TW201612521A - Reagent and detection method by use of serum fetuin A as biomarkers for detecting hemolytic uremic and necrotizing pneumonia caused and infected by streptococcus pneumoniae - Google Patents

Reagent and detection method by use of serum fetuin A as biomarkers for detecting hemolytic uremic and necrotizing pneumonia caused and infected by streptococcus pneumoniae

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Publication number
TW201612521A
TW201612521A TW103131847A TW103131847A TW201612521A TW 201612521 A TW201612521 A TW 201612521A TW 103131847 A TW103131847 A TW 103131847A TW 103131847 A TW103131847 A TW 103131847A TW 201612521 A TW201612521 A TW 201612521A
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TW
Taiwan
Prior art keywords
streptococcus pneumoniae
serum
fetuin
infected
reagent
Prior art date
Application number
TW103131847A
Other languages
Chinese (zh)
Other versions
TWI536017B (en
Inventor
Zheng-Xun Qiu
Rajendra Prasad Janapatla
qi-liang Chen
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Chang Gung Medical Foundation
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Priority to TW103131847A priority Critical patent/TWI536017B/en
Publication of TW201612521A publication Critical patent/TW201612521A/en
Application granted granted Critical
Publication of TWI536017B publication Critical patent/TWI536017B/en

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Asialoglycoprotein that enriches the serum is called fetuin-A (that is also called [alpha] 2-Heremans-Schmid glycoprotein, or abbreviated as AHSG), which will be an attacked target by neuraminidase of streptococcus pneumoniae caused by severe streptococcus pneumoniae infection, so that the concentration level of fetuin-A of serum is significantly decreased. With the infection of streptococcus pneumoniae, we may qualitatively and quantitatively analyze the results of serum fetuin-A and other asialoglycoproteins, which can differentiate invasive pneumococcal diseases (abbreviated as IPD) from other pneumonia infection symptoms. According to the concentration level of serum fetuin-A, the present invention provides a kind of reagent and method as a basis to evaluate whether the severe invasive pneumococcal diseases are infected and attacked by streptococcus pneumoniae.
TW103131847A 2014-09-16 2014-09-16 Detection of hemolytic uremia by using serum fetuin A as a biomarker to detect streptococcus pneumoniae infection TWI536017B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW103131847A TWI536017B (en) 2014-09-16 2014-09-16 Detection of hemolytic uremia by using serum fetuin A as a biomarker to detect streptococcus pneumoniae infection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW103131847A TWI536017B (en) 2014-09-16 2014-09-16 Detection of hemolytic uremia by using serum fetuin A as a biomarker to detect streptococcus pneumoniae infection

Publications (2)

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TW201612521A true TW201612521A (en) 2016-04-01
TWI536017B TWI536017B (en) 2016-06-01

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TW103131847A TWI536017B (en) 2014-09-16 2014-09-16 Detection of hemolytic uremia by using serum fetuin A as a biomarker to detect streptococcus pneumoniae infection

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TWI536017B (en) 2016-06-01

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