TW201527297A - 前列腺素ｅｐ３受體之拮抗劑 - Google Patents

Info

Publication number

TW201527297A

TW201527297A TW103134754A TW103134754A TW201527297A TW 201527297 A TW201527297 A TW 201527297A TW 103134754 A TW103134754 A TW 103134754A TW 103134754 A TW103134754 A TW 103134754A TW 201527297 A TW201527297 A TW 201527297A

Authority

TW

Taiwan

Prior art keywords

compound

methyl

pharmaceutically acceptable

mmol

acceptable salt

Prior art date

2013-10-09

Links

• Espacenet
• Global Dossier
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• 101150053131 PTGER3 gene Proteins 0.000 title abstract description 8
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• 238000000034 method Methods 0.000 claims abstract description 46
• 241000124008 Mammalia Species 0.000 claims abstract description 14
• 150000001875 compounds Chemical class 0.000 claims description 190
• 150000003839 salts Chemical class 0.000 claims description 70
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 23
• 125000000217 alkyl group Chemical group 0.000 claims description 19
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• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 11
• 229910052731 fluorine Inorganic materials 0.000 claims description 11
• 239000008194 pharmaceutical composition Substances 0.000 claims description 11
• 229910052739 hydrogen Inorganic materials 0.000 claims description 10
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 9
• 208000007536 Thrombosis Diseases 0.000 claims description 9
• WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 claims description 9
• 208000029078 coronary artery disease Diseases 0.000 claims description 8
• 206010020772 Hypertension Diseases 0.000 claims description 7
• 229910052799 carbon Inorganic materials 0.000 claims description 7
• 206010020853 Hypertonic bladder Diseases 0.000 claims description 6
• 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 6
• 208000002193 Pain Diseases 0.000 claims description 6
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• 230000003914 insulin secretion Effects 0.000 claims description 6
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• 229910052736 halogen Inorganic materials 0.000 claims description 5
• 150000002367 halogens Chemical class 0.000 claims description 5
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• 206010036595 Premature delivery Diseases 0.000 claims description 2
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• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 142
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• 239000000203 mixture Substances 0.000 description 69
• 235000019439 ethyl acetate Nutrition 0.000 description 68
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 57
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• 239000000243 solution Substances 0.000 description 41
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• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 37
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 36
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• NXQGGXCHGDYOHB-UHFFFAOYSA-L cyclopenta-1,4-dien-1-yl(diphenyl)phosphane;dichloropalladium;iron(2+) Chemical compound [Fe+2].Cl[Pd]Cl.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 NXQGGXCHGDYOHB-UHFFFAOYSA-L 0.000 description 14
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• 239000013078 crystal Substances 0.000 description 12
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• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
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