TW201221153A - Dental care product - Google Patents

Abstract

A dental care product comprises an orally acceptable carrier or excipient, and a bacterial resistance copolymer, which comprises a zwitterionic block and a charged anchoring block, wherein the anchoring block binds to tooth surfaces by electrostatic attraction, and the zwitterionic block extends outwardly to reduce the attachment of bacteria to tooth surfaces.

Description

201221153 VI. Description of the Invention: [Technical Field to Which the Invention Is Applicable] [0001] The present invention relates to a dental health care product having a highly antibacterial effect. [0002] * The present invention is a U.S. Patent Application Serial No. 1 2/953, 036, filed on November 23, 2010, entitled "Dental care product": U.S. Patent Application, Application No. 12/952, 91 3. Application 11 November 23, 2010, entitled “Surface anti-biomolecule agent”; and, US Patent Application, Application No. 12/953, 110, Application Date November 23, 2010, entitled “Biocarrier The related application of the method and using the same, the entire contents of which are hereby incorporated herein by reference in its entirety in the entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire all There are several factors that cause tooth decay. It is widely believed in the medical community that dental plaque (dental piaqu.e) is the main cause of bad tooth history. Plaque is a usually colorless biofilm formed by bacteria that are propagated on teeth, deposited saliva proteins, and food debris. Plaque can cause dental calculus, gingivitis, and other dental silver diseases. In addition, in plaque, Streptococcus mutans converts sugar into an organic acid, which releases hydrogen ions under the surface of the tooth enamel, causing the enamel to diffuse calcium ions and phosphate ions, causing teeth. [0004] Dental care products for eliminating bad breath and sterilization, such as mouthwashes, toothpastes, tooth powders, etc., have been used for over one hundred years. Some antibacterial 100101362 Form No. A0101 Page 3 / Total 35 pages 1002002410-0 201221153 Mouthwash 'List er er i ne®, using essential oils such as thymol, thiol Methyl salicylate 'menthol' with eucalyptol and the like as an active ingredient. In addition, 'mouthwashing usually uses alcohol (&1(:〇1)〇1) as a solvent for the active ingredient, and dissolves essential oils and/or other ingredients with a surfactant. In addition, other effective antimicrobial agents such as hexagram Cetyl pyridinum chloride (CPC), chlorhexidine gluconate, hydrogen peroxide, benzoic acid, phenolic compounds, and fluoride ( Fluoride, etc. are also often used as the main component of mouthwash. [0005] [0007] [0007] 100101362 Research has found that many of the above active ingredients may be discounted due to the presence of surfactants, and some ingredients may harm the human body. Therefore, there is a need in the art to develop a more complete and effective dental care product. .... 〇:; 匕V: [Summary of the Invention] The present invention relates to dental care with a high antibacterial effect. An embodiment of the present invention provides a dental care product comprising an orally acceptable carrier or adjuvant, and a first antibacterial having a concentration above 01 mg/ml. The antibacterial copolymer comprises a double ionic block and a tethered block having a first electrical property, wherein the anchoring segment is bonded to a tooth surface by electrostatic attraction, the diionic block orientation Externally extending to reduce the adhesion of bacteria to the surface of the tooth. Another embodiment of the invention provides a two-part dental care product, 1002002410-0, early in the morning, A0101, page 4, total 35 pages [0008] 201221153 contains the first dose And a second agent. The first agent comprises an orally acceptable first carrier or adjuvant, and a first antimicrobial copolymer having a concentration of 0.1 mg/ml or more, comprising a first diionic block and a a first tying block having a first electrical property, wherein the first tying block is bonded to a tooth surface by electrostatic attraction, the first ionic block extending outward to reduce bacterial adhesion to the a second surface comprising an orally acceptable second carrier or adjuvant, and a second antimicrobial copolymer having a concentration above 1 mg/ml, comprising a second diionic block and a第二 a second electrical block with a second electrical property, wherein The second electrical property is opposite to the first electrical electrical property, the second tying dance segment is coupled to the tooth surface by electrostatic attraction, and the second dual ionic block extends outward to reduce bacterial adhesion to the [Embodiment] [0009] The embodiments of the present invention will be described in detail below with reference to the drawings. Ο In addition to the detailed description, the present invention can be widely applied to other embodiments, any Easily substituted, modified, and equivalent changes of the embodiments are included in the scope of the present invention, and the scope of the following patents will prevail. In the description of the specification, in order to make the reader more complete, *1, the present invention may be implemented by omitting some or all of the pure details (4). In addition, steps or elements that are well known in the art are not described in detail to avoid unnecessarily limiting the present invention; the number of each of the 7C elements of the present invention may be more or less than [0010] unless otherwise limited. Oral bacteria are the main cause of bad breath and cause dental calculus and plaque in teeth and gums. Traditional dental health products use essential oils 100101362 Form No. A0101 Page 5 of 35201221153 or antibacterial agents to eliminate bacteria. Different from the prior art, the dental health care product provided by the present invention has an ultra-high anti-bacterial effect, and, surprisingly, this amazing effect can be achieved without using a conventional antibacterial agent or essential oil. . In addition, the dental care product provided by the embodiment of the present invention does not cause harm to humans. [0011] An embodiment of the present invention provides a dental care product comprising at least an orally acceptable carrier or excipient, and an antimicrobial resistance having a concentration of 0.1 mg/mL or more (bacterial resistance) Copolymer) 5 wherein an antibacterial copolymer is used as a main component. [0012] The above antibacterial copolymer comprises a zwitterionic block and an anchoring block having a first electrical property. In this embodiment, the tie block can be positively or negatively charged, i.e., the first electrical property can be positive or negative. The tie block essentially consists of a positively charged monomer or a negatively charged monomer. Wherein the positively charged monomer may be selected from one or a combination of the following groups: 100101362

Form No. A0101 Page 6 of 35 1002002410-0 201221153

❹

Ο

Further, the negatively charged monomer may be selected from one or a combination of the following groups: 100101362 Form number Α 0101 Page 7 of 35 1002002410-0 201221153

The first figure shows the antibacterial mechanism of the antibacterial copolymer according to the above embodiment of the present invention. The surface of the human tooth should be a naturally mixed surface. According to this feature, the tying block of the embodiment of the present invention utilizes electrostatic attraction to bond the surface of the tooth, while the diionic block extends outward to reduce bacteria, including S. subtilis, and adhere to the tooth surface. It is to be noted that the above-mentioned antibacterial mechanism is only a theory, and the implementation of the dental care product of the present invention may not be limited to the above theory. Further, the above-mentioned diionic block is formed by polymerization of a double ionic monomer. The above diionic monomer is one or a combination selected from the group consisting of thio beet test (3111 {〇56士3丨1!6), carboxylbetaine, and the aforementioned two monomers. Derivatives, any combination of the foregoing. In one embodiment, the diionic monomer is one or a combination of the following groups: 100101362 Form No. A0101 Page 8 of 35 1002002410-0 201221153

100101362 Form No. A0101 Page 9 of 35 1002002410-0 201221153 Edition Corpse 3

SC 〇 D D D K 't t%2. K3- , N+〆, _▲, or neighboring 作 Η Η\

H2G

ϊ r3 \\ /, (c_ o and 100101362 Form No. A0101 Page 10 of 35 1002002410-0 201221153

S [0016] wherein S, R2, R3, R4, and R5 are alkyl groups, and η and m are each a positive integer of 2 to 5. In another embodiment of the present invention, the above diionic block may be polymerized using a double ionic unit, and the diionic unit comprises a thirsty charge monomer comprising two compounds of opposite electrical properties (including Any of the foregoing positively charged and negatively charged monomers), but: the sound is in the middle of the belt. [0017] Preferably, the aforementioned anti-bacterial copolymer has a weight average molecular weight (Μ) equal to or w greater than 15 kDa. The weight average molecular weight of the above-mentioned diionic block is equal to or greater than 10 kDa. The above dental care product provided by the present invention may be of the following types, such as dentifrice, toothpaste, mouthwash, pro-rinse, denture cleaning agent, etc. Etc. Among them, mouthwash is preferred. In addition, if necessary, the above dental care products can be formulated into powders, gels, foams, pastes, and mouths using standard known formulations. Form No. A0101 Page 11 of 35 pages 1002002410-0 201221153 Sugar, rich (four) green 'in the form of money. If it is formulated into a spin shape, the user may first dissolve the tooth pure (10) in water before use [0018] [0020] Another embodiment of the present invention provides a dental care product having two formulations. Containing - the first agent and the second agent. The ingredients of both of them are the same as the above, except that the agent is positively charged in the latter part and the blocking block of the other agent is negatively charged. The above-mentioned first and second agents can be separately stored in two containers to be used in sequence. Time ❹ _ order, or any order can be. In the two previous embodiments of the present invention, a dental care product having two doses has a better antibacterial effect than a health care product in a single dose. The copolymer of the present invention is preferably a block copolymer (bi〇ck c〇_polymer), such as a diblock copolymer (dibl〇ck c〇p〇lymer, as shown in the first figure), three inlays Segmental polycondensate (tribl〇ck c〇p〇ly_ mer), multi-segmented copolymer (multibi〇ck c〇p〇lymer), star-shaped ... (.starblock cojiblymer), and grafting Graft block copolymer and the like. Alternatively, the copolymer of the present invention may be a random copolymer (rand〇fll c〇p〇iymer), a branched polymer 'gradient copolymer, and the like. Some of these other forms of copolymers are disclosed in the aforementioned U.S. Patent Application, rSurface anti-biomolecule agent, the entire disclosure of which is incorporated herein by reference. As long as the anti-bacterial mechanism as shown in the first figure is utilized, the above various forms of copolymers are believed to achieve the same 100101362 Form No. A0101 Page 12/35 pages 1002002410-0 201221153 [0021] 抗 [0022] Bacterial effect. In the embodiments of the present invention, the carrier for transporting the active ingredient is substantially an aqueous medium, and may comprise water, a mixture of water and a surfactant, a water/surfactant/solvent mixture, or the like, and the like. . The carrier used in the dental care product of the present invention may be free of alcoholic ingredients Calcohol-free). Surfactants may be used to increase the solubility of some ingredients, such as flavoring 〇ils. Any food grade surfactant that can be ascertained by those skilled in the art can be utilized in the various embodiments of the present invention. Preferably, the dental care product of the present invention uses a nonionic: (n〇n_i〇nic) surfactant which is added in an amount sufficient to dissolve the component to be dissolved. The dental health care product of the above embodiment of the present invention, It is possible to have a high antibacterial effect without using any essential oil or antibacterial agent. Although it is not necessary, the dental care product in other embodiments of the present invention may contain essential oils or antibacterial agents. Antibacterial agents that may be used include triclosan, cetyl pyridium chloride, dodecyl-dimethyl-2-phenoxy-ethylamine bromide (domiphen bromide, quaternary ammonium salts, zinc compounds, sanguinarine soluble pyrophosphates, fluorides, alexidine (alexidine), ethylenediaminetetraacetic acid (EDTA). In addition, the dental care product of the embodiment of the present invention may include other formula additives frequently used in conventional oral care products, such as flavouring agents, sweeteners 100101362, Form No. A0101, page 13 if necessary. / Total 35 pages 1002002410-0 [0023] 201221153 (sweetening agents), colouring agents, thickening agents, humectants, softeners, preservatives, etc. . The requirements for these additional ingredients must be compatible with the active ingredients of the embodiments of the invention, and the premise of addition is to achieve a particular purpose or efficacy. Those skilled in the art will be able to opt in and formulate appropriate ratios based on the desired results. Example [0025]

Table 1 lists the characteristics of the nine antifungal copolymers prepared by the examples of the present invention. These nine copolymers can be divided into three major categories: (1) block copolymers having a hydrophobic block (as a tie block) and a double ionic block, such as poly(propylene oxide), PP0 a block copolymer (PPO-b-PSBMA) with poly(sulfobetaine methacrylate (PSBMA)); with a positively charged block and a double ionic block Ruthenium copolymer, such as polymethacryloyloxyethyltrimethylammonium vapor

(poly(l1-mercapto-N, N, N trimethyl ammonium)

Chloride, PTMA) and polystyrene beet acrylate (PSBMA) as a bulk copolymer (PTMA-b-PSBMA); (3) block copolymer with a negatively charged block and a double ionic block For example, a block copolymer (PSA-b-PSBMA) of poly(11-mercaptoundecy 1 sulfonic acid), PSA] and polythiobetaine acrylate (PSBMA). The above nine copolymers can be prepared by atom transfer radical polymerization (ATRP) to prepare a sample of various monomer repeats, but not 100101362 Form No. A0101 Page 14 of 35 1002002410-0 201221153 Limited this. Table 1 Sample ID Copolymer Properties PSBMA Content Monomer Quantity Zeta Potential Hydraulic Diameter Mw (g/mol) Mw of poly Mw of PSBMA (wt%) (mol%) mn 1 mg/ml 1 mg/ml PP〇20-b -PSBMA10 3952 1.267 1057 2S95 73.3 33.3 20 10 •0.2 ～10 PPOo-b-PSBMAzo 6038 1.217 1057 4981 82.5 47.4 20 18 -0.5 ～10 PP020-b-PSBMA4〇12775 1.236 1057 11718 91.7 67.7 20 42 +0.7 〜11 PTMA20 -b-PSBMA10 7765 1.214 4596 3169 40.8 33.3 22 11 +1.4 ~10 PTMA^b-PSBMAa, 10176 1.435 4596 5592 55.0 47.6 22 20 +3.2 ~10 PTMA2〇-b-PSBMA4〇16158 1.312 4596 11562 71.6 65.1 22 41 + 4.3 ~13 PSA2〇-b-PSBMA|〇7750 1.207 5060 2690 34.7 32.3 21 10 -0.9 ~10 PSA2〇-b-PSBMA2〇10620 1346 5060 5660 53.3 48.8 21 20 -2.8 ~11 PSA2〇-b-PSBMA4〇15202 1.287 5060 10142 66.7 63.2 21 36 -3.7 ~12 第二 [0026] The second figure shows a laboratory test plan for the preparation of nine copolymers in accordance with an embodiment of the present invention. First, test solutions were prepared separately, each of which contained a copolymer listed in Table 1. After the lapse of the test, the antibacterial effect of the various test solutions is checked after a period of time. The test solutions prepared can be classified into four types: first type, first type, third type, and fourth type. The first type ear type third solution is the above single-form type solution, and PPO-b-PSBMA (1), PSA-b-PSBMA (2), and ρτΜΑ_ b-PSBMA (3) are respectively used as active ingredients. The fourth type of solution is the aforementioned two dosage form

Solution, two doses of PTMA-b-PSBMA (3) and PSA-b-PSBMA (2) as active ingredients; in the test 'take a disc or disc of human real teeth' in a predetermined order first immersed After one of the doses, it is immersed in another dose for a while. It is also shown in the figure that the prepared copolymer will adhere to the surface of a hydroxyapatite disc or human real tooth in a self-assembled manner, including hydrophobic interaction and electrostatic attraction. Since both the second and third types are single-dose solutions, 100101362 1002002410-0 Form No. A0101 Page 15 of 35 201221153 There may be electrostatic mutual repulsion between the anchoring blocks of the copolymer. In contrast, when two surfaces of the fourth type solution are coated on the surface of a light limet disc or a human real tooth, there should be an electrostatic attraction between the anchoring blocks of the copolymer. [0028] The third figure shows the adhesion test of the type 4 solution prepared in the examples of the present invention. For the preparation of the first, second, and third types of solutions, each of the foregoing copolymers is dissolved in phosphoric acid at different molecular weights and concentrations, from 〇1 „^/1 „1 to 1 mg/ml. In salt buffer saline 'PBS. A light apatite disk was placed in the test solution during the test to observe the adhesion of each copolymer. The higher adhesion of the copolymer indicates that the copolymer solution has a better adhesion to the surface of the limestone. For the preparation of the fourth type of solution, PSA^-b-PSBMA盥PTMA20-b-PSBMA4() was dissolved in the two groups of the buffer solution at a concentration of 1 mg/ml as a two-part dental care product. Two doses. To observe the effect of the two-use sequence, sample (a) is a monohydroxyapatite disc,

After coating PSA-b-PSBMA, 'recoat PTMA-b-PSBMA 乙 u 4υ L 〇4〇; sample (b) is another hydroxyapatite round Μ, first coated ΡΤΜΑ - 20 b-PSBMA After that, PSA9n-b-PSBMA was coated. 40 2 U 40 As shown in the third figure, 'For the hydroxyapatite surface, the first type of solution shows poor adhesion; the second and third types of solutions show that except for the concentration of 0 · 01 mg/m 1 The samples all have good adhesion; the fourth type of solution shows that both samples have excellent adhesion regardless of which one is applied first. Because protein deposition on the tooth surface can help oral bacteria cause various dental diseases, a good dental care product should provide good 100101362 Form No. A0101 Page 16 of 35 1002 [0029] 201221153 Anti-protein adsorption capacity. The fourth figure shows a four-form solution prepared according to an embodiment of the present invention, and a comparative sample comprising single protein adsorption of polystyrene (PS), hydroxyapatite (HA), Li Shi Delin mouthwash, PSBM A gel, and the like. The test, in which the four types of solution were prepared as described above, but the concentration of the copolymer was fixed at j mg/ml. [0030] In the test, each test solution was immersed in a hydroxyapatite disk, and the active ingredient in the solution was coated on the surface of the disk. The hydroxyapatite disc is then contacted with a human plasma fibrin solution to assess the anti-protein adsorption capacity of the test solution. The protein adsorption data of all test solutions were normalized to the protein adsorption data of the HA surface without antibacterial treatment. The experimental results show that the surface of the HA treated with the first type of solution has a similar protein adsorption amount to the surface of the BA which has not been treated with antibacterial treatment. The HA surface treated with the second type solution or the third type solution has an acceptable anti-protein adsorption ability. The surface of the HA treated with the fourth type solution has superior anti-protein adsorption capacity than the surface of the HA treated with the Li Shi Delin mouthwash. Q [0031] The fifth to fifth E and sixth arrows show the 4 plastic solution prepared in the examples of the present invention, and the comparative sample 'comprises polystyrene (PS), hydroxyapatite (HA), and Li Shi Delin Bacterial coverage test of saliva, PSBMA glue, etc., wherein the fifth A to fifth E pictures are photographs after the bacterial coverage test, and the sixth figure is the data data of the fifth A to fifth E pictures. A plurality of petrophyte discs were individually passed through a first to fourth type solution, a Li Shi Delin mouthwash, and a PSBMA gel, and treated with the human sputum for 72 hours as the surface bacteria were treated as described above. Coverage rate is evaluated for its antibacterial ability. Human saliva has S. mutans, which will form a biofilm on the surface of the hydroxyapatite disc 100101362 Form No. A0101 Page 17 of 352002410-0 201221153, and the coverage ratio of this biofilm can be used to evaluate the test solution. The antibacterial ability of the active ingredients in the medium. Images and data on the surface of the hydroxyapatite disc were recorded after 3 hours, 24 hours, and 72 hours of contact with saliva. All experimental procedures were performed under conditions equivalent to human physiology. In addition, the biofilm coverage of the HA surface without any antibacterial treatment was used as a comparative reference surface in which the (green) spotted shape was located where the biofilm was located. Compared to the surface of the HA which has not been treated with antibacterial treatment, all of the surface of the HA treated with the first type of solution exhibits only a slight antibacterial ability regardless of the molecular weight of the copolymer contained in the solution. The HA surface treated with the second type solution showed good antibacterial ability except for the sample number PSA2()-b-PSBMA1(), which indicates the active ingredient of this type of dental care solution, and its diionic block. The molecular weight should be close to or greater than the molecular weight of the tied block. The HA surface treated by the third type solution showed that the third type solution had slightly better antibacterial ability than the second type solution; after 3 hours and 24 hours of the test time, the HA surfaces after the treatment of the three third type solutions were all Shows good antibacterial ability. It has also been observed from the experimental results that the PSBMA sample solution having a higher molecular weight has better antibacterial ability. The surface of the HA treated with the solution of the fourth type showed that the fourth type solution had excellent antibacterial ability, and the sample (a) was superior to the sample (b). For the sample (a), no biofilm appeared after 3 hours of the test time, and the bacterial coverage after 72 hours of the test time was less than 3%. For sample (b), biofilm did not appear after 48 hours of test time, and microbial coverage did not occur until 72 hours after the test time. On the HA surface after the treatment of the sample sample Li Shi Delin mouthwash, a small amount of bacterial coverage appeared after 3 hours of test time, test time 100101362 Form No. A0101 Page 18 / Total 35 Page 1002002410-0 201221153 [0033] Ο [0034] Ο [0036] The bacterial coverage after 24 hours increased to about 10%, and the bacterial coverage after 48 hours of the test time increased to about 60 〇/〇. Figures 7 and 8 show bacterial coverage tests similar to the fifth to fifth and sixth, except that the subject is replaced by a hydroxyapatite (ΗΑ) disc that simulates the teeth. tooth. The seventh figure is a photograph of the dental care solution prepared in the examples of the present invention after applying the dental care solution prepared in the examples of the present invention. The eighth figure shows the data of the seventh figure. Since human real teeth are difficult to obtain, for the second type solution and the third type solution, only one copolymer sample is selected for testing, and the first type solution is removed. Similarly, the surface of a human tooth that has not been treated with any active ingredient is used as a reference surface. '...' As shown in the seventh and eighth figures, the test solution containing pSA _pSBM pc υ 4 0 MA2 (Tb_PSBMA4〇 showed an antibacterial ability comparable to that of Li Shi Delin mouthwash. Whether it is sample (a) or sample (b), both show an antibacterial ability superior to Li Shi Delin mouthwash. The above experimental data shows that the dental care solution provided by the embodiment of the present invention has comparable or even superior quality to the commercially available product Lee. The antibacterial ability of the Sterling Mouthwash is only the preferred embodiment of the present invention, and is not intended to limit the scope of the present invention; any equivalent changes or modifications made without departing from the spirit of the invention. All of them should be included in the scope of the following patent application. [Simple Description of the Drawings] 100101362 Form No. A0101 Page 19/35 pages 1002002410-201221153 [0037] The first figure shows an antibacterial copolymer according to an embodiment of the present invention. Antibacterial mechanism, the second figure shows a laboratory test plan for preparing nine copolymers according to an embodiment of the present invention, and the third figure shows the preparation of the examples of the present invention. The adhesion test of the type solution; the fourth figure shows the single protein adsorption test of the four type solution prepared according to the embodiment of the present invention; the fifth to fifth E pictures are coated on the port of the hydroxyl apatite After the dental care solution prepared in the embodiment of the present invention, the photograph after the bacterial coverage test is performed; the sixth figure shows the data of the fifth A to the fifth E; and the seventh figure is the application of the present invention on the human tooth. After the dental care solution prepared in the example, the photograph after the bacterial coverage test is performed; the eighth figure shows the data of the seventh figure. [Main component symbol description] [0038] None. 100101362 Form No. A0101 Page 20 of 35 1002002410-0

Claims (1)

201221153 VII. Patent application scope: 1. A dental health care product comprising: an orally acceptable carrier or adjuvant; and a first antimicrobial copolymer having a concentration above 0.1 mg/ml, comprising a double ionicity a block and a tie block having a first electrical property, wherein the tie block is bonded to a tooth surface by electrostatic attraction, the double ion block extending outward to reduce bacterial adhesion to the tooth surface . 2. The dental health care product of claim 1, wherein the first electrical property is positive. 〇 3. The dental health care product of claim 1, wherein the first electrical property is negative. 4. The dental health care product of claim 1, wherein the diionic block is polymerized using a double ionic monomer selected from one of the group consisting of: Sulfobetaine, carboxylbetaine, derivatives of the above two monomers, any combination of the foregoing. 5. The dental health care product of claim 1, wherein the diionic 0 block is polymerized using a double ionic unit, and the dual ionic unit comprises a mixed charge monomer comprising two types of electricity The opposite compound, but overall neutral. 6. The dental health care product of claim 1, wherein the first antimicrobial copolymer has a weight average molecular weight of 15 kDa or more. 7. The dental health care product of claim 1, wherein the diionic block has a weight average molecular weight of 10 kDa or more. 8. A dental care product according to claim 1 of the patent scope, wherein the dental care 100101362 Form No. A0101 Page 21 / Total 35 pages 1002002410-0 201221153 The type of the product comprises tooth powder, toothpaste, mouthwash, tooth pre-washing agent, Denture cleaner. 9. A two-part dental care product comprising: a first agent comprising: an orally acceptable first carrier or adjuvant; and a first antimicrobial copolymer having a concentration above 0.1 mg/ml, comprising - a first dual ionic block and a first tying block having a first electrical property, wherein the first tying block is bonded to a tooth surface by electrostatic attraction, the first dual ionic block Externally extending to reduce the adhesion of bacteria to the surface of the tooth» a second agent comprising: an orally acceptable second carrier or adjuvant; and a second antimicrobial copolymer having a concentration of greater than 0.1 mg/ml, The second ionic block and a second tying block having a second electrical property, wherein the second electrical property is opposite to the electrical property of the first electrical property, and the second tying block is An electrostatic attraction is combined with the tooth surface, and the second diionic block extends outward to reduce bacterial attachment to the tooth surface. 10. The dental health care product of claim 9, wherein the first electrical property is positive power and the second electrical property is negative electrical power. 11. The dental health care product of claim 9, wherein the first electrical property is a negative electrical power and the second electrical electrical property is a positive electrical energy. 12. The dental health care product of claim 9, wherein the first diionic block and the second diionic block are polymerized using a double ionic monomer, the diionic monomer Is selected from one of the following groups: sulfur 100101362 Form No. A0101 Page 22 / Total 35 pages 1002002410-0 201221153 Sub-beet test (sufobetaine), carboxyl beet test (carboxylbetaine), derivatives of the aforementioned two monomers, the foregoing Any combination of the three. 13. The dental health care product of claim 9, wherein the first diionic block and the second diionic block are polymerized using a double ionic unit, and the diionic unit comprises A mixed charge monomer that contains two compounds of opposite electrical properties, but is generally neutral. 14. The dental health care product of claim 9, wherein the first antimicrobial copolymer and the second antimicrobial copolymer have a weight average molecular weight of equal to or greater than k 15 kDa. The dental health care product of claim 9, wherein the first diionic block and the second diionic block have a weight average molecular weight of equal to or greater than 10 kDa. 16. The dental health care product of claim 9, wherein the dental care product comprises a dentifrice, a toothpaste, a mouthwash, a tooth pre-wash, and a denture cleaner. 1002002410-0 100101362 Form No. A0101 Page 23 of 35