TW201309766A - Hydrophilic film-forming composition, its preparation process, dry hydrophilic film made from the composition, and use thereof - Google Patents

Abstract

The present invention provides a hydrophilic film-forming composition comprising a non-ionic surfactant component selected from alkoxylated alkyl diols, an anchored vinylpyrrolidone/vinylacetate copolymer, a stabilizer component, and a solvent. The present invention also provides a process for preparing the hydrophilic film-forming composition, a dry hydrophilic film made from the composition, and use thereof.

Description

Hydrophilic film forming composition, preparation method thereof, dry hydrophilic film made from the composition and use thereof

The present invention relates to a hydrophilic film forming composition, a process for producing the same, a hydrophilic dry film made from the composition, and use thereof.

Optically transparent and hydrophilic articles are widely used in everyday life. Examples of such optically transparent and hydrophilic articles include protective eye shields (eg goggles, face shields, surgery). Masks and helmets, etc., eyeglass lenses, decorative eyeglass frames, motor vehicle windows, windshields, etc. If there is a way to offset the nature of the fogging of these objects during use, the value of such objects can be increased. In order to achieve this, there is a particular need for a coating that forms a hydrophilic and anti-fogging film. US 6,040,053 A discloses a coating composition which imparts antireflective and antifogging properties to a substrate coated therewith, the coating composition comprising an inorganic metal oxide and a decane or a decane oligomer, the coating composition It is especially used in the manufacture of disposable surgical masks and face masks.

Some devices, such as diagnostic test devices (eg, blood glucose test strips, urine test strips, pregnancy test devices, etc.), are constructed of one or more substrates made of materials having physical or chemical properties that promote fluid transport. However, they are unable to achieve the desired effect. It is known in the art to enhance fluid transport on a substrate by applying a surfactant coating to the substrate to form a hydrophilic surface. US 7,378,451 B2 discloses a hydrophilic surfactant composition having a stable hydrophilic property comprising a surfactant component and a stabilizer component, the hydrophilic surfactant composition being applied to the surface of the substrate by the following means : depositing a surfactant solution on at least a portion of the surface of the substrate, and then drying the surfactant solution to form a dry coating on the surface of the substrate. No. 4,824,640 discloses a transparent carrier reagent layer for an analytical agent for dry detection of a solvent composition of a water-borne sample, wherein one layer comprises a water-soluble or water-swellable component selected from the group consisting of polyacrylamide. , polyacrylic acid, fiber ether, polyethyleneimine, polyvinyl alcohol, copolymer of vinyl alcohol and vinyl acetate, gelatin, gelatin, alginate, and polyvinylpyrrolidone, and substantially water-insoluble a film forming component selected from the group consisting of polystyrenesulfonic acid, cellulose ester, polyvinyl acetate, polyamine, polycarbonate, polyether-carbonate, ionic polyurethane , nonionic polyurethanes, mixtures thereof and copolymers thereof.

However, some surfactants are not suitable for use in storage devices that have been subjected to prolonged periods of time, especially at elevated temperatures, and/or are not suitable for use in articles in which reagents, adhesives, dyes, drugs, excipients or other contaminants are present. In the structure, the hydrophilic properties provided by the surfactant coating disappear with time or due to high temperatures.

Contamination is an inevitable result of human handling or contact with materials during lamination, which may be volatile or mobile and may deposit on or be combined with the surfactant composition being applied. Contact with matter. For example, pressure sensitive or structural adhesives are known to typically contain significant amounts of monomers, catalysts, plasticizers, tackers, and other components that move over time and deposit at the interface. The active agent composition is contacted with or in contact with the surfactant composition to impart hydrophilic character thereto. A protective film can be used to avoid contamination, however, de-lamination can also result in the release of the hydrophilic surfactant coating.

The present invention provides a hydrophilic film forming composition comprising a nonionic surfactant component selected from the group consisting of alkoxylated alkyl glycols, anchored vinylpyrrolidone/vinyl acetate copolymer, Stabilizer ingredients, and solvents. The hydrophilic film forming composition of the present invention can form a coating on a substrate which is heat resistant, has antifogging property and durability, and can maintain its hydrophilic property at room temperature even at high temperatures. Fluid delivery can be promoted and anchoring forces can be provided to the coated substrate.

In one aspect, the present invention provides a hydrophilic film forming composition comprising from about 0.02 wt% to about 5 wt% of a nonionic interfacial activity selected from an alkoxylated alkanediol, based on the total weight of the composition. Agent component; from about 0.01 wt% to about 5 wt% of the stabilizer component; from about 35 wt% to about 0.5 wt% of an anchored vinylpyrrolidone/vinyl acetate copolymer; and the balance of solvent.

The hydrophilic film forming composition of the present invention comprises about 0.02 wt%, or about 0.05 wt% or about 0.1 wt% of a nonionic surfactant component. The hydrophilic film forming compositions of the present invention comprise up to about 5 wt%, or about 4 wt% or about 3 wt% of a nonionic surfactant component. In one embodiment, the hydrophilic film forming composition of the present invention comprises from about 0.02 wt% to about 5 wt% of a nonionic surfactant component. In certain other embodiments, the hydrophilic film forming compositions of the present invention comprise from about 0.05 wt% to about 4 wt% or from about 0.10 wt% to about 3 wt% of a nonionic surfactant component. The nonionic surfactant component is selected from alkoxylated alkanediols such as alkoxylated _C2-24 alkanediols or alkoxylated _C2-12 alkanediols. As used herein, the term "alkoxylation" means that the surfactant has been reacted with an alkylene oxide such that one or more units of the alkylene oxide are covalently bonded to the surfactant. . In a preferred embodiment, the nonionic surfactant component is 2,5,8,11-tetramethyl-6-dodecynyl-5,8-diol ethoxylate (2, 5,8,11-tetramethyl-6-dodecyn-5,8-diol ethoxylate).

Typically, the hydrophilic film forming composition of the present invention comprises about 0.01 wt%, about 0.05 wt% or about 0.1 wt% of a stabilizer component, and the hydrophilic film forming composition of the present invention comprises up to about 5 wt%, about 4 wt. % or about 3 wt% of the stabilizer component. For example, the hydrophilic film forming composition of the present invention comprises from about 0.01 wt% to about 5 wt%, or from about 0.05 wt% to about 4 wt% or from about 0.10 wt% to about 3 wt% of the stabilizer component. The stabilizer component of the hydrophilic film forming composition of the present invention may comprise one or more compounds which extend the time during which the surfactant imparts hydrophilic properties to the substrate to which the hydrophilic film forming composition is applied. The stabilizer component can be selected to substantially not offset the hydrophilic character of the surfactant, and may in fact be selected to contribute to the hydrophilic character of the hydrophilic film forming composition. In most embodiments, the stabilizer component of the hydrophilic film forming composition can have a melting point above about 23 ° C. In certain aspects, the stabilizer component can have a temperature above about 35 ° C or at least about 45. °C melting point. In certain embodiments, the stabilizer component can contribute to the hydrophilic character of the hydrophilic film forming composition. In certain embodiments, the stabilizer component comprises an alkyl, aralkyl or alkaryl sulfonate, sulfate, phosphonate or phosphate surfactant having from about 8 to about 24 carbon atoms. It does not prevent the hydrophilic film forming composition from forming a hydrophilic surface and has a melting point above about 25 °C. In certain embodiments, the stabilizer has an alkyl, aralkyl or alkaryl chain of from about 10 to about 18 carbon atoms, and in certain other embodiments, the stabilizer has from about 10 to about 14 An alkyl, aralkyl or alkaryl chain of a carbon atom, for example 12 carbon atoms. In certain instances, the stabilizer component can have a melting point above about 45 ° C when free of any solvent. The alkyl group can be linear, branched, cyclic, or any combination thereof. In a particular embodiment, sodium dodecylbenzene sulfonate is used as a stabilizer.

The hydrophilic film forming composition of the present invention comprises about 0.5 wt% or about 1 wt% of an anchored vinylpyrrolidone/vinyl acetate copolymer, and the hydrophilic film forming composition of the present invention contains up to 35 wt%, or 25 A wt% or 20 wt% anchored vinylpyrrolidone/vinyl acetate copolymer. In certain embodiments, the hydrophilic film forming compositions of the present invention comprise from about 35 wt% to about 0.5 wt% of an anchored vinylpyrrolidone/vinyl acetate copolymer. In certain other embodiments, the hydrophilic film forming compositions of the present invention comprise from about 25 wt% to about 1 wt% or from about 20 wt% to about 1 wt% of an anchored vinylpyrrolidone/vinyl acetate copolymer. Things. The anchored vinylpyrrolidone/vinyl acetate copolymer has a molecular weight (Mw) of from about 13,000 daltons to about 57,000 daltons or from about 15,000 daltons to about 56,000 daltons. The anchored vinylpyrrolidone/vinyl acetate copolymer comprises repeating units of the formula:

Wherein the weight ratio (n/m) of the vinyl acetate unit to the vinylpyrrolidone unit is from 70/30 to 30/70, preferably from 70/30 to 50/50.

Any solvent useful for the production of the hydrophilic film forming composition can be used in the present invention, and the solvent may be an aqueous or organic solvent such as a hydroalcoholic solvent. Suitable solvents include water and organic solvents such as, but not limited to, ketones, ethers, and alcohols. Suitable alcohols include methanol, ethanol, 1-propanol, 2-propanol, isopropanol, n-butanol, and isobutanol. In certain embodiments, suitable solvents may include hydroalcoholic solvents such as a 70/30 mixture of isopropanol and water.

According to an embodiment of the present invention, the hydrophilic film forming composition comprises from about 0.05% by weight to about 4% by weight, based on the total weight of the composition, of a nonionic surfactant component, about 0.05% by weight to About 4 wt% of the stabilizer component, from about 25 wt% to about 1 wt% of the anchored vinylpyrrolidone/vinyl acetate copolymer, and the balance of solvents. According to another embodiment of the present invention, the hydrophilic film forming composition comprises from about 0.10 wt% to about 3 wt% of a nonionic surfactant component, of about 0.10 wt%, based on the total weight of the composition. To about 3 wt% of the stabilizer component, from about 20 wt% to about 1 wt% of the anchored vinylpyrrolidone/vinyl acetate copolymer, and the balance of solvents.

The hydrophilic film forming composition can be deposited on any surface which requires the characteristics of the hydrophilic film forming composition of the present invention. For example, the hydrophilic film forming composition of the present invention can be applied to the surface of a substrate and then dried to be used in the base. A hydrophilic film is formed on the material to thereby derive a dry hydrophilic film. The hydrophilic film forming composition of the present invention can be applied to the surface of an object and dried to form an object coated with a hydrophilic coating, and the aqueous material can be uniformly dispersed on the hydrophilic coating of the object. The article can be any object having an aqueous dispersion requirement, such as a mirror, eye mask, spectacle lens, decorative glass frame or window.

The hydrophilic film forming composition of the present invention may also be deposited on at least a portion of the surface of the device, the device being designed to regulate the movement of the liquid sample, including but not limited to performing diagnostic or detection testing of the liquid sample. Device. Such devices may also require a hydrophilic surface to facilitate delivery of at least a portion of the liquid sample from one location to another on the device. However, the surface of the device through which the sample normally traverses or passes may not have sufficient hydrophilicity to provide suitable efficacy, in which case the hydrophilic film forming composition of the present invention may be deposited on at least a portion of the fluid transport surface, To facilitate fluid delivery of a liquid sample sufficient to provide adequate performance. The hydrophilic film forming composition can also be deposited in different patterns to control the flow of fluid in a particular manner, such as a continuous, discontinuous or repeating pattern.

The hydrophilic film forming composition in the form of a solution as described above may be deposited on at least a portion of the surface of the hydrophilic film forming composition required, and the hydrophilic film forming composition may be deposited by any suitable method known in the art. Methods include, but are not limited to, spray coating, roller coating, gravure coating, wire-bar coating, dip or sub-coating, extrusion (mold) coating , air knife coating, sliding coating, blade coating, electrostatic coating, inkjet printing, or flow coating.

In another aspect, the present invention relates to a method of preparing the above hydrophilic film forming composition comprising forming an aqueous phase containing a nonionic surfactant component, a stabilizer component, and water to form an anchored vinylpyrrolidone/ The organic phase of the vinyl acetate copolymer and the solvent, and the aqueous phase is mixed with the organic phase.

Typically, the preparation process is carried out at room temperature. Preferably, the preparation process can be carried out by heating at a temperature from about room temperature to below the boiling point of the solvent. For example, when isopropanol is used as the solvent, the preparation can be carried out at room temperature to about 80 °C.

In still another aspect, the present invention relates to a dry hydrophilic membrane comprising: a substrate, a hydrophilic layer formed on the substrate, and, if desired, a protective layer applied to the hydrophilic layer.

The hydrophilic layer of the dry hydrophilic film can be formed by applying the above-described hydrophilic film forming composition of the present invention to the surface of the substrate, and then drying the surface of the substrate, thereby providing a nonionic property. The surfactant component, the stabilizer component, and the hydrophilic layer anchoring the vinylpyrrolidone/vinyl acetate copolymer. A protective layer may be applied to the hydrophilic layer if necessary.

The substrate can be constructed of any material that is at least partially coatable under the physical and structural conditions to which it is intended. Suitable substrates include, but are not limited to, glass, metal, and polymeric substrates of various structures and compositions, including flat disks, screen films, nonwovens, test tubes, capillaries, flat or structural films, and films/films or films/non-woven fabrics. Laminate. In most aspects, such substrates are non-porous. The most preferred substrate is a film that may or may not contain a three-dimensional structure such as grooves, pyramids, bags, and the like. Suitable substrate polymerization compositions and morphologies which can be coated with the hydrophilic film forming compositions of the present invention are described, for example, in US Pat. No. 5,514,120, issued May 7, 1996; US Pat. No. 5,728,446; US Pat. No. 6,290,685, issued Sep. 18, 2001, US Pat. No. 6,375,871, issued Apr. 23, 2002, and US Pat. No. 6,420,622, issued on July 16, 2002; And US Ser. No. 09/612,418, filed on July 7, 2000. The morphological substrates described in these prior art documents are suitable regardless of the materials used to form the substrate. The polymeric substrate can be formed by any suitable means including extrusion, injection molding, blown film, lamination, casting, and the like.

The hydrophilic film forming composition of the present invention can be dried by any suitable means. The phrase "dried" or "dried" as used herein refers to a method of removing a solvent in which a hydrophilic film forming composition is dissolved, which may or may not contain water, for example, the hydrophilic film forming composition may be borrowed. The coated substrate is dried by heating in a recirculating hot air oven, infrared oven or radio frequency oven. Further, the hydrophilic film forming composition can be preliminarily dried by simple evaporation or forced air drying without heating. The heating temperature and time can be determined in part by the physical or chemical composition of the substrate, ie some substrate materials can tolerate higher temperatures without changing the specific physical or chemical properties of the substrate after the coating process is completed. . Other substrates may have embossed structures or other microstructures that require higher or lower thermodynamic morphology to evenly dry the coating.

The dry hydrophilic membrane can have any desired thickness for a particular purpose. For example, the dry hydrophilic membrane can have a thickness of from about 50 nm to about 9,250 nm, preferably from about 100 nm to about 5,000 nm.

The dry hydrophilic film made of the hydrophilic film forming composition of the present invention can form a coating on a substrate which is heat-resistant, anti-fogging and durable, and can maintain its hydrophilic property at room temperature. Fluid delivery can be promoted even at elevated temperatures and anchoring forces can be provided to the coated substrate. The dry hydrophilic membrane can be used in different hydrophilic applications, such as protective eye shields (eg goggles, face shields, surgical masks and helmets), spectacle lenses, decorative eyeglass frames, motor vehicles Windows, and windshields, etc. Further, the dry hydrophilic membrane can be used as a coating for contacting or transporting body fluids in a medical diagnostic test device such as human blood, human blood components, urine, mucus, and the like.

The following examples are intended to illustrate the invention and are not intended to limit the scope of the invention, which are described in detail in the foregoing. In the examples, parts, ratios, and percentages are by weight unless otherwise indicated.

Example

In the following examples, representative hydrophilic film forming compositions of the present invention were prepared using the materials listed in Table 1 and weight percentages:

raw material:

Dynol 604 is a 2,5,8,11-tetramethyl-6-dodecynyl-5,8-diol ethoxylate commercially available from Air Products and Chemicals, Inc.

Siponate DS-10 is sodium dodecylbenzene sulfonate commercially available from Rhodia Inc.

PVP-VA 1335 is a 30% vinylpyrrolidone/70% vinyl acetate copolymer commercially available from International Specialty Products company with a percent solids ranging from 48% to 52%.

PVP-VA 1735 is a 70% vinylpyrrolidone/30% vinyl acetate copolymer having a high glass transition temperature (Tg) commercially available from International Specialty Products Company with a percent solids ranging from 48% to 52%.

PVP-VA S630 is a 97% dry powder with 60% vinylpyrrolidone/40% vinyl acetate copolymer commercially available from International Specialty Products company.

The protective tape 1T01L is a polyester acrylic tape having a low viscosity and a steel adhesion (ATS) of 10-30 gf/in, which is commercially available from 3M.

Protective tape 2T01S is a polyester acrylic tape with low adhesion and 4 gf/in steel adhesion (ATS), commercially available from 3M.

Example 1 :

In a 250 ml vessel, 0.39 g of Siponate DS-10 was dissolved in 83.64 ml of deionized water with stirring to form an aqueous solution. 0.81 g of Dynol 604 was added to the aqueous solution and stirring was continued for 15 minutes until a homogeneous aqueous solution was obtained. In a separate 500 ml vessel, 15 grams of PVP/VA I335 was dissolved in 200.16 grams of isopropanol with stirring to form an organic solution. The aqueous solution is incorporated into the organic solution with stirring to form a hydrophilic film forming composition.

Example 2:

In a 250 ml vessel, 0.39 g of Siponate DS-10 was dissolved in 77.64 ml of deionized water with stirring to form an aqueous solution. 0.81 g of Dynol 604 was added to the aqueous solution and stirring was continued for 15 minutes until a homogeneous aqueous solution was obtained. In a separate 500 ml vessel, 30 grams of PVP/VA I335 was dissolved in 191.16 grams of isopropanol with stirring to form an organic solution. The aqueous solution is incorporated into the organic solution with stirring to form a hydrophilic film forming composition.

Example 3:

In a 250 ml vessel, 0.78 g of Siponate DS-10 was dissolved in 89.64 ml of deionized water with stirring to form an aqueous solution. 3.24 grams of Dynol 604 was added to the aqueous solution and stirring was continued for 15 minutes until a homogeneous aqueous solution was obtained. In a separate 500 ml vessel, 3.0 g of PVP/VA I335 was dissolved in 203.34 g of isopropanol with stirring to form an organic solution. The aqueous solution is incorporated into the organic solution with stirring to form a hydrophilic film forming composition.

Example 4:

In a 250 ml vessel, 13.5 grams of Siponate DS-10 was dissolved in 90 ml of deionized water with stirring to form an aqueous solution. 13.5 grams of Dynol 604 was added to the aqueous solution and stirring was continued for 15 minutes until a homogeneous aqueous solution was obtained. In a separate 500 ml vessel, 180 grams of PVP/VA I335 was dissolved in 3 grams of isopropanol with stirring to form an organic solution. The aqueous solution is incorporated into the organic solution with stirring to form a hydrophilic film forming composition.

Example 5:

In a 250 ml vessel, 6.0 g of Siponate DS-10 was dissolved in 90 ml of deionized water with stirring to form an aqueous solution. 6.0 grams of Dynol 604 was added to the aqueous solution and stirring was continued for 15 minutes until a homogeneous aqueous solution was obtained. In a separate 500 ml vessel, 90 g of PVP/VA I335 was dissolved in 108 g of isopropanol with stirring to form an organic solution. The aqueous solution is incorporated into the organic solution with stirring to form a hydrophilic film forming composition.

Example 6:

In a 250 ml vessel, 0.78 g of Siponate DS-10 was dissolved in 85.44 ml of deionized water with stirring to form an aqueous solution. 1.62 grams of Dynol 604 was added to the aqueous solution and stirring was continued for 15 minutes until a homogeneous aqueous solution was obtained. In a separate 500 ml vessel, 15 grams of PVP/VA I335 was dissolved in 197.16 grams of isopropanol with stirring to form an organic solution. The aqueous solution is incorporated into the organic solution with stirring to form a hydrophilic film forming composition.

Example 7:

In a 250 ml vessel, 0.78 g of Siponate DS-10 was dissolved in 86.64 ml of deionized water with stirring to form an aqueous solution. 1.62 grams of Dynol 604 was added to the aqueous solution and stirring was continued for 15 minutes until a homogeneous aqueous solution was obtained. In a separate 500 ml vessel, 1.5 g of PVP/VA I335 and 6.0 g of PVP/VA I735 were dissolved in 203.46 g of isopropyl alcohol with stirring to form an organic solution. The aqueous solution is incorporated into the organic solution with stirring to form a hydrophilic film forming composition.

Example 8:

In a 250 ml vessel, 0.78 g of Siponate DS-10 was dissolved in 83.76 ml of deionized water with stirring to form an aqueous solution. 1.62 grams of Dynol 604 was added to the aqueous solution and stirring was continued for 15 minutes until a homogeneous aqueous solution was obtained. In a separate 500 ml vessel, 15 grams of PVP/VA S630 was dissolved in 198.84 grams of isopropanol with stirring to form an organic solution. The aqueous solution is incorporated into the organic solution with stirring to form a hydrophilic film forming composition.

Example 9:

In a 250 ml vessel, 0.15 g of Siponate DS-10 was dissolved in 90 ml of deionized water with stirring to form an aqueous solution. 0.15 grams of Dynol 604 was added to the aqueous solution and stirring was continued for 15 minutes until a homogeneous aqueous solution was obtained. In a separate 500 ml vessel, 7.5 grams of PVP/VA I335 was dissolved in 202.2 grams of isopropanol with stirring to form an organic solution. The aqueous solution is incorporated into the organic solution with stirring to form a hydrophilic film forming composition.

Film coating:

The hydrophilic film forming composition described above is applied to the surface of a polyester substrate by a spray method using a wire coater or a gravure roll of a pilot coater to form a coating. In this example, about 5 ml of the above hydrophilic film forming composition was applied to a polyester substrate of 20 cm wide x 70 cm long. When a wire bar coating was used, the above hydrophilic film forming composition was applied using a Webster, N.Y., RDS 9 wire bar to form a wet film having a thickness of 20.57 μ.

Carry out the following tests:

A. Droplet diffusion (wet) test:

This test is to determine the degree of diffusion or wettability of the hydrophilic film forming composition on the test film. A sample of 6 inches wide and 6 inches long was cut from the product roll as a test film. All test films were placed on a flat surface, and 3 μl of a dye solution was applied to each test film to bring the surface of the test film into contact with the dye solution. The droplets were allowed to disperse to their maximum extent and the droplets on the test membrane were then dried in air for 10 minutes. The diameter of the droplets is determined by placing the film on paper having a predetermined circumference of various diameters. Record the diameter of the droplet (mm). The irregular shaped droplets are marked as "NC" (non-circular).

B. anchored force test:

This test is to determine the anchoring properties of the hydrophilic layer when stored at room temperature and at elevated temperatures. The hydrophilic layer on the polyester film was covered with a protective layer, and the protective layer was manually peeled off after 30 minutes at room temperature and after storage for 30 minutes at 100 ° C (HT). The hydrophilic layer was subjected to a droplet diffusion test to determine the retention of hydrophilicity. The protective layer used in this test was a polyester tape "protective tape 1T01L" from 3M with a low-viscosity acrylic adhesive and a polyester tape with a low-viscosity pressure-sensitive polyoxygenated adhesive from 3M." Protective tape 2T01S".

The hydrophilic film forming composition of the present invention and the hydrophilic dry film obtained therefrom and the droplet diffusion (wetting) test and anchoring force test of the comparative examples are shown in Table 2.

Typically, the membrane having no hydrophilic coating has a droplet diameter of about 2.5 (mm). According to the above-described droplet diffusion test results, the hydrophilicity of the film coated with the hydrophilic film forming composition of the present invention is dramatically increased, and the results of the droplet diffusion test and the anchoring force test are compared, even after the protective layer is peeled off. Hydrophilicity can still be maintained. Further, the hydrophilicity of the film coated with the hydrophilic film forming composition of the present invention is stabilized even after storage at a high temperature. Since the hydrophilic film forming composition of the present invention has tolerable hydrophilicity to liquid dispersibility, those skilled in the art will appreciate that it can also achieve antifogging properties.

Claims (15)

A hydrophilic film forming composition comprising, from about 0.02% by weight to about 5% by weight, based on the total weight of the composition, of a nonionic surfactant component selected from the group consisting of alkoxylated alkanediols; about 0.01 wt% % to about 5 wt% of the stabilizer component; about 35 wt% to about 0.5 wt% of an anchored vinylpyrrolidone/vinyl acetate copolymer; and the balance of solvents. The hydrophilic film forming composition of claim 1, wherein the nonionic surfactant component is selected from the group consisting of alkoxylated C _2-24 alkanediols. The hydrophilic film forming composition of claim 1, wherein the nonionic surfactant component is selected from the group consisting of alkoxylated C _2-12 alkanediols. The hydrophilic film forming composition of claim 3, wherein the nonionic surfactant component is 2,5,8,11-tetramethyl-6-dodecynyl-5,8-diol ethoxylate (2,5,8,11-tetramethyl-6-dodecyn-5,8-diolethoxylate). The hydrophilic film forming composition of claim 1, wherein the stabilizer component is selected from the group consisting of C _8-24 alkyl sulfonate, C _8-24 aralkyl sulfonate, and C _8-24 alkyl aryl sulfonic acid An anionic stabilizer for the group consisting of salts. The hydrophilic film forming composition of claim 5, wherein the stabilizer component is sodium dodecylbenzenesulfonate. The hydrophilic film forming composition of claim 1, wherein the anchored vinylpyrrolidone/vinyl acetate copolymer has a molecular weight (Mw) of from about 13,000 daltons to about 57,000 daltons. The hydrophilic film forming composition of claim 1, wherein the anchored vinylpyrrolidone/vinyl acetate copolymer has a molecular weight (Mw) of from about 15,000 daltons to about 56,000 daltons. The hydrophilic film forming composition of claim 1, which comprises from about 0.05% by weight to about 4% by weight, based on the total weight of the composition, of a nonionic surfactant component, from about 0.05% by weight to about 4% by weight. The stabilizer component, from about 25 wt% to about 1 wt% of the anchored vinylpyrrolidone/vinyl acetate copolymer, and the balance of solvent. The hydrophilic film forming composition of claim 9, which comprises from about 0.10 wt% to about 3 wt% of a nonionic surfactant component, from about 0.10 wt% to about 3 wt%, based on the total weight of the composition. The stabilizer component, from about 20% to about 1% by weight of the anchored vinylpyrrolidone/vinyl acetate copolymer, and the balance of solvent. A dry hydrophilic film comprising: a substrate, a hydrophilic layer formed on the substrate, and, if desired, a protective layer applied to the hydrophilic layer, wherein the hydrophilic layer is coated by the coating items 1 to 10 The hydrophilic film forming composition of any one of them is applied to a substrate, and the coated substrate is dried. A method for producing a hydrophilic film forming composition according to any one of claims 1 to 10, which comprises forming an aqueous phase containing a nonionic surfactant component, a stabilizer component, and water to form an anchored vinylpyrrole The organic phase of the ketone/vinyl acetate copolymer and the solvent, and the aqueous phase is mixed with the organic phase. A body fluid test sample characterized by comprising a dry hydrophilic membrane as defined in claim 11. An article characterized in that at least one surface thereof is coated with the hydrophilic film forming composition according to any one of claims 1 to 10. The article of claim 14, which is selected from the group consisting of a mirror, an eye mask, an eyeglass lens, a decorative glass frame or a window.