TW201338757A - Biosensor with exercise amount measuring function and remote medical system thereof - Google Patents

Abstract

The present invention provides a biosensor with exercise amount measuring function. The biosensor comprises a microprocessor for operating various signals and data; a movement sensing module for detecting a user's movement signal, and is connected with the microprocessor; a biological signal detection module for detecting the user's biological signals, and is connected with the microprocessor; a flash memory for storage the exercise amount and biological signal data operated by the microprocessor; and a display unit, which is connected with the microprocessor, for displaying the operated exercise amount and biological signal data of the user.

Description

Biosensor with exercise measurement function and its remote medical system

The present invention relates to a biosensor, and more particularly to a biosensor having a motion measurement function.

Due to the rapid economic development and changes in the lifestyle of human life, the prevalence of diabetes in the world has risen at an alarming rate, and diabetes has become a major challenge in the medical community. Diabetes is a chronic disease. At present, diabetic patients cannot be cured even if they are treated. Therefore, they can only use control measures to prevent diabetes from worsening and cause complicated complications. Therefore, diabetic patients must closely and carefully monitor the daily blood sugar level in order to obtain good control of diabetes. At present, the mainstream of monitoring blood glucose in diabetic patients daily uses biosensors to detect their blood glucose levels. Taking blood glucose machines as an example, in recent years, blood glucose meters use electrochemical methods to detect blood sugar levels of patients. It can be detected with immobilized glucose oxidase or glucose dehydrogenase, and the daily blood glucose level of diabetic patients can be known.

It is known that regular physical exercise can increase the response of various cells in the body to insulin, making blood sugar more controllable; patients who are injecting insulin may reduce the amount of insulin; and patients with oral hypoglycemic drugs may reduce oral administration. The amount of medicine used even becomes unnecessary. However, in diabetics, skeletal muscle consumes a lot of energy during exercise, which causes blood sugar to drop. In particular, patients who take hypoglycemic drugs or insulin injections may have hypoglycemia. When blood sugar levels are too high, exercise may cause patients. The production of ketone bodies in the body further causes dehydration of the body. Therefore, medical personnel generally recommend that patients with diabetes should pause their exercise when their blood glucose is higher than 250 mg/dl and below 80 mg/dl. Therefore, diabetics must be very careful and pay attention to their physical condition during exercise, and after discussing with their medical staff to evaluate their physical fitness, consider how to perform exercise planning, pay attention to exercise and calories burned daily, and measure changes in blood glucose before and after exercise. In addition, exercise must also be carried out regularly, every day or at least every other day to achieve the effect of reducing and controlling blood sugar, so it is recommended that diabetic patients carry exercise measuring devices during exercise to record the calories burned, and according to This plan and adjust the individual's exercise plan.

However, various motion measuring devices currently available on the market, such as pedometers or wristwatch type motion measuring devices, are only used to measure the amount of exercise that has been performed, and only display the amount of calories burned, but cannot provide blood glucose detection immediately. Function, therefore, if the diabetic patient has a biosensor to detect his or her own blood glucose before and after exercise, it is necessary to immediately measure the blood sugar level after exercise to know the blood sugar level, which causes inconvenience to the diabetic patient. Therefore, how to overcome the above problems has become a major issue.

Accordingly, the inventors provide a biosensor with a motion measurement function, which is a device that combines two functions of motion measurement and biological sensing measurement, and can not only provide users with immediate detection of their own blood glucose values, but also According to the user's living habits, the daily exercise amount of the user is recorded, and then converted into daily calorie consumption, which can provide the user's blood sugar level and daily changes in the calories burned, as an assessment of the influence of the user's daily exercise amount on the blood sugar level. It can be provided to health care providers as an exercise program for assessing individuals and care for diabetes.

Therefore, an object of the present invention is to provide a biosensor with a motion measurement function, comprising: a microprocessor for processing various signals and data; a motion sensing module and the microprocessor Connected to detect a user's motion signal; a biosignal detection module is coupled to the microprocessor for detecting a user's biological signal; a flash memory, the system and the microprocessor And connected to the microprocessor for displaying the amount of motion and biosignal information of the user after the operation .

In a preferred embodiment, the biosensor with the motion measurement function of the present invention can react with a chemical by a biological sample (such as a user's blood, saliva, cerebrospinal fluid, tears, or sweat) to make a biological signal. The detection module measures the biosignal of the user. In a preferred embodiment, the biosignal is a blood glucose level.

In another embodiment, in the biosensor with motion measurement function of the present invention, the biosignal detection module includes an amplifier, a filter, and an analog-to-digital conversion circuit. The amplifier converts the current into a voltage and amplifies the voltage value to match the input range of the circuit. The filter filters out unwanted noise and converts the voltage into a corresponding number via an analog-to-digital conversion circuit. The biosignal information of the user is obtained from the output conversion circuit to the microprocessor operation processing.

In the biosensor with the motion measurement function of the present invention, the motion sensing module can be implemented in various embodiments, wherein the preferred (but not limited to) example motion sensing module comprises: a first direction acceleration sensing a second direction acceleration sensor for sensing a motion signal generated by a second direction when the user moves; a third direction acceleration The sensor is configured to sense a motion signal generated by a third direction when the user moves. In addition, the motion sensing module can further include an amplifier and a filter to amplify the perceptual motion signal and filter the noise.

The terms "first direction acceleration sensor, second direction acceleration sensing and third direction acceleration sensor" are a kind of "three-axis acceleration sensor", and the three-axis acceleration sensor transmits through three-dimensional space. The change, the change of the perceived acceleration force, such as shaking, falling, rising or falling, can be converted into an electrical signal by the triaxial acceleration sensor, or the corresponding action mode can be determined by the waveform generated by the movement change of the acceleration. After receiving the corresponding action mode, the microprocessor calculates the amount of exercise to convert the calorie into the consumed calories, and calculates the amount of exercise for a certain period of time to calculate the calories burned per day. For example, the motion of the user can be classified into sleep, sitting, standing, or walking by the waveform change measured by the acceleration sensor. After the microprocessor receives the corresponding action mode, the corresponding set of sleep, The activity index for sitting, standing, or walking calculates the corresponding number of calories burned per day.

The display unit of the biosensor with the motion measurement function of the present invention may be, for example, a liquid crystal display, which can provide information such as an operation process and a test result to the user.

In the biosensor with the motion measurement function of the present invention, the biosignal detection module may further comprise a temperature detector, since the biosensor itself or the test strip has its applicable ambient temperature range, in order to make the measurement When the unknown variable is minimized, the ambient temperature can be stored together with the biosignal information and the motion signal information after the module completes each measurement. The temperature detector can be composed of a temperature detecting circuit. For example, a current-type temperature sensing element and a series resistor can be used to form a voltage dividing circuit, and the electronic switch can be used to select an output from a current/voltage conversion, an amplifying circuit or itself. Achieved for the signal source.

The biosensor with the motion measurement function of the present invention may further comprise an instant clock, the function of which generates and provides time information used by the user to the biosensor so as to display the current time and the measured value. The combination of biosignal and motion signal information becomes a record store that allows users to track and manage the evolution of their daily biosignal and motion signal information.

In addition, the biosensor with the motion measurement function of the present invention may further be provided with a user operation button, preferably (but not limited to) having four buttons, namely "+", "-", and "Menu". Table) and "enter"; if you do not want to install the user operation button on the biosensor, you can replace it with a touch screen.

In addition, the biosensor with the motion measurement function of the present invention can be equipped with a buzzer or a voice carrier or a chip with a sound source file and a sound source driver, and can provide a description of each operation step of the user.

Another object of the present invention is to provide a method for measuring the amount of exercise using the biosensor having the exercise amount measuring function of the present invention, the steps comprising: initializing a setting to input general information; and a dedicated setting for inputting personal data. Initializing motion information to zero the motion information and recalculating; an acceleration accelerator signal to record the motion signal; a condition determination step to determine whether the time has passed 24:00 on the day, and if not, enter The above-mentioned induction accelerator signal, if it is, records the total amount of exercise yesterday, and enters the above-mentioned initialization motion information, and restarts the exercise amount.

It is still another object of the present invention to provide a remote medical system comprising: a network system, a home care system coupled to the network system, and a medical care system coupled to the network system. The utility model is characterized in that the home care system uses a biosensor with a motion measurement function to detect the motion signal and the physiological signal of the user.

The biosensor with motion measurement function of the present invention further comprises a transmission device, which can connect the personal biometric signal value measured by the individual and the calorie frequency of daily exercise or consumption to the personal computer through the transmission device, and then The data transmission system is transmitted to the medical care system so that the medical staff can evaluate the value by professional judgment or other management software analysis system to plan an effective exercise mode. On the other hand, the transmission device can be replaced with a USB connection device, an infrared transmitter or a Bluetooth technology to transmit the value stored in the biosensor to the personal computer via wireless radio frequency or wireless communication.

The invention is described in more detail in the following detailed description of the preferred embodiments of the invention. Modifications and variations of the embodiments discussed below may be made without departing from the spirit and scope of the invention, and still fall within the scope of the invention.

First, referring to FIG. 1 , which is a configuration block diagram of a biosensor with a motion measurement function according to an embodiment of the present invention, it can be seen that the biosensor with the motion measurement function has a motion sensing module. The first direction acceleration sensor is configured to sense a motion signal generated by the first direction when the user moves, and the second direction acceleration sensor is configured to sense the second direction of the user when moving. The generated motion signal; a third direction acceleration sensor for sensing a motion signal generated by the third direction when the user moves. In addition, the motion sensor having a motion measurement function has a motion sensing module, which further includes an amplifier and a filter to amplify the motion signal and filter the noise; on the other hand, the motion measurement function The biosensor has a biosignal detection module including an amplifier, a filter and an analog-to-digital conversion circuit. The signals measured by the two sets of modules described above can be transmitted to a microprocessor, and then the microprocessor can process the received signals and display them to a display unit.

The biological signal detecting module of the biosensor with the motion measuring function can react with the body fluid of the user to generate a current change, and convert the current into a voltage through the amplifier while amplifying the voltage value to conform to the circuit. The input range is filtered by the filter to remove unnecessary noise, and the voltage is converted into a corresponding number from the output conversion circuit to the microprocessor operation processing by the analog digital conversion circuit to obtain the blood sugar value of the user.

Next, the exercise module for measuring the daily exercise amount is detailed to calculate and evaluate the daily exercise amount of the individual.

In this embodiment, the amount of exercise can measure the amount of vibration or the number of walking steps of the exercise module to obtain the calorie consumption of the individual in daily life. Referring to FIG. 2, a flow chart of steps of measuring a biosensor with a motion measurement function according to an embodiment of the present invention includes an initial setting S110 (of course, when using a motion measurement function, the amount of motion) The biosensor of the measuring function needs to be worn on the user, and the biosensor of the present invention can be designed to be worn on the wrist or worn on the ankle, and the user can input general information. , such as year, date and time and select the test unit to be used, etc.; then, perform a specialization setting S120 to input personal data such as age, sex, height and weight, etc. In addition, the exercise measuring function of the present invention The biosensor is equipped with a voice carrier, and the user's explanation of each operation step is performed, so that the user inputs basic information such as age, gender, height and weight according to the operation explanation; after that, enters a Initializing the motion information S130 to zero the motion information and recalculating; then, entering a recording accelerator signal S140 to accumulate the vibration frequency of the motion or The number of walking steps; afterwards, a condition determining step S170 is entered to determine whether the time has reached 24:00 on the day, and if not, the above-mentioned sensing accelerator signal S140 is entered, and if so, the total amount of motion S180 of yesterday is recorded, and the above is entered. The motion information S130 is initialized, and the amount of exercise is restarted.

Table 1 below is the value of the number of daily vibrations accumulated for one month and the daily blood glucose measured by the biosensor having the exercise amount measuring function of the present invention.

In the above manner, the microprocessor can know the activity amount of the individual's daily life through the motion signal sensed by the acceleration sensor.

In another embodiment, the amount of exercise can be measured by measuring the number of vibrations of the motion module or the number of walking steps, and converting the amount of exercise into calories burned to obtain the calorie expenditure of the individual in daily life. Please refer to FIG. 3, which is a flow chart of the steps of measuring the biosensor with the motion measurement function according to another embodiment of the present invention; the steps are different from the above embodiment in that the measurement step further includes: Determining the action step, and the determining the action step is between recording the inductive accelerator signal S140 and the condition determining step S170, wherein the determining the action step comprises determining the activity classification S150 to confirm the state of the user at the time; and determining the data Whether to accumulate to a certain time step S160, if yes, enter a calculation of the later activity classification movement amount S161 and the update movement amount S163, and if not, proceed to calculate a previous activity classification movement amount S162.

In this embodiment, the activity classification distinguishes the activity classification of the user by the three-dimensional acceleration sensor, and the activity classification can be divided into four categories: sleep, sitting posture, standing posture, and walking. The following is a detailed description of the action mode corresponding to the acceleration sensor; when the acceleration waveform detected by the acceleration sensor does not change after a predetermined time (such as ten minutes), it can be judged as sleep, because the user remains stationary; In the three-dimensional acceleration sensor, only one dimension will have a waveform change, and the acceleration waveform first appears to accelerate downward, and then accelerates upward, then the user can be judged to be standing; otherwise, if the acceleration waveform first appears toward Acceleration, and then there is a downward acceleration, the user is sitting; walking is caused by the hands, feet and body, so the first direction, the second direction and the third direction both generate amplitude, and After a certain period of time, it can be judged that the user is walking.

And in this embodiment, the amount of exercise is converted into calories burned. The following is an example of one of the methods. The total energy consumption per person per day is calculated as follows:

Physical Activity = BMR × Activity Index

Among them, BMR is the minimum amount of calories needed to maintain the vital organs of the human body. Refer to the “Daily Nutrient Recommended Intakes and Descriptions” issued by the Department of Health of the Executive Yuan in 1993, the fifth revision, which is quoted as follows:

PA can be divided into mild, moderate, severe and extremely heavy four levels according to the classification method. Each life activity in each level has an activity index. And one of the body's daily activity = BMR × activity index. The following will exemplify activity indices in which the activity intensity is mild (referring to one-hour walking and light manual or family matters other than opening or shopping, most of which are engaged in sitting work), and are listed in Table 3 below.

Through the above calculation method, the microprocessor can transmit the motion signal sensed by the acceleration sensor and convert it into daily calorie consumption according to the corresponding gender, age and action state in the internally set lookup table.

The user can use the blood glucose test piece before and after the daily eating and before and after the exercise, and measure the blood sugar level by the biosensor with the exercise measuring function, and record the green in the flash memory according to the date classification.

Table 4 below is a value obtained by accumulating one month of daily calories burned per day and daily blood glucose measured by a male sensor of the age of 70 and weighing 70 kg, using the biosensor of the exercise measuring function of the present invention. Taking 2010/10/1 as an example, one of the users consumes 2,265.48 calories per day, which is calculated as follows:

PA = (0.9 × 8 + 1.5 × 8 + 1.6 × 4 + 2.9 × 4) × 0.0145 × 60 × 70 = 2265.48 (large card).

In addition, another object of the present invention is to provide a remote medical system including a network system, a home care system connected to the network system, and a medical care connected to the network system. The system, and the home care system uses a biometric sensor with a motion measurement function to detect the user's motion signals and physiological signals.

The biosensor with the motion measurement function of the present invention further comprises a transmission device for the user to connect the personal measured daily biosignal value and the daily calorie consumption to the personal computer through the transmission device line, and The road system is connected to the hospital's medical care system so that medical staff can evaluate the value or use other professional management software systems to provide a complete picture of the biosignal and calorie consumption, and plan an effective exercise. By using the output value, the software can use the software to map the daily blood glucose and calories burned by daily activities, as shown in Figure 4, or to evaluate the user's daily activities as a medical staff to the user. Suggested basis for living habits, as shown in Figure 5. The output mode or display mode can also be adjusted according to the user's needs. If only the daily blood glucose value is needed, it can be set to output only the daily blood glucose value instead of outputting the daily exercise value as a daily blood glucose management chart, such as Figure 6 shows. Of course, it is also possible to output only the daily exercise value. Of course, the transmission device can be a USB connection device, an infrared transmitter or a Bluetooth technology to transmit the value stored in the biosensor to the computer via wireless radio frequency or wireless communication.

The present invention has been described in detail with reference to the preferred embodiments thereof, but the present invention is not limited to the above-described embodiments, and various changes and modifications may be made to the structures within the scope of the technical idea disclosed herein. Such changes and modifications are still within the scope of the invention.

Fig. 1 is a block diagram showing the internal configuration of a biosensor having a motion measurement function according to an embodiment of the present invention.

Fig. 2 is a flow chart showing the overall operation of the biosensor having the exercise amount measuring function according to the embodiment of the present invention.

Fig. 3 is a flow chart showing the overall operation of the biosensor having the exercise amount measuring function according to another embodiment of the present invention.

FIG. 4 is a comparison diagram of the daily exercise calorie consumption and the daily average blood glucose level after one month of measuring the biosensor with the exercise amount measuring function according to the embodiment of the present invention, wherein the rectangular column is the daily average blood glucose, the triangular cone. The column consumes calories for daily exercise.

Fig. 5 is a schematic view showing the personal living habits measured by the biosensor having the exercise amount measuring function according to the embodiment of the present invention.

Fig. 6 is a management diagram of a blood glucose level for measuring a one-month blood sugar level by a biosensor having an exercise amount measuring function according to an embodiment of the present invention.

Claims (21)

A biosensor with a motion measurement function, comprising: a microprocessor for processing various signals and data; a motion sensing module connected to the microprocessor for detecting a user a motion signal; a biological signal detection module connected to the microprocessor for detecting a biosignal of the user; and a flash memory connected to the microprocessor for storing the micro The amount of motion and biosignal information after the processor is operated; and a display unit connected to the microprocessor for displaying the amount of motion and biosignal information of the user after the operation. A biosensor of claim 1, wherein the biosignal is a blood glucose level. The biosensor of claim 1, wherein the motion sensing module comprises: a first direction acceleration sensor for sensing a motion signal generated by the first direction when the user moves; a second direction acceleration sensor for sensing a motion signal generated by a second direction when the user moves; a third direction acceleration sensor for sensing a motion generated by the third direction when the user moves signal. The biosensor of claim 3, wherein the motion sensing module classifies the motion of the user by the output waveform of the acceleration sensor. A biosensor having a motion measurement function according to claim 4, wherein the action comprises sleeping, sitting, standing, and walking. A biosensor having the motion measurement function of claim 5, wherein the microprocessor converts the motion signal into a calorie consumed per day. The biosensor of claim 1, wherein the motion sensing module further comprises an amplifier, a filter and an analog-to-digital conversion circuit; and the biosignal detection module comprises an amplifier and a filter. And an analog-to-digital conversion circuit. A biosensor having a motion measurement function according to claim 1, further comprising a transmission device. A biosensor having the motion measurement function of claim 8, wherein the transmission device is a USB connection device, an infrared transmitter, or wirelessly or wirelessly via Bluetooth technology. A method for measuring the amount of exercise using the biosensor having the motion measurement function of claim 1, the steps comprising: initializing a setting to input general information; a dedicated setting for inputting personal data; and initializing motion information, Zeroing and recalculating the motion information; sensing the accelerator signal to record the motion signal; and a condition determining step to determine whether the time has passed 24:00 on the day, and if not, entering the above-mentioned induction accelerator signal, If it is, record the total amount of exercise yesterday, and enter the above-mentioned initial motion information, and restart the amount of exercise. The method of claim 10, the method further comprising a determining action step, wherein the determining action step is between the record accelerator signal and the condition determining step, wherein the determining the action step comprises determining a activity classification to confirm the user The state at that time; and a step of judging whether the data has accumulated to a certain time, and if so, entering a calculation of the later activity classification movement amount and the update movement amount, and if not, entering a calculation of the previous activity classification movement amount. According to the method of claim 11, the activity classification is classified by a three-dimensional acceleration sensor, and the activity classification can be classified into four categories: sleep, sitting, standing, and walking. A remote medical system includes a network system, a home care system connected to the network system, and a medical care system connected to the network system, and the home care system utilizes a a biosensor with a motion measurement function for detecting a motion signal and a physiological signal of a user, and the biosensor having a motion measurement function includes: a microprocessor for processing various signals and data; and a motion sensing a module connected to the microprocessor for detecting a motion signal of the user; a biological signal detecting module connected to the microprocessor for detecting a biosignal of the user; a flash memory connected to the microprocessor for storing motion amount and biosignal information after the microprocessor is operated; and a display unit connected to the microprocessor for displaying the operation processing The amount of exercise and biosignal information of the user afterwards. The remote medical system of claim 13, wherein the biosignal is a blood glucose level. The remote medical system of claim 13, wherein the motion sensing module comprises: a first direction acceleration sensor for sensing a motion signal generated by the first direction when the user moves; and a second direction acceleration The sensor is configured to sense a motion signal generated by the second direction when the user moves, and a third direction acceleration sensor is configured to sense a motion signal generated by the third direction when the user moves. The remote medical system of claim 15, wherein the motion sensing module classifies the motion of the user by the output waveform of the acceleration sensor. The remote medical system of claim 16, wherein the action comprises sleeping, sitting, standing, and walking. The remote medical system of claim 17, wherein the microprocessor converts the motion signal to a calorie consumed per day. The remote medical system of claim 13, wherein the motion sensing module further comprises an amplifier, a filter and an analog-to-digital conversion circuit; and the biological signal detection module comprises an amplifier, a filter, and an analogy Digital conversion circuit. A biosensor having a motion measurement function according to claim 13, wherein the biosensor having the motion measurement function is further provided with a transmission device. A biosensor having the motion measurement function of claim 20, wherein the transmission device can be a USB connection device, an infrared transmitter, or wirelessly or wirelessly communicated via Bluetooth technology.