )-1-(2- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基)-3-(3-(2- 異丙基-5-( 三氟甲基) 苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F27) From 1-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)-3-(4-(( E )-2-( 1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)-2-(trifluoromethyl)phenyl)urea (F62 ) Preparation (0.040 g, 55%). (Z) -1- (2- fluoro-4- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) acetate yl) phenyl) -3- (3- (2-isopropyl-5- (trifluoromethyl) phenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F27)

從1-(2-氟-4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)-3-((Z )-3-(2-異丙基-5-(三氟甲基)苯基)-4-氧噻唑亞烷-2-基)脲(F64) 製備為灰白色固體(0.059g，79%)。(Z )-1-(3-(2- 異丙基-5-( 三氟甲基) 苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F29) From 1-(2-fluoro-4-(( E )-2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl) Vinyl)phenyl)-3-(( Z )-3-(2-isopropyl-5-(trifluoromethyl)phenyl)-4-oxothazolidine-2-yl)urea (F64) Prepared as an off-white solid (0.059 g, 79%). (Z) -1- (3- (2- isopropyl-5- (trifluoromethyl) phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1 -(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F29)

從1-((Z )-3-(2-異丙基-5-(三氟甲基)苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F65) 製備為灰白色固體(0.057g，72%)。(Z )-1-(3-(2-(2,2- 二氟環丙基)-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(2- 氟-4-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F30) From 1-(( Z )-3-(2-isopropyl-5-(trifluoromethyl)phenyl)-4-oxothazol-2-yl)-3-(4-(( E ) 2-(1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F65) was prepared as an off-white solid (0.057 g, 72%). (Z) -1- (3- (2- (2,2- difluoro-cyclopropyl) -5-methyl-phenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (2-fluoro -4-(2-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F30)

從1-((Z )-3-(2-(2,2-二氟環丙基)-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(2-氟-4-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F67) 製備為灰白色固體(0.057g，72%)。(Z )-1-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(5-(2-(1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑-3- 基) 乙基) 吡啶-2- 基) 脲(F32) From 1-(( Z )-3-(2-(2,2-difluorocyclopropyl)-5-methylphenyl)-4-oxoththiazin-2-yl)-3-(2- Fluoro-4-(( E )-2-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl) Urea (F67) was prepared as an off-white solid (0.057 g, 72%). (Z) -1- (3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (5- (2- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) ethyl) pyridin-2-yl) urea (F32)

從1-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(5-((E )-2-(1-(4-(三氟甲氧基)苯基)-1H -1,2,4-三唑-3-基)乙烯基)吡啶-2-基)脲(F70) 製備且單離為灰白色固體(0.032g，64%)。(Z )-1-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(5-(2-(1-(5-( 三氟甲氧基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙基) 吡啶-2- 基) 脲(F33) From 1-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)-3-(5-(( E )-2-() 1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)vinyl)pyridin-2-yl)urea (F70) was prepared and isolated Off-white solid (0.032 g, 64%). (Z) -1- (3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (5- (2- (l- (5- ( trifluoromethoxy) pyridin-2- yl)-1 H -1,2,4- triazol-3 -yl) ethyl) pyridin-2- yl) urea (F33)

從1-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(5-((E )-2-(1-(5-(三氟甲氧基)吡啶-2-基)-1H -1,2,4-三唑-3-基)乙烯基)吡啶-2-基)脲(F71) 、使用氧化鉑(IV)配於四氫呋喃來製備，且單離為灰白色固體(0.025g，50%)。(Z )-1-(4-(2-(1-(3- 氯-5-( 三氟甲基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基)-3-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基) 脲(F34) From 1-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)-3-(5-(( E )-2-() 1-(5-(Trifluoromethoxy)pyridin-2-yl)-1 H -1,2,4-triazol-3-yl)vinyl)pyridin-2-yl)urea (F71) , used Platinum (IV) oxide was prepared in tetrahydrofuran and isolated as an off-white solid (0.025 g, 50%). (Z) -1- (4- (2- (1- (3- chloro-5- (trifluoromethyl) pyridin-2-yl) -1 H -1,2,4- triazol-3-yl ) ethyl) phenyl) -3- (3- (2-isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) urea (F34)

從1-(4-((E )-2-(1-(3-氯-5-(三氟甲基)吡啶-2-基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)-3-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)脲(F72) 、氧化鉑(IV)配於四氫呋喃來製備(0.100g，66%)。(Z )-1-(3-(2- 異丙基-5- 甲基苯 基)-4- 氧噻唑亞烷-2- 基)-3-(4-(2-(1-(5-( 三氟甲氧基) 吡啶-2- 基)-1H -1,2,4- 三唑-3- 基) 乙基) 苯基) 脲(F74) From 1-(4-(( E )-2-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1 H -1,2,4-triazole-3- Vinyl)phenyl)-3-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazolidine-2-yl)urea (F72) , oxidized Platinum (IV) was prepared in tetrahydrofuran (0.100 g, 66%). (Z) -1- (3- (2- isopropyl-5-methylphenyl) -4-oxo-2-thiazol-alkylene-yl) -3- (4- (2- (1- (5- ( trifluoromethoxy) pyridin-2- yl)-1 H -1,2,4- triazol-3 -yl) ethyl) phenyl) urea (F74)

從1-((Z )-3-(2-異丙基-5-甲基苯基)-4-氧噻唑亞烷-2-基)-3-(4-((E )-2-(1-(5-(三氟甲氧基)吡啶-2-基)-1H -1,2,4-三唑-3-基)乙烯基)苯基)脲(F69) 製備且單離為淡棕色固體(0.095g，79%)。實施例12 ：3-(4- 硝基苯基) 丙醯胺(C35) 之製備 From 1-(( Z )-3-(2-isopropyl-5-methylphenyl)-4-oxothazol-2-yl)-3-(4-(( E )-2-( 1-(5-(Trifluoromethoxy)pyridin-2-yl)-1 H -1,2,4-triazol-3-yl)vinyl)phenyl)urea (F69) was prepared and isolated Light brown solid (0.095 g, 79%). Example 12 : Preparation of 3-(4- nitrophenyl) propanamide (C35)

將3-(4-硝基苯基)丙酸(10.0g，51.2 mmol)及甲苯(203 mL)添加至100 mL燒瓶。添加亞硫醯氯(4.11 mL，56.4 mmol)及N,N -二甲基甲醯胺(2.03 mL)。反應係於預熱至70 ℃之加熱組內攪拌。5小時之後，添加額外亞硫醯氯之等分試樣(1.20 mL，16.5 mmol)。允許反應混合物於70℃下攪拌過夜。讓反應混合物濃縮。生成的殘餘物係用四氫噻喃(100 mL)來稀釋，並且添加氫氧化銨(10.0 mL，257 mmol)。允許反應於室溫下攪拌歷時4小時。讓反應濃縮，以及殘餘物係經由急速管柱層析法予以純化，其係使用30-100%乙酸乙酯/己烷作為沖提液，以提供標題化合物(6.65g，66%)：1 H NMR (400 MHz, DMSO-d6 ) δ 8.19 - 8.12 (m, 2H), 7.55 - 7.45 (m, 2H), 7.33 (s, 1H), 6.82 (s, 1H), 2.94 (t,J = 7.6 Hz, 2H), 2.42 (t,J = 7.6 Hz, 2H)；13 C NMR (101 MHz, DMSO-d6 ) δ 172.81, 149.97, 145.84, 129.53, 123.32, 39.70, 35.73, 30.53；ESIMSm/z 195 ([M+H]+ )。3-(4-Nitrophenyl)propionic acid (10.0 g, 51.2 mmol) and toluene (203 mL) were added to a 100 mL flask. Thionium chloride (4.11 mL, 56.4 mmol) and N,N -dimethylformamide (2.03 mL) were added. The reaction was stirred in a heating group preheated to 70 °C. After 5 hours, an additional aliquot of sulfoxide chloride (1.20 mL, 16.5 mmol) was added. The reaction mixture was allowed to stir at 70 ° C overnight. The reaction mixture was concentrated. The resulting residue was diluted with tetrahydrothiopyran (100 mL) and ammonium hydroxide (10.0 mL, 257 mmol). The reaction was allowed to stir at room temperature for 4 hours. The reaction was concentrated, and the residue was purified by flash column be based chromatography, which system using 30-100% ethyl acetate / hexanes as eluent, to afford the title compound (6.65g, 66%): 1 H NMR (400 MHz, DMSO- d 6 ) δ 8.19 - 8.12 (m, 2H), 7.55 - 7.45 (m, 2H), 7.33 (s, 1H), 6.82 (s, 1H), 2.94 (t, J = 7.6 Hz, 2H), 2.42 (t, J = 7.6 Hz, 2H); 13 C NMR (101 MHz, DMSO- d 6 ) δ 172.81, 149.97, 145.84, 129.53, 123.32, 39.70, 35.73, 30.53; ESIMS m/z 195 ([M+H] + ).

下列化合物係以實施例 12 中概述之流程相似的方式予以製備：(E )-3-(4- 硝基苯基) 丙烯醯胺(C36) The following compounds were prepared in a similar manner to the procedure outlined in Example 12 : ( E )-3-(4- nitrophenyl )propenylamine (C36)

從(E )-3-(4-硝基苯基)丙烯酸製備(3.66g，70%)：1 H NMR (400 MHz, DMSO-d6 ) δ 8.31 - 8.20 (m, 2H), 7.92 - 7.78 (m, 2H), 7.68 (s, 1H), 7.53 (d,J = 15.9 Hz, 1H), 7.30 (s, 1H), 6.81 (d,J = 15.9 Hz, 1H)；13 C NMR (101 MHz, DMSO-d6 ) δ 165.90, 147.46, 141.47, 136.78, 128.55, 126.63, 124.04；ESIMSm/z 193 ([M+H]+ )。2-(4- 硝基苯基) 環丙烷甲醯胺(C37) Preparation from ( E )-3-(4-nitrophenyl)acrylic acid (3.66 g, 70%): 1 H NMR (400 MHz, DMSO- d 6 ) δ 8.31 - 8.20 (m, 2H), 7.92 - 7.78 (m, 2H), 7.68 (s, 1H), 7.53 (d, J = 15.9 Hz, 1H), 7.30 (s, 1H), 6.81 (d, J = 15.9 Hz, 1H); 13 C NMR (101 MHz , DMSO- d 6 ) δ 165.90, 147.46, 141.47, 136.78, 128.55, 126.63, 124.04; ESIMS m/z 193 ([M+H] + ). 2-(4- nitrophenyl) cyclopropanecarbamide (C37)

從2-(4-硝基苯基)環丙烷甲酸製備(0.680g，65%)：1 H NMR (400 MHz, DMSO-d6 ) δ 8.18 - 8.10 (m, 2H), 7.75 - 7.58 (m, 1H), 7.46 - 7.36 (m, 2H), 7.09 - 6.95 (m, 1H), 2.40 (ddd,J = 8.9, 6.0, 4.0 Hz, 1H), 2.06 - 1.92 (m, 1H), 1.52 - 1.41 (m, 1H), 1.35 (ddd,J = 8.4, 6.0, 4.1 Hz, 1H)；13 C NMR (101 MHz, DMSO-d6 ) δ 172.13, 150.11, 145.63, 126.78, 123.45, 26.72, 23.78, 16.33；ESIMSm/z 206 ([M+H]+ )。實施例13 ：3-(4- 硝基苯乙基)-1H -1,2,4- 三唑(C38) 之製備 Preparation from 2-(4-nitrophenyl)cyclopropanecarboxylic acid (0.680 g, 65%): 1 H NMR (400 MHz, DMSO- d 6 ) δ 8.18 - 8.10 (m, 2H), 7.75 - 7.58 (m , 1H), 7.46 - 7.36 (m, 2H), 7.09 - 6.95 (m, 1H), 2.40 (ddd, J = 8.9, 6.0, 4.0 Hz, 1H), 2.06 - 1.92 (m, 1H), 1.52 - 1.41 (m, 1H), 1.35 (ddd, J = 8.4, 6.0, 4.1 Hz, 1H); 13 C NMR (101 MHz, DMSO- d 6 ) δ 172.13, 150.11, 145.63, 126.78, 123.45, 26.72, 23.78, 16.33 ;ESIMS m/z 206 ([M+H] + ). Example 13 : Preparation of 3-(4- nitrophenethyl)-1 H -1,2,4- triazole (C38)

將3-(4-硝基苯基)丙醯胺(C35) (6.65g，34.2 mmol)及1,1-二甲氧基-N,N -二甲基甲胺(65.0 mL，489 mmol)添加至1000 mL燒瓶。反應混合物係加溫至80 ℃歷時4.5小時。反應係於冰浴內冷卻。生成的沈澱係經由過濾通過玻璃料來收集。將生成的固體裝入200 mL燒瓶，且以乙酸(68.5 mL)及水合肼(1.66 mL，34.2 mmol)予以稀釋。反應係加熱至100℃過夜。使反應冷卻至室溫，以及小心地用含水氫氧化鈉來中和至pH ~8.5。用乙酸乙酯(3 x 75 mL)來萃取生成的溶液。組合的有機層係於硫酸鎂上乾燥、過濾及濃縮，以提供標題化合物(6.80g，90%)：1 H NMR (400 MHz, DMSO-d6 ) δ 13.64 (s, 1H), 8.12 (dd,J = 9.4, 2.7 Hz, 3H), 7.57 - 7.41 (m, 2H), 3.15 (dd,J = 8.1, 6.3 Hz, 2H), 3.09 - 3.00 (m, 2H)；13 C NMR (101 MHz, DMSO-d6 ) δ 149.23, 145.93, 129.60, 123.31, 33.02, 27.50；ESIMSm/z 219 ([M+H]+ )。3-(4-Nitrophenyl)propanamide (C35) (6.65 g, 34.2 mmol) and 1,1-dimethoxy- N,N -dimethylmethylamine (65.0 mL, 489 mmol) Add to the 1000 mL flask. The reaction mixture was warmed to 80 °C for 4.5 hours. The reaction was cooled in an ice bath. The resulting precipitate was collected by filtration through a frit. The resulting solid was placed in a 200 mL flask and diluted with acetic acid (68.5 mL) and hydrazine hydrate (1.66 mL, 34.2 mmol). The reaction was heated to 100 ° C overnight. The reaction was allowed to cool to room temperature and carefully neutralized with aqueous sodium hydroxide to pH ~ 8.5. The resulting solution was extracted with ethyl acetate (3 x 75 mL). The organic layer was combined based on magnesium sulfate, filtered and concentrated to afford the title compound (6.80g, 90%): 1 H NMR (400 MHz, DMSO- d6) δ 13.64 (s, 1H), 8.12 (dd, J = 9.4, 2.7 Hz, 3H), 7.57 - 7.41 (m, 2H), 3.15 (dd, J = 8.1, 6.3 Hz, 2H), 3.09 - 3.00 (m, 2H); 13 C NMR (101 MHz, DMSO - d 6 ) δ 149.23, 145.93, 129.60, 123.31, 33.02, 27.50; ESIMS m/z 219 ([M+H] + ).

下列化合物係以實施例 13 中概述之流程相似的方式予以製備：(E )-3-(4- 硝基苯乙烯基)-1H -1,2,4- 三唑(C39) The following compounds were prepared in a similar manner to the procedure outlined in Example 13 : ( E )-3-(4 -nitrostyryl)-1 H -1,2,4- triazole (C39)

從(E )-3-(4-硝基苯基)丙烯醯胺(C36) 製備(3.01g，72%)：1 H NMR (400 MHz, DMSO-d6 ) δ 8.46 (s, 1H), 8.28 - 8.17 (m, 2H), 8.01 - 7.89 (m, 2H), 7.61 (d,J = 16.3 Hz, 1H), 7.45 (d,J = 16.3 Hz, 1H)；13 C NMR (101 MHz, DMSO-d6 ) δ 158.06, 146.69, 146.35, 142.83, 130.48, 127.83, 123.95, 121.86；ESIMSm/z 217 ([M+H]+ )。3-(2-(4- 硝基苯基) 環丙基)-1H -1,2,4- 三唑(C40) Prepared from ( E )-3-(4-nitrophenyl)propenylamine ( C36) (3.01 g, 72%): 1 H NMR (400 MHz, DMSO- d 6 ) δ 8.46 (s, 1H), 8.28 - 8.17 (m, 2H), 8.01 - 7.89 (m, 2H), 7.61 (d, J = 16.3 Hz, 1H), 7.45 (d, J = 16.3 Hz, 1H); 13 C NMR (101 MHz, DMSO - d 6 ) δ 158.06, 146.69, 146.35, 142.83, 130.48, 127.83, 123.95, 121.86; ESIMS m/z 217 ([M+H] + ). 3-(2-(4- nitrophenyl) cyclopropyl)-1 H -1,2,4- triazole (C40)

從2-(4-硝基苯基)環丙烷甲醯胺(C36) 製備(0.342g，45%)：1 H NMR (400 MHz, DMSO-d6 ) δ 13.76 (s, 1H), 8.43 (s, 1H), 8.15 (d,J = 8.6 Hz, 2H), 7.49 (d,J = 8.4 Hz, 2H), 2.55 (s, 1H), 2.50 - 2.45 (m, 1H), 1.71 (s, 2H)；ESIMSm/z 230 ([M+H]+ )。實施例14 ：3-(4- 硝基苯乙基)-1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑(C41) 之製備 Prepared from 2-(4-nitrophenyl)cyclopropanecarbamide (C36) (0.342 g, 45%): 1 H NMR (400 MHz, DMSO- d 6 ) δ 13.76 (s, 1H), 8.43 ( s, 1H), 8.15 (d, J = 8.6 Hz, 2H), 7.49 (d, J = 8.4 Hz, 2H), 2.55 (s, 1H), 2.50 - 2.45 (m, 1H), 1.71 (s, 2H ); ESIMS m/z 230 ([M+H] + ). Example 14 : Preparation of 3-(4- nitrophenethyl)-1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazole (C41)

將3-(4-硝基苯乙基)-1H -1,2,4-三唑(C38) (6.50g，29.8 mmol)、碳酸鉀(8.23g，59.6 mmol)及氯化銅(I) (0.590g，5.96 mmol) 添加至100 mL燒瓶。將燒瓶密封且放置於惰性氛圍下，繼而添加N,N -二甲基甲醯胺(99 mL)、N 1,N 2-二甲基乙烷-1,2-二胺(1.28 mL，11.9 mmol)，及1-碘-4-(三氟甲氧基)苯(6.99 mL，44.7 mmol)。反應係於加溫至100 ℃之加熱組內攪拌過夜。使反應冷卻至室溫，且倒至鹽水溶液內。用乙酸乙酯(3 x 100 mL)來萃取水層。合併之有機層係於硫酸鎂上乾燥、過濾以及濃縮。生成的殘餘物係經由急速管柱層析法予以純化，其係使用0-70%乙酸乙酯/己烷作為沖提液，以提供標題化合物(8.97g，79%)：1 H NMR (400 MHz, DMSO-d6 ) δ 9.23 (s, 1H), 8.21 - 8.07 (m, 2H), 7.99 - 7.87 (m, 2H), 7.55 (dd,J = 8.8, 1.8 Hz, 4H), 3.20 (dd,J = 8.2, 6.2 Hz, 2H), 3.15 - 3.04 (m, 2H)；19 F NMR (376 MHz, DMSO-d6 ) δ -57.06；13 C NMR (101 MHz, DMSO-d6 ) δ 163.73, 149.34, 146.85, 145.93, 142.91, 135.61, 129.69, 123.81, 123.30, 122.46, 121.26, 120.76, 118.71, 116.14, 32.94, 28.62；ESIMSm/z 379 ([M+H]+ )。3-(4-Nitrophenylethyl)-1 H -1,2,4-triazole (C38) (6.50 g, 29.8 mmol), potassium carbonate (8.23 g, 59.6 mmol) and copper chloride (I) (0.590 g, 5.96 mmol) was added to a 100 mL flask. The flask was sealed and placed under an inert atmosphere, followed by the addition of N,N -dimethylformamide (99 mL), N 1, N 2-dimethylethane-1,2-diamine (1.28 mL, 11.9 Methyl), and 1-iodo-4-(trifluoromethoxy)benzene (6.99 mL, 44.7 mmol). The reaction was stirred overnight in a heating group warmed to 100 °C. The reaction was allowed to cool to room temperature and poured into a brine solution. The aqueous layer was extracted with ethyl acetate (3 x 100 mL). The combined organic layers were dried over MgSO4, filtered and concentrated. Be generated based residue was purified via flash column chromatography, which is based 0-70% ethyl acetate / hexanes as eluent, to afford the title compound (8.97g, 79%): 1 H NMR (400 MHz, DMSO- d 6 ) δ 9.23 (s, 1H), 8.21 - 8.07 (m, 2H), 7.99 - 7.87 (m, 2H), 7.55 (dd, J = 8.8, 1.8 Hz, 4H), 3.20 (dd , J = 8.2, 6.2 Hz, 2H), 3.15 - 3.04 (m, 2H); 19 F NMR (376 MHz, DMSO- d 6 ) δ -57.06; 13 C NMR (101 MHz, DMSO- d 6 ) δ 163.73 , 149.34, 146.85, 145.93, 142.91, 135.61, 129.69, 123.81, 123.30, 122.46, 121.26, 120.76, 118.71, 116.14, 32.94, 28.62; ESIMS m/z 379 ([M+H] + ).

下列化合物係以實施例 14 中概述之流程相似的方式予以製備：(E )-3-(4- 硝基苯乙烯基)-1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑(C42) The following compounds were prepared in a similar manner to the procedure outlined in Example 14 : ( E )-3-(4 -nitrostyryl)-1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazole (C42)

從(E )-3-(4-硝基苯乙烯基)-1H -1,2,4-三唑(C39) 製備(3.12g，59%)：1 H NMR (400 MHz, DMSO-d6 ) δ 9.39 (s, 1H), 8.26 - 8.18 (m, 2H), 8.06 - 7.96 (m, 4H), 7.71 (d,J = 16.2 Hz, 1H), 7.64 - 7.57 (m, 2H), 7.53 (d,J = 16.3 Hz, 1H)；19 F NMR (376 MHz, DMSO-d6 ) δ -57.01；13 C NMR (101 MHz, DMSO-d6 ) δ 161.24, 147.09, 146.84, 143.64, 142.52, 135.50, 131.92, 128.07, 123.90, 122.53, 121.85, 120.96；ESIMSm/z 377 ([M+H]+ )。3-(2-(4- 硝基苯基) 環丙基)-1-(4-( 三氟甲氧基) 苯基)-1H -1,2,4- 三唑(C43) Preparation of ( E )-3-(4-nitrostyryl)-1 H -1,2,4-triazole (C39) (3.12 g, 59%): 1 H NMR (400 MHz, DMSO- d 6 ) δ 9.39 (s, 1H), 8.26 - 8.18 (m, 2H), 8.06 - 7.96 (m, 4H), 7.71 (d, J = 16.2 Hz, 1H), 7.64 - 7.57 (m, 2H), 7.53 (d, J = 16.3 Hz, 1H); 19 F NMR (376 MHz, DMSO- d 6 ) δ -57.01; 13 C NMR (101 MHz, DMSO- d 6 ) δ 161.24, 147.09, 146.84, 143.64, 142.52, 135.50, 131.92, 128.07, 123.90, 122.53, 121.85, 120.96; ESIMS m/z 377 ([M+H] + ). 3-(2-(4- Nitrophenyl) cyclopropyl)-1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazole (C43)

從3-(2-(4-硝基苯基)環丙基)-1H -1,2,4-三唑(C38) 、使用碘化銅(I)及碳酸銫(0.080g，14%)來製備：1 H NMR (400 MHz, DMSO-d6 ) δ 9.24 (s, 1H), 8.20 - 8.12 (m, 2H), 8.01 - 7.93 (m, 2H), 7.63 - 7.55 (m, 2H), 7.55 - 7.48 (m, 2H), 2.69 - 2.56 (m, 2H), 1.77 (ddd,J = 8.7, 6.0, 4.6 Hz, 1H), 1.66 (ddd,J = 8.8, 6.0, 4.7 Hz, 1H)；19 F NMR (376 MHz, DMSO-d6 ) δ -56.98；ESIMSm/z 391 ([M+H]+ )。實施例15 ：乙基N -[(2- 異丙基-5- 甲基- 苯 基) 硫代胺甲醯基] 胺甲酸酯(C44) 之製備 From 3-(2-(4-nitrophenyl)cyclopropyl)-1 H -1,2,4-triazole (C38) , using copper (I) iodide and cesium carbonate (0.080 g, 14%) To prepare: 1 H NMR (400 MHz, DMSO- d 6 ) δ 9.24 (s, 1H), 8.20 - 8.12 (m, 2H), 8.01 - 7.93 (m, 2H), 7.63 - 7.55 (m, 2H) , 7.55 - 7.48 (m, 2H), 2.69 - 2.56 (m, 2H), 1.77 (ddd, J = 8.7, 6.0, 4.6 Hz, 1H), 1.66 (ddd, J = 8.8, 6.0, 4.7 Hz, 1H) 19 F NMR (376 MHz, DMSO- d 6 ) δ - 56.98; ESIMS m/z 391 ([M+H] + ). Example 15: Ethyl N - amine carboxylate (reacting C44) - A [thio carbamoyl acyl (2-isopropyl-5-phenyl-methyl)]

將2-異丙基-5-甲基苯胺(6.30g，42.2 mmol)及二乙基醚(40 mL)添加至反應燒瓶。於30分鐘期間緩慢地添加氯甲酸乙酯(5.54g，42.2 mmol)至反應混合物。添加己烷(50 mL)至反應混合物，反應混合物繼而冷卻至室溫10 ℃。將所得固體過濾以及風乾，以提供如棕褐色固體之標題化合物(9.34g，77%)：mp 135-137 ℃；1 H NMR (400 MHz, CDCl3 ) δ 11.05 (s, 1H), 8.14 (s, 1H), 7.34 - 7.21 (m, 2H), 7.20 - 7.09 (m, 1H), 4.30 (q,J = 7.1 Hz, 2H), 3.10 - 2.94 (m, 1H), 2.34 (s, 3H), 1.36 (t,J = 7.1 Hz, 3H), 1.23 (d,J = 6.9 Hz, 6H)；ESIMSm/z 281 ([M+H]+ )。實施例16 ：乙基 (Z )-(3-(2- 異丙基-5- 甲基苯 基) 噻唑-2(3H )- 亞基) 胺甲酸酯(C45) 之製備 2-Isopropyl-5-methylaniline (6.30 g, 42.2 mmol) and diethyl ether (40 mL) were added to the reaction flask. Ethyl chloroformate (5.54 g, 42.2 mmol) was slowly added to the reaction mixture over 30 min. Hexane (50 mL) was added to the reaction mixture, which was then cooled to room temperature 10 °C. The resulting solid was filtered and air dried to provide a tan solid as the title compound (9.34g, 77%): mp 135-137 ℃; 1 H NMR (400 MHz, CDCl 3) δ 11.05 (s, 1H), 8.14 ( s, 1H), 7.34 - 7.21 (m, 2H), 7.20 - 7.09 (m, 1H), 4.30 (q, J = 7.1 Hz, 2H), 3.10 - 2.94 (m, 1H), 2.34 (s, 3H) , 1.36 (t, J = 7.1 Hz, 3H), 1.23 (d, J = 6.9 Hz, 6H); ESIMS m/z 281 ([M+H] + ). Example 16: ethyl (Z) - amine carboxylate (C45) - A (subunit 3- (2-isopropyl-5-methylphenyl) thiazol -2 (3 H))

將乙基N -[(2-異丙基-5-甲基-苯基)硫代胺甲醯基]胺甲酸酯(C44) (7.00g，26.0 mmol)、乙腈(80 mL)及碳酸銫(13.8g，42.4 mmol)添加至反應燒瓶。允許反應混合物於室溫下攪拌。2-氯乙醛(5.10g，32.5 mmol)係於40分鐘期間以0.5 mL的增量添加至反應混合物，使溫度維持低於30 ℃。反應混合物係以二乙基醚(100 mL)稀釋，並以飽和的含水碳酸氫鈉(100 mL)予以清洗。將層予以分離，以及有機物係用鹽水(50 mL)清洗，於硫酸鎂上乾燥、過濾以及濃縮以提供紅色油。將油溶解於乾燥的四氫呋喃(75 mL)內，繼而於冰浴內冷卻。添加N,N -二異丙基乙胺(8.07g， 62.4 mmol)，接著逐滴地添加亞硫醯氯(2.97g，25.0 mmol)，使溫度維持低於15 ℃。允許反應混合物攪拌歷時1小時。反應係以二乙基醚(100 mL)稀釋，並以飽和的含水碳酸氫鈉(100 mL)予以清洗。將層予以分離，以及有機物係於硫酸鎂上乾燥、過濾以及於30 g矽膠上濃縮。藉由急速管柱層析法予以純化，其係使用0-50%乙酸乙酯/己烷作為沖提液，提供如黃色固體之標題化合物(4.24g，55%)：mp 119-123 ℃；1 H NMR (400 MHz, CDCl3 ) δ 7.31 (d,J = 8.0 Hz, 1H), 7.23 (dd,J = 8.0, 1.8 Hz, 1H), 6.98 (dd,J = 1.8, 0.9 Hz, 1H), 6.83 (d,J = 4.7 Hz, 1H), 6.66 (d,J = 4.7 Hz, 1H), 4.19 (q,J = 7.1 Hz, 2H), 2.57 (p,J = 6.9 Hz, 1H), 2.33 (s, 3H), 1.27 (t,J = 7.1 Hz, 3H), 1.20 (d,J = 6.8 Hz, 3H), 1.10 (d,J = 6.9 Hz, 3H)；ESIMSm/z 305 ([M+H]+ )。實施例17 ：3-(2- 異丙基-5- 甲基苯 基) 噻唑-2(3H )- 亞胺 (C46) 之製備 Ethyl N -[(2-isopropyl-5-methyl-phenyl)thiocarbamoyl]carbamate (C44) (7.00 g, 26.0 mmol), acetonitrile (80 mL) Rhodium (13.8 g, 42.4 mmol) was added to the reaction flask. The reaction mixture was allowed to stir at room temperature. 2-Chloroacetaldehyde (5.10 g, 32.5 mmol) was added to the reaction mixture in 0.5 mL increments over 40 min to maintain the temperature below 30 °C. The reaction mixture was diluted with diethyl ether (100 mL) and washed with saturated aqueous sodium hydrogen carbonate (100 mL). The layers were separated and the organic was washed with brine (50 mL). The oil was dissolved in dry tetrahydrofuran (75 mL) and then cooled in an ice bath. N,N -Diisopropylethylamine (8.07 g, 62.4 mmol) was added, followed by the dropwise addition of sulfinium chloride (2.97 g, 25.0 mmol) to maintain the temperature below 15 °C. The reaction mixture was allowed to stir for 1 hour. The reaction was diluted with diethyl ether (100 mL) and washed with saturated aqueous sodium hydrogen carbonate (100 mL). The layers were separated and the organics were dried over magnesium sulfate, filtered and concentrated on 30 g. Purification by flash column chromatography using EtOAc EtOAc (EtOAc: EtOAc: 1 H NMR (400 MHz, CDCl 3 ) δ 7.31 (d, J = 8.0 Hz, 1H), 7.23 (dd, J = 8.0, 1.8 Hz, 1H), 6.98 (dd, J = 1.8, 0.9 Hz, 1H) , 6.83 (d, J = 4.7 Hz, 1H), 6.66 (d, J = 4.7 Hz, 1H), 4.19 (q, J = 7.1 Hz, 2H), 2.57 (p, J = 6.9 Hz, 1H), 2.33 (s, 3H), 1.27 (t, J = 7.1 Hz, 3H), 1.20 (d, J = 6.8 Hz, 3H), 1.10 (d, J = 6.9 Hz, 3H); ESIMS m/z 305 ([M +H] + ). Example 17: 3- (2-isopropyl-5-methylphenyl) thiazol -2 (3 H) - Preparation of imine (C46 in) of

使乙基 (Z )-(3-(2-異丙基-5-甲基苯基)噻唑-2(3H)-亞基)胺甲酸酯(C45) (2.0g，6.6 mmol)係溶解於乙醇(20 mL)內且用固態氫氧化鈉(1.0g，26 mmol)來處理，以及攪拌溶液且加熱至65℃歷時6小時。使反應混合物冷卻至室溫，以及用水(100 mL)來稀釋。混合物係用二氯甲烷予以萃取、乾燥、過濾以及濃縮。藉由急速管柱層析法予以純化，其係使用0-100%乙酸乙酯/己烷作為沖提液，提供如棕褐色固體之標題化合物(1.0g，66%)：mp 56-59 ℃；1 H NMR (400 MHz, CDCl3 ) δ 7.32 (d,J = 8.0 Hz, 1H), 7.27 – 7.19 (m, 1H), 7.09 – 6.99 (m, 1H), 6.37 (d,J = 5.0 Hz, 1H), 5.89 (d,J = 4.9 Hz, 1H), 2.94 (p,J = 6.9 Hz, 1H), 2.34 (s, 4H), 1.23 (d,J = 6.8 Hz, 3H), 1.16 (d,J = 6.9 Hz, 3H)。實施例18 ：1- 氟-2- 甲基-4- 硝基-5-( 丙-1- 烯-2- 基) 苯(C47) 之製備 Ethyl ( Z )-(3-(2-isopropyl-5-methylphenyl)thiazole-2(3H)-ylidene) carbamate (C45) (2.0 g, 6.6 mmol) was dissolved Treatment with ethanol (20 mL) and solid sodium hydroxide (1.0 g, 26 mmol), and stirring the solution and heating to 65 ° C for 6 hours. The reaction mixture was cooled to room temperature and diluted with water (100 mL). The mixture was extracted with dichloromethane, dried, filtered and concentrated. Purification by flash column chromatography using 0-100% EtOAc / EtOAc (EtOAc) ; 1 H NMR (400 MHz, CDCl 3 ) δ 7.32 (d, J = 8.0 Hz, 1H), 7.27 – 7.19 (m, 1H), 7.09 – 6.99 (m, 1H), 6.37 (d, J = 5.0 Hz , 1H), 5.89 (d, J = 4.9 Hz, 1H), 2.94 (p, J = 6.9 Hz, 1H), 2.34 (s, 4H), 1.23 (d, J = 6.8 Hz, 3H), 1.16 (d , J = 6.9 Hz, 3H). Example 18: Preparation of 1-fluoro-2-methyl-4-nitro-5- (prop-1 -en-2-yl) benzene (C47) of

將1-氯-5-氟-4-甲基-2-硝苯(1.50g，7.91 mmol)、4,4,5,5-四甲基-2-(丙-1-烯-2-基)-1,3,2-二戊硼烷(1.79 mL，9.50 mmol)、雙(三苯基膦)二氯化鈀(II) (0.444g，0.633 mmol)，以及碳酸鈉(1.01g，9.50 mmol)添加至反應小瓶。添加水(2.85 mL)及二烷(11.4 mL)。將小瓶加蓋，以及係於具有外部IR-感測器監測小瓶側的溫度之Biotage Initiator®微波反應器中，以140 ℃加熱歷時30分鐘。使反應冷卻至室溫，用乙酸乙酯來稀釋，以及用水來清洗。水層係以乙酸乙酯(3x)進一步萃取。組合的有機層係於硫酸鎂上乾燥、過濾及濃縮。藉由急速管柱層析法予以純化，其係用0-40%乙酸乙酯/己烷予以沖提，提供如黃色液體之標題化合物(1.42g，88%)：1 H NMR (400 MHz, CDCl3 ) δ 7.81 (dd,J = 7.0, 0.9 Hz, 1H), 6.95 (d,J = 9.4 Hz, 1H), 5.17 (t,J = 1.5 Hz, 1H), 4.97 - 4.86 (m, 1H), 2.33 (dd,J = 2.0, 0.8 Hz, 3H), 2.06 (dd,J = 1.6, 0.9 Hz, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -108.66；EIMSm/z 195 ([M]+ )。1-Chloro-5-fluoro-4-methyl-2-nitrobenzene (1.50 g, 7.91 mmol), 4,4,5,5-tetramethyl-2-(prop-1-en-2-yl) )-1,3,2-two Pentaborane (1.79 mL, 9.50 mmol), bis(triphenylphosphine)palladium(II) chloride (0.444 g, 0.633 mmol), and sodium carbonate (1.01 g, 9.50 mmol) were added to the reaction vial. Add water (2.85 mL) and two Alkane (11.4 mL). The vial was capped and attached to a Biotage Initiator® microwave reactor with external IR-sensor monitoring vial temperature and heated at 140 °C for 30 minutes. The reaction was cooled to room temperature, diluted with ethyl acetate and washed with water. The aqueous layer was further extracted with ethyl acetate (3x). The combined organic layers were dried over magnesium sulfate, filtered and concentrated. Be purified by flash column chromatography, which is based with 0-40% ethyl acetate / hexanes was eluted be provided the title compound as a yellow liquid (1.42g, 88%) as: 1 H NMR (400 MHz, CDCl 3 ) δ 7.81 (dd, J = 7.0, 0.9 Hz, 1H), 6.95 (d, J = 9.4 Hz, 1H), 5.17 (t, J = 1.5 Hz, 1H), 4.97 - 4.86 (m, 1H) , 2.33 (dd, J = 2.0, 0.8 Hz, 3H), 2.06 (dd, J = 1.6, 0.9 Hz, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ -108.66; EIMS m/z 195 ([ M] + ).

下列化合物係以實施例 18 中概述之流程相似的方式予以製備：2- 硝基-1-( 丙-1- 烯-2- 基)-4-( 三氟甲基) 苯 (C48) The following compounds were prepared in a similar manner to the procedure outlined in Example 18 : 2- nitro-1-( prop-1 -en-2- yl)-4-( trifluoromethyl) benzene (C48)

從1-氯-2-硝基-4-(三氟甲基)苯製備為黃色油(0.428g，40%)：1 H NMR (500 MHz, CDCl3 ) δ 8.17 - 8.11 (m, 1H), 7.81 (ddd,J = 8.1, 1.9, 0.8 Hz, 1H), 7.49 (dd,J = 8.1, 0.9 Hz, 1H), 5.32 - 5.19 (m, 1H), 4.99 (t,J = 1.0 Hz, 1H), 2.11 (dd,J = 1.5, 0.9 Hz, 3H)；13 C NMR (126 MHz, CDCl3 ) δ 148.17, 142.52, 141.54, 131.54, 131.05, 130.78, 130.50, 130.23, 129.19, 129.16, 123.91, 121.74, 121.52, 121.49, 121.46, 121.42, 116.65, 23.06；19 F NMR (471 MHz, CDCl3 ) δ -62.86；EIMSm/z 231 ([M]+ )。實施例19 ：4- 氟-2- 異丙基-5- 甲基苯胺(C49) 之製備 Preparation of 1-chloro-2-nitro-4-(trifluoromethyl)benzene as a yellow oil (0.428 g, 40%): 1 H NMR (500 MHz, CDCl 3 ) δ 8.17 - 8.11 (m, 1H) , 7.81 (ddd, J = 8.1, 1.9, 0.8 Hz, 1H), 7.49 (dd, J = 8.1, 0.9 Hz, 1H), 5.32 - 5.19 (m, 1H), 4.99 (t, J = 1.0 Hz, 1H ), 2.11 (dd, J = 1.5, 0.9 Hz, 3H); 13 C NMR (126 MHz, CDCl 3 ) δ 148.17, 142.52, 141.54, 131.54, 131.05, 130.78, 130.50, 130.23, 129.19, 129.16, 123.91, 121.74 , 121.52, 121.49, 121.46, 121.42, 116.65, 23.06; 19 F NMR (471 MHz, CDCl 3 ) δ -62.86; EIMS m/z 231 ([M] + ). Example 19 : Preparation of 4- fluoro-2- isopropyl-5 -methylaniline (C49)

添加配於乙酸乙酯(29 mL)之1-氟-2-甲基-4-硝基-5-(丙-1-烯-2-基)苯(C47) (1.41g，7.22 mmol)添加附於碳上之鈀(10 重量%，0.770g，0.720 mmol) 添加至反應燒瓶。使燒瓶排氣，繼而用氫氣來重新填充(氣球) (3x)。反應混合物係於氫氣下以氣球予以攪拌過夜。反應混合物經Celite®予以過濾以及濃縮，以提供如黃色液體之標題化合物(1.10g，90%)：1 H NMR (400 MHz, CDCl3 ) δ 6.79 (d,J = 11.1 Hz, 1H), 6.49 (d,J = 7.0 Hz, 1H), 3.39 (s, 2H), 2.91 - 2.80 (m, 1H), 2.17 (d,J = 2.0 Hz, 3H), 1.22 (d,J = 6.8 Hz, 6H)；13 C NMR (101 MHz, CDCl3 ) δ 138.55, 122.03, 118.40, 118.35, 111.97, 111.73, 27.63, 22.29, 14.16；EIMSm/z 167 ([M]+ )。Add 1-fluoro-2-methyl-4-nitro-5-(prop-1-en-2-yl)benzene (C47) (1.41 g, 7.22 mmol) in ethyl acetate (29 mL) Palladium (10% by weight, 0.770 g, 0.720 mmol) attached to carbon was added to the reaction flask. The flask was vented and then refilled with hydrogen (balloon) (3x). The reaction mixture was stirred with a balloon under hydrogen overnight. The reaction mixture was filtered through Celite® and be concentrated to provide the title compound as a yellow liquid (1.10g, 90%): 1 H NMR (400 MHz, CDCl 3) δ 6.79 (d, J = 11.1 Hz, 1H), 6.49 (d, J = 7.0 Hz, 1H), 3.39 (s, 2H), 2.91 - 2.80 (m, 1H), 2.17 (d, J = 2.0 Hz, 3H), 1.22 (d, J = 6.8 Hz, 6H) 13 C NMR (101 MHz, CDCl 3 ) δ 138.55, 122.03, 118.40, 118.35, 111.97, 111.73, 27.63, 22.29, 14.16; EIMS m/z 167 ([M] + ).

下列化合物係以實施例 19 中概述之流程相似的方式予以製備：2- 異丙基-5-( 三氟甲基) 苯胺 (C50) The following compounds were prepared in a similar manner to the procedure outlined in Example 19 : 2- isopropyl-5-( trifluoromethyl) aniline (C50)

從2-硝基-1-(丙-1-烯-2-基)-4-(三氟甲基)苯(C48) 製備且單離為黃色油 (0.360g，99%)：1 H NMR (300 MHz, CDCl3 ) δ 7.22 (d,J = 8.0 Hz, 1H), 7.05 - 6.95 (m, 1H), 6.93 - 6.83 (m, 1H), 3.81 (s, 2H), 2.90 (p,J = 6.8 Hz, 1H), 1.27 (d,J = 6.8 Hz, 6H)；13 C NMR (126 MHz, CDCl3 ) δ 143.60, 135.99, 129.18, 128.93, 128.67, 128.42, 125.83, 125.40, 123.24, 115.39, 115.35, 112.01, 111.98, 27.73, 21.97；19 F NMR (471 MHz, CDCl3 ) δ -62.57；EIMSm/z 203 ([M]+ )。2-( 甲氧基甲基)-5- 甲基苯胺(C51) Prepared from 2-nitro-1-(prop-1-en-2-yl)-4-(trifluoromethyl)benzene (C48) and isolated as a yellow oil (0.360 g, 99%): 1 H NMR (300 MHz, CDCl 3 ) δ 7.22 (d, J = 8.0 Hz, 1H), 7.05 - 6.95 (m, 1H), 6.93 - 6.83 (m, 1H), 3.81 (s, 2H), 2.90 (p, J = 6.8 Hz, 1H), 1.27 (d, J = 6.8 Hz, 6H); 13 C NMR (126 MHz, CDCl 3 ) δ 143.60, 135.99, 129.18, 128.93, 128.67, 128.42, 125.83, 125.40, 123.24, 115.39, 115.35, 112.01, 111.98, 27.73, 21.97; 19 F NMR (471 MHz, CDCl 3 ) δ -62.57; EIMS m/z 203 ([M] + ). 2-( methoxymethyl)-5 -methylaniline (C51)

從1-(甲氧基甲基)-4-甲基-2-硝苯(C91) 製備且單離為橘色油(1.6g，100%)：1 H NMR (400 MHz, CDCl3 ) δ 6.94 (d,J = 7.3 Hz, 1H), 6.56 - 6.49 (m, 2H), 4.44 (s, 2H), 4.11 (s, 2H), 3.32 (s, 3H), 2.26 (s, 3H)；13 C NMR (101 MHz, CDCl3 ) δ 146.16, 139.28, 130.09, 119.27, 118.70, 116.44, 73.46, 57.26, 21.25；EIMSm/z 151 ([M]+ )。實施例20 ：2- 氯-N -(2- 氟-5- 甲基苯 基) 乙醯胺(C52) 之製備 Prepared from 1-(methoxymethyl)-4-methyl-2-nitrobenzene (C91) and isolated as orange oil (1.6 g, 100%): 1 H NMR (400 MHz, CDCl 3 ) δ 6.94 (d, J = 7.3 Hz, 1H), 6.56 - 6.49 (m, 2H), 4.44 (s, 2H), 4.11 (s, 2H), 3.32 (s, 3H), 2.26 (s, 3H); 13 C NMR (101 MHz, CDCl 3 ) δ 146.16, 139.28, 130.09, 119.27, 118.70, 116.44, 73.46, 57.26, 21.25; EIMS m/z 151 ([M] + ). Example 20: 2-Chloro - (2-fluoro-5-methylphenyl) acetyl amine (C52) of - N

將2-氟-5-甲基苯胺(3.00g，24.0 mmol)及乙酸乙酯(24.0 mL)添加至反應燒瓶。使反應冷卻至0℃。加入碳酸氫鈉(4.03g，47.9 mmol)，接著於4分鐘期間逐滴地添加氯乙醯氯(2.30 mL，28.8 mmol)。允許反應混合物於0℃下攪拌歷時10分鐘，然後允許反應加溫至室溫且進一步攪拌歷時90分鐘。將水(15 mL)添加至反應，以及使相分離。有機層係用鹽水(20 mL)清洗，於硫酸鎂上乾燥、過濾以及濃縮，以提供標題化合物(4.83g，100%)：1 H NMR (400 MHz, CDCl3 ) δ 8.47 (s, 1H), 8.08 (dd,J = 7.5, 2.1 Hz, 1H), 7.00 (dd,J = 10.7, 8.4 Hz, 1H), 6.90 (dddd,J = 8.3, 5.0, 2.2, 0.8 Hz, 1H), 4.21 (s, 2H), 2.34 (d,J = 0.9 Hz, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -135.59；13 C NMR (126 MHz, CDCl3 ) δ 163.83, 151.92, 150.00, 134.42, 125.79, 121.94, 114.64, 42.92, 21.08；ESIMSm/z 201 ([M+H]+ )。2-Fluoro-5-methylaniline (3.00 g, 24.0 mmol) and ethyl acetate (24.0 mL) were added to the reaction flask. The reaction was allowed to cool to 0 °C. Sodium bicarbonate (4.03 g, 47.9 mmol) was added followed by chloroethylamine (2.30 mL, 28.8 mmol). The reaction mixture was allowed to stir at 0<0>C for 10 min then allowed to warm to room temperature and further stirred over 90 min. Water (15 mL) was added to the reaction and the phases were separated. The organic layer was washed with brine-based (20 mL) washed, dried over magnesium sulfate, filtered and concentrated to afford the title compound (4.83g, 100%): 1 H NMR (400 MHz, CDCl 3) δ 8.47 (s, 1H) , 8.08 (dd, J = 7.5, 2.1 Hz, 1H), 7.00 (dd, J = 10.7, 8.4 Hz, 1H), 6.90 (dddd, J = 8.3, 5.0, 2.2, 0.8 Hz, 1H), 4.21 (s , 2H), 2.34 (d, J = 0.9 Hz, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ -135.59; 13 C NMR (126 MHz, CDCl 3 ) δ 163.83, 151.92, 150.00, 134.42, 125.79 , 121.94, 114.64, 42.92, 21.08; ESIMS m/z 201 ([M+H] + ).

下列化合物係以實施例 20 中概述之流程相似的方式予以製備：2- 氯-N -(2- 甲氧基-5- 甲基苯 基) 乙醯胺(C53) The following compounds were prepared in a similar system to be outlined in Example 20 of Scheme manner: 2-Chloro - N - (2- methoxy-5-methylphenyl) acetyl amine (C53)

從2-甲氧基-5-甲基苯胺製備且單離為棕色固體(4.50g，95%)：mp 78-80 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.90 (s, 1H), 8.16 (d,J = 2.1 Hz, 1H), 6.89 (ddd,J = 8.3, 2.1, 0.8 Hz, 1H), 6.79 (d,J = 8.3 Hz, 1H), 4.19 (s, 2H), 3.88 (s, 3H), 2.31 (s, 3H)；ESIMSm/z 213 ([M+H]+ )。2- 氯-N -(2- 乙氧基-5- 甲基苯 基) 乙醯胺(C54) Prepared from 2-methoxy-5-methylaniline and isolated as a brown solid (4.50 g, 95%): mp 78-80 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.90 (s, 1H) , 8.16 (d, J = 2.1 Hz, 1H), 6.89 (ddd, J = 8.3, 2.1, 0.8 Hz, 1H), 6.79 (d, J = 8.3 Hz, 1H), 4.19 (s, 2H), 3.88 ( s, 3H), 2.31 (s, 3H); ESIMS m/z 213 ([M+H] + ). 2-Chloro - N - (2- ethoxy-5-methylphenyl) acetyl amine (the C54)

從2-乙氧基-5-甲基苯胺製備且單離為黑色油(0.802g，100%)：mp 50-52 ℃；1 H NMR (400 MHz, CDCl3 ) δ 9.04 (s, 1H), 8.21 - 8.11 (m, 1H), 6.92 - 6.82 (m, 1H), 6.78 (d,J = 8.3 Hz, 1H), 4.20 (s, 2H), 4.08 (q,J = 7.0 Hz, 2H), 2.31 (t,J = 0.7 Hz, 3H), 1.45 (t,J = 7.0 Hz, 3H)；13 C NMR (126 MHz, CDCl3 ) δ 163.48, 145.61, 130.56, 126.54, 124.82, 120.09, 111.11, 64.54, 43.20, 20.97, 14.84；ESIMSm/z 227 ([M+H]+ )。2- 氯-N - (5- 甲基-2-( 三氟甲氧基) 苯基) 乙醯胺(C55) Prepared from 2-ethoxy-5-methylaniline and isolated as a black oil (0.802 g, 100%): mp 50-52 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 9.04 (s, 1H) , 8.21 - 8.11 (m, 1H), 6.92 - 6.82 (m, 1H), 6.78 (d, J = 8.3 Hz, 1H), 4.20 (s, 2H), 4.08 (q, J = 7.0 Hz, 2H), 2.31 (t, J = 0.7 Hz, 3H), 1.45 (t, J = 7.0 Hz, 3H); 13 C NMR (126 MHz, CDCl 3 ) δ 163.48, 145.61, 130.56, 126.54, 124.82, 120.09, 111.11, 64.54 , 43.20, 20.97, 14.84; ESIMS m/z 227 ([M+H] + ). 2- Chloro- N- (5 -methyl-2-( trifluoromethoxy) phenyl) acetamide (C55)

從5-甲基-2-(三氟甲氧基)苯胺製備且單離為白色固體 (1.33g，93%)：mp 86-88 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.68 (s, 1H), 8.19 (d,J = 2.1 Hz, 1H), 7.17 (dq,J = 8.4, 1.6 Hz, 1H), 7.02 - 6.90 (m, 1H), 4.22 (s, 2H), 2.37 (d,J = 0.7 Hz, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -58.04；ESIMSm/z 267 ([M+H]+ )。2- 氯-N -(2- 異丙氧基-5- 甲基苯 基) 乙醯胺(C56) Prepared from 5-methyl-2-(trifluoromethoxy)aniline and isolated as a white solid (1.33 g, 93%): mp 86-88 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.68 ( s, 1H), 8.19 (d, J = 2.1 Hz, 1H), 7.17 (dq, J = 8.4, 1.6 Hz, 1H), 7.02 - 6.90 (m, 1H), 4.22 (s, 2H), 2.37 (d , J = 0.7 Hz, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ -58.04; ESIMS m/z 267 ([M+H] + ). 2-Chloro - N - (2- isopropoxy-5-methylphenyl) acetyl amine (C56)

從2-異丙氧基-5-甲基苯胺製備且單離為棕色油(0.930g，97%)：1 H NMR (400 MHz, CDCl3 ) δ 9.11 (s, 1H), 8.17 (d,J = 2.0 Hz, 1H), 6.87 (ddq,J = 8.5, 2.1, 0.7 Hz, 1H), 6.81 (d,J = 8.3 Hz, 1H), 4.64 - 4.42 (m, 1H), 4.21 (s, 2H), 2.30 (d,J = 0.7 Hz, 3H), 1.36 (d,J = 6.0 Hz, 6H)；13 C NMR (126 MHz, CDCl3 ) δ 170.29, 163.68, 144.46, 130.78, 127.56, 124.93, 120.16, 113.28, 72.02, 43.21, 22.19, 21.00；ESIMSm/z 241 ([M+H]+ )。 N -(2-( 二級丁氧基)-5- 甲基苯 基 )-2- 氯乙醯胺(C57) Prepared from 2-isopropoxy-5-methylaniline and isolated as a brown oil (0.930 g, 97%): 1 H NMR (400 MHz, CDCl 3 ) δ 9.11 (s, 1H), 8.17 (d, J = 2.0 Hz, 1H), 6.87 (ddq, J = 8.5, 2.1, 0.7 Hz, 1H), 6.81 (d, J = 8.3 Hz, 1H), 4.64 - 4.42 (m, 1H), 4.21 (s, 2H ), 2.30 (d, J = 0.7 Hz, 3H), 1.36 (d, J = 6.0 Hz, 6H); 13 C NMR (126 MHz, CDCl 3 ) δ 170.29, 163.68, 144.46, 130.78, 127.56, 124.93, 120.16 , 113.28, 72.02, 43.21, 22.19, 21.00; ESIMS m/z 241 ([M+H] + ). N - (2- (two-butoxy) -5-methyl-phenyl) -2-chloro-acetyl-amine (of C57)

從2-(二級丁氧基)-5-甲基苯胺製備且單離為棕色油(0.600g，92%)：1 H NMR (400 MHz, CDCl3 ) δ 9.12 (s, 1H), 8.18 (d,J = 2.1 Hz, 1H), 6.86 (ddd,J = 8.3, 2.1, 0.8 Hz, 1H), 6.79 (d,J = 8.3 Hz, 1H), 4.34 (h,J = 6.0 Hz, 1H), 4.20 (s, 2H), 2.30 (d,J = 0.7 Hz, 3H), 1.86 - 1.61 (m, 2H), 1.31 (d,J = 6.1 Hz, 3H), 1.01 (d,J = 7.4 Hz, 3H)；ESIMSm/z 255 ([M+H]+ )。2- 氯-N -(5- 甲基-2-(2,2,2- 三氟乙氧基) 苯 基) 乙醯胺(C58) Prepared from 2-(2-butoxy)-5-methylaniline and isolated as a brown oil (0.600 g, 92%): 1 H NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.18 (d, J = 2.1 Hz, 1H), 6.86 (ddd, J = 8.3, 2.1, 0.8 Hz, 1H), 6.79 (d, J = 8.3 Hz, 1H), 4.34 (h, J = 6.0 Hz, 1H) , 4.20 (s, 2H), 2.30 (d, J = 0.7 Hz, 3H), 1.86 - 1.61 (m, 2H), 1.31 (d, J = 6.1 Hz, 3H), 1.01 (d, J = 7.4 Hz, 3H); ESIMS m/z 255 ([M+H] + ). 2-Chloro - N - (5- methyl-2- (2,2,2-trifluoroethoxy) phenyl) acetyl amine (C58)

從5-甲基-2-(2,2,2-三氟乙氧基)苯胺製備且單離為棕色半固體(0.660g，95%)：1 H NMR (400 MHz, CDCl3 ) δ 8.94 (s, 1H), 8.19 (d,J = 2.1 Hz, 1H), 6.91 (ddd,J = 8.3, 2.1, 0.8 Hz, 1H), 6.78 (d,J = 8.4 Hz, 1H), 4.40 (q,J = 8.0 Hz, 2H), 4.21 (s, 2H),  2.33 (s, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -74.20；ESIMSm/z 281 ([M+H]+ )。 N -(2-( 三 級丁氧基)-5- 甲基苯 基 )-2- 氯乙醯胺(C59) Prepared from 5-methyl-2-(2,2,2-trifluoroethoxy)aniline and isolated as a brown semi-solid (0.660 g, 95%): 1 H NMR (400 MHz, CDCl 3 ) δ 8.94 (s, 1H), 8.19 (d, J = 2.1 Hz, 1H), 6.91 (ddd, J = 8.3, 2.1, 0.8 Hz, 1H), 6.78 (d, J = 8.4 Hz, 1H), 4.40 (q, J = 8.0 Hz, 2H), 4.21 (s, 2H), 2.33 (s, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ -74.20; ESIMS m/z 281 ([M+H] + ). N - (2- (three-butoxy) -5-methyl-phenyl) -2-chloro-acetyl-amine (C59)

從2-(三級丁氧基)-5-甲基苯胺製備且單離為黃色油(2.16g，93%)：1 H NMR (400 MHz, CDCl3 ) δ 9.13 (s, 1H), 8.21 (d,J = 2.1 Hz, 1H), 6.97 (d,J = 8.2 Hz, 1H), 6.87 - 6.76 (m, 1H), 4.20 (s, 2H), 2.32 (s, 3H), 1.42 (s, 9H)；13 C NMR (101 MHz, CDCl3 ) δ 163.19, 142.22, 133.32, 131.21, 124.61, 121.40, 120.05, 80.77, 43.17, 28.86, 21.20；EIMSm/z 256 ([M]+ )。2- 氯-N -(5- 甲基-2-( 三氟甲基) 苯 基) 乙醯胺(C60) Prepared from 2-(tertiary butoxy)-5-methylaniline and isolated as a yellow oil (2.16 g, 93%): 1 H NMR (400 MHz, CDCl 3 ) δ 9.13 (s, 1H), 8.21. (d, J = 2.1 Hz, 1H), 6.97 (d, J = 8.2 Hz, 1H), 6.87 - 6.76 (m, 1H), 4.20 (s, 2H), 2.32 (s, 3H), 1.42 (s, 9H); 13 C NMR (101 MHz, CDCl 3 ) δ 163.19, 142.22, 133.32, 131.21, 124.61, 121.40, 120.05, 80.77, 43.17, 28.86, 21.20; EIMS m/z 256 ([M] + ). 2-Chloro - N - (5- methyl-2- (trifluoromethyl) phenyl) acetyl amine (of C60)

從5-甲基-2-(三氟甲基)苯胺製備且單離為白色固體(2.79g，96%)：mp 109-110 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.69 (s, 1H), 8.02 (s, 1H), 7.52 (d,J = 8.0 Hz, 1H), 7.09 (ddt,J = 7.9, 1.6, 0.8 Hz, 1H), 4.22 (s, 2H), 2.42 (t,J = 0.9 Hz, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -60.29；EIMSm/z 251 ([M]+ )。2- 氯-N -(2- 氯-5- 甲基苯 基) 乙醯胺(C61) Prepared from 5-methyl-2-(trifluoromethyl)aniline and isolated as a white solid (2.79 g, 96%): mp 109-110 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.69 (s , 1H), 8.02 (s, 1H), 7.52 (d, J = 8.0 Hz, 1H), 7.09 (ddt, J = 7.9, 1.6, 0.8 Hz, 1H), 4.22 (s, 2H), 2.42 (t, J = 0.9 Hz, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ -60.29; EIMS m/z 251 ([M] + ). 2-Chloro - N - (2- chloro-5-methylphenyl) acetyl amine (C61)

從2-氯-5- 甲基苯胺製備且單離為紫色固體(4.50g，96%)：mp 112-114 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.87 (s, 1H), 8.26 - 8.12 (m, 1H), 7.27 (d,J = 8.4 Hz, 1H), 6.91 (ddq,J = 8.2, 2.2, 0.7 Hz, 1H), 4.23 (s, 2H), 2.35 (d,J = 0.7 Hz, 3H)；EIMSm/z 218 ([M]+ )。2- 氯-N -(2-(1- 甲氧基乙基)-5- 甲基苯 基) 乙醯胺(C62) Methylaniline and isolated as a purple solid (4.50g, 96%) - from 2-chloro -5: mp 112-114 ℃; 1 H NMR (400 MHz, CDCl 3) δ 8.87 (s, 1H), 8.26 - 8.12 (m, 1H), 7.27 (d, J = 8.4 Hz, 1H), 6.91 (ddq, J = 8.2, 2.2, 0.7 Hz, 1H), 4.23 (s, 2H), 2.35 (d, J = 0.7 Hz, 3H); EIMS m/z 218 ([M] + ). 2-Chloro - N - (2- (1- methoxyethyl) -5-methyl-phenyl) acetyl amine (C62)

從2-(1-甲氧基乙基)-5-甲基苯胺(C87) 製備且單離為黃色油(2.19g，71%)：1 H NMR (300 MHz, CDCl3 ) δ 10.16 (s, 1H), 8.17 (s, 1H), 7.02 (d,J = 7.7 Hz, 1H), 6.99 - 6.85 (m, 1H), 4.45 (q,J = 6.7 Hz, 1H), 4.20 (dd,J = 2.6, 1.1 Hz, 2H), 3.34 (d,J = 1.1 Hz, 3H), 2.37 (d,J = 1.0 Hz, 3H), 1.52 (dd,J = 6.9, 1.0 Hz, 3H)；13 C NMR (126 MHz, CDCl3 ) δ 164.22, 138.56, 135.55, 128.26, 127.41, 125.20, 122.16, 80.90, 77.31, 77.05, 76.80, 56.25, 43.10, 21.37, 20.95。2- 氯-N -(2-( 甲氧基甲基)-5- 甲基苯 基) 乙醯胺(C63) Prepared from 2-(1-methoxyethyl)-5-methylaniline (C87) and isolated as a yellow oil (2.19 g, 71%): 1 H NMR (300 MHz, CDCl 3 ) δ 10.16 (s , 1H), 8.17 (s, 1H), 7.02 (d, J = 7.7 Hz, 1H), 6.99 - 6.85 (m, 1H), 4.45 (q, J = 6.7 Hz, 1H), 4.20 (dd, J = 2.6, 1.1 Hz, 2H), 3.34 (d, J = 1.1 Hz, 3H), 2.37 (d, J = 1.0 Hz, 3H), 1.52 (dd, J = 6.9, 1.0 Hz, 3H); 13 C NMR ( 126 MHz, CDCl 3 ) δ 164.22, 138.56, 135.55, 128.26, 127.41, 125.20, 122.16, 80.90, 77.31, 77.05, 76.80, 56.25, 43.10, 21.37, 20.95. 2-Chloro - N - (2- (methoxymethyl) -5-methyl-phenyl) acetyl amine (C63 of)

從2-(甲氧基甲基)-5-甲基苯胺(C51) 製備且單離為橘色油(1.89g，77%)：1 H NMR (400 MHz, CDCl3 ) δ 9.74 (s, 1H), 8.01 - 7.95 (m, 1H), 7.09 (d,J = 7.6 Hz, 1H), 6.97 - 6.88 (m, 1H), 4.49 (s, 2H), 4.23 (s, 2H), 3.43 (s, 3H), 2.36 (s, 3H)；13 C NMR (101 MHz, CDCl3 ) δ 164.65, 139.40, 136.56, 129.19, 125.42, 124.08, 122.41, 73.55, 58.01, 43.06, 40.47；EIMSm/z 227 ([M]+ )。2- 氯-N -(2-(2,2- 二氟環丙基)-5- 甲基苯 基) 乙醯胺(C64) Prepared from 2-(methoxymethyl)-5-methylaniline (C51) and isolated as orange oil (1.89 g, 77%): 1 H NMR (400 MHz, CDCl 3 ) δ 9.74 (s, 1H), 8.01 - 7.95 (m , 1H), 7.09 (d, J = 7.6 Hz, 1H), 6.97 - 6.88 (m, 1H), 4.49 (s, 2H), 4.23 (s, 2H), 3.43 (s , 3H), 2.36 (s, 3H); 13 C NMR (101 MHz, CDCl 3 ) δ 164.65, 139.40, 136.56, 129.19, 125.42, 124.08, 122.41, 73.55, 58.01, 43.06, 40.47; EIMS m/z 227 ( [M] + ). 2-Chloro - N - (2- (2,2- difluoro-cyclopropyl) -5-methyl-phenyl) acetyl amine (C64)

從2-(2,2-二氟環丙基)-5-甲基苯胺(C90) 製備且單離為棕色固體(0.600g，84%)：mp 103-107 ℃；1 H NMR (400 MHz, CDCl3 ) δ 10.21 (s, 1H), 8.40 - 8.24 (m, 1H), 7.32 (ddd,J = 8.5, 6.7, 2.3 Hz, 1H), 7.15 - 7.05 (m, 2H), 4.19 (d,J = 5.3 Hz, 2H), 3.34 (s, 3H), 1.53 (d,J = 6.7 Hz, 4H)；19 F NMR (376 MHz, CDCl3 ) δ -126.50, -126.91, -139.52, -139.92。2- 氯-N -(5- 甲基-2- 丙基苯 基) 乙醯胺(C65) Prepared from 2-(2,2-difluorocyclopropyl)-5-methylaniline (C90) and isolated as a brown solid (0.600 g, 84%): mp 103-107 ° C; 1 H NMR (400 MHz , CDCl 3 ) δ 10.21 (s, 1H), 8.40 - 8.24 (m, 1H), 7.32 (ddd, J = 8.5, 6.7, 2.3 Hz, 1H), 7.15 - 7.05 (m, 2H), 4.19 (d, J = 5.3 Hz, 2H), 3.34 (s, 3H), 1.53 (d, J = 6.7 Hz, 4H); 19 F NMR (376 MHz, CDCl 3 ) δ -126.50, -126.91, -139.52, -139.92. 2-Chloro - N - (5- methyl-2-propylbenzene-yl) acetyl amine (C65)

從5-甲基-2-丙基苯胺製備且單離為粉紅色固體(1.86g，92%)： mp 108-111 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.28 (s, 1H), 7.74 - 7.69 (m, 1H), 7.09 (d,J = 7.8 Hz, 1H), 6.98 - 6.94 (m, 1H), 4.24 (s, 2H), 2.55 (dd,J = 8.6, 6.8 Hz, 2H), 2.34 (s, 3H), 1.67 - 1.57 (m, 2H), 0.99 (td,J = 7.3, 2.9 Hz, 3H)；13 C NMR (101 MHz, CDCl3 ) δ 132.21, 130.32, 129.67, 126.64, 123.34, 43.24, 33.16, 23.23, 13.94；EIMSm/z 225 ([M]+ )。2- 氯-N -(4- 氟-2- 異丙基-5- 甲基苯 基) 乙醯胺(C66) Prepared from 5-methyl-2-propylaniline and isolated as a pink solid (1.86 g, 92%): mp 108-111 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.28 (s, 1H) , 7.74 - 7.69 (m, 1H), 7.09 (d, J = 7.8 Hz, 1H), 6.98 - 6.94 (m, 1H), 4.24 (s, 2H), 2.55 (dd, J = 8.6, 6.8 Hz, 2H ), 2.34 (s, 3H), 1.67 - 1.57 (m, 2H), 0.99 (td, J = 7.3, 2.9 Hz, 3H); 13 C NMR (101 MHz, CDCl 3 ) δ 132.21, 130.32, 129.67, 126.64 , 123.34, 43.24, 33.16, 23.23, 13.94; EIMS m/z 225 ([M] + ). 2-Chloro - N - (4- fluoro-2-isopropyl-5-methylphenyl) acetyl amine (C66)

從4-氟-2-異丙基-5-甲基苯胺(C49) 製備且單離為橘色固體(1.20g，85%)： mp 126-134 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.13 (s, 1H), 7.50 (d,J = 7.4 Hz, 1H), 6.94 (d,J = 10.9 Hz, 1H), 4.24 (s, 2H), 3.05 - 2.88 (m, 1H), 2.24 (dd,J = 2.0, 0.7 Hz, 3H), 1.24 (d,J = 6.8 Hz, 6H)；19 F NMR (376 MHz, CDCl3 ) δ -118.99；EIMSm/z 243 ([M]+ )。2- 氯-N -(2- 異丙基-5-( 三氟甲基) 苯 基) 乙醯胺(C67) Prepared from 4-fluoro-2-isopropyl-5-methylaniline (C49) and isolated as an orange solid (1.20 g, 85%): mp 126-134 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.13 (s, 1H), 7.50 (d, J = 7.4 Hz, 1H), 6.94 (d, J = 10.9 Hz, 1H), 4.24 (s, 2H), 3.05 - 2.88 (m, 1H), 2.24 (dd, J = 2.0, 0.7 Hz, 3H), 1.24 (d, J = 6.8 Hz, 6H); 19 F NMR (376 MHz, CDCl 3 ) δ -118.99; EIMS m/z 243 ([M] + ) . 2-Chloro - N - (2- isopropyl-5- (trifluoromethyl) phenyl) acetyl amine (C67)

從2-異丙基-5-(三氟甲基)苯胺(C50) 製備且單離為橘色油(0.560g，100%)：1 H NMR (500 MHz, CDCl3 ) δ 8.41 (s, 1H), 8.20 - 8.13 (m, 1H), 7.50 - 7.40 (m, 2H), 4.28 (s, 2H), 3.07 (p,J = 6.9 Hz, 1H), 1.31 (d,J = 6.8 Hz, 6H)；19 F NMR (471 MHz, CDCl3 ) δ -62.51；EIMSm/z 278 ([M]+ )。實施例21 ：3-(2- 氟-5- 甲基苯 基)-2- 亞胺基噻唑烷-4- 酮(C68) 之製備 Prepared from 2-isopropyl-5-(trifluoromethyl)aniline (C50) and isolated as orange oil (0.560 g, 100%): 1 H NMR (500 MHz, CDCl 3 ) δ 8.41 (s, 1H), 8.20 - 8.13 (m, 1H), 7.50 - 7.40 (m, 2H), 4.28 (s, 2H), 3.07 (p, J = 6.9 Hz, 1H), 1.31 (d, J = 6.8 Hz, 6H 19 F NMR (471 MHz, CDCl 3 ) δ -62.51; EIMS m/z 278 ([M] + ). Example 21: 3- (2-fluoro-5-methylphenyl) -2-imino-thiazolidin-4-one (C68) of

將2-氯-N -(2-氟-5-甲基苯基)乙醯胺(C52) (2.00g，9.92 mmol)及丙酮(9.92 mL)添加至反應燒瓶。加入固體硫氰酸鉀(1.93g，19.8 mmol)，以及反應係以65 ℃加熱歷時3小時。使反應冷卻至室溫。添加碳酸銫(0.162g，0.496 mmol)，以及反應係於室溫下攪拌歷時45分鐘。反應混合物係經Celite®予以過濾、以丙酮清洗，並濃縮。藉由急速管柱層析法予以純化，使用0-60%乙酸乙酯/己烷作為沖提液，提供如淡橘色固體之標題化合物(1.790g，80%)：mp 120-122 ℃；1 H NMR (400 MHz, CDCl3 ) δ 7.89 (s, 1H), 7.24 (s, 1H), 7.20 - 7.01 (m, 2H), 4.20 - 3.99 (m, 2H), 2.36 (s, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -125.16；ESIMSm/z 225 ([M+H]+ )。2-Chloro- N- (2-fluoro-5-methylphenyl)acetamide (C52) (2.00 g, 9.92 mmol) and acetone (9.92 mL) were added to the reaction flask. Solid potassium thiocyanate (1.93 g, 19.8 mmol) was added, and the reaction was heated at 65 °C for 3 hours. The reaction was allowed to cool to room temperature. Cesium carbonate (0.162 g, 0.496 mmol) was added and the reaction was stirred at room temperature for 45 min. The reaction mixture was filtered through Celite®, washed with acetone and concentrated. The title compound (1.790 g, 80%): mp 120-122 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 7.89 (s, 1H), 7.24 (s, 1H), 7.20 - 7.01 (m, 2H), 4.20 - 3.99 (m, 2H), 2.36 (s, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ - 125.16; ESI MS m/z 225 ([M+H] + ).

下列化合物係以實施例 21 中概述之流程相似的方式予以製備：2- 亞胺基-3-(2- 甲氧基-5- 甲基苯 基) 噻唑烷-4- 酮(C69) The following compound is to be prepared in a similar manner as the procedure outlined in Example 21: 2-amino-3- (2-methoxy-5-methylbenzene-yl) thiazol-4-one (C69)

從2-氯-N -(2-甲氧基-5-甲基苯基)乙醯胺(C53) 製備(0.814g，36%)：1 H NMR (400 MHz, DMSO-d6 ) δ 9.12 (s, 1H), 7.29 - 7.15 (m, 1H), 7.03 (d,J = 8.4 Hz, 1H), 6.94 (s, 1H), 4.15 (d,J = 2.6 Hz, 2H), 3.69 (s, 3H), 2.25 (s, 3H)；ESIMSm/z 237 ([M+H]+ )。3-(2- 乙氧基-5- 甲基苯 基)-2- 亞胺基噻唑烷-4- 酮(C70) Preparation from 2-chloro- N- (2-methoxy-5-methylphenyl)acetamide (C53) (0.814 g, 36%): 1 H NMR (400 MHz, DMSO- d 6 ) δ 9.12 (s, 1H), 7.29 - 7.15 (m, 1H), 7.03 (d, J = 8.4 Hz, 1H), 6.94 (s, 1H), 4.15 (d, J = 2.6 Hz, 2H), 3.69 (s, 3H), 2.25 (s, 3H); ESIMS m/z 237 ([M+H] + ). 3- (2-ethoxy-5-methylphenyl) -2-imino-thiazolidin-4-one (C70)

從2-氯-N -(2-乙氧基-5-甲基苯基)乙醯胺(C53) 製備且單離為棕色固體(0.545g，59%)：65-70 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.31 (s, 1H), 8.17 - 8.10 (m, 1H), 6.88 (ddd,J = 8.4, 2.1, 0.9 Hz, 1H), 6.78 (d,J = 8.3 Hz, 1H), 4.11 (q,J = 7.0 Hz, 2H), 3.91 (s, 2H), 2.30 (t,J = 0.7 Hz, 3H), 1.46 (t,J = 7.0 Hz, 3H)；13 C NMR (126 MHz, CDCl3 ) δ 162.07, 145.26, 130.58, 126.23, 125.14, 120.48, 110.91, 110.84, 64.48, 38.10, 20.94, 14.87；ESIMSm/z 250 ([M+H]+ )。2- 亞胺基-3-(5- 甲基-2-( 三氟甲氧基) 苯 基) 噻唑烷-4- 酮(C71) Prepared from 2-chloro- N- (2-ethoxy-5-methylphenyl)acetamide (C53) and isolated as a brown solid (0.545 g, 59%): 65-70 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.31 (s, 1H), 8.17 - 8.10 (m, 1H), 6.88 (ddd, J = 8.4, 2.1, 0.9 Hz, 1H), 6.78 (d, J = 8.3 Hz, 1H ), 4.11 (q, J = 7.0 Hz, 2H), 3.91 (s, 2H), 2.30 (t, J = 0.7 Hz, 3H), 1.46 (t, J = 7.0 Hz, 3H); 13 C NMR (126 MHz, CDCl 3 ) δ 162.07, 145.26, 130.58, 126.23, 125.14, 120.48, 110.91, 110.84, 64.48, 38.10, 20.94, 14.87; ESIMS m/z 250 ([M+H] + ). 2-amino-3- (5-methyl-2- (trifluoromethoxy) phenyl) thiazol-4-one (C71)

從2-氯-N -(5-甲基-2-(三氟甲氧基)苯基)乙醯胺(C55) 製備且單離為橘色油(1.35g，93%)：1 H NMR (400 MHz, CDCl3 ) δ 7.89 (s, 1H), 7.31 (s, 2H), 7.17 - 7.09 (m, 1H), 4.15 - 4.05 (m, 2H), 2.40 (d,J = 0.8 Hz, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -57.38；ESIMSm/z 290 ([M+H]+ )。2- 亞胺基-3-(2- 異丙基-5- 甲基苯 基) 噻唑烷-4- 酮(C72) Prepared from 2-chloro- N- (5-methyl-2-(trifluoromethoxy)phenyl)acetamide (C55) and isolated as orange oil (1.35 g, 93%): 1 H NMR (400 MHz, CDCl 3 ) δ 7.89 (s, 1H), 7.31 (s, 2H), 7.17 - 7.09 (m, 1H), 4.15 - 4.05 (m, 2H), 2.40 (d, J = 0.8 Hz, 3H 19 F NMR (376 MHz, CDCl 3 ) δ -57.38; ESIMS m/z 290 ([M+H] + ). 2-amino-3- (2-isopropyl-5-methyl phenyl) thiazol-4-one (C72)

從2-氯-N -(2-異丙氧基-5-甲基苯基)乙醯胺(C56) 製備且單離為黃色固體(0.700g，98%)：mp 58-60 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.39 (s, 1H), 8.23 - 8.04 (m, 1H), 6.95 - 6.84 (m, 1H), 6.80 (d,J = 8.4 Hz, 1H), 4.60 (hept,J = 6.1 Hz, 1H), 3.90 (s, 2H), 2.30 (s, 3H), 1.38 (d,J = 6.1 Hz, 6H)；13 C NMR (126 MHz, CDCl3 ) δ 161.99, 144.11, 130.61, 127.14, 125.13, 120.51, 112.58, 110.78, 71.60, 38.05, 30.95, 22.15, 20.95；ESIMSm/z 264 ([M+H]+ )。3-(2-( 二級丁氧基)-5- 甲基苯 基)-2- 亞胺基噻唑烷-4- 酮(C73) From 2-Chloro - N - prepared as acetamide (C56) (2- isopropoxy-5-methylphenyl) and isolated as a yellow solid (0.700g, 98%): mp 58-60 ℃; 1 H NMR (400 MHz, CDCl 3 ) δ 8.39 (s, 1H), 8.23 - 8.04 (m, 1H), 6.95 - 6.84 (m, 1H), 6.80 (d, J = 8.4 Hz, 1H), 4.60 (hept , J = 6.1 Hz, 1H), 3.90 (s, 2H), 2.30 (s, 3H), 1.38 (d, J = 6.1 Hz, 6H); 13 C NMR (126 MHz, CDCl 3 ) δ 161.99, 144.11, 130.61, 127.14, 125.13, 120.51, 112.58, 110.78, 71.60, 38.05, 30.95, 22.15, 20.95; ESIMS m/z 264 ([M+H] + ). 3- (2- (two-butoxy) -5-methyl-phenyl) -2-imino-thiazolidin-4-one (C73)

從N -(2-(二級丁氧基)-5-甲基苯基)-2-氯乙醯胺(C57) 製備且單離為黃色油(0.528g，75%)：1 H NMR (400 MHz, CDCl3 ) δ 8.42 (s, 1H), 8.19 - 8.11 (m, 1H), 6.88 (ddd,J = 8.4, 2.2, 0.8 Hz, 1H), 6.79 (d,J = 8.3 Hz, 1H), 4.36 (h,J = 6.1 Hz, 1H), 3.90 (s, 2H), 2.30 (d,J = 0.7 Hz, 3H), 1.80 (ddd,J = 13.7, 7.6, 6.2 Hz, 1H), 1.74 - 1.61 (m, 1H), 1.33 (d,J = 6.1 Hz, 3H), 1.00 (t,J = 7.5 Hz, 3H)；13 C NMR (126 MHz, CDCl3 ) δ 161.96, 144.31, 130.52, 127.15, 125.11, 120.47, 112.53, 110.74, 38.02, 29.15, 20.94, 19.34, 9.84；ESIMSm/z 278 ([M+H]+ )。2- 亞胺基-3-(5- 甲基-2-(2,2,2- 三氟乙氧基) 苯 基) 噻唑烷-4- 酮(C74) Prepared from N- (2-(2-butoxy)-5-methylphenyl)-2-chloroacetamide (C57) and isolated as a yellow oil (0.528 g, 75%): 1 H NMR ( 400 MHz, CDCl 3 ) δ 8.42 (s, 1H), 8.19 - 8.11 (m, 1H), 6.88 (ddd, J = 8.4, 2.2, 0.8 Hz, 1H), 6.79 (d, J = 8.3 Hz, 1H) , 4.36 (h, J = 6.1 Hz, 1H), 3.90 (s, 2H), 2.30 (d, J = 0.7 Hz, 3H), 1.80 (ddd, J = 13.7, 7.6, 6.2 Hz, 1H), 1.74 - 1.61 (m, 1H), 1.33 (d, J = 6.1 Hz, 3H), 1.00 (t, J = 7.5 Hz, 3H); 13 C NMR (126 MHz, CDCl 3 ) δ 161.96, 144.31, 130.52, 127.15, 125.11, 120.47, 112.53, 110.74, 38.02, 29.15, 20.94, 19.34, 9.84; ESIMS m/z 278 ([M+H] + ). 2-amino-3- (5-methyl-2- (2,2,2-trifluoroethoxy) phenyl) thiazol-4-one (C74)

從2-氯-N -(5-甲基-2-(2,2,2-三氟乙氧基)苯基)乙醯胺(C58) 製備且單離為灰白色固體(0.510g，71%)：mp 127-129 ℃；1 H NMR (400 MHz, CDCl3 ) δ 8.18 (d,J = 15.6 Hz, 2H), 6.93 (d,J = 8.3 Hz, 1H), 6.80 (d,J = 8.3 Hz, 1H), 4.43 (q,J = 8.0 Hz, 2H), 3.90 (s, 2H), 2.33 (d,J = 0.8 Hz, 3H)；19 F NMR (376 MHz, CDCl3 ) δ -73.95；ESIMSm/z 304 ([M+H]+ )。3-(2-( 三 級丁氧基)-5- 甲基苯 基)-2- 亞胺基噻唑烷-4- 酮(C75) Prepared from 2-chloro- N- (5-methyl-2-(2,2,2-trifluoroethoxy)phenyl)acetamide (C58) and isolated as an off-white solid (0.510 g, 71% ): mp 127-129 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 8.18 (d, J = 15.6 Hz, 2H), 6.93 (d, J = 8.3 Hz, 1H), 6.80 (d, J = 8.3 Hz, 1H), 4.43 (q, J = 8.0 Hz, 2H), 3.90 (s, 2H), 2.33 (d, J = 0.8 Hz, 3H); 19 F NMR (376 MHz, CDCl 3 ) δ -73.95; ESIMS m/z 304 ([M+H] + ). 3- (2- (three-butoxy) -5-methyl-phenyl) -2-imino-thiazolidin-4-one (C75)

從N -(2-(三級丁氧基)-5-甲基苯基)-2-氯乙醯胺(C59) 製備且單離為棕色油(0.158g，7%)：1 H NMR (400 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.17 (d,J = 8.7 Hz, 1H), 7.11 (d,J = 8.4 Hz, 1H), 7.00 (s, 1H), 4.03 (s, 2H), 2.33 (t,J = 0.7 Hz, 3H), 1.34 (s, 9H)；ESIMSm/z 278 ([M+H]+ )。2- 亞胺基-3-(5- 甲基-2-( 三氟甲基) 苯 基) 噻唑烷-4- 酮(C76) Prepared from N- (2-(tertiarybutoxy)-5-methylphenyl)-2-chloroacetamide (C59) and isolated as a brown oil (0.158 g, 7%): 1 H NMR ( 400 MHz, CDCl 3 ) δ 7.80 (s, 1H), 7.17 (d, J = 8.7 Hz, 1H), 7.11 (d, J = 8.4 Hz, 1H), 7.00 (s, 1H), 4.03 (s, 2H) ), 2.33 (t, J = 0.7 Hz, 3H), 1.34 (s, 9H); ESIMS m/z 278 ([M+H] + ). 2-amino-3- (5-methyl-2- (trifluoromethyl) phenyl) thiazol-4-one (C76)

從2-氯-N -(5-甲基-2-(三氟甲基)苯基)乙醯胺(C60) 製備且單離為橘色固體(2.63g，84%)：mp 118-127 ℃；1 H NMR (400 MHz, DMSO-d6 ) δ 9.33 (s, 1H), 7.74 (d,J = 8.0 Hz, 1H), 7.50 (ddd,J = 8.0, 1.8, 0.9 Hz, 1H), 7.29 (t,J = 1.2 Hz, 1H), 4.29 - 4.09 (m, 2H), 2.41 (s, 3H)；19 F NMR (376 MHz, DMSO-d6 ) δ -59.80；ESIMSm/z 275 ([M+H]+ )。3-(2- 氯-5- 甲基苯 基)-2- 亞胺基噻唑烷-4- 酮(C77) Prepared from 2-chloro- N- (5-methyl-2-(trifluoromethyl)phenyl)acetamide (C60) and isolated as an orange solid (2.63 g, 84%): mp 118-127 ℃; 1 H NMR (400 MHz , DMSO- d 6) δ 9.33 (s, 1H), 7.74 (d, J = 8.0 Hz, 1H), 7.50 (ddd, J = 8.0, 1.8, 0.9 Hz, 1H), 7.29 (t, J = 1.2 Hz, 1H), 4.29 - 4.09 (m, 2H), 2.41 (s, 3H); 19 F NMR (376 MHz, DMSO- d 6 ) δ -59.80; ESIMS m/z 275 ( [M+H] + ). 3- (2-chloro-5-methylphenyl) -2-imino-thiazolidin-4-one (C77)

從2-氯-N -(2-氯-5-甲基苯基)乙醯胺(C61) 製備且單離為黃色固體(3.00g，90%)：mp 125-127 ℃；1 H NMR (400 MHz, DMSO-d6 ) δ 9.31 (s, 1H), 7.49 (d,J = 8.2 Hz, 1H), 7.35 - 7.25 (m, 1H), 7.21 (d,J = 2.1 Hz, 1H), 4.30 - 4.13 (m, 2H), 2.32 (s, 3H)；13 C NMR (126 MHz, DMSO-d6 ) δ 170.36, 156.15, 137.25, 131.98, 130.96, 130.61, 128.76, 128.22, 33.13, 19.56；ESIMSm/z 241 ([M+H]+ )。2- 亞胺基-3-(2-(1- 甲氧基乙基)-5- 甲基苯 基) 噻唑烷-4- 酮(C78) Prepared from 2-chloro- N- (2-chloro-5-methylphenyl)acetamide (C61) and isolated as a yellow solid (3.00 g, 90%): mp 125-127 ° C; 1 H NMR ( 400 MHz, DMSO- d 6 ) δ 9.31 (s, 1H), 7.49 (d, J = 8.2 Hz, 1H), 7.35 - 7.25 (m, 1H), 7.21 (d, J = 2.1 Hz, 1H), 4.30 - 4.13 (m, 2H), 2.32 (s, 3H); 13 C NMR (126 MHz, DMSO- d 6) δ 170.36, 156.15, 137.25, 131.98, 130.96, 130.61, 128.76, 128.22, 33.13, 19.56; ESIMS m /z 241 ([M+H] + ). 2-amino-3- (2- (l-methoxyethyl) -5-methyl-phenyl) thiazol-4-one (C78)

從2-氯-N -(2-(1-甲氧基乙基)-5-甲基苯基)乙醯胺(C62) 製備且單離為橘色固體(1.80g，71%)： mp 94-108 ℃；1 H NMR (300 MHz, CDCl3 ) δ 7.51 (d,J = 7.9 Hz, 1H), 7.34 (dd,J = 8.0, 1.9 Hz, 1H), 7.00 6.86 (m, 1H), 4.21 4.05 (m, 2H), 3.12 (d,J = 1.1 Hz, 2H), 2.38 (s, 3H), 1.42 1.31 (m, 3H)；13 C NMR (75 MHz, CDCl3 ) δ 210.86, 170.85, 139.07, 131.65, 129.19, 129.06, 127.13, 77.52, 77.09, 76.67, 74.46, 74.15, 69.51, 56.72, 56.54, 53.81, 31.76, 29.28, 23.35, 20.98。2- 亞胺基-3-(2-( 甲氧基甲基)-5- 甲基苯基) 噻唑烷-4- 酮(C79) Prepared from 2-chloro- N- (2-(1-methoxyethyl)-5-methylphenyl)acetamide (C62) and isolated as an orange solid (1.80 g, 71%): mp 94-108 °C; 1 H NMR (300 MHz, CDCl 3 ) δ 7.51 (d, J = 7.9 Hz, 1H), 7.34 (dd, J = 8.0, 1.9 Hz, 1H), 7.00 6.86 (m, 1H), 4.21 4.05 (m, 2H), 3.12 (d, J = 1.1 Hz, 2H), 2.38 (s, 3H), 1.42 1.31 (m, 3H); 13 C NMR (75 MHz, CDCl 3 ) δ 210.86, 170.85, 139.07, 131.65, 129.19, 129.06, 127.13, 77.52, 77.09, 76.67, 74.46, 74.15, 69.51, 56.72, 56.54, 53.81, 31.76, 29.28, 23.35, 20.98. 2- imino-3-(2-( methoxymethyl)-5 -methylphenyl) thiazolidin-4 -one (C79)

從2-氯-N -(2-(甲氧基甲基)-5-甲基苯基)乙醯胺(C63) 製備且單離為橘色固體(0.550g，25%)：mp 66-71 ℃；1 H NMR (400 MHz, CDCl3 ) δ 9.37 (s, 1H), 8.00 (s, 1H), 7.07 (d,J = 7.6 Hz, 1H), 6.97 - 6.89 (m, 1H), 4.56 (s, 2H), 3.86 (s, 2H), 3.42 (s, 3H), 2.37 (s, 3H)；13 C NMR (101 MHz, CDCl3 ) δ 162.54, 139.50, 136.62, 129.24, 125.51, 123.55, 122.35, 73.76, 57.85, 37.87, 21.45；EIMSm/z 250 ([M]+ )。3-(2-(2,2- 二氟環丙基)-5- 甲基苯 基)-2- 亞胺基噻唑烷-4- 酮 (C80) Prepared from 2-chloro- N- (2-(methoxymethyl)-5-methylphenyl)acetamide (C63) and isolated as an orange solid (0.550 g, 25%): mp 66- 71 °C; 1 H NMR (400 MHz, CDCl 3 ) δ 9.37 (s, 1H), 8.00 (s, 1H), 7.07 (d, J = 7.6 Hz, 1H), 6.97 - 6.89 (m, 1H), 4.56 (s, 2H), 3.86 (s, 2H), 3.42 (s, 3H), 2.37 (s, 3H); 13 C NMR (101 MHz, CDCl 3 ) δ 162.54, 139.50, 136.62, 129.24, 125.51, 123.55, 122.35, 73.76, 57.85, 37.87, 21.45; EIMS m/z 250 ([M] + ). 3- (2- (2,2-difluoro-cyclopropyl) -5-methyl-phenyl) -2-imino-thiazolidin-4-one (C80)

從2-氯-N -(2-(2,2-二氟環丙基)-5-甲基苯基)乙醯胺(C64) 製備且單離為棕色固體 (0.279g，41%)： mp 130-134 ℃；1 H NMR (400 MHz, DMSO-d6 ) δ 10.00 (s, 1H), 7.21 - 7.17 (m, 1H), 7.13 (d,J = 7.9 Hz, 1H), 7.05 (d,J = 7.5 Hz, 1H), 4.13 (s, 2H), 2.88 (td,J = 12.3, 8.2 Hz, 1H), 2.29 (s, 3H), 2.02 - 1.87 (m, 1H), 1.75 (dtd,J = 12.1, 8.0, 3.6 Hz, 1H)；19 F NMR (376 MHz, DMSO-d6 ) δ -124.66, -125.06, -139.62, -140.02；EIMSm/z 284 ([M+H]+ )。2- 亞胺基-3-(5- 甲基-2- 丙基苯 基) 噻唑烷-4- 酮(C81) Prepared from 2-chloro- N- (2-(2,2-difluorocyclopropyl)-5-methylphenyl)acetamide (C64) mp. Mp 130-134 °C; 1 H NMR (400 MHz, DMSO- d 6 ) δ 10.00 (s, 1H), 7.21 - 7.17 (m, 1H), 7.13 (d, J = 7.9 Hz, 1H), 7.05 (d , J = 7.5 Hz, 1H), 4.13 (s, 2H), 2.88 (td, J = 12.3, 8.2 Hz, 1H), 2.29 (s, 3H), 2.02 - 1.87 (m, 1H), 1.75 (dtd, J = 12.1, 8.0, 3.6 Hz, 1H); 19 F NMR (376 MHz, DMSO- d 6 ) δ -124.66, -125.06, -139.62, -140.02; EIMS m/z 284 ([M+H] + ) . 2-amino-3- (5-methyl-2-propylbenzene-yl) thiazol-4-one (C81)

從2-氯-N -(5-甲基-2-丙基苯基)乙醯胺(C65) 製備且單離為白色固體(1.76g，84%)：mp 120-123 ℃；1 H NMR (400 MHz, DMSO-d6 ) δ 9.67 (s, 1H), 7.17 (d,J = 1.7 Hz, 1H), 7.11 (d,J = 7.7 Hz, 1H), 7.00 - 6.93 (m, 1H), 4.11 (s, 2H), 2.52 - 2.48 (m, 2H), 2.25 (s, 3H), 1.50 (h,J = 7.4 Hz, 2H), 0.88 (t,J = 7.3 Hz, 3H)；13 C NMR (126 MHz, DMSO-d6 ) δ 164.20, 134.56, 134.13, 132.75, 128.76, 126.11, 125.70, 112.19, 36.01, 31.68, 22.32, 19.91, 13.23；EIMSm/z 248 ([M]+ )。3-(4- 氟-2- 異丙基-5- 甲基苯 基)-2- 亞胺基噻唑烷-4- 酮(C82) Prepared from 2-chloro- N- (5-methyl-2-propylphenyl)acetamide (C65) and isolated as a white solid (1.76 g, 84%): mp 120-123 ° C; 1 H NMR (400 MHz, DMSO- d 6 ) δ 9.67 (s, 1H), 7.17 (d, J = 1.7 Hz, 1H), 7.11 (d, J = 7.7 Hz, 1H), 7.00 - 6.93 (m, 1H), 4.11 (s, 2H), 2.52 - 2.48 (m, 2H), 2.25 (s, 3H), 1.50 (h, J = 7.4 Hz, 2H), 0.88 (t, J = 7.3 Hz, 3H); 13 C NMR (126 MHz, DMSO- d 6 ) δ 164.20, 134.56, 134.13, 132.75, 128.76, 126.11, 125.70, 112.19, 36.01, 31.68, 22.32, 19.91, 13.23; EIMS m/z 248 ([M] + ). 3- (4-fluoro-2-isopropyl-5-methyl-phenyl) -2-imino-thiazolidin-4-one (C82)

從2-氯-N -(4-氟-2-異丙基-5-甲基苯基)乙醯胺(C66) 製備且單離為棕色油(1.11g，80%)：1 H NMR (400 MHz, CDCl3 ) δ 7.86 (s, 1H), 7.07 (d,J = 10.7 Hz, 1H), 6.93 (d,J = 7.3 Hz, 1H), 4.12 - 4.00 (m, 2H), 2.72 - 2.59 (m, 1H), 2.25 (s, 3H), 1.17 (d,J = 7.0 Hz, 6H)；19 F NMR (376 MHz, CDCl3 ) δ -114.93；ESIMSm/z 267 ([M+H]+ )。2- 亞胺基-3-(2- 異丙基-5-( 三氟甲基) 苯 基) 噻唑烷-4- 酮(C83) Prepared from 2-chloro- N- (4-fluoro-2-isopropyl-5-methylphenyl)acetamide (C66) and isolated as a brown oil (1.11 g, 80%): 1 H NMR ( 400 MHz, CDCl 3 ) δ 7.86 (s, 1H), 7.07 (d, J = 10.7 Hz, 1H), 6.93 (d, J = 7.3 Hz, 1H), 4.12 - 4.00 (m, 2H), 2.72 - 2.59 (m, 1H), 2.25 (s, 3H), 1.17 (d, J = 7.0 Hz, 6H); 19 F NMR (376 MHz, CDCl 3 ) δ -114.93; ESIMS m/z 267 ([M+H] + ). 2-amino-3- (2-isopropyl-5- (trifluoromethyl) phenyl) thiazol-4-one (C83)

從2-氯-N -(2-異丙基-5-(三氟甲基)苯基)乙醯胺(C67) 製備且單離為黃色油：1 H NMR (300 MHz, CDCl3 ) δ 7.90 (s, 1H), 7.70 (d,J = 8.6 Hz, 1H), 7.58 (d,J = 8.3 Hz, 1H), 7.39 (d,J = 1.9 Hz, 1H), 4.14 (s, 2H), 2.81 (p,J = 6.8 Hz, 1H), 1.22 (d,J = 6.8 Hz, 6H)；13 C NMR (126 MHz, CDCl3 ) δ 171.05, 160.01, 151.10, 132.51, 127.72, 127.00, 126.97, 126.16, 126.13, 34.46, 28.83, 23.63, 23.28；19 F NMR (471 MHz, CDCl3 ) δ -62.40；EIMSm/z 301 ([M]+ )。實施例22 ：1-(4- 甲基-2- 硝基苯基) 乙-1- 酮(C84) 之製備 Prepared from 2-chloro- N- (2-isopropyl-5-(trifluoromethyl)phenyl)acetamide (C67) and isolated as a yellow oil: 1 H NMR (300 MHz, CDCl 3 ) δ 7.90 (s, 1H), 7.70 (d, J = 8.6 Hz, 1H), 7.58 (d, J = 8.3 Hz, 1H), 7.39 (d, J = 1.9 Hz, 1H), 4.14 (s, 2H), 2.81 (p, J = 6.8 Hz, 1H), 1.22 (d, J = 6.8 Hz, 6H); 13 C NMR (126 MHz, CDCl 3 ) δ 171.05, 160.01, 151.10, 132.51, 127.72, 127.00, 126.97, 126.16 , 126.13, 34.46, 28.83, 23.63, 23.28; 19 F NMR (471 MHz, CDCl 3 ) δ -62.40; EIMS m/z 301 ([M] + ). Example 22: Preparation of 1-1-one (C84) of (4-methyl-2-nitrophenyl)

將4-甲基-2-硝基-1-(丙-1-烯-2-基)苯(11.4 g，64.3 mmol)、二氯甲烷(292 mL)及甲醇(29.2 mL)添加至反應燒瓶。使反應混合物冷卻至-78℃。使臭氧於反應混合物內起泡，以及反應混合物係於-78℃下攪拌歷時3小時。用氮沖洗反應混合物。加入二甲硫(14.0 mL，189 mmol)，以及允許反應混合物攪拌且加溫至室溫過夜。使反應濃縮。藉由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷作為沖提液，提供如油之標題化合物(8.90g，70%)：1 H NMR (300 MHz, CDCl3 ) δ 7.85 (dd,J = 1.7, 0.8Hz, 1H), 7.50 (ddd,J = 7.8, 1.7, 0.8 Hz, 1H), 7.35 (dd,J = 7.7, 0.9 Hz, 1H), 2.53 (s, 3H), 2.48 (s,3H)。實施例23 ：1-(4- 甲基-2- 硝基苯基) 乙-1- 醇(C85) 之製備 Add 4-methyl-2-nitro-1-(prop-1-en-2-yl)benzene (11.4 g, 64.3 mmol), dichloromethane (292 mL), and methanol (29.2 mL) to the reaction flask . The reaction mixture was cooled to -78 °C. Ozone was bubbled into the reaction mixture and the reaction mixture was stirred at -78 °C for 3 hours. The reaction mixture was flushed with nitrogen. Dimethyl sulfide (14.0 mL, 189 mmol) was added and the reaction mixture was stirred and warmed to room temperature overnight. The reaction was concentrated. It is purified by flash column chromatography, which is based using ethyl acetate / hexanes as eluent, to provide an oil as the title compound (8.90g, 70%): 1 H NMR (300 MHz, CDCl 3) δ 7.85 (dd, J = 1.7, 0.8 Hz, 1H), 7.50 (ddd, J = 7.8, 1.7, 0.8 Hz, 1H), 7.35 (dd, J = 7.7, 0.9 Hz, 1H), 2.53 (s, 3H) , 2.48 (s, 3H). Example 23: Preparation of 1- (4-methyl-2-nitrophenyl) ethan-l-ol (C85) of

於氮氣氛圍下，將1-(4-甲基-2-硝基苯基)乙-1-酮(C84) (8.91g，49.7 mmol)及甲醇(249 mL)添加至反應燒瓶。使反應混合物冷卻至0℃。加入硼氫化鈉(2.26g，59.7 mmol)，以及使反應混合物於0℃下攪拌歷時1小時。允許反應混合物加溫至室溫過夜。反應混合物係用鹽酸(2N)來酸化，以及用二氯甲烷稀釋。將層予以分離，以及用二氯甲烷來萃取水相。組合的有機層係於硫酸鈉上乾燥、過濾及濃縮。藉由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷作為沖提液，提供如綠色油之標題化合物(7.10g，75%)：1 H NMR (400 MHz, CDCl3 ) δ 7.73 - 7.66 (m, 2H), 7.45 (dd,J = 8.0, 2.1 Hz, 1H), 5.45 - 5.26 (m, 1H), 2.42 (s, 3H), 1.54 (s, 3H)。實施例24 ：1-(1- 甲氧基乙基)-4- 甲基-2- 硝苯(C86) 之製備 1-(4-Methyl-2-nitrophenyl)ethan-1-one (C84) (8.91 g, 49.7 mmol) and methanol (249 mL) were added to a reaction flask under a nitrogen atmosphere. The reaction mixture was cooled to 0 °C. Sodium borohydride (2.26 g, 59.7 mmol) was added, and the reaction mixture was stirred at 0 ° C for one hour. The reaction mixture was allowed to warm to room temperature overnight. The reaction mixture was acidified with hydrochloric acid (2N) and diluted with dichloromethane. The layers were separated and the aqueous phase was extracted with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered and concentrated. It is purified by flash column chromatography, which is based using ethyl acetate / hexanes as eluent, to provide the green oil as the title compound (7.10g, 75%): 1 H NMR (400 MHz, CDCl 3) δ 7.73 - 7.66 (m, 2H), 7.45 (dd, J = 8.0, 2.1 Hz, 1H), 5.45 - 5.26 (m, 1H), 2.42 (s, 3H), 1.54 (s, 3H). Preparation of 1- (1-methoxyethyl) -4-methyl-2-nitro benzene (C86) of: Example 24

將1-(4-甲基-2-硝基苯基)乙-1-醇(C85) (6.14g，33.9 mmol)及四氫呋喃(169 mL)添加至乾燥的圓底燒瓶。使反應混合物冷卻至0℃。於氮氣氛圍下，添加氫化鈉(60%油浸，2.03g，50.8 mmol)。反應混合物係於0℃下攪拌歷時30分鐘，繼而加入碘甲烷(3.18 mL，50.8 mmol)。允許反應混合物加溫至室溫且攪拌過夜。反應係用飽和的含水氯化銨予以稀釋，以及添加水。將層予以分離，以及以二氯甲烷(2x)萃取水相。組合的有機層係於硫酸鈉上乾燥、過濾及濃縮。藉由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷作為沖提液，提供如黃色油之標題化合物(7.10g，98%)：1 H NMR (400 MHz, CHCl3) δ 7.78 - 7.68 (m, 1H), 7.61 (d,J = 8.0 Hz, 1H), 7.45 (ddd,J = 8.1, 1.8, 0.9 Hz, 1H), 4.84 (q,J = 6.3 Hz, 1H), 3.19 (d,J = 0.8 Hz, 3H), 2.43 (s, 3H), 1.50 (dd,J = 6.3, 0.8 Hz, 3H)；13 C NMR (126 MHz, CDCl3 ) δ 148.60, 138.44, 136.60, 134.47, 127.44, 124.41, 77.49, 77.23, 76.98, 74.87, 56.82, 23.44, 20.75。實施例25 ：2-(1- 甲氧基乙基)-5- 甲基苯胺(C87) 之製備 1-(4-Methyl-2-nitrophenyl)ethan-1-ol (C85) (6.14 g, 33.9 mmol) and tetrahydrofuran (169 mL) were added to a dry round bottom flask. The reaction mixture was cooled to 0 °C. Sodium hydride (60% oil immersion, 2.03 g, 50.8 mmol) was added under a nitrogen atmosphere. The reaction mixture was stirred at 0 ° C for 30 min then iodomethane (3.18 mL, 50.8 mmol). The reaction mixture was allowed to warm to rt and stirred overnight. The reaction was diluted with saturated aqueous ammonium chloride and water was added. The layers were separated and the aqueous phase was extracted with dichloromethane (2×). The combined organic layers were dried over sodium sulfate, filtered and concentrated. It is purified by flash column chromatography, which is based using ethyl acetate / hexanes as eluent to provide the title compound as a yellow oil (7.10g, 98%) as: 1 H NMR (400 MHz, CHCl3) δ 7.78 - 7.68 (m, 1H), 7.61 (d, J = 8.0 Hz, 1H), 7.45 (ddd, J = 8.1, 1.8, 0.9 Hz, 1H), 4.84 (q, J = 6.3 Hz, 1H), 3.19 (d, J = 0.8 Hz, 3H), 2.43 (s, 3H), 1.50 (dd, J = 6.3, 0.8 Hz, 3H); 13 C NMR (126 MHz, CDCl 3 ) δ 148.60, 138.44, 136.60, 134.47 , 127.44, 124.41, 77.49, 77.23, 76.98, 74.87, 56.82, 23.44, 20.75. (1-methoxyethyl) Preparation of 2-5-methylaniline (C87) of: Example 25

將1-(1-甲氧基乙基)-4-甲基-2-硝苯(C86) (7.00g，35.9 mmol)、氯化鎳(II) (4.65g，35.9 mmol)及甲醇(179 mL)添加至反應燒瓶。於氮氣氛圍下，每2-3分鐘以每份200-500 mg的方式將硼氫化鈉(2.94g，78.0 mmol)添加至反應混合物。反應係用丙酮(6 mL)來驟冷，並且濃縮至大概80 mL。粗混合物係用二氯甲烷來稀釋，以及用水清洗。將層予以分離，以及有機物係予以濃縮。藉由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷作為沖提液，提供如橘色油之標題化合物 (2.99g，45%)：1 H NMR (300 MHz, CHCl3 ) δ 6.87 (d,J = 7.6 Hz, 1H), 6.51 (ddd,J = 7.5, 1.7, 0.8 Hz, 1H), 6.47 (d,J = 1.6 Hz, 1H), 4.36 (q,J = 6.7 Hz, 1H), 4.22 (s, 2H), 3.26 (s, 3H), 2.24 (d,J = 0.8 Hz, 3H), 1.56 - 1.46 (m, 3H)；13 C NMR (126 MHz, CDCl3 ) δ 144.87, 128.61, 122.59, 118.56, 116.95, 80.41, 77.31, 77.06, 76.81, 55.93, 21.09, 20.01。實施例26 ：2- 溴-4- 甲基-1- 乙烯基苯(C88) 之製備 1-(1-Methoxyethyl)-4-methyl-2-nitrobenzene (C86) (7.00 g, 35.9 mmol), nickel (II) chloride (4.65 g, 35.9 mmol) and methanol (179) mL) was added to the reaction flask. Sodium borohydride (2.94 g, 78.0 mmol) was added to the reaction mixture in a portion of 200-500 mg per 2-3 minutes under a nitrogen atmosphere. The reaction was quenched with acetone (6 mL) and concentrated to approximately 80 mL. The crude mixture was diluted with dichloromethane and washed with water. The layers are separated and the organics are concentrated. It is purified by flash column chromatography, which is based using ethyl acetate / hexanes as eluent, to provide an orange oil of the title compound as (2.99g, 45%): 1 H NMR (300 MHz, CHCl 3 ) δ 6.87 (d, J = 7.6 Hz, 1H), 6.51 (ddd, J = 7.5, 1.7, 0.8 Hz, 1H), 6.47 (d, J = 1.6 Hz, 1H), 4.36 (q, J = 6.7 Hz) , 1H), 4.22 (s, 2H), 3.26 (s, 3H), 2.24 (d, J = 0.8 Hz, 3H), 1.56 - 1.46 (m, 3H); 13 C NMR (126 MHz, CDCl 3 ) δ 144.87, 128.61, 122.59, 118.56, 116.95, 80.41, 77.31, 77.06, 76.81, 55.93, 21.09, 20.01. Preparation of 2-bromo-4-methyl-1-vinylbenzene (C88) of: Example 26

在0℃於氮氣下，將正丁基鋰(23.0 mL，55.0 mmol)添加至乾燥的圓底燒瓶中配於無水四氫呋喃(250 mL)之甲基三苯基溴化鏻(20.6g，58.0 mmol)溶液。反應混合物係於0℃下攪拌歷時1小時，然後添加2-溴-4-甲苯甲醛(10.0g，50.0 mmol)。反應混合物係於室溫加溫歷時18小時。反應係用鹽酸(2 N)來驟冷。將有機層分離、於硫酸鈉上乾燥、過濾及濃縮。使固體溶解於二氯甲烷內且用二乙基醚予以再結晶。將濾液濃縮，然後經由急速管柱層析法予以純化二次，其係使用0-20%乙酸乙酯/己烷作為沖提液，以提供如澄清油的標題化合物： (11.5g，99%)：1 H NMR (300 MHz, CDCl3 ) δ 7.44 (d,J = 7.9 Hz, 1H), 7.38 (dd,J = 1.9, 1.0 Hz, 1H), 7.14 - 6.95 (m, 2H), 5.65 (dd,J = 17.4, 1.1 Hz, 1H), 5.30 (dd,J = 11.0, 1.1 Hz, 1H), 2.31 (s, 3H)；13 C NMR (126 MHz, CDCl3 ) δ 139.38, 135.64, 135.62, 135.61, 134.57, 133.28, 128.44, 126.45, 123.49, 115.75, 115.72, 115.69, 115.68, 115.65, 115.64；EIMSm/z 198 ([M]+ )。實施例27 ：2- 溴-1-(2,2- 二氟環丙基)-4- 甲苯(C89) 之製備 n-Butyllithium (23.0 mL, 55.0 mmol) was added to a dry round bottom flask with EtOAc (20.6 g, 58.0 mmol) in anhydrous tetrahydrofuran (250 mL). ) solution. The reaction mixture was stirred at 0 ° C for 1 hour then 2-bromo-4-tolualdehyde (10.0 g, 50.0 mmol). The reaction mixture was warmed at room temperature for 18 hours. The reaction was quenched with hydrochloric acid (2N). The organic layer was separated, dried over sodium sulfate, filtered and concentrated. The solid was dissolved in dichloromethane and recrystallized from diethyl ether. The filtrate was concentrated and purified twice by flash column chromatography using EtOAc EtOAc EtOAc EtOAc EtOAc ): 1 H NMR (300 MHz, CDCl 3 ) δ 7.44 (d, J = 7.9 Hz, 1H), 7.38 (dd, J = 1.9, 1.0 Hz, 1H), 7.14 - 6.95 (m, 2H), 5.65 ( Dd, J = 17.4, 1.1 Hz, 1H), 5.30 (dd, J = 11.0, 1.1 Hz, 1H), 2.31 (s, 3H); 13 C NMR (126 MHz, CDCl 3 ) δ 139.38, 135.64, 135.62, 135.61, 134.57, 133.28, 128.44, 126.45, 123.49, 115.75, 115.72, 115.69, 115.68, 115.65, 115.64; EIMS m/z 198 ([M] + ). Example 27: Preparation of 2-bromo-1- (2,2-difluoro-cyclopropyl) -4- toluene (the C89) of

將2-溴-4-甲基-1-乙烯基苯(C88) (2.00g，10.1 mmol)、碘化鈉(0.304g，2.03 mmol)，及四氫呋喃(13.5 mL)添加至反應小瓶。加入三甲基(三氟甲基)矽烷(6.00 mL，41.0 mmol)，以及反應混合物係於65℃下攪拌歷時3小時。進行相同體積的三批次。組合反應混合物且裝載至矽膠卡匣上。經由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷作為沖提液，以提供如非晶形固體之標題化合物(7.21g，86%)：mp 37–41 ℃；1 H NMR (400 MHz, CDCl3 ) δ 7.43 (s, 1H), 7.08 (s, 2H), 2.82 (td,J = 12.2, 8.3 Hz, 1H), 2.32 (s, 3H), 1.85 (tdd,J = 11.8, 7.9, 5.0 Hz, 1H), 1.57 (dtd,J = 12.9, 8.1, 3.6 Hz, 1H)；19 F NMR (471 MHz, CDCl3 ) δ -126.68, -140.75。實施例28 ：2-(2,2- 二氟環丙基)-5- 甲基苯胺(C90) 之製備 2-Bromo-4-methyl-1-vinylbenzene (C88) (2.00 g, 10.1 mmol), sodium iodide (0.304 g, 2.03 mmol), and tetrahydrofuran (13.5 mL) were added to the reaction vial. Trimethyl(trifluoromethyl)decane (6.00 mL, 41.0 mmol) was added, and the reaction mixture was stirred at 65 ° C for 3 hours. Carry out three batches of the same volume. The reaction mixture was combined and loaded onto a silicone cartridge. Purification by flash column chromatography using ethyl acetate / hexanes eluted to afford titled compound (7.21 g, 86%): mp 37 - 41 ° C; 1 H NMR (400 MHz, CDCl 3 ) δ 7.43 (s, 1H), 7.08 (s, 2H), 2.82 (td, J = 12.2, 8.3 Hz, 1H), 2.32 (s, 3H), 1.85 (tdd, J = 11.8 , 7.9, 5.0 Hz, 1H), 1.57 (dtd, J = 12.9, 8.1, 3.6 Hz, 1H); 19 F NMR (471 MHz, CDCl 3 ) δ -126.68, -140.75. Example 28: 2- (2,2-difluoro-cyclopropyl) -5-methyl aniline (C90) Preparation of

將2-溴-1-(2,2-二氟環丙基)-4-甲苯(C89) (0.627g，2.54 mmol)、醋酸鈀(II)(0.0570g，0.254 mmol)、2,2′-雙(二苯基膦)-1,1′-聯二萘(0.316g，0.508 mmol)、碳酸銫(2.07g，6.34 mmol)、二苯甲酮亞胺(0.920g，5.08 mmol)及甲苯(6.34 mL)，添加至微波反應小瓶。將小瓶加蓋，以及於具有外部IR-感測器監測小瓶側的溫度之Biotage Initiator®微波反應器中，以100 ℃加熱歷時3小時。使粗反應混合物濃縮。殘餘物係溶解於甲醇中，以及添加氫氯酸羥胺(0.138g，1.98 mmol)及醋酸鈉(0.219g，2.66 mmol)。允許反應混合物於室溫下攪拌過夜。反應混合物再次添加氫氯酸羥胺(0.138g，1.98 mmol)及醋酸鈉(0.219g，2.66 mmol)。於室溫下攪拌之後，反應混合物係用二氯甲烷予以稀釋、過濾以及濃縮。藉由急速管柱層析法予以純化，其係使用乙酸乙酯/己烷作為沖提液，提供如棕色固體之標題化合物(0.466g，98%)：1 H NMR (400 MHz, CHCl3) δ 6.97 (d,J = 7.7 Hz, 1H), 6.61 - 6.52 (m, 2H), 3.74 (s, 2H), 2.51 (ddd,J = 13.3, 11.5, 8.0 Hz, 1H), 2.26 (d,J = 0.8 Hz, 3H), 1.90 - 1.75 (m, 1H), 1.55 (dtd,J = 12.8, 7.7, 3.6 Hz, 1H)；19 F NMR (376 MHz, CDCl3 ) δ -126.54, -140.87。實施例29 ：1-( 甲氧基甲基)-4- 甲基-2- 硝苯(C91) 之製備 2-Bromo-1-(2,2-difluorocyclopropyl)-4-toluene (C89) (0.627 g, 2.54 mmol), palladium (II) acetate (0.0570 g, 0.254 mmol), 2, 2' - bis(diphenylphosphino)-1,1'-binaphthalene (0.316 g, 0.508 mmol), cesium carbonate (2.07 g, 6.34 mmol), benzophenone imine (0.920 g, 5.08 mmol) and toluene (6.34 mL), added to the microwave reaction vial. The vial was capped and heated at 100 °C for 3 hours in a Biotage Initiator® microwave reactor with an external IR-sensor to monitor the temperature on the vial side. The crude reaction mixture was concentrated. The residue was dissolved in methanol, and hydroxylamine hydrochloride (0.138 g, 1.98 mmol) and sodium acetate (0.219 g, 2.66 mmol). The reaction mixture was allowed to stir at room temperature overnight. Hydroxylamine hydrochloride (0.138 g, 1.98 mmol) and sodium acetate (0.219 g, 2.66 mmol) were again added to the reaction mixture. After stirring at room temperature, the reaction mixture was diluted with dichloromethane, filtered and concentrated. It is purified by flash column chromatography, which is based using ethyl acetate / hexanes as eluent, to provide a brown solid as the title compound (0.466g, 98%): 1 H NMR (400 MHz, CHCl3) δ 6.97 (d, J = 7.7 Hz, 1H), 6.61 - 6.52 (m, 2H), 3.74 (s, 2H), 2.51 (ddd, J = 13.3, 11.5, 8.0 Hz, 1H), 2.26 (d, J = 0.8 Hz, 3H), 1.90 - 1.75 (m, 1H), 1.55 (dtd, J = 12.8, 7.7, 3.6 Hz, 1H); 19 F NMR (376 MHz, CDCl 3 ) δ -126.54, -140.87. (Methoxymethyl) Preparation of 1-methyl-2-nitro benzene (C91) of: Example 29

在0℃下以小份方式，將氫化鈉(60%油浸，0.217g，5.42 mmol)添加至配於四氫呋喃(20 mL)之(4-甲基-2-硝基苯基)甲醇(0.823g，4.92 mmol)。立即觀察到氣體散展。反應混合物攪拌歷時30分鐘，然後添加碘甲烷(0.460 mL，7.39 mmol)。使反應混合物緩慢地加溫至室溫過夜。反應係以甲醇來驟冷，以及添加水及二氯甲烷。有機層係通經相分離器予以過濾並濃縮，以提供如橘色蠟之標題化合物(1.10g，100%)：1 H NMR (400 MHz, CDCl3 ) δ 7.88 (t,J = 1.2 Hz, 1H), 7.63 (d,J = 7.9 Hz, 1H), 7.49 - 7.41 (m, 1H), 4.80 (s, 2H), 3.48 (s, 3H), 2.43 (s, 3H)；13 C NMR (126 MHz, CDCl3 ) δ 156.37, 138.33, 134.42, 132.03, 128.47, 124.97, 71.07, 58.87, 20.80；EIMSm/z 180 ([M]+ )。Add sodium hydride (60% oil immersion, 0.217 g, 5.42 mmol) to (4-methyl-2-nitrophenyl)methanol (0.823) in tetrahydrofuran (20 mL). g, 4.92 mmol). Gas dispersion was observed immediately. The reaction mixture was stirred for 30 minutes then iodomethane (0.460 mL, 7.39 mmol). The reaction mixture was slowly warmed to room temperature overnight. The reaction was quenched with methanol and water and dichloromethane were added. The organic layer was pass through a phase separator based to be filtered, and concentrated to provide an orange wax such as title compound (1.10g, 100%): 1 H NMR (400 MHz, CDCl 3) δ 7.88 (t, J = 1.2 Hz, 1H), 7.63 (d, J = 7.9 Hz, 1H), 7.49 - 7.41 (m, 1H), 4.80 (s, 2H), 3.48 (s, 3H), 2.43 (s, 3H); 13 C NMR (126 MHz, CDCl 3 ) δ 156.37, 138.33, 134.42, 132.03, 128.47, 124.97, 71.07, 58.87, 20.80; EIMS m/z 180 ([M] + ).

瞭解到一些試劑及反應條件與某些式1之分子或某些式1之分子製備中使用的某些分子內存在的某些官能性，可能是不相容的。在此等情況中，可能必需使用文獻中廣泛報導及熟習此項技術者所熟知的標準保護及去保護協定。此外，在一些情況中，可能必需執行本文中未述及之進一步例行的合成步驟，來完成所欲分子的合成。熟習此項技術者也會瞭解到，可以透過以不同於所述的順序來執行一些合成途徑的步驟，來完成所欲分子的合成。熟習此項技術者也會瞭解到，於所欲分子上執行標準的官能基相互轉變或是取代反應以導入或修飾取代基是可能的。生物 分析法 It is understood that some reagents and reaction conditions may be incompatible with certain functionalities of certain molecules of Formula 1 or certain molecules used in the preparation of certain molecules of Formula 1. In such cases, it may be necessary to use standard protection and deprotection agreements that are widely reported in the literature and are familiar to those skilled in the art. Moreover, in some cases, it may be necessary to perform further synthetic steps not described herein to accomplish the synthesis of the desired molecule. Those skilled in the art will also appreciate that the synthesis of the desired molecule can be accomplished by performing steps of some synthetic routes in a different order than described. Those skilled in the art will also appreciate that it is possible to perform standard conversion or substitution reactions on a desired molecule to introduce or modify a substituent. Bioanalytical method

本文內含括以下對於甜菜夜蛾(Beet Armyworm) (甜菜夜蛾(Spodoptera exigua )、甘藍銀紋夜蛾(Cabbage Looper) (粉紋夜蛾(Trichoplusia ni )，以及對黃熱病蚊(埃及斑蚊(Aedes aegypti )的生物分析，因為其等造成損失。再者，甜菜夜蛾及甘藍銀紋夜蛾為範大廣泛的嚼食性害蟲之兩種良好的指標性物種。此外，碧桃蚜蟲(Green Peach Aphid)為範大廣泛的取食汁液害蟲之良好的指標性物種。和黃熱病蚊一起共四種指標性物種的結果顯示出，式1的分子於控制節肢動物門、軟體動物門，及圓形動物門的害蟲方面之廣泛用途(Drewes等人)。實施例A ：對甜菜夜蛾(Beet Armyworm) ( 甜菜夜蛾 (Spodoptera exigua ) ，LAPHEG) (“BAW”) 與 甘藍銀紋夜蛾(Cabbage Looper) ( 粉紋夜蛾(Trichoplusia ni) ，TRIPNI) (“CL”) 之生物 分析 This article includes the following for Beet Armyworm (Spoonoptera exigua , Cabbage Looper ( Trichoplusia ni ), and yellow fever mosquito (Aedes aegypti) ( Aedes aegypti ) bioanalysis, because of its loss, etc. In addition, beet armyworm and cabbage beetle are two good indicator species of broad-spectrum chewing pests. In addition, Green Peach Aphid) is a good indicator species for a wide range of feeding insect pests. The results of four indicator species together with yellow fever mosquitoes show that the molecules of formula 1 control arthropods, mollusks, and circles. . phylum shaped versatility of pests (Drewes et al.) Example a: Spodoptera exigua (beet armyworm) (beet armyworm (Spodoptera exigua), LAPHEG) ( "BAW") and cabbage looper ( Cabbage Looper) (cabbage looper (Trichoplusia ni), TRIPNI) ( "CL") of bioanalytical

甜菜夜蛾對於紫花苜蓿、蘆筍、甜菜(beets)、柑橘、玉米、棉花、洋蔥、豌豆、胡椒、馬鈴薯、大豆、甜菜(sugar beets)、向日葵、菸草及番茄以及其他作物而言，為經濟上嚴重關切的害蟲。其原產於東南亞但是現在於非洲、澳洲、日本、北美及南歐可找到。幼蟲可以大規模取食，造成破壞性極大的作物損失。已知其對數種某些殺蟲劑有抗藥性。Beet armyworm is economically economical for alfalfa, asparagus, beets, citrus, corn, cotton, onions, peas, peppers, potatoes, soybeans, sugar beets, sunflowers, tobacco and tomatoes, and other crops. Pests of serious concern. It is native to Southeast Asia but is now available in Africa, Australia, Japan, North America and Southern Europe. Larvae can be eaten on a large scale, causing devastating crop losses. It is known to be resistant to several insecticides.

甘藍銀紋夜蛾為全世界都可發現的嚴重害蟲。它會攻擊紫花苜蓿、豆類、甜菜(beets)、青花菜、甘藍、高麗菜、哈密瓜、花椰菜、芹菜、羽衣甘藍(collards)、棉花、黃瓜、茄子、甘藍(kale)、萵苣、甜瓜、芥菜、洋芹、豌豆、胡椒、馬鈴薯、大豆、菠菜、南瓜、番茄、蕪青(turnip)及西瓜，以及其他作物。此物種對於植物非常具破壞性，由於它貪婪的胃口。幼蟲每日會吃掉它們體重三倍的食物。取食處會明顯出現大量黏稠、濕潤之糞便，此會促成較高的疾病壓力，藉此對該處的植物造成繼發性的問題。已知其對數種某些殺蟲劑有抗藥性。Brassica chinensis is a serious pest that can be found all over the world. It attacks alfalfa, beans, beets, broccoli, kale, cabbage, cantaloupe, broccoli, celery, collard, cotton, cucumber, eggplant, kale, lettuce, melon, mustard, Parsley, peas, pepper, potato, soybean, spinach, pumpkin, tomato, turnip and watermelon, and other crops. This species is very destructive to plants due to its greedy appetite. Larvae eat three times their weight every day. A large amount of sticky, moist feces will appear in the feeding place, which will lead to higher disease stress, which will cause secondary problems in the plants. It is known to be resistant to several insecticides.

因此，基於上述因素，此等害蟲之控制係重要的。而且，控制此等已知為嚼食性害蟲之害蟲(BAW及CL)之分子，可用於控制嚼食植物之其他害蟲。Therefore, based on the above factors, the control of such pests is important. Moreover, molecules that control these pests known as chewing pests (BAW and CL) can be used to control other pests of chewing plants.

本文件中揭示之某些分子係使用下列實施例中所述之程序，來測試其對抗BAW與CL之能力。有關結果之報導，使用“BAW & CL 分級表 ” (參見表格部分)。對 BAW 進行之生物分析 Certain of the molecules disclosed in this document use the procedures described in the following examples to test their ability to combat BAW and CL. For reporting of results, use the “ BAW & CL Rating Table ” (see the table section). Biological analysis of BAW

對BAW之生物分析係使用128孔之食物盤分析進行。將一至五隻第二齡期之BAW幼蟲置於食物盤之每一孔(3毫升)，此食物盤已事先填充1毫升之人工食物，已施加50 μg/cm2 之測試分子(溶於50 μL之90：10丙酮-水之混合物)(至八個孔之每一者)，之後讓其乾燥。盤係以一透明自黏性覆蓋物覆蓋，開孔以允許氣體交換，且於25℃，14：10亮-暗下保持五至七天。記錄每一孔之幼蟲死亡率百分比；接著將八個孔中之活性求平均值。結果在標題為「表 ABC ： 生物分析 結果 」(參見表格部分)之表中示出。對 CL 進行之生物分析 The BAW bioassay was performed using a 128-well food plate analysis. Place one to five second-instar BAW larvae in each well (3 ml) of the food tray. This food tray has been filled with 1 ml of artificial food beforehand, and 50 μg/cm 2 of test molecules have been applied (dissolved in 50). 90 μL of a mixture of acetone and water (to each of the eight wells), then allowed to dry. The trays were covered with a clear self-adhesive cover, perforated to allow gas exchange, and held at 25 ° C, 14:10 light-dark for five to seven days. The percentage of larval mortality per well was recorded; the activity in the eight wells was then averaged. The results are shown in the table entitled " Table ABC : Bioanalytical Results " (see table section). Biological analysis of CL

對CL之生物分析係使用128孔之食物盤分析進行。將一至五隻第二齡期之CL幼蟲置於食物盤之每一孔(3毫升)，此食物盤已事先填充1毫升之人工食物，已施加50 μg/cm2 之測試分子(溶於50 μL之90：10丙酮-水之混合物)(至八個孔之每一者)，之後讓其乾燥。盤係以一透明自黏性覆蓋物覆蓋，開孔以允許氣體交換，且於25 ℃，14：10亮-暗下保持五至七天。記錄每一孔之幼蟲死亡率百分比；接著將八個孔中之活性求平均值。結果在標題為「表 ABC ： 生物分析 結果 」(參見表格部分)之表中示出。實施例B ：對黃熱病蚊( 埃及斑蚊(Aedes aegypti ， AEDSAE) (“YFM”))) 進行 之 生物分析 The biological analysis of CL was performed using a 128-well food plate analysis. Place one to five second-instar CL larvae in each well (3 ml) of the food tray. This food tray has been filled with 1 ml of artificial food beforehand, and 50 μg/cm 2 of test molecules have been applied (dissolved in 50 90 μL of a mixture of acetone and water (to each of the eight wells), then allowed to dry. The trays were covered with a clear self-adhesive covering, open to allow gas exchange, and held at 25 ° C, 14:10 light-dark for five to seven days. The percentage of larval mortality per well was recorded; the activity in the eight wells was then averaged. The results are shown in the table entitled " Table ABC : Bioanalytical Results " (see table section). Example B: Analysis of the yellow fever mosquito (Aedes aegypti (Aedes aegypti, AEDSAE) ( " YFM"))) for a creature

YFM喜歡在白天叮咬人類，且最常在人類居住處或附近被發現。YFM為傳播數種疾病之媒介。YFM為一種可傳播登革熱與黃熱病毒之蚊子。黃熱病是第二危險之蚊子傳播疾病，僅次於瘧疾。黃熱病為急性病毒出血性疾病，且未接受治療之嚴重病患至多有高達50%會死於黃熱病。預計每年全球會有200,000個黃熱病病例，導致30,000人死亡。登革熱是一種討厭的病毒性疾病；由於其會產生劇烈疼痛，所以有時稱為"關節痛熱"或"心臟痛熱"。登革熱每年造成約20,000人死亡。因此，上述控制此害蟲之因子相當重要。此外，控制此已知為吸食性害蟲的害蟲(YFM)之分子，可用於控制患病的人類與動物體內其他的吸食性害蟲。YFM likes to bite humans during the day and is most often found in or near human settlements. YFM is a medium for the transmission of several diseases. YFM is a mosquito that can transmit dengue and yellow fever viruses. Yellow fever is the second most dangerous mosquito-borne disease, second only to malaria. Yellow fever is an acute viral hemorrhagic disease, and up to 50% of serious patients who have not received treatment will die from yellow fever. It is estimated that there will be 200,000 cases of yellow fever worldwide each year, resulting in 30,000 deaths. Dengue fever is an unpleasant viral disease; it is sometimes called "joint pain fever" or "heart pain fever" because it produces severe pain. Dengue fever kills about 20,000 people each year. Therefore, the above factors controlling this pest are quite important. In addition, the control of this known fungus pest (YFM) molecule can be used to control diseased humans and other ingestive pests in animals.

本文件中揭示之某些分子係使用下列段落中所述之程序，來測試其對抗YFM之能力。有關結果之報導，使用“YFM 分級表 ”(參見表格部分)。Certain of the molecules disclosed in this document use the procedures described in the following paragraphs to test their ability to combat YFM. For the reporting of results, use the “ YFM Rating Table ” (see the table section).

使用含有400 µg分子，其溶於100 µL二甲基亞碸(DMSO)中(相當於4000 ppm溶液)之主盤。組合的分子之主盤每孔含有15 µL。在此盤中，每孔加入135 µL之90:10水/丙酮混合物。機器人(Biomek® NXP Laboratory Automation Workstation)設定程式由主盤中分配15 µL吸取液至空的96-孔淺盤中(“子”盤)。每主盤產生6 reps(“子”盤)。產生之“子”盤之後立即經YFM幼蟲感染。A master disk containing 400 μg of molecule dissolved in 100 μL of dimethyl sulfoxide (DMSO) (equivalent to 4000 ppm solution) was used. The master of the combined molecule contains 15 μL per well. In this dish, 135 μL of a 90:10 water/acetone mixture was added to each well. The robot (Biomek® NXP Laboratory Automation Workstation) setup program allocates 15 μL of aspirate from the master to an empty 96-well tray (“child” tray). 6 reps ("sub" disk) per master. Immediately after the "child" disk is produced, it is infected by YFM larvae.

在該盤處理前一日，將蚊子卵置於含有肝粉末之Millipore水中，開始孵化(4 g.至400 mL中)。在使用機器人製備“子”盤後，以220 µL肝粉末/蚊幼蟲混合物(約1天大的幼蟲)感染子盤。該盤經蚊幼蟲感染後，使用非揮發性的上蓋覆蓋該盤，以降低乾燥情況。盤於室溫下維持3天，之後分級。3天後，觀察每一孔並依據死亡率評分。結果在標題為「表 ABC ： 生物分析 結果 」(參見表格部分)之表中示出。農業上可接受的酸加成鹽類、鹽類衍生物、溶劑合物、酯類衍生物、多形體、同位素與放射性核種 On the day before the dish was treated, the mosquito eggs were placed in Millipore water containing liver powder and incubation was started (4 g. to 400 mL). After the "child" disk was prepared using a robot, the sub-plate was infected with 220 μL of liver powder/mosquito larvae mixture (about 1 day old larva). After the disc is infected by mosquito larvae, the disc is covered with a non-volatile cover to reduce drying. The plate was maintained at room temperature for 3 days and then fractionated. After 3 days, each well was observed and scored according to mortality. The results are shown in the table entitled " Table ABC : Bioanalytical Results " (see table section). Agriculturally acceptable acid addition salts, salt derivatives, solvates, ester derivatives, polymorphs, isotopes and radionuclides

式1分子可以調配成農業上可接受的酸加成鹽類。作為非限制性例子，胺官能基可與氫氯酸、氫溴酸、硫酸、磷酸、乙酸、苯甲酸、檸檬酸、丙二酸、水楊酸、蘋果酸、福馬酸、草酸、琥珀酸、酒石酸、乳酸、葡萄糖酸、抗壞血酸、馬來酸、天冬門酸、苯磺酸、甲磺酸、乙磺酸、羥甲磺酸，及羥乙磺酸形成鹽類。另外，作為非限制性例子，酸官能基可形成鹽類，包括自鹼金屬或鹼土金屬衍生及自氨及胺衍生者。陽離子之較佳例子可包括鈉、鉀，及鎂。The molecule of formula 1 can be formulated into an agriculturally acceptable acid addition salt. As a non-limiting example, the amine functional group can be combined with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, acetic acid, benzoic acid, citric acid, malonic acid, salicylic acid, malic acid, fumaric acid, oxalic acid, succinic acid, Tartaric acid, lactic acid, gluconic acid, ascorbic acid, maleic acid, aspartic acid, benzenesulfonic acid, methanesulfonic acid, ethanesulfonic acid, hydroxamic acid, and isethionate form salts. Additionally, as a non-limiting example, acid functional groups can form salts, including those derived from alkali or alkaline earth metals and derived from ammonia and amines. Preferred examples of the cation may include sodium, potassium, and magnesium.

式1分子可以調配成鹽衍生物。作為非限制性例子，鹽衍生物可藉由使游離鹼與足夠量之所欲酸接觸產生鹽而製備。游離鹼可藉由將此鹽以適合的稀釋鹼水溶液處理而再生，鹼水溶液諸如稀釋的氫氧化鈉、碳酸鉀、氨，及碳酸氫鈉水溶液。作為許多案例中之範例，一種殺蟲劑如2,4-D，可藉由將其轉化為其二甲基胺鹽類而更具水溶性。The molecule of formula 1 can be formulated as a salt derivative. As a non-limiting example, a salt derivative can be prepared by contacting a free base with a sufficient amount of the desired acid to produce a salt. The free base can be regenerated by treating the salt with a suitable aqueous dilute solution such as dilute sodium hydroxide, potassium carbonate, ammonia, and aqueous sodium bicarbonate. As an example in many cases, an insecticide such as 2,4-D can be more water soluble by converting it to its dimethylamine salt.

式1分子可以與溶劑調配成穩定的錯合物，從而使該錯合物在移除未錯合的溶劑後仍保持完整。此等錯合物通常被稱為「溶劑合物」。然而，較佳以水作為溶劑形成穩定的水合物。The molecule of Formula 1 can be formulated with a solvent to form a stable complex such that the complex remains intact after removal of the solvent that is not mismatched. Such complexes are often referred to as "solvates." However, it is preferred to form a stable hydrate with water as a solvent.

含酸官能之式1分子可製備為酯類衍生物。這些酯類衍生物繼而可以類似於本文件揭示之分子的應用方式應用。The molecule of formula 1 containing an acid function can be prepared as an ester derivative. These ester derivatives can then be applied in a manner similar to the application of the molecules disclosed in this document.

式1分子可製備為各種結晶性多形體。多形性於發展農用化學品上係重要的，因為相同分子之不同結晶多形體或結構的具有的不同的物理性質及生物效能。The molecule of Formula 1 can be prepared as various crystalline polymorphs. Polymorphism is important in the development of agrochemicals because of the different physical properties and biological potencies of different crystalline polymorphs or structures of the same molecule.

式1分子可以用不同的同位素來製造。尤其重要的為具有2 H(亦稱為氘)或是3H(亦稱為氚)取代1 H之分子。式1分子可以用不同的放射性核種來製造。尤其重要的為具有14 C(亦稱為放射性碳)之分子。具有氘、氚、或是14 C取代之式1分子可以使用於生物研究，能夠追蹤化學及物理製程及半衰期研究，以及MoA研究。組合 The molecule of formula 1 can be made with different isotopes. Of particular importance are molecules having 2 H (also known as hydrazine) or 3H (also known as hydrazine) in place of 1 H. Molecules of Formula 1 can be made from different radionuclides. Of particular importance are molecules having 14 C (also known as radiocarbon). Formula 1 with hydrazine, hydrazine, or 14 C substitution can be used in biological research to track chemical and physical processes and half-life studies, as well as MoA studies. combination

在本發明之另一個具體例中，式1分子可與一種或多種活性成分組合使用(諸如，呈組成混合物之形式，或同時或依序施用)。In another embodiment of the invention, the molecule of Formula 1 can be used in combination with one or more active ingredients (such as in the form of a mixture of ingredients, or simultaneously or sequentially).

在本發明之另一個具體例中，式1分子可與一種或多種活性成分組合使用(諸如，呈組成混合物之形式，或同時或依序施用)，該活性成分每一者皆具有與式1分子之作用模式(“MoA”)相同、類似但是更可能為-相異之MoA。In another embodiment of the invention, the molecule of Formula 1 can be used in combination with one or more active ingredients (such as in the form of a mixture of ingredients, or simultaneously or sequentially), each of which has Formula 1 The mode of action of the molecules ("MoA") is the same, similar but more likely to be - different.

在另一個具體例中，式1分子可與一種或多種分子組合使用(諸如，呈組成混合物之形式，或同時或依序施用)，該一種或多種分子具有殺蜱蟎、殺藻、殺卵、殺菌、殺真菌、除草、殺昆蟲、殺軟體動物、殺線蟲、滅鼠及/或殺病毒特性。In another embodiment, the molecule of Formula 1 can be used in combination with one or more molecules (such as in the form of a mixture of compounds, or simultaneously or sequentially) having killing, algicidal, and egg killing. , bactericidal, fungicidal, herbicidal, insecticidal, molluscicidal, nematicidal, rodent and/or virucidal properties.

在另一個具體例中，式1分子可與一種或多種分子組合使用(諸如，呈組成混合物之形式，或同時或依序施用)，該一種或多種分子為拒食劑、驅鳥劑、化學絕育劑、除草劑安全劑、誘蟲劑、驅蟲劑、驅哺乳動物劑、交配干擾劑、植物活化劑、植物生長調節劑及/或協力劑。In another embodiment, the molecule of Formula 1 can be used in combination with one or more molecules (such as in the form of a mixture of compositions, or simultaneously or sequentially), the one or more molecules being antifeedants, bird repellents, chemical sterilization Agents, herbicide safeners, insecticides, insect repellents, mammalian agents, mating interferers, plant activators, plant growth regulators and/or synergists.

在另一個具體例中，式1分子可與一種或多種生物性殺蟲劑組合使用(諸如，呈組成混合物之形式，或同時或依序施用)。In another embodiment, the molecule of Formula 1 can be used in combination with one or more biological insecticides (such as in the form of a mixture of ingredients, or simultaneously or sequentially).

在另一個具體例中，式1分子與活性成分之殺蟲組成物組合可以廣大變化範圍之重量比使用。舉例而言，二組分混合物，式1分子比活性成分之重量比，可以使用表B中的重量比。然而，一般而言，重量比小於約10:1至約1:10為較佳的。有時使用包含一種三、四、五、六、七、或更多組分的混合物亦為較佳的，該混合物包含式1分子及額外的二或三種活性成分。In another embodiment, the combination of the molecule of Formula 1 with the pesticidal composition of the active ingredient can be used in a wide range of weight ratios. For example, the weight ratio of the two component mixture, the molecular weight of the formula 1 to the active ingredient, can be used in the weight ratio in Table B. Generally, however, a weight ratio of less than about 10:1 to about 1:10 is preferred. It is also preferred to use a mixture comprising one, three, four, six, seven, or more components comprising a molecule of formula 1 and an additional two or three active ingredients.

式1分子與一種活性成分之重量比可以描述為X:Y ；其中X 為式1之分子的重量份且Y 為活性成分之重量份。X 重量份之數值範圍為0 ＜X ≤ 100且Y 重量份之數值範圍為0 ＜Y ≤ 100，以及通過圖表顯示於表C 中。作為非限制性實例，式1之分子與一種活性成分之重量比範圍可以為20:1。The weight ratio of the molecule of formula 1 to an active ingredient can be described as X:Y ; wherein X is part by weight of the molecule of formula 1 and Y is part by weight of the active ingredient. The value of X parts by weight is in the range of 0 < X ≤ 100 and the value of Y parts by weight is 0 < Y ≤ 100, and is shown in Table C by a graph. As a non-limiting example, the weight ratio of the molecule of Formula 1 to an active ingredient can range from 20:1.

式1分子與一種活性成分之重量比範圍可以描述為X1 ：Y1 至X2 ：Y2 ，其中X 及Y 如上文所定義。The weight ratio range of the molecule of formula 1 to an active ingredient can be described as X 1 : Y 1 to X 2 : Y 2 , wherein X and Y are as defined above.

在一個具體例中，重量比範圍可為X1 ：Y1 至X2 ：Y2 ，其中X1 ＞Y1 且X2 ＜Y2 。作為非限制性實例，式1分子與一種活性成分之重量比範圍可在約3：1與約1：3之間，含括端點。In one embodiment, the weight ratio may range from X 1 : Y 1 to X 2 : Y 2 , where X 1 > Y 1 and X 2 < Y 2 . As a non-limiting example, the weight ratio of the molecule of Formula 1 to an active ingredient can range between about 3:1 and about 1:3, inclusive.

在另一個具體例中，重量比範圍可為X1 ：Y1 至X2 ：Y2 ，其中X1 ＞Y1 且X2 ＞Y2 。作為非限制性實例，式1分子與一種活性成分之重量比範圍可在約15：1與約3：1之間，含括端點。In another embodiment, the weight ratio may range from X 1 : Y 1 to X 2 : Y 2 , where X 1 > Y 1 and X 2 > Y 2 . As a non-limiting example, the weight ratio of the molecule of Formula 1 to an active ingredient can range between about 15:1 and about 3:1, inclusive.

在另一個具體例中，重量比範圍可為X1 ：Y1 至X2 ：Y2 ，其中X1 ＜Y1 且X2 ＜Y2 。作為非限制性實例，式1分子與一種活性成分之重量比範圍可在約1：3與約1：20之間，含括端點。In another embodiment, the weight ratio may range from X 1 : Y 1 to X 2 : Y 2 , where X 1 < Y 1 and X 2 < Y 2 . As a non-limiting example, the weight ratio of the molecule of Formula 1 to an active ingredient can range between about 1:3 and about 1:20, inclusive.

如表B及C中所呈現，式1分子與一種活性成分之某些重量比，可以想見為協同性的。調配物 As shown in Tables B and C, certain weight ratios of the molecule of Formula 1 to an active ingredient are conceivable as synergistic. Formulation

殺蟲劑常常不適合以單純形式使用。通常需要添加其他物質，以便該殺蟲劑能以允許方便施用、處理、輸送、儲存及最大殺蟲劑活性之所需濃度及適宜形式使用。因此，殺蟲劑係調配成例如餌劑、濃縮乳劑、粉劑、可乳化性濃縮液、燻蒸劑、膠劑、粒劑、微膠囊、種子處理劑、懸浮濃縮劑、懸乳劑(suspoemulsion)、錠劑、水溶性液劑、水分散性粒劑或是乾燥可流動劑、可濕性粉劑及超低體積溶液。Insecticides are often not suitable for use in pure form. It is often desirable to add other materials so that the pesticide can be used in a desired concentration and in a suitable form that allows for convenient application, handling, transport, storage, and maximum insecticidal activity. Therefore, the insecticide is formulated into, for example, a bait, a concentrated emulsion, a powder, an emulsifiable concentrate, a fumigant, a gel, a granule, a microcapsule, a seed treatment, a suspension concentrate, a suspoemulsion, an ingot. Agent, water-soluble liquid agent, water-dispersible granule or dry flowable agent, wettable powder and ultra-low volume solution.

殺蟲劑最經常以由此等殺蟲劑的濃縮調配物所製備之含水懸浮液或乳劑的形式來施用。此等水溶性、水可懸浮或可乳化調配物為固體，通常稱為可濕性粉末、水可分散顆粒，或者為液體，通常稱為可乳化濃縮物或水性懸浮液。可濕性粉末，其可經壓緊以形成水可分散顆粒，包含殺蟲劑、載劑及界面活性劑之緊密混合物。殺蟲劑之濃度通常為約10重量%至約90重量%。載劑通常選自鎂鋁海泡石黏土(attapulgite clay)、蒙脫石黏土(montmorillonite clay)、矽藻土(diatomaceous earth)或純化矽酸鹽。包含約0.5%至約10%的可濕性粉劑之有效界面活性劑，見於磺酸化木質素、縮合萘磺酸鹽、萘磺酸鹽、烷基苯磺酸鹽、烷基硫酸鹽以及非離子性界面活性劑，諸如烷基苯酚的環氧乙烷加成物。Insecticides are most often applied in the form of aqueous suspensions or emulsions prepared from concentrated formulations of such insecticides. Such water soluble, water suspendable or emulsifiable formulations are solids, commonly referred to as wettable powders, water dispersible granules, or liquids, commonly referred to as emulsifiable concentrates or aqueous suspensions. A wettable powder which can be compacted to form water dispersible granules comprising an intimate mixture of an insecticide, a carrier and a surfactant. The concentration of the pesticide is usually from about 10% by weight to about 90% by weight. The carrier is typically selected from the group consisting of attapulgite clay, montmorillonite clay, diatomaceous earth or purified citrate. An effective surfactant comprising from about 0.5% to about 10% of a wettable powder, found in sulfonated lignin, condensed naphthalene sulfonate, naphthalene sulfonate, alkyl benzene sulfonate, alkyl sulfate, and nonionic A surfactant such as an ethylene oxide adduct of an alkyl phenol.

殺蟲劑之可乳化濃縮物包含溶解於載劑中合宜濃度之殺蟲劑，諸如每公升液體約50至約500公克，該載劑為水可混溶的溶劑或水不混溶的有機溶劑及乳化劑之混合物。適用的有機溶劑包括芳族類，尤其是二甲苯類與石油分餾物，尤其是石油的高沸點萘與烯烴部分，諸如重芳族石油腦。亦可使用其他有機溶劑，諸如包括松香衍生物在內之萜烯溶劑、脂族酮類諸如環己酮，及複合醇類諸如2-乙氧基乙醇。用於可乳化性濃縮液之適宜乳化劑係選自習用的陰離子性及非離子性界面活性劑。The emulsifiable concentrate of the insecticide comprises a pesticidal agent dissolved in a suitable concentration in the carrier, such as from about 50 to about 500 grams per liter of liquid, the carrier being a water-miscible solvent or a water-immiscible organic solvent. And a mixture of emulsifiers. Suitable organic solvents include aromatics, especially xylenes and petroleum fractions, especially high boiling naphthalene and olefin fractions of petroleum, such as heavy aromatic petroleum brains. Other organic solvents such as a terpene solvent including a rosin derivative, an aliphatic ketone such as cyclohexanone, and a complex alcohol such as 2-ethoxyethanol may also be used. Suitable emulsifiers for the emulsifiable concentrate are selected from the customary anionic and nonionic surfactants.

水性懸浮液包含以在約5重量%至約50重量%範圍內之濃度，分散在水性載劑中之非水溶性殺蟲劑的懸浮液。懸浮液藉由以下方式製備：精細研磨殺蟲劑並將其劇烈混合至載劑中，該載劑包含水及界面活性劑。亦可添加諸如無機鹽及合成膠或天然膠之成分，從而增加水性載劑之密度及黏度。通常最有效的為藉由以儀器，諸如砂磨機、球磨機或活塞型均質器中製備水性混合物並對其進行均質化來同時研磨及混合殺蟲劑。懸浮液內的殺蟲劑可以予以微膠囊化於塑膠聚合物中。The aqueous suspension comprises a suspension of a water-insoluble pesticide dispersed in an aqueous carrier at a concentration ranging from about 5% by weight to about 50% by weight. The suspension is prepared by finely grinding the insecticide and vigorously mixing it into a carrier comprising water and a surfactant. Additives such as inorganic salts and synthetic or natural gums may also be added to increase the density and viscosity of the aqueous carrier. It is generally most effective to simultaneously grind and mix the pesticide by preparing and homogenizing the aqueous mixture in an instrument such as a sand mill, a ball mill or a piston type homogenizer. The insecticide in the suspension can be microencapsulated in a plastic polymer.

油分散液(OD)包含以在約2重量%至約50重量%範圍內之濃度，微細地分散在有機溶劑及乳化劑之混合物中之非有機溶劑溶性殺蟲劑的懸浮液。一種或多種殺蟲劑可以溶解於有機溶劑中。適用的有機溶劑包括芳族類，尤其是二甲苯類與石油分餾物，尤其是石油的高沸點萘與烯烴部分，諸如重芳族石油腦。亦可使用其他有機溶劑，包括蔬菜油、種子油及植物油與種子油之酯類。用於油分散液之適宜乳化劑係選自習用的陰離子性及非離子性界面活性劑。油分散液調配物內添加增稠劑或膠凝劑，以改變液體之流變學或流動性質及防止分散粒子或液滴之分離及沈降。The oil dispersion (OD) comprises a suspension of a non-organic solvent-soluble insecticide which is finely dispersed in a mixture of an organic solvent and an emulsifier at a concentration ranging from about 2% by weight to about 50% by weight. One or more insecticides can be dissolved in an organic solvent. Suitable organic solvents include aromatics, especially xylenes and petroleum fractions, especially high boiling naphthalene and olefins of petroleum, such as heavy aromatic petroleum brains. Other organic solvents may also be used, including vegetable oils, seed oils, and esters of vegetable oils and seed oils. Suitable emulsifiers for the oil dispersion are selected from the customary anionic and nonionic surfactants. A thickener or gelling agent is added to the oil dispersion formulation to alter the rheology or flow properties of the liquid and to prevent separation and precipitation of dispersed particles or droplets.

殺蟲劑亦可以顆粒組成物之形式來施用，該等顆粒組成物尤其適用於施用至土壤中。顆粒組成物通常含有分散在載劑中之約0.5重量%至約10重量%之殺蟲劑，該載劑包含黏土或相似物質。該等組成物通常藉由以下方式製備：將該殺蟲劑溶解在適合之溶劑中並將其施用至顆粒載劑上，該顆粒載劑已經預成形為適當粒徑，在約0.5mm至約3mm範圍內。此等組成物亦可藉由以下方式調配：將該載劑及分子製成麵團狀或糊狀，然後壓碎並乾燥，從而得到所需顆粒粒徑。另一種顆粒為水可乳化顆粒(EG)。其為由以傳統的活性成分之水包油乳液方式施用之顆粒組成的調配物，於崩散或溶解於水中之後，溶解或稀釋於有機溶劑內。水可乳化顆粒含有一種或數種溶解或稀釋於合適的有機溶劑內之活性成分，其被聚合殼體或一些其他類型的可溶性或不溶性基質吸收。The insecticides can also be applied in the form of a particulate composition which is especially suitable for application to the soil. The particulate composition typically contains from about 0.5% to about 10% by weight of the pesticide dispersed in the carrier, the carrier comprising clay or the like. Such compositions are typically prepared by dissolving the pesticide in a suitable solvent and applying it to a particulate carrier which has been preformed to a suitable particle size, from about 0.5 mm to about Within 3mm range. These compositions may also be formulated by forming the carrier and the molecule into a dough or paste, then crushing and drying to obtain the desired particle size. Another type of particle is water emulsifiable particles (EG). It is a formulation consisting of particles applied as an oil-in-water emulsion of a conventional active ingredient, dissolved or diluted in an organic solvent after being disintegrated or dissolved in water. The water emulsifiable granules contain one or more active ingredients dissolved or diluted in a suitable organic solvent which are absorbed by the polymeric shell or some other type of soluble or insoluble matrix.

含有殺蟲劑之塵劑係藉由以下方式製備：將呈粉末形式之殺蟲劑與適合之粉塵狀農業載劑，諸如高嶺黏土、經研磨火山岩及其類似載劑，緊密混合。塵劑可適當地含有約1%至約10%的殺蟲劑。塵劑可以施用作為拌種(seed dressing)或以粉塵鼓風機施用於葉片上。Dust containing insecticides are prepared by intimately mixing the pesticide in powder form with a suitable dusty agricultural vehicle such as kaolin clay, ground volcanic rock and the like. The dusting agent may suitably contain from about 1% to about 10% of the pesticide. The dust can be applied as a seed dressing or applied to the blade by a dust blower.

同樣可行的以配於適當有機溶劑中的溶液形式施用之殺蟲劑，該有機溶劑通常為石油諸如噴霧油，該有機溶劑廣泛用於農業化學。It is also possible to apply the insecticide in the form of a solution in a suitable organic solvent, typically a petroleum such as a spray oil, which is widely used in agrochemicals.

殺蟲劑亦可以氣溶膠組成物之形式來施用。在此等組成物中，將殺蟲劑溶解或分散在載劑中，該載劑為產生壓力之推進劑混合物。將氣溶膠組成物包裝在容器中，該混合物經由霧化閥而自該容器噴散。The insecticide can also be applied in the form of an aerosol composition. In such compositions, the pesticide is dissolved or dispersed in a carrier which is a pressurized propellant mixture. The aerosol composition is packaged in a container that is sprayed from the container via an atomizing valve.

當將殺蟲劑與食物或引誘劑或兩者混合時，形成殺蟲劑誘餌。當害蟲吃掉誘餌時，其等亦攝入殺蟲劑。誘餌可呈顆粒、凝膠、可流動粉末、液體或固體形式。誘餌可用於害蟲藏身處。When the pesticide is mixed with food or an attractant or both, an insecticide bait is formed. When the pest eats the bait, it also ingests the pesticide. The bait can be in the form of granules, gels, flowable powders, liquids or solids. The bait can be used to hide the pests.

薰蒸劑為具有相對較高蒸氣壓之殺蟲劑，且因此可以濃度足以殺死土壤或密封空間中之害蟲的氣體形式存在。薰蒸劑之毒性與其濃度及曝露時間成比例。其等特徵在於具有良好的擴散能力，並藉由滲透至害蟲之呼吸系統中或經由害蟲之表皮吸收而起作用。施用薰蒸劑以便在氣密房間或建築物中或在專門腔室中，對防氣片(gas proof sheet)下之儲藏產品害蟲進行控制。The fumigant is an insecticide having a relatively high vapor pressure and thus can be present in a gas form at a concentration sufficient to kill the pest in the soil or sealed space. The toxicity of the fumigant is proportional to its concentration and exposure time. It is characterized by having good diffusion ability and acting by infiltrating into the respiratory system of the pest or by absorption from the epidermis of the pest. The fumigant is applied to control the stored product pests under the gas proof sheet in an airtight room or building or in a specialized chamber.

可藉由將殺蟲劑粒子或小滴懸浮在各種類型之塑膠聚合物中，而將殺蟲劑微膠囊化。藉由改變聚合物之化學性質或藉由改變加工中之因素，可形成各種大小、溶解度、壁厚度及滲透度之微膠囊。此等因素控制其中活性成分之釋放速度，而釋放速度又影響產品之殘留效能、作用速度及氣味。微膠囊可調配為懸浮濃縮劑或是水可分散顆粒。The insecticide can be microencapsulated by suspending the pesticide particles or droplets in various types of plastic polymers. Microcapsules of various sizes, solubilities, wall thicknesses, and permeability can be formed by altering the chemical nature of the polymer or by varying the factors in processing. These factors control the rate of release of the active ingredient, which in turn affects the residual performance, speed of action and odor of the product. The microcapsules can be formulated as suspension concentrates or water dispersible granules.

油溶液濃縮物係藉由將殺蟲劑溶於一溶劑內而製備，該溶劑會將殺蟲劑留置於溶液中。殺蟲劑之油溶液由於溶劑本身具有殺蟲作用及溶解體被之蠟質覆蓋物而增加殺蟲劑的攝取速度，所以通常會提供比其他調配物更快的擊倒及殺死害蟲作用。油溶液之其他優點包括較好的儲藏穩定性、更好的裂縫滲透性及更好的油膩表面黏附性。The oil solution concentrate is prepared by dissolving the insecticide in a solvent which will leave the pesticide in solution. The insecticide oil solution generally provides faster knockdown and killing of pests than other formulations because the solvent itself has an insecticidal action and the dissolved body is covered with a waxy cover to increase the rate of insecticide uptake. Other advantages of the oil solution include better storage stability, better crack penetration, and better greasy surface adhesion.

另一具體例為一種水包油型乳劑，其中該乳劑包含油性小球，該等油性小球各自提供有層狀液晶塗層，並分散在水相中，其中各油性小球包含至少一種具有農業活性之分子，並個別地塗佈有單層狀或寡層狀之層，該層包含：(1)至少一種非離子性親脂性界面活性劑，(2)至少一種非離子性親水性界面活性劑，及(3)至少一種離子性界面活性劑，其中該等小球具有小於800奈米之平均粒徑。其他調配物組分 Another specific example is an oil-in-water emulsion, wherein the emulsion comprises oily pellets, each of which is provided with a layered liquid crystal coating and dispersed in an aqueous phase, wherein each of the oily pellets comprises at least one of An agriculturally active molecule, individually coated with a monolayer or oligo layer, comprising: (1) at least one nonionic lipophilic surfactant, and (2) at least one nonionic hydrophilic interface An active agent, and (3) at least one ionic surfactant, wherein the pellets have an average particle size of less than 800 nanometers. Other formulation components

一般而言，當式1揭示之分子使用於一調配物中時，此調配物亦可含有其他組分。此等組分包括但不限於(其係ㄧ個非詳盡無遺及非互相排除的清單)濕潤劑、展佈劑、黏著劑、滲透劑、緩衝劑、螯合劑、漂浮降低劑、相容劑、消泡劑、清潔劑及乳化劑。現即說明一些組分。In general, when the molecule disclosed in Formula 1 is used in a formulation, the formulation may also contain other components. Such components include, but are not limited to, (a list of non-exhaustive and non-exclusive list) humectants, spreaders, adhesives, penetrants, buffers, chelating agents, float lowering agents, compatibilizers, Defoamer, detergent and emulsifier. Some components are now explained.

潤濕劑係ㄧ物質，當添加至一液體時，藉由降低該液體與其展佈表面之間的界面張力而增加該液體的展佈或滲透力。潤濕劑用於農業化學調配物中之兩種主要功能：在處理及製造期間增加粉末在水中之潤濕速率，從而製造可溶性液體之濃縮物或懸浮濃縮物；及在產品與水在噴霧罐中混合期間降低可濕性粉末之潤濕時間，並使水滲透進入水可分散顆粒中的情況改善。用於可濕性粉末、懸浮濃縮物及水可分散顆粒調配物中的潤濕劑之實例為：月桂基硫酸鈉；二辛基磺基丁二酸鈉；烷基酚乙氧化物；及脂族醇乙氧化物。The wetting agent is a cerium material that, when added to a liquid, increases the spreading or penetration of the liquid by reducing the interfacial tension between the liquid and its spreading surface. Wetting agents are used in two main functions in agrochemical formulations: increasing the rate of wetting of the powder in water during processing and manufacturing to produce a soluble liquid concentrate or suspension concentrate; and in the product with water in a spray can The wetting time of the wettable powder is lowered during the middle mixing, and the penetration of water into the water-dispersible particles is improved. Examples of wetting agents for use in wettable powders, suspension concentrates and water dispersible granule formulations are: sodium lauryl sulfate; sodium dioctyl sulfosuccinate; alkyl phenol ethoxylates; Alcohol ethoxylate.

分散劑為吸附至粒子表面上、有助於保持粒子之分散狀態以及防止粒子重新聚集的物質。將分散劑添加至農業化學調配物中以有助於製造期間之分散及懸浮，並且有助於確保粒子在噴霧罐中重新分散至水中。其廣泛用於可濕性粉末、懸浮濃縮物及水可分散顆粒中。用作分散劑之界面活性劑具有牢固吸附至粒子表面上之能力，並對粒子重新聚集提供電荷或空間障壁。最常用的界面活性劑為陰離子型、非離子型或該等兩種類型之混合物。對於可濕性粉末調配物，最常用分散劑為木質素磺酸鈉。對於懸浮濃縮物而言，使用聚電解質，諸如鈉-萘磺酸鹽-甲醛-濃縮物來得到極好的吸附及穩定。亦使用三苯乙烯基苯酚乙氧化物磷酸酯。非離子物，諸如烷基芳基氧化乙烯濃縮物及EO-PO嵌段共聚物，有時與陰離子物組合起來作為用於懸浮濃縮物之分散劑。近年來，新型式之極高分子量聚合物界面活性劑已開發作為分散劑。此等具有極長之疏水性『主鏈』及大量氧化乙烯鏈，其形成『梳狀』界面活性劑之『齒』。此等高分子量聚合物可對懸浮濃縮物產生極好的長期穩定性，因為疏水性主鏈對粒子表面具有許多錨定點。用於農業化學調配物之分散劑之實例為：木質素磺酸鈉；萘磺酸鈉甲醛濃縮物；三苯乙烯基苯酚-乙氧化物-磷酸-酯；脂族醇乙氧化物；烷基乙氧化物；EO-PO嵌段共聚物；以及接枝共聚物。The dispersant is a substance that adsorbs onto the surface of the particles, helps to maintain the dispersed state of the particles, and prevents the particles from re-aggregating. The dispersant is added to the agrochemical formulation to aid dispersion and suspension during manufacture and to help ensure that the particles are redispersed into the water in the spray can. It is widely used in wettable powders, suspension concentrates and water-dispersible granules. The surfactant used as a dispersing agent has the ability to adhere strongly to the surface of the particles and to provide charge or space barriers for particle re-aggregation. The most commonly used surfactants are anionic, nonionic or a mixture of these two types. For wettable powder formulations, the most commonly used dispersant is sodium lignosulfonate. For suspension concentrates, polyelectrolytes, such as sodium-naphthalenesulfonate-formaldehyde-concentrates, are used to obtain excellent adsorption and stabilization. Tristyrylphenol ethoxylate phosphate is also used. Nonionics, such as alkyl aryl ethylene oxide concentrates and EO-PO block copolymers, are sometimes combined with anionics as a dispersing agent for suspending concentrates. In recent years, new types of very high molecular weight polymer surfactants have been developed as dispersants. These have extremely long hydrophobic "main chain" and a large number of oxyethylene chains, which form the "tooth" of the "comb" surfactant. These high molecular weight polymers provide excellent long term stability to the suspension concentrate because the hydrophobic backbone has many anchor points to the particle surface. Examples of dispersants for use in agrochemical formulations are: sodium lignosulfonate; sodium naphthalenesulfonate formaldehyde concentrate; tristyrylphenol-ethoxylate-phosphoric acid ester; aliphatic alcohol ethoxylate; alkyl Ethoxylate; EO-PO block copolymer; and graft copolymer.

乳化劑為使一種液相之液滴於另一液相中之懸浮液穩定之物質。在無乳化劑之情況下，兩種液體會分離成兩個不混溶的液相。最常用的乳化劑摻合物含有具有12個或12個以上環氧乙烷單元之烷基酚或脂族醇，及十二烷基苯磺酸之油溶性鈣鹽。範圍在大約8至大約18的親水親油平衡(「HLB」)值通常會提供良好穩定之乳液。乳液穩定性有時可藉由添加少量EO-PO嵌段共聚物界面活性劑來改進。An emulsifier is a substance that stabilizes a suspension of one liquid phase in another liquid phase. In the absence of an emulsifier, the two liquids separate into two immiscible liquid phases. The most commonly used emulsifier blends contain an alkyl phenol or an aliphatic alcohol having 12 or more ethylene oxide units, and an oil soluble calcium salt of dodecyl benzene sulfonic acid. A hydrophilic-lipophilic balance ("HLB") value ranging from about 8 to about 18 will generally provide a well-stabilized emulsion. Emulsion stability can sometimes be improved by the addition of a small amount of EO-PO block copolymer surfactant.

增溶劑為在濃度超過臨界微胞濃度時，在水中形成微胞之界面活性劑。接著，微胞能夠溶解(dissolve)或溶解(solubilize)微胞之疏水部分內之水不溶性物質。通常用於溶解作用之界面活性劑類型為非離子型、脫水山梨糖醇單油酸酯、脫水山梨糖醇單油酸酯乙氧化物及油酸甲酯。Solubilizers are surfactants that form micelles in water at concentrations above the critical cell concentration. The micelles are then capable of dissolving or solubilizing the water insoluble material in the hydrophobic portion of the micelle. The types of surfactants commonly used for dissolution are nonionic, sorbitan monooleate, sorbitan monooleate ethoxylate and methyl oleate.

界面活性劑有時單獨使用，或與其他添加劑，諸如作為佐劑之礦物油或植物油，一起使用於噴霧罐混合物，以改進殺蟲劑對目標之生物效能。用於生物增強之界面活性劑類型通常視殺蟲劑之性質及作用模式而定。然而，其等通常為非離子物，諸如：烷基乙氧化物；線性脂族醇乙氧化物；以及脂族胺乙氧化物。Surfactants are sometimes used alone or in combination with other additives, such as mineral or vegetable oils as adjuvants, to improve the bioavailability of the pesticide to the target. The type of surfactant used for bio-enhancement is generally dependent on the nature of the pesticide and the mode of action. However, they are typically nonionics such as: alkyl ethoxylates; linear aliphatic alcohol ethoxylates; and aliphatic amine ethoxylates.

農業調配物中的載劑或稀釋劑為添加至殺蟲劑中以得到所需強度產品之物質。載劑通常為具有較高吸收能力之物質，而稀釋劑通常為具有較低吸收能力之物質。載劑及稀釋劑係使用於塵劑、可濕性粉末、顆粒及水可分散顆粒之調配物。The carrier or diluent in the agricultural formulation is the substance added to the pesticide to give the desired strength product. The carrier is usually a material having a higher absorption capacity, and the diluent is usually a substance having a lower absorption capacity. Carriers and diluents are used in the formulation of dusts, wettable powders, granules and water-dispersible granules.

有機溶劑主要用於可乳化濃縮物、水包油乳液、懸乳劑、油分散液及超低體積調配物之調配物，及在較少程度上用於顆粒調配物。有時使用溶劑的混合物。第一主要群組之溶劑為脂族石蠟油，諸如煤油或精製石蠟。第二主要群組(且最常見)包含芳族溶劑，諸如二甲苯及較高分子量之C9及C10芳族溶劑之餾份。當將調配物乳化至水中時，氯化烴係使用作防止殺蟲劑結晶之共溶劑。醇類有時用作共溶劑以增強溶劑功效。其他溶劑可包括植物油、種子油及植物油與種子油之酯類。Organic solvents are mainly used in the formulation of emulsifiable concentrates, oil-in-water emulsions, suspoemulsions, oil dispersions and ultra-low volume formulations, and to a lesser extent for particle formulations. Sometimes a mixture of solvents is used. The solvent of the first major group is an aliphatic paraffinic oil such as kerosene or refined paraffin. The second major group (and most commonly) comprises an aromatic solvent such as xylene and a fraction of higher molecular weight C9 and C10 aromatic solvents. When the formulation is emulsified into water, the chlorinated hydrocarbon is used as a cosolvent to prevent crystallization of the pesticide. Alcohols are sometimes used as cosolvents to enhance solvent efficacy. Other solvents may include vegetable oils, seed oils, and esters of vegetable oils and seed oils.

增稠劑或膠凝劑主要用於懸浮濃縮物、油分散液、乳液及懸乳劑之調配物，以改變液體之流變學或流動性質及防止分散粒子或液滴分離及沈降。增稠劑、膠凝劑及抗沈降劑通常屬於兩種類別，亦即水不溶性微粒及水溶性聚合物。可使用黏土及二氧化矽來製造懸浮濃縮物及油分散液調配物。此等物質類型之實例包括但不限於，蒙脫石、膨潤土、矽酸鎂鋁及鎂鋁海泡石。配於水基的懸浮濃縮物之水溶性多醣類多年來已用作增稠-膠凝劑。最常用之多醣類型為種子及海藻之天然萃取物或纖維素之合成衍生物。此等類型物質之實例包括但不限於，瓜爾膠；刺槐豆膠；角叉菜膠；海藻酸鹽；甲基纖維素；羧甲基纖維素鈉(SCMC)；以及羥乙基纖維素(HEC)。其他類型的抗沈降劑係以改質澱粉、聚丙烯酸酯、聚乙烯醇及聚氧化乙烯為基礎。另一種良好的抗沈降劑為三仙膠。Thickeners or gelling agents are mainly used in suspension concentrates, oil dispersions, emulsions and suspoemulsion formulations to alter the rheology or flow properties of the liquid and to prevent separation and precipitation of dispersed particles or droplets. Thickeners, gelling agents and anti-settling agents generally fall into two categories, namely water-insoluble particles and water-soluble polymers. Clay and cerium oxide can be used to make suspension concentrates and oil dispersion formulations. Examples of such types of materials include, but are not limited to, montmorillonite, bentonite, magnesium aluminum silicate, and magnesium aluminum sepiolite. Water-soluble polysaccharides formulated with water-based suspension concentrates have been used as thickening-gelling agents for many years. The most commonly used polysaccharide types are natural extracts of seeds and seaweed or synthetic derivatives of cellulose. Examples of such materials include, but are not limited to, guar gum; locust bean gum; carrageenan; alginate; methylcellulose; sodium carboxymethylcellulose (SCMC); and hydroxyethylcellulose ( HEC). Other types of anti-settling agents are based on modified starch, polyacrylate, polyvinyl alcohol and polyethylene oxide. Another good anti-settling agent is Sanxianjiao.

微生物會導致調配產品之腐敗。因此，使用防腐劑來消除或降低其等之作用。該等試劑之實例包括但不限於：丙酸及其鈉鹽；山梨酸及其鈉或鉀鹽；苯甲酸及其鈉鹽；對羥基苯甲酸鈉鹽；對羥基苯甲酸甲酯；及1,2-苯并異噻唑啉-3-酮(BIT)。Microorganisms can lead to corruption in blended products. Therefore, preservatives are used to eliminate or reduce the effects of them. Examples of such agents include, but are not limited to, propionic acid and its sodium salt; sorbic acid and its sodium or potassium salt; benzoic acid and its sodium salt; sodium p-hydroxybenzoate; methylparaben; and 1,2 - Benzoisothiazolin-3-one (BIT).

界面活性劑之存在，經常造成水基調配物在製造及經由噴灑槽施用時在混合操作期間起泡。為了減少起泡之傾向，通常在製造階段期間或裝填至瓶中之前添加消泡劑。通常存在有兩種類型的消泡劑，亦即聚矽氧以及非聚矽氧。聚矽氧通常為二甲基聚矽氧烷之水性乳液，而非聚矽氧消泡劑為水不溶性油，諸如辛醇及壬醇，或二氧化矽。在該兩種情況下，消泡劑之功能為自空氣-水界面中替換界面活性劑。The presence of a surfactant often causes the water-based formulation to foam during the mixing operation when it is manufactured and applied via a spray tank. To reduce the tendency to foam, defoamers are typically added during the manufacturing stage or prior to filling into the bottle. There are generally two types of defoamers, namely polyoxynium and non-polyoxygen. The polyoxyxylene is typically an aqueous emulsion of dimethyl polyoxane, while the non-polyoxygen defoamer is a water insoluble oil such as octanol and decyl alcohol, or cerium oxide. In both cases, the function of the antifoaming agent is to replace the surfactant from the air-water interface.

「綠色」製劑(例如佐劑、界面活性劑、溶劑)可降低作物保護調配物之整體環境足跡。綠色試劑為生物可降解的，且通常衍生自天然及/或永續來源，例如植物及動物來源。特定實例為：植物油、種子油及其酯類，以及烷氧基化烷基聚葡糖苷。施用 "Green" preparations (eg, adjuvants, surfactants, solvents) can reduce the overall environmental footprint of crop protection formulations. Green reagents are biodegradable and are typically derived from natural and/or sustainable sources, such as plant and animal sources. Specific examples are: vegetable oils, seed oils and their esters, and alkoxylated alkyl polyglucosides. Application

式1的分子可施用於任何所在地。施用此等分子之特定的所在地包括紫花苜蓿、杏仁、蘋果、大麥、豆類、油菜、玉米、棉花、十字花科植物、花、飼料物種(黑麥草(Rye Grass)、蘇丹草(Sudan Grass)、高牛毛草(Tall Fescue)、肯塔基藍草(Kentucky Blue Grass)及三葉草(Clover))、水果、萵苣、燕麥、油籽作物、橘子、花生、梨、胡椒、馬鈴薯、水稻、高粱、大豆、草莓、甘蔗、甜菜、向日葵、煙草、蕃茄、小麥(舉例而言，硬紅冬麥(Hard Red Winter Wheat)、軟紅冬麥(Soft Red Winter Wheat)、白冬小麥(White Winter Wheat)、硬紅春麥(Hard Red Spring Wheat)及杜蘭春小麥(Durum Spring Wheat))，和其他有價值的作物生長之所在地或其種子待種植之處。The molecule of Formula 1 can be applied to any location. Specific locations for the application of such molecules include alfalfa, almonds, apples, barley, beans, canola, corn, cotton, cruciferous plants, flowers, feed species (Rye Grass, Sudan Grass, Tall Fescue, Kentucky Blue Grass and Clover, Fruit, Lettuce, Oats, Oilseed Crops, Oranges, Peanuts, Pears, Peppers, Potatoes, Rice, Sorghum, Soy, Strawberries , sugar cane, sugar beet, sunflower, tobacco, tomato, wheat (for example, Hard Red Winter Wheat, Soft Red Winter Wheat, White Winter Wheat, Hard Red Spring Wheat) (Hard Red Spring Wheat) and Durum Spring Wheat, and where other valuable crops are grown or where their seeds are to be planted.

式1的分子亦可施用於植物，如作物生長之處，以及可造成此等植物的商業損失的害蟲水平低(甚至並無實際的存在)之區域。此所在地施用此等分子對於此所在地生長的植物為有利的。此等益處可以包括但不限於：協助植物生長出更好的根系；協助植物更佳地承受壓力生長條件；改進植物健康；改進植物產量(例如增加生物質及/或增加有價值成分之含量)；改進植物活力(例如改進植物生長及/或葉子更綠)；改進植物品質(例如改進某些成分之含量或組成)；以及改進植物對非生物及/或生物脅迫之耐受性。Molecules of Formula 1 can also be applied to plants, such as where the crop is grown, and areas where the level of pests that cause commercial loss of such plants is low (even without actual presence). The application of such molecules at this location is advantageous for plants grown in this location. Such benefits may include, but are not limited to, assisting plants in growing better root systems; assisting plants to better withstand stress growth conditions; improving plant health; improving plant yield (eg, increasing biomass and/or increasing the amount of valuable ingredients). Improving plant vigor (eg, improving plant growth and/or greener leaves); improving plant quality (eg, improving the content or composition of certain ingredients); and improving plant tolerance to abiotic and/or biotic stresses.

在栽種各種植物時，式1的化合物可以與硫酸銨一起施用，因這樣可以提供額外的益處。When planting various plants, the compound of Formula 1 can be administered with ammonium sulfate as this provides additional benefits.

式1分子可以施用於經基因改造以表現特殊性狀，諸如蘇力菌(Bacillus thuringiensis ) (舉例而言，Cry1Ab、Cry1Ac、Cry1Fa、Cry1A.105、Cry2Ab、Vip3A、mCry3A、Cry3Ab、Cry3Bb、Cry34Ab1/Cry35Ab1)，其他殺昆蟲性毒素，或該等表現除草劑耐受性之植物，或是該等具有表現殺昆蟲性毒素、除草劑耐受性、營養強化作用或其他任一有利性狀之「堆疊式」外來基因者之植物上、之中或周圍。Molecules of Formula 1 can be applied to genetically engineer to express specific traits, such as Bacillus thuringiensis (for example, Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1/Cry35Ab1) ), other insecticidal toxins, or such plants that exhibit herbicide tolerance, or "stacked" that exhibit insecticidal toxins, herbicide tolerance, nutritional fortification, or any other beneficial trait "On, in or around the plant of a foreign gene."

式1分子可施用至待控制害蟲之植物葉子及/或果實部分。此等分子會直接與害蟲接觸，或害蟲於食用植物或吸取汁液或植物其他營養素時，會攝入此等分子。Molecules of Formula 1 can be applied to the leaves and/or fruit portions of the plant to be controlled. These molecules will come into direct contact with the pests, or the pests will ingest these molecules when they consume the plants or extract juice or other nutrients from the plant.

式1分子亦可施用至土壤，且當以此方式施用時，可控制食用根與莖之害蟲。根可吸收此等分子藉此將其送至植物之葉子部分，以控制地面上部嚼食與汁液取食之害蟲。Molecules of Formula 1 can also be applied to the soil, and when applied in this manner, pests of edible roots and stems can be controlled. The roots can absorb these molecules and thereby deliver them to the leaf portion of the plant to control the pests that feed on the ground and chew.

可藉由在植物的不同部分施用(例如藉由噴灑一所在地)式1分子，利用殺蟲劑在植物中的系統性移動，而控制位於植物另一部分的害蟲。舉例而言，例如，可藉由滴灌或條施，藉由以例如種植前或種植後之土壤澆灌而處理土壤，或藉由種植前處理植物種子來達成控制食葉昆蟲。Pests located in another part of the plant can be controlled by applying a systemic movement of the insecticide in the plant by applying one molecule of the formula in a different part of the plant (for example by spraying a locus). For example, controlling leaf-feeding insects can be achieved by drip irrigation or strip application, by treating the soil with, for example, soiling before or after planting, or by treating the plant seeds before planting.

式1的分子可以與誘餌一起施用。一般而言，在誘餌情況下，將誘餌置於地面，白蟻可與誘餌接觸及/或被吸引。亦可將誘餌施用至建築表面(水平、垂直或傾斜表面)，該處螞蟻、白蟻、蟑螂與蒼蠅，皆會與誘餌接觸及/或被吸引。The molecule of Formula 1 can be administered with the bait. In general, in the case of bait, the bait is placed on the ground and termites can be in contact with and/or attracted to the bait. The bait can also be applied to the building surface (horizontal, vertical or sloping surface) where ants, termites, cockroaches and flies are in contact with and/or attracted to the bait.

式1分子可囊封在膠囊內、或置放於膠囊表面上。膠囊的大小可在奈米大小(直徑大約100-900奈米)至微米大小(直徑大約10-900微米)範圍內。The molecule of Formula 1 can be encapsulated within a capsule or placed on the surface of a capsule. Capsules can range in size from nanometer size (about 100-900 nm in diameter) to micron size (about 10-900 microns in diameter).

式1分子可以施用於害蟲之卵。由於一些害蟲之卵具有抗某些殺蟲劑之獨特能力，故可能需要重複施用此等分子以控制新出現之幼蟲。The molecule of formula 1 can be applied to the eggs of pests. Since some pest eggs have unique capabilities against certain insecticides, it may be necessary to repeatedly apply these molecules to control emerging larvae.

式1分子可以施用作為種子處理。可對將發芽之所有類型的種子進行種子處理，包括經遺傳修飾以表現特殊性狀之植物的種子。代表性實例包括對無脊椎動物害蟲，諸如蘇力菌(Bacillus thuringiensis )，表現蛋白毒性或其他殺昆蟲毒素者，表現除草劑耐受性者，諸如「Roundup Ready」種子，或具有表現殺昆蟲毒素、除草劑耐受性、營養增強、耐旱性或任何其他有益特性之「堆疊式」外來基因者。另外，此等使用式1分子之種子處理可進一步增強植物耐嚴苛生長條件的能力更佳。由此產生較健康，較有活力之植物，此在收穫時節可導致更高的產量。一般而言，預期每100,000個種子約1公克至約500公克之此等分子會提供良好的益處，預期每100,000個種子約10公克至約100公克之量會提供更佳的益處，且預期每100,000個種子約25公克至約75公克之量會提供甚至更佳的益處。Molecules of Formula 1 can be administered as a seed treatment. Seeds of all types of seeds that will germinate may be seeded, including seeds of plants that have been genetically modified to exhibit a particular trait. Representative examples include invertebrate pests, such as Bacillus thuringiensis , which exhibit protein toxicity or other insecticidal toxins, exhibit herbicide tolerance, such as "Roundup Ready" seeds, or have the performance of insecticidal toxins. A "stacked" foreign gene with herbicide tolerance, nutrient augmentation, drought tolerance or any other beneficial property. In addition, the use of seed treatment of the formula 1 molecule further enhances the ability of the plant to withstand harsh growth conditions. This results in a healthier, more vigorous plant that can result in higher yields during harvest. In general, it is expected that such molecules will provide good benefits from about 1 gram to about 500 grams per 100,000 seeds, and it is expected that an amount of from about 10 grams to about 100 grams per 100,000 seeds will provide better benefits, and it is expected that each An amount of from about 25 grams to about 75 grams of 100,000 seeds will provide even better benefits.

式1的分子可與土壤改良領域中的一或多種活性成分一起使用。The molecule of Formula 1 can be used with one or more active ingredients in the field of soil improvement.

式1分子可用於控制獸醫學領域或在非人類動物飼養領域中之內寄生蟲及外寄生蟲。此等分子可以舉例而言藉由，例如錠劑、膠囊、飲料、顆粒形式經口投與，藉由以例如浸泡、噴灑、傾倒、點藥及噴粉形式塗覆皮膚，以及藉由以例如注射劑形式的非經腸投與來施用。Molecules of Formula 1 can be used to control parasites and ectoparasites in the field of veterinary medicine or in the field of non-human animal feeding. Such molecules can be administered, for example, by oral administration, for example, in the form of tablets, capsules, beverages, granules, by coating the skin in, for example, soaking, spraying, pouring, dispensing, and dusting, and by, for example, Administration by parenteral administration in the form of an injection.

式1分子亦可有利地用於家畜飼養，例如牛、雞、鵝、山羊、豬、綿羊及火雞。其等亦可有利地用於寵物，諸如馬、犬及貓。欲控制之特定害蟲將為會對該等動物造成麻煩之蒼蠅、跳蚤及壁蝨。適合的調配物與飲用水或飼料一起經口投與該等動物。適合的劑量及調配物視物種而定。Molecules of Formula 1 can also be advantageously used in livestock breeding, such as cattle, chickens, geese, goats, pigs, sheep, and turkeys. They can also be advantageously used for pets such as horses, dogs and cats. The specific pests to be controlled will be flies, fleas and ticks that can cause trouble to these animals. Suitable formulations are administered orally with the drinking water or feed. Suitable dosages and formulations will depend on the species.

式1分子亦可用於控制寄生蟲，尤其是上列動物腸道中的寄生蟲。Molecules of Formula 1 can also be used to control parasites, particularly parasites in the gut of animals listed above.

式1分子亦可用於人類健康照護之治療方法。此等方法包括但不限於，以例如錠劑、膠囊、飲料、顆粒形式經口投與及藉由皮膚施用。Formula 1 molecules can also be used in the treatment of human health care. Such methods include, but are not limited to, oral administration in the form of, for example, lozenges, capsules, beverages, granules, and administration by the skin.

式1分子亦可施用於侵入性害蟲。全世界之害蟲正遷移至新環境(對於此害蟲而言)，且此後在該新環境中變成新的侵入物種。此等分子亦可用於該等新的侵入物種以在該新環境中對其進行控制。Molecules of Formula 1 can also be applied to invasive pests. Pests around the world are migrating to new environments (for this pest) and have since become new invasive species in this new environment. These molecules can also be used in these new invasive species to control them in this new environment.

在使用或商業販售殺蟲劑之前，此類殺蟲劑會依據各種政府法規(地方、地區、州、國家和國際)，進行漫長的評估過程。大量數據要求由監管機構指定，且必須由產品註冊者或代表產品註冊者之第三方，通常使用與全球資訊網連接之電腦，經由資料生成及提交來處理。之後，這些政府機關會檢視這些數據，若結論判定為安全，便會提供潛在使用者或販售者產品註冊核准證書。此後，在產品註冊通過與支持之地區，此使用者或販售者可使用或販售此殺蟲劑。Prior to the use or commercial sale of pesticides, such pesticides undergo a lengthy evaluation process in accordance with various government regulations (local, regional, state, national, and international). A large amount of data is required to be specified by the regulatory body and must be handled by the product registrant or a third party acting on behalf of the product registrar, typically using a computer connected to the World Wide Web, via data generation and submission. These government agencies then review the data and, if the conclusion is judged to be safe, provide a potential user or vendor product registration approval certificate. Thereafter, the user or vendor may use or sell the pesticide in areas where the product is registered and supported.

如式1之分子可經測試來決定其對抗害蟲之藥效。此外，式1之分子可與另一種活性成分混合以形成一種殺蟲組成物，然後使用習用的測試程序來測試該組成物，以判定其是否為協同性的。再者，可導入作用模式之研究，以決定該分子是否具有與其他殺蟲劑不同之作用模式。之後，此類收集之數據可經由如網際網路傳送至第三方。The molecule of Formula 1 can be tested to determine its efficacy against pests. Alternatively, the molecule of Formula 1 can be combined with another active ingredient to form a pesticidal composition which is then tested using conventional test procedures to determine if it is synergistic. Furthermore, studies of the mode of action can be introduced to determine if the molecule has a different mode of action than other pesticides. This collected data can then be transmitted to third parties via, for example, the Internet.

因此，根據上述以及表格部分的表格，提供下列額外的細節(D)。1D. 一種具下式之分子 式1 其中：(A)       Ar1 係選自於下列所構成的群組：呋喃基、苯基、嗒基、吡啶基、嘧啶基，或是噻吩基， 其中每個呋喃基、苯基、嗒基、吡啶基、嘧啶基，及噻吩基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 較佳地，Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 更佳地，Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、Cl、(C1 -C4 )鹵烷基及(C1 -C4 )鹵烷氧基，  還更佳地，Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、Cl、CF3 及OCF3 ；(B)       Het 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子，以及其中Ar1 與L1 互相不為鄰位，但可為間位或對位，例如就5員環而言，其等為1,3，且就6員環而言，其等為1,3或1,4， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 較佳地，Het 為(1b) (1b) ， 其中R6 可以選擇性地以選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 更佳地，Het 為(1b) (1b) ， 其中，R6 為H；(C)       L1 係選自於下列所構成的群組：(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基，以及(C2 -C6 )炔基， 其中每個烷基、鹵烷基、環烷基、烯基及炔基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基，以及(C2 -C6 )炔基， 較佳地，L1 係選自於下列所構成的群組 (1c) ， (1d) ，以及 (1e) ， 其中R7 、R8 、R9 及R10 係各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基，以及(C2 -C6 )炔基， 更佳地，L1 係選自於下列所構成的群組 (1c) ， (1d) ，以及 (1e) ， 其中，每個R7 、R8 、R9 及R10 係獨立地選自於H及(C1 -C4 )烷基所構成的群組， 還更佳地，L1 係選自於下列所構成的群組 (1c) ， (1d) ，以及 (1e) ， 其中，每個R7 、R8 、R9 及R10 係獨立地選自於H及CH3 所構成的群組；(D)       Ar2 係選自於下列所構成的群組：呋喃基、苯基、嗒基、吡啶基、嘧啶基，或是噻吩基， 其中每個呋喃基、苯基、嗒基、吡啶基、嘧啶基，及噻吩基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基； 較佳地，Ar2 為(1f) (1f) ， 其中：(1) X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 、 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 更佳地，Ar2 為(1f) (1f) ， 其中：(1) X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C1 -C4 )烷氧基，以及C(O)O-(C1 -C4 )烷基， 還更佳地，Ar2 為(1f) (1f) ， 其中：(1) X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、CH3 、CF3 、OCH3 ，以及C(O)O-CH3 ；(E) R15 係選自於下列所構成的群組：H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、C(O)-NRx Ry 、C(O)-苯基、(C1 -C4 )烷基-NRx Ry 、C(O)O-(C1 -C4 )烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基-OC(=O)O-(C1 -C4 )烷基， 其中每個烷基、環烷基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 較佳地，R15 為H；(F) Q1 係選自於O及S所構成的群組，較佳Q1 為O；(G)Q2 係選自於O及S所構成的群組，較佳Q2 為S；(H) R16 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基)、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)， 較佳地，R16 為(K) ；(I) R17 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)， 較佳地，R17 為(K) ；(J) L2 係選自於下列所構成的群組：(C3 -C8 )環烷基、苯基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、(C2 -C6 )烯基-O-苯基、(Het-1)、(C1 -C4 )烷基-(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)， 較佳地，L2 係選自於下列所構成的群組 (1g) 及 (1h) ， 其中R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)， 更佳地，L2 係選自於下列所構成的群組 (1g) 及 (1h) ， 其中R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基，以及(C1 -C4 )烷基-O-(C1 -C4 )烷基， 還更佳地，L2 係選自於下列所構成的群組 (1g) 及 (1h) ， 其中，R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、CH3 、CH2 CH2 CH3 、CH(CH3 )2 、CF3 、環丙基、OCH3 、OCH2 CH3 、OCH(CH3 )2 、OC(CH3 )3 、OCH(CH3 )CH2 CH3 、OCF3 、OCH2 CF3 、CH2 OCH3 ，及CH(CH3 )OCH3 ；(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起形成一個4-至7-員飽和或不飽和之烴基環(hydrocarbyl cyclic)基團，其可以進一步含有選自於氮、硫或氧所構成的群組之一個或更多個雜原子， 其中該烴基環基團可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：側氧、R18 及R19 ， 其中R18 及R19 係各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、側氧、硫酮基、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)， 較佳地，R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組 (1i) 及 (1j) ， 其中R18 及R19 係各自獨立地選自於下列所構成的群組：H 、F、Cl、Br、I、CN、NO2、側氧、硫酮基、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)， 更佳地，R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組 (1i) 及 (1j) ， 其中R18 及R19 各自為H，(L) Rx 及Ry 係各自獨立地選自於下列所構成的群組：H、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基，以及苯基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(M)      (Het-1) 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(N) n 每一者係獨立地為0、1或2；以及式1的分子之N-氧化物、農業上可接受的酸加成鹽類、鹽類衍生物、溶劑合物、結晶性多形體、同位素、解析的立體異構物，以及互變異構物。2D. 如1D 之分子，其中(A) Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、Cl、(C1 -C4 )鹵烷基及(C1 -C4 )鹵烷氧基；(B)       Het 為(1b) (1b) ， 其中，R6 為H；(C) L1 係選自於下列所構成的群組 (1c) ， (1d) ， 及 (1e) ， 其中，每個R7 、R8 、R9 及R10 係獨立地選自於H及(C1 -C4 )烷基所構成的群組；(D)       Ar2 為(1f) (1f) ， 其中：(1)X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C1 -C4 )烷氧基，以及C(O)O-(C1 -C4 )烷基；(E)R15 為H；(F) Q1 為O；(G)Q2 為S；(H)R16 為(K) ；(I)R17 為(K) ；(J) L2 係選自於下列所構成的群組 (1g) 及 (1h) ， 其中R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基，及(C1 -C4 )烷基-O-(C1 -C4 )烷基；以及(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組 (1i) 及 (1j) ， 其中R18 及R19 各自為H。3D. 如1D或2D之分子，其中(A) Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、Cl、CF3 及OCF3 ；(B)       Het 為(1b) (1b) ， 其中，R6 為H；(C) L1 係選自於下列所構成的群組 (1c) ， (1d) ， 及 (1e) ， 其中，每個R7 、R8 、R9 及R10 係獨立地選自於H及CH3 所構成的群組；(D)       Ar2 為(1f) (1f) ， 其中：(1) X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、CH3 、CF3 、OCH3 ，以及C(O)O-CH3 ；(E)R15 為H；(F) Q1 為O；(G)Q2 為S；(H)R16 為(K) ；(I)R17 為(K) ；(J) L2 係選自於下列所構成的群組： (1g) 及 (1h) ， 其中，R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、CH3 、CH2 CH2 CH3 、CH(CH3 )2 、CF3 、環丙基、OCH3 、OCH2 CH3 、OCH(CH3 )2 、OC(CH3 )3 、OCH(CH3 )CH2 CH3 、OCF3 、OCH2 CF3 、CH2 OCH3 ，及CH(CH3 )OCH3 ；以及(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組 (1i) 及 (1j) ， 其中R18 及R19 各自為H。4D. 如1D、2D或3D中任一者之分子，其中該分子為 5D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含一活性成分。6D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含選自於下列之一種活性成分：殺蜱蟎劑、除藻劑、拒食劑、殺鳥劑(avicide)、殺菌劑、驅鳥劑、化學絕育劑、殺真菌劑、除草劑安全劑、除草劑、誘蟲劑、驅蟲劑、殺昆蟲劑、驅哺乳動物劑、交配干擾劑、殺蟎劑、殺線蟲劑、植物活化劑、植物生長調節劑、滅鼠劑、協力劑，以及殺病毒劑。7D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含選自於AIGA 之活性成分。8D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含AI–1 。9D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含AI–2 。10D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含羅提蘭 (Lotilaner) 。11D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含選自於表 A 之分子。12D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含選自於AIGA–2 之活性成分。13D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含陶斯松(chlorpyrifos)。14D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含六伏隆(hexaflumuron)。15D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含滅芬諾(methoxyfenozide)。16D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含多氟脲(noviflumuron)。17D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含賜諾特(spinetoram)。18D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含賜諾殺(spinosad)。19D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含氟啶蟲胺腈(sulfoxaflor)。20D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含選自於AIGA–2 之活性成分。21D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含亞醌蟎(acequinocyl)。22D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含亞滅培(acetamiprid)。23D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含乙醯蟲腈(acetoprole)。24D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含阿維菌素(avermectin)。25D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含谷速松(azinphos-methyl)。26D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含必芬蟎(bifenazate)。27D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含畢芬寧(bifenthrin)。28D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含胺甲(carbaryl)。29D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含加保扶(carbofuran)。30D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含克凡派(chlorfenapyr)。31D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含克福隆(chlorfluazuron)。32D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含可芬諾(chromafenozide)。33D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含可尼丁(clothianidin)。34D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含賽扶寧(cyfluthrin)。35D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含賽滅寧(cypermethrin)。36D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含第滅寧(deltamethrin)。37D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含汰芬隆(diafenthiuron)。38D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含因滅汀苯甲酸鹽(emamectin benzoate)。39D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含安殺番(endosulfan)。40D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含益化利(esfenvalerate)。41D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含乙蟲腈(ethiprole)。42D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含依殺蟎(etoxazole)。43D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含芬普尼(fipronil)。44D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含氟尼胺(flonicamid)。45D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含嘧蟎酯(fluacrypyrim)。46D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含γ-賽洛寧(gamma -cyhalothrin)。47D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含合芬隆(halofenozide)。48D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含因得克(indoxacarb)。49D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含λ-賽洛寧(lambda -cyhalothrin)。50D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含祿芬隆(lufenuron)。51D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含馬拉松(malathion)。52D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含納乃得(methomyl)。53D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含諾伐隆(novaluron)。54D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含百滅寧(permethrin)。55D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含啶蟲丙醚(pyridalyl)。56D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含畢汰芬(pyrimidifen)。57D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含賜派芬(spirodiclofen)。58D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含得芬諾(tebufenozide)。59D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含賽果培(thiacloprid)。60D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含賽速安(thiamethoxam)。61D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含硫敵克(thiodicarb)。62D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含脫芬瑞(tolfenpyrad)。63D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含ζ-賽滅寧。64D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含一生物性殺昆蟲劑。65D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自乙醯膽鹼酯酶(AChE) 抑制劑 之活性成分。66D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自乙醯膽鹼酯酶(AChE) 抑制劑 之活性成分。67D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自GABA- 閘控型氯離子通道拮抗劑 之活性成分。68D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自鈉離子通道調節劑 之活性成分。69D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自菸 鹼型乙醯膽鹼(nAChR) 協同劑 之活性成分。70D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自菸 鹼型乙醯膽鹼受器(nAChR) 別構活化物 之活性成分。71D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自氯離子通道活化劑 之活性成分。72D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自保幼激素模擬物 之活性成分。73D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自雜類非特異性( 多重位置) 抑制劑 之活性成分。74D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自弦音器官 (Chordotonal Organs ) 調節劑 之活性成分。75D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自蟎生長抑制劑 之活性成分。76D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自破壞昆蟲中腸膜之微生物 之活性成分。77D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自粒腺體ATP 合成酶抑制劑 之活性成分。78D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自經由破壞質子梯度之氧化性磷酸化非耦聯劑 之活性成分。79D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自菸 鹼型乙醯膽鹼受器(nAChR) 通道阻斷劑 之活性成分。80D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自幾丁質生合成抑制劑，第0 型 ，之活性成分。81D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自幾丁質生合成抑制劑，第1 型 ，之活性成分。82D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自雙翅目脫皮干擾劑 之活性成分。83D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自蛻皮激素受器協同劑 之活性成分。84D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自章魚胺受器協同劑 之活性成分。85D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自粒腺體複合物III 電子傳遞抑制劑 之活性成分。86D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自粒腺體複合物I 電子傳遞抑制劑 之活性成分。87D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自電壓- 依賴型鈉離子通道阻斷劑 之活性成分。88D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自乙醯基輔酶A 羧化酶抑制劑 之活性成分。89D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自粒腺體複合物IV 電子傳遞抑制劑 之活性成分。90D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自粒腺體複合物II 電子傳遞抑制劑 之活性成分。91D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自羅納丹受 器 (R yanodine receptor) 調節劑 之活性成分。92D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子，其進一步包含來自UN 組 之活性成分。93D. 如5D至且含括92D中任一者之殺蟲組成物，其中如式1分子比活性成分之重量比為100:1至1:100。94D. 如5D至且含括92D中任一者之殺蟲組成物，其中如式1分子比活性成分之重量比為50:1至1:50。95D. 如5D至且含括92D中任一者之殺蟲組成物，其中如式1分子比活性成分之重量比為20:1至1比20。96D. 如5D至且含括92D中任一者之殺蟲組成物，其中如式1分子比活性成分之重量比為10:1至1:10。97D. 如5D至且含括92D中任一者之殺蟲組成物，其中如式1分子比活性成分之重量比為5:1至1:5。98D. 如5D至且含括92D中任一者之殺蟲組成物，其中如式1分子比活性成分之重量比為3:1至1:3。99D. 如5D至且含括92D中任一者之殺蟲組成物，其中如式1分子比活性成分之重量比為2:1至1:2。100D. 如5D至且含括92D中任一者之殺蟲組成物，其中如式1分子比活性成分之重量比為1:1。101D. 如5D至且含括92D中任一者之殺蟲組成物，其中式1分子比活性成分之重量比為X:Y ；其中X 為式1之分子的重量份且Y 為活性成分之重量份；進一步地其中X 重量份之數值範圍為0 ＜X ≤ 100且Y 重量份之數值範圍為0 ＜Y ≤ 100；以及進一步地其中X 及Y 係選自於表C。102D. 如101D之殺蟲組成物，其中式1分子比活性成分之重量比範圍為X1 ：Y1 至X2 ：Y2 ；進一步地其中X1 ＞Y1 且X2 ＜Y2 。103D. 如101D之殺蟲組成物，其中式1分子比活性成分之重量比範圍為X1 ：Y1 至X2 ：Y2 ；進一步地其中X1 ＞Y1 且X2 ＞Y2 。104D. 如101D之殺蟲組成物，其中式1分子比活性成分之重量比範圍為X1 ：Y1 至X2 ：Y2 ；進一步地其中X1 ＜Y1 且X2 ＜Y2 。105D .  如5D至且含括104D中任一者之殺蟲組成物，其中該殺蟲組成物進一步包含硫酸銨。106D. 如5D至且含括105D中任一者之殺蟲組成物，其中該殺蟲組成物為協同性的。107D. 一種生產殺蟲組成物之方法，該方法包含混合如請求項1D、2D、3D或4D中任一項之分子與一或多種活性成分。108D. 一種測試如107D之殺蟲組成物之方法，以判定其是否為協同性的。109D. 一種殺蟲組成物，其包含如1D、2D、3D或4D中任一者之分子及種子。110D. 一種如1D、2D、3D或4D中任一者之分子，其中該分子係農業上可接受的酸加成鹽類的形式。111D. 一種如1D、2D、3D或4D中任一者之分子，其中該分子係鹽類衍生物的形式。112D. 一種如1D、2D、3D或4D中任一者之分子，其中該分子係溶劑合物的形式。113D. 一種如1D、2D、3D或4D中任一者之分子，其中該分子係酯類衍生物的形式。114D. 一種如1D、2D、3D或4D中任一者之分子，其中該分子係結晶性多形體的形式。115D. 一種如1D、2D、3D或4D中任一者之分子，其中該分子具有氘、氚、放射性碳或是其等之組合。116D. 一種如1D、2D、3D或4D中任一者之分子，其中該分子係一個或更多個立體異構物的形式。117D. 一種如1D、2D、3D或4D中任一者之分子，其中該分子係解析的立體異構物的形式。118D. 一種控制害蟲的方法，該方法包含施用殺蟲有效量的如1D、2D、3D或4D中任一者之分子至一所在地。119D. 一種控制害蟲的方法，該方法包含施用殺蟲有效量的如5D至且含括106D中任一者之殺蟲組成物至一所在地。120D. 如118D或119D之方法，其中該害蟲係選自於螞蟻、蚜蟲、床虱(bed bug)、甲蟲、蠹蟲(bristletails)、毛蟲、蟑螂、蟋蟀、蠼螋(earwigs)、跳蚤、蒼蠅、蚱蜢、螬、葉蟬、蝨、蝗蟲、蛆、蟎、線蟲(nematode)、飛蝨(planthopper)、木蝨(psyllids)、鋸蜂(sawflies)、介殼蟲、蠹魚(silverfish)、蛞蝓、蝸牛、蜘蛛、彈尾蟲、臭蟲、綜合綱(symphylans)、白蟻、薊馬(thrips)、壁蝨、胡蜂、粉虱，以及線蟲(wireworm)。121D. 如118D或119D之方法，其中該害蟲係選自於螯肢動物亞門(Subphyla Chelicerata) 、多足亞門(Myriapoda) ，或六足亞門(Hexapoda) 。122D. 如118D或119D之方法，其中該害蟲係選自於蛛形綱 (Arachnida) 、綜合綱 (Symphyla) ， 或 昆蟲綱 (Insecta) 。 123D. 如118D或119D之方法，其中該害蟲係選自於虱目 (Order Anoplura) 。124D. 如118D或119D之方法，其中該害蟲係選自於鞘翅目 (Order Coleoptera) 。125D. 如118D或119D之方法，其中該害蟲係選自於革翅目 (Order Dermaptera) 。126D. 如118D或119D之方法，其中該害蟲係選自於蜚蠊目 (Order Blattaria) 。127D. 如118D或119D之方法，其中該害蟲係選自於雙翅目 (Order Diptera) 。128D. 如118D或119D之方法，其中該害蟲係選自於半翅目 (Order Hemiptera) 。129D. 如118D或119D之方法，其中該害蟲係選自於膜翅目 (Order Hymenoptera) 。130D. 如118D或119D之方法，其中該害蟲係選自於等翅目 (Order Isoptera) 。131D. 如118D或119D之方法，其中該害蟲係選自於鱗翅目 (Order Lepidoptera) 。132D. 如118D或119D之方法，其中該害蟲係選自於食毛目 (Order Mallophaga) 。133D. 如118D或119D之方法，其中該害蟲係選自於直翅目 (Order Orthoptera) 。134D. 如118D或119D之方法，其中該害蟲係選自於囓蟲目 ( Order Psocoptera ) 。135D. 如118D或119D之方法，其中該害蟲係選自於蚤目 (Order Siphonaptera) 。136D. 如118D或119D之方法，其中該害蟲係選自於纓翅目 (Order Thysanoptera) 。137D. 如118D或119D之方法，其中該害蟲係選自於纓尾目 (Order Thysanura) 。138D. 如118D或119D之方法，其中該害蟲係選自於蜱蟎目 (Order Acarina) 。139D. 如118D或119D之方法，其中該害蟲係選自於真蜘蛛目 (Order Araneae ) 。140D. 如118D或119D之方法，其中該害蟲係選自於結閥綱 (Class Symphyla ) 。141D. 如118D或119D之方法，其中該害蟲係選自於粘管亞綱 (Subclass Collembola ) 。142D. 如118D或119D之方法，其中該害蟲係選自於圓形動物門 (Phylum Nematoda) 。143D. 如118D或119D之方法，其中該害蟲係選自於軟體動物門 ( Phylum Mollusca ) 。144D. 如118D或119D之方法，其中該害蟲係取食汁液之害蟲。145D. 如144D之方法，其中該害蟲係選自於蚜蟲、葉蟬、蛾、介殼蟲(scales)、薊馬(thrips)、木蝨(psyllids)、水蠟蟲(mealybugs)、臭蟲，以及粉虱。146D. 如144D之方法，其中該害蟲係選自於虱目(Order Anoplura)及半翅目(Order Hemiptera)。147D. 如144D之方法，其中該害蟲係選自於輪盾介殼蟲屬(Aulacaspis spp.)、沫蟬屬(Aphrophora spp.)、蚜蟲屬(Aphis spp.)、粉虱屬(Bemisia spp.)、介殼蟲屬(Coccus spp.)、美洲蝽屬(Euschistus spp.)、草盲蝽屬(Lygus spp.)、長管蚜屬(Macrosiphum spp.)、稻綠蝽屬(Nezara spp.)，以及縊管蚜屬(Rhopalosiphum spp.)。148D. 如118D或119D之方法，其中該害蟲係嚼食性害蟲。149D. 如148D之方法，其中該害蟲係選自於毛蟲、甲蟲、蚱蜢及蝗蟲。150D. 如148D之方法，其中該害蟲係選自於鞘翅目(Coleoptera)及鱗翅目(Lepidoptera)。151D. 如148D之方法，其中該害蟲係選自於豆象屬(Acanthoscelides spp.)、豆葉甲蟲屬(Cerotoma spp.)、跳甲屬(Chaetocnema spp.)、肖葉甲蟲屬(Colaspis spp.)、圓頭犀金龜屬(Cyclocephala spp.)、葉甲屬(Diabrotica spp.)、葉象屬(Hypera spp.)、鰓角金龜屬(Phyllophaga spp.)、菜葉蚤屬(Phyllotreta spp.)、禾象鼻蟲屬(Sphenophorus spp.)、米象屬(Sitophilus spp.)。152D. 如118D或119D之方法，其中該所在地係紫花苜蓿、杏仁、蘋果、大麥、豆類、油菜、玉米、棉花、十字花科植物、萵苣、燕麥、橘子、花生、梨、胡椒、馬鈴薯、水稻、高粱、大豆、草莓、甘蔗、甜菜、向日葵、煙草、蕃茄、小麥，和其他有價值的作物生長或其種子種植之處。153D. 如118D或119D之方法，其中該所在地係經遺傳修飾以表現特殊性狀之植物種植之處。154D. 如118D或119D之方法，其中該施用係於植物葉子及/或果實部分上實行。155D. 如118D或119D之方法，其中該施用係於土壤實行。156D. 如118D或119D之方法，其中該施用係藉由滴灌、條施，或是種植前或種植後之土壤澆灌來實行。157D. 如118D或119D之方法，其中該施用係於植物葉子及/或果實部分實行，或是藉由種植前處理植物種子來實行。158D. 一種方法，其包含施用如1D、2D、3D或4D中任一者之分子至種子。159D. 一種方法，其包含施用如1D、2D、3D或4D之分子至一所在地，該所在地包括非人類動物飼養領域，以控制寄生蟲、外寄生蟲及二者。Therefore, the following additional details (D) are provided in accordance with the above table and the table of the table section.1D. a molecule with the following formula Formula 1 among them:(A) Ar 1 Is selected from the group consisting of furanyl, phenyl, hydrazinea pyridyl group, a pyrimidinyl group, or a thienyl group, wherein each furanyl group, phenyl group, hydrazine groupThe base, pyridyl, pyrimidinyl, and thienyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group, alkenyl group, alkynyl group, phenyl group, and phenoxy substituent It may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, preferably,Ar 1 for(1a) (1a) , among them:(1) X 1 Is selected from N and CR 1 The group formed, and(2) R 1 ,R 2 , R 3 , R 4 andR 5 Each is independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group, alkenyl group, alkynyl group, phenyl group, and phenoxy group can be selected. Sexually substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, more preferably,Ar 1 for(1a) (1a) , among them:(1) X 1 Is selected from N and CR 1 The group formed, and(2) R 1 ,R 2 , R 3 , R 4 andR 5 Each is independently selected from the group consisting of: H, Cl, (C1 -C4 Haloalkyl and (C1 -C4 a haloalkoxy group, still more preferably,Ar 1 for(1a) (1a) , among them:(1) X 1 Is selected from N and CR 1 The group formed, and(2) R 1 ,R 2 , R 3 , R 4 andR 5 Each is independently selected from the group consisting of: H, Cl, CF3 And OCF3 ;(B) Het a 5 or 6 membered, saturated or unsaturated heterocyclic ring containing one or more heteroatoms independently selected from nitrogen, sulfur or oxygen, and whereinAr 1 versusL 1 They are not adjacent to each other, but may be meta or para. For example, for a 5-member ring, it is 1, 3, and for a 6-member ring, it is 1, 3 or 1, 4, where Each heterocyclic ring may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO.2 Side oxygen, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group, alkenyl group, alkynyl group, phenyl group, and phenoxy substituent It may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, preferably,Het for(1b) (1b) , among themR 6 It may be optionally substituted with a substituent selected from the group consisting of H, F, Cl, Br, I, CN, NO.2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group, alkenyl group, alkynyl group, phenyl group, and phenoxy group can be selected. Sexually substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, more preferably,Het for(1b) (1b) , among them,R 6 Is H;(C) L 1 Is selected from the following group: (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C2 -C6 Alkenyl, and (C2 -C6 Alkynyl, wherein each alkyl, haloalkyl, cycloalkyl, alkenyl and alkynyl group may be optionally substituted with one or more substituents independently selected from the group consisting of: H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, and (C2 -C6 Alkynyl group, preferably,L 1 Is selected from the group consisting of the following (1c) , (1d) ,as well as (1e) , among themR 7 ,R 8 , R 9 andR 10 Each is independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, and (C2 -C6 Alkynyl group, more preferably,L 1 Is selected from the group consisting of the following (1c) , (1d) ,as well as (1e) , where eachR 7 ,R 8 , R 9 andR 10 Is independently selected from H and (C1 -C4 a group of alkyl groups, and even more preferably,L 1 Is selected from the group consisting of the following (1c) , (1d) ,as well as (1e) , where eachR 7 ,R 8 , R 9 andR 10 Lines are independently selected from H and CH3 The group formed;(D) Ar 2 Is selected from the group consisting of furanyl, phenyl, hydrazinea pyridyl group, a pyrimidinyl group, or a thienyl group, wherein each furanyl group, phenyl group, hydrazine groupThe base, pyridyl, pyrimidinyl, and thienyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group, alkenyl group, alkynyl group, phenyl group, and phenoxy substituent It may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(=O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group; preferably,Ar 2 for(1f) (1f) , among them:(1) X 2 Is selected from N and CR 13 The group formed, and(2) R 11 ,R 12 , R 13 , andR 14 Each is independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group, alkenyl group, alkynyl group, phenyl group, and phenoxy group can be selected. Sexually substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(=O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, more preferably,Ar 2 for(1f) (1f) , among them:(1) X 2 Is selected from N and CR 13 The group formed, and(2) R 11 ,R 12 , R 13 andR 14 Each is independently selected from the group consisting of: H, F, Cl, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C1 -C4 Alkoxy, and C(O)O-(C1 -C4 Alkyne, still better,Ar 2 for(1f) (1f) , among them:(1) X 2 Is selected from N and CR 13 The group formed, and(2) R 11 ,R 12 , R 13 andR 14 Each is independently selected from the group consisting of H, F, Cl, CH3 , CF3 OCH3 And C(O)O-CH3 ;(E) R 15 Is selected from the group consisting of: H, (C1 -C4 )alkyl, (C3 -C8 )cycloalkyl, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, C(O)-NRx Ry , C(O)-phenyl, (C1 -C4 alkyl-NRx Ry , C(O)O-(C1 -C4 )alkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(=O)O-(C1 -C4 An alkyl group, wherein each alkyl group, cycloalkyl group, alkenyl group, alkynyl group, and phenyl group are optionally substituted with one or more substituents independently selected from the group consisting of: H, F, Cl, Br, I, CN, NO2 Side oxygen, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(=O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, preferably,R 15 Is H;(F) Q 1 Is selected from the group consisting of O and S, preferablyQ 1 Is O;(G)Q 2 Is selected from the group consisting of O and S, preferablyQ 2 Is S;(H) R 16 It is selected from the following group:(K) , H, (C1 -C4 )alkyl, (C3 -C8 )cycloalkyl, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, C(O)-(C1 -C4 )alkyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, (C1 -C4 )alkylphenyl, (C1 -C4 )alkyl-O-phenyl, C(O)-(Het-1), Het-1, (C1 -C4 )alkyl-(Het-1), (C1 -C4 )alkyl-OC(O)-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)-NRx Ry (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 )alkyl-(Het-1), (C1 -C4 )alkyl-C(O)-(Het-1), (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 )alkyl (NRx Ry )-C(O)OH, (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 alkyl-NRx Ry (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 )alkyl-N(Rx )-C(O)O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 )alkyl (N(R)x )-C(O)O-(C1 -C4 )alkyl)-C(O)OH, (C1 -C4 )alkyl-C(O)-(Het-1)-C(O)O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)-(C3 -C8 )cycloalkyl, (C1 -C4 )alkyl-OC(O)-(Het-1), (C1 -C4 )alkyl-OC(O)-(C1 -C4 )alkyl-N(Rx )-C(O)O-(C1 -C4 )alkyl, (C1 -C4 alkyl-NRx Ry (C1 -C4 )alkyl-S(O)n -(Het-1), and (C1 -C4 An alkyl-O-(Het-1) wherein each alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, and (Het-1) can be optionally independently selected in one or more Substituted by the substituents of the following group: H, F, Cl, Br, I, CN, NO2 NRx Ry (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(=O)n -(C1 -C4 )alkyl, S(=O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)OH, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 )alkyl), phenyl, phenoxy, Si ((C1 -C4 )alkyl)3 , S(=O)n -NRx Ry And (Het-1), preferably,R 16 for(K) ;(I) R 17 It is selected from the following group:(K) , H, (C1 -C4 )alkyl, (C3 -C8 )cycloalkyl, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, C(O)-(C1 -C4 )alkyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, (C1 -C4 )alkylphenyl, (C1 -C4 )alkyl-O-phenyl, C(O)-(Het-1), Het-1, (C1 -C4 )alkyl-(Het-1), (C1 -C4 )alkyl-OC(O)-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)-NRx Ry (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 )alkyl-(Het-1), (C1 -C4 )alkyl-C(O)-(Het-1), (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 )alkyl (NRx Ry )-C(O)OH, (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 alkyl-NRx Ry (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 )alkyl-N(Rx )-C(O)O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-C(O)-N(Rx ) (C1 -C4 )alkyl (N(R)x )-C(O)O-(C1 -C4 )alkyl)-C(O)OH, (C1 -C4 )alkyl-C(O)-(Het-1)-C(O)O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)-(C1 -C4 )alkyl, (C1 -C4 )alkyl-OC(O)-(C3 -C8 )cycloalkyl, (C1 -C4 )alkyl-OC(O)-(Het-1), (C1 -C4 )alkyl-OC(O)-(C1 -C4 )alkyl-N(Rx )-C(O)O-(C1 -C4 )alkyl, (C1 -C4 alkyl-NRx Ry (C1 -C4 )alkyl-S(O)n -(Het-1), and (C1 -C4 An alkyl-O-(Het-1) wherein each alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, and (Het-1) can be optionally independently selected in one or more Substituted by the substituents of the following group: H, F, Cl, Br, I, CN, NO2 NRx Ry (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(=O)n -(C1 -C4 )alkyl, S(=O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)OH, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 )alkyl, phenyl, phenoxy, Si ((C1 -C4 )alkyl)3 , S(=O)n -NRx Ry And (Het-1), preferably,R 17 for(K) ;(J) L 2 Is selected from the following group: (C3 -C8 Cycloalkyl, phenyl, (C1 -C4 )alkylphenyl, (C1 -C4 )alkyl-O-phenyl, (C2 -C6 Alkenyl-O-phenyl, (Het-1), (C1 -C4 )alkyl-(Het-1), and (C1 -C4 An alkyl-O-(Het-1) wherein each alkyl, cycloalkyl, alkenyl, phenyl, and (Het-1) may be optionally selected from one or more independently selected from the group consisting of The substituents of the group formed are substituted: H, F, Cl, Br, I, CN, NO2 NRx Ry (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C1 -C4 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, O-(C)1 -C4 )alkyl, S-(C1 -C4 )alkyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, a phenoxy group, and (Het-1), wherein each alkyl group, cycloalkyl group, alkenyl group, phenyl group, and (Het-1) substituent may be optionally one or more Substituting a plurality of substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 NRx Ry (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C1 -C4 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, O-(C)1 -C4 )alkyl, S-(C1 -C4 )alkyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, a phenoxy group, and (Het-1), preferably,L 2 Is selected from the group consisting of the following (1g) and (1h) , among themR 20 ,R 21 , R 22 , R 23 andR 24 Each is independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 NRx Ry (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C1 -C4 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, O-(C)1 -C4 )alkyl, S-(C1 -C4 )alkyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, a phenoxy group, and (Het-1), wherein each alkyl group, cycloalkyl group, alkenyl group, phenyl group, and (Het-1) substituent may be optionally one or more Substituting a plurality of substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 NRx Ry (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C1 -C4 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, O-(C)1 -C4 )alkyl, S-(C1 -C4 )alkyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, a phenoxy group, and (Het-1), more preferably,L 2 Is selected from the group consisting of the following (1g) and (1h) , among themR 20 ,R 21 , R 22 , R 23 andR 24 Each is independently selected from the group consisting of: H, F, Cl, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Halon alkoxy, and (C1 -C4 )alkyl-O-(C1 -C4 Alkyne, still better,L 2 Is selected from the group consisting of the following (1g) and (1h) , among them,R 20 ,R 21 , R 22 , R 23 andR 24 Each is independently selected from the group consisting of H, F, Cl, CH3 , CH2 CH2 CH3 , CH (CH3 )2 , CF3 , cyclopropyl, OCH3 OCH2 CH3 , OCH (CH3 )2 , OC (CH3 )3 , OCH (CH3 )CH2 CH3 OCF3 OCH2 CF3 , CH2 OCH3 , and CH (CH3 )OCH3 ;(K) R 16 andR 17 versusC x (Q 2 )(N x ) Forming together a 4- to 7-membered saturated or unsaturated hydrocarbyl cyclic group, which may further comprise one or more heteroatoms selected from the group consisting of nitrogen, sulfur or oxygen, wherein The hydrocarbyl ring group may be optionally substituted with one or more substituents independently selected from the group consisting of: side oxygen,R 18 andR 19 , among themR 18 andR 19 Each is independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 Side oxygen, thioketone, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and (Het-1), preferably,R 16 andR 17 versusC x (Q 2 )(N x ) Together, it is selected from the group consisting of (1i) and (1j) , among themR 18 andR 19 Each is independently selected from the group consisting of:H , F, Cl, Br, I, CN, NO2, side oxygen, thioketone, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and (Het-1), more preferably,R 16 andR 17 versusC x (Q 2 )(N x ) Together, it is selected from the group consisting of (1i) and (1j) , among themR 18 andR 19 Each is H,(L) R x andR y Each is independently selected from the group consisting of: H, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, and a phenyl group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group, alkenyl group, alkynyl group, and phenyl group may be optionally one or more Substituted independently from the substituents of the following group: H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)H, C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and (Het-1);(M) (Het-1) a 5 or 6 membered, saturated or unsaturated heterocyclic ring containing one or more heteroatoms independently selected from nitrogen, sulfur or oxygen, wherein each heterocyclic ring may optionally be independently or in one or more Substituents selected from the group consisting of H, F, Cl, Br, I, CN, NO2 Side oxygen, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group, alkenyl group, alkynyl group, phenyl group, and phenoxy substituent It may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2 (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, (C2 -C6 Alkenyl, (C2 -C6 Alkynyl, S(O)n -(C1 -C4 )alkyl, S(O)n -(C1 -C4 Haloalkyl, OSO2 -(C1 -C4 )alkyl, OSO2 -(C1 -C4 Haloalkyl, C(O)-NRx Ry (C1 -C4 alkyl-NRx Ry , C(O)-(C1 -C4 )alkyl, C(O)O-(C1 -C4 )alkyl, C(O)-(C1 -C4 Haloalkyl, C(O)O-(C1 -C4 Haloalkyl, C(O)-(C3 -C8 )cycloalkyl, C(O)O-(C3 -C8 )cycloalkyl, C(O)-(C2 -C6 Alkenyl, C(O)O-(C2 -C6 Alkenyl, (C1 -C4 )alkyl-O-(C1 -C4 )alkyl, (C1 -C4 )alkyl-S(O)n -(C1 -C4 )alkyl, C(O)-(C1 -C4 )alkyl-C(O)O-(C1 -C4 An alkyl group, a phenyl group, and a phenoxy group;(N) n Each of which is independently 0, 1, or 2; and the N-oxide of the molecule of Formula 1, an agriculturally acceptable acid addition salt, a salt derivative, a solvate, a crystalline polymorph, an isotope , resolved stereoisomers, and tautomers.2D. Such as1D Molecule, of which(A) Ar 1 for(1a) (1a) , among them:(1) X 1 Is selected from N and CR 1 The group formed, and(2) R 1 ,R 2 , R 3 , R 4 andR 5 Each is independently selected from the group consisting of: H, Cl, (C1 -C4 Haloalkyl and (C1 -C4 Haloalkoxy;(B) Het for(1b) (1b) , among them,R 6 Is H;(C) L 1 Is selected from the group consisting of the following (1c) , (1d) , and (1e) , where eachR 7 ,R 8 , R 9 andR 10 Is independently selected from H and (C1 -C4 a group of alkyl groups;(D) Ar 2 for(1f) (1f) , among them:(1) X 2 Is selected from N and CR 13 The group formed, and(2) R 11 ,R 12 , R 13 andR 14 Each is independently selected from the group consisting of: H, F, Cl, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C1 -C4 Alkoxy, and C(O)O-(C1 -C4 )alkyl;(E)R 15 Is H;(F) Q 1 Is O;(G)Q 2 Is S;(H)R 16 for(K) ;(I)R 17 for(K) ;(J) L 2 Is selected from the group consisting of the following (1g) and (1h) , among themR 20 ,R 21 , R 22 , R 23 andR 24 Each is independently selected from the group consisting of: H, F, Cl, (C1 -C4 )alkyl, (C1 -C4 Haloalkyl, (C3 -C8 )cycloalkyl, (C1 -C4 Alkoxy group, (C1 -C4 Haloalkoxy, and (C1 -C4 )alkyl-O-(C1 -C4 Alkyne;(K) R 16 andR 17 versusC x (Q 2 )(N x ) Together, it is selected from the group consisting of (1i) and (1j) , among themR 18 andR 19 Each is H.3D. Such as 1D or 2D molecules, of which(A) Ar 1 for(1a) (1a) , among them:(1) X 1 Is selected from N and CR 1 The group formed, and(2) R 1 ,R 2 , R 3 , R 4 andR 5 Each is independently selected from the group consisting of: H, Cl, CF3 And OCF3 ;(B) Het for(1b) (1b) , among them,R 6 Is H;(C) L 1 Is selected from the group consisting of the following (1c) , (1d) , and (1e) , where eachR 7 ,R 8 , R 9 andR 10 Lines are independently selected from H and CH3 The group formed;(D) Ar 2 for(1f) (1f) , among them:(1) X 2 Is selected from N and CR 13 The group formed, and(2) R 11 ,R 12 , R 13 andR 14 Each is independently selected from the group consisting of H, F, Cl, CH3 , CF3 OCH3 And C(O)O-CH3 ;(E)R 15 Is H;(F) Q 1 Is O;(G)Q 2 Is S;(H)R 16 for(K) ;(I)R 17 for(K) ;(J) L 2 It is selected from the following group: (1g) and (1h) , among them,R 20 ,R 21 , R 22 , R 23 andR 24 Each is independently selected from the group consisting of H, F, Cl, CH3 , CH2 CH2 CH3 , CH (CH3 )2 , CF3 , cyclopropyl, OCH3 OCH2 CH3 , OCH (CH3 )2 , OC (CH3 )3 , OCH (CH3 )CH2 CH3 OCF3 OCH2 CF3 , CH2 OCH3 , and CH (CH3 )OCH3 ;as well as(K) R 16 andR 17 versusC x (Q 2 )(N x ) Together, it is selected from the group consisting of (1i) and (1j) , among themR 18 andR 19 Each is H.4D. a molecule such as 1D, 2D or 3D, wherein the molecule is 5D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising an active ingredient.6D. An insecticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising an active ingredient selected from the group consisting of an acaricide, an algaecide, a food repellent, a bird killing agent (avicide), fungicide, bird repellent, chemical sterilization agent, fungicide, herbicide safener, herbicide, insect attractant, insect repellent, insecticide, mammalian, mating interference, killing Agents, nematicides, plant activators, plant growth regulators, rodenticides, synergists, and virucides.7D. An insecticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising selected fromAIGA Active ingredient.8D. An insecticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprisingAI–1 .9D. An insecticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprisingAI–2 .10D. An insecticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprisingRotiran (Lotilaner) .11D. An insecticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising selected fromtable A The molecule.12D. An insecticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising selected fromAIGA–2 Active ingredient.13D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising chlorpyrifos.14D. A pesticidal composition comprising a molecule such as any of 1D, 2D, 3D or 4D, further comprising a hexaflumuron.15D. An insecticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising methoxyfenozide.16D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising a polyfluuron.17D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising spinetoram.18D. A pesticidal composition comprising a molecule such as any of 1D, 2D, 3D or 4D, further comprising spinosad.19D. An insecticidal composition comprising a molecule such as 1D, 2D, 3D or 4D further comprising sulfoxaflor.20D. An insecticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising selected fromAIGA–2 Active ingredient.21D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising an acequinocyl.22D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprising acetamiprid.23D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising acetoprole.24D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising avermectin.25D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D further comprising azinphos-methyl.26D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising bifenazate.27D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising bifenthrin.28D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising a carbaryl.29D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprising a carbofuran.30D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprising chlorfenapyr.31D. An insecticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising chlorfluazuron.32D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising chromafenozide.33D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising a clothianidin.34D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising cyfluthrin.35D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising cypermethrin.36D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprising deltamethrin.37D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising diafenthiuron.38D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising emamectin benzoate.39D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprising endosulfan.40D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising an esfenvalerate.41D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising ethiprole.42D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprising etoxazole.43D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising fipronil.44D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising flonicamid.45D. An insecticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising a fluacrypyrim.46D. An insecticidal composition comprising a molecule such as 1D, 2D, 3D or 4D further comprising γ-cylon (Gamma -cyhalothrin).47D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising halofenozide.48D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising indoxacarb.49D. An insecticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising λ-cylon (Lambda -cyhalothrin).50D. A pesticidal composition comprising a molecule such as any of 1D, 2D, 3D or 4D, further comprising lufenuron.51D. A pesticidal composition comprising a molecule such as any of 1D, 2D, 3D or 4D, further comprising a malathion.52D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising a methodyl.53D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising novaluron.54D. A pesticidal composition comprising a molecule such as any of 1D, 2D, 3D or 4D, further comprising permethrin.55D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising pyridalyl.56D. An insecticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising pyrimidifen.57D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising spirodiclofen.58D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising tebufenozide.59D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprising thiacloprid.60D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising thiamethoxam.61D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprising thiodicarb.62D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising tolfenpyrad.63D. An insecticidal composition comprising a molecule such as 1D, 2D, 3D or 4D, further comprising ζ-赛宁宁.64D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D or 4D, further comprising a biological insecticide.65D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingAcetylcholinesterase (AChE) Inhibitor Active ingredient.66D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingAcetylcholinesterase (AChE) Inhibitor Active ingredient.67D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingGABA- Gated controlled chloride channel antagonist Active ingredient.68D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingSodium ion channel regulator Active ingredient.69D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingsmoke Alkaline acetylcholine (nAChR) Synergistic agent Active ingredient.70D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingsmoke Alkaline acetylcholine receptor (nAChR) Allosteric activator Active ingredient.71D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingChloride channel activator Active ingredient.72D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingJuvenile hormone mimetic Active ingredient.73D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingMiscellaneous non-specific ( Multiple positions) Inhibitor Active ingredient.74D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingString organ (Chordotonal Organs ) Conditioner Active ingredient.75D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingGrowth inhibitor Active ingredient.76D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingMicroorganisms that destroy insect midgut Active ingredient.77D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingGranular gland ATP Synthetic enzyme inhibitor Active ingredient.78D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingOxidative phosphorylation non-coupling agent via disruption of proton gradient Active ingredient.79D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingsmoke Alkaline acetylcholine receptor (nAChR) Channel blocker Active ingredient.80D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingChitin biosynthesis inhibitor, number 0 type , the active ingredient.81D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingChitin biosynthesis inhibitor, first type , the active ingredient.82D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingDiptera peeling interferer Active ingredient.83D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingEcdysone receptor synergist Active ingredient.84D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingOctopamine receptor synergist Active ingredient.85D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingGranular gland complex III Electron transport inhibitor Active ingredient.86D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingGranular gland complex I Electron transport inhibitor Active ingredient.87D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingVoltage- Dependent sodium channel blocker Active ingredient.88D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingAcetylene Kiev A Carboxylase inhibitor Active ingredient.89D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingGranular gland complex IV Electron transport inhibitor Active ingredient.90D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingGranular gland complex II Electron transport inhibitor Active ingredient.91D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingRhone Dan Device (R Yanodine receptor) Conditioner Active ingredient.92D. An insecticidal composition comprising a molecule of any of 1D, 2D, 3D or 4D, further comprisingUN group Active ingredient.93D. An insecticidal composition, such as 5D to and including any one of 92D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 100:1 to 1:100.94D. An insecticidal composition, such as 5D to and including any one of 92D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 50:1 to 1:50.95D. An insecticidal composition, such as 5D to and including any one of 92D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 20:1 to 1 to 20.96D. An insecticidal composition, such as 5D to and including any one of 92D, wherein the weight ratio of the molecule of Formula 1 to the active ingredient is from 10:1 to 1:10.97D. An insecticidal composition, such as 5D to and including any one of 92D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 5:1 to 1:5.98D. An insecticidal composition, such as 5D to and including any one of 92D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 3:1 to 1:3.99D. An insecticidal composition, such as 5D to and including any of 92D, wherein the weight ratio of the molecule of Formula 1 to the active ingredient is from 2:1 to 1:2.100D. An insecticidal composition, such as 5D to and including any one of 92D, wherein the weight ratio of the molecule of Formula 1 to the active ingredient is 1:1.101D. An insecticidal composition, such as 5D to include any one of 92D, wherein the weight ratio of the molecule of formula 1 to the active ingredient isX:Y ;among themX Is the weight of the molecule of formula 1 andY Is a part by weight of the active ingredient; further whereinX The range of parts by weight is 0 <X ≤ 100 andY The range of parts by weight is 0 <Y ≤ 100; and further among themX andY Selected from Table C.102D. For example, the insecticidal composition of 101D, wherein the weight ratio of the molecular weight of the formula 1 to the active ingredient isX 1 :Y 1 toX 2 :Y 2 FurtherX 1 >Y 1 AndX 2 <Y 2 .103D. For example, the insecticidal composition of 101D, wherein the weight ratio of the molecular weight of the formula 1 to the active ingredient isX 1 :Y 1 toX 2 :Y 2 FurtherX 1 >Y 1 AndX 2 >Y 2 .104D. For example, the insecticidal composition of 101D, wherein the weight ratio of the molecular weight of the formula 1 to the active ingredient isX 1 :Y 1 toX 2 :Y 2 FurtherX 1 <Y 1 AndX 2 <Y 2 .105D An insecticidal composition according to any one of 5D to 104D, wherein the insecticidal composition further comprises ammonium sulfate.106D. An insecticidal composition, such as 5D to and including any of 105D, wherein the pesticidal composition is synergistic.107D. A method of producing a pesticidal composition, the method comprising mixing a molecule of any one of claims 1D, 2D, 3D or 4D with one or more active ingredients.108D. A method of testing a pesticidal composition such as 107D to determine if it is synergistic.109D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D or 4D and a seed.110D. A molecule of any of 1D, 2D, 3D or 4D, wherein the molecule is in the form of an agriculturally acceptable acid addition salt.111D. A molecule such as 1D, 2D, 3D or 4D, wherein the molecule is in the form of a salt derivative.112D. A molecule such as 1D, 2D, 3D or 4D, wherein the molecule is in the form of a solvate.113D. A molecule such as 1D, 2D, 3D or 4D, wherein the molecule is in the form of an ester derivative.114D. A molecule such as 1D, 2D, 3D or 4D, wherein the molecule is in the form of a crystalline polymorph.115D. A molecule such as 1D, 2D, 3D or 4D wherein the molecule has ruthenium, osmium, radiocarbon or a combination thereof.116D. A molecule of any of 1D, 2D, 3D or 4D, wherein the molecule is in the form of one or more stereoisomers.117D. A molecule of any of 1D, 2D, 3D or 4D, wherein the molecule is in the form of a resolved stereoisomer.118D. A method of controlling pests, comprising applying a pesticidally effective amount of a molecule such as 1D, 2D, 3D or 4D to a locus.119D. A method of controlling pests, comprising applying a pesticidally effective amount of an insecticidal composition, such as 5D to and including any of 106D, to a locus.120D. A method according to 118D or 119D, wherein the pest is selected from the group consisting of an ant, a locust, a bed bug, a beetle, a bristletails, a caterpillar, a donkey, a donkey, an earwig, a flea, a fly, a dragonfly,螬, leaf 蝉, 虱, 蝗 蛆, 蛆, 螨, nematode, planthopper, psyllids, sawflies, scale insects, silverfish, snails, snails, spiders , caterpillars, bed bugs, symphylans, termites, thrips, ticks, wasps, whiteflies, and wireworms.121D. A method of 118D or 119D, wherein the pest is selected fromSubphyla Chelicerata , more than Yamen (Myriapoda) , or the hexapod (Hexapoda) .122D. A method of 118D or 119D, wherein the pest is selected fromArachnida (Arachnida) Comprehensive outline (Symphyla) , or Insecta (Insecta) . 123D. A method of 118D or 119D, wherein the pest is selected fromAttention (Order Anoplura) .124D. A method of 118D or 119D, wherein the pest is selected fromColeoptera (Order Coleoptera) .125D. A method of 118D or 119D, wherein the pest is selected fromGenus (Order Dermaptera) .126D. A method of 118D or 119D, wherein the pest is selected fromAttention (Order Blattaria) .127D. A method of 118D or 119D, wherein the pest is selected fromDiptera (Order Diptera) .128D. A method of 118D or 119D, wherein the pest is selected fromHemiptera (Order Hemiptera) .129D. A method of 118D or 119D, wherein the pest is selected fromHymenoptera (Order Hymenoptera) .130D. A method of 118D or 119D, wherein the pest is selected fromIsoptera (Order Isoptera) .131D. A method of 118D or 119D, wherein the pest is selected fromLepidoptera (Order Lepidoptera) .132D. A method of 118D or 119D, wherein the pest is selected fromFood (Order Mallophaga) .133D. A method of 118D or 119D, wherein the pest is selected fromOrthoptera (Order Orthoptera) .134D. A method of 118D or 119D, wherein the pest is selected fromRodent ( Order Psocoptera ) .135D. A method of 118D or 119D, wherein the pest is selected fromAttention (Order Siphonaptera) .136D. A method of 118D or 119D, wherein the pest is selected fromThysanoptera (Order Thysanoptera) .137D. A method of 118D or 119D, wherein the pest is selected fromIris (Order Thysanura) .138D. A method of 118D or 119D, wherein the pest is selected fromAttention (Order Acarina) .139D. A method of 118D or 119D, wherein the pest is selected fromTrue spider (Order Araneae ) .140D. A method of 118D or 119D, wherein the pest is selected fromKnot valve (Class Symphyla ) .141D. A method of 118D or 119D, wherein the pest is selected fromSticky tube (Subclass Collembola ) .142D. A method of 118D or 119D, wherein the pest is selected fromRound animal door (Phylum Nematoda) .143D. A method of 118D or 119D, wherein the pest is selected fromMollusc door ( Phylum Mollusca ) .144D. A method of, for example, 118D or 119D, wherein the pest is a pest that feeds on the juice.145D. A method according to 144D, wherein the pest is selected from the group consisting of aphids, spider mites, moths, scales, thrips, psyllids, melybugs, bed bugs, and whiteflies.146D. A method of 144D, wherein the pest is selected from the group consisting of Order Anoplura and Order Hemiptera.147D. A method of 144D, wherein the pest is selected from the group consisting of the genusAulacaspis Spp.)Aphrophora Spp.), aphid (Aphis Spp.), whiteflyBemisia Spp.), scales (Coccus Spp.), American genus (Euschistus Spp.)Lygus Spp.)Macrosiphum Spp.), genusNezara Spp.), and the genusRhopalosiphum Spp.).148D. A method of, for example, 118D or 119D, wherein the pest is a chewy pest.149D. A method of 148D, wherein the pest is selected from the group consisting of caterpillars, beetles, mites, and mites.150D. The method of 148D, wherein the pest is selected from the group consisting of Coleoptera and Lepidoptera.151D. A method of 148D, wherein the pest is selected from the group consisting of the genusAcanthoscelides Spp.), Bean Leaf Beetle (Cerotoma Spp.)Chaetocnema Spp.), shawl beetle (Colaspis Spp.), round-headed rhinoceros (Cyclocephala Spp.), genusDiabrotica Spp.)Hypera Spp.)Phyllophaga Spp.)Phyllotreta Spp.), Wormidae (Sphenophorus Spp.), Mixiang (Sitophilus Spp.).152D. Such as the method of 118D or 119D, wherein the location is alfalfa, almond, apple, barley, beans, rape, corn, cotton, cruciferous, lettuce, oats, oranges, peanuts, pears, peppers, potatoes, rice, sorghum. , soybeans, strawberries, sugar cane, sugar beets, sunflowers, tobacco, tomatoes, wheat, and other valuable crops grown or where they are grown.153D. A method of, for example, 118D or 119D, wherein the locus is genetically modified to represent a particular trait of planting.154D. A method of, for example, 118D or 119D, wherein the applying is carried out on a plant leaf and/or fruit portion.155D. A method of, for example, 118D or 119D, wherein the application is carried out in soil.156D. A method according to 118D or 119D, wherein the application is carried out by drip irrigation, strip application, or soil watering before or after planting.157D. A method of, for example, 118D or 119D, wherein the application is carried out on a plant leaf and/or fruit portion, or by pre-planting the plant seed.158D. A method comprising administering a molecule, such as 1D, 2D, 3D or 4D, to a seed.159D. A method comprising administering a molecule such as 1D, 2D, 3D or 4D to a locus comprising non-human animal breeding fields to control parasites, ectoparasites and both.

本文件中之標題僅為方便且不能用於解釋本文件之任何部份。表 表B 表 C 表2. F 系列分子之結構和製備方法 * 依據 實施例編號 來製備 表3. C 系列分子之結構和製備方法 * 依據 實施例編號 來製備 表4 ：表2 中化合物之分析數據 表ABC ：生物結果 The headings in this document are for convenience only and should not be used to interpret any part of this document. Table B Table C Table 2. Structure and preparation method of F series molecules * Prepare according to the example number . Table 3. Structure and preparation method of C series molecules * Prepare Table 4 for the analysis of the compounds in Table 2 according to the example numbers . Table ABC : Biological Results

(無)(no)

Claims (8)

一種具下式之分子 式1 其中：(A) Ar1 係選自於下列所構成的群組：呋喃基、苯基、嗒基、吡啶基、嘧啶基，或是噻吩基， 其中每個呋喃基、苯基、嗒基、吡啶基、嘧啶基，及噻吩基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(B) Het 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子，以及其中Ar1 與L1 互相不為鄰位，但可為間位或對位，例如就5員環而言，其等為1,3，且就6員環而言，其等為1,3或1,4， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(C) L1 係選自於下列所構成的群組：(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基，以及(C2 -C6 )炔基， 其中每個烷基、鹵烷基、環烷基、烯基及炔基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基，以及(C2 -C6 )炔基；(D)       Ar2 係選自於下列所構成的群組：呋喃基、苯基、嗒基、吡啶基、嘧啶基，或是噻吩基， 其中每個呋喃基、苯基、嗒基、吡啶基、嘧啶基，及噻吩基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(E) R15 係選自於下列所構成的群組：H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、C(O)-NRx Ry 、C(O)-苯基、(C1 -C4 )烷基-NRx Ry 、C(O)O-(C1 -C4 )烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基，以及(C1 -C4 )烷基-OC(=O)O-(C1 -C4 )烷基， 其中每個烷基、環烷基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(F) Q1 係選自於O及S所構成的群組；(G)       Q2 係選自於O及S所構成的群組；(H) R16 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基)、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(I) R17 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(J) L2 係選自於下列所構成的群組：(C3 -C8 )環烷基、苯基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、(C2 -C6 )烯基-O-苯基、(Het-1)、(C1 -C4 )烷基-(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)；(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起形成一個4-至7-員飽和或不飽和之烴基環(hydrocarbyl cyclic)基團，其可以進一步含有選自於氮、硫或氧所構成的群組之一個或更多個雜原子， 其中該烴基環基團可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：側氧、R18 及R19 ， 其中R18 及R19 係各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、側氧、硫酮基、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(L) Rx 及Ry 係各自獨立地選自於下列所構成的群組：H、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基，以及苯基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(M)      (Het-1) 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(N) n 每一者係獨立地為0、1或2；以及式1的分子之N-氧化物、農業上可接受的酸加成鹽類、鹽類衍生物、溶劑合物、結晶性多形體、同位素、解析的立體異構物，以及互變異構物。a molecule with the following formula Formula 1 wherein: (A) Ar 1 is selected from the following group consisting of: furyl, phenyl, despair a pyridyl group, a pyrimidinyl group, or a thienyl group, wherein each furanyl group, phenyl group, hydrazine group The base, pyridyl, pyrimidinyl, and thienyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 - C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n - (C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-( C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-( C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl -O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 An alkyl-C(O)O-(C 1 -C 4 )alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group Alkenyl, alkynyl, phenyl, and phenoxy substituted May be selectively one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkoxy , (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C (O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C (O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkane , (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-( C 1 -C 4 )alkyl, phenyl, and phenoxy; (B) Het is a 5 or 6 membered, saturated or unsaturated heterocyclic ring containing one or more independently selected from nitrogen, sulfur or oxygen. heteroatoms, and wherein each Ar 1 to L 1 is not ortho However, it may be a meta or para position, for example, for a 5-membered ring, it is 1, 3, and for a 6-membered ring, it is 1, 3 or 1, 4, wherein each heterocyclic ring may be selected. Sexually substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C 4 ) Alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl , OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) Alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O- (C 1 -C 4) alkyl, phenyl, and phenoxy, wherein each alkyl Haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, phenyl, and phenoxy substituents may be optionally selected from one or more independently selected from the following Substituents of the group are substituted: H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 ) cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S (O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C (O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C( O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O) O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n - (C 1 -C 4) alkyl, C (O) - (C 1 -C 4) alkyl -C (O) O- (C 1 -C 4) alkyl, phenyl, and phenoxy; ( C) L 1 is selected from the group consisting of: (C 1 -C 4 ) alkane a (C 1 -C 4 )haloalkyl group, a (C 3 -C 8 )cycloalkyl group, a (C 2 -C 6 )alkenyl group, and a (C 2 -C 6 )alkynyl group, wherein each alkyl group The haloalkyl, cycloalkyl, alkenyl and alkynyl groups may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I. , CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, ( C 1 -C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, and (C 2 -C 6 )alkynyl; (D) Ar 2 is selected from the group consisting of furanyl Phenyl, hydrazine a pyridyl group, a pyrimidinyl group, or a thienyl group, wherein each furanyl group, phenyl group, hydrazine group The base, pyridyl, pyrimidinyl, and thienyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 - C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n - (C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-( C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-( C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl -O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 An alkyl-C(O)O-(C 1 -C 4 )alkyl group, a phenyl group, and a phenoxy group, wherein each alkyl group, haloalkyl group, cycloalkyl group, alkoxy group, haloalkoxy group Alkenyl, alkynyl, phenyl, and phenoxy substituted May be selectively one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkoxy , (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C (O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C (O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkane , (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O)O- (C 1 -C 4 )alkyl, phenyl, and phenoxy; (E) R 15 is selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 3 - C 8) cycloalkyl, (C 2 -C 6) alkenyl, (C 2 -C 6) alkynyl group, S (O) n - ( C 1 -C 4) alkoxy , C (O) -NR x R y, C (O) - phenyl, (C 1 -C 4) alkyl group -NR x R y, C (O ) O- (C 1 -C 4) alkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C( O) O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O) -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, and (C 1 -C 4 )alkyl-OC ( =O)O-(C 1 -C 4 )alkyl, wherein each alkyl, cycloalkyl, alkenyl, alkynyl, and phenyl group may be optionally independently selected from one or more of the following The substituents of the group formed are substituted: H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 Alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 Alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 ) alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O)O-(C 1 -C 4 ) alkyl, phenyl, and phenoxy; (F) Q 1 is selected from O and S in the group consisting of; (G) Q 2 is selected from O and S in the group consisting of; (H) R 16 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, C(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, C(O)-(Het-1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-C(O)-( Het-1), (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (NR x R y )-C(O)OH, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-NR x R y ,(C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-C(O)-N (R x )(C 1 -C 4 )alkyl (N(R x )-C(O)O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 ) Alkyl-C(O)-(Het-1)-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3 - C 8 ) cycloalkyl, (C 1 -C 4 )alkyl-OC(O)-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 ) Alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl- S(O) n -(Het-1), and (C 1 -C 4 )alkyl-O-(Het-1), wherein each alkyl group, cycloalkyl group, alkenyl group, alkynyl group, phenyl group, And (Het-1) may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkane a group, (C 1 -C 4 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(=O) n -(C 1 -C 4 )alkyl, S(=O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H , C(O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O) -(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O- (C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl), phenyl, phenoxy, Si(( C 1 -C 4 )alkyl) 3 , S(=O) n -NR x R y , and (Het-1); (I) R 17 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, C(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 - C 4 )alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, C(O )-(Het-1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 ) Alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 Alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-C(O)-(Het-1), (C 1 -C 4 )alkyl-C(O)-N(R x (C 1 -C 4 )alkyl (NR x R y )-C(O)OH, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 ) Alkyl-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-N(R x )-C(O)O- (C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (N(R x )-C(O) O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 )alkyl-C(O)-(Het-1)-C(O)O-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkyl-OC(O)-(Het -1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl (C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 )alkyl-S(O) n -(Het-1), and (C 1 -C 4 )alkyl -O-(Het-1), wherein each alkyl group, cycloalkyl group, alkenyl group, alkynyl group, phenyl group, and (Het-1) may be optionally selected from one or more independently selected from the following The substituents of the group formed are substituted: H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )halane , (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(=O) n -(C 1 -C 4 )alkyl, S(=O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 ) haloalkyl, C(O)H, C(O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 - C 4 ) haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 ) alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 ) Alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, Phenyl, phenoxy, Si((C 1 -C 4 )alkyl) 3 , S(=O) n -NR x R y , and (Het-1); (J) L 2 selected From the group consisting of: (C 3 -C 8 )cycloalkyl, phenyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, (C 2 -C 6 )alkenyl-O-phenyl, (Het-1), (C 1 -C 4 )alkyl-(Het-1), and (C 1 -C 4 )alkyl-O- (Het-1), wherein each alkyl group, cycloalkyl group, alkenyl group, phenyl group, and (Het-1) may be optionally selected from the group consisting of one or more independently selected from the group consisting of Substituents are substituted: H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 - C 8 ) cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -( C 1 -C 4 )haloalkyl, C(O)H, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 - C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 Haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 ) alkenyl group, C (O) O- (C 2 -C 6) alkenyl, O- (C 1 -C 4) alkoxy , S- (C 1 -C 4) alkyl, (C 1 -C 4) alkyl -O- (C 1 -C 4) alkyl, C (O) - (C 1 -C 4) alkyl - C(O)O-(C 1 -C 4 )alkyl, phenyl, phenoxy, and (Het-1), wherein each alkyl, cycloalkyl, alkenyl, phenyl, and (Het- 1) The substituent may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , NR x R y (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 Haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C( O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O O-(C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, O-(C 1 -C 4) -alkyl, S- (C 1 -C 4) alkyl, (C 1 -C 4) alkyl -O- (C 1 -C 4) alkoxy , C (O) - (C 1 -C 4) alkyl -C (O) O- (C 1 -C 4) alkyl, phenyl, phenoxy, and (Het-1); (K ) R 16 and R 17 together with C x (Q 2 )(N x ) form a 4- to 7-membered saturated or unsaturated hydrocarbyl cyclic group which may further contain a nitrogen, sulfur or oxygen selected from nitrogen, sulfur or oxygen. One or more heteroatoms of the group formed, wherein the hydrocarbyl ring group may be optionally substituted with one or more substituents independently selected from the group consisting of: side oxygen, R 18 and R 19 , wherein R 18 and R 19 are each independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, thioketone, (C) 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )halane Oxyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 ) haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-(C 1 -C 4 Alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )halide Alkyl, C(O)-(C 3 - C 8 ) cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 ) alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 ) Alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and (Het-1); (L) R x and R y is each independently selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -( C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )halide Alkyl, C(O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 ) haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 ) cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-( C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl- C (O) O- (C 1 -C 4) alkyl, and phenyl, wherein each alkyl, halo The group, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, and phenyl may be optionally substituted with one or more substituents independently selected from the group consisting of : H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1- C 4 ) alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl , C(O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 ) Haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 ) Cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C( O) O-(C 1 -C 4 )alkyl, phenyl, and (Het-1); (M) (Het-1) is a 5- or 6-membered, saturated or unsaturated heterocyclic ring containing independently selected From one or more heteroatoms of nitrogen, sulfur or oxygen, Each heterocycle may optionally one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, an oxygen side, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 ) Haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 ) haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 ) alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 - C 4 ) haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 - C 8 ) cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O- (C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl -C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl , alkynyl, phenyl, and phenoxy substituents can be selected The one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkyl, ( C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 Alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 - (C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C (O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O) O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O) -(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, ( C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 - C 4 ) alkyl, phenyl, and phenoxy; (N) n each independently 0, 1 or 2; and the N-oxide of the molecule of formula 1, agriculturally acceptable acid addition Salts, salt derivatives, solvates, crystalline polymorphs, same Su, resolved stereoisomers, and tautomers thereof. 如請求項1之分子，其中：(A) Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(B) Het 為(1b) (1b) ， 其中R6 可以選擇性地以選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(C) L1 係選自於下列所構成的群組： (1c) ， (1d) ，及 (1e) ， 其中R7 、R8 、R9 及R10 係各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基，以及(C2 -C6 )炔基；(D)       Ar2 為(1f) (1f) ， 其中：(1) X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 、 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(E) R15 係選自於下列所構成的群組：H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、C(O)-NRx Ry 、C(O)-苯基、(C1 -C4 )烷基-NRx Ry 、C(O)O-(C1 -C4 )烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基，以及(C1 -C4 )烷基-OC(=O)O-(C1 -C4 )烷基， 其中每個烷基、環烷基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(=O)O-(C1 -C4 )烷基、苯基，以及苯氧基；(F) Q1 係選自於O及S所構成的群組；(G)       Q2 係選自於O及S所構成的群組；(H) R16 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基)、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(I) R17 係選自於下列所構成的群組：(K) 、H、(C1 -C4 )烷基、(C3 -C8 )環烷基、(C2 -C6 )烯基、(C2 -C6 )炔基、C(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、(C1 -C4 )烷基苯基、(C1 -C4 )烷基-O-苯基、C(O)-(Het-1)、Het-1、(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-(Het-1)、(C1 -C4 )烷基-C(O)-(Het-1)、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(NRx Ry )-C(O)OH、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-C(O)-N(Rx )(C1 -C4 )烷基(N(Rx )-C(O)O-(C1 -C4 )烷基)-C(O)OH、(C1 -C4 )烷基-C(O)-(Het-1)-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基、(C1 -C4 )烷基-OC(O)-(C3 -C8 )環烷基、(C1 -C4 )烷基-OC(O)-(Het-1)、(C1 -C4 )烷基-OC(O)-(C1 -C4 )烷基-N(Rx )-C(O)O-(C1 -C4 )烷基、(C1 -C4 )烷基-NRx Ry 、(C1 -C4 )烷基-S(O)n -(Het-1)，以及(C1 -C4 )烷基-O-(Het-1)， 其中每個烷基、環烷基、烯基、炔基、苯基，及(Het-1)可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(=O)n -(C1 -C4 )烷基、S(=O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)OH、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基、Si((C1 -C4 )烷基)3 、S(=O)n -NRx Ry ，以及(Het-1)；(J) L2 係選自於下列所構成的群組： (1g) 及 (1h) ， 其中R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)， 其中每個烷基、環烷基、烯基、苯基，及(Het-1)取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、NRx Ry 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C1 -C4 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、O-(C1 -C4 )烷基、S-(C1 -C4 )烷基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基、苯氧基，以及(Het-1)；(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組： (1i) 及 (1j) ， 其中R18 及R19 係各自獨立地選自於下列所構成的群組：H 、F、Cl、Br、I、CN、NO2、側氧、硫酮基、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(L) Rx 及Ry 係各自獨立地選自於下列所構成的群組：H、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基，以及苯基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基，及苯基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)H、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及(Het-1)；(M)      (Het-1) 為5或6員、飽和或不飽和之雜環，含有獨立地選自於氮、硫或氧之一或多個雜原子， 其中每個雜環可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、側氧、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，以及苯氧基， 其中每個烷基、鹵烷基、環烷基、烷氧基、鹵烷氧基、烯基、炔基、苯基，及苯氧基取代基可以選擇性地以一個或更多個獨立地選自於下列所構成的群組之取代基予以取代：H、F、Cl、Br、I、CN、NO2 、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基、(C2 -C6 )烯基、(C2 -C6 )炔基、S(O)n -(C1 -C4 )烷基、S(O)n -(C1 -C4 )鹵烷基、OSO2 -(C1 -C4 )烷基、OSO2 -(C1 -C4 )鹵烷基、C(O)-NRx Ry 、(C1 -C4 )烷基-NRx Ry 、C(O)-(C1 -C4 )烷基、C(O)O-(C1 -C4 )烷基、C(O)-(C1 -C4 )鹵烷基、C(O)O-(C1 -C4 )鹵烷基、C(O)-(C3 -C8 )環烷基、C(O)O-(C3 -C8 )環烷基、C(O)-(C2 -C6 )烯基、C(O)O-(C2 -C6 )烯基、(C1 -C4 )烷基-O-(C1 -C4 )烷基、(C1 -C4 )烷基-S(O)n -(C1 -C4 )烷基、C(O)-(C1 -C4 )烷基-C(O)O-(C1 -C4 )烷基、苯基，及苯氧基；以及(N) n 每一者係獨立地為0、1或2。The numerator of claim 1, wherein: (A) Ar 1 is (1a) (1a) wherein: (1) X 1 is selected from the group consisting of N and C R 1 , and (2) R 1 , R 2 , R 3 , R 4 and R 5 are each independently selected from Groups consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 ) Cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 - C 4 ) haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O) -(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O- (C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, each of which Alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, phenyl, and phenoxy May be selectively one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkoxy , (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C (O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C (O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkane , (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-( C 1 -C 4 )alkyl, phenyl, and phenoxy; (B) Het is (1b) (1b) wherein R 6 may be optionally substituted with a substituent selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 ) alkane , (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C (O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C (O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) alkane , (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-( C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, phenyl, and The phenoxy group may be optionally selected from one or more independently selected from Column group consisting of the substituent group to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) alkyl, (C 1 -C 4) halo -alkyl, (C 3- C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl,(C 2 -C 6 )alkyne , S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 ) alkane , C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl , C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C (O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy (C) L 1 is selected from the group consisting of: (1c) , (1d) , and (1e) wherein R 7 , R 8 , R 9 and R 10 are each independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C) 4 ) an alkyl group, a (C 1 -C 4 )haloalkyl group, a (C 3 -C 8 )cycloalkyl group, a (C 1 -C 4 )alkoxy group, a (C 1 -C 4 )halo alkoxy group, (C 2 -C 6 )alkenyl, and (C 2 -C 6 )alkynyl; (D) Ar 2 is (1f) (1f) wherein: (1) X 2 is selected from the group consisting of N and C R 13 , and (2) R 11 , R 12 , R 13 , and R 14 are each independently selected from the following Groups formed: H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkane , (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 Haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-( C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 - C 4 ) alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkyl group , haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, phenyl, and benzene Groups may optionally one or more substituents independently selected from the group consisting of the following substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, (C 1 -C 4) Alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl , OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 ) Alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O)O -(C 1 -C 4 )alkyl, phenyl, and phenoxy; (E) R 15 is selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 3 -C 8) cycloalkyl, (C 2 -C 6) alkenyl, (C 2 -C 6) alkynyl group, S (O) n - ( C 1 -C 4) Group, C (O) -NR x R y, C (O) - phenyl, (C 1 -C 4) alkyl group -NR x R y, C (O ) O- (C 1 -C 4) alkyl , C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C (O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O )-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, and (C 1 -C 4 )alkyl-OC (=O)O-(C 1 -C 4 )alkyl, wherein each alkyl, cycloalkyl, alkenyl, alkynyl, and phenyl group may be optionally selected from one or more independently selected from Substituents for the following group are substituted: H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 ) alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl , OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 ) alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O- (C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-( C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(=O)O-(C 1 -C 4) alkyl, phenyl, and phenoxy; (F) Q 1 is selected from O and S in the group consisting of; (G) Q 2 is selected from O and S in the group consisting of; ( H) R 16 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )ene , (C 2 -C 6 )alkynyl, C(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, ( C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-benzene , C(O)-(Het-1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-( C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )( C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-C(O) -(Het-1), (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (NR x R y )-C(O)OH, ( C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-NR x R y ,(C 1 -C 4 )alkyl-C(O)-N (R x )(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-C(O) -N(R x )(C 1 -C 4 )alkyl (N(R x )-C(O)O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 ) alkyl-C(O)-(Het-1)-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3- C 8 )cycloalkyl, (C 1 -C 4 )alkyl-OC(O)-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 ) alkyl-N(R x )-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-NR x R y , (C 1 -C 4 ) alkane -S(O) n -(Het-1), and (C 1 -C 4 )alkyl-O-(Het-1), wherein each alkyl, cycloalkyl, alkenyl, alkynyl, benzene The group, and (Het-1) may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , NR x R y, (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl, (C 3 -C 8) cycloalkyl Group, (C 1 -C 4) alkoxy, (C 2 -C 6) alkenyl, (C 2 -C 6) alkynyl, S (= O) n - (C 1 -C 4) alkyl, S(=O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H , C(O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O) -(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O- (C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl), phenyl, phenoxy, Si(( C 1 -C 4 )alkyl) 3 , S(=O) n -NR x R y , and (Het-1); (I) R 17 is selected from the group consisting of: (K) , H, (C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, C(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 - C 4 )alkyl, (C 1 -C 4 )alkylphenyl, (C 1 -C 4 )alkyl-O-phenyl, C (O)-(Het-1), Het-1, (C 1 -C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 ) alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 - C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 - C 4 )alkyl-(Het-1), (C 1 -C 4 )alkyl-C(O)-(Het-1), (C 1 -C 4 )alkyl-C(O)-N ( R x )(C 1 -C 4 )alkyl (NR x R y )-C(O)OH, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 ) alkyl-NR x R y , (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl-N(R x )-C(O) O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-C(O)-N(R x )(C 1 -C 4 )alkyl (N(R x )-C( O) O-(C 1 -C 4 )alkyl)-C(O)OH, (C 1 -C 4 )alkyl-C(O)-(Het-1)-C(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-( C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-OC(O)-(C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkyl-OC(O)- (Het-1), (C 1 -C 4 )alkyl-OC(O)-(C 1 -C 4 )alkyl-N(R x )-C(O)O-(C 1 -C 4 ) alkyl, (C 1 -C 4) alkyl group -NR x R y, (C 1 -C 4) alkyl -S (O) n - (Het -1), and (C 1 -C 4) alkoxy -O-(Het-1), wherein each alkyl group, cycloalkyl group, alkenyl group, alkynyl group, phenyl group, and (Het-1) may be optionally selected from one or more independently selected from the following The substituents of the group formed are substituted: H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )halane , (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(=O) n -(C 1 -C 4 )alkyl, S(=O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 ) haloalkyl, C(O)H, C(O)OH, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 - C 4 ) haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 ) alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 ) Alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, phenoxy, Si ((C 1 -C 4 ) alkyl) 3, S (= O) n -NR x R y, and (Het-1); (J ) L 2 based From the group consisting of the following: (1g) and (1h) wherein R 20 , R 21 , R 22 , R 23 and R 24 are each independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , NR x R y , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -( C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C (O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C( O) O-(C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, O-(C 1 -C 4 )alkyl, S-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, phenoxy, and (Het-1), wherein each alkyl, cycloalkyl, alkenyl, The phenyl, and (Het-1) substituents may be optionally selected from one or more independently selected from the following Into the group of substituents to be substituted with: H, F, Cl, Br , I, CN, NO 2, NR x R y, (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 ) alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl , OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O) -(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-( C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 1 -C 4 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, O-(C 1 -C 4 )alkyl, S-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl , phenyl, phenoxy, and (Het-1); (K) R 16 and R 17 together with C x (Q 2 )(N x ) are selected from the group consisting of: (1i) and (1j) wherein R 18 and R 19 are each independently selected from the group consisting of H , F, Cl, Br, I, CN, NO 2, pendant oxygen, thioketone, (C 1 -C) 4 ) an alkyl group, a (C 1 -C 4 )haloalkyl group, a (C 3 -C 8 )cycloalkyl group, a (C 1 -C 4 )alkoxy group, a (C 1 -C 4 )halo alkoxy group, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )halide Alkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-(C 1 -C 4 )alkyl , C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C( O) O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and (Het- 1); (L) R x and R y are each independently selected from the group consisting of H, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C) 3- C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 ) alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 Alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 ) alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 ) Cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 ) ene (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, and phenyl, wherein each alkyl, haloalkyl, cycloalkyl, alkane The oxy, haloalkoxy, alkenyl, alkynyl, and phenyl groups may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy a group, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -( C 1 -C 4 )haloalkyl, C(O)H, C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O )-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O) O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and (Het-1); (M) (Het-1) is 5 or 6 members, saturated or not a saturated heterocyclic ring containing one or more heteroatoms independently selected from nitrogen, sulfur or oxygen, wherein each heterocyclic ring may be optionally selected from the group consisting of one or more independently selected from the group consisting of Substituents substituted: H, F, Cl, Br, I, CN, NO 2 , pendant oxygen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 ) cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S (O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , (C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 )alkyl, C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 ) haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl, C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 ) cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C(O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-( C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O) n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl- C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy, wherein each alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, The alkynyl, phenyl, and phenoxy substituents may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN. , NO 2 , (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 ) haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, S(O) n -(C 1 -C 4 )alkyl, S(O) n -(C 1 -C 4 )haloalkyl, OSO 2 -(C 1 -C 4 )alkyl, OSO 2 -(C 1 -C 4 )haloalkyl, C(O)-NR x R y , ( C 1 -C 4 )alkyl-NR x R y , C(O)-(C 1 -C 4 ) alkane , C(O)O-(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )haloalkyl, C(O)O-(C 1 -C 4 )haloalkyl , C(O)-(C 3 -C 8 )cycloalkyl, C(O)O-(C 3 -C 8 )cycloalkyl, C(O)-(C 2 -C 6 )alkenyl, C (O)O-(C 2 -C 6 )alkenyl, (C 1 -C 4 )alkyl-O-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl-S(O n -(C 1 -C 4 )alkyl, C(O)-(C 1 -C 4 )alkyl-C(O)O-(C 1 -C 4 )alkyl, phenyl, and phenoxy And (N) n are each independently 0, 1, or 2. 如請求項1之分子，其中：(A) Ar1 為(1a) (1a) ， 其中：(1) X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、Cl、(C1 -C4 )鹵烷基及(C1 -C4 )鹵烷氧基；(B) Het 為(1b) (1b) ， 其中，R6 為H；(C) L1 係選自於下列所構成的群組： (1c) ， (1d) ， 及 (1e) ， 其中，每個R7 、R8 、R9 及R10 係獨立地選自於H 及(C1 -C4 )烷基 所構成的群組；(D)       Ar2 為(1f) (1f) ， 其中：(1) X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C1 -C4 )烷氧基，以及C(O)O-(C1 -C4 )烷基；(E)R15 為H；(F) Q1 為O；(G)Q2 為S；(H)R16 為(K) ；(I)R17 為(K) ；(J) L2 係選自於下列所構成的群組： (1g) 及 (1h) ， 其中R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、(C1 -C4 )烷基、(C1 -C4 )鹵烷基、(C3 -C8 )環烷基、(C1 -C4 )烷氧基、(C1 -C4 )鹵烷氧基，及(C1 -C4 )烷基-O-(C1 -C4 )烷基；以及(K)       R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組： (1i) 及 (1j) ， 其中R18 及R19 各自為H。The numerator of claim 1, wherein: (A) Ar 1 is (1a) (1a) wherein: (1) X 1 is selected from the group consisting of N and C R 1 , and (2) R 1 , R 2 , R 3 , R 4 and R 5 are each independently selected from The following group is composed of: H, Cl, (C 1 -C 4 )haloalkyl and (C 1 -C 4 )haloalkoxy; (B) Het is (1b) (1b) , wherein R 6 is H; (C) L 1 is selected from the group consisting of: (1c) , (1d) , and (1e) wherein each R 7 , R 8 , R 9 and R 10 are independently selected from the group consisting of H and (C 1 -C 4 ) alkyl ; (D) Ar 2 is (1f) ) (1f) wherein: (1) X 2 is selected from the group consisting of N and C R 13 , and (2) R 11 , R 12 , R 13 and R 14 are each independently selected from the following Group of: H, F, Cl, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, and C(O)O-( C 1 -C 4 )alkyl; (E) R 15 is H; (F) Q 1 is O; (G) Q 2 is S; (H) R 16 is (K) ; (I) R 17 is ( K) ; (J) L 2 is selected from the group consisting of: (1g) and (1h) wherein R 20 , R 21 , R 22 , R 23 and R 24 are each independently selected from the group consisting of H, F, Cl, (C 1 -C 4 )alkyl, (C 1 -C 4 ) haloalkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, and (C 1 -C 4 An alkyl-O-(C 1 -C 4 )alkyl group; and (K) R 16 and R 17 together with C x (Q 2 )(N x ) are selected from the group consisting of: (1i) and (1j) , wherein each of R 18 and R 19 is H. 如請求項1之分子，其中：(A) Ar1 為(1a) (1a) ， 其中：(1)  X1 係選自於N及CR1 所構成的群組，以及(2)R1 、R2 、R3 、R4 及R5 各自獨立地選自於下列所構成的群組：H、Cl、CF3 及OCF3 ；(B) Het 為(1b) (1b) ， 其中，R6 為H；(C) L1 係選自於下列所構成的群組： (1c) ， (1d) ， 及 (1e) ， 其中，每個R7 、R8 、R9 及R10 係獨立地選自於H及CH3 所構成的群組；(D) Ar2 為(1f) (1f) ， 其中：(1)  X2 係選自於N及CR13 所構成的群組，以及(2)R11 、R12 、R13 及R14 各自獨立地選自於下列所構成的群組：H、F、Cl、CH3 、CF3 、OCH3 ，以及C(O)O-CH3 ；(E)R15 為H；(F) Q1 為O；(G)Q2 為S；(H)R16 為(K) ；(I)R17 為(K) ；(J) L2 係選自於下列所構成的群組： (1g) 及 (1h) ， 其中，R20 、R21 、R22 、R23 及R24 各自獨立地選自於下列所構成的群組：H、F、Cl、CH3 、CH2 CH2 CH3 、CH(CH3 )2 、CF3 、環丙基、OCH3 、OCH2 CH3 、OCH(CH3 )2 、OC(CH3 )3 、OCH(CH3 )CH2 CH3 、OCF3 、OCH2 CF3 、CH2 OCH3 ，及CH(CH3 )OCH3 ；以及(K) R16 及R17 與Cx (Q2 )(Nx ) 一起，係選自於下列所構成的群組： (1i) 及 (1j) ， 其中R18 及R19 各自為H。The numerator of claim 1, wherein: (A) Ar 1 is (1a) (1a) wherein: (1) X 1 is selected from the group consisting of N and C R 1 , and (2) R 1 , R 2 , R 3 , R 4 and R 5 are each independently selected from The following groups are composed: H, Cl, CF 3 and OCF 3 ; (B) Het is (1b) (1b) , wherein R 6 is H; (C) L 1 is selected from the group consisting of: (1c) , (1d) , and (1e) wherein each R 7 , R 8 , R 9 and R 10 are independently selected from the group consisting of H and CH 3 ; (D) Ar 2 is (1f) (1f) wherein: (1) X 2 is selected from the group consisting of N and C R 13 , and (2) R 11 , R 12 , R 13 and R 14 are each independently selected from the following Groups: H, F, Cl, CH 3 , CF 3 , OCH 3 , and C(O)O-CH 3 ; (E) R 15 is H; (F) Q 1 is O; (G) Q 2 Is S; (H) R 16 is (K) ; (I) R 17 is (K) ; (J) L 2 is selected from the group consisting of: (1g) and (1h) wherein R 20 , R 21 , R 22 , R 23 and R 24 are each independently selected from the group consisting of H, F, Cl, CH 3 , CH 2 CH 2 CH 3 , CH (CH 3 ) 2 , CF 3 , cyclopropyl, OCH 3 , OCH 2 CH 3 , OCH(CH 3 ) 2 , OC(CH 3 ) 3 , OCH(CH 3 )CH 2 CH 3 , OCF 3 , OCH 2 CF 3 , CH 2 OCH 3 , and CH(CH 3 )OCH 3 ; and (K) R 16 and R 17 together with C x (Q 2 )(N x ) are selected from the group consisting of: (1i) and (1j) , wherein each of R 18 and R 19 is H. 如請求項1之分子，其中該分子為 The molecule of claim 1, wherein the molecule is 一種殺蟲組成物，其包含如請求項1、2、3、4及5中任一項之分子，其進一步包含一活性成分。A pesticidal composition comprising the molecule of any one of claims 1, 2, 3, 4 and 5, further comprising an active ingredient. 一種控制害蟲的方法，該方法包含將殺蟲有效量的如請求項1、2、3、4及5中任一項之分子施用至一所在地。A method of controlling pests, comprising administering a pesticidally effective amount of a molecule of any one of claims 1, 2, 3, 4 and 5 to a locus. 一種控制害蟲的方法，該方法包含將殺蟲有效量的如請求項6之殺蟲組成物施用至一所在地。A method of controlling pests, comprising applying a pesticidally effective amount of the pesticidal composition of claim 6 to a locus.
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