TW201432243A - Optical fiber sensing device - Google Patents

Abstract

An optical fiber sensing device used to improve the process efficiency of conventional microfluid sensing devices is disclosed. The optical fiber sensing device includes a base, a microfluidic chip and an optical fiber. The base includes two surfaces and two through holes penetrating through the two surfaces respectively. The microfluidic chip is mounted on the base which includes a first surface, a microfluidic channel and two openings, with the two openings communicating with the first surface respectively and aligning with the two through holes respectively. The optical fiber penetrates into the microfluidic chip and interlaces with the microfluidic channel to form a plurality of intersections.

Description

Optical fiber detecting device

The present invention relates to an optical fiber detecting device, and more particularly to an optical fiber detecting device having a grating formed by a micro flow channel for performing fluid detection.

In recent years, continuous improvement of cell manipulation technology, especially in the need of rapid detection and convenient operation, how to improve the efficiency of biological detection has been widely studied. In medical and biological cell research, most of the liquid detection devices are used to detect and separate cell particles. The conventional liquid detection device is a large-scale instrument, which is a mature and stable technology. For example, flow cytometry is not a modern biological research. One of the missing tools, in addition to the identification of cells, can also analyze cell division wavelength, DNA content, cell death, cell count, cell separation and so on.

There are many types of conventional liquid detection devices. In addition to being a must-have instrument for medical and biological cells, liquid chromatography or mass spectrometry is an indispensable instrument in all fields, through various physical or physical properties of a liquid to be tested. By identifying the chemical properties, the type and concentration of the liquid to be tested, and the size and quantity of the contained particles (for example, specific molecules or cells) can be detected. However, although the conventional liquid detecting device has the advantages of complete functions and accurate detection, the size of the machine is large, and the cost is expensive, which causes inconvenience in use. In addition, in order to improve the detection accuracy, the conventional liquid detecting device usually lacks the integration of the detection function and the multiplex detection capability. Once a plurality of tests are required for a fluid to be tested, or a large number of samples are required to perform the same test, multiple quantities are required. The measuring machine has considerable difficulty in execution, which is easy to reduce the efficiency of detection.

In summary, the conventional liquid detecting device has "poor convenience" and "checking" Many disadvantages such as poor measurement efficiency. In view of the above, there is a need to provide a further improved liquid detecting device for reducing the volume of a liquid or cell detecting device, integrating the detecting function, and achieving the effect of multiplex detection.

The object of the present invention is to provide an optical fiber detecting device capable of using a grating formed by a micro flow channel to cooperate with an optical fiber to detect a fluid to be tested, and to measure the type, concentration and particle size of the fluid to be tested. And the amount and other information, coupled with the small size of the fiber detection device and the ability to integrate a variety of detection functions, has the effect of improving the convenience of fluid detection.

Still another object of the present invention is to provide an optical fiber detecting device having two or more gratings capable of detecting different fluids to be tested or different fluids to be tested, achieving multiplex detection effect, and improving liquid detection. The efficiency of efficiency.

In order to achieve the foregoing objective, the technical content of the present invention includes: a fiber detecting device comprising: a pedestal comprising two surfaces and two through holes penetrating the two surfaces; a wafer coupled to the pedestal, and The chip includes a first surface, a micro flow channel and two openings, wherein the two openings respectively communicate with the micro flow channel and the first surface and are respectively located in the two through holes; and an optical fiber runs through the micro flow channel, and A plurality of crossover positions are formed by interlacing with the microchannels.

In the optical fiber detecting device of the present invention, the micro flow path includes a plurality of bent portions and a plurality of extending portions, and the plurality of extending portions are respectively connected to the two adjacent bent portions.

In the optical fiber detecting device of the present invention, the bent portion is two continuous corners.

In the optical fiber detecting device of the present invention, the two consecutive corners are each 90 degrees.

In the optical fiber detecting device of the present invention, the wafer further includes a second surface opposite to the first surface, the micro flow channel penetrates the second surface, and the optical fiber detecting device The utility model further comprises a frame joint coupled to the second surface and disposed around the outer periphery of the micro flow channel.

In the optical fiber detecting device of the present invention, any two adjacent extending portions have a pitch, and the pitch includes at least one pitch value.

In the optical fiber detecting device of the present invention, the plurality of extension portions are parallel to each other.

In the optical fiber detecting device of the present invention, the two openings are formed at both ends of the micro flow path.

In the optical fiber detecting device of the present invention, the apertures of the two openings respectively correspond to the apertures of the two through holes of the pedestal.

In the optical fiber detecting device of the present invention, the thickness of the wafer is larger than the diameter of the optical fiber.

An optical fiber detecting device comprises: a first seat body, comprising a base, the base comprises two surfaces and two through holes penetrating the two surfaces; a second seat body comprising a base, the base comprises two a surface and a through hole penetrating the two surfaces; a wafer coupled between the first body and the second body, comprising a first surface, a second surface, two micro flow channels, and two first openings And the second opening, wherein the first surface abuts the first seat body, the second surface abuts the second seat body, and the two first openings respectively communicate with one of the micro flow channels and the first surface, And the two first openings respectively face the two through holes of the base of the first base body, the two second openings respectively communicate with the other micro flow channel and the second surface, and the second openings are respectively located a two-hole of the base of the second body; and an optical fiber extending through the two micro-channels and respectively forming a plurality of crossover positions with the two micro-channels.

In the optical fiber detecting device of the present invention, each of the micro flow channels further includes a plurality of bending portions and a plurality of extending portions, and the plurality of extending portions are respectively connected to the two adjacent bending portions.

In the optical fiber detecting device of the present invention, the bent portion is two continuous corners.

In the optical fiber detecting device of the present invention, the two consecutive corners are each 90 degrees.

In the optical fiber detecting device of the present invention, the micro flow path connecting the two first openings penetrates the second surface, and the second base further includes a frame coupled to the second surface and disposed on the micro The runner is outside the week.

In the optical fiber detecting device of the present invention, the micro flow path connecting the two second openings penetrates the first surface, and the first base further includes a frame coupled to the first surface and disposed on the micro The runner is outside the week.

In the optical fiber detecting device of the present invention, in each of the micro flow channels, any two adjacent extending portions have a pitch, and the pitch includes at least one pitch value.

In the optical fiber detecting device of the present invention, the plurality of extending portions are parallel to each other in each of the micro flow paths.

In the optical fiber detecting device of the present invention, the extension portion of the micro flow channel has a distance between the distance from the extension portion of the other micro flow channel and has the same value of the at least one pitch.

In the optical fiber detecting device of the present invention, the extending portion of the micro flow path has a distance between the distance from the extension portion of the other micro flow path, and has a different value of the at least one pitch.

In the optical fiber detecting device of the present invention, the two first openings are formed at two ends of the micro flow passages through which the two first openings are connected, and the two second openings are formed in the micro flow passages through which the second openings are connected. Both ends.

In the optical fiber detecting device of the present invention, the diameters of the two first openings respectively correspond to the apertures of the two through holes of the base of the first base body, and the diameters of the two second openings respectively correspond to the base of the second base body The aperture of the two through holes.

The optical fiber detecting device of the present invention, wherein the thickness of the wafer is larger than the light The diameter of the fiber.

According to the foregoing structure, the optical fiber detecting device of the present invention can be used as a fluid detecting device, and has the advantages of small volume and integration of various detecting functions, and the effect of improving fluid detecting convenience is achieved.

1‧‧‧Base

11‧‧‧Tongkong

12‧‧‧through holes

1’‧‧‧first body

11’‧‧‧Base

111’‧‧‧Tongkong

112’‧‧‧Tongkong

12’‧‧‧ frame

2‧‧‧ wafer

2'‧‧‧ wafer

21‧‧‧ first surface

22‧‧‧ second surface

23‧‧‧Microchannel

231‧‧‧Bend

232‧‧‧Extension

24‧‧‧ openings

25‧‧‧ openings

26‧‧‧Microchannel

261‧‧‧Bend

262‧‧‧ Extension

27‧‧‧ openings

28‧‧‧ openings

3‧‧‧ frame

3’‧‧‧Second body

31’‧‧‧Base

311’‧‧‧Tongkong

312’‧‧‧Tongkong

32’‧‧‧ frame

F‧‧‧Fiber

L‧‧‧Test fluid

w‧‧‧The width of the microchannel

w’‧‧‧The width of the microchannel

h‧‧‧The thickness of the wafer

R‧‧‧Diameter of fiber

Λ‧‧·reflection wavelength

Λ’‧‧·reflection wavelength

D‧‧‧ spacing

D1‧‧‧first spacing value

D2‧‧‧second spacing value

D’‧‧‧ spacing

T‧‧‧data points

A‧‧‧ fold line

B‧‧‧ fold line

Fig. 1 is an exploded perspective view showing a first embodiment of the optical fiber detecting apparatus of the present invention.

Fig. 2 is a plan view showing a first embodiment of the optical fiber detecting device of the present invention.

Figure 3 is a cross-sectional view of the first embodiment of the optical fiber detecting apparatus of the present invention taken along line 2-3-3.

Fig. 4 is a single time detection result of the first embodiment of the optical fiber detecting apparatus of the present invention.

Fig. 5 is a result of long-term detection of the actual test of the first embodiment of the optical fiber detecting apparatus of the present invention.

Figure 6 is a perspective exploded view of a second embodiment of the optical fiber detecting device of the present invention.

Figure 7 is a plan view showing an embodiment of the second embodiment of the optical fiber detecting device of the present invention.

Figure 8 is a plan view showing another embodiment of the second embodiment of the optical fiber detecting device of the present invention.

The above and other objects, features and advantages of the present invention will become more <RTIgt; An exploded perspective view of a first embodiment of the present invention includes a susceptor 1, a wafer 2, and a frame 3. The wafer 2 is disposed between the susceptor 1 and the frame 3 . The material of the susceptor 1, the wafer 2 and the frame 3 is required to be selected by the optical fiber detecting device of the present invention. For example, if the fluid L to be detected is an acidic liquid, The susceptor 1, the wafer 2 and the frame 3 are required to be made of an acid resistant material. In preparation, in other words, the susceptor 1, the wafer 2 and the frame 3 are preferably made of a material resistant to acid and alkali, high and low temperature, corrosion resistant and not easily oxidized, for example, plastic material, glass or metal.

The susceptor 1 includes two surfaces and two through holes 11, 12 extending through the two surfaces. The wafer 2 is a biomedical test wafer comprising a first surface 21, a second surface 22 and a micro flow channel 23. The microchannel 23 is preferably a through-groove structure extending through the first surface 21 and the second surface 22 and forming a continuous curved channel. However, the microchannel 23 may also be a trench structure. The first surface 21 or the second surface 22 is only opened, and the invention is not limited thereto. The microchannel 23 includes a plurality of bent portions 231 and a plurality of extending portions 232. Referring to Figures 2 and 3, respectively, a plan view of a first embodiment of the optical fiber detecting device of the present invention and a cross-sectional view taken along line 2-3-3 of the present invention. Preferably, the bent portion 231 has two consecutive corners, so that the micro flow passage 23 can be steered and extended, and the angles of the two curved corners are preferably 90 degrees, so that the micro flow passage 23 can be formed with a plurality of A continuous bend-like channel with a 180 degree turn. The extending portion 232 is connected to the two adjacent bending portions 231. In the embodiment, the plurality of extending portions 232 are parallel to each other, but the invention is not limited thereto. The two openings 24 and 25 need to communicate with the first surface 21 , and thus may be through holes of the first surface 21 and the second surface 22 , or may be blind holes formed in the first surface 21 , the two openings 24 . And the other two microchannels 23 are connected to each other, and are preferably formed at two ends of the microchannel 23, and the diameters of the two openings 24 and 25 are preferably respectively corresponding to the two through holes 11, 12 of the base 1. Aperture. The wafer 2 is fixed on the susceptor 1 , and the first surface 21 of the wafer 2 abuts the pedestal 1 to form a surface of the through hole 1 , and the two openings 24 and 25 are respectively located Two through holes 11, 12. Thereby, the microchannels 23 are respectively connected to the through holes 11, 12 of the susceptor 1. The chip 2 is further provided with an optical fiber F extending through a plurality of extending portions 232 of the micro flow channel 23, and a plurality of crossing positions are formed at a portion where the optical fiber F and the plurality of extending portions 232 are interdigitated to be fixed to Among the wafers 2.

Referring to Figures 2 and 3, the width w of the microchannel 23 needs to be matched with the design of the fluid L to be tested, which is to be detected by the fiber detecting device of the present invention, so that the fluid L to be tested can be The microchannel 23 flows, so the viscosity coefficient of the fluid L to be tested will limit the minimum value of the width w of the microchannel 23, in other words, the width w needs to at least ensure that the fluid L to be tested can be in the microchannel. Flowing in 23. Furthermore, since the optical fiber F is fixed in the wafer 2, the thickness h of the wafer 2 must be larger than the diameter R of the optical fiber, so that the wafer 2 can completely cover the optical fiber F. In addition, the adjacent spacing portion 232 has a spacing d. In the embodiment, the spacing d includes a first spacing value d1 and a second spacing value d2. The first spacing value d1 is not equal to the The second pitch value d2, and the first pitch value d1 and the second pitch value d2 are alternately formed, that is, if an extension portion 232 and an adjacent extension portion 232 have a first pitch value d1, the The extension 232 and the adjacent extension 232 have a second pitch value d2. With the above structure, since the optical fiber F penetrates through the microchannel 23, a plurality of intersection positions are formed in a staggered manner with the plurality of extension portions 232, and a spacing d between the plurality of extension portions 232 causes the micro flow passage 23 to Equivalently forming a grating structure having a reflection wavelength λ, and forming a fiber grating structure together with the optical fiber F for use in detecting the optical fiber detecting device of the present invention.

More specifically, when a light signal having a continuous wavelength is incident from the optical fiber F toward the microchannel 23, light corresponding to the reflection wavelength λ of the microchannel 23 will be reflected, and the remaining wavelengths are not equal to the reflection wavelength λ. The light will pass through the microchannel 23. The spacing d between the plurality of extensions 232 and the width w of the microchannels 23 both affect the value of the reflection wavelength λ. Further, in the embodiment, the spacing d includes a first spacing value d1 and a first The two spacing values d2, so the relative magnitude of the first spacing value d1 and the second spacing value d2 also affect the value of the reflected wavelength λ. In other words, if the above-mentioned factor affecting the value of the reflection wavelength λ is known, and the liquid to be tested L is not filled in the microchannel 23, the reflection wavelength λ of the microchannel 23 can be estimated.

The frame 3 is a hollow frame disposed on the second surface 22 of the wafer 2, and is preferably disposed on the outer periphery of the microchannel 23 to prevent the liquid L to be tested from flowing through the microchannel 23 In the middle, the microchannel 23 may overflow. However, the frame 3 can be selectively set, and if there is no doubt that the liquid L to be tested may overflow, the frame 3 need not be provided.

Referring to FIGS. 1 to 3, in the actual use of the first embodiment of the optical fiber detecting device of the present invention, the second surface 22 of the wafer 2 is placed horizontally upward, and the through hole 11 of the pedestal 1 is placed. And 12 respectively connected to the injection port and the discharge port of a conventional infusion device, and a liquid to be tested L is injected from the through hole 11 by the conventional infusion device (for example, a pump), and the liquid to be tested L is sequentially passed through the through hole. 11 and the opening 24 of the wafer 2 enters the microchannel 23 and flows along the microchannel 23, and finally is sequentially discharged from the opening 25 and the through hole 12. The conventional infusion device can be controlled to input the liquid L to be tested into the microchannel 23 in a short time or continuously, depending on whether the measurement to be performed is a single time measurement or a long time observation. After the microchannel 23 is filled with the liquid L to be tested, a light source having a continuous wavelength is generated by using a light source, and is incident from the optical fiber F toward the microchannel 23, and is observed by a conventional spectrum analyzer. The light signal of the microchannel 23 (or the light signal reflected by the microchannel 23) can detect the type, concentration, size of the contained liquid (for example, a specific molecule or cell) of the liquid to be tested, and Information such as quantity.

In detail, after the first embodiment of the optical fiber detecting device of the present invention is completed, before the liquid to be tested L is filled in the microchannel 23, the microchannel 23 is equivalently formed with a grating structure and has a fixed structure. The reflection wavelength λ (regardless of the process tolerance of the wafer 2). However, after the microchannel 23 is filled with the liquid L to be tested, the reflection wavelength λ will be affected to change, and the main factors affecting the reflection wavelength λ are as follows:

1. Since the liquid L to be tested will coat the optical fiber F, the difference in properties such as reflectance, refractive index or viscous coefficient may be associated with the microfluid as the type or concentration of the liquid L to be tested is different. The reflection wavelength λ of the track 23 causes unequal effects.

2. With the difference in the type and density of the particles contained in the liquid L to be tested, the difference in size, electrical quantity and quantity will cause the particles to adhere to the surface of the fiber F to be different, thereby affecting the microflow. The reflection wavelength λ of the track 23.

3. If the liquid L to be tested flows through the microchannel 23, a chemical reaction (for example, a redox reaction or a bonding reaction) occurs with time, and the nature of the liquid L to be tested is progressed as the reaction proceeds. When it is changed, the reflection wavelength λ of the microchannel 23 will also be affected. Accordingly, by analyzing the optical signal passing through the microchannel 23, it is possible to identify the change caused by the reflection wavelength λ of the microchannel 23 being affected by the fluid L to be tested, thereby determining the type of the liquid L to be tested, Concentration, size and quantity of particles contained.

Referring to FIG. 4, it is an actual test example of the first embodiment of the optical fiber detecting device of the present invention. If it is known that the reflected wavelength λ of one of the microchannels 23 is 660 μm, a liquid L to be tested is injected into the micro. After the flow channel 23, the wavelength of the optical signal passing through one of the microchannels 23 is measured. It can be seen that the optical signal has a component wavelength of 1566 μm at a data point t, and the intensity is seriously attenuated to about -20.7 dB. It is known that the liquid L to be tested causes the reflection wavelength λ of the microchannel 23 to drift to about 1566 μm. By storing the above result in a conventional database, if an unknown liquid is introduced into the microchannel 23 and the reflection wavelength of the microchannel 23 is 1566 μm, the comparison database is used. The data can determine that the unknown liquid is the liquid L to be tested.

Further, it is known that the liquid to be tested L undergoes a bonding reaction to change the molecular species and density contained in the liquid L to be tested, but the reaction time of the bonding reaction is unknown. The liquid L to be tested is continuously injected into the microchannel 23 to perform long-term detection of the liquid L to be tested. Please refer to FIG. 5 , wherein the fold line A is the intensity of the component having a wavelength of 1566 μm in the optical signal passing through the microchannel 23, and it can be seen that the time is between 0 and 24 hours. The composition with a medium wavelength of 1566 μm is sharply increased, that is, the reflection wavelength λ of the microchannel 23 is rapidly deviating from 1566 μm, so it can be judged that 0 to 24 hours is the most intense time for the bonding reaction; the broken line B is analyzed. The component of the optical signal passing through the microchannel 23, the component of which the intensity is severely attenuated, that is, the reflection wavelength λ of the microchannel 23, can be seen that the reflection wavelength λ of the microchannel 23 reacts with the bond. Carrying out, from the beginning of the 1566μm all the way down. According to this, by detecting the liquid L to be tested that has completed the bonding reaction in advance, recording the reflection wavelength λ of the microchannel 23 in a database, and comparing the value of the line B, the measurement can be performed. The reaction time of the bonding reaction. For example, if the liquid L to be tested that completes the bonding reaction is known, When the reflection wavelength λ of the microchannel 23 drifts to 1547 μm, the reaction time of the bonding reaction is about 48 hours.

Referring to Fig. 6, an exploded perspective view of a second embodiment of the optical fiber detecting apparatus of the present invention includes a first body 1', a wafer 2' and a second body 3'. The wafer 2' is disposed between the first base 1' and the second base 3'.

The first body 1' includes a base 11' and a frame 12'. The pedestal 11' includes two surfaces and two through holes 111', 112' extending through the two surfaces. The frame 12' is a hollow frame, which is disposed in a position offset from the base 11' and can be coupled to the base 11' or separately from the base 11'. The invention is not limited thereto.

The wafer 2' is similar to the wafer 2 of the first embodiment, except that the wafer 2' further includes a microchannel 26 and two openings 27, 28. The microchannel 26 is disposed offset from the microchannel 23. The microchannel 26 has the same structure as the microchannel 23, and also includes a plurality of bent portions 261 and a plurality of extending portions 262. The two openings 27 and 28 need to communicate with the second surface 22, and thus may be through holes of the first surface 21 and the second surface 22, or may be blind holes formed in the second surface 22, the two openings 27 The micro flow channel 26 is further connected to the second flow path 26 and is preferably formed at two ends of the micro flow channel 26. The first surface 21 of the wafer 2' is bonded to the first body 1', and the microchannel 23 is located on the base 11', and the first surface 21 of the wafer 2' abuts the base 11' is formed with one surface of the two through holes 111', 112', and the two openings 24, 25 are respectively located at the two through holes 111', 112', and the diameters of the two openings 24, 25 are preferably respectively corresponding to each other. The aperture of the two through holes 111', 112'. In addition, the micro flow channel 26 is located in the frame 12 ′, and the frame 12 ′ is preferably disposed outside the micro flow channel 26 to prevent a liquid L to be tested from flowing through the micro flow channel 26 . In the middle, the micro-flow path 26 may overflow. However, the frame 12' is selectively configurable, and if there is no doubt that the liquid L to be tested may overflow, the frame 12' need not be provided. The chip 2' is further provided with an optical fiber F extending through the wafer 2', a plurality of extensions 232 of the microchannel 23, and a plurality of extensions 262 of the microchannel 26 for fixing to the microflow. Among the track 23 and the micro flow path 26.

The second base 3' includes a base 31' and a frame 32'. The base 31' includes two surfaces and two through holes 311', 312' penetrating the surface. The frame 32' is a hollow frame, which is disposed in a position offset from the base 31' and can be coupled to the base 31' or separately from the base 31'. The invention is not limited thereto. The second body 3' is bonded to the second surface 22 of the wafer 2', and the microchannel 26 is located on the base 31', and the second surface 22 of the wafer 2' abuts the base 31' is formed with one surface of the two through holes 311', 312', and the two openings 27, 28 are respectively located at the two through holes 311', 312', and the diameters of the two openings 27, 28 are preferably respectively corresponding to each other. The aperture of the two through holes 311', 312'. In addition, the microchannel 23 is located on the frame 32', and the frame 32' is preferably disposed outside the microchannel 23 to prevent a liquid L to be tested from flowing through the microchannel 23. In the middle, the microchannel 23 may overflow. However, the frame 12' is selectively configurable, and if there is no doubt that the liquid L to be tested may overflow, the frame 12' need not be provided.

Referring to FIG. 1 , in the actual use of the second embodiment of the optical fiber detecting device of the present invention, if the micro flow channel 23 is to be used for detecting, the second surface 22 of the wafer 2 ′ is placed horizontally upward, and The two through holes 111' and 112' of the base 11' of the first seat body 1' are respectively connected to the injection port and the discharge port of a conventional infusion device, and a liquid to be tested is used by the conventional infusion device (for example, a pump). L is injected from the through hole 111', and the liquid L to be tested will sequentially enter the micro flow channel 23 from the through hole 111' and the opening 24 of the wafer 2', and flow along the micro flow path 23, and finally The opening 25 and the through hole 112' are sequentially discharged. The conventional infusion device can be controlled to input the liquid L to be tested into the microchannel 23 in a short time or continuously, depending on whether the measurement to be performed is a single time measurement or a long time observation. After the microchannel 23 is filled with the liquid L to be tested, a light source having a continuous wavelength is generated by using a light source, and is incident from the optical fiber F toward the microchannel 23, and is observed by a conventional spectrum analyzer. The light signal of the microchannel 23 (or the light signal reflected by the microchannel 23) can detect the type, concentration, size of the contained liquid (for example, a specific molecule or cell) of the liquid to be tested, and Information such as quantity.

Conversely, if the microchannel 26 is to be used for detection, the wafer 2' The first surface 21 is placed horizontally upward, and the two through holes 311', 312' of the base 31' of the second seat 3' are respectively connected to the injection port and the discharge port of a conventional infusion device, and the conventional infusion device is used. (for example, a pump) injecting a liquid L to be tested from the through hole 311, and the liquid to be tested L will sequentially enter the micro flow path 26 from the through hole 311 and the opening 27 of the wafer 2', and along The microchannel 26 is circulated, and finally discharged through the opening 28 and the through hole 312 in sequence. Depending on whether the desired measurement is a single time measurement or a long time observation, the conventional infusion device can be controlled to input the liquid L to be tested into the micro flow path 26 in a short time or continuously. After the microchannel 26 is filled with the liquid L to be tested, a light source is used to generate a light signal having a continuous wavelength, and the optical fiber F is injected into the microchannel 26 and observed by a conventional spectrum analyzer. The light signal of the microchannel 26 (or the light signal reflected by the microchannel 23) can detect the type, concentration, size of the contained liquid (for example, a specific molecule or cell) of the liquid to be tested, and Information such as quantity.

In the microchannel 23, any two adjacent extensions 232 have a spacing d. Among the microchannels 26, any two adjacent extensions 232 also have a spacing d'. Referring to FIG. 7, a top view of a second embodiment of the optical fiber detecting device of the present invention is used. The distance d between the extending portions 232 is a single value, and the distance d between the extending portions 232 is also It is a single value, and the spacing d is equal to the value of the spacing d'. In other words, the grating structure formed by the microchannel 23 and the microchannel 26 has the same reflection wavelength λ. Thereby, the microchannel 23 and the fiber grating structure formed by the microchannel 26 and the optical fiber F can provide two sets of detection gratings having the same reflection wavelength λ. Therefore, the optical fiber detecting device of the embodiment can simultaneously detect the same conditions of the two groups of liquids L to be tested.

Referring to Fig. 8, there is shown a plan view of another embodiment of the second embodiment of the optical fiber detecting apparatus of the present invention. The distance d between the extending portions 232 is a single value, and the distance d' between the extending portions 232 is also a single value, but the distance d is different from the value of the spacing d'. In other words, the grating structure formed by the microchannel 23 and the microchannel 26 has different reflection wavelengths λ, λ'. Thereby, the microchannel 23 and the microchannel 26 are connected to the optical fiber F The jointly formed fiber grating structure can provide two sets of detection gratings having different reflection wavelengths λ, λ'. Therefore, the optical fiber detecting device of the embodiment can simultaneously perform two sets of detection of different conditions on a liquid L to be tested.

Similarly, in the present embodiment, the micro flow channel 23 and the micro flow channel 26 can detect different liquids L to be tested, respectively, so that the width w of the micro flow channel 23 and the micro flow channel 26 The width w' can be designed to be unequal; in addition, the distance d between the extensions 232 of the microchannel 23 can include a plurality of pitch values, and the distance d' between the extensions 262 of the microchannel 26 can also include a plurality of The spacing value is not limited to the invention.

In summary, the optical fiber detecting device of the present invention can utilize a grating formed by a microchannel 23 to cooperate with an optical fiber F to detect a fluid L to be tested, and the optical fiber detecting device is compared with the conventional liquid detecting device. The instrument is small in size, and can instantly measure the type, concentration and size and quantity of the fluid to be tested, and integrate various detection functions. Therefore, the optical fiber detecting device of the present invention does have the effect of improving the convenience of fluid detection.

Furthermore, the optical fiber detecting device of the present invention has two or more microfluidic channels, and forms two or more optical fiber grating structures together with the optical fiber F, and can respectively detect different fluids L to be tested, or different fluids to be measured L. Detection. In use, since the two groups of micro flow channels are misaligned with each other, and the fiber detecting device can be placed in different directions during the detection, the liquid L to be tested in the two or more micro flow channels can be prevented from being polluted by each other. , effectively achieve the effect of multiplex inspection. Therefore, the optical fiber detecting device of the present invention does have an effect of improving the efficiency of liquid detection.

While the invention has been described in connection with the preferred embodiments described above, it is not intended to limit the scope of the invention. The technical scope of the invention is protected, and therefore the scope of the invention is defined by the scope of the appended claims.

1‧‧‧Base

11‧‧‧Tongkong

12‧‧‧through holes

2‧‧‧ wafer

21‧‧‧ first surface

22‧‧‧ second surface

23‧‧‧Microchannel

231‧‧‧Bend

232‧‧‧Extension

24‧‧‧ openings

25‧‧‧ openings

3‧‧‧ frame

F‧‧‧Fiber

h‧‧‧The thickness of the wafer

Claims (23)

An optical fiber detecting device comprises: a pedestal comprising two surfaces and two through holes penetrating the two surfaces; a wafer coupled to the pedestal, and the wafer comprises a first surface, a micro flow channel and two openings The two openings respectively communicate with the micro flow channel and the first surface and are respectively located in the two through holes; and an optical fiber penetrates the micro flow channel and are interlaced with the micro flow channel to form a plurality of intersection positions. The optical fiber detecting device according to claim 1, wherein the micro flow channel includes a plurality of bent portions and a plurality of extending portions, and the plurality of extending portions are respectively connected to the two adjacent bent portions. The optical fiber detecting device of claim 2, wherein the bent portion is two consecutive corners. The optical fiber detecting device of claim 3, wherein the two consecutive corners are each 90 degrees. The optical fiber detecting device of claim 1, 2, 3 or 4, wherein the wafer further comprises a second surface opposite to the first surface, the micro flow channel penetrates the second surface, and the optical fiber is detected The device further includes a frame coupled to the second surface and disposed around the periphery of the microchannel. The optical fiber detecting device of claim 1, 2, 3 or 4, wherein any two adjacent ones of the extending portions have a pitch, the pitch comprising at least one pitch value. The optical fiber detecting device according to claim 6, wherein the plurality of extending portions are parallel to each other. The optical fiber detecting device according to claim 7, wherein the two openings are formed at both ends of the micro flow path. The optical fiber detecting device according to claim 8, wherein the apertures of the two openings respectively correspond to the apertures of the two through holes of the base. The optical fiber detecting device according to claim 9, wherein the thickness of the wafer is larger than a diameter of the optical fiber. An optical fiber detecting device comprises: a first seat body, comprising a base, the base comprises two surfaces and two through holes penetrating the two surfaces; a second seat body comprising a base, the base comprises two a surface and a through hole penetrating the two surfaces; a wafer coupled between the first body and the second body, comprising a first surface, a second surface, two micro flow channels, and two first openings And the second opening, wherein the first surface abuts the first seat body, the second surface abuts the second seat body, and the two first openings respectively communicate with one of the micro flow channels and the first surface, And the two first openings respectively face the two through holes of the base of the first base body, the two second openings respectively communicate with the other micro flow channel and the second surface, and the second openings are respectively located a two-hole of the base of the second body; and an optical fiber extending through the two micro-channels and respectively forming a plurality of crossover positions with the two micro-channels. The optical fiber detecting device of claim 11, wherein each of the micro flow channels further comprises a plurality of bending portions and a plurality of extending portions, wherein the plurality of extending portions are respectively connected to the two adjacent bending portions . The optical fiber detecting device according to claim 12, wherein the bent portion is two continuous corners. The optical fiber detecting device of claim 13, wherein the two consecutive corners are each 90 degrees. The optical fiber detecting device of claim 11, wherein the micro flow path connecting the two first openings extends through the second surface, and the second base further comprises a frame. The second surface is bonded to the outer surface of the micro flow channel. The optical fiber detecting device of claim 15, wherein the micro flow path connecting the two second openings extends through the first surface, and the first base further comprises a frame coupled to the first surface And ringing outside the microchannel. The optical fiber detecting device of claim 11, wherein the plurality of adjacent extending portions have a pitch between the adjacent ones of the microfluids, and the pitch includes at least one pitch value. The optical fiber detecting device according to claim 17, wherein the plurality of extending portions are parallel to each other in each of the micro flow paths. The optical fiber detecting device of claim 18, wherein the extension portion of the micro flow channel has a distance between the distance from the extension portion of the other micro flow channel, and has the same at least one pitch value. . The optical fiber detecting device of claim 18, wherein the extension portion of the micro flow channel has a distance between the distance from the extension portion of the other micro flow channel, and the at least one spacing is different. Value. The optical fiber detecting device of claim 18, wherein the two first openings are formed at two ends of the micro flow path through which the two first openings are connected, and the two second openings are formed in the second opening Both ends of the connected microchannel. The optical fiber detecting device according to claim 21, wherein the diameters of the two first openings respectively correspond to the apertures of the two through holes of the base of the first base body, and the diameters of the two second openings respectively correspond to the above The aperture of the two through holes of the base of the second body. The optical fiber detecting device of claim 22, wherein the thickness of the wafer is larger than a diameter of the optical fiber.