TW201402169A - Medicament delivery device - Google Patents

Abstract

The present invention relates to a medicament delivery device comprising a generally elongated tubular housing having opposite proximal (10) and distal (12) parts; a needle shield sleeve (20) slidably and coaxially arranged inside the housing and wherein a proximal part of said sleeve protrudes a distance outside the proximal part of the housing; a syringe carrier mechanism comprising a syringe carrier (36) slidably and coaxially arranged within the needle shield sleeve, a syringe (16) comprising a stopper (92), a medicament and a needle, wherein said syringe is coaxially arranged within said syringe carrier, and a holding member (46) connected to the syringe carrier; a first activator member (56) slidably and coaxially arranged within the housing and connected to said needle shield sleeve; a second activator member (66) slidably and coaxially arranged within the first activator member; a drive mechanism slidably and coaxially arranged within the second activator member and releasibly connected to the holding member and to the second activator member, said drive mechanism being controlled by the first and the second activator members; characterized in that said second activator member (66) is arranged with information means arranged to cooperate with corresponding interacting means arranged on the distal part of the elongated tubular housing.

Description

Drug delivery device

The present invention relates to a drug delivery device, and more particularly to a device for providing information on complete drug delivery measures.

There are many drug delivery devices available on the market that can deliver drugs automatically or semi-automatically, including many interactive components to achieve the desired function.

One such delivery device is a syringe capable of delivering a drug, such as the function of puncturing the patient's skin and continuously injecting the drug. A similar device is disclosed in document EP 1349590, which includes an activation mechanism to be presented in the form of a button placed at the end. The button may only be activated when the front end of the device is pressed against the injection site. When the two actions are completed, the puncture mechanism in the syringe is released, whereby the needle is pushed into the patient. The injection is then completed.

When the injection is complete, the patient withdraws the syringe from the injection site, whereby a needle guard is pushed forward until it surrounds the needle and then locked.

For the type of needle described above, the user often wants to know when the injection is complete and the needle can be safely removed. Some inform the user of the injection The solution has been developed.

US 6,221,046 describes an injection device having a "clicking of the end of the injection", including an extension on the elastic label of a dose indicating mechanism. The extended label falls into a groove in the housing, causing an audible click at the end of the injection. US 2004/0097883 discloses a click-and-pop solution similar to the end of the injection.

However, with regard to the drug delivery device that informs the user, even if some solutions have been described, there is still room for improvement, especially regarding the delivery of the drug delivery device.

The primary object of the present invention is to remedy the shortcomings of today's drug delivery devices.

This goal can be accomplished by the characteristics of a separate item of patent scope. A more preferred embodiment of the invention is the subject matter of the scope of this patent.

According to a primary aspect of the present invention, a drug delivery device includes a generally elongated tubular outer casing having opposite proximal and distal portions; a needle guard sleeve slidably and coaxially disposed within the outer casing, and wherein the protective sleeve The proximal end extends beyond the proximal end of the housing; a syringe carrier mechanism includes a syringe carrier slidably and coaxially disposed within the needle guard, the syringe including a plug, a drug and a needle Wherein the syringe is coaxially disposed within the syringe carrier, and a support member is coupled to the syringe carrier; a first activation member is slidably and coaxially disposed within the housing and coupled to the needle protection a second activation member slidably and coaxially disposed within the first activation member; a drive mechanism slidably and coaxially disposed at the second activation a member and releasably coupled to the support member and the second activation member, the drive mechanism being controlled by the first and second activation members; wherein the second activation member is provided with an information device, and the elongated tubular housing end Cooperate with the corresponding interactive device.

According to another aspect of the invention, the information device includes an information member attached to the end transverse wall of the second activation member, and the corresponding interaction means includes an opening disposed on the end wall of the end portion of the elongated tubular casing.

According to another aspect of the invention, the information component is a unique color.

According to another aspect of the present invention, the driving mechanism includes a plunger rod acting on the plug in the barrel, and a first compression spring biased in advance to force the plunger rod to move the syringe carrier mechanism The needle is punctured into the injection site (first step) and the plug is moved to push the drug out through the needle (second step).

According to another aspect of the invention, the plunger rod is slidably and coaxially disposed within the second activation member, and the previously compressed first compression spring is coaxially placed within the plunger rod (proximal end of the plunger rod) Between the wall and the end of the second starting member transverse wall).

According to another aspect of the invention, the second activation member includes an elastic tongue having an annular inward ledge, wherein the support member includes an elastic tongue having an annular inward ledge, and wherein the plunger rod includes a circumferential groove The ledge of the second actuating member and the ledge of the support member have a common shape such that the annular inward wall shelf of the second actuating member and the radially inward ledge of the support member can engage the groove.

According to another aspect of the present invention, the plunger rod is biased against the inwardly biased by the inward ledge of the tongue of the second actuating member in the groove of the plunger rod The force of a compression spring is supported, also by the first activation member and preventing the tongue from moving radially outward.

According to another aspect of the present invention, the apparatus further includes a second compression spring biased in advance to have a second annular end having an annular proximal end that depends on a first activation member, and an annular end that depends on the second activation member Stop the near end of the ledge.

According to another aspect of the present invention, the needle guard is coupled to the first actuating member, and when the proximal end of the needle guard is pressed against the injection, the inward ledge of the tongue of the second actuating member is recessed from the plunger rod When the slot is released, it can be moved coaxially and endally relative to the outer casing and the second actuating member such that the force of the first compression spring that pre-stress is forced to force the plunger rod into the syringe carrying mechanism (first step) and Embolization (second step).

According to another aspect of the present invention, after the end of the plunger rod passes the ledge of the second actuating member, the second actuating member is coaxially and endally moved by the residual force of the first compression spring which is previously biased, so that the tongue is shaped The object moves radially inwardly, whereby the transverse end wall of the second activation member strikes the end wall of the end outer casing portion, and an audible signal is issued indicating that the injection has been completed and the device can be safely removed from the injection.

According to another aspect of the invention, the information member passes through the opening to make it touchable and/or visible when the second activation member is moved coaxially and distally to provide touchable and/or visible information to indicate that the injection has been completed. And the device can be safely removed from the injection.

According to another aspect of the present invention, the needle guard and the first actuating member act on the first drive member by a second compression spring that imparts tension in advance. The force moves coaxially and proximally relative to the outer casing and the second activation member, and thus the needle guard sleeve is coupled to the first activation member to cover the injection needle when the needle guard proximal end exits the injection site.

According to another aspect of the present invention, the first activation member includes a rib on the inner surface thereof, and after the needle guard sleeve is coaxially and proximally moved with the first activation member, interacts with the strip portion of the second activation member to avoid The needle guard is pressed into the device toward the end.

The invention has many advantages. Since the user is provided with information about the completion of the injection, knowing that the injection has been completed, he/she can safely remove the drug delivery device from the injection site.

One advantage is that the residual force of the compression spring device is used to puncture, and the injection is used to provide information to the user.

In this regard, information can be seen, such as: the user can see through the device opening (such as window or channel) that the injection has been implemented. Furthermore, in order to increase visibility, the indication may be bright and/or different from other devices.

Furthermore, the information component can also be made to pass through the device housing, thereby also providing tactile and visual information to the user.

In addition to visual and/or tactile information, the device according to the invention may also have an audible effect, giving a clear sound when the injection has been performed.

A better arrangement is to place the information component at the end of the device, which helps the design because it does not require more components to provide information functionality.

The invention may indicate that the injection is complete in a number of respects.

These and other advantages of the invention will be apparent from the description and appended claims.

10‧‧‧ proximal shell

12‧‧‧End shell

16‧‧‧Syringe

20‧‧‧Needle Cover

36‧‧‧Syringe carrier

46‧‧‧Support members

56‧‧‧First starter component

58‧‧‧Cone

60‧‧‧ ledge

62‧‧‧First ring

64‧‧‧second ring

66‧‧‧Second starting component

68‧‧‧Cuts

70‧‧‧elastic tongue

72‧‧‧Strip

74‧‧‧Inward wall shelf

76‧‧‧End transverse wall

78‧‧‧Information components

80‧‧‧ openings

82‧‧‧End wall

90‧‧‧Plunger rod

92‧‧ ‧ embolization

94‧‧‧First compression spring

96‧‧‧Circular groove

98‧‧‧ Near wall

102‧‧‧Second compression spring

104‧‧‧Stop the ledge

DETAILED DESCRIPTION OF THE INVENTION In the following detailed description, reference is made to the drawings in which: Figure 1 a, b is a cross-sectional view according to the invention, and Figure 1b is rotated 90° of Figure 1a.

Figure 2 is an exploded view according to Figure 1.

Figures 3 to 6 are cross-sectional views of different functional descriptions in accordance with the present invention.

In the current application, the terminus means the drug delivery device or the member that is furthest from the user at the time of injection. Similarly, proximal refers to the end of the drug delivery device or member that is closest to the user at the time of injection.

The drug delivery device (e.g., autoinjector) of the present invention includes a generally elongated tubular outer casing having opposite proximal ends 10 and ends 12 in FIG. The proximal outer casing portion 10 is provided with an elongated opening 14 for viewing the syringe 16 (filled with liquid medication) (Fig. 2). The distal end portion is provided with an engagement means such as an inner surface thereof as an annular recess to interact with a corresponding engagement means (e.g., on the outer side of the proximal end of the proximal end portion).

The device further includes a needle guard 20 (Fig. 2), which is hereinafter referred to as a needle guard, whereby the needle sleeve includes a proximal end portion 22 (having a particular diameter) and a distal end portion 24 (having a larger diameter than the proximal end portion), The two parts are connected by a central conical portion 26 (Fig. 2). Two elongated grooves 28 are provided along the ends of the needle sleeve for viewing the syringe 16 (Fig. 2). On the inner surface of the conical portion 26 is a circumferential ledge 30 (Fig. 2). The two openings 32 at the end of the needle sleeve are on opposite sides, each An opening has an elastic tongue 34 (Fig. 2) that projects slightly inwardly. The needle guard 20 is slidably and coaxially located within the housing, and the proximal end of the boot protrudes a distance from the proximal end of the housing.

The device also includes a syringe carrying mechanism including a syringe carrier 36 slidably and coaxially disposed within the needle guard; the syringe 16 includes a plug 92, a drug and a needle whereby the syringe is coaxially disposed The syringe is carried within the mechanism; and a support member 46 is coupled to the syringe carrier.

The syringe carrier 36 has a generally tubular body with a smaller diameter neck 38 (Fig. 2) at the proximal end of the syringe carrier. At the abutment of the neck there are flow interrupters on either side to form a guide surface 39. These faces cooperate with the corresponding shape of the inner face of the sleeve to create a stop mechanism to prevent rotation of the syringe carrier relative to the needle guard. The end of the syringe carrier has two tongues 40 extending toward the ends, each having an opening 42 and an inwardly facing wall at the end edge of each opening (Fig. 2). The inner surface of the syringe carrier is also provided with a radially inward flange to allow for space between the syringe carrier wall and the syringe 16.

Support member 46 (Fig. 2) includes an annular body 48 having an annular ledge 50 around its circumference and a plurality of resilient tongues 52 facing the end of the device, and wherein each tongue 52 is provided with a radially inward ledge 54 (Figure 1 b).

The device also includes a first activation member 56 slidably and coaxially located within the housing and coupled to the needle guard 20 as described below, which is tubular and includes a ledge 60 having a proximal end conical portion 58 that terminates on the outside ( Figure II). A first annulus 62 is placed on the outside at a distance from the ledge 60 (Fig. 2). A second annulus 64 is disposed further away from the ledge 60.

The device in turn includes a second activation member 66 that is slidably and coaxially located within the first activation member 56 and that is tubular. A plurality of longitudinal cutouts 68 are disposed along the outer ends of the second activation member to form resilient tongues 70 (Fig. 2). The proximal end of the resilient tongue 70 has a slanted transition surface that contacts the large diameter strip 72 (Fig. 3). An annular inward ledge 74 is located on the inner face of the adjoining transition surface (Fig. 1b). Furthermore, the second activation member 66 is provided with an information device that cooperates with the interactive device on the end of the corresponding elongated tubular housing. The information device includes an information member 78 attached to the end transverse wall 76 of the second activation member, and the corresponding interactive device includes an opening 80 on the end wall 82 of the end portion of the elongated tubular casing (Fig. 1a).

The device in turn includes a drive mechanism slidably and coaxially located within the second activation member 66 and releasably coupled to the support member and the second activation member, the drive mechanism being controlled by the first and second activation members, as follows Said.

The driving mechanism includes a plunger 92 acting on the plunger 92 in the barrel 16, and a pre-tensioned first compression spring 94 has a force that forces the plunger to move the syringe carrier mechanism to puncture the needle Enter the injection site (first step) and move the plug to push the drug out through the needle (second step). The plunger rod is slidably and coaxially located within the second activation member, and the first compression spring 94 that imparts tension in advance is coaxially located within the plunger rod (crossing the end wall 98 of the plunger rod and the end of the second activation member) Between the walls 76). Furthermore, a guide rod 100 is located within the first compression spring 94 (Fig. 1a).

The plunger rod 90 is tubular and has an outer diameter that is slightly smaller than the inner diameter of the barrel body. The plunger rod 90 is provided with a circumferential groove 96, and the wall of the second activation member 66 The frame 74 and the ledge 74 of the support member 46 have a common shape such that the annular inward ledge 74 of the second actuating member 66 and the radially inward ledge 54 of the support member 46 can fit into the groove 96 (Fig. 1b) ).

The device further includes a second compression spring 102 that is pre-stressed, a second annulus 64 having an annular proximal end that depends on the first activation member 56, and an annular end that relies on the stop of the second activation member 66. Near end of 104 (Figure 2).

With respect to Figures 3-6, the function of the device according to the invention will be described as follows.

When the device is assembled, the distal outer casing portion 12 is secured to the proximal outer casing portion by suitable engagement means to form an elongated tubular casing, and the first and second activation members are coaxially moved relative to one another. However, when the device is in the non-actuated position, the plunger passes through the inward ledge 74 of the tongue 70 of the second actuating member 66 within the groove 96 of the plunger rod 90, and by surrounding and preventing the tongue 70 The first actuating member 56, which moves radially outward, is supported against the force of the first compression spring 94 which is previously biased. Furthermore, the ledge 54 of the support member 46 is located within the groove 96 (Fig. 1b). An inward ledge on the trailing edge of each opening 42 of the syringe carrier 36 passes through the end face of the annular ledge 50 of the support member 46 to connect the syringe carrier and the support member while the tongue of the needle cover 20 34 engages the end face of the ledge 60 of the first actuating member 56 to connect the needle guard and the first actuating member.

When the proximal end of the needle guard is pressed against the injection, the needle guard and the associated first activation member move coaxially and endally relative to the outer casing and the second activation member against the second compression spring 102 that is previously biased ( Figure 3). When the first actuating member moves toward the end, the strip of the second actuating member The portion 72 is removed from around the first activation member 56 (Fig. 3), and the elasticity of the tongue 70 of the activation device causes the proximal end of the tongue 70 to flex radially outwardly, causing the ledge 74 to be removed from the plunger rod 90. The groove 96 is loosened. However, the ledge 54 of the support member 46 remains within the groove 96 of the plunger rod and the proximal end faces the end of the syringe carrier 36 whereby the force of the first compression spring that imparts tension in advance forces the plunger The rod is moved into the syringe carrying mechanism (first step) whereby the needle is punctured into the injection site.

When the syringe carrier reaches the nearest place, it is forced to stop. However, the force of the first compression spring that imparts tension in advance (acting on the plunger rod) is large enough to force the ledge 54 of the support member 46 out of the groove of the plunger rod.

The force of the first compression spring that imparts tension in advance continues to force the plunger rod into the plug within the barrel (second step), and the liquid drug is injected into the patient until the plug reaches the proximal end of the barrel (Fig. four). After the liquid drug is injected and the end of the plunger rod passes through the ledge 74 of the second activation member 66, the tongue 70 moves radially inward. Since the force of the first compression spring that is previously biased also acts on the inner surface of the end transverse wall 76 of the second actuating member 66, and has a residual force, the second actuating member 66 moves toward the end until the end of the second actuating member 66 is transversely shaped. The outer surface of the wall 76 strikes the inner surface of the end wall 82 of the end outer casing portion 12 to provide an audible signal to the user indicating that the delivery (e.g., injection) has been completed and the device can be safely removed from the injection site (Fig. 5). ).

Again, the protrusion 78 of the second activation member 66 protrudes from the opening 80 to make it touchable and/or visible to provide touchable and/or visible information to indicate that the injection has been completed (Fig. 5), and when the second activation member is coaxial End ground The movement (e.g., the user's finger is placed on the end wall 82, except that the protrusion 78 can be seen through the passage 82), the device can be safely removed from the injection. To enhance visibility, the protrusions can be used in bright colors, unlike the colors of other devices.

The needle guard and the first actuating member act on the first actuating member by a force of a second compression spring 102 that imparts tension in advance, and move coaxially and proximally relative to the outer casing and the second actuating member, thus when the needle guard is near When the end is removed from the injection, the needle guard is attached to the first activation member to cover the injection needle (Fig. 6).

The first activation member 56 includes a rib (not labeled) on its inner surface for interacting with the strap 72 of the second activation member 66 after the needle guard and the first activation member are moved coaxially and proximally to The needle guard sleeve is moved into the device at the end to avoid inadvertent needle sticking.

The embodiments and the drawings described above are only to be considered as limiting examples of the invention, and the invention may be modified in many ways within the scope of the patent.

10‧‧‧ proximal shell

12‧‧‧End shell

16‧‧‧Syringe

22‧‧‧ Near end

36‧‧‧Syringe carrier

76‧‧‧End transverse wall

78‧‧‧Information components

80‧‧‧ openings

82‧‧‧End wall

90‧‧‧Plunger rod

92‧‧ ‧ embolization

94‧‧‧First compression spring

98‧‧‧ Near wall

100‧‧‧guides

Claims (12)

A drug delivery device comprising: a generally elongated tubular housing having opposite proximal ends (10) and a distal end portion (12); a needle guard (20) slidably and coaxially disposed within the outer casing, and wherein The proximal end of the needle guard (20) protrudes a distance outside the proximal end portion (10) of the housing; a syringe carrier mechanism including a syringe carrier (36) slidably and coaxially disposed on the needle guard (20), a syringe (16) includes a plug (92), a drug and a needle, wherein the syringe (16) is coaxially disposed in the syringe carrier (36), and a support The member (46) is coupled to the syringe carrier (36); a first activation member (56) is slidably and coaxially disposed within the housing and coupled to the needle guard (20); a second activation member ( 66) slidably and coaxially disposed within the first activation member (56); a drive mechanism is slidably and coaxially disposed within the second activation member (66) and releasably coupled to the support member (46) And a second actuating member (66), wherein the drive mechanism comprises a plunger rod (90) configured to act on a plug (92) inside the barrel (16) And wherein the plunger rod (90) is slidably and coaxially disposed within the second activation member (66); wherein the second activation member (66) comprises an elastic tongue (70) having a loop shape An inner ledge (74), wherein the support member (46) comprises An elastic tongue (52) having an annular inward ledge (54), and wherein the plunger rod (90) includes a circumferential groove (96) having a ledge with the second activation member (66) (74) in a shape common to the ledge (54) of the support member (46) such that the annular inward ledge (74) of the second actuating member (66) and the radially inward ledge (54) of the support member Assemble into the groove (96). The drug delivery device of claim 1, wherein the second activation member (66) comprises a plurality of longitudinal cutouts (68) disposed along a proximal outer surface of the second activation member (66) Forming the resilient tongue (70), wherein the proximal end of each resilient tongue (70) has a slanted transition surface in contact with a large diameter strip (72), wherein the annular inwardly A ledge (74) is disposed on an interior surface that abuts the transition surface. The drug delivery device of claim 1 or 2, wherein the first activation member (56) comprises a proximal end having a conical portion (58) that terminates in a ledge (60) on an outer surface thereof Where the first annulus (62) is disposed on the outer surface at a distance from the ledge (60), and the second annulus (64) is also disposed further from the ledge (60) At the office. The drug delivery device of claim 2, wherein the band of the second activation member (66) is moved when the first activation member (56) is moved toward the distal end during use of the drug delivery device ( 72) coming out of the periphery of the first actuating member (56), and the resilient nature of the resilient tongue (70) of the second actuating member (66) allows the tongue The proximal end of (70) flexes radially outwardly such that the ledge (74) is released from the groove (96) of the plunger rod (90). The drug delivery device of any one of claims 2 to 4, wherein the first activation member (56) comprises a rib on its inner surface, the needle guard (20) and the first activation member ( 56) after coaxial and proximal movement, the ribs and the strip (72) of the second activation member (66) interact to prevent the needle guard (20) from being pushed toward the end into the device Any attempt. The drug delivery device of any one of claims 1 to 5, wherein the driving mechanism is adapted to accumulate a driving force for moving the syringe carrier mechanism in a first step of piercing the needle into the injection position And moving the plug (92) in a second step of expelling the drug via the needle, and wherein the actuation mechanism is controlled by the first (56) and second (66) activation members. The drug delivery device of any one of claims 1 to 6, wherein the driving mechanism comprises a first compression spring (94) that is pre-stressed, having a force capable of urging the plunger rod (90), The plunger rod moves the syringe carrier mechanism in a first step for piercing the needle into the injection position, and in a second step moves the plug (92) for expelling the drug through the needle. The drug delivery device of claim 7, wherein the pre-tensioned first compression spring (94) is coaxially disposed within the plunger rod (90) and proximal to the plunger rod (90) Between the wall (98) and the end transverse wall (76) of the second activation member (66). For example, the drug delivery device of claim 8 of the patent application An inward ledge (74) of the tongue (70) of the second actuating member (66) located within the groove (96) of the plunger rod (90), and by surrounding and preventing the tongue (70) The first actuating member (56) that moves radially outwardly resists the force of the first compression spring (94) that is pre-stressed to hold the plunger rod (90). The drug delivery device of claim 9, wherein the device further comprises a second compression spring (102) pre-stressed having a second annulus against the first activation member (56) (64) And an annular proximal end portion on the proximal end surface of the stop wall bracket (104) of the second activation member (66). The drug delivery device of claim 10, wherein the needle guard (20) and the first activation member (56) coupled to the needle guard (20) are configured for use as the needle guard ( When the proximal end of 20) is pressed against the injection position, the outer casing and the second activation member (66) are coaxially and axially moved to allow the orientation of the tongue (70) of the second activation member (66). The inner ledge (74) is released from the groove (96) of the plunger rod (90) such that the force from the first compression spring (94) pre-stressed urges the plunger rod (90) to The syringe carrier mechanism is moved in a first step and the plug (92) is moved in a second step. The drug delivery device of any one of claims 1 to 11, wherein the second activation member (66) is configured to have an information member configured to be disposed in the elongated tubular after the drug is completely discharged The corresponding interactive mechanisms on the end portions of the outer casing cooperate such that the remaining driving force of the driving force accumulated in the driving mechanism forces the second starting member (66) Displacement toward the distal end of the elongated tubular casing to produce an audible, visible, and/or tactile feedback to the user regarding the completion of the injection.