TW201444530A - Method and device for determining disease and assessing therapeutic effect of disease according to blood flow sound - Google Patents

Method and device for determining disease and assessing therapeutic effect of disease according to blood flow sound Download PDF

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TW201444530A
TW201444530A TW102118691A TW102118691A TW201444530A TW 201444530 A TW201444530 A TW 201444530A TW 102118691 A TW102118691 A TW 102118691A TW 102118691 A TW102118691 A TW 102118691A TW 201444530 A TW201444530 A TW 201444530A
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spectrogram
blood flow
dimensional
disease
signal
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TWI498099B (en
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Po-Hsun Sung
Jieh-Neng Wang
Chung-Dann Kan
wei-ling Chen
Jhing-Fa Wang
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Nat Cheng Kung University Hospital
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Abstract

The present invention relates to a method and a device for determining disease and assessing therapeutic effect of disease according to blood flow sound, which may solve the problem of conventional physiological signal detection for converting the signals into two-dimensional spectrum for comparison and determination which likely caused errors. The present invention focuses on the determination and assessment of diseases affecting the blood flow, and includes the following steps: first, capturing a sound signal at a testing portion of a person under test for blood flowing in his body; performing the auditory-based cochlear transform on the sound signal to become a visualized cochlear spectrogram; and, comparing the cochlear spectrogram with a cochlear spectrogram data to determine if the testing portion of the person under test is suffered from related diseases, such as heart or cardiovascular disease, neonate's patent ductus arteriosus (PDA) or dialysis fistula narrowing. Furthermore, the envelope of sub-bands in the cochlear spectrogram of the patient before and after treatment can be extracted for assessing the therapeutic effect according to noise reduction status of the envelope after treatment. The present invention utilizes the visualized cochlear spectrogram established through the auditory-based cochlear transform as the basis for comparison to achieve higher determination accuracy.

Description

根據血流聲音判斷疾病與評估疾病治療效果之方法與裝置Method and device for judging disease and evaluating disease treatment effect according to blood flow sound

  本發明係有關於一種根據血流聲音判斷疾病與評估疾病治療效果之方法與裝置,特別是指將血流的聲音訊號利用人耳聽覺模型轉換(auditory-based cochlear transform)成為三維頻譜圖(cochlear spectrogram),用以作為比對判斷疾病以及評估治療效果之方法與裝置。The present invention relates to a method and apparatus for judging a disease according to blood flow sounds and evaluating the therapeutic effect of the disease, in particular, the sound signal of the blood flow is converted into a three-dimensional spectrogram by using an auditory-based cochlear transform (cochlear). Spectrogram), used as a method and device for comparing diseases and evaluating treatment effects.

  心臟的收縮、血管的窄化或硬化、血液的濃度、血脂的含量等等現象都會造成血液在流動時,有不同的生理訊號反應,例如電訊號或聲音訊號。因此根據血流的生理訊號來比對判斷,是目前常常用來觀察人體是否罹患相關疾病的方法。The contraction of the heart, the narrowing or hardening of the blood vessels, the concentration of blood, the content of blood lipids, etc., can cause different physiological signal reactions, such as electrical signals or sound signals, when the blood flows. Therefore, it is often used to observe whether the human body is suffering from related diseases according to the physiological signals of blood flow.

  例如美國專利US7485094「Methods of diagnosis using pulse volume measurement」,該案揭露利用量測脈搏強度來作為診斷的方法,可用以診斷失血狀態(blood loss)、新生兒開放性動脈導管閉鎖不全(patent ductus arteriosus, PDA)、心因性休克(cardiogenic shock)等現象。惟詳閱該案說明書,是採用時間-脈搏強度二維頻譜來作為分析的依據,而單從二維頻譜的分析有時會有過於簡化而誤差較大的情況;並且實際上在量測過程中,前述方式會由於外界雜訊或人體其他震顫等雜訊的干擾,造成分析上產生錯誤,因此在擷取生理訊號後,通常會使用濾波器來將雜訊濾除。For example, U.S. Patent No. 7,485,094, "Methods of diagnosis using pulse volume measurement", which discloses the use of measured pulse intensity as a diagnostic method for diagnosing blood loss, neonatal open arterial insufficiency (patent ductus arteriosus) , PDA), cardiogenic shock and other phenomena. However, the detailed description of the case is based on the time-pulse intensity two-dimensional spectrum as the basis for analysis, and the analysis from the two-dimensional spectrum sometimes has too much simplification and large error; and actually in the measurement process In the above method, due to the interference of external noise or other tremors of the human body, the analysis may cause errors. Therefore, after the physiological signal is extracted, a filter is usually used to filter the noise.

  而考量有些微小雜訊不易濾除,在中華民國發明專利公開第201244691號「心音/心臟疾病風險之判別系統及其方法」,提出利用『對心音訊號進行基於心音訊號的絕對值取自然對數後所得數值與心音訊號之乘積之特殊函數運算』的技術特徵,來濾除不易被濾掉的微小雜訊。該案揭露使用聲音訊號來比對分析,並提供了濾除微小雜訊的方法,惟該案雖提供濾除雜訊之技術特徵,但仍然是使用時間-頻率的二維頻譜來作為分析的依據,而依然存在可能過於簡化而會有誤差的情況。Considering that some small noises are not easy to filter out, in the Republic of China Invention Patent Disclosure No. 201244691 "Diagnosing System and Method of Heart Sound/Heart Disease Risk", it is proposed to use "the natural sound logarithm of the heart sound signal based on the absolute value of the heart sound signal". The technical characteristics of the special function operation of the product of the obtained value and the heart sound signal filter out the small noise that is not easily filtered out. The case reveals the use of sound signals for comparison analysis and provides a means of filtering out small noise. However, although the case provides technical features for filtering noise, it still uses time-frequency two-dimensional spectrum for analysis. Based on the facts, there may still be cases where the calculation may be too simplified and there may be errors.

  再審閱既有訊號分析技術,西元2009年QiLi等人利用下述小波理論,採用模仿人類聽覺特性的基底Ψa,b來分析聲音訊號:
Reviewing the existing signal analysis techniques, in 2009, QiLi et al. used the following wavelet theory to analyze the sound signals using the bases a, b that mimic human hearing characteristics:

  藉此可以根據人類聽覺特性,直覺式的判斷分析所取得的聲音訊號的特質。In this way, the characteristics of the obtained sound signal can be analyzed based on the human auditory characteristics and the intuitive judgment.

  爰此,基於將聲音訊號轉換為類似人耳聽覺特性的頻譜來分析的方便性。本發明提出一種根據血流聲音判斷疾病之方法,是一種將血流聲音訊號轉換為三維頻譜做為分析比對的方法,並且是利用人耳聽覺模型轉換(auditory-based cochlear transform)而將聲音直覺的轉換為視覺化的三維頻譜圖(cochlear spectrogram),而能夠做直覺性的分析判斷,可用以判斷例如受測者是否罹患心臟或心血管疾病、受測者之洗腎瘻管是否窄化或受測者為新生兒時,新生兒之心臟與肺臟之間的瘻管是否關閉等各種疾病。Thus, the convenience of analysis based on the conversion of sound signals into a spectrum similar to human auditory characteristics. The invention provides a method for judging a disease according to a blood flow sound, which is a method for converting a blood flow sound signal into a three-dimensional spectrum as an analytical comparison, and using an auditory-based cochlear transform to sound Intuitive conversion to a visual cochlear spectrogram, and the ability to make intuitive analytical judgments, can be used to determine, for example, whether the subject is suffering from heart or cardiovascular disease, whether the subject's dialysis catheter is narrowed or When the subject is a newborn, various diseases such as whether the fistula between the heart and the lung of the newborn is closed.

  本發明前述方法包括有下列步驟:The foregoing method of the present invention includes the following steps:

  A.對一受測者之一受測部位,擷取其體內血液流動的一聲音訊號;B.將前述聲音訊號透過一人耳聽覺模型轉換(auditory-based cochlear transform),成為一三維頻譜圖(cochlear spectrogram);C.比對該三維頻譜圖與一三維頻譜資料,該三維頻譜資料包括有:在正常狀態下,血液流動產生的三維頻譜圖,以及在多種影響血流之疾病的狀態下,血液流動產生的三維頻譜圖,藉以判斷該受測者之受測部位是否為健康狀態或罹患前述疾病。A. A sound signal of blood flow in one of the tested subjects; B. The above-mentioned sound signal is converted into a three-dimensional spectrogram through an auditory-based cochlear transform ( Cochlear spectrogram); C. Comparing the three-dimensional spectrogram with a three-dimensional spectral data, the three-dimensional spectral data includes: a three-dimensional spectrogram generated by blood flow under normal conditions, and in a state of various diseases affecting blood flow, A three-dimensional spectrogram generated by blood flow to determine whether the subject's tested site is in a healthy state or suffers from the aforementioned disease.

  在步驟B所述之人耳聽覺模型轉換 (auditory-based cochlear transform)係採用:The auditory-based cochlear transform described in step B uses:

  其中,CS(a,b)代表人耳聽覺模型轉換之輸出,a代表每一頻帶之中心頻率相對於最低頻帶之中心頻率之比值倒數,b代表不同時間位置,s(t)代表所取樣的單一聲波訊號其時間函數,Ψ* a,b為所選用之小波基底模型函數,本發明使用的基底Ψ* a,b不同於QiLi等人提出之基底,是結合日本人T. Irino等人於“A dynamic compressive gammachirp auditory filterbank,”IEEETrans. Audio, Speech, Language Prcess., vol.14,pp.2222-2232, Nov.2006.所提出之基底。Where CS(a,b) represents the output of the human auditory model transformation, a represents the inverse of the ratio of the center frequency of each frequency band to the center frequency of the lowest frequency band, b represents different time positions, and s(t) represents the sampled The time function of a single acoustic signal, Ψ * a, b is the selected wavelet base model function. The substrate Ψ * a, b used in the present invention is different from the substrate proposed by QiLi et al., and is combined with Japanese T. Irino et al. "A dynamic compressive gammachirp auditory filterbank," IEEE Trans. Audio, Speech, Language Prcess., vol. 14, pp. 2222-2232, Nov. 2006.

  根據前述運算結果所得到三維頻譜圖包括有時間、頻率及相關性強度三個維度,前述步驟C至少根據下列二者進行比對:時間-頻率二維頻譜、時間-相關性強度二維頻譜及頻率-相關性強度二維頻譜。The three-dimensional spectrogram obtained according to the foregoing operation result includes three dimensions of time, frequency and correlation strength, and the foregoing step C is compared according to at least two of the following: time-frequency two-dimensional spectrum, time-correlation intensity two-dimensional spectrum and Frequency-correlation intensity two-dimensional spectrum.

  再者,亦可進一步擷取步驟B的三維頻譜圖中的次頻段的包絡面(extraction the envelop of sub-band signal of cochlear spectrogram),可將其稱作時域相關性頻譜圖(temporal correlogram),步驟C的三維頻譜資料則包括有依據各三維頻譜圖取得的時域相關性頻譜圖,再執行比對程序。而前述時域相關性頻譜圖計算採用:Furthermore, the envelop the sub-band signal of cochlear spectrogram in the three-dimensional spectrogram of step B may be further extracted, which may be referred to as a temporal correlogram. The three-dimensional spectrum data of step C includes a time domain correlation spectrum map obtained according to each three-dimensional spectrogram, and then the comparison program is executed. The aforementioned time domain correlation spectrum map is calculated by:

  其中,m代表的是前述人耳聽覺模型轉換中的CS(a,b)分別在頻帶k,時間n時的三維頻譜圖的包絡線,w代表的是取樣點長度為l的窗函數(window),τ代表的是移動多少訊號取樣點,可根據不同的使用需求選擇不同的窗函數,本發明所使用的窗函數為漢明窗(Hamming Window)。Where m represents the envelope of the three-dimensional spectrogram of CS(a,b) in the above-mentioned human auditory model conversion at frequency band k and time n, respectively, and w represents a window function with a sampling point length of l (window) ), τ represents how many signal sampling points are moved, and different window functions can be selected according to different usage requirements. The window function used in the present invention is a Hamming Window.

  進一步,可透過多點式的量測以找出共同點,而排除異常狀態。因此在步驟A中,係擷取該受測部位複數個不同位置的聲音訊號,而在步驟C係將該複數個聲音訊號產生的複數個三維頻譜圖與該三維頻譜資料比對,並且取該複數個三維頻譜圖之判斷結果中,有最多個相同者作為最終判斷結果。Further, the multi-point measurement can be used to find common points and exclude abnormal states. Therefore, in step A, the sound signals of the plurality of different positions of the tested portion are captured, and in step C, the plurality of three-dimensional spectrograms generated by the plurality of sound signals are compared with the three-dimensional spectral data, and the Among the judgment results of the plurality of three-dimensional spectrograms, the most identical ones are the final judgment results.

  本發明再提供一種根據血流聲音評估疾病治療效果之方法,主要是因為例如具有血管疾病的患者在施行血管擴張術或其他治療方式後,利用前述方法取得的三維頻譜圖會趨於正常型態,醫師無法準確的從前述三維頻譜圖來判斷血管疾病患者的術後復原期的復原狀況,必須要利用其他方式來輔助評估;本發明則利用取得前述三維頻譜圖的次頻段的包絡面,即前述的時域相關性頻譜圖,來放大細微的雜訊,供醫師作為評估患者的術後復原期的復原狀況之依據。The present invention further provides a method for assessing the therapeutic effect of a disease according to blood flow sounds, mainly because, for example, a patient having a vascular disease undergoes a vasodilation or other treatment mode, and the three-dimensional spectrogram obtained by the aforementioned method tends to be in a normal form. The physician cannot accurately determine the recovery status of the postoperative recovery period of the vascular disease patient from the aforementioned three-dimensional spectrogram, and must use other methods to assist the evaluation; the present invention utilizes the envelope surface of the sub-band obtained by obtaining the aforementioned three-dimensional spectrogram, that is, The aforementioned time domain correlation spectrogram is used to amplify subtle noise for the physician to use as a basis for assessing the patient's recovery from postoperative recovery.

  本發明前述方法包括下列步驟:The aforementioned method of the present invention comprises the following steps:

  A.對罹患有影響血流之疾病的一受測者,擷取該受測者罹患有前述疾病之一受測部位在治療前及治療後,其血液在該受測部位體內流動的一聲音訊號;B.將前述聲音訊號透過一人耳聽覺模型轉換(auditory-based cochlear transform),成為一治療前三維頻譜圖(pre-cochlear spectrogram)及一治療後三維頻譜圖(post-cochlear spectrogram);C.擷取前述治療前三維頻譜圖及治療後三維頻譜圖中的次頻段的包絡面(extraction the envelop of sub-band signal of cochlear spectrogram),將其定義為時域相關性頻譜圖(temporal correlogram);D.比對治療前的時域相關性頻譜圖與治療後的時域相關性頻譜圖,根據治療後的時域相關性頻譜圖之雜訊減少結果來評估治療效果。其中前述時域相關性頻譜圖包含有時間、頻率及關聯度係數(correlation coefficient)三個維度,係擷取治療前的時域相關性頻譜圖及治療後的時域相關性頻譜圖的一主頻波峰其頻率的包絡線進行比對。A. For a subject suffering from a disease affecting blood flow, the subject is subjected to a sound of blood flowing in the body to be tested before and after treatment of one of the aforementioned diseases. The signal is transmitted through an auditory-based cochlear transform into a pre-cochlear spectrogram and a post-cochlear spectrogram; Extract the envelop of sub-band signal of cochlear spectrogram and define the temporal correlogram D. Compare the time domain correlation spectrum map before treatment with the time domain correlation spectrum map after treatment, and evaluate the treatment effect according to the noise reduction result of the time domain correlation spectrum map after treatment. The aforementioned time domain correlation spectrogram includes three dimensions of time, frequency and correlation coefficient, and takes the time domain correlation spectrum map before treatment and the main domain of the time domain correlation spectrum map after treatment. The peaks of the frequency peaks are compared by the envelope of their frequencies.

  本發明進一步再提供一種裝置,用以執行前述方法,包括有:一訊號接收單元;一訊號處理模組,包括有一訊號轉換單元電性連接該訊號接收單元,以及有一輸出單元電性連接該訊號轉換單元;一圖形辨識模組,包括有一資料庫及一比對單元,該比對單元電性連接該輸出單元。The present invention further provides a device for performing the foregoing method, including: a signal receiving unit; a signal processing module including a signal conversion unit electrically connected to the signal receiving unit, and an output unit electrically connecting the signal The conversion unit includes a data library and a comparison unit, and the comparison unit is electrically connected to the output unit.

  由該訊號接收單元接收前述聲音訊號,再由該訊號轉換單元將該聲音訊號轉換為前述三維頻譜圖,或者進一步再擷取前述三維頻譜圖的中的次頻段的包絡面(extraction the envelop of sub-band signal of cochlear spectrogram),再由該輸出單元輸出。前述資料庫則儲存有前述三維頻譜資料,或者進一步儲存病患治療前的時域相關性頻譜圖。如此可用以執行後續比對程序,來判斷前述受測者是否罹患相關疾病,或評估受測者之術後復原狀況。The signal receiving unit receives the sound signal, and the signal converting unit converts the sound signal into the three-dimensional spectrogram, or further extracts an envelope of the sub-band in the three-dimensional spectrogram (extraction the envelop of sub -band signal of cochlear spectrogram), which is then output by the output unit. The aforementioned database stores the aforementioned three-dimensional spectrum data, or further stores the time domain correlation spectrum map of the patient before treatment. This can be used to perform a subsequent comparison procedure to determine whether the subject is suffering from a related disease or to assess the postoperative recovery of the subject.

  本發明具有下列功效:The invention has the following effects:

  1.利用人耳聽覺模型轉換(auditory-based cochlear transform)建立視覺化的三維頻譜圖(cochlear spectrogram),將聽覺透過視覺化的分析,來達到類似聽診(auscultation)的效果。1. Use the auditory-based cochlear transform to create a visual cochlear spectrogram, and visually analyze the auditory to achieve a similar auscultation effect.

  2.本發明使用三維頻譜圖的分析判斷,其中至少使用二個二維頻譜的比對,判斷準確率較高。2. The present invention uses the analysis and judgment of the three-dimensional spectrogram, wherein at least two pairs of two-dimensional spectra are used for comparison, and the judgment accuracy is high.

  3.本發明將患者治療前及治療後,利用其血液流動的三維頻譜圖來擷取時域相關性頻譜圖,放大輕微的雜訊,供醫師可根據治療後包絡面的雜訊減少狀態來評估治療效果。3. The present invention uses a three-dimensional spectrogram of blood flow before and after treatment to obtain a time-domain correlation spectrum map, and amplifies slight noise for the physician to reduce the state of the noise according to the envelope surface after treatment. Assess the treatment effect.

(1)...訊號接收單元(1). . . Signal receiving unit

(2)...訊號處理模組(2). . . Signal processing module

(21)...訊號轉換單元(twenty one). . . Signal conversion unit

(22)...輸出單元(twenty two). . . Output unit

(3)...圖形辨識模組(3). . . Graphic recognition module

(31)...資料庫(31). . . database

(32)...比對單元(32). . . Alignment unit

  第一圖係為本發明第一實施例之系統架構圖。
  第二A圖係為本發明第一實施例中,新生兒出生後心臟與肺臟之間的瘻管正常關閉下,三維頻譜圖具有明顯的週期性。
  第二B圖係為本發明第一實施例中,新生兒出生後心臟與肺臟之間的瘻管沒有正常關閉(PDA),三維頻譜圖每一個週期之間具有連續性的雜訊。
  第三圖係為本發明第一實施例之流程圖。
  第四A圖係為本發明第二實施例中,新生兒出生後心臟與肺臟之間的瘻管正常關閉下,其時域相關性頻譜圖具有明顯的週期性。
  第四B圖係為本發明第二實施例中,新生兒出生後心臟與肺臟之間的瘻管沒有正常關閉(PDA),其時域相關性頻譜圖每一個週期之間具有連續性的雜訊。
  第五圖係為本發明第三實施例之流程圖。
  第六A圖係為受測者治療前量測的時域相關性頻譜圖。
  第六B圖係為受測者治療後量測的時域相關性頻譜圖。
  第七A圖係為擷取第六A圖中主頻波峰的頻率的包絡線圖。
  第七B圖係為擷取第六B圖中主頻波峰的頻率的包絡線圖。
The first figure is a system architecture diagram of the first embodiment of the present invention.
The second A diagram is the first embodiment of the present invention, and the three-dimensional spectrogram has obvious periodicity under normal closure of the fistula between the heart and the lung after birth.
The second B diagram is the first embodiment of the present invention, in which the fistula between the heart and the lungs after birth is not normally closed (PDA), and the three-dimensional spectrogram has continuous noise between each cycle.
The third figure is a flow chart of the first embodiment of the present invention.
The fourth A diagram is the second embodiment of the present invention, and the time domain correlation spectrum map has obvious periodicity under the normal closure of the fistula between the heart and the lung after the birth of the newborn.
The fourth B is a second embodiment of the present invention, in which the fistula between the heart and the lungs is not normally closed (PDA) after birth, and the time domain correlation spectrum map has continuous noise between each cycle. .
The fifth drawing is a flow chart of the third embodiment of the present invention.
Figure 6A is a time-domain correlation spectrum of the pre-treatment measurement of the subject.
Figure 6B is a time-domain correlation spectrum of the subject's post-treatment measurements.
The seventh picture A is an envelope diagram of the frequency of the main frequency peak in the sixth A picture.
The seventh B diagram is an envelope diagram of the frequency of the main frequency peak in the sixth B diagram.

  本發明第一實施例係為一種根據血流聲音判斷疾病之方法及裝置。請參閱第一圖所示,為本發明第一實施例的裝置示意圖,包括有:The first embodiment of the present invention is a method and apparatus for determining a disease based on blood flow sounds. Referring to the first figure, a schematic diagram of a device according to a first embodiment of the present invention includes:

  一訊號接收單元(1)、一訊號處理模組(2)以及一圖形辨識模組(3)。其中該訊號處理模組(2)包括有一訊號轉換單元(21)及一輸出單元(22);該圖形辨識模組(3)包括有一資料庫(31)及一比對單元(32),該資料庫(31)儲存有各種狀態下血液在人體內流動的聲音訊號經過人耳聽覺模型轉換(auditory-based cochlear transform)而建立的三維頻譜資料:包括有正常狀態下血液流動產生的三維頻譜圖,以及多種會影響血流之相關疾病的狀態下血液流動產生的三維頻譜圖。A signal receiving unit (1), a signal processing module (2) and a graphic recognition module (3). The signal processing module (2) includes a signal conversion unit (21) and an output unit (22); the graphic recognition module (3) includes a data library (31) and a comparison unit (32). The database (31) stores three-dimensional spectral data established by an audio-based cochlear transform of sound signals flowing in the human body in various states: including a three-dimensional spectrogram generated by blood flow under normal conditions. And a three-dimensional spectrogram of blood flow produced by various conditions that affect blood flow related diseases.

  其中前述人耳聽覺模型轉換可將前述血液流動的聲音訊號直覺式的轉換為視覺模型的三維頻譜圖。所述人耳聽覺模型轉換採用:The aforementioned human auditory model transformation can intuitively convert the sound signal of the blood flow into a three-dimensional spectrogram of the visual model. The human ear auditory model is converted using:





  其中,CS(a,b)代表人耳聽覺模型轉換之輸出,a代表每一頻帶之中心頻率相對於最低頻帶之中心頻率之比值倒數,b代表不同時間位置,s(t)代表所取樣的單一聲波訊號其時間函數,Ψ* a,b為所選用之小波基底模型函數,本發明使用的基底Ψ* a,b不同於QiLi等人提出之基底,是結合日本人T. Irino等人於“A dynamic compressive gammachirp auditory filterbank,”IEEETrans. Audio, Speech, Language Prcess., vol.14,pp.2222-2232, Nov.2006.所提出之基底。Where CS(a,b) represents the output of the human auditory model transformation, a represents the inverse of the ratio of the center frequency of each frequency band to the center frequency of the lowest frequency band, b represents different time positions, and s(t) represents the sampled The time function of a single acoustic signal, Ψ * a, b is the selected wavelet base model function. The substrate Ψ * a, b used in the present invention is different from the substrate proposed by QiLi et al., and is combined with Japanese T. Irino et al. "A dynamic compressive gammachirp auditory filterbank," IEEE Trans. Audio, Speech, Language Prcess., vol. 14, pp. 2222-2232, Nov. 2006.

  前述公式轉換的三維頻譜圖包括有時間、頻率及相關性強度三個維度。The three-dimensional spectrogram converted by the above formula includes three dimensions of time, frequency and correlation strength.

  參閱第二A圖,是量測新生兒出生後正常狀態下,連接在心臟與肺臟之間的瘻管正常關閉後血液在心臟大動脈流動的聲音訊號。由於心臟是週期性的收縮而給予血液動力,使血液能在人體進行循環,因此當前述瘻管正常關閉後,可以發現血液在心臟大動脈流動的聲音訊號經過轉換為三維頻譜圖後具有明顯的週期性;參閱第二B圖,當前述瘻管沒有正常關閉時,由於血液在大動脈流動與在肺動脈流動時具有壓力差,因此部分血液會經由前述瘻管而自大動脈流往肺動脈,此即開放性動脈導管閉鎖不全(patent ductus arteriosus, PDA)的症狀,量測聲音訊號時則會在心臟收縮的每一個週期之間產生連續性的心雜音,使得聲音訊號經過轉換為三維頻譜圖後不具有明顯的週期性。Referring to Figure 2A, it is a measure of the flow of blood in the aorta of the heart after normal closure of the neonate after birth, after the normal closure of the fistula between the heart and the lung. Since the heart is periodically contracted to give blood power, so that the blood can circulate in the human body. Therefore, when the fistula is normally closed, it can be found that the sound signal of blood flowing in the cardiac aorta has obvious periodicity after being converted into a three-dimensional spectrogram. Referring to the second B diagram, when the fistula is not normally closed, due to the pressure difference between the flow of blood in the aorta and the flow of the pulmonary artery, part of the blood flows from the aorta to the pulmonary artery via the fistula, which is an open arterial atresia. In the case of incomplete (patent ductus arteriosus, PDA), when measuring the sound signal, a continuous heart murmur is generated between each cycle of the heart contraction, so that the sound signal does not have obvious periodicity after being converted into a three-dimensional spectrogram. .

  再請參閱第三圖所示,本實施例包括有下列步驟:Referring to the third figure, the embodiment includes the following steps:

  A.利用前述訊號接收單元(1),例如聽診器,擷取新生兒其血液在心臟大動脈內流動的一聲音訊號。A. Using the aforementioned signal receiving unit (1), such as a stethoscope, to capture an audible signal that the newborn's blood flows in the aorta of the heart.

  B.該訊號接收單元(1)會將該聲音訊號輸入至該訊號處理模組(2)的訊號轉換單元(21)中,該訊號轉換單元(21)接收到該聲音訊號後會透過前述人耳聽覺模型轉換,而將該聲音訊號轉換為一三維頻譜圖。B. The signal receiving unit (1) inputs the audio signal into the signal conversion unit (21) of the signal processing module (2), and the signal conversion unit (21) receives the voice signal and transmits the voice through the person The ear hearing model is converted and the sound signal is converted into a three-dimensional spectrogram.

  C.該三維頻譜圖被輸入至該圖形辨識模組(3)的比對單元(32)中,該比對單元(32)將該三維頻譜圖與前述資料庫(31)內的三維頻譜資料進行比對,而輸出判斷結果。其中一種比對方式是至少根據下列二者進行比對:時間-頻率二維頻譜、時間-相關性強度二維頻譜及頻率-相關性強度二維頻譜。而將聽覺透過視覺化的分析比對,具有類似聽診(auscultation)的效果,可藉以判斷該新生兒是否罹患有開放性動脈導管閉鎖不全(patent ductus arteriosus, PDA)的症狀。C. The three-dimensional spectrogram is input into a comparison unit (32) of the pattern recognition module (3), and the comparison unit (32) compares the three-dimensional spectrogram with the three-dimensional spectrum data in the database (31) The comparison is performed, and the judgment result is output. One of the comparison methods is based on at least two comparisons: time-frequency two-dimensional spectrum, time-correlation intensity two-dimensional spectrum, and frequency-correlation intensity two-dimensional spectrum. By comparing the auditory analysis through visualization, it has the effect of auscultation, which can be used to determine whether the newborn has symptoms of open ductus arteriosus (PDA).

  進一步要說明的是,在操作時可透過多點式的量測以找出共同點,而排除異常狀態,因此在步驟A中,可以擷取前述新生兒大動脈不同位置處的聲音訊號,而在步驟C中比對該複數個聲音訊號產生的複數個三維頻譜圖,並且取該複數個三維頻譜圖之判斷結果中,有最多個相同者作為最終判斷結果,準確度更高。It should be further noted that in the operation, the multi-point measurement can be used to find the common point, and the abnormal state is excluded, so in step A, the sound signals at different positions of the neonatal aorta can be retrieved, and In the step C, a plurality of three-dimensional spectrograms generated by the plurality of audio signals are obtained, and among the determination results of the plurality of three-dimensional spectrograms, the most identical ones are used as the final judgment result, and the accuracy is higher.

  除了上述用以分析比對新生兒的開放性動脈導管閉鎖不全(patent ductus arteriosus, PDA)的症狀之外,尚可用於判斷受測者是否具有其他心臟血管疾病,或用以判斷受測者之洗腎瘻管是否窄化等各種血管疾病。In addition to the above-mentioned symptoms for analyzing the open ductus arteriosus (PDA) of the newborn, it can be used to determine whether the subject has other cardiovascular diseases or to judge the subject. Whether the dialysis tube is narrowed and other various vascular diseases.

  本發明第二實施例請參閱第四A圖及第四B圖所示,進一步擷取步驟B的三維頻譜圖中的次頻段的包絡面(extraction the envelop of sub-band signal of cochlear spectrogram),亦稱為時域相關性頻譜圖(temporal correlogram),前述資料庫(31)則儲存有依據各三維頻譜圖取得的時域相關性頻譜圖。For the second embodiment of the present invention, please refer to the fourth A picture and the fourth B picture, and further extract the envelop of sub-band signal of cochlear spectrogram in the three-dimensional spectrum diagram of step B, Also known as a temporal correlogram, the aforementioned database (31) stores a time domain correlation spectrogram obtained from each of the three-dimensional spectrograms.

  其中計算前述時域相關性頻譜圖(temporal correlogram)係採用:The calculation of the aforementioned temporal correlogram is carried out by:





  其中,m代表的是前述人耳聽覺模型轉換中的CS(a,b)分別在頻帶k,時間n時的三維頻譜圖的包絡線,w代表的是取樣點長度為l的窗函數(window),τ代表的是移動多少訊號取樣點,可根據不同的使用需求選擇不同的窗函數,本發明所使用的窗函數為漢明窗(Hamming Window)。Where m represents the envelope of the three-dimensional spectrogram of CS(a,b) in the above-mentioned human auditory model conversion at frequency band k and time n, respectively, and w represents a window function with a sampling point length of l (window) ), τ represents how many signal sampling points are moved, and different window functions can be selected according to different usage requirements. The window function used in the present invention is a Hamming Window.

  當新生兒連接在心臟與肺臟之間的瘻管正常關閉下,其時域相關性頻譜圖(temporal correlogram)亦具有明顯的週期性;當新生兒罹患有開放性動脈導管閉鎖不全(patent ductus arteriosus, PDA)的症狀時,其時域相關性頻譜圖(temporal correlogram)亦呈現不具有明顯的週期性。因此在步驟C亦可比對時域相關性頻譜圖(temporal correlogram)來作為判斷的依據。When the neonate is connected to the normal closure of the fistula between the heart and the lung, its temporal correlogram also has a pronounced periodicity; when the neonate has an open arterial insufficiency (patent ductus arteriosus, When the symptoms of PDA), the temporal correlogram also showed no significant periodicity. Therefore, in step C, the temporal correlogram can also be used as the basis for the judgment.

  本發明第三實施例請參閱第五圖及第六A圖、第六B圖所示,本實施例是一種根據血流聲音評估疾病治療效果之方法及裝置,其中本實施例之裝置與第一實施例相同,而在該資料庫(31)儲存有根據病患治療前所量測的三維頻譜圖取得的時域相關性頻譜圖(temporal correlogram),利用取得前述時域相關性頻譜圖(temporal correlogram)來放大細微的雜訊,因此可供醫師作為評估血管疾病患者的術後復原期的復原狀況之依據。前述時域相關性頻譜圖(temporal correlogram)包含有時間、頻率及關聯度係數(correlation coefficient)三個維度。The third embodiment of the present invention is shown in FIG. 5 and FIG. 6A and FIG. 6B. The embodiment is a method and a device for evaluating a disease treatment effect according to blood flow sound, wherein the device and the device of the embodiment In an embodiment, the time domain correlation spectrogram obtained by the three-dimensional spectrogram measured according to the patient's treatment is stored in the database (31), and the time domain correlation spectrum map is obtained by using the time domain correlation spectrum ( The temporal correlogram is used to amplify subtle noise, so it can be used as a basis for assessing the recovery of postoperative recovery in patients with vascular disease. The aforementioned temporal correlogram contains three dimensions of time, frequency and correlation coefficient.

  主要是例如當具有血管疾病的患者在施行血管擴張術或其他治療方式後,利用前述方法取得的三維頻譜圖會趨近於正常型態,醫師無法準確的從前述三維頻譜圖來判斷血管疾病患者的術後復原期的復原狀況,必須要利用其他方式來輔助評估。Mainly, for example, when a patient with vascular disease undergoes vasodilation or other treatment methods, the three-dimensional spectrogram obtained by the aforementioned method will approach the normal pattern, and the physician cannot accurately determine the patient with vascular disease from the aforementioned three-dimensional spectrogram. In the recovery of the postoperative recovery period, other methods must be used to assist the assessment.

  本實施例包括下列步驟:This embodiment includes the following steps:

  A.利用前述訊號接收單元(1)對一罹患有影響血流相關疾病的受測者,擷取治療前及治療後其血液流動的一聲音訊號。A. The above-mentioned signal receiving unit (1) is used to extract a sound signal of blood flow before and after treatment for a subject suffering from a blood flow related disease.

  B.將前述聲音訊號透過前述人耳聽覺模型轉換(auditory-based cochlear transform),成為一治療前三維頻譜圖(pre-cochlear spectrogram)及一治療後三維頻譜圖(post-cochlear spectrogram)。B. The aforementioned sound signal is transmitted through the aforementioned auditory-based cochlear transform into a pre-cochlear spectrogram and a post-cochlear spectrogram.

  C.擷取前述治療前三維頻譜圖及治療後三維頻譜圖中的次頻段的包絡面(extraction the envelop of sub-band signal of cochlear spectrogram),亦即前述時域相關性頻譜圖(temporal correlogram),如此可放大原來不易觀察的細微雜訊。C. extracting the aforementioned pre-treatment three-dimensional spectrogram and the extraction of the envelop of sub-band signal of cochlear spectrogram, that is, the aforementioned temporal correlogram This can enlarge the fine noise that was difficult to observe.

  D.比對治療前的時域相關性頻譜圖與治療後的時域相關性頻譜圖,根據治療後的時域相關性頻譜圖之雜訊減少結果來評估治療效果。D. Compare the time domain correlation spectrum map before treatment with the time domain correlation spectrum map after treatment, and evaluate the treatment effect according to the noise reduction result of the time domain correlation spectrum map after treatment.

  參閱第七A圖及第七B圖所示,進一步可擷取主頻波峰的頻率的包絡線進行比對。Referring to FIGS. 7A and 7B, the envelope of the frequency of the main frequency peak can be further compared.

  綜合上述實施例之說明,當可充分瞭解本發明之操作、使用及本發明產生之功效,惟以上所述實施例僅係為本發明之較佳實施例,當不能以此限定本發明實施之範圍,即依本發明申請專利範圍及發明說明內容所作簡單的等效變化與修飾,皆屬本發明涵蓋之範圍內。In view of the foregoing description of the embodiments, the operation and the use of the present invention and the effects of the present invention are fully understood, but the above described embodiments are merely preferred embodiments of the present invention, and the invention may not be limited thereto. Included within the scope of the present invention are the scope of the present invention.

no

Claims (17)

一種根據血流聲音判斷疾病之方法,包括下列步驟:
A.對一受測者之一受測部位,擷取其體內血液流動的一聲音訊號;
B.將前述聲音訊號透過一人耳聽覺模型轉換(auditory-based cochlear transform),成為一三維頻譜圖(cochlear spectrogram);
C.比對該三維頻譜圖與一三維頻譜資料,該三維頻譜資料包括有:在正常狀態下,血液流動產生的三維頻譜圖,以及在多種影響血流之疾病的狀態下,血液流動產生的三維頻譜圖,藉以判斷該受測者之受測部位是否為健康狀態或罹患前述疾病。
A method for judging a disease based on blood flow sounds, comprising the following steps:
A. A sound signal of blood flow in one of the tested subjects;
B. The above-mentioned sound signal is converted into a cochlear spectrogram through an auditory-based cochlear transform;
C. Comparing the three-dimensional spectrogram with a three-dimensional spectrum data, the three-dimensional spectrum data includes: a three-dimensional spectrogram generated by blood flow under normal conditions, and blood flow generated under various conditions affecting blood flow A three-dimensional spectrogram is used to determine whether the subject to be tested is in a healthy state or suffers from the aforementioned diseases.
如申請專利範圍第1項所述之根據血流聲音判斷疾病之方法,其中步驟B所述之人耳聽覺模型轉換 (auditory-based cochlear transform)係採用:


其中,CS(a,b)代表人耳聽覺模型轉換之輸出,a代表每一頻帶之中心頻率相對於最低頻帶之中心頻率之比值倒數,b代表不同時間位置,s(t)代表所取樣的單一聲波訊號其時間函數,Ψ* a,b為所選用之小波基底模型函數。
The method for judging a disease according to a blood flow sound according to the first aspect of the patent application, wherein the auditory-based cochlear transform described in the step B is:


Where CS(a,b) represents the output of the human auditory model transformation, a represents the inverse of the ratio of the center frequency of each frequency band to the center frequency of the lowest frequency band, b represents different time positions, and s(t) represents the sampled The time function of a single acoustic signal, Ψ * a, b is the selected wavelet base model function.
如申請專利範圍第2項所述之根據血流聲音判斷疾病之方法,其中前述三維頻譜圖包括有時間、頻率及相關性強度三個維度,前述步驟C至少根據下列二者進行比對:時間-頻率二維頻譜、時間-相關性強度二維頻譜及頻率-相關性強度二維頻譜。The method for judging a disease according to a blood flow sound according to the second aspect of the patent application, wherein the foregoing three-dimensional spectrogram includes three dimensions of time, frequency and correlation strength, and the foregoing step C is compared according to at least the following: time - Frequency two-dimensional spectrum, time-correlation intensity two-dimensional spectrum and frequency-correlation intensity two-dimensional spectrum. 如申請專利範圍第2項所述之根據血流聲音判斷疾病之方法,進一步擷取步驟B的三維頻譜圖中的次頻段的包絡面(extraction the envelop of sub-band signal of cochlear spectrogram),將其定義為時域相關性頻譜圖(temporal correlogram),步驟C的三維頻譜資料則包括有依據各三維頻譜圖取得的時域相關性頻譜圖,再執行比對程序。Extracting the envelop of sub-band signal of cochlear spectrogram in the three-dimensional spectrogram of step B, as described in the second aspect of the patent application, for determining the disease according to the blood flow sound It is defined as a temporal correlogram, and the three-dimensional spectrum data of step C includes a time domain correlation spectrogram obtained from each three-dimensional spectrogram, and then the comparison program is executed. 如申請專利範圍第4項所述之根據血流聲音判斷疾病之方法,其中計算前述時域相關性頻譜圖(temporal correlogram)係採用:


其中,m代表的是前述人耳聽覺模型轉換中的CS(a,b)分別在頻帶k,時間n時的三維頻譜圖的包絡線,w代表的是取樣點長度為l的窗函數(window),τ代表的是移動多少訊號取樣點。
The method for determining a disease according to blood flow sounds as described in claim 4, wherein calculating the aforementioned temporal correlogram is performed by:


Where m represents the envelope of the three-dimensional spectrogram of CS(a,b) in the above-mentioned human auditory model conversion at frequency band k and time n, respectively, and w represents a window function with a sampling point length of l (window) ), τ represents how many signal sampling points are moved.
如申請專利範圍第1項所述之根據血流聲音判斷疾病之方法,在步驟A中,係擷取該受測部位複數個不同位置的聲音訊號,而在步驟C係將該複數個聲音訊號產生的複數個三維頻譜圖與該三維頻譜資料比對,並且取該複數個三維頻譜圖之判斷結果中,有最多個相同者作為最終判斷結果。In the method of determining the disease according to the blood flow sound according to the first aspect of the patent application, in step A, the sound signals of the plurality of different positions of the tested part are captured, and in step C, the plurality of sound signals are obtained. The generated plurality of three-dimensional spectrograms are compared with the three-dimensional spectrum data, and among the determination results of the plurality of three-dimensional spectrograms, the most plurality of identical persons are used as the final judgment result. 如申請專利範圍第1項所述之根據血流聲音判斷疾病之方法,在步驟A中,該受測者之受測部位為心臟或心血管,係量測該受測者其血液在心臟或心血管內流動的聲音訊號,藉以在步驟C判斷該受測者是否具有心臟或心血管疾病。In the method of determining the disease according to the blood flow sound according to the first aspect of the patent application, in the step A, the test subject is a heart or a cardiovascular, and the subject is measured to have blood in the heart or An audio signal flowing inside the cardiovascular tube, in which it is judged whether the subject has a heart or cardiovascular disease in step C. 如申請專利範圍第1項所述之根據血流聲音判斷疾病之方法,在步驟A中,該受測者之受測部位為洗腎瘻管,係量測該受測者其血液在洗腎瘻管內流動的聲音訊號,藉以在步驟C判斷該受測者之洗腎瘻管是否窄化。In the method of determining the disease according to the blood flow sound according to the first aspect of the patent application, in step A, the subject to be tested is a dialysis catheter, and the blood of the subject is measured in the dialysis catheter. The sound signal flowing inside is used to judge whether the dialysis tube of the subject is narrowed in step C. 如申請專利範圍第1項所述之根據血流聲音判斷疾病之方法,其中該受測者為新生兒,該受測部位為該新生兒心臟與肺臟之間的瘻管,在步驟A係量測該新生兒其血液在心臟與肺臟之間的瘻管流動產生的聲音訊號,藉以在步驟C判斷該新生兒心臟與肺臟之間的瘻管是否關閉。The method for judging a disease according to a blood flow sound according to the first aspect of the patent application, wherein the subject is a newborn, and the measured part is a fistula between the heart and the lung of the newborn, and is measured in step A. The newborn produces a sound signal from the blood flow between the heart and the lungs of the newborn, thereby determining in step C whether the fistula between the neonatal heart and the lung is closed. 一種使用於如申請專利範圍第1項所述之根據血流聲音判斷疾病之方法的裝置,包括有:
一訊號接收單元,用以接收步驟A的聲音訊號;
一訊號處理模組,包括有一訊號轉換單元電性連接該訊號接收單元,以及有一輸出單元電性連接該訊號轉換單元,在步驟B中由該訊號轉換單元將該聲音訊號轉換為前述三維頻譜圖,再由該輸出單元輸出;
一圖形辨識模組,包括有一資料庫及一比對單元,該比對單元電性連接該輸出單元,該資料庫儲存有步驟C之三維頻譜資料,該比對單元則接收該三維頻譜圖並與該三維頻譜資料進行比對。
A device for use in a method for determining a disease according to a blood flow sound as described in claim 1 of the patent application, comprising:
a signal receiving unit for receiving the sound signal of step A;
The signal processing module includes a signal conversion unit electrically connected to the signal receiving unit, and an output unit electrically connected to the signal conversion unit. In step B, the signal conversion unit converts the audio signal into the three-dimensional spectrogram. And output by the output unit;
A graphics recognition module includes a data library and a comparison unit electrically connected to the output unit, the database storing the three-dimensional spectral data of step C, and the comparison unit receives the three-dimensional spectrum Align with the three-dimensional spectrum data.
一種根據血流聲音評估疾病治療效果之方法,包括下列步驟:
A.對罹患有影響血流之疾病的一受測者,擷取該受測者罹患有前述疾病之一受測部位在治療前及治療後,其血液在該受測部位體內流動的一聲音訊號;
B.將前述聲音訊號透過一人耳聽覺模型轉換(auditory-based cochlear transform),成為一治療前三維頻譜圖(pre-cochlear spectrogram)及一治療後三維頻譜圖(post-cochlear spectrogram);
C.擷取前述治療前三維頻譜圖及治療後三維頻譜圖中的次頻段的包絡面(extraction the envelop of sub-band signal of cochlear spectrogram),將其定義為時域相關性頻譜圖(temporal correlogram);
D.比對治療前的時域相關性頻譜圖與治療後的時域相關性頻譜圖,根據治療後的時域相關性頻譜圖之雜訊減少結果來評估治療效果。
A method for assessing the therapeutic effect of a disease based on blood flow sounds, comprising the following steps:
A. For a subject suffering from a disease affecting blood flow, the subject is subjected to a sound of blood flowing in the body to be tested before and after treatment of one of the aforementioned diseases. Signal
B. The aforementioned sound signal is transmitted through an auditory-based cochlear transform into a pre-cochlear spectrogram and a post-cochlear spectrogram;
C. Extracting the aforementioned pre-treatment three-dimensional spectrogram and the extraction of the envelop of sub-band signal of cochlear spectrogram, which is defined as a temporal correlogram );
D. Compare the time domain correlation spectrum map before treatment with the time domain correlation spectrum map after treatment, and evaluate the treatment effect according to the noise reduction result of the time domain correlation spectrum map after treatment.
如申請專利範圍第11項所述之根據血流聲音評估疾病治療效果之方法,其中步驟B之人耳聽覺模型轉換(auditory-based cochlear transform)採用:



其中,CS(a,b)代表人耳聽覺模型轉換之輸出,a代表每一頻帶之中心頻率相對於最低頻帶之中心頻率之比值倒數,b代表不同時間位置,s(t)代表所取樣的單一聲波訊號其時間函數,Ψ* a,b為所選用之小波基底模型函數;
計算步驟C之時域相關性頻譜圖 (temporal correlogram)係採用:




其中,m代表的是前述人耳聽覺模型轉換中的CS(a,b)分別在頻帶k,時間n時的三維頻譜圖的包絡線,w代表的是取樣點長度為l的窗函數(window),τ代表的是移動多少訊號取樣點。
The method for assessing the therapeutic effect of a disease according to blood flow sound according to claim 11 of the patent application, wherein the auditory-based cochlear transform of step B adopts:



Where CS(a,b) represents the output of the human auditory model transformation, a represents the inverse of the ratio of the center frequency of each frequency band to the center frequency of the lowest frequency band, b represents different time positions, and s(t) represents the sampled The time function of a single acoustic signal, Ψ * a, b is the selected wavelet base model function;
The time domain correlation spectrum (steporal correlogram) of step C is calculated as follows:




Where m represents the envelope of the three-dimensional spectrogram of CS(a,b) in the above-mentioned human auditory model conversion at frequency band k and time n, respectively, and w represents a window function with a sampling point length of l (window) ), τ represents how many signal sampling points are moved.
如申請專利範圍第11項所述之根據血流聲音評估疾病治療效果之方法,其中前述時域相關性頻譜圖包含有時間、頻率及關聯度係數(correlation coefficient)三個維度,係擷取治療前的時域相關性頻譜圖及治療後的時域相關性頻譜圖的一主頻波峰其頻率的包絡線進行比對。The method for assessing the therapeutic effect of a disease according to blood flow sound according to claim 11 of the patent application scope, wherein the time domain correlation spectrogram includes three dimensions of time, frequency and correlation coefficient, and is a treatment for the disease. The pre-time-domain correlation spectrogram and the time-domain correlation spectrum of the post-treatment time-frequency spectrum are compared by the envelope of the frequency. 如申請專利範圍第11項所述之根據血流聲音評估疾病治療效果之方法,步驟A中罹患有影響血流之疾病的受測者係為罹患開放性動脈導管閉鎖不全症狀的新生兒。The method for assessing the therapeutic effect of the disease according to the blood flow sound as described in claim 11 of the patent application, wherein the subject having the disease affecting the blood flow in the step A is a neonate suffering from an open arterial stenosis. 如申請專利範圍第11項所述之根據血流聲音評估疾病治療效果之方法,步驟A中罹患有影響血流之疾病的受測者係為罹患心臟疾病或心血管疾病的患者。The method for assessing the therapeutic effect of a disease according to blood flow sounds as described in claim 11 of the patent application, wherein the subject having a disease affecting blood flow in step A is a patient suffering from a heart disease or a cardiovascular disease. 如申請專利範圍第11項所述之根據血流聲音評估疾病治療效果之方法,步驟A中罹患有影響血流之疾病的受測者係為罹患洗腎瘻管窄化症狀的洗腎病患。The method for assessing the therapeutic effect of the disease according to the blood flow sound according to the invention of claim 11, wherein the subject having the disease affecting blood flow in the step A is a dialysis patient suffering from a narrowing symptom of the dialysis. 一種使用於如申請專利範圍第11項所述之根據血流聲音評估疾病治療效果之方法的裝置,包括有:
一訊號接收單元,用以接收步驟A的聲音訊號;
一訊號處理模組,包括有一訊號轉換單元電性連接該訊號接收單元,以及有一輸出單元電性連接該訊號轉換單元,在步驟B中由該訊號轉換單元將該聲音訊號轉換為前述治療前三維頻譜圖及治療後三維頻譜圖,並擷取前述治療前的時域相關性頻譜圖及治療後的時域相關性頻譜圖,再由該輸出單元輸出;
一圖形辨識模組,包括有一資料庫及一比對單元,該比對單元電性連接該輸出單元,該資料庫儲存前述治療前的時域相關性頻譜圖,該比對單元則接收該治療後的時域相關性頻譜圖,並與該治療前的時域相關性頻譜圖進行比對。
A device for use in a method for assessing the therapeutic effect of a disease according to blood flow sounds as described in claim 11 of the patent application, comprising:
a signal receiving unit for receiving the sound signal of step A;
The signal processing module includes a signal conversion unit electrically connected to the signal receiving unit, and an output unit electrically connected to the signal conversion unit. In step B, the signal conversion unit converts the sound signal into the pre-treatment three-dimensional image. a spectrogram and a post-treatment three-dimensional spectrogram, and taking the aforementioned time domain correlation spectrogram before treatment and the time domain correlation spectrogram after treatment, and then outputting by the output unit;
A graphics recognition module includes a data library and a comparison unit electrically connected to the output unit, the database storing the time domain correlation spectrum map before the treatment, and the comparison unit receives the treatment The subsequent time domain correlation spectrogram is compared to the pre-treatment time domain correlation spectrogram.
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* Cited by examiner, † Cited by third party
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US6575927B1 (en) * 1998-09-25 2003-06-10 The Regents Of The University Of Michigan System and method for determining blood flow rate in a vessel
US6167765B1 (en) * 1998-09-25 2001-01-02 The Regents Of The University Of Michigan System and method for determining the flow rate of blood in a vessel using doppler frequency signals
DE19901078C1 (en) * 1999-01-14 2000-02-17 Polaschegg Hans Dietrich Monitoring system for fistula or graft has instruments to detect pulse from patient's heart or external blood circulation pump
TWI243048B (en) * 2004-04-21 2005-11-11 Yuh-Jiuan Lin Monitoring fistula device
EP2303357B1 (en) * 2008-06-26 2015-10-28 Gambro Lundia AB Method and device for processing a time-dependent measurement signal

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