201243427 六、發明說明： 【發明所屬之技術領威】 [_] I發明是有關於，種隱形眼鏡及其製造方法’特別是有 關於一種具有孔隙的高透氧隱形眼鏡及其製造方法。 【先前技術】 [0002]長久以來，眼睛視力的受損和退化困擾著人們許久，尤 其是在工業革命、資訊革命之後’人們的生活由農業社 會到工商業社會，隨著資訊爆炸現象的產生’現代人必 ^ 需花更多時間和精力去接收更多資訊。在這情況下’眼 睛所扮演的重要性更勝以往。但也因為工作份量的加重 ，造成現代人視力受損的比率增加’視力退化的程度也 在持續升高。無論是視力橋正手術、平時眼睛的保養方 式或是用以矯正視力所最常配戴的傳統框架式眼鏡與隱 形眼鏡，各種有助於視力改善的技術因此有其迫切需求 [0003] 目前，人們配戴隱形眼鏡來矯正視力的情形非常普遍。 〇 由於隱形眼鏡沒有厚重的邊框或鏡片，因此使用上不會 感到負擔也不會影響到外在的美觀。此外，對於需要高 度數眼鏡的使用者來說，相較於配戴傳統框架式眼鏡， 隱形眼鏡所造成的影像放大或縮小比例的影響較為輕微 ，而能帶給使用者較佳的視野。 [0004] 然而，根據調查指出，超過九成隱形眼鏡族都有角膜缺 氧徵兆。角膜缺氧初期可能沒有明顯症狀，所以角膜健 康問題容易被忽視。角膜提供眼睛總屈光率約75%，為維 持透明度，角膜細胞沒有血管輸送氧氣，必須直接藉與 1012001821-0 10110100#單編號A〇1〇l 第3頁/共21頁 201243427 ^氣接觸獲得氧氣來進行新陳代謝。若角膜因配戴低透 乳隱形眼鏡無法取得足純氣，就會自雜的增生血管 ’利用血液輸送氧氣給缺氧的角膜，因而使得眼白處易 生成較多的微血管。 [0005] 此外，當角膜長時間處在缺氧的狀態下，很可能造成角 膜新生血管增生、角臈内皮細胞受損、變形或角膜水腫 等嚴重問題產生，且角臈缺氧會使上皮增加細菌黏附， 容易產生角膜發炎狀況。若持續純角膜缺氧問題而延 誤處理，嚴重時料能造餘力的永久損傷而導致失明 _]為解決隱形眼鏡透氧率低的問題，大部分發明皆著墨在 隱形眼鏡成分的改變，以期可望提高隱形眼鏡之透氧率 。例如，美國專利第4,711，943號揭示一種含有水分之 軟質隱形眼鏡，其由-種兼具醯胺結構與石m结構的 物質化合物所形成’但所述化合物物質卻會造成鏡片濕 潤度的降低，並使鏡>；容易沾染類脂物等物質。此外， 亦有利用放電（eiectrical discharge)或雷射照射 (laser irradiati〇n)等多種不同的製程來增加隱形眼 鏡上的孔隙來提尚其透氧率之方法。然而，上述製程會 造成樹脂的透明度喪失降低之缺點，進而使得對隱形眼 鏡材料的選擇上有較多限制。 【發明内容】 [0007]有鑑於上述習知技藝之問題，本發明之目的在於提供一 種具有孔隙的高透氧隱形眼鏡及其製造方法，以解決使 用者長時間配戴隱形眼鏡下而造成角膜缺氧之問題。 10110100产單編號第4頁/共21頁 1012001821 201243427 [0008] 根據本發明之目的，提出一種具有孔隙之高透氧隱形眼 鏡之製造方法，其步驟包含：均勻混合一水溶性鹽與一 具親水性單體之隱形眼鏡配方，以形成一混合配方；將 混合配方鑄模並成型為一隱形眼鏡；以及藉由一水溶液 水化已成型之隱形眼鏡，以將水溶性鹽溶解析出，使水 化後之隱形眼鏡的表面與内部生成具有複數個孔隙。 [0009] 較佳地，該些孔隙之直徑可介於0. 01 //m至50 之間 [0010] 較佳地，水溶性鹽可包括含納、奸、妈、鎂、鐵、鋅、 銅或锰之鹽類。 [0011] 較佳地，水溶性鹽佔混合配方之重量百分比濃度可為 0. 0 1 w t % 至 3 0 w t %。 [0012] 較佳地，水溶性鹽佔混合配方之重量百分比濃度可為0. 1 wt%至10 wt% 。 [0013] 較佳地，親水性單體可包含苯甲酮化合物。201243427 VI. Description of the Invention: [Technical Leadership of the Invention] [I] The invention relates to a contact lens and a method of manufacturing the same, and particularly relates to a high oxygen permeability contact lens having pores and a method of manufacturing the same. [Prior Art] [0002] For a long time, the damage and degradation of eyesight have plagued people for a long time, especially after the industrial revolution and the information revolution. 'People's life from agricultural society to industrial and commercial society, with the emergence of information explosion phenomenon' Modern people must spend more time and energy to receive more information. In this case, the importance of the eye is more important than ever. However, because of the increase in the weight of work, the rate of visual impairment in modern people has increased. The degree of visual deterioration has also continued to rise. Whether it is vision bridge surgery, usual eye care, or traditional frame glasses and contact lenses that are most commonly used to correct vision, there are urgent needs for technologies that contribute to vision improvement [0003] It is very common for people to wear contact lenses to correct their vision. 〇 Since contact lenses do not have a thick frame or lens, they do not feel burdensome or affect the external appearance. In addition, for users who need high-profile glasses, the effect of the enlargement or reduction of the image caused by the contact lens is relatively slight compared to wearing conventional frame glasses, and can give the user a better view. [0004] However, according to the survey, more than 90% of the contact lens families have signs of corneal hypoxia. There may be no obvious symptoms in the early stage of corneal hypoxia, so corneal health problems are easily overlooked. The cornea provides a total refractive index of the eye of about 75%. In order to maintain transparency, the cornea cells have no vascular delivery of oxygen, and must be directly obtained by 1012001821-0 10110100#单号A〇1〇l Page 3 of 21 201243427 Oxygen is used for metabolism. If the cornea is unable to obtain pure gas by wearing low-transparent contact lenses, it will use the blood to deliver oxygen to the hypoxic cornea, thus making it easier to produce more microvessels in the white of the eye. [0005] In addition, when the cornea is in a state of hypoxia for a long time, it is likely to cause serious problems such as corneal neovascularization, keratinocyte endothelial cell damage, deformation or corneal edema, and the lack of oxygen in the horn will increase the epithelium. Bacterial adhesion, prone to corneal inflammation. If the treatment of delayed corneal hypoxia is delayed, the permanent damage of the residual force can lead to blindness. In order to solve the problem of low oxygen permeability of contact lenses, most of the inventions are in the process of changing the composition of contact lenses. Hope to improve the oxygen permeability of contact lenses. For example, U.S. Patent No. 4,711,943 discloses a soft contact lens containing water which is formed from a compound having both a guanamine structure and a stone m structure, but the compound material causes a decrease in the wettability of the lens. And make the mirror >; easy to contaminate substances such as lipids. In addition, there are also a variety of different processes, such as discharge or laser irradiation, to increase the porosity of the contact lens to improve its oxygen permeability. However, the above process causes a disadvantage of a decrease in the transparency of the resin, which in turn leads to more restrictions on the selection of the material for the contact lens. SUMMARY OF THE INVENTION [0007] In view of the above problems of the prior art, the object of the present invention is to provide a high oxygen permeability contact lens with pores and a manufacturing method thereof, to solve the problem that the user wears a contact lens for a long time to cause the cornea The problem of lack of oxygen. 10110100 Production No. Page 4 / 21 pages 1012001821 201243427 [0008] According to the object of the present invention, a method for manufacturing a high oxygen permeability contact lens having pores is provided, the steps comprising: uniformly mixing a water-soluble salt with a hydrophilic a contact lens formulation of a single monomer to form a mixed formulation; molding and molding the mixed formulation into a contact lens; and hydrating the formed contact lens by an aqueous solution to dissolve and precipitate the water-soluble salt to be hydrated The surface and interior of the contact lens have a plurality of apertures. [0010] Preferably, the diameter of the pores may be between 0.01 and 0.5 to 50 [0010] Preferably, the water-soluble salt may include sodium, mai, mother, magnesium, iron, zinc, a salt of copper or manganese. [0011] Preferably, the water-soluble salt may comprise from 0. 0 1 w t % to 3 0 w t % by weight of the mixed formulation. 1重量%至10重量百分比。 [0012] Preferably, the water-soluble salt by weight of the mixed formula may be 0. 1 wt% to 10 wt%. [0013] Preferably, the hydrophilic monomer may comprise a benzophenone compound.
[0014] 較佳地，隱形眼鏡配方可包含甲基丙烯酸羥乙酯（ 2-hydroxyethyl methacrylate) 、2—甲基-2-丙烯 酸-2, 3-二經基丙酯（glycerol monomethacrylate) 、丙三醇（propan-l，2,3-triol)、乙二醇二甲基丙 烯酸醋（ethylene glycol dimethacrylate)、2-羥基-2-曱基-1-苯基-1-丙酮（ 2-hydroxy-2-methy1-pheny1-propane-1-one )、苯 基雙（2,4, 6-三甲基苯曱醯基）氧化膦（ phenylbis(2, 4, 6-trimethyIbenzoy1)phosphine 1012001821-0 10110100#單編號A〇101 第5頁/共21頁 201243427 [0015] [0016] [0017] oxide)、以及2-丙烯酸基-2-甲基-ij，_[(9 1〇_二 氫-9’ 10-二氧-1，4-蒽基）雙（亞胺-4,卜笨_2,卜乙基） 酯](2-propenoic acid, 2-methyl-l，1，-[(9, l〇-dihydro-9, l〇-di〇xo-i，4-phenylene-2, l-ethanediyl)]ester)。 此外’本發明更提出-種種具有絲之高透氧隱形眼鏡 ’其係由上述製造方法所製得。 承上所述，依本發明之具有孔隙的高透氧隱形眼鏡及其 製造方法，其可具有一或多個下述優點： (1)在本發明之高透氧隱形眼鏡之製造方法中，隱形眼 鏡上的孔隙係藉由生理可正常代謝之水溶性鹽與具親水 性單體之隱形眼鏡配方相混合後，再析出水溶性鹽而形 成。故相對於傳統方法，本發明之製造方法簡單且容易 ，因此不需額外使用複雜性較高之雷射製程以得到相同 效果之孔隙生成，故本發明之簡易方式即可達到增加透 氧功效之目的。 anthracei [0018] [0019] (2) 因本發明之高透氧隱形眼鏡之製造方法係可採用成 本較低之水溶性鹽與親水性單體的水化作用來產生孔隙 ，故在製程上較使用雷射照射等傳統方式為節省成本。 (3) 本發明之高透氡隱形眼鏡之製造方法 业非藉由 改變隱形眼鏡之組成成分以增加隱形眼鏡之透氧率， 可保持隱形眼鏡之濕潤度且可避免沾染類脂物等污染物 〇 【實施方式】 10110100#單編號 A0101 第6頁/共21頁 1012001821-0 201243427 [0020]實施例1 ··本發明之高透氧隱形眼鏡之製造方法 _]冑參閱第1圖，其係為本發明之高透氧隱形眼鏡之製造方 法之一實施例之流程圖。圖中，本發明之高透氧隱形眼 鏡之製造方法的步驟包含：步驟S11，均勻混合水溶性鹽 與具親水性單體之隱形眼鏡配方，以形成—混合配方； 步驟S12，將混合配方鑄模並成型為隱形眼鏡；以及步驟 S13，藉由一水溶液水化已成型之隱形眼鏡，以將水溶性 鹽溶解析出，使水化後之隱形眼鏡的表面與内部生成複 0 數個孔隙。 [0022] 其中，該些孔隙之直徑係介於〇.〇1 #„!至5〇 之間， 且水溶性鹽佔混合配方之重量百分比濃度可為〇〇1 wt% 至30 wt% ’而較佳為〇· 1 wt%至1〇 wt%。 [0023] 較佳地’上述水溶性鹽可包括含鈉、鉀、鈣、錢、鐵、 鋅、銅或錳之金屬元素所組成之鹽類，且其鹽類皆為生 理可正常代謝之鹽類，故不會對使用者造成生理上的毒 Q 性與負擔。而隱形眼鏡配方包括親水單體、甲基丙嫦酸 經乙醋（2-hydroxyethyl methacrylate)、2-曱基 -2-丙稀酸-2, 3-二經基丙醋（glycerol monomethacrylate )、丙三醇（ propan-l，2,3-triol)、乙二醇二曱基丙烯酸酯（ ethylene glycol dimethacrylate)、2-經基-2-甲 基_1-苯基-I-丙酮（ 2-hydroxy-2-methy1-pheny1-propane-1-one )、笨 基雙（2,4,6-三甲基苯甲醯基）氧化膦（ phenylbis(2,4,6-trimethylbenzoy1)phosphine lOllOlGG#單編號删1 第 7 頁 / 共 21 頁 1012001821-0 201243427 oxide)、以及2-丙烯酸基-2-曱基-1,1，-[(9，1〇-二 氫-9, 10-二氧-1，4 -蒽基）雙（亞胺-4，1-苯—2, 1-乙基） 酯](2-propenoic acid, 2 methyl-1, 1 -[(9, 10~dihydro-9,10-dioxo-l,4-anthracei bis(imino-4,1- phenylene-2， l-ethanediyl)]ester)。 [0024] 上述親水性單體係包括具有不同官能基之苯曱酮化合物 ’其化學結構如下所示：[0014] Preferably, the contact lens formulation may comprise 2-hydroxyethyl methacrylate, 2-methyl-2-acrylic acid-2, 3-glycolyl monomethacrylate, C3 Alcohol (propan-l, 2,3-triol), ethylene glycol dimethacrylate, 2-hydroxy-2-mercapto-1-phenyl-1-propanone (2-hydroxy-2) -methy1-pheny1-propane-1-one ), phenylbis(2,4,6-trimethylphenylindenyl)phosphine oxide (phenylbis(2,4,6-trimethyIbenzoy1)phosphine 1012001821-0 10110100#单单No. A 〇 101 Page 5 / 21 pages 201243427 [0015] [0017] oxide and 2-acryloyl-2-methyl-ij, _[(9 1〇_dihydro-9' 10 -2-oxo-1,4-indenyl) bis(imine-4, bung-2-, ethyl)] 2-propenoic acid, 2-methyl-l,1,-[(9, l〇-dihydro -9, l〇-di〇xo-i, 4-phenylene-2, l-ethanediyl)]ester). Further, the present invention further proposes a variety of high oxygen permeability contact lenses having a silk which are produced by the above-described manufacturing method. According to the present invention, a high oxygen permeability contact lens having pores and a method for producing the same according to the present invention may have one or more of the following advantages: (1) in the method for producing a high oxygen permeability contact lens of the present invention, The pores on the contact lens are formed by mixing a water-soluble salt which is physiologically and normally metabolizable with a contact lens formulation having a hydrophilic monomer, and then depositing a water-soluble salt. Therefore, the manufacturing method of the present invention is simple and easy compared with the conventional method, so that it is not necessary to additionally use a complicated laser process to obtain pore formation of the same effect, so that the simple method of the present invention can achieve an increase in oxygen permeability. purpose. Anthracei [0019] (2) The method for producing a high oxygen permeability contact lens of the present invention can use the hydration of a lower cost water-soluble salt and a hydrophilic monomer to generate pores, so in the process Traditional methods such as laser irradiation are used to save costs. (3) The method for manufacturing a high-permeability contact lens of the present invention can maintain the moisture permeability of the contact lens by changing the composition of the contact lens, thereby maintaining the wettability of the contact lens and avoiding contamination such as lipids. 〇【Embodiment】 10110100#单号A0101 Page 6/21 pages 1012001821-0 201243427 [0020] Example 1 · The manufacturing method of the high oxygen permeability contact lens of the present invention _] 第 Refer to Fig. 1 A flow chart of one embodiment of a method for producing a high oxygen permeability contact lens of the present invention. In the figure, the method for manufacturing the high oxygen permeability contact lens of the present invention comprises: step S11, uniformly mixing a water-soluble salt with a contact lens formulation having a hydrophilic monomer to form a mixed formula; and step S12, molding the mixed formula And forming into a contact lens; and in step S13, the formed contact lens is hydrated by an aqueous solution to dissolve and precipitate the water-soluble salt, so that a plurality of pores are formed on the surface and the inside of the hydrated contact lens. [0022] wherein the diameter of the pores is between 〇.〇1 #„! to 5〇, and the water-soluble salt accounts for 〇〇1 wt% to 30 wt% of the mixed formula. Preferably, it is from 1 wt% to 1 wt%. [0023] Preferably, the above water-soluble salt may include a salt composed of a metal element containing sodium, potassium, calcium, money, iron, zinc, copper or manganese. Class, and its salts are physiologically and normally metabolized salts, so it will not cause physiological toxicity and burden to users. The contact lens formula includes hydrophilic monomer and methyl propyl citrate via vinegar ( 2-hydroxyethyl methacrylate), 2-mercapto-2-propionic acid-2, 3-glycolyl methacrylate (glycerol monomethacrylate), glycerol (propan-l, 2,3-triol), ethylene glycol Ethylene glycol dimethacrylate, 2-hydroxy-2-methy1-pheny-propane-1-one, stupid double 2,4,6-trimethylbenzimidyl) phosphine oxide (phenylbis(2,4,6-trimethylbenzoy1)phosphine lOllOlGG# single number deletion 1 page 7 / 21 page 1012001821-0 201243427 oxide), and 2 -propylene Acid-2-mercapto-1,1,-[(9,1〇-dihydro-9, 10-dioxo-1,4-indenyl) bis(imine-4,1-benzene-2, 1-propenoic acid, 2 methyl-1, 1 -[(9, 10~dihydro-9, 10-dioxo-l, 4-anthracei bis(imino-4,1-phenylene-2) , l-ethanediyl)]ester) [0024] The above hydrophilic single system includes a benzophenone compound having a different functional group, and its chemical structure is as follows:
II
[0025] ^可為丙稀酸乙酯（-C_C-C00_C = c)或甲基丙烯醯氧基 (-0-CO-COC)。當\為丙烯酸乙酯時，親水性單體為 2-（4-苯甲醯基-3_經基苯氧基）丙烯酸乙酯（ 2-(4-benzoyl-3-hydroxyphenoxy)ethyl acrylate )。而當\為甲基丙烯醯氧基時，親水性單體則為4_甲 基丙稀醒氣基-2 -經基二苯曱_ ( 4-methacryl〇xy-2-hydroxybenzophenone)。 2-(4-笨曱醯基一3_羥基苯氧基）丙烯酸乙酯與4一曱基丙 烯醯氧基-2-羥基二笨甲酮之化學結構分別如下列化合物 1及化合物2所示。[0025] It may be ethyl acrylate (-C_C-C00_C = c) or methacryloxy group (-0-CO-COC). When \ is ethyl acrylate, the hydrophilic monomer is 2-(4-benzoyl-3-hydroxyphenoxy)ethyl acrylate. When \ is a methacryloxycarbonyl group, the hydrophilic monomer is 4-methacryl 〇xy-2-hydroxybenzophenone. The chemical structures of ethyl 2-(4-cuminyl-3-hydroxyphenoxy)acrylate and 4-mercaptopropenyloxy-2-hydroxydibenzophenone are shown in the following compounds 1 and 2, respectively. .
Ο OHΟ OH
第8頁/共21頁 iOllGioo#單編號 A0101 1012001821-0 201243427 [0026] Ο [0027]Page 8 of 21 iOllGioo#Single Number A0101 1012001821-0 201243427 [0026] Ο [0027]
而在隱形眼鏡配方中，化合物1之重量百分比範圍為 0.001 wt%至10 wt%，化合物2之重量混合比例可為 0.001 wt%至10 wt%。曱基丙烯酸羥乙酯之重量百分比 範圍係可為〇.〇1 wt%至99 wt%，2-曱基-2-丙烯酸 -2, 3-二羥基丙酯之重量百分比範圍係可為〇. 〇1 wt%至 99 wt%，丙三醇之重量百分比範圍係可為〇.〇1 wt%至 50 wt%’乙二醇二甲基丙烯酸酯之重量百分比範圍係可 為0.01 wt%至30 wt%’2_起基_2_甲基_1-苯基-1 -丙 酮之重量百分比範圍係可為0.01 wt%至10 wt%，笨基雙 (2, 4, 6-三甲基苯甲醯基）氧化膦之重量百分比範圍係可 為0.01 wt%至10 wt%，2-丙烯酸基-2-甲基-1，Γ -[(9, 10-二氫-9, 10-二氧-1，4-蒽基）雙（亞胺-4, 1-苯 -2, 1-乙基）酯]之重量百分比範圍係可為〇. 〇0〇ι wt%至 1 wt%。 較佳地，化合物1之重量百分比範圍可為〇.〇1 wt%至2 wt% ’化合物2之重量百分比可為〇. 01 wt%至2 wt%。甲 基丙烯酸羥乙酯之重量百分比可為20 wt%〜55 wt%，2_ 甲基-2-丙烯酸-2, 3-二羥基丙酯之重量百分比範圍可為 37 wt%至48 wt%，丙三醇之重量百分比範圍可為1 wt% 至35 wt%’乙二醇二曱基丙烯酸酯之重量百分比範圍可 為0.01 wt%至10 wt%’ 2-羥基-2-曱基-1-苯基-1一丙 酮之重量百分比範圍可為〇. 1 wt%至1. 5 wt%，笨基雙 (2, 4, 6-三甲基苯甲醯基）氧化膦之重量百分比範圍可為 0.01 wt% 至 1 wt%’2-丙烯酸基-2-甲基-1，1， -[(9, 10-二氫-9, 10-二氧-1，4-蒽基）雙（亞胺-4, 苯 10110100^單編號 A0101 第9頁/共21頁 1012001821-0 201243427 -2, 1-乙基）酯]之重量百分比範圍可為〇. 〇〇1 wt%si Wt% 〇 [0028] [0029] [0030] [0031] 更L地’化合物1之重量百分比範圍可為〇. 262 wt%至 0.69 wt%，化合物2之重量百分比可為0.587 wt%至 〇· 972 wt%。甲基丙烯酸羥乙酯之重量百分比範圍可為 29.1 wt% 至 46.35 wt%; 2-曱基-2-丙烯酸-2, 3-二羥 基丙醋之重量百分比範圍可為40.74 wt%至44.29 wt% ;丙三醇之重量百分比範圍可為8.73以％至26 265 wt%;乙二醇二曱基丙烯酸酯之重量百分比範圍可為 0.485 wt%至 1.03 wt%; 2-羥基-2-甲基-1-苯基-1-丙 鋼之重量百分比範圍可為0.388 wt%至0.773 wt%;笨 基雙（2, 4, 6-三甲基苯曱醯基）氧化膦之重量百分比範圍 可為0.039 wt%至0.155 wt%; 2-丙烯酸基-2-曱基 -1’ Γ _[ (9, 10-二氫-9, 10-二氧-1，4-蒽基）雙（亞胺 -4, 1-笨-2, 1-乙基）酯]之重量百分比範圍可為〇〇〇5 wt%至0. 〇2 wt%。 實施例2 :較佳實施例 為了使本領域之通常知識者能夠藉由此較佳實施例而可 據以實施，下文終將揭露本發明之高透氧隱形眼鏡之製 造方法的較佳實施例。需注意的是，以下本發明各成分 之數據，係為便於解釋本案技術特徵，並非為限制本發 明之態樣。 本較佳實施例中，首先係利用小粒徑之水溶性鹽（例如直 徑約為0. 03〜0. 05 μ m之氯化鈉與隱形眼鏡配方以49 :工 第10頁/共21頁 101單編號 A〇101 101200182卜0 201243427 [0032] Ο 均勻混合（不以此為限）’而所使用之隱形眼鏡配方的各 組分如下表1所示。 表1 成份 wt% 化合物1 0.45 化合物2 0.605 甲基丙烯酸羥乙酯 45 2-甲基-2-丙烯酸-2,3-二羥基丙酯 43 丙三醇 10 乙二醇二甲基丙烯酸酯 0.5 2-羥基-2-甲基-1-苯基-1·丙酮 0.4 苯基雙（2,4,6-三甲基苯甲醯基）氧化膦 0.04 2-丙烯酸基-2-甲基-l,l’-[(9,10-二氫-9,10-二氧-l，4-蒽基）雙（亞胺·4，l-笨-2,l-乙基） 酯] 0.005 [0033] ❾ [0034] 本發明之隱形眼鏡配方除了上述含量之外，亦可以下表2 所示之範例一或範例二的含量與水溶性鹽進行混合，混 合後的混合配方再進行铸模成型一隱形眼鏡β 表2 10110100#單編號 Α0101 第11頁/共21頁 1012001821-0 201243427 [0035] 水溶性鹽與表1所示之隱形眼鏡配方混合而得到混合配方 後’再將混合配方注入具有隱形眼鏡形狀之模具，並以 一般製造隱形眼鏡之程序製作，以形成一隱形眼鏡，如 第2圖所示。在第2圖中，可清楚辨識出隱形眼鏡包含有 許多鹽粒（第2圖中所圈選之處）。 稚W疋Ϊ不;谷欣（例如去離子水）水化上述隱形 眼鏡，將該隱形眼鏡内的水溶性鹽全部析出。當隱形眼 鏡中的水紐鹽被析出後，隱形眼制會留下複數個孔 隙，如第3圖中所圈選之處，而該些孔隙之大小係可透過 水溶性鹽㈣磨和M進行難。更詳細地說，水溶性 鹽可經由濃縮、_、粉碎、分級與賴或使用噴霧式 乾燥法（叩1^㈣61·)之步驟，使水溶性鹽之粒徑控制 在〇. 〇1至5 ”之間。較佳地，該些孔隙之大小約為 來使用鹽粒之直徑大小接近 單編號A_ 成份 範例一丨範例二 (wt%) (wt%) 化合物1 0.27 0.67 化合物2 0.81 0.90 甲基丙烯酸羥乙酯 45 ! 30 2-甲基-2-丙烯酸-2,3-二羥基丙酯 43 42 丙三醇 9 25.5 乙二醇二甲基丙烯酸酯 0.5 2-羥基-2-甲基-1-苯基-1-丙嗣 0.75 0.6 苯基雙（2,4,6-三甲基笨甲醯基）氧化 膦 0.15 0.1 2-丙烯酸基-2-甲基-1，1’-[(9，10-二氫 -9，l〇-二氧-i，4-葱基）雙(亞胺-4,卜笨 -2，1-乙基）醋1 0.02 0.005 101200: 第12頁/共21頁 201243427 ，表面與内部孔之隙的生成可增加氧氣交換的機會，因 此提高了隱形眼鏡之透氧率。 [0037] 而隱形眼鏡之透氧率的數據結果如下描述。其中，本實 施例係以屈光度-1. 0 0 D、_ 3. 5 0 D及-6. 5 0 D之隱形眼鏡 有無添加氯化鈉進行試驗，試驗組別共分成六組，組別1 至組別3係於製作時無添加氣化鈉，而組別4至6則有添加 氯化鈉（99 : 1)，如下表3所示。各組隱形眼鏡所測得之 透氧率如下表4、表5與第4圖所示。 [0038] 表 3 屈光度 有無添加氣化鈉 組別1 (n=4) -1.00D 無 組別2 (n=4) -3.50D 無 組別3 (n=4) -6.50D 無 組別4 (n=4) -1.00D 有 組別5 (n=4) -3.50D 有 組別6 (n=4) -6.50D 有 [0039]表 4 1011010(^單編號厕01 第13頁/共21頁 1012001821-0 201243427 透氧量（DK) 中心厚度（t) (cm) 透氧率（DK/t) 組別1 25.53 0.0141 18.11 24.99 0.0139 17.98 26.16 0.0145 18.04 25.92 0.0144 18.02 平均 19.62 標準差 0.1 組別2 17.16 17.16 18.06 16.83 16.83 17.90 16.47 16.47 17.90 17.52 17.52 18.06 平均 19.62 標準差 0.1 組別3 11.91 11.91 18.05 11.76 11.76 18.09 11.31 11.13 17.95 12.27 12.27 18.04 平均 19.62 標準差 0.1 [0040]表 5 10110100夢單編號 A0101 第14頁/共21頁 1012001821=0 201243427 透氧量（DK) 中心厚度（t) (cm) 透氧率（DK/t) 組別4 26.73 0.0136 19.65 26.88 0.0138 19.48 26.64 0.0134 19.88 26.85 0.0138 19.46 平均 19.62 標準差 0.1 組別5 17.94 0.0091 19.71 18.03 0.0092 19.6 17.88 0.0091 19.65 17.85 0.0091 19.62 平均 19.65 標準差 0.05 組別6 12.06 0.0062 19.45 12.27 0.0063 19.48 12.21 0.0063 19.38 12.57 0.0064 19.64 平均 19.49 標準差 0.11 [0041] 在表4與表5中，透氧量（〇9 Transmissibi i ty)係以DK 值表示（單位為[l〇_11 (cm3〇2*cm2/sec*cin3*nmHg])， 其中D為擴散係數（Diffusion)，表示氣體通過材料的擴 散能力，也就是氣體分子在物質中移動的速度；而K是溶 解係數（Solubility)，表示氧氣溶解於材料中的程度， 單編號删1 第15頁/共21頁 1012001821-0 201243427 在特定的壓力下，單位體積物質中能融解的氣體量。透 氧率（〇2 Permeability)則為透氧量/厚度（單位為 [10-11 (cm3〇9*cm/sec*cm3*ramHg])。In the contact lens formulation, the weight percentage of the compound 1 ranges from 0.001 wt% to 10 wt%, and the compound 2 can be mixed in a weight ratio of 0.001 wt% to 10 wt%. The weight percentage of hydroxyethyl methacrylate can range from wt.〇1 wt% to 99 wt%, and the weight percentage range of 2-mercapto-2-acrylic acid-2,3-dihydroxypropyl ester can be 〇. 〇1 wt% to 99 wt%, the weight percentage of glycerol may range from wt.〇1 wt% to 50 wt% 'ethylene glycol dimethacrylate, the weight percentage range may be 0.01 wt% to 30 The weight percentage range of wt%'2_starting base 2_methyl_1-phenyl-1 -acetone may range from 0.01 wt% to 10 wt%, stupid bis(2,4,6-trimethylbenzene) The weight percentage of the fluorinated phosphine oxide may range from 0.01 wt% to 10 wt%, 2-acryloyl-2-methyl-1, Γ-[(9, 10-dihydro-9, 10-dioxo) The weight percentage range of -1,4-mercapto)bis(imine-4, 1-benzene-2, 1-ethyl) ester can be from 〇. 0% by weight to 1% by weight. Preferably, the weight percentage of the compound 1 may range from 0.1 wt% to 2 wt%. The weight percentage of the compound 2 may be 0.1 wt% to 2 wt%. The weight percentage of hydroxyethyl methacrylate may be 20 wt% to 55 wt%, and the weight percentage of 2-methyl-2-acrylic acid-2,3-dihydroxypropyl ester may range from 37 wt% to 48 wt%, The weight percentage of the triol may range from 1 wt% to 35 wt% 'glycol dimercapto acrylate. The weight percentage may range from 0.01 wt% to 10 wt% '2-hydroxy-2-mercapto-1-benzene The weight percentage of ketone-1-acetone may range from wt. 1 wt% to 1.5 wt%, and the weight percentage of bis(2,4,6-trimethylbenzylidene)phosphine oxide may be 0.01. Wt% to 1 wt% '2-acryloyl-2-methyl-1,1,-[(9, 10-dihydro-9, 10-dioxo-1,4-indenyl) bis (imine- 4, benzene 10110100^ single number A0101 page 9 / 21 pages 1012001821-0 201243427 -2, 1-ethyl) ester] weight percentage range can be 〇. 〇〇1 wt%si Wt% 〇 [0028] [ [0031] The weight percentage of Compound 1 may range from 262. 6% to 0.69 wt%, and the weight percentage of Compound 2 may be from 0.587 wt% to 972 972 wt%. The weight percentage of hydroxyethyl methacrylate may range from 29.1 wt% to 46.35 wt%; the weight percentage of 2-mercapto-2-acrylic acid-2,3-dihydroxypropyl vinegar may range from 40.74 wt% to 44.29 wt%. The weight percentage of glycerol may range from 8.73 to 26 265 wt%; the weight percentage of ethylene glycol dimercapto acrylate may range from 0.485 wt% to 1.03 wt%; 2-hydroxy-2-methyl- The weight percentage of 1-phenyl-1-propene steel may range from 0.388 wt% to 0.773 wt%; the weight percentage of stupidyl bis(2,4,6-trimethylphenylnonyl)phosphine oxide may range from 0.039 Wt% to 0.155 wt%; 2-acrylic-2-mercapto-1' Γ _[(9, 10-dihydro-9, 10-dioxo-1,4-mercapto) bis (imine-4重量重量重量。 The weight percentage of ,5 wt% to 0. 〇 2 wt%. Embodiment 2: Preferred Embodiments In order to enable a person of ordinary skill in the art to implement the preferred embodiments, a preferred embodiment of the method for manufacturing a high oxygen permeability contact lens of the present invention will be disclosed hereinafter. . It is to be noted that the following data of the components of the present invention are for the purpose of explaining the technical features of the present invention and are not intended to limit the aspects of the present invention. In the preferred embodiment, firstly, a water-soluble salt having a small particle size (for example, a sodium chloride and a contact lens formulation having a diameter of about 0.03 to 0.05 μm) is used. 49: 10th page/total 21 pages 101 single number A 〇 101 101200182 卜 0 201243427 [0032] 均匀 uniform mixing (not limited to this) 'The components of the contact lens formulation used are shown in Table 1. Table 1 Component wt% Compound 1 0.45 Compound 2 0.605 hydroxyethyl methacrylate 45 2-methyl-2-acrylic acid-2,3-dihydroxypropyl ester 43 glycerol 10 ethylene glycol dimethacrylate 0.5 2-hydroxy-2-methyl-1 -phenyl-1·acetone 0.4 phenylbis(2,4,6-trimethylbenzylidene)phosphine oxide 0.04 2-acryloyl-2-methyl-l,l'-[(9,10- Dihydro-9,10-dioxo-1,4-mercapto)bis(imine·4,l-stup-2,l-ethyl)ester] 0.005 [0033] The contact lens of the present invention In addition to the above content, the formula may also be mixed with the water-soluble salt according to the content of the first or second example shown in Table 2, and the mixed formula after molding is molded into a contact lens β. Table 2 10110100#单号Α0101 11 pages / total 21 pages 1012001 821-0 201243427 [0035] The water-soluble salt is mixed with the contact lens formulation shown in Table 1 to obtain a mixed formulation, and then the mixed formulation is injected into a mold having a contact lens shape, and is produced by a general procedure for manufacturing a contact lens to form A contact lens, as shown in Figure 2. In Figure 2, it can be clearly seen that the contact lens contains a lot of salt particles (the circled in Figure 2). Deionized water) hydrates the above contact lens, and completely precipitates the water-soluble salt in the contact lens. When the water salt in the contact lens is precipitated, the invisible eye system leaves a plurality of pores, as shown in FIG. Circled, and the size of the pores is difficult to pass through the water-soluble salt (4) mill and M. In more detail, the water-soluble salt can be concentrated, _, pulverized, classified, and sprayed using a spray drying method (叩1^(4)61·), the particle size of the water-soluble salt is controlled between 〇1 and 5 ”. Preferably, the size of the pores is approximately the diameter of the salt particles used to approximate the single number A_ Example of a sample Example 2 (wt%) (wt%) 1 0.27 0.67 Compound 2 0.81 0.90 Hydroxyethyl methacrylate 45 ! 30 2-Methyl-2-acrylic acid-2,3-dihydroxypropyl ester 43 42 Glycerol 9 25.5 Ethylene glycol dimethacrylate 0.5 2 -hydroxy-2-methyl-1-phenyl-1-propanthene 0.75 0.6 phenyl bis(2,4,6-trimethyl benzoyl) phosphine oxide 0.15 0.1 2-acryloyl-2-methyl -1,1'-[(9,10-dihydro-9,l〇-dioxo-i,4-onionyl) bis(imine-4, bucci-2,1-ethyl) vinegar 1 0.02 0.005 101200: Page 12 of 21 201243427, the formation of the gap between the surface and the internal pores increases the chance of oxygen exchange, thus increasing the oxygen permeability of the contact lens. [0037] The data results of the oxygen permeability of the contact lens are described below. In this embodiment, the contact lenses with diopter-1. 0 0 D, _ 3. 5 0 D and -6.50 D are tested with or without sodium chloride, and the test groups are divided into six groups, group 1 To group 3, no sodium carbonate was added at the time of production, and sodium chloride (99:1) was added to groups 4 to 6, as shown in Table 3 below. The oxygen permeability measured by each group of contact lenses is shown in Table 4, Table 5 and Figure 4 below. Table 3 diopter with or without added gasification sodium group 1 (n=4) -1.00D no group 2 (n=4) -3.50D no group 3 (n=4) -6.50D no group 4 (n=4) -1.00D with group 5 (n=4) -3.50D with group 6 (n=4) -6.50D There are [0039]Table 4 1011010 (^单单厕01 Page 13 / Total Page 21 1012001821-0 201243427 Oxygen Permeability (DK) Center Thickness (t) (cm) Oxygen Permeability (DK/t) Group 1 25.53 0.0141 18.11 24.99 0.0139 17.98 26.16 0.0145 18.04 25.92 0.0144 18.02 Average 19.62 Standard Deviation 0.1 Group 2 17.16 17.16 18.06 16.83 16.83 17.90 16.47 16.47 17.90 17.52 17.52 18.06 Average 19.62 Standard deviation 0.1 Group 3 11.91 11.91 18.05 11.76 11.76 18.09 11.31 11.13 17.95 12.27 12.27 18.04 Average 19.62 Standard deviation 0.1 [0040] Table 5 10110100 Dream list number A0101 Page / Total 21 pages 1012001821=0 201243427 Oxygen Permeability (DK) Center Thickness (t) (cm) Oxygen Permeability (DK/t) Group 4 26.73 0.0136 19.65 26.88 0.0138 19.48 26.64 0.0134 19.88 26.85 0.0138 19.46 Average 19.62 Standard Deviation 0.1 group 5 17.94 0.0091 19.71 18.03 0.0092 19.6 17.88 0.0091 19 .65 17.85 0.0091 19.62 Average 19.65 Standard deviation 0.05 Group 6 12.06 0.0062 19.45 12.27 0.0063 19.48 12.21 0.0063 19.38 12.57 0.0064 19.64 Average 19.49 Standard deviation 0.11 [0041] In Tables 4 and 5, the oxygen permeability (〇9 Transmissibi i ty ) is expressed in DK (unit: [l〇_11 (cm3〇2*cm2/sec*cin3*nmHg]), where D is the diffusion coefficient (Diffusion), indicating the ability of the gas to diffuse through the material, that is, the gas molecule The rate of movement in the substance; and K is the solubility coefficient (Solubility), indicating the degree to which oxygen is dissolved in the material, single number deletion 1 Page 15 / 21 pages 1012001821-0 201243427 Under a specific pressure, in a unit volume of matter The amount of gas that can be melted. The oxygen permeability (〇2 Permeability) is the oxygen permeability/thickness (unit: [10-11 (cm3〇9*cm/sec*cm3*ramHg]).
UU
[0042] 如表4、表5及第4圖所示，相對於組別1、組別2與組別3 ，組別4、組別5及組別6之透氧率分別增加8. 76%、 9. 26%及8. 07%。也就是說，本發明之製造過程中將氯化 鈉與具親水性單體之隱形眼鏡配方相混合，在鑄模成型 為隱形眼鏡後水化、析出氯化鈉，進而得到表面及内部 具有複數個孔隙的隱形眼鏡，而所得的隱形眼鏡確實可 增加其透氧率。 [0043] 綜上所述，在本發明之高透氧隱形眼鏡之製造方法中， 隱形眼鏡上的孔隙係藉由人體可分解之水溶性鹽與具親 水性單體之隱形眼鏡配方相混合後，再析出水溶性鹽而 形成。因此，相對於傳統方法，本發明之隱形眼鏡可依 需求調整水溶性鹽之配方比例與粒徑大小，以產生具有 較多且較大之孔隙，即可達到增加透氧率之功效，進而 可有效避免角膜缺氧之問題。 [0044] 以上所述僅為舉例性，而非為限制性者。任何未脫離本 發明之精神與範疇，而對其進行之等效修改或變更，均 應包含於後附之申請專利範圍中。 【圖式簡單說明】 [0045] 第1圖係為本發明之高透氧隱形眼鏡之製造方法之一實施 例之流程圖。 第2圖係為本發明隱形眼鏡水化前之顯微鏡示意圖。 第3圖係為本發明隱形眼鏡水化後之顯微鏡示意圖。 1Λ1〇ΛΑ1〇Γ>1 Λ 丄 υΙΖυυιό 乙 Ji-u 10110100#單編號A〇101 第16頁/共21頁 201243427 第4圖係為藉由添加氯化鈉所製得之隱形眼鏡與無添加氣 化鈉所製得之隱形眼鏡的透氧率關係柱狀圖。 【主要元件符號說明】 [0046] S11 〜S13 :步驟 單編號 A0101 第17頁/共21頁 1012001821-0[0042] As shown in Table 4, Table 5, and Figure 4, the oxygen transmission rates of Group 1, Group 2, and Group 3, Group 4, Group 5, and Group 6 increased by 8.76, respectively. %, 9.26% and 8.07%. That is to say, in the manufacturing process of the present invention, sodium chloride is mixed with a contact lens formulation having a hydrophilic monomer, and after being molded into a contact lens, the sodium chloride is hydrated and precipitated, thereby obtaining a plurality of surfaces and interiors. Contact lenses in the pores, and the resulting contact lenses do increase their oxygen permeability. [0043] In summary, in the method for manufacturing a high oxygen permeability contact lens of the present invention, the pores on the contact lens are mixed with a water-soluble salt decomposable by a human body and a contact lens formulation having a hydrophilic monomer. And formed by precipitation of a water-soluble salt. Therefore, compared with the conventional method, the contact lens of the present invention can adjust the formula ratio and the particle size of the water-soluble salt according to the demand, so as to produce more and larger pores, thereby achieving the effect of increasing the oxygen permeability, and further Effectively avoid the problem of corneal hypoxia. [0044] The foregoing is illustrative only and not limiting. Any equivalent modifications or alterations to the spirit and scope of the invention are intended to be included in the scope of the appended claims. BRIEF DESCRIPTION OF THE DRAWINGS [0045] Fig. 1 is a flow chart showing an embodiment of a method for producing a high oxygen permeability contact lens of the present invention. Figure 2 is a schematic view of the microscope before the hydration of the contact lens of the present invention. Figure 3 is a schematic view of the microscope after the hydration of the contact lens of the present invention. 1Λ1〇ΛΑ1〇Γ>1 Λ 丄υΙΖυυιό BJi-u 10110100#单号A〇101 Page 16 of 21201243427 Figure 4 is a contact lens made with sodium chloride added and no added gas A histogram of oxygen permeability relationship of contact lenses prepared by sodium. [Explanation of main component symbols] [0046] S11 to S13: Step No. A0101 Page 17 of 21 1012001821-0