TW201208643A - Apparatus, system and method for detection and delivery of a medicinal dose - Google Patents
Apparatus, system and method for detection and delivery of a medicinal dose Download PDFInfo
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- TW201208643A TW201208643A TW100112416A TW100112416A TW201208643A TW 201208643 A TW201208643 A TW 201208643A TW 100112416 A TW100112416 A TW 100112416A TW 100112416 A TW100112416 A TW 100112416A TW 201208643 A TW201208643 A TW 201208643A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4833—Assessment of subject's compliance to treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/02—Pill counting devices
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- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
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- A61M15/00—Inhalators
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- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
- A61B2562/0214—Capacitive electrodes
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- A61M15/00—Inhalators
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0024—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with an on-off output signal, e.g. from a switch
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
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- A—HUMAN NECESSITIES
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/13—General characteristics of the apparatus with means for the detection of operative contact with patient, e.g. lip sensor
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- A—HUMAN NECESSITIES
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
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- A—HUMAN NECESSITIES
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61M2205/00—General characteristics of the apparatus
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- A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
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- A61M2205/00—General characteristics of the apparatus
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- A61M2205/3546—Range
- A61M2205/3569—Range sublocal, e.g. between console and disposable
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- A—HUMAN NECESSITIES
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
- A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
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- A—HUMAN NECESSITIES
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- A61M2205/00—General characteristics of the apparatus
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- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
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- A61M2205/00—General characteristics of the apparatus
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- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6009—General characteristics of the apparatus with identification means for matching patient with his treatment, e.g. to improve transfusion security
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Abstract
Description
201208643 · 六、發明說明: 【發明所屬之技術領域] 相關申請案之交又參考 本申請案係主張於2〇1〇年4月11日提出申請,標題 為“用於可吸入劑量之輸送的系統及方法(System and201208643 · VI. Description of the invention: [Technical field to which the invention pertains] Related application and reference to the present application claims to be filed on April 11, 2001, entitled "Used for the delivery of inhalable doses" System and method (System and
Method for Delivery 〇f an inhaiable Dose)’’的美國臨時專利 申請案第61/322,893號;於2010年6月22曰提出申請, 標通為用於彳貞測可吸入劑量之輸送之偵測的系統及方法 (System and Method for Detection of Delivery of an Inhalable Dose)”的美國臨時專利申請案第61/357,506號;以及於2〇1〇 年8月13日&出申請,標題為“用於伯測可吸入劑量之輸 送之偵測的系統及方法(System and Method for Delivery and Detection of an Inhalable Dose)’’的美國臨時專利申請案第 61/373,803號的權益,其中每一者於此係以全文引用方式併 入本案以為參考資料。 發明領域 本發明係有關於電子系統以及,更特定言之,係有關 於用於測定與確認醫藥劑量之輸送的電子系統。 【先前技術】 通常使用的醫藥輸送系統包括一腔室,用於儲存該劑 量。根據需要,病患使用該系統取用該醫藥劑量。然而, 並無精確的方式測定病患是否取用該劑量,或是病患何時 取用該劑量。例如,具有該等輸送系統其追蹤配藥或是輸 送的次數。然而,該等輸送系統無法測定是否以及何時將Method for Delivery 〇f an inhaiable Dose) ''US Provisional Patent Application No. 61/322,893; filed on June 22, 2010, for the detection of inhaled dose delivery U.S. Provisional Patent Application No. 61/357,506, to the System and Method for Detection of Delivery of an Inhalable Dose; and the application filed on August 13th, 2010, entitled "for U.S. Provisional Patent Application No. 61/373,803, the disclosure of which is incorporated herein by reference. This article is incorporated by reference in its entirety for reference. FIELD OF THE INVENTION The present invention relates to electronic systems and, more particularly, to electronic systems for determining and confirming delivery of medical doses. [Prior Art] A commonly used medical delivery system includes a chamber for storing the dose. The patient uses the system to take the medical dose as needed. However, there is no precise way to determine if a patient is taking this dose, or when the patient will take it. For example, having such delivery systems track the number of dispensings or deliveries. However, these delivery systems are unable to determine if and when
S 201208643 。例如,病患可在-短期間排放該輸送系 於送看見—段時間所取用的複數劍量。具有-些 :;〜、對輸送具有時間戳記,但無法測定病患實際上 、ί涵蓋劑量。例如,該病患可排放該輸送系 用以看’而未實際地Μ或是吸入該劑量’ 看見心-段較長期間規則地取用該劑量。因此,該 雨送系統無法測定該病患是否實際上接受該劑量。再 tii無精相方相定輯輸送的劑量是實際上如所音 =輪送至該病患。例如,賴送系統可已_病患以ΐ 专°此外’於一些例子中’該等輸送系統可能已 心外地^放。因此’所需者係為一系統及方法用以測定 =醫藥劑1係如所意欲地輸送至一病患以及追縱該輸送 二從容而】提刪地測定該病患實際上何時接受該劑量。 根據本發明之5亥等系統及指導的觀點,提供一系統及 方法’追織㈣量輸送至麵患的輸送時間,以及提供 確認該病患實際上接受該劑量。鮮、統包括叫貞測器及;; 裝置。該偵測器係在傳達上與該使用者結合並能夠侦測流 經該使用者㈣m該電流流動財該使用者與該 裝置接觸時產生。該裝置包括至少二接觸區域係與一電源 連接,以致當該使用者與該二接顧域之每—者接觸時完 成-電路’以及由此-電流路徑,並且由與該❹者結合 的一偵測器偵測到一電流流動。 於另一觀點中,該系統包括一偵測器以及一具有一聲 201208643 音單元的裝置。該偵測器在傳達上與該使用者結合並能夠 偵測流經該使用者身體的一電流流動,以及由該聲音單元 所產生的聲音資訊。該電流流動係在該使用者與該裝置接 觸時產生。該裝置包括至少二接觸區域係與一電源連接, 以致當該使用者與該二接觸區域之每一者接觸時完成一電 路,以及由此一電流路徑,並且由與該使用者結合的該偵 測器偵測到一電流流動。 【實施方式】 參考圖1A,顯示一使用者10配戴一偵測器20並與一 裝置3接觸;該偵測器20及該裝置3將於之後更為詳細地 加以說明。該偵測器20係顯示固定在該使用者身體的一位 置處並係與該使用者10作傳達上耦合,並能夠偵測通過該 使用者身體的一電流流動。然而,本發明之不同觀點的範 疇並不限定在將該偵測器20定位在該使用者身體上。該偵 測器20可經固定至該使用者身體上的任何位置。根據本發 明之另一觀點,該偵測器20係經固定至使用者的衣服。根 據本發明之另一觀點,該偵測器20可由使用者以珠寶、手 錶、服裝等形式加以配戴。於該等觀點中,該偵測器20可 在傳達上與該使用者結合,例如,與使用者接觸,最接近 使用者身體處,與使用者在傳達上最接近處等。 於目前所圖示的實例中,所顯示該偵測器20係為位在 該使用者體外的一偵測器。根據本發明之另一觀點,該偵 測器20可定位或是植入該使用者體内。於本發明之另一觀 點中,該偵測器20可部分地植入該使用者體内。該所研究S 201208643. For example, the patient may discharge the number of swords taken during the short period of time for the delivery to be seen. With - some :; ~, has a time stamp on the delivery, but can not determine the patient actually, ί covers the dose. For example, the patient may vent the delivery system to see 'and not actually lick or inhale the dose'. The dose is regularly taken during a longer period of the heart-segment. Therefore, the rain delivery system cannot determine whether the patient actually receives the dose. The dose delivered by the tii sessile phase is actually delivered to the patient as a sound. For example, the delivery system may have been afflicted with the patient. In addition, in some instances, such delivery systems may have been placed out of the way. Therefore, the 'required system is a system and method for determining = the pharmaceutical agent 1 is intended to be delivered to a patient and tracking the delivery, and the patient is actually receiving the dose. . According to the present invention, the system and method of providing a system and method for the delivery of the amount of delivery to the face, and providing confirmation that the patient actually receives the dose. Fresh, unified includes the detector and;; device. The detector is coupled to the user and is capable of detecting that the current flowing through the user (4) m is generated when the user contacts the device. The device includes at least two contact regions connected to a power source such that when the user is in contact with each of the two contact domains, the -circuit 'and the current path are completed, and the one is combined with the latter. The detector detects a current flow. In another aspect, the system includes a detector and a device having a sound of 201208643. The detector is communicatively coupled to the user and is capable of detecting a flow of current through the body of the user and sound information generated by the sound unit. This current flow is generated when the user is in contact with the device. The device includes at least two contact regions coupled to a power source such that when the user is in contact with each of the two contact regions, a circuit is completed, and thereby a current path, and the Detector is coupled to the user The detector detects a current flow. [Embodiment] Referring to Fig. 1A, a user 10 is shown wearing a detector 20 and in contact with a device 3; the detector 20 and the device 3 will be described in more detail later. The detector 20 is shown to be fixed to a location of the user's body and is communicatively coupled to the user 10 and is capable of detecting a current flow through the user's body. However, the scope of the different aspects of the present invention is not limited to positioning the detector 20 on the user's body. The detector 20 can be secured to any location on the user's body. According to another aspect of the invention, the detector 20 is secured to the user's clothing. According to another aspect of the present invention, the detector 20 can be worn by a user in the form of jewelry, watches, clothing, and the like. In such a view, the detector 20 can be communicatively coupled to the user, for example, in contact with the user, closest to the user's body, and closest to the user's communication. In the presently illustrated example, the detector 20 is shown as a detector external to the user. According to another aspect of the invention, the detector 20 can be positioned or implanted within the user. In another aspect of the invention, the detector 20 can be partially implanted within the user. Institute research
S 201208643 的體外牢固偵測器20包括該等係按適當尺寸製作而穩定地 以大體上不致與該生命體衝擊移動的一方式與一生命體結 合的該等者。就其本身而論,該偵測器20可具有的尺寸, 當固定至該使用者10時,將不致使該使用者10經歷在機 動性或是移動上的任何差異。 根據本發明之一些觀點,該偵測器20係按適當尺寸製 作以致其之尺寸不會妨礙該生命體身體上移動的能力。例 如,於一觀點中,該偵測器20具有一小尺寸,並且所佔用 的空間容積為5立方公分或較小,諸如3立方公分或較小, 包括1立方公分或較小。於另一觀點中,該偵測器20具有 一小尺寸,並且所佔用的空間容積為25立方公分或較小, 諸如12立方公分或較小,包括5立方公分或較小。於另一 觀點中,該偵測器20具有一小尺寸,並且所佔用的空間容 積為25立方公分或較小,諸如5立方公分或較小,包括1 立方公分或較小。根據本發明之一觀點,於該裝置3中可 包括一接收器(未顯示)。於該等例子中,該接收器具有一晶 片尺寸限制,範圍自2平方公厘至2平方公分。 該使用者10將該裝置3握持在該使用者的手中,並將 該裝置3安置至該使用者之口,從而與該裝置3至少於二 位置接觸,如圖所示。在小孩的例子中,父母可握持該裝 置3。於不同的觀點中,假若該小孩與父母接觸,則如以下 所說明,經由該父母與小孩完成一電路。為了清楚地說明 該裝置之功能性及其中的該等組件,以方塊圖的形式顯示 該裝置3。然而,根據本發明之不同的觀點,該裝置3可以 201208643 構成為多種的形狀。 現參考圖IB、1C及id,拍祕丄 該裝置3可為多種的形狀 '"#明之不同的觀點, 具有-腔室的ΐ = 及/或早一劑量,每一種劑鼍 韦匕3数種 咳使用者10。圖W f 輸送持續一段時間至 者目1C顯示該裝置3為一單一劑量吸入器, 具有一腔室能夠包含一劑量。名 罝及入态 . 1Λ ^ 則里在该早一劑量經輸送至該偾 用者10後’將該腔室重新裝填。圖1D顯示 吸入器其能夠連續地提供輸送-劑量,或是在預定二 二使用與-電源結合的—電動化單元27輸送 明=T吸人劑加實織形狀係視為涵 明她嘴内。因此’根據本發明之不同的觀點,該裝置3可 為不同的形狀以及劑量輸送裝傷,如於圖1B、1(:及1D中 :不’,並且本發明之該範,並未限定在該實際的形狀或劑 量輸送型式或是裝置之劑量輸送計時。 a於不同的觀點中,該示範裝置3,可包括一聲音單元或 疋如圖所示根據本發明之不同觀點的聲音單元,例如,分 別地與圖3B及5B中所示有關的裝置3〇及裝、置25,並 如以下之更為詳細的說明。 現參考圖2A,該裝置3包括一外殼32、一電源%、 一控制單元36、接點區域38、40以及一記憶體單元42。 該外殼32界定一腔室44用於包含該可吸入劑量。該腔室 44亦可包括一腔室控制單元用於控制該劑量之配送。該腔 至44亦包括一開口,該可吸入劑量係經由該開口輸送至該The in vitro secure detector 20 of S 201208643 includes such elements that are suitably sized to be stably coupled to a living body in a manner that does not substantially impinge on the movement of the living body. As such, the detector 20 can have dimensions that, when secured to the user 10, will not cause the user 10 to experience any differences in mobility or movement. In accordance with some aspects of the present invention, the detector 20 is sized such that its dimensions do not interfere with the ability of the living body to move on the body. For example, in one aspect, the detector 20 has a small size and occupies a volume of 5 cubic centimeters or less, such as 3 cubic centimeters or less, including 1 cubic centimeter or less. In another aspect, the detector 20 has a small size and occupies a volume of 25 cubic centimeters or less, such as 12 cubic centimeters or less, including 5 cubic centimeters or less. In another aspect, the detector 20 has a small size and occupies a space of 25 cubic centimeters or less, such as 5 cubic centimeters or less, including 1 cubic centimeter or less. According to one aspect of the invention, a receiver (not shown) can be included in the apparatus 3. In these examples, the receiver has a wafer size limit ranging from 2 square centimeters to 2 square centimeters. The user 10 holds the device 3 in the user's hand and positions the device 3 to the user's mouth to contact the device 3 in at least two positions, as shown. In the case of a child, the parent can hold the device 3. In a different view, if the child is in contact with the parent, a circuit is completed via the parent and the child as explained below. To clearly illustrate the functionality of the device and the components therein, the device 3 is shown in block diagram form. However, according to a different point of view of the present invention, the device 3 can be constructed in a variety of shapes in 201208643. Referring now to Figures IB, 1C and id, the device 3 can be of a variety of shapes '"# different views, with - chamber ΐ = and / or early dose, each agent 鼍 匕 3 Several cough users 10. Figure Wf is delivered for a period of time until 1C shows that the device 3 is a single dose inhaler having a chamber capable of containing a dose. Name and entry. 1Λ ^ Then the chamber is refilled after the early dose is delivered to the user 10. Figure 1D shows that the inhaler can continuously deliver a delivery-dose, or in a predetermined two-use combination with a - power supply - the motorized unit 27 delivers a clear = T inhaler plus a woven shape that is considered to be within her mouth. Thus, according to a different point of view of the present invention, the device 3 can be loaded for different shapes and doses, as in Figures 1B, 1 (and 1D: no), and the invention is not limited thereto. The actual shape or dose delivery pattern or dose delivery timing of the device. a. From a different perspective, the exemplary device 3 may comprise a sound unit or a sound unit according to a different aspect of the present invention as shown, for example The device 3 and the device 25 shown in Figures 3B and 5B, respectively, are described in more detail below. Referring now to Figure 2A, the device 3 includes a housing 32, a power source, and a Control unit 36, contact areas 38, 40 and a memory unit 42. The housing 32 defines a chamber 44 for containing the inhalable dose. The chamber 44 can also include a chamber control unit for controlling the dose. Dispensing the chamber 44 further includes an opening through which the inhalable dose is delivered
S 8 201208643 病患,如以下相關於圖7A之說明。根據本發明之一觀點, 該外殼32包括至少二接點區域/點38、40係配置在該外殼 32上的不同位置處。藉由該裝置3之形狀及設計以及根據 本發明之不同的觀點確定該等接點38、40或區域之處所與 位置。針對該等接點區域38、40,可考量複數位置。 根據本發明之另一觀點,該等接點區域38、40可包括 考慮到生物認證資訊,諸如指紋資料之讀取及記錄的功能 性。此資訊可傳達至該裝置3並儲存於其中,供使用者之 身分確認所用。 該等接點區域38、40係相互電隔離並且至少部分地露 出或是可露出,使該使用者10與之接觸。於一觀點中,該 等接點區域38、40亦可以一薄介電材料塗覆,諸如塑膠, 並經由此介電材料使用電容耦合完成與該使用者的電位傳 遞(electrical communication)。電容耗合可在信號頻率大於 約20kHz下完成,並且於一些觀點中,在80kHz下係具良 好的信噪比(SNR,例如信號對環境噪音)。根據本發明之一 觀點,該等接點區域38、40係經定位以致一接點區域38, 例如,與使用者的手接觸,以及另一接點區域40,例如, 與使用者的口接觸。根據本發明之可任擇的觀點,可增加 附加的接點區域,用以考慮到與手或口的第二接觸以及使 用一不同的手容納,諸如同時一左手握抓或是一右手握 抓。再者,可包括位在外殼32上的附加接點區域,用以確 保該裝置3係經正確地握持。假若該等接點區域38、40係 由介電材料所覆蓋,則該裝置與該使用者之口接觸,而該 201208643 使用者可或無法看見該等電極。例如,該等電極能夠叙入 在該塑膠材料中,並使用電容耦合感應該口之存在,並在 該口接觸该等平板之二者時尋找該二電容平板之間阻抗方 面之一大的變化。應察知的是該等接點區域38、4〇可配置 在接近或是該外殼32之該外部分上。於一觀點中,該等接 點區域38、40可為“部分地露出,,,以及於另一觀點中可 為“嵌入”在該外殼32中。於其他觀點中,該使用者可使用 非接觸方法與該等接點區域38、4G結合,諸如當該使用者 接近該等接點區域38、40時’偵測電場變化。 該電源34係電連接至該控制單元%並與該等接點區 域38、4G搞合。該電源34之—終端係電連接至 域40。該電源34之另一終端係電連接至該控制單元%。 如,所示,該電源34具有二輸出;—輸出係電連接至該控 制單元36以及該另-輸出係連接至該接點區域%。於 例中,該控制單元36係與該電源34串聯連接。然而, 發明之射並未限定在該控鮮元36係與該麵、34之 的相對電路關係。例如,該控制單元36可與該 : 聯配置’“致該控制單元36係、與該等接點區域3二仙以 及該電源34之二終端電連接。應察知的是,於某些觀點 該電源34產生交流電(AC)信號俾以不致使心臟顏動:假如 考量對於生命體之安全作業,可使用其他的信號。 當該裝置3與該使用者的手與口接觸時,該等接點區 域38、40與該使用者10接觸,產生包括該使用者⑺的二 兀整電路。因此,界定該電流路徑的該電路包括該使用者 201208643 Η)、該接點區域40、該電源34、該控制單元 點區域38。該電流路徑—經完成,該電源㈣供致使= 流動通過制者身體所需的電壓。因為魏置3現位於= 使用者之手中亚已與該使用者之口接觸,所以 的出現係為該$置3係位在用於配送該可吸人劑量二^ 位置的-指標。該制胃2〇識別電流流動通過使用 之存在,並能夠記錄該事件之發生的時序,如以下更為 細地加以說明。此外,該裝置3亦能_測該電流流動的 存在並記錄發线事件㈣間。因此,—旦完成該電路並 且偵測該電流流動,則該控制單元36亦能夠記錄該記憶體 單元42中該完成電路之該時序。 " 根據本發明之另-觀點,該控制單元36提供附加的控 制功能性。根據一觀點,該控制單元36能夠控制該電路之 電導性,其係通過s亥使用者身體而完成,用以將該電流流 動中資訊編碼。此外,該控制單元可將儲存在記憶體中也 同樣儲存在該流流動中的資訊疊置。例如,該電路之完成 的時序’與劑量有關的資訊,或是附加的識別資訊可於該 電流流動中加以編碼。該控制單元36改變該電路之電導 性。該改變的電導性導致該電流流動之特性的改變。該等 改變的特性在於包含該資訊,並因而將該資訊編碼於該電 流流動中,如於2009年9月21曰提出申請的美國專利申 請案第12/564,017號標題為具有部分電源的傳遞系統 (COMMUNICATION SYSTEM WITH PARTIAL POWER SOURCE),並公開為US 2010/0081894中所揭示者,該整 201208643 個說明書於此係併入本案以為參考資料。該經編碼資訊因 而藉由偵測器20偵測並解碼。此外,在2006年4月28日 k出申請的美國專利申請案第11/912,475號標題為製藥資 訊學系統(PHARMA-INFORMATICS SYSTEM)中揭示資 訊,並公開為US 2008/0284599其之整個說明書係併入本案 以為參考資料。 ’' 此外,根據本發明之另一觀點,該控制單元36可進入 一睡眠狀態用以將耗電量降到最小。該控制單元可藉由包 括電力、熱量、壓力、聲音等之一或更多已知方法^回至 一主動狀態。假使當使用聲音時,藉由裝載進入該腔室44 之該劑量所產生的聲音振動,可用以產生一啟動信號,其 係由一聲音單元,例如,輸送至該控制單元36。該啟動信 號可用以將該控制單元36由該睡眠狀態設定在一主動狀 態。一經啟動,該控制單元36能夠記錄附加的聲音資訊, 特別是與該使用者10經由該裝置3吸入有關的資訊。 現參考圖2B,根據本發明之另一觀點,該控制單元36 亦能夠使用附加的或是可任擇的傳達頻道,諸如無線及光 學,控制傳達。該控制單元36係耦合至並與一收發器46 連,,於該裝置3之一可任擇觀點中包括該收發器。該收 發益46係經組構以傳送及/或自該裝置3接收信息。儘管就 自》玄傳送盗46的傳送而言說明該傳達,但根據本發明之另 観點,於該裝置3中可包括一接收器(未顯示)並電連接至 。亥控制單元36。再者,根據本發明之另一觀點,該傳送器 46可以一能夠處理資訊之傳送與接收的收發器單元取代。 12 201208643 因此,該控制單元36使用複數之通訊頻道與方法容許該裝 置3與該偵測器20通訊。於一觀點中,該收發器係經組構 以與-外部裝置通訊,諸如一行動電話或是個人電腦、,用 以顯示發生該吸入事件。可以無線通訊方式取代或是除了 產生一信號之外使用無線方式指示該使用者已吸入。 該裝置3能夠與其他不同的裝置通訊,諸如具有一内 裝或周邊監視器的-電腦(諸如在一床邊監視器或是 康貝成系統中所見者)’ 一個人數位助理(pDA),一智慧型 手機’-訊息裝置’-資料中心等。此外,該裝置3曰可細 構形為通訊上,例如藉由詢問,與一外部裝置輕合用^ 或接收資料至-外部位置。可使用任—合宜的資料傳 包括經由-身體介f(例如,使用電流流動通過該 奸始Γ)及經由^氣二者,諸如無線轉傳輸協定。 3本發明之另—觀點,該偵測器2()傳送識別碼或資 二^置3 °該識別碼或資訊啟動該裝置3用以輸送劑 二測器2〇能夠確認該劑量之輸送,並傳送確 5忍貝訊至該裝置3指示該劑量經輸送。 根據本發明之另—觀點,該偵測器 直接地且獨立地與一第二穿置诵%,裝置3 一者 一雷Η<« 〇 矛—忒置通吼,啫如—行動電話或是 晉接= <訊的魏係與該劑量之輸送有關。此第三F =謂調節該資料及資訊用以使輸送時間 :病 患身份以及其他有關的係數 ^里病 /或該裝置3接收。 /母者7自_測器20及 依然參考圖2Β,該控制單元36係經定位與該電源34 13 201208643 並聯,因為該控制單元36係連接至每一接點區域38、40。 然而,本發明之範疇並未限定通過使用者身體所完成的該 電路内該控制單元36與該電源34的相對電路位置。例如, 該控制單元36能夠與該電源34串聯配置,以致該電源34 之一輸出係與圖2A中所示者相似地連接至該控制單元 36。如以上所說明,該控制單元36控制該電路之傳導特性 以及由此之該電流流動的特性。如此,該控制單元36能夠 將該電流流動中的貢訊編碼’並容許該電流特性搭載資訊 至該偵測器20。 現參考圖3A,顯示該使用者10配戴一偵測器20並與 一裝置30作身體的接觸。該裝置30係與之前說明的該裝 置3相似,並且於不同的觀點中,該裝置30包括一聲音單 元33,如圖3B-3D中所示。例如,於圖3B中,顯示該聲 音單元33係位在該氣流的路徑上,但非位在該醫藥的路徑 上。於圖3C中,顯示該聲音單元33係位在該氣流與醫藥 的路徑上。於圖3D中,顯示該聲音單元33係離開該氣流 與醫藥的路徑上。本發明之該範疇並未限定在該聲音單元 33與該氣流及醫藥的路徑相對的位置。以下將更為詳細地 說明該偵測器20與該裝置30之不同的觀點。 該使用者10將該裝置30握持在其之手中並將該裝置 30放置至該使用者之口,從而使與裝置30在至少二位置處 接觸,如圖所示。就幼童而言,父母可握持該裝置30。為 了清晰地說明其之功能性以及其中的該等組件,該裝置30 係以方塊圖顯示。然而,根據本發明之不同的觀點,該裝S 8 201208643 Patients, as described below in relation to Figure 7A. According to one aspect of the invention, the outer casing 32 includes at least two contact regions/points 38, 40 that are disposed at different locations on the outer casing 32. The location and location of the contacts 38, 40 or regions are determined by the shape and design of the device 3 and from the different perspectives of the present invention. For these contact regions 38, 40, a plurality of locations can be considered. According to another aspect of the present invention, the contact areas 38, 40 may include functionality that allows for biometric authentication information, such as reading and recording of fingerprint data. This information can be communicated to the device 3 and stored therein for confirmation by the user. The contact regions 38, 40 are electrically isolated from each other and at least partially exposed or exposed to bring the user 10 into contact therewith. In one aspect, the contact regions 38, 40 can also be coated with a thin dielectric material, such as plastic, and electrical communication with the user via the dielectric material using capacitive coupling. Capacitance fit can be done at signal frequencies greater than about 20 kHz, and in some respects, a good signal-to-noise ratio (SNR, such as signal-to-ambient noise) is achieved at 80 kHz. According to one aspect of the invention, the contact regions 38, 40 are positioned such that a contact region 38, for example, is in contact with the user's hand, and another contact region 40, for example, in contact with the user's mouth . In accordance with an optional aspect of the present invention, additional contact areas can be added to allow for a second contact with the hand or mouth and for a different hand accommodation, such as a left hand grip or a right hand grip. . Further, an additional contact area on the outer casing 32 can be included to ensure that the device 3 is properly held. If the contact areas 38, 40 are covered by a dielectric material, the device is in contact with the user's mouth, and the 201208643 user may or may not be able to see the electrodes. For example, the electrodes can be incorporated into the plastic material and capacitively coupled to sense the presence of the port and look for a large change in impedance between the two capacitive plates when the port contacts both of the plates. . It should be appreciated that the contact regions 38, 4A can be disposed proximate to or on the outer portion of the outer casing 32. In one aspect, the contact regions 38, 40 can be "partially exposed," and in another perspective can be "embedded" in the outer casing 32. In other aspects, the user can use non- The contact method is combined with the contact regions 38, 4G, such as detecting a change in electric field when the user approaches the contact regions 38, 40. The power source 34 is electrically coupled to the control unit % and is connected thereto. The point areas 38, 4G are engaged. The terminal of the power source 34 is electrically connected to the domain 40. The other terminal of the power source 34 is electrically connected to the control unit %. As shown, the power source 34 has two outputs; The output is electrically connected to the control unit 36 and the further output is connected to the contact area %. In the example, the control unit 36 is connected in series with the power source 34. However, the invention is not limited to the control. The fresh element 36 is in a relative circuit relationship with the surface, 34. For example, the control unit 36 can be configured in conjunction with the "control unit 36", the contact area 3, and the power source 34. The two terminals are electrically connected. It should be appreciated that in some instances the power source 34 produces an alternating current (AC) signal so as not to cause the heart to move: other signals may be used if safe for life is considered. When the device 3 is in contact with the user's hand and mouth, the contact areas 38, 40 are in contact with the user 10, creating a two-turn circuit including the user (7). Accordingly, the circuit defining the current path includes the user 201208643 Η), the contact area 40, the power source 34, and the control unit point area 38. The current path - after completion, the power source (4) is used to cause the voltage required to flow through the body of the manufacturer. Since Wei set 3 is now in the user's hand, the sub-contact has been in contact with the user's mouth, so the appearance is that the $3 line is in the indicator for dispensing the absorbable dose. The stomach 2 identifies the presence of current flow through use and is capable of recording the timing of the occurrence of the event, as described in more detail below. In addition, the device 3 can also measure the presence of the current flow and record the event (4). Thus, once the circuit is completed and the current flow is detected, the control unit 36 is also capable of recording the timing of the completion circuit in the memory unit 42. " According to another aspect of the invention, the control unit 36 provides additional control functionality. According to one aspect, the control unit 36 is capable of controlling the electrical conductivity of the circuit, which is accomplished by the body of the user to encode the information in the current flow. In addition, the control unit can superimpose information stored in the memory and also stored in the flow of the stream. For example, the timing of the completion of the circuit' dose related information, or additional identification information, can be encoded in the current flow. The control unit 36 changes the electrical conductivity of the circuit. The altered conductivity results in a change in the characteristics of the current flow. The characteristics of the changes are the inclusion of the information and the encoding of the information in the current flow, as described in U.S. Patent Application Serial No. 12/564,017, filed on Sep. 21, 2009, which is incorporated herein by reference. (COMMUNICATION SYSTEM WITH PARTIAL POWER SOURCE), and is disclosed in US 2010/0081894, the entire disclosure of which is incorporated herein by reference. The encoded information is thus detected and decoded by the detector 20. In addition, U.S. Patent Application Serial No. 11/912,475, filed on Apr. 28, 2006, is hereby incorporated by reference in its entirety in its entirety in its entirety in Incorporating this case into a reference. Further, in accordance with another aspect of the present invention, the control unit 36 can enter a sleep state to minimize power consumption. The control unit can be returned to an active state by one or more known methods including power, heat, pressure, sound, and the like. In case the sound is used, the sound vibration generated by loading the dose entering the chamber 44 can be used to generate an activation signal which is sent to the control unit 36 by a sound unit, for example. The enable signal can be used to set the control unit 36 from the sleep state to an active state. Upon activation, the control unit 36 is capable of recording additional audio information, particularly information relating to inhalation by the user 10 via the device 3. Referring now to Figure 2B, in accordance with another aspect of the present invention, the control unit 36 is also capable of controlling communication using additional or optional communication channels, such as wireless and optical. The control unit 36 is coupled to and coupled to a transceiver 46, which may be included in an optional view of the device 3. The revenue benefit 46 is configured to transmit and/or receive information from the device 3. Although the communication is illustrated in terms of transmission of the teleporter 46, in accordance with another aspect of the invention, a receiver (not shown) may be included in the apparatus 3 and electrically coupled thereto. Hai control unit 36. Still further, in accordance with another aspect of the present invention, the transmitter 46 can be replaced by a transceiver unit capable of processing the transmission and reception of information. 12 201208643 Thus, the control unit 36 allows the device 3 to communicate with the detector 20 using a plurality of communication channels and methods. In one aspect, the transceiver is configured to communicate with an external device, such as a mobile phone or a personal computer, to indicate that the inhalation event has occurred. It can be replaced by wireless communication or wirelessly indicating that the user has inhaled in addition to generating a signal. The device 3 is capable of communicating with other different devices, such as a computer with a built-in or peripheral monitor (such as seen in a bedside monitor or a Kangbeicheng system) 'a number of assistants (pDA), one Smart phone '-message device' - data center, etc. In addition, the device 3 can be configured to communicate, for example by inquiring, by using an external device or by receiving data to an external location. Any suitable data may be used including via the body (e.g., using current to flow through the traitor) and via both, such as a wireless transfer protocol. According to another aspect of the present invention, the detector 2() transmits an identification code or a value of 3°. The identification code or information activates the device 3 for transporting the second detector 2 to confirm the delivery of the dose. And transmitting a message to the device 3 indicating that the dose is delivered. According to another aspect of the present invention, the detector is directly and independently connected to a second device, a device 3, a thunder, or a spear-like device, such as a mobile phone or Promotion = < News of the Wei system is related to the delivery of this dose. This third F = adjusts the information and information used to make the delivery time: the patient's identity and other relevant factors ^ or the device 3 receives. The mother unit 7 is self-testing device 20 and still referring to FIG. 2A, the control unit 36 is positioned in parallel with the power source 34 13 201208643 because the control unit 36 is connected to each of the contact regions 38, 40. However, the scope of the present invention does not limit the relative circuit position of the control unit 36 and the power source 34 within the circuit that is completed by the user's body. For example, the control unit 36 can be configured in series with the power source 34 such that an output of the power source 34 is coupled to the control unit 36 similarly to that shown in Figure 2A. As explained above, the control unit 36 controls the conduction characteristics of the circuit and hence the characteristics of the current flow. Thus, the control unit 36 can encode the tribute in the current flow and allow the current characteristic to carry information to the detector 20. Referring now to Figure 3A, the user 10 is shown wearing a detector 20 for physical contact with a device 30. The device 30 is similar to the device 3 previously described, and in a different perspective, the device 30 includes a sound unit 33, as shown in Figures 3B-3D. For example, in Figure 3B, the sound unit 33 is shown to be in the path of the airflow, but not on the path of the medicine. In Figure 3C, the sound unit 33 is shown to be in the path of the airflow and medicine. In Figure 3D, the sound unit 33 is shown on the path separating the airflow from the medication. This category of the invention is not limited to the position of the sound unit 33 relative to the path of the airflow and medicine. The different views of the detector 20 from the device 30 will be described in more detail below. The user 10 holds the device 30 in its hand and places the device 30 to the user's mouth, thereby making contact with the device 30 at at least two positions, as shown. For young children, the parent can hold the device 30. In order to clearly illustrate its functionality and the components therein, the device 30 is shown in a block diagram. However, according to different views of the present invention, the package
S 14 201208643 置30能夠構成為複數之形狀。 現參考圖3E,时顯示該使用者1G經由接點區域AA 與-裝置3Ga接觸。圖中顯示該裝置施具有一電源通、 乂電,麵合益30c以及-接點區域3()d。該電容搞合器3〇c 係與《亥接點區域3〇d電隔離。該接點區域规係為一電極 或,板,代表與接地相對的—電容器的—側邊。圖中亦顯 不该使用者10配戴—偵測器2〇a其包括一電容耦合器 20c_。於圖3E中介於電容耦合器3〇c、2〇c之間係以一虛線 顯示-電容電導性路徑。於該圖式中,藉由線AA顯示該 使用者10與該裝置3〇a之間該身體接觸。顯而易見的是該 使用者10與該裝置3〇a之間該接觸實際上係為一身體接 觸,並能夠在該使用者10之口或手與該裝置3〇a之間發 生。本發明之該範疇並未限定在該裝置3〇a上與該使用者 10接觸的該區域。例如,使用者1〇與該接點區域30d接觸 的任何部分係涵蓋於本發明之範疇,如於2〇〇8年1月28 曰提出申請PCT專利申請案第pCT/2〇11/23〇17號,標題為 二腕式資料收集系統(TWO-WRIST DATA GATHERING SYSTEM) ’以及於2008年1月28曰提出申請PCT專利申 請案第PCT/2011/23013號,標題為手腕式資料收集系統 (WRIST DATA GATHERING SYSTEM),該每一者之整個 說明書於此併入本案以為參考資料。 現參考圖3E及圖3F,圖中以一分解視圖顯示位在該 使用者10之一皮膚位置20b處的該偵測器20a。該電容搞 合器20c包括一接點區域20d其係在皮膚位置20b處與該 15 201208643 使用者ίο接觸或是幾乎接觸,以及一非接觸側2〇e。經由 該使用者10之身體以及該接點區域30d,該電源3〇b係實 體上與該接點侧20d轉合。圖中所示該線路用以圖解根 據本發明之一觀點介於一貼片,經由該空氣及/或接地的一 電連接,該電容耦合器30c係與該偵測器20a之該電容性 糕合器20c麵合。在該裝置3〇a與該偵測器2〇a之間出現 電容耦合。因此,根據本發明之另一觀點,該裝置3〇a包 括一接點區域30d其係與該病患接觸,而—第二接點區域, 電谷搞合區域30c ’其係與該病患隔離。該裝置3〇a使用一 電容返回路徑經由空間與接地至該接受器。 因此,藉由使用該裝置30a之該控制模組,使用熟知 的技術將資訊加以編碼在該載波中而控制該電源3〇a之該 等隔離特性。例如,使用頻移鍵控(FSK)可將資訊編碼在該 載波中,包括二進位FSK。 / 現參考圖4A,該裝置3〇包括一外殼32、該聲音單元 33、-電源34、-控制單元36、接點區域38,4〇以及一記 憶體單it 42。斜殼32界定-腔室44用於容納該可吸入 劑量。該腔室44亦可包括一腔室控制單元用於控制該劑量 之配送。該腔室44亦可包括—開口,該可吸入劑量係經由 该開口輸运至該病患,以下相關於圖7A加以說明。根據本 發明m該接點區域/點38,4〇係配置在該外殼32上 的不同位置處。藉由該裝置3G切狀及設計以及根據本發 明之不_觀點確定料接點38、4q或區域之處所與位 置。針對該等接點ϋ域38、4G ’可考量複數位置。 201208643 該等接點區域38、40係相互電隔離並且至少部分地露 出,容許該使用者10與之接觸。根據本發明之一觀點,該 等接點區域38、40係經定位以致一接點區域38,例如,與 使用者的手接觸,以及另一接點區域40,例如,與使用者 的口接觸。根據本發明之可任擇的觀點,可增加附加的接 點區域,用以考慮到與手或口的第二接觸以及使用一不同 的手容納,諸如同時一左手握抓或是一右手握抓。再者, 可包括位在外殼32上的附加接點區域,用以確保該裝置30 係經正確地握持。 根據本發明之另一觀點,該等接點區域38、40包括考 量諸如指紋資料的生物認證資訊之讀取及記錄的功能性。 此資訊可傳達至該裝置30或是該聲音單元33並儲存於其 中用於確認該使用者的身份。 該電源34係電連接至該聲音單元33、該控制單元36 並與該等接點區域38、40耦合。該聲音單元33亦係電耦 合至該控制單元36,並相關於圖4C、4D及4E說明其之作 業。該電源34之一終端係電連接至該接點區域40。該電源 34之另一終端係電連接至該控制單元36。如圖所示,該電 源34具有二輸出;一輸出係電連接至該控制單元36以及 該另一輸出係連接至該接點區域38。於此實例中,該控制 單元36係與該電源34串聯連接。然而,本發明之範疇並 未限定在該控制單元36係與該電源34之間的相對電路關 係。例如,該控制單元36可與該電源34並聯配置,以致 該控制單元36係與該等接點區域38、40以及該電源34之 17 201208643 二終端電連接。 此外根據本發明之另—觀點,該控制單元%可進入 一睡眠狀態用以將耗電量降到最小。於該-情況下,任何 致使狀態改變的事件可使用作為—啟動信號,例如,將令 劑量裝載人該腔室44所產生聲音振動可心產生—啟^ 说,其係㈣聲音單元33輸送至該控制單元%。該啟動信 號可用以將4控制單凡36由該睡眠狀態設定在—主動狀 態° 了經啟動’該㈣單元36能夠記錄附加的聲音資訊, 特別$與該使用者1 〇經由該裝置3 Q吸人有關的資訊。 域38^=該使用者的手與口接觸時’該等接點區 — 者10接觸,產生包括該使用者10的一 電路因此’界定該電流路徑的該電路 10、該接點區域40、兮啻览乂從用有 ^ 電源34、該控制單元36以及該接 二、路彳^—經完成’該電源34提供致使電流 Γ田^ 者身體所需的電壓。因為該裝置30現位於該 的出規ίΠί已與該使用者之口接觸,所以該電流流動 '、’、、、°Λ、置3〇係位在用於配送該可吸入劑量的正確 位指標。該偵測器2〇識別電流流動通過使用者身體 之f在、’並能夠記錄該事件之發生的時序,如以下更為詳 户力t 乂說Θ此外’ S亥裝i 30亦能夠偵測該電流流動的 錄發生鱗相時間。因此,—旦完成該電路並 。…’貝ά電流流動,則該控制單元36亦能夠記錄該記憶體 早元42中該完成電路之該時序。 現參考® 4Β,根據本發明之另一觀點,該控制單元% 201208643 亦能夠使用附加的或是可任擇的傳達頻道,諸如無線及光 學,控制傳達。該控制單元36係耦合至並與一收發器46 連通,於該裝置30之一可任擇觀點中包括該收發器。該收 發器46係經組構以傳送及/或自該裝置30接收信息。儘管 就自該傳送器46的傳送而言說明該傳達,但根據本發明之 另一觀點,於該裝置30中可包括一接收器(未顯示)並電連 接至該控制單元36。再者,根據本發明之另一觀點,該傳 送器46可以一能夠處理資訊之傳送與接收的收發器單元取 代。因此,該控制單元36使用複數之通訊頻道與方法容許 該裝置30與該偵測器20通訊。於一觀點中,該收發器係 經組構以與一外部裝置通訊,諸如一行動電話或是個人電 腦,用以顯示發生該吸入事件。可以無線通訊方式取代或 是除了產生一信號之外使用無線方式指示該使用者已吸 入。 該裝置30能夠與其他不同的裝置通訊,諸如具有一内 裝或周邊監視器的一電腦(諸如在一床邊監視器或是一健 康資訊系統中所見者),一個人數位助理(PDA),一智慧型 手機,一訊息裝置,一資料中心等。此外,該裝置30可經 構形為通訊上,例如藉由詢問,與一外部裝置耦合用以提 供資料至一外部位置。可使用任一合宜的資料傳輸協定, 包括經由一身體介質(例如,使用電流流動通過該使用者身 體)及經由空氣二者,諸如無線資料傳輸協定。 根據本發明之另一觀點,該偵測器20傳送識別碼或資 訊至該裝置30。該識別碼或資訊啟動該裝置30用以輸送劑 19 201208643 量。此外,該偵測器20能夠確認 認資訊至歸置30’並傳送確 根據本發明之另一觀點,該偵測器2〇 者直接地且獨立地與一第三裝置〜" 一 J-電腦。該通訊的資訊係與該劑量之輪‘2動=或 =者將調節該資料及資訊用以-病患身份以及其他有關的係數, JJ〜釗里、 及/或該裝置30接收。 該母-者可自該偵測器20 依然參考圖犯,該控制單元36係 並聯,因為該控制單元36係連接至每、垃疋位』電源34 =’本發明之編未限二-者接=二 電路内該控制單元36與該電源 所-編 該控制單元36能夠與該電源34 /位置°例如’ 之-輸出係與® 4A中所示知/置,以致該電源34 36。如以上所說明,該控制單元3目6=^接至該控制單元 以及由此之該電流流動的特性。電路,傳導特性 將該電流路徑中的資訊編碼,並’ _制單元36能夠 至該偵測器20。 各。〇電流特性搭載資訊 現參考圖4C,於一觀點中,哼 一 鐵35及一線圈37。該線圈3 ^日早兀33包括一磁 接至圖4A之該控制單元分心3料 裝在-可移動或撓曲的表面上,1 认固疋至或是安 處。該㈣單元36測量當該_、37、^^近該磁鐵% 的磁場内移動或通過時所產生 在=磁鐵35相關聯 97屬机。隨者該線圈37 20 201208643 磁鐵35 _對位置改變’距離上的改變造成制 的變化。因此’由吸入或是將醫藥負 = 聲波’導致該磁鐵35之該磁場内該線圈37 的 該控制單元36經由該線圈37能夠偵測聲波。、 此 立,見參考圖4D ’根據本發明之另—觀點,圖中 曰單兀33包括一固定綠圈41以及—可 以聲 定線圈41係經由連接點41a與41b 源圈43接該固 :一線圈41的電力導致在該固定 磁场。該可移動線圈43係配置接近該 門圍的— ,連接點43a、43b連接至該控制單=圈二,由 %經由該可移動線圈43偵測與該固定 二拴制早元 趟場之存在。隨著該可移動線圈43與該固有關聯的該 财位置改變’在距離上的改變導致與該固定^、’=4^之相 的該電磁場之該特性的變化。當該使用者i q配=關聯 人或是經由該裝S 30吸入時,該等合成 =邊藥進 動線圈43之移動。因此,藉由吸入或是將華^成5亥可移 送所產生的聲波,導致該固定線圈q》電磁:载用以輪 圈-之移動36經由該可移動線 現參考圖4E,根據本發明之另—觀點,該 η =顯示包括一固定平板45及一可移動平板47。;亥= 5係經由連接點45a及45b連接至該電源34。供绔^ / —定平板45的電力造成該固定平板45周圍的 5亥 6亥可移動平板47係經定位在最接近該固定平板加。 21 201208643 由該等連接點47a、47b連接至該控 一 =由該可移動線圈43測量該固定平板45與=; 反47之_電容麵合。隨著該可移動平板π 板45之相對位置的改變距離上 固疋千 43與該可移動平板47之間 可移動線圈 改變。當該使用者H)將醫壯f有關聯之電容的特性 田雜用者10將j樂經由該裝置3〇配 吸入時,該合成聲波抵達該可移動平板们 或疋 二負載:醫藥用以輸送所產生的聲波,導多= 47之移動。因此,該控制單元 多動千板 侧聲波。 ^㈣可移動線圈43可 本發明的-優點在於該等聲音感應器能夠使 印刷電路板製造的製造技術,刻或是加色二自 _iti=printing)以低成本構成。藉由使用加色印片將妗二 該控制単7G的電路併人在該“電路,,板±,根據本發二 同觀點’可獲得進-步的優點。再者,根據本發明— 觀點’該電源可併入於該總成中。 根據本發明之不同的觀點,該聲音單元33,如以上 指出,可配置在該裝置30(圖3A)内的不同位置處諸如二 圖3D中所示自該氣流路徑與醫藥路徑離開處,如於圖0犯 中所示位在該氣流路徑内以及離開該醫藥路徑處,或B 於圖冗中所示位在該氣流路徑以及該醫藥路徑内處^ 外,根據本發明之另-觀點,該聲音單元33可定 置30的内部或是外部。 現參考® 5Α,顯示一使用者1〇配戴一谓測器2〇並與 Ο 22 201208643 一 ·#藥輸送裝置25作身體上接觸;以下將更為詳細地說明 該偵測器20及該裝置25。 該使用者10將難置25_在其之手中並將該裝置 30放置至該使用者之口,從而使與裝置25在至少二位置處 接觸,如圖所不。就幼童而言,父母可握持該裝置25。假 f小孩與父母接觸’則如以下所說明,經由該父母與小孩 =成▲電路。6亥裝置25界定一腔室用於包含該可吸入劑 董。該腔室亦可包括—腔室控制器單元,用於控制該劑量 之=送。該腔室亦包括—開σ,將該可吸人劑量經由該開 口輸送至該病患’如以下相關於圖从之說明。 一如旦乡考圖5B、5C及5D ’根據本發明之不同的觀點, 農置23係經固定至該裝置25,其能夠為複數之 ^οα _ Χ 5亥裴置之一觀點,該劑量確認裝置23包括一聲 卜例如’圖5Β顯示該劑量確認裝置23固定至該 m立以及該等接點區* 38、40。該劑量確認裝置η包 ==31。該裝置25係為具有一腔室的-直立式吸 二=夠接文―加壓罐其包含多重或是單—劑量,其中 顯示二:内個別地將每-劑量輸送至該使用者10。圖5C ’-劑i 為一單一劑量吸入11,具有一腔室能夠包含 腔室。 ^早—劑量輸送至該使用者1G後,再裝填該 單元之m該劑量確認裝置23及該聲音 如,灸考圉、、立的單元’能夠個別地固定至該裂置25。例 >考圖5D,該劑量確認裝置23及該聲音單元係為 23 201208643 蜀,f並f"分別地固定至該裝置25。該劑量確認裝置23 及°亥聲日單元31係相互連通並連接至鮮接點區域38、 4〇 °亥^置25係為—吸入器其能夠提使用接通一電源的一 電動化單元27供連續地輸送__劑量,或是在—預^的間隔 下輸送一劑置。根據本發明之該等觀點所揭示的該電源可 為一交流(AC)電源或是一直流(DC)電源。再者,該電源係 經设計用以確保該電流流動能夠在安全參數範圍内用於生 命體。 可考里用於輸送一可吸入劑量的附加實例及形狀,並 係涵蓋於本發明之範疇。因此,根據本發明之不同的觀點, 該裝置25可為不同的形狀以及劑量輸送裝備,如於圖5B、 5C及5D中所示,並且本發明之該範疇並未限定在該實際 的形狀或劑量輸送型式或是裝置之劑量輸送計時。 再者,本發明之範疇並未限定該裝置25中包括該聲音 單元31或是該聲音單元31係自該裝置25分離。更特定言 之’每一者具有特別的功能性及目的,並且就其本身而論 與另/者分開地作動以及相互合作。因此,任何裝置’包 括任何通常熟知的或是傳統的吸入器,能夠與該裝置25及 /或該聲音單元31任一者或是二者搭配使用,確認輸送一剑 量至〆使用者10,未對該裝置25作結構上的改變或修改。 根據本發明之一觀點,該聲音單元31包括一孔口富 該使用者10吸入時產生聲音。以與號笛相似的一方式’戎 聲音係由氣流通過該聲音單元31而產生。該聲音單兀31 係配f在該氣流的路徑上。當該使用者吸入時’該氣流S 14 201208643 The setting 30 can be configured in a plural shape. Referring now to Figure 3E, the user 1G is shown in contact with the device 3Ga via the contact area AA. The figure shows that the device has a power supply, a power supply, a face benefit 30c and a contact area 3 () d. The capacitor combiner 3〇c is electrically isolated from the "helium contact area 3〇d". The contact area is defined as an electrode or plate that represents the side of the capacitor opposite the ground. It is also shown that the user 10 is wearing - the detector 2A includes a capacitive coupler 20c_. In Figure 3E, a capacitance-conducting path is shown between the capacitive couplers 3〇c, 2〇c with a dashed line. In this figure, the physical contact between the user 10 and the device 3A is indicated by line AA. It will be apparent that the contact between the user 10 and the device 3A is in fact a physical contact and can occur between the mouth or hand of the user 10 and the device 3A. This category of the invention is not limited to the area of the device 3A that is in contact with the user 10. For example, any part of the user's contact with the contact area 30d is within the scope of the present invention, such as the application for PCT patent application pCT/2〇11/23 on January 28, 2008. No. 17, titled "TWO-WRIST DATA GATHERING SYSTEM" and the application for PCT Patent Application No. PCT/2011/23013 on January 28, 2008, titled Wrist Data Collection System ( WRIST DATA GATHERING SYSTEM), the entire specification of each of which is incorporated herein by reference. Referring now to Figures 3E and 3F, the detector 20a is shown in an exploded view at a skin location 20b of the user 10. The capacitive coupler 20c includes a contact area 20d that is in contact or nearly in contact with the user at the skin location 20b and a non-contact side 2〇e. The power source 3〇b is physically coupled to the contact side 20d via the body of the user 10 and the contact area 30d. The circuit shown in the figure is used to illustrate a patch according to one aspect of the present invention. The capacitive coupler 30c is coupled to the capacitive cake of the detector 20a via an electrical connection of the air and/or ground. The combiner 20c is joined. A capacitive coupling occurs between the device 3A and the detector 2A. Therefore, according to another aspect of the present invention, the device 3A includes a contact area 30d which is in contact with the patient, and a second contact area, the electric valley engaging area 30c' is associated with the patient isolation. The device 3A uses a capacitive return path via space and ground to the receptor. Thus, by using the control module of the device 30a, the information is encoded in the carrier using well known techniques to control the isolation characteristics of the power supply 3A. For example, frequency shift keying (FSK) can be used to encode information into the carrier, including the binary FSK. Referring now to Figure 4A, the apparatus 3A includes a housing 32, the sound unit 33, a power source 34, a control unit 36, contact areas 38, 4A, and a memory unit it 42. The angled housing 32 defines a chamber 44 for containing the inhalable dose. The chamber 44 can also include a chamber control unit for controlling the dispensing of the dose. The chamber 44 can also include an opening through which the inhalable dose is delivered to the patient, as described below with respect to Figure 7A. According to the invention m, the contact regions/points 38, 4 are arranged at different locations on the outer casing 32. The location and location of the material contacts 38, 4q or regions are determined by the device 3G cut and design and in accordance with the present invention. A plurality of locations can be considered for the contact domains 38, 4G'. 201208643 The contact regions 38, 40 are electrically isolated from each other and at least partially exposed to allow the user 10 to be in contact therewith. According to one aspect of the invention, the contact regions 38, 40 are positioned such that a contact region 38, for example, is in contact with the user's hand, and another contact region 40, for example, in contact with the user's mouth . In accordance with an optional aspect of the present invention, additional contact areas can be added to allow for a second contact with the hand or mouth and for a different hand accommodation, such as a left hand grip or a right hand grip. . Further, an additional contact area on the outer casing 32 can be included to ensure that the device 30 is properly held. According to another aspect of the present invention, the contact areas 38, 40 include functionality for reading and recording biometric authentication information such as fingerprint data. This information can be communicated to the device 30 or the sound unit 33 and stored therein for confirming the identity of the user. The power source 34 is electrically coupled to the sound unit 33, the control unit 36, and coupled to the contact regions 38, 40. The sound unit 33 is also electrically coupled to the control unit 36 and its operation is illustrated in relation to Figures 4C, 4D and 4E. One of the terminals of the power source 34 is electrically connected to the contact area 40. The other terminal of the power source 34 is electrically connected to the control unit 36. As shown, the power source 34 has two outputs; an output system is electrically coupled to the control unit 36 and the other output system is coupled to the contact area 38. In this example, the control unit 36 is coupled in series with the power source 34. However, the scope of the present invention is not limited to the relative electrical relationship between the control unit 36 and the power source 34. For example, the control unit 36 can be configured in parallel with the power source 34 such that the control unit 36 is electrically coupled to the contact regions 38, 40 and the terminals of the power source 34 201208643. Further in accordance with another aspect of the present invention, the control unit % can enter a sleep state to minimize power consumption. In this case, any event that causes a change in state can be used as a start signal, for example, to cause the sound of the sound generated by the chamber 44 to be generated by the dose loader, which is transmitted to the sound unit 33. control unit%. The activation signal can be used to set the 4 control unit 36 from the sleep state to the active state. After the activation, the unit (36) can record additional sound information, in particular with the user 1 吸 via the device 3 Q Information about people. Domain 38^=when the user's hand is in contact with the mouth, the contact areas are in contact with each other, generating a circuit including the user 10, thus defining the circuit 10, the contact area 40, The power supply 34, the control unit 36, and the second and second terminals are used to provide the voltage required to cause the current to flow to the body. Since the device 30 is now in contact with the user's mouth, the current flows ', ', ,, °, and 3 〇 in the correct position indicator for dispensing the inhalable dose. . The detector 2 identifies the current flowing through the user's body, and is able to record the timing of the occurrence of the event, as described in more detail below. The current flow is recorded in the scale phase. So, once the circuit is completed and . The control unit 36 is also capable of recording the timing of the completion circuit in the memory element 42. Referring now to Figure 4, in accordance with another aspect of the present invention, the control unit % 201208643 can also use an additional or optional communication channel, such as wireless and optical, to control communication. The control unit 36 is coupled to and in communication with a transceiver 46, which may be included in an optional view of the device 30. The transceiver 46 is configured to transmit and/or receive information from the device 30. Although the communication is illustrated in terms of transmission from the transmitter 46, in accordance with another aspect of the present invention, a receiver (not shown) can be included in the device 30 and electrically coupled to the control unit 36. Still further, in accordance with another aspect of the present invention, the transmitter 46 can be replaced by a transceiver unit capable of processing the transmission and reception of information. Thus, the control unit 36 allows the device 30 to communicate with the detector 20 using a plurality of communication channels and methods. In one aspect, the transceiver is configured to communicate with an external device, such as a mobile phone or a personal computer, to indicate that the inhalation event has occurred. It can be replaced by wireless communication or wirelessly indicating that the user has ingested in addition to generating a signal. The device 30 is capable of communicating with other different devices, such as a computer having a built-in or peripheral monitor (such as seen in a bedside monitor or a health information system), a number of PDAs, Smart phone, a message device, a data center, etc. Additionally, the device 30 can be configured to communicate, for example by interrogation, with an external device for providing data to an external location. Any suitable data transfer protocol can be used, including via a body medium (e.g., using current flowing through the user's body) and via air, such as a wireless data transmission protocol. According to another aspect of the invention, the detector 20 transmits an identification code or information to the device 30. The identification code or information activates the device 30 for the delivery of the agent 19 201208643. In addition, the detector 20 can confirm the information to the placement 30' and transmit another point according to the present invention. The detector 2 is directly and independently associated with a third device. computer. The communication information and the dose wheel '2 move = or = will adjust the information and information used - patient identity and other relevant factors, JJ ~ 钊, and / or the device 30 received. The parent may still commit the reference from the detector 20, and the control unit 36 is connected in parallel because the control unit 36 is connected to each of the power supply 34 = 'the second edition of the invention. The control unit 36 and the power supply unit can be associated with the power supply 34/position, for example, the output system and the power supply 34 36. As explained above, the control unit 3 is connected to the control unit and thus the characteristics of the current flow. The circuit, the conduction characteristic, encodes the information in the current path, and the unit 36 can be coupled to the detector 20. each. 〇 Current Characteristics Mounting Information Referring now to Figure 4C, in one aspect, an iron 35 and a coil 37 are used. The coil 3 ^ 3 early includes a magnet to the control unit of Figure 4A. The center of gravity 3 is mounted on a movable or deflectable surface, and 1 is secured to or secured. The (four) unit 36 measures when the _, 37, ^^ is moved within the magnetic field of the magnet % or is generated by the = magnet 35 associated with the machine. The coil 37 20 201208643 magnet 35 _ the change in position 'change in distance' causes a change in the system. Therefore, the control unit 36 of the coil 37 in the magnetic field of the magnet 35 by the inhalation or the medical negative = acoustic wave can detect the sound wave via the coil 37. Referring to FIG. 4D 'in accordance with another aspect of the present invention, the cymbal cymbal 33 includes a fixed green ring 41 and - the acoustic coil 41 is coupled to the source ring 43 via the connection points 41a and 41b: The power of a coil 41 causes the fixed magnetic field. The movable coil 43 is disposed close to the door circumference, and the connection points 43a, 43b are connected to the control unit = circle 2, and the % is detected by the movable coil 43 and the presence of the fixed binary system . The change in the distance as the movable coil 43 is associated with the inherently associated position change causes a change in the characteristic of the electromagnetic field in the phase of the fixed ^, '=4^. When the user i = is associated with the person or is inhaled via the device S 30, the synthesis = the movement of the edge medicine feed coil 43. Therefore, by the inhalation or the sound wave generated by the transfer, the fixed coil q electromagnetic: the movement 36 carrying the rim via the movable line is now referred to FIG. 4E, according to the present invention Alternatively, the η = display includes a fixed plate 45 and a movable plate 47. ; Hai = 5 is connected to the power source 34 via connection points 45a and 45b. The power supply for the sputum ^ / - plate 45 causes the 5 hai 6 hai movable plate 47 around the fixed plate 45 to be positioned closest to the fixed plate. 21 201208643 is connected to the control by the connection points 47a, 47b. The fixed plate 45 is measured by the movable coil 43 and the capacitance of the reverse 47 is combined. As the relative position of the movable plate π plate 45 is changed, the movable coil is changed between the fixed plate 43 and the movable plate 47. When the user H) selects the characteristic of the capacitor associated with the patient, the synthetic sound wave arrives at the movable tablet or the second load: the medical use The sound waves generated by the conveyor are guided by more than 47 movements. Therefore, the control unit multi-moves the side acoustic waves. ^ (4) Removable Coil 43 The advantage of the present invention is that the acoustic sensors enable the manufacturing process of printed circuit board manufacturing, or coloring, to be constructed at a low cost. By using an additive print, the circuit of the control 7G can be obtained in the "circuit, board ± according to the present invention". Further, according to the present invention - viewpoint The power source can be incorporated into the assembly. According to a different aspect of the invention, the sound unit 33, as indicated above, can be configured at different locations within the device 30 (Fig. 3A), such as in Fig. 3D. Detach from the airflow path and the medical path, as shown in Figure 0, in the airflow path and away from the medical path, or B in the airflow path and in the medical path In addition, according to another aspect of the present invention, the sound unit 33 can be set to be internal or external to 30. Referring now to the ® 5Α, a user 1 is shown wearing a predator 2〇 and with a Ο 22 201208643 The # drug delivery device 25 is in physical contact; the detector 20 and the device 25 will be described in more detail below. The user 10 will be in a difficult position 25_ and placed the device 30 in the use The mouth of the person, so that the device 25 is in contact with at least two positions, as shown in the figure No. For young children, the parent can hold the device 25. The fake f child is in contact with the parent', as explained below, via the parent and child = ▲ circuit. The 6 hai device 25 defines a chamber for The chamber may further comprise a chamber controller unit for controlling the delivery of the dose. The chamber also includes an opening σ through which the inhalable dose is delivered to the chamber The patient's description is as follows in relation to the figure. As in the case of the maps 5B, 5C and 5D, according to different views of the present invention, the farm 23 is fixed to the device 25, which can be a plurality of ^οα In view of the fact that the dose confirming device 23 includes a sound, for example, 'Fig. 5' shows that the dose confirming device 23 is fixed to the m and the contact regions * 38, 40. The dose confirming device η Package == 31. The device 25 is a one-chambered-upright suction=sufficient text-pressure tank containing multiple or single-dose, wherein two are shown: each dose is delivered individually to The user 10. Figure 5C '-agent i is a single dose inhalation 11 having a chamber capable of containing After the dose is delivered to the user 1G, the dose confirming device 23 and the sound such as the moxibustion test unit can be individually fixed to the split 25. > Referring to Fig. 5D, the dose confirming device 23 and the sound unit are 23 201208643 蜀, f and f" respectively fixed to the device 25. The dose confirming device 23 and the 亥 声 单元 unit 31 are connected to each other and connected The fresh contact area 38, 4 〇 ° ^ ^ 25 is the inhaler, which can be used to turn on a power supply of a motorized unit 27 for continuous delivery of __ dose, or at - pre-interval Deliver a dose. The power source disclosed in accordance with the teachings of the present invention may be an alternating current (AC) power source or a direct current (DC) power source. Furthermore, the power supply is designed to ensure that this current flow can be used for the life body within the safety parameters. Additional examples and shapes for delivering an inhalable dose are contemplated and are within the scope of the present invention. Thus, in accordance with various aspects of the present invention, the device 25 can be of different shapes and dose delivery equipment, as shown in Figures 5B, 5C, and 5D, and the scope of the invention is not limited to the actual shape or The dose delivery mode or the dose delivery timing of the device. Furthermore, the scope of the present invention is not limited to the fact that the device 25 includes the sound unit 31 or the sound unit 31 is separated from the device 25. More specifically, each has a particular function and purpose, and acts on its own and works separately with each other. Accordingly, any device 'comprising any conventionally known or conventional inhaler can be used in conjunction with either or both of the device 25 and/or the sound unit 31 to confirm delivery of a sword to the user 10, No structural changes or modifications have been made to the device 25. According to one aspect of the present invention, the sound unit 31 includes an aperture for generating sound when the user 10 inhales. In a manner similar to the horn, the sound is generated by the airflow through the sound unit 31. The sound unit 31 is equipped with f on the path of the air flow. When the user inhales the airflow
S 24 201208643 通過該裝置25及該聲音單元以生― 現參考圖5E,根據本㈣之另—觀點,= ”所產生的聲音信號係為在感應偵測使用者ι〇 …生t虎。1音單元31包括具有-記憶體單元的一 處理早tg3la、一聲音產生單开1 早兀3〗b ' —振動偵測單元3Ic 以及電源311。當錢用者1〇經由該 動_單元31C _振動並在感應該偵測事二二生錄 =。將該信號輸送至該處理單元31a用以指示該使 已吸人。該處理單元31a對該聲音產生單元3ib發出信 =用以產生-聲音信號。再者,該振動伯測單元w亦能 ^貞測當該劑量負載進入—腔室時由該裝置所產生的振 動’如以下說明。與該劑量之負載與該使用者1〇吸入有關 聯的振動,分別地產生一唯一的振動特徵⑽邮如 signature) ’月匕夠獨立地或是共同地使用,用以確認該劑量 f送至該使用者1〇。再者,根據本發明之另一觀點,該聲 音單元31能夠經由一收發器與一外部裝置通訊,諸如一行 動電δ舌或是一個人電腦,如於此所說明,用以指示發生該 吸入事件。無線通訊可取代或是除了產生一信號外,諸如, 例如,該聲音信號,使用無線通訊,指示該使用者已吸入。 現參考圖5F,根據本發明之另一觀點,該聲音單元31 包括一電源31j以及一麥克風31d。該麥克風3Id偵測藉由 及入及/或將該劑量負載進入該裝置25之該腔室中用於輸 送所產生的聲音振動。因此,能夠獨立地偵測裝填意欲輸 送的劑量之事件,以及在輸送時吸入的實際事件。經偵測 25 201208643 ^音通過-放大器31e以及一遽波器31f,至一數位器或 =類比數位轉換器31g。該滤波器祀,根據本發明之一 係f一低通濾波器。該數位器叫提供一數位信號 微产t制裔3】卜4控制盗3]h可為—可程式化處理器或是 妓處理b,其中能夠將控制指令程式化及改寫程式。 圍該吸入事件所產生的聲音資訊之範 的聲音資訊具有熟知的特性。例“裝填t =產裝置吸入時,-特別的裝 時產生的聲音資^予猎由每一裝置當裝填該劑量 吸入時===,已知範圍,以及當該使用者10 態機可用以取代一微處理Q的特性,一狀態機或是一有限狀 該控制器31h係為二=能二因此’根據本發明之-觀點’ 該控制器Μ提 據波器如,至一聲:產I”虎:通過=大器灿以及一 信號。由該控制器31:輸送二產生-聲音 下類型之資料的任—或争夕I揚卓::31n的信號包括以 元31係為獨一無二的=·識別資訊其對於該聲音單 ^與褒填進入該ί置25的;===_或劑 及該使用者10嗯入沾吐产 、序有關聯的資訊;以 該聲音單元3l s、此貪訊接著使用該聲音信號由 二疋31傳輸至該偵測器20。 元1G的制器2G _由該聲音單 卓9彳5唬,如以下說明。以此方式,任一裝置,S 24 201208643 Through the device 25 and the sound unit, referring to FIG. 5E, according to the other point of view (4), the sound signal generated by the =" is detected in the sense of the user ι 〇 ... ... .... The sound unit 31 includes a processing early tg3la having a -memory unit, a sound generating single open 1 early 3'b'-vibration detecting unit 3Ic, and a power source 311. When the money user 1 is via the mobile unit 31C_ Vibrating and sensing the detection event. The signal is sent to the processing unit 31a to indicate that the user has been inhaled. The processing unit 31a sends a letter to the sound generating unit 3ib = for generating a sound Further, the vibration test unit w can also detect the vibration generated by the device when the dose load enters the chamber as described below. The load with the dose is inhaled by the user. The associated vibrations respectively produce a unique vibration characteristic (10), such as signature, 'monthly enough to use independently or collectively to confirm that the dose f is sent to the user. Further, according to the present invention Another point of view is that the sound unit 31 can be connected via one The transceiver communicates with an external device, such as a mobile phone δ tongue or a personal computer, as described herein, to indicate that the inhalation event occurs. Wireless communication may replace or in addition to generating a signal, such as, for example, the The sound signal, using wireless communication, indicates that the user has inhaled. Referring now to Figure 5F, in accordance with another aspect of the present invention, the sound unit 31 includes a power source 31j and a microphone 31d. The microphone 3Id is detected by / or loading the dose into the chamber of the device 25 for transporting the generated acoustic vibrations. Therefore, it is possible to independently detect the event of loading the dose intended to be delivered, as well as the actual event that is inhaled during delivery. Measure 25 201208643 ^ tone-amplifier 31e and a chopper 31f, to a digital or analog-to-digital converter 31g. The filter 祀, according to one of the inventions, is a low-pass filter. The digitizer is called Provide a digital signal micro-production t-generation 3] Bu 4 control thief 3] h can be - programmable processor or 妓 processing b, which can be programmed to program and rewrite the program. The sound information of the sound information generated by the inhalation event has well-known characteristics. For example, "filling t = when the device is inhaled, - the sound generated by the special device is hunted by each device when the dose is inhaled = ==, the known range, and when the user 10 state machine is available to replace the characteristics of a micro-processing Q, a state machine or a finite state controller 31h is two = can be two thus 'according to the invention - Viewpoint 'The controller Μ Μ 如 如 : : : : : : : : : : 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产夕 I Yang Zhuo:: The signal of 31n includes the unique feature of the Yuan 31 series. = Identification information for the sound of the single and the 褒 fill into the ί 25; ===_ or agent and the user 10 The information associated with the production and sequence is transmitted to the detector 20 by the sound unit 3l s, which is then transmitted by the second signal 31. The unit 1G of the 1G _ is made up of 9 彳 5 唬, as explained below. In this way, any device,
S 26 201208643 包括任何通$沾知或疋傳統的吸入器,能夠搭配該聲音單 元31使用,用以確認將一劑量輸送至該使用者1〇,而二對 用以輸送該劑量的該裝置造成結構上變化或修改。如以上 所指示,根據本發明之另一觀點,該聲音單元31可、妙由_ 收發器通訊,用以指示已發生該吸入事件。 根據本發明之另一觀點,該聲音單元3丨亦包括接點連 接部分3lp及31q。該等接點連接部分3lp及31(1係電耦人 至或是連接至接點區域38及40’以下係相關於圖’6a加二 說明。 藉由該控制器31h收集的資訊,諸如生理學的或是产 境的資訊’係儲存在該記憶體單元3lr中供之後查詢鱼= 集所用。 根據本發明之另一觀點,該聲音單元31包括一無線通 訊模組,諸如一藍芽(Bluetooth®)模組,使用極低的耗電$ 與一外部裝置連通。例如,該外部裝置可為任何商業上= 得的硬體/軟體裝置,諸如行動電話、電腦、網路路由器、 运距醫療基地’以及欲入技術諸如一單—晶片參置、收於 器以及一鑰鍊(key fob)。因此,本發明之範疇並未限定在^ 該聲音單元31溝通的該類型之裝置。同樣地,本發明之^ ’並未限定在與該裝置25溝通的該類型之裝置。再者,所 父換之資料包括韌體映像(fireware image)、所收集未經處理 的資料、產生的資訊、資料管理資訊以及組態資料。 現參考圖6A,該劑量綠認裝置23係以方塊圖形式顯 示’用以清晰地說明其之功能性以及其中該等組件。然而, 27 201208643 該劑量確認裝置23能夠根據特定的設計需要以及該裝置 25之形狀,構成為複數之形狀。該劑量確認裝置23包括一 電源34、一控制單元36、接點區域38、40及一記憶體單 元42。根據本發明之一觀點,外殼32包括至少二接點區域 /點38、40,配置在外殼32上的不同位置處。接點38、40 或區域之處所與位置係藉由該裝置25之該形狀及設計,並 根據本發明之不同的觀點加以確定。考量複數之供接點 38、40所用的處所。再者,該等接點區域38、40可為該裝 置25之一部分或該劑量確認裝置23之一部分,或是該聲 音單元31的一部分。根據本發明之另一觀點,該等接點區 域38、40可分開地且獨立地附裝至該裝置25,容許客製化 該等接點區域38、40相對於該裝置25上該劑量確認裝置 23或是該聲音單元31的位置。 根據本發明之另一觀點,該等接點區域38、40可包括 容許讀取及記錄生物認證資訊,諸如指紋資料,的功能性。 此資訊可連通至該劑量確認裝置23或是該聲音單元31,並 儲存於其中用以確認該使用者的身份。 當該裝置25與該使用者之手及口接觸時,該等接點區 域38、40與使用者接觸造成包括該使用者10的一完整電 路。因此,界定該電流路徑的該電路包括該使用者、該等 接點區域40、該電源34、該控制單元36以及該接點區域 38。一旦完成該電流路徑,該電源34提供致使一電流流動 通過該使用者之身體所需的電壓。該電流流動的存在係為 一指示器,指示該裝置25係位在正確位置用於配送該可吸S 26 201208643 includes any conventional inhaler that can be used with the sound unit 31 to confirm delivery of a dose to the user, and two pairs of devices for delivering the dose Structural changes or modifications. As indicated above, in accordance with another aspect of the present invention, the sound unit 31 can communicate with the transceiver to indicate that the inhalation event has occurred. According to another aspect of the present invention, the sound unit 3A also includes contact connecting portions 3lp and 31q. The contact connecting portions 3lp and 31 (1 is electrically coupled or connected to the contact regions 38 and 40' are described below with reference to Figure 6a. The information collected by the controller 31h, such as physiological The learned or production information 'is stored in the memory unit 31r for later querying the fish=set. According to another aspect of the present invention, the sound unit 31 includes a wireless communication module, such as a Bluetooth ( The Bluetooth® module communicates with an external device using very low power consumption. For example, the external device can be any commercially available hardware/software device such as a mobile phone, computer, network router, and distance. The medical base 'and the desired technology such as a single-chip, a receiver, and a key fob. Therefore, the scope of the present invention is not limited to the type of device that the sound unit 31 communicates. The present invention is not limited to devices of this type that communicate with the device 25. Further, the parent exchanges information including the fireware image, the collected unprocessed data, and the generated information. Data management information Configuration Information Referring now to Figure 6A, the dose greening device 23 is shown in block diagram form to clearly illustrate its functionality and the components therein. However, 27 201208643 the dose confirmation device 23 can be based on a particular The design needs and the shape of the device 25 are formed in a plurality of shapes. The dose confirming device 23 includes a power source 34, a control unit 36, contact regions 38, 40, and a memory unit 42. According to one aspect of the present invention, The outer casing 32 includes at least two contact regions/points 38, 40 disposed at different locations on the outer casing 32. The locations and locations of the contacts 38, 40 or regions are by the shape and design of the device 25, and according to the present Different aspects of the invention are determined. The plurality of locations for the contacts 38, 40 are considered. Further, the contact regions 38, 40 may be part of the device 25 or part of the dose confirmation device 23, or A portion of the sound unit 31. According to another aspect of the present invention, the contact regions 38, 40 can be separately and independently attached to the device 25, allowing customization of the contact regions 38, 40. The dose confirmation device 23 or the location of the sound unit 31 is on the device 25. According to another aspect of the invention, the contact regions 38, 40 can include reading and recording biometric authentication information, such as fingerprint data, The information can be communicated to the dose confirmation device 23 or the sound unit 31 and stored therein for confirming the identity of the user. When the device 25 is in contact with the user's hand and mouth, Contacting the contact areas 38, 40 with the user results in a complete circuit including the user 10. Thus, the circuit defining the current path includes the user, the contact areas 40, the power source 34, and the control unit 36 and the contact area 38. Once the current path is completed, the power source 34 provides the voltage required to cause a current to flow through the body of the user. The presence of the current flow is an indicator that the device 25 is in the correct position for dispensing the smokable
S 28 201208643 入的劑量’由於該裝置25現係位在該使用者的手中並已與 該使用者之口接觸。該偵測器2〇識別通過該使用者身體的 電流流動之存在,並可記錄該事件之時序,以下將更為詳 細地說明。因此’一旦該電路完成並且偵測該電流流動, 則該控制單元36亦能夠記錄該記憶體單元42中該完成的 電路之時序。 再次參考圖5E及5f,根據本發明之不同的觀點,該 處理單元31a及該控制器31h可執行該控制單元36之功能。 根據本發明之另一觀點,該控制單元36提供附加的控 制功能性。根據一觀點,該控制單元36可控制該電路的之 傳導性’其係經由該使用者身體而完成,用以將該電流流 動中的資訊編碼。例如’可將該電路之完成的時序、與劑 量有關的資訊,或附加的識別資訊編碼於該電流流動中。 該控制單元36改變該電路之該傳導性。該改變的傳導性導 致該電流流動之該等特性的改變。該等改變的特性包含該 資訊,並因而將該資訊編碼於該電流流動中,如於2〇〇9年 9月21日提出申請的美國專利申請案第12/564,017號標題 為具有部分電源的通訊系統(COMMUNICATION SYSTEM WITH PARTIAL POWER SOURCE)中所揭示者,該完整的 說明書内容於此併入本案以為參考資料。該編碼的資訊接 著由該偵測器20所偵測並解碼。 附加地,根據本發明之另一觀點,該控制單元36可進 入一睡眠狀態用以將耗電量降至最低。於該一情況下,藉 由經裝填進入該腔室44的該劑量所產生的振動,可用以產 29 201208643 生一啟動信號,由該聲音單元31(圖5D)輸送至該控制單元 36。該啟動信號可用以將該控制單元36由該睡眠狀態置於 一主動狀悲。一經啟動,該控制單元36能夠記錄附加的 音資訊,特別是該使用者10經由該裝置25吸入有 資訊。 現參考圖6B,根據本發明之另一觀點,該控制單元妬 亦能夠使用附加的或是可任擇的通訊管道,諸如無線及光 學方式,控制通訊。該控制單元36係耦合至並盥二傳送器 46連通,於該劑量確認裝置23之一可任擇的觀點中包括节 傳送器。儘管所說明的該通訊係就源自於該傳送器牝_ 輸而言,但根據本發明之-觀點,可於該劑量確認裝置乃 中包括-接收H(未顯示)並電連接至該㈣單元% =虞ίΓί另一觀點,該傳送器46可以-收發器單 兀取代,其處理-貝訊之傳送與接收。因此,該控制單元 1該劑量確《置23使賴數_ 外部裝置通訊,諸如行=:3器係經組構以與-吸入事件。可以無線通人電腦’用以指示發生 信號外亦使隸線軌,指補使用除了產生一 該劑量確認裝置23能鈎血生从τ 1有一内與其不同的襄置通訊,諸如 具有内裴或周邊監現器的一電腦( 或是一健康資訊系統中所見者 纟邊I視益 -智慧型手機,-訊息裝置者)—f—二人數广理(腸), 劑量確認農置23可經構㈣由=中心專。此外,該該 机為由―外部裝置詢答用以提供資 30 201208643 料至一外部位置。可使用任一合宜的資料傳輸協定,包括 經由一身體介質(例如,使用電流流動通過該使用者身體) 及經由空氣二者,諸如無線資料傳輸協定。 再次參考圖6B,由於該控制單元36係該等接點區域 38、40之每一者連接,所以該控制單元36係與該電源34 並聯地配置。然而,本發明之範疇並未限定在經由使用者 身體所完成的該電路内,該控制單元36與該電源34之相 對電路位置上。例如,該控制單元36可與該電源34串聯 配置,以致與於圖6A中所示者相似該電源34之一輸出係 連接至該控制單元36。如以上所述,該控制單元36控制該 電路之傳導特性以及由此的該電流流動之特性。如此,該 控制单元3 6能夠將該電流路徑中之資訊編碼’並容許該等 電流特性搭載資訊至該偵測器20。 再次參考圖5A,圖中顯示該偵測器20係於一位置處 固定至主體。該偵測器20之位置係由醫藥需求與系統加以 確定。根據本發明之不同觀點所使用的該偵測器20,係經 組構為與一身體位置(身體之内側,部分内側或是一表面上) 相結合,並用以偵測源自於一或更多裝置,諸如圖5A之裝 置25,的電流與電信號。將該偵測器20附裝至主體之衣 服,以電極引線/線固定至該主體之皮膚或是用別的方法與 該主體之皮膚接觸亦係涵蓋於本發明之範疇。 現參考圖7A,根據本發明之一觀點,圖中顯示該裝置 3、30、25(如以上相關於圖1A_6B的說明)具有一開口50 及一膜片52。所示之該膜片52具有六部分52a、52b、52c、 31 201208643 52d、52e及52f。該膜片52係經定位在該裝置3、30、25 與該開口 50之間。因此,當配送該劑量以及該使用者10(圖 ΙΑ、3A、5A)吸入時,該膜片52之該等部分52a-f於該開 口 50之該方向上撓曲並分開,用以容許該劑量由該腔室44 行進通過該開口 50至該使用者10。 現參考圖7B,根據本發明之一觀點,該裝置3、25、 30(如以上相關於圖1A-6B所說明)包括光束感應器54a及 54b配置在該膜片52與該開口 50之間。如圖所示,當該膜 片部分52a、52b及52c係經橈曲用以容許該劑量由該腔室 44經由該開口 50通至該使用者10(如箭頭之方向指示)(圖 ΙΑ、3A、5A)時,介於該等感應器54a與54b之間的光束 56係經中斷。該光束56之中斷或破壞係由該膜片之之該等 部分52a-f所造成。此事件係為由該使用者10吸入的劑量 以及該等感應器54a及54b輸送一信號至該裝置3、25、30 之該控制單元36的一指示。該控制單元36因而能夠將該 電流流動中該資訊編碼或是將此資訊傳輸至該偵測器20, 並從而確認該劑量輸送至該使用者10。 根據本發明之另一觀點,該腔室44亦可在該膜片52 之前包括一光學間隙58。於該光學間隙中,至少一光學感 應器60係經定位用以偵測源自於亦包括在該光學間隙中的 一光源62,諸如一發光二極體(LED)的光放射。當該劑量 係經釋放進入該腔室44之該光學間隙時,該光學感應器60 偵測由於劑量之存在所造成的光強度下降,其係為一粉末 狀不透明物質。該光學感應器60係電耦合至該控制單元S 28 201208643 The dose entered because the device 25 is now in the user's hand and has been in contact with the user's mouth. The detector 2 identifies the presence of current flow through the user's body and can record the timing of the event, as will be explained in more detail below. Thus, once the circuit is completed and the current is detected to flow, the control unit 36 is also capable of recording the timing of the completed circuit in the memory unit 42. Referring again to Figures 5E and 5f, the processing unit 31a and the controller 31h may perform the functions of the control unit 36 in accordance with various aspects of the present invention. According to another aspect of the invention, the control unit 36 provides additional control functionality. According to one aspect, the control unit 36 can control the conductivity of the circuit 'by the user's body to encode the information in the current flow. For example, the timing of completion of the circuit, information relating to the dose, or additional identification information may be encoded in the current flow. The control unit 36 changes the conductivity of the circuit. The altered conductivity results in a change in the characteristics of the current flow. The characteristics of the change include the information and thus the information is encoded in the current flow, as described in U.S. Patent Application Serial No. 12/564,017, filed on Sep. 21, 2009, which is incorporated herein by reference. The disclosure of the entire contents of this specification is incorporated herein by reference. The encoded information is then detected and decoded by the detector 20. Additionally, in accordance with another aspect of the present invention, the control unit 36 can enter a sleep state to minimize power consumption. In this case, the vibration generated by the dose loaded into the chamber 44 can be used to generate an activation signal from the sound unit 31 (Fig. 5D) to the control unit 36. The enable signal can be used to place the control unit 36 in an active state by the sleep state. Upon activation, the control unit 36 is capable of recording additional audio information, particularly by the user 10 inhaling information via the device 25. Referring now to Figure 6B, in accordance with another aspect of the present invention, the control unit can also control communication using additional or alternative communication conduits, such as wireless and optical. The control unit 36 is coupled to the second transmitter 46 for communication, and includes a node conveyor in an optional view of the dose confirmation device 23. Although the communication system illustrated is derived from the transmitter, in accordance with the present invention, the dose confirmation device can include - receive H (not shown) and electrically connect to the (4) Unit % = 虞ίΓί Another point of view is that the transmitter 46 can be replaced by a transceiver unit that handles the transmission and reception of the beacon. Therefore, the control unit 1 determines that the dose is set to "the number of _ external device communication, such as line =: 3 is organized to - inhalation event. The wireless communication computer can be used to indicate that the signal is generated and the line is also used. In addition to generating a dose confirmation device 23, the blood can be communicated from the τ 1 with a different communication device, such as having a guilt or A computer in the peripheral monitoring device (or a person in a health information system, I see the benefits - smart phone, - message device) - f - two people (intestines), the dose confirmation of the farm can be 23 Construction (four) by = center. In addition, the machine is used by an external device to provide an external location. Any suitable data transfer protocol can be used, including via a body medium (e.g., using current flowing through the user's body) and via air, such as a wireless data transmission protocol. Referring again to Figure 6B, since the control unit 36 is connected to each of the contact areas 38, 40, the control unit 36 is arranged in parallel with the power source 34. However, the scope of the present invention is not limited to the relative circuit position of the control unit 36 and the power source 34 within the circuit that is completed by the user's body. For example, the control unit 36 can be configured in series with the power source 34 such that an output of the power source 34 is connected to the control unit 36 similar to that shown in Figure 6A. As described above, the control unit 36 controls the conduction characteristics of the circuit and thus the characteristics of the current flow. Thus, the control unit 36 can encode the information in the current path and allow the current characteristics to carry information to the detector 20. Referring again to Figure 5A, the detector 20 is shown secured to the body at a location. The location of the detector 20 is determined by the medical requirements and system. The detector 20 used in accordance with various aspects of the present invention is configured to be combined with a body position (inside, inside, or on a surface of the body) for detecting one or more Current and electrical signals for multiple devices, such as device 25 of Figure 5A. Attachment of the detector 20 to the garment of the subject, attachment of the electrode lead/wire to the skin of the subject or otherwise contacting the skin of the subject is also within the scope of the present invention. Referring now to Figure 7A, in accordance with one aspect of the present invention, the apparatus 3, 30, 25 (as described above with respect to Figures 1A-6B) is shown with an opening 50 and a diaphragm 52. The diaphragm 52 is shown to have six sections 52a, 52b, 52c, 31 201208643 52d, 52e and 52f. The diaphragm 52 is positioned between the device 3, 30, 25 and the opening 50. Accordingly, when the dose is dispensed and the user 10 (Fig. 3A, 5A) is inhaled, the portions 52a-f of the diaphragm 52 are flexed and separated in the direction of the opening 50 to permit the The dose travels through the opening 44 through the chamber 44 to the user 10. Referring now to Figure 7B, in accordance with one aspect of the present invention, the apparatus 3, 25, 30 (as described above with respect to Figures 1A-6B) includes beam sensors 54a and 54b disposed between the diaphragm 52 and the opening 50. . As shown, the diaphragm portions 52a, 52b, and 52c are warped to allow the dose to pass from the chamber 44 to the user 10 via the opening 50 (as indicated by the direction of the arrow) (Fig. At 3A, 5A), the beam 56 between the inductors 54a and 54b is interrupted. The interruption or destruction of the beam 56 is caused by the portions 52a-f of the diaphragm. This event is an indication of the dose inhaled by the user 10 and the sensors 54a and 54b delivering a signal to the control unit 36 of the device 3, 25, 30. The control unit 36 is thus capable of encoding the information in the current flow or transmitting the information to the detector 20 and thereby confirming that the dose is delivered to the user 10. According to another aspect of the invention, the chamber 44 can also include an optical gap 58 before the diaphragm 52. In the optical gap, at least one optical sensor 60 is positioned to detect light emissions originating from a light source 62, such as a light emitting diode (LED), also included in the optical gap. When the dose is released into the optical gap of the chamber 44, the optical sensor 60 detects a decrease in light intensity due to the presence of a dose which is a powdery opaque substance. The optical sensor 60 is electrically coupled to the control unit
S 32 201208643 36。一旦偵測光強度的變化,該光學感應器60即對該控制 單元36發出信號,用以指示該劑量的存在。 現參考圖7C,根據本發明之一觀點,該裝置3、25、 30(如於以上相關於圖1A-6B所說明)包括阻抗測量單元58a 及58b其配置在該膜片52與該開口 50之間。於該閉合位 置,當與該等部分52a-f接觸時該膜片52具有一唯一的阻 抗,其係藉由該等阻抗測量單元58a及58b所測量。一旦 該等膜片部分52a-f係經固定且分開,該膜片之該阻抗特性 及改變。如圖所示,當該等膜片部分52a、52b及52c係經 固定用以容許該劑量由該腔室44經由該開口 50通過至該 使用者1〇(如箭頭之方向所示)(圖ΙΑ、3A、5A)時,該等膜 片部分52a、52b及52c之移動致使該膜片52之阻抗的變 化。此阻抗的變化由該等阻抗測量單元58a及58b所偵測, 並係與該裝置3、25、30之該控制單元36通訊或是對其發 出信號。該控制單元36因而能夠將該電流流動中的資訊編 碼或是將此資訊傳輸至該偵測器20,並從而確認該劑量輸 送至該使用者10。 根據本發明之另一觀點,該裝置20包括一電容式觸覺 感應器控制單元(未顯示)。一旦該裝置20與該使用者的手 與口接觸,則該控制單元36接收源自於該感應器控制單元 的一信號,並且該控制模組啟動一腔室控制單元。該腔室 控制單元開始配送該劑量。根據本發明之一觀點,該裝置 20持續配送該可吸入至該使用者10(圖ΙΑ、3A、5A),以 致該裝置20係配送一持續的劑量。根據本發明之另一觀 33 201208643 點,忒裝置20係配送一單一的劑量。一旦該感應器控制單 f偵測,不再與該使用者之口或手接觸,則該感應 器控制單元送出一停止或是第二信號至該控制單元。該 控制單元36依次地對該腔室控制單元發出信號用以配 送該劑量〇 在-該Γ11 2G包括—處理單元其係配置 分暴露該處二=°_合至並_至部 該處理單元7()㈣f 76係纏繞該外殼72並電柄合至 該偵測器20包括二雷極。&乜唬於目别的貫例中, 該偵測考而,根據本發明之另一觀點, 並未限i在盘可'括較少或較多的電極,並且本發明之範疇 該細2〇相關聯的電極之數目。因此,於 多電極(諸如二或更多電極觀點,_測器2G包括一或更 之電極)用於偵測由賊置電極及/或包括複數對S 32 201208643 36. Upon detecting a change in light intensity, the optical sensor 60 signals the control unit 36 to indicate the presence of the dose. Referring now to Figure 7C, in accordance with one aspect of the present invention, the apparatus 3, 25, 30 (as described above in relation to Figures 1A-6B) includes impedance measuring units 58a and 58b disposed in the diaphragm 52 and the opening 50. between. In the closed position, the diaphragm 52 has a unique impedance when contacted with the portions 52a-f, as measured by the impedance measuring units 58a and 58b. Once the diaphragm portions 52a-f are fixed and separated, the impedance characteristics and changes of the diaphragm. As shown, the diaphragm portions 52a, 52b, and 52c are secured to permit passage of the dose from the chamber 44 through the opening 50 to the user 1 (as indicated by the direction of the arrow) (Fig. When ΙΑ, 3A, 5A), the movement of the diaphragm portions 52a, 52b, and 52c causes a change in the impedance of the diaphragm 52. This change in impedance is detected by the impedance measuring units 58a and 58b and communicates with or signals the control unit 36 of the device 3, 25, 30. The control unit 36 is thus capable of encoding or transmitting this information to the detector 20 and thereby confirming that the dose is delivered to the user 10. According to another aspect of the invention, the apparatus 20 includes a capacitive haptic sensor control unit (not shown). Once the device 20 is in contact with the user's hand and mouth, the control unit 36 receives a signal originating from the sensor control unit and the control module activates a chamber control unit. The chamber control unit begins dispensing the dose. According to one aspect of the invention, the device 20 continues to dispense the inhalable to the user 10 (Fig. 3A, 5A) such that the device 20 delivers a continuous dose. According to another aspect of the invention 33 201208643, the device 20 delivers a single dose. Once the sensor controls the single f detection and no longer contacts the user's mouth or hand, the sensor control unit sends a stop or second signal to the control unit. The control unit 36 sequentially sends a signal to the chamber control unit for dispensing the dose 〇 - the Γ 11 2G includes - the processing unit, the system configuration portion is exposed thereto, the second unit is coupled to the processing unit 7 (4) The f 76 is wound around the outer casing 72 and electrically coupled to the detector 20 to include two lightning poles. In the case of the subject, the detection, according to another aspect of the present invention, does not limit i to include fewer or more electrodes in the disk, and the scope of the present invention is fine. 2〇 The number of associated electrodes. Thus, in a multi-electrode (such as two or more electrodes, the detector 2G includes one or more electrodes) for detecting electrodes and/or including complex pairs by a thief
之說明)行進通過該使用^ 5、3G(如以上相關於圖1A_7C 槿形Φ *沾使者身體的電流信號。於所關注的一 20 】t μ又距離谷许該等電極偵測-差動電壓(differential ::::^ 不= 由I5至2.5公分。該偵測器20可包括複數之 ^ = 件與處理協定。此外,該镇測器 Θ U ^ ^ ΐ 0I外部或為可移植的,如於2 〇 1 〇年2 月υ曰徒出甲a青的美國真条 啤寻利申請案第12/564,017號,標蹲 34 201208643 為身體結合式接收器及方法中所揭示者,並公開為 2010-0312188 A1,於此以全文引用方式併入本案以為參考 資料。 現參考圖9,該處理單元70包括一放大器80其偵測橫 越圖8之該等電極74的差動電壓。該偵測電壓,其代表該 電流特性,係經由導線82輸送至放大器80,該導線係經由 該放大器80電連接至該等電極74。該偵測的電流特性因而 置入該解調器84。同時顯示一記憶體單元85其耦合至該解 調器84,一時鐘86以及一收發器單元89。該記憶體單元 85能夠儲存資訊,包括與該劑量輸送至該使用者10有關聯 的資料,以及在輸送該劑量至該使用者10或是由該使用者 10吸入之後該使用者生理學上狀況的變化。該時鐘86提供 時序資訊並寫入至該記憶體單元85,為了讓記錄在該記憶 體單元85中的該等事件留下時間戳記。該收發器單元89 將資料由該記憶體單元85轉移至一外部資料處理器單元, 圖中未顯示。例如,該收發器單元89能夠由一外部裝置接 收資訊或是直接地經由網際網路通訊用以收集與環境參數 有關的貧訊’以及提供特定的資訊包括.與病患有關的生 理學參數;以心率、體溫、呼吸速率、以及身體活動之程 度、持續時間及時序上的變化;劑量輸送之時序;劑量輸 送之頻率;以及感應該劑量輸送後的生理學參數的變化指 示潛在事件(例如,偶發事件或發作)之偵測。因此,該偵測 器20能夠提供資訊,經由無線通訊,用以自動偵測在輸送 之前的不利事件以及輸送之後對醫藥的反應。再者,該偵The description passes through the use of ^ 5, 3G (such as the above related to the Figure 1A_7C 槿 Φ * dip the body current signal of the messenger. At the attention of a 20 t t μ and distance from the valley to the electrode detection - differential Voltage (differential ::::^ does not = from I5 to 2.5 cm. The detector 20 can include a complex number of parts and processing protocols. In addition, the detector Θ U ^ ^ ΐ 0I external or portable For example, in the February 2nd, February, the gangsters of the United States, the real-life beer-seeking application No. 12/564,017, the standard 34 201208643 is disclosed in the body-integrated receiver and method, and The disclosure of which is hereby incorporated by reference in its entirety herein in its entirety in its entirety in its entirety in its entirety in the the the the the the the the the the the the the The detected voltage, which represents the current characteristic, is delivered via line 82 to amplifier 80, which is electrically coupled to the electrodes 74 via the amplifier 80. The detected current characteristics are thus placed in the demodulator 84. Simultaneously displaying a memory unit 85 coupled to the demodulator 84, one The clock 86 and a transceiver unit 89. The memory unit 85 is capable of storing information including information associated with the dose delivered to the user 10, and delivering the dose to the user 10 or by the user 10 The physiological state of the user changes after inhalation. The clock 86 provides timing information and writes to the memory unit 85 in order to leave a time stamp for the events recorded in the memory unit 85. The transceiver Unit 89 transfers the data from the memory unit 85 to an external data processor unit, not shown. For example, the transceiver unit 89 can receive information from an external device or directly via internet communication for collection. The information related to environmental parameters and the provision of specific information include physiological parameters related to the patient; changes in heart rate, body temperature, respiratory rate, and physical activity, duration and timing; timing of dose delivery The frequency of dose delivery; and the change in physiological parameters that sense the delivery of the dose to indicate a potential event (eg, an incident or episode) The detection. Therefore, the detector 20 can provide information via wireless communications to automatically detect prior to delivery of adverse events and reactions to medicine after delivery. Furthermore, the investigation
S 35 201208643 測器20能夠使用環境參數,諸如空中漂浮的花粉數或是空 氣污染程度,用以對該使用者提供與針對可能發生的事件 之可能性有關的特定資訊。再者,該偵測器20能夠記錄並 提供與該使用者10有關聯的基準資料。例如,利用相對於 身體活動之程度的心率與呼吸之基準測量,假若有限的或 是並無身體活動即具有高的呼吸速率,則能夠偵測疾病開 始發作。 該處理單元70亦包括一電源87其與一微處理器88電 耦合。該微處理器88係與所有組件電耦合並協調該等不同 的功能區塊與電力管理之間的功能。根據本發明之另一觀 點,該處理單元70之該等組件,包括該微處理器88,皆可 連接至一匯流排,因而經由該匯流排彼此電互連並由該微 處理器控制。 根據本發明之其他觀點,該整個系統包括該偵測器20 及該裝置3、25、30(如以上相關於圖1A-7C所說明)連通並 分別記錄與該劑量輸送至該使用者相關聯的該事件之一部 分。例如,如圖9中所示,該處理單元70包括一模組90。 利用配置在該使用者身體之最接近肺臟位置上的該偵測器 20,能夠藉由該模組90偵測該吸入的動作,其中該模組90 係為一加速度計,並記錄該事件。 根據本發明之另一觀點,該偵測器20之該處理單元70 其中該模組90係為一聲音偵測器。該聲音偵測器90偵測 與該使用者10深呼吸有關聯的聲音。根據本發明之另一觀 點,該聲音偵測器90亦偵測由圖4C之該聲音單元33或是S 35 201208643 The detector 20 is capable of using environmental parameters, such as the number of pollen floating in the air or the degree of air pollution, to provide the user with specific information regarding the likelihood of an event that may occur. Furthermore, the detector 20 is capable of recording and providing reference data associated with the user 10. For example, using a reference to heart rate and breathing relative to the extent of physical activity, if there is limited or no physical activity, that is, a high breathing rate, it is possible to detect the onset of the disease. The processing unit 70 also includes a power source 87 that is electrically coupled to a microprocessor 88. The microprocessor 88 is electrically coupled to all components and coordinates the functions between the different functional blocks and power management. In accordance with another aspect of the present invention, the components of the processing unit 70, including the microprocessor 88, are connectable to a busbar and are thereby electrically interconnected to each other and controlled by the microprocessor. According to other aspects of the present invention, the entire system includes the detector 20 and the devices 3, 25, 30 (as described above in relation to Figures 1A-7C) communicating and separately recording associated dose delivery to the user. Part of the event. For example, as shown in FIG. 9, the processing unit 70 includes a module 90. The detector 20 can be used to detect the inhalation action by the detector 20 disposed closest to the lungs of the user's body. The module 90 is an accelerometer and records the event. According to another aspect of the present invention, the processing unit 70 of the detector 20 is configured as a sound detector. The sound detector 90 detects sound associated with the user 10's deep breathing. According to another aspect of the present invention, the sound detector 90 also detects the sound unit 33 of FIG. 4C or
S 36 201208643 圖5E之該聲音單元31所產生的音響或是聲音信號。假若 該偵測器20已偵測源自於該裝置3、25、30(如以上相關於 圖1A-7C所說明者以及之後相關於圖12A-15B所說明的 400、500、600、700)之電流流動的存在,並記錄與吸入相 關聯的聲音,及/或與裝填該劑量有關聯由圖4C之該聲音 單元33或是圖5E之該聲音單元31所產生的聲音,則該聲 音偵測器90將記錄該吸入事件作為該劑量輸送至該病患的 表示。 根據本發明之另一觀點,該處理單元70係與包括一光 學偵測器的該模組90耦合。該模組90之光學偵測器將定 位在該偵測器20内,以致該外殼之一部分將為透明的並考 慮到一光束抵達該光學偵測單元90。 根據本發明之另一觀點,該偵測器20之該處理器70 可包括該加速度計、該聲音偵測器以及該光學偵測器之任 一結合。 根據本發明之不同的觀點,本發明之該系統可包括一 單一偵測器或是複數偵測器。就包括一單一偵測器的系統 而言,該偵測器可包括三或更多個別的電極,並可經構形 為配置在該使用者的一腹部或是劍突區域中。如為需要, 該等系統之該偵測器可配置在任一便利的位置處,諸如軀 幹之正面,軀幹之背面等。就具有複數偵測器的系統中, 每一接收器可具有一單一偵測器以及該等接收器可相互連 通,用以產生一偵測器之陣列。 根據本發明之另一觀點,該聲音偵測器及該電流流動 37 201208643 偵測可於該裝置3、25、30(如以上相關於圖1A-7C所說明) 中進行’並且該電流流動及該聲音振動二者的存在將指不 該裝置係藉由該使用者1〇(圖1A、3A、5A)維持在適當位 置,並且該劑量已裝填進入該腔室。 根據本發明之另一觀點,可使用一機械開關由一機械 動作產生一啟動信號,該開關係當該劑量裝填進入該腔室 或是經由該吸入器所需的一機械運動加以觸發,用以提供 該劑量輸送。 現參考圖10,該使用者10將該裝置3、25、30(如相 關於圖ΙΑ、3A、5A所說明者)配置至他或她的口並吸入。 根據本發明之另一觀點,該裝置3、25、30界定一孔口 310。 當該使用者10經由該裝置3、25、30之該口配件320吸入 時,經由該孔口 310的氣流產生一聲音,其係與由一哺子 所產生的聲音相似。由該裝置3、25、30所產生的該等聲 波行進通過周圍的空氣並進入該使用者10之肺臟。該等聲 波進入該使用者10之肺臟並行進通過該使用者的身體。該 偵測器20係經固定至該使用者10,並包括一聲音偵測器偵 測行進通過空氣以及通過該使用者10之身體的聲波。因 此,當該使用者10吸入時,由該裝置3、25、30之孔口 310 所產生的聲波可經偵測,並能夠與輸送劑量至該使用者10 有關的該事件相關聯。該聲波經由空氣與使用者之組織的 結合偵測係為確認該使用者10經由該裝置3、25、30吸入 並接收該劑量。再者,根據本發明之另一觀點,該裝置3、 25、30之該孔口 310可經調整用以產生一特別或是唯一的S 36 201208643 The acoustic or acoustic signal produced by the sound unit 31 of Fig. 5E. If the detector 20 has detected originating from the device 3, 25, 30 (as described above in relation to Figures 1A-7C and thereafter related to Figures 400A-B, 400, 500, 600, 700) The presence of a current flow, and recording the sound associated with the inhalation, and/or the sound produced by the sound unit 33 of FIG. 4C or the sound unit 31 of FIG. 5E associated with loading the dose, then the sound detection The detector 90 will record the inhalation event as a representation of the dose delivered to the patient. According to another aspect of the invention, the processing unit 70 is coupled to the module 90 including an optical detector. The optical detector of the module 90 will be positioned within the detector 20 such that a portion of the housing will be transparent and a light beam is received into the optical detection unit 90. According to another aspect of the present invention, the processor 70 of the detector 20 can include any combination of the accelerometer, the sound detector, and the optical detector. In accordance with various aspects of the present invention, the system of the present invention can include a single detector or a complex detector. In the case of a system including a single detector, the detector can include three or more individual electrodes and can be configured to be disposed in an abdomen or xiphoid region of the user. The detectors of such systems can be deployed at any convenient location, such as the front of the torso, the back of the torso, and the like, if desired. In systems with multiple detectors, each receiver can have a single detector and the receivers can be interconnected to produce an array of detectors. According to another aspect of the present invention, the sound detector and the current flow 37 201208643 can be detected in the device 3, 25, 30 (as described above in relation to Figures 1A-7C) and the current flows and The presence of both of the acoustic vibrations will mean that the device is maintained in position by the user 1 (Figs. 1A, 3A, 5A) and the dose has been filled into the chamber. According to another aspect of the present invention, a mechanical switch can be used to generate an activation signal from a mechanical action that is triggered when the dose is loaded into the chamber or via a mechanical motion required by the inhaler. This dose delivery is provided. Referring now to Figure 10, the user 10 configures the device 3, 25, 30 (as described with respect to Figures 3, 3A, 5A) to his or her mouth and inhales. According to another aspect of the invention, the device 3, 25, 30 defines an aperture 310. When the user 10 is inhaled through the mouthpiece 320 of the device 3, 25, 30, the airflow through the aperture 310 produces a sound similar to that produced by a female. The acoustic waves generated by the device 3, 25, 30 travel through the surrounding air and into the lungs of the user 10. The sound waves enter the lungs of the user 10 and travel through the body of the user. The detector 20 is secured to the user 10 and includes a sound detector that detects sound waves traveling through the air and through the body of the user 10. Thus, when the user 10 inhales, the sound waves generated by the orifices 310 of the devices 3, 25, 30 can be detected and associated with the event associated with delivering the dose to the user 10. The detection of the sound wave via the combination of air and tissue of the user confirms that the user 10 is inhaling and receiving the dose via the device 3, 25, 30. Furthermore, in accordance with another aspect of the present invention, the aperture 310 of the device 3, 25, 30 can be adjusted to produce a particular or unique
S 201208643 頻率,其進一步被使用作為確認該使用者10如預期地經由 該裝置3、25、30吸入。 根據本發明之另一觀點,一偵測器210可為配戴在該 使用者10之手腕上的一手錶之形式加以使用。 根據本發明之另一觀點,該偵測器可經移植並能夠與 位在該使用者身體外的一偵測器連通。如此,行進通過該 使用者身體的聲波可經偵測並與在該使用者身體外行進的 聲波相關聯。 現參考圖11,根據本發明之另一觀點,圖中顯示一出 入裝置100具有一針部分102以及一資料收集模組104。該 出入裝置100界定一出入口或開口 106。在醫院中或是在醫 院外居家照護的使用者或是病患極為常見地具有一出入裝 置100,諸如該出入裝置100,配置在該使用者方面持續期 間係自數小時至數日、數星期或甚至是數月。該出入裝置 100係用於複數種用途,包括將流體由身體引進及取出。該 出入裝置100能夠用以注射或注入醫藥與基本流體,以及 將諸如血液與排泄物之流體取出。一出入裝置100之典型 的實例包括:導管(靜脈的、泌尿的等等),IV出入口,人工 造管術口等。 就所有的該等裝置而言,具有因一般使用及清潔所造 成的高感染之影響度。正確地保養該出入裝置100包含在 使用之前正確地清潔及消毒該裝置口,特別是對於多於單 一使用仍維持在適當位置的該出入裝置100。就其之最為基 本的形式而言,清潔作業包含在將一注射器或是其他裝置 39 201208643 插入該出入口 夕义 入口⑽的動作二以一如同酒精的殺菌劑擦拭該出 務作法’包含正確的技術與每次作㈣花的良好貫 收集模組104係與該針部分 人♦ H貝枓 _合。可藉由該資料===之該邊 =該:用者身體上的—侧或與之連通 == 之該偵測器20。能夠使用所揭示的任一通m 協定將該資訊與該偵測器連通,包括㈣ 改變該載波。 现及疋 根據本發明之不同的觀點,可將該資料收集模組ι〇4 增加至該出人裝置UK)作為—附加裝置或是—重新設計的 出入口,追縱該口之保養。例如,能夠偵測與該出人口赐 之該邊緣接觸以及,因而清潔該出入口 106的花費時間, 包括記錄擦拭及將該出入口 106乾燥所花費時間總量。再 者’可記錄-注射器或是其他裝置插人該σ的時間以及該 注射器在該出入口 106中花費的總時間。該資料之收集可 用以顯示已正確地並係以正確的順序完成該出入口 1〇6之 保養,並且係在母次使用該口完成,如於揭示於在1 〇年 8月25曰出申δ青的美國臨時專利申請幸第61 /377 072 號’標題為用於病患出入口報告的系統與方法(SystemS 201208643 Frequency, which is further used to confirm that the user 10 is inhaled via the device 3, 25, 30 as intended. According to another aspect of the present invention, a detector 210 can be used in the form of a watch worn on the wrist of the user 10. According to another aspect of the present invention, the detector can be transplanted and can communicate with a detector located outside the body of the user. As such, sound waves traveling through the body of the user can be detected and correlated with sound waves traveling outside the body of the user. Referring now to Figure 11, in accordance with another aspect of the present invention, an access device 100 is shown having a needle portion 102 and a data collection module 104. The access device 100 defines an access or opening 106. A user or a patient who is in the hospital or outside the hospital is very often associated with an access device 100, such as the access device 100, which is configured for the duration of the user from hours to days, weeks Or even months. The access device 100 is used in a variety of applications, including the introduction and removal of fluids from the body. The access device 100 can be used to inject or inject medicine and essential fluids, as well as to remove fluids such as blood and feces. Typical examples of an access device 100 include: catheter (intravenous, urinary, etc.), IV access, artificial tube, and the like. For all of these devices, there is a high degree of infection due to general use and cleaning. Properly maintaining the access device 100 includes properly cleaning and disinfecting the device port prior to use, particularly for the access device 100 that remains in place for more than a single use. In its most basic form, the cleaning operation involves inserting a syringe or other device 39 201208643 into the entrance and exit (10) of the entrance and exit (10), wiping the service as an alcohol-based bactericide, including the correct technology. A good collection module 104 with each of the (four) flowers is combined with the needle portion. The detector 20 can be by the side of the data === = the side of the user's body or the sensor that is connected to ==. The information can be communicated to the detector using any of the disclosed m-comp., including (4) changing the carrier. According to a different point of view of the present invention, the data collection module ι 4 can be added to the exit device UK as an add-on or a redesigned entrance and exit to track the maintenance of the port. For example, it is possible to detect the time spent in contact with the edge of the population and thus the cleaning of the entrance 106, including the amount of time it takes to record the wipe and dry the outlet 106. Further, the time at which the sigma can be recorded by the syringe or other device and the total time the syringe spends in the port 106 can be recorded. The collection of this information can be used to show that the maintenance of the entrance and exit 1〇6 has been completed correctly and in the correct order, and is completed by the mother and child, as revealed in the publication of δ on August 25, 1st. C. US Provisional Patent Application No. 61 / 377 072 'System and Method for Patient Outlet Reports (System)
and method for patient ACCESS PORT REPORTING)中,其於此以全文引用方式併入本案以為參 考資料。 201208643 根據本發明之不同的觀點,該資料收集模組104使用 複數種方法感應該出入口 106之清潔或擦拭作業,包括阻 抗測量、聲音測量及壓力測量。例如,阻抗測量係藉由首 先測量配置在出入口 106的電極之間無傳導流體,諸如酒 精存在的阻抗而完成。當該出入口藉由酒精或是相似傳導 流體加以清潔時,該等電極間之阻抗係藉由該酒精或是消 毒擦拭物加以改變,並且可測量該阻抗的變化以及記錄該 變化之時序。當該酒精蒸發以及擦拭動作結束時,該阻抗 回復至先前的程度。 根據本發明之另一觀點,聲音偵測裝置可用以偵測與 該擦拭動作有關聯的信號或振動。此外,該資料收集模組 104能夠偵測在該出入口 106處該擦式動作有關聯的壓 力。將該出入裝置100與病患電連接,容許使用該電流信 號之改變而將資訊與該偵測器連通。根據本發明之不同的 觀點,用於在該資料收集模組104與由該使用者所佩戴的 該偵測器20之間通訊所用的該出入裝置100間之電連接, 係以複數之方法身體上或是機械地完成,包括傳導膠帶、 傳導性或是導体内嵌配管。 根據本發明之另一觀點,介於該使用者佩戴的該偵測 器20與該出入裝置100之該資料收集模組104之間的通訊 連接,可經由使用管壁或是使用該配管中流體作為該導体 的電容性傳導。 根據本發明之其他觀點,位在該出入裝置100上的感 應器可用以確認正確操作或保持該出入裝置100,並用以啟 41 201208643 動該資料收集模組104以文件證明該清潔作業以及該出入 裝置100之使用。例如,該裝置可經設計用以證實護士在 處理及出入該口時係使用手套。 根據本發明之另一觀點,亦可使用該資料收集模組 104,經由其與該使用者的接觸,用以測量局部的皮膚/身體 溫度並輸送一信號至該偵測器,警告感染。 該偵測器之可移植型式之觀點可具有一密封式且生物 學方面相容的腔室,其經界定用以作為封閉區域,例如, Chipskin™技術,一或更多感應電極,一電源,其可為一次 電池或是可再充電電池,或是藉由對一線圈感應地廣播而 提供電力者。就外部信號接收器而言,外觀包括具有與該 使用者皮膚接觸之電極的結構。該通訊可為無線式或是藉 由一或更多傳導性介質而執行,例如,電線、光纖等。於 需要處,可使用相同的電極用於接收及傳輸信號。 已說明用於輸送一可吸入劑量的醫藥輸送系統之不同 的觀點,現將轉向說明一般用於以複數之形式輸送醫藥產 品的醫藥輸送系統之不同的附加觀點。於不同的觀點中, 該等醫藥輸送系統可經設計並經構形用以輸送醫藥產品, 為一可消化產品的形式,諸如,例如一藥丸、一藥片、一 舌下錠、一聚合物分解錠、一膠囊、一乳膠體膠囊、一緩 釋口腔劑量、栓劑、一液體、一液體膠囊、一與一藥丸、 藥片(可溶解或是其他方式),或是膠囊結合的液體、一在其 他形式之醫藥之間包含藥丸、藥片(可溶解或是其他方式), 膠囊、液體、乳膠體的罩板包裝(blister pack)。於不同的觀And method for patient ACCESS PORT REPORTING), which is incorporated herein by reference in its entirety for reference. 201208643 In accordance with various aspects of the present invention, the data collection module 104 senses cleaning or wiping operations of the access 106 using a plurality of methods, including impedance measurements, sound measurements, and pressure measurements. For example, impedance measurements are accomplished by first measuring the impedance of the presence of no conductive fluid between the electrodes of the inlet and outlet 106, such as the presence of alcohol. When the inlet and outlet are cleaned by alcohol or a similarly conductive fluid, the impedance between the electrodes is changed by the alcohol or the disinfecting wipe, and the change in impedance and the timing of recording the change can be measured. When the alcohol evaporates and the wiping action ends, the impedance returns to the previous level. According to another aspect of the present invention, a sound detecting device can be used to detect a signal or vibration associated with the wiping action. In addition, the data collection module 104 is capable of detecting the pressure associated with the wipe action at the entrance 106. The access device 100 is electrically coupled to the patient to allow communication of the information with the detector using the change in the current signal. According to a different aspect of the present invention, the electrical connection between the access device 100 for communication between the data collection module 104 and the detector 20 worn by the user is in the form of a plurality of It is done mechanically, including conductive tape, conductive or in-line conductors. According to another aspect of the present invention, the communication connection between the detector 20 worn by the user and the data collection module 104 of the access device 100 can be via the use of a tube wall or the use of a fluid in the tube. As a capacitive conduction of the conductor. According to other aspects of the present invention, an inductor located on the access device 100 can be used to confirm proper operation or maintenance of the access device 100, and to activate the data collection module 104 to document the cleaning operation and the access. Use of device 100. For example, the device can be designed to verify that the nurse uses gloves when handling and accessing the mouth. According to another aspect of the present invention, the data collection module 104 can also be used to measure local skin/body temperature and provide a signal to the detector via its contact with the user to alert the infection. The view of the portable version of the detector can have a sealed and biologically compatible chamber defined as a closed region, such as ChipskinTM technology, one or more sensing electrodes, a power source, It can be a primary battery or a rechargeable battery, or can be powered by inductively broadcasting to a coil. In the case of an external signal receiver, the appearance includes a structure having electrodes in contact with the skin of the user. The communication can be performed wirelessly or by one or more conductive media, such as wires, fibers, and the like. The same electrodes can be used to receive and transmit signals where needed. Having described the different perspectives of a medical delivery system for delivering an inhalable dose, it will now turn to a different additional point of view for a medical delivery system that is generally used to deliver pharmaceutical products in the plural. In various aspects, the medical delivery systems can be designed and configured to deliver a medical product in the form of a digestible product, such as, for example, a pill, a tablet, a sublingual tablet, a polymer decomposition. Ingot, a capsule, a latex capsule, a sustained release oral dose, a suppository, a liquid, a liquid capsule, a pill, a pill (soluble or otherwise), or a capsule-bound liquid, one in the other Forms of medicine include pills, tablets (soluble or otherwise), capsules, liquids, and blister packs of latex. Different views
S 42 201208643 點中’該醫藥可包括可攝食裝置,諸如,例如,可攝食事 件標誌(IEMs),如於2009年9月21日提出申請的美國專 利申請案弟12/564,017號標題為具有部分電源的通訊系統 中所揭不者,並公開為US 2010/0081894,該整個說明奎於 此併入本案以為參考資料。於另一實例中,該醫藥可包括 可攝艮裝置其包含射頻識別(RFID)功能,例如,主動式rfid 裝置或是被動式RFID裝置。視該特定的構形而定,該醫藥 可經密封或開啟。然而,該揭示觀點之範疇並未由產品之 形狀或型式所限定。連同該等用語“攝食(ingested或ingest 或ingesting)’’的一可攝食產品係理解為意指任何的將產品 引進身體内並可包括口服的、肛門、陰道引進產品或是任 何的將產品引進一人體自然腔道(natural body orifice)。 現參考圖12A ’顯示該使用者10配戴一偵測器2〇以 及與一裝置400作身體上接觸。該裝置400係經組構以輸 送為藥丸、藥片或是膠囊(藥丸)之形式的醫藥。該偵測器 20係顯示固定在該使用者身體上的一位置處,並係通訊上 與該使用者1〇耦合,以及能夠偵測通過該使用者身體的電 流流動。然而’本發明之不同觀點的範疇並未限定在將該 侦測器20定位在該使用者的身體上。該偵測器2〇可經固 定至該使用者身體上的任何位置。根據本發明之另一觀 點’該偵測器20係經固定至使用者的衣服。根據本發明之 另一觀點’該偵測器20可由使用者以珠寶、手錶、服裳等 形式加以配戴。於該等觀點中,該偵測器20可在通訊上與 該使用者結合,例如,與使用者接觸,最接近使用者身體 43 201208643 處,與使用者在通訊上最接近處等。於一觀點中,該偵測 器20可配置在該使用者的身體上俾以偵測與該使用者10 吞藥丸劑量有關聯的肌肉移動。根據在不同的位置中以及 在該使用者身體上定向的電極或是接點區域之定位,考量 附加的吞嚥偵測技術。 如以上所說明,該偵測器20係為位在該使用者體外的 一偵測器。根據本發明之另一觀點,該偵測器20可定位或 是植入該使用者體内,特別是與和吞嚥動作有關聯之舌頭 移動有關。例如,在吞嚥動作期間,舌頭係朝向上顎向上 地移動。因此,該偵測器20或是與該偵測器連通的接點區 域可經定位用以偵測該移動,確認該吞嚥的動作。於本發 明之另一觀點中,該偵測器20可部分地植入該使用者體 内。該所研究的體外牢固偵測器20包括該等係按適當尺寸 製作而穩定地以大體上不致與該生命體衝擊移動的一方式 與一生命體結合的該等者。就其本身而論,該偵測器20可 具有的尺寸,當固定至該使用者10時,將不致使該使用者 10經歷在舒適性、機動性或是移動上的任何差異。 圖12B圖示該醫藥輸送裝置400之一觀點,用於將一 單個的藥丸由一藥丸貯存器輸送。該裝置400包含一外殼 402,其具有一腔室404(貯存器或是容器)部分用於儲存複 數之單個的藥丸406,以及一輸送管408或裝置用於輸送一 單個的藥丸劑量406a。該使用者10在其之手中握持該裝置 400並將該裝置400置於其之口,從而在至少二位置處與該 裝置400接觸。該使用者10接著啟動一藥丸輸送機構用以 201208643 將一處方的藥丸劑量406a輸送進入該輸送管408。儘管該 裝置400係顯示輸送一單一劑量4〇6a,但是該裝置可經設 計或構形用以根據一處方醫藥計晝輸送複數的藥丸劑量。 就幼童而言,父母可握持該裝置400。於不同的觀點中,假 若孩童與父母接觸,則如以下說明,經由父母與孩童完成 一電路。為了清楚地說明其之功能性以及其中組件,該裝 置400係以方塊圖形式顯示。然而,根據本發明之不同的 觀點’該裴置400能夠構成為複數的形狀。例如,於一觀 點中,該裝置400可經設計或構形用以在該使用者的直腸 中輸送一栓劑。因此,能夠以一方式配置該偵測器2〇用以 偵測實際的栓劑劑量之輸送。 圖12C圖示該醫藥輸送裝置400的一觀點,用於由一 藥丸貯存器輸送一單個的藥丸。於圖12C中所圖示的該裝 置400包含一外殼402,其具有一腔室404(貯存器或是容 器)部分用於儲存複數之單個的藥丸406,以及一輸送管408 或是裝置用於輸送一單個的藥丸劑量406a。該裝置400進 一步包含一致動器410在操作上與一藥丸閥416 口或是閂 鎖機構耦合,用於控制該單個的藥丸劑量406a經由該藥丸 閥416之輸送,其可為電力地、機械地或是機電地作動。 於不同的觀點中’該致動器410可包含與該口 416 —機械 式按钮、控制桿或是彈簣,以致由該使用者接觸致動器致 使閥416輸送該單一藥九劑量406a。於其他的觀點中,該 致動器可包含一機電式或電氣式按鈕或開關其係以電子方 式與該電動藥丸閥416耦合,致使與該致動器410接觸產 45 201208643 生電子式控㈣σ 416或閃鎖之位置,用以輸送該單一藥 丸劑量4嶋。可考量機械式、電氣式、電子式及/或機電式 致動機構?,他結*者以及其他口或㈣機構,用以精確 地控制輸送藥丸劑量,通常為—藥丸,但可經構形為亦能 夠控制輸送複數的藥丸劑量。 於圖UC中亦圖示至少二接點區域412及414其係經 由該使用者身體與該_器2G電輕合。該使用者1〇將該 裝置40"G握持於其之手中並將該裝置_放置至該使用者 ^口從而使该第—接點412與使用者之口接觸以及該第 接點4M與使用者之手接觸,藉此與該裝置棚於至少 -位置處接觸’如圖所示。該使用者1()接著啟動藥丸輸送 ^冓用以將-處方或是預定的藥丸劑量槪a輸送進入該輸 送管408。13此,如以上所說明,該至少二接點區域412、 414係連接至一電源以致當該使用者與二接點區域412 414 之每一者接觸時完成一電路以及因之的一電流路徑,並且 藉由與該使用者10耦合的偵測器2〇偵測一電流流動。 圖12D圖示該醫藥輸送裝置4〇〇之一觀點,用於由個 別密封藥丸之一貯存器輸送一單個的藥丸。於圖12D中圖 示的該裝置400包含一外殼402,其具有一腔室404(貯存 器或是容器)部分用於將複數之個別密封的藥丸406儲存在 一密封的包裝418(為了清晰性以虛線顯示)中,以及一輸送 管408或是裝置用於輸送一單個的藥丸劑量406a。該裝置 400進一步包含一電動式藥丸閥420,其當如相關於圖12C 說明藉由一致動器機構410(未顯示)啟動時,該電動式藥丸S 42 201208643 'The medicine may include ingestible devices such as, for example, ingestible event markers (IEMs), as disclosed in the U.S. Patent Application Serial No. 12/564,017 filed on Sep. 21, 2009. The communication system of the power supply is not disclosed and is disclosed in US 2010/0081894, the entire disclosure of which is incorporated herein by reference. In another example, the medicine can include a camera device that includes a radio frequency identification (RFID) function, such as an active rfid device or a passive RFID device. Depending on the particular configuration, the medicine can be sealed or opened. However, the scope of this disclosure is not limited by the shape or type of the product. An ingestible product, together with the phrase "ingested or ingest or ingesting", is understood to mean any introduction of the product into the body and may include oral, anal, vaginal introduction or any introduction of the product. A natural body orifice. Referring now to Figure 12A', the user 10 is shown wearing a detector 2 and physically contacting a device 400. The device 400 is configured to be delivered as a pill. Medicine in the form of a tablet or capsule (pill). The detector 20 is shown at a location on the body of the user and is communicatively coupled to the user and is capable of detecting The current flow of the user's body. However, the scope of the different aspects of the present invention is not limited to positioning the detector 20 on the user's body. The detector 2 can be fixed to the user's body. According to another aspect of the present invention, the detector 20 is fixed to the user's clothes. According to another aspect of the present invention, the detector 20 can be jeweled, watched, or worn by a user. In such a manner, the detector 20 can be communicatively coupled to the user, for example, in contact with the user, closest to the user's body 43 201208643, and most in communication with the user. Proximity, etc. In one aspect, the detector 20 can be disposed on the user's body to detect muscle movement associated with the user's 10 swallowed dose. Depending on the location and in the location The position of the electrode or the contact area of the user's body is considered, and an additional swallow detection technique is considered. As explained above, the detector 20 is a detector located outside the user. In another aspect, the detector 20 can be positioned or implanted within the user, particularly in relation to tongue movement associated with swallowing motion. For example, during a swallowing motion, the tongue moves upward toward the upper jaw. Therefore, the detector 20 or the contact area connected to the detector can be positioned to detect the movement to confirm the swallowing action. In another aspect of the present invention, the detector 20 can Partial planting In the body of the user, the in vitro robust detector 20 of the present invention includes such devices that are suitably sized and stably coupled to a living body in a manner that does not substantially impinge upon movement of the living body. For its part, the detector 20 can have dimensions that, when secured to the user 10, will not cause the user 10 to experience any differences in comfort, mobility or movement. Figure 12B One aspect of the medical delivery device 400 is shown for delivering a single pill from a pill reservoir. The device 400 includes a housing 402 having a chamber 404 (reservoir or container) portion for storing a plurality of A single pill 406, and a delivery tube 408 or device are used to deliver a single pill dose 406a. The user 10 holds the device 400 in its hand and places the device 400 at its mouth to contact the device 400 at at least two locations. The user 10 then activates a pill delivery mechanism for 201208643 to deliver a prescribed pill dose 406a into the delivery tube 408. Although the device 400 is shown to deliver a single dose of 4〇6a, the device can be designed or configured to deliver a plurality of pill doses according to a prescription medication. For young children, the parent can hold the device 400. In different perspectives, if the child is in contact with the parent, follow the instructions below to complete a circuit through the parents and the child. To clearly illustrate its functionality and the components therein, the device 400 is shown in block diagram form. However, according to the different viewpoints of the present invention, the device 400 can be constructed in a plural shape. For example, in one aspect, the device 400 can be designed or configured to deliver a suppository in the rectum of the user. Therefore, the detector 2 can be configured in a manner to detect the delivery of the actual suppository dose. Figure 12C illustrates an aspect of the medical delivery device 400 for delivering a single pill from a pill reservoir. The device 400 illustrated in Figure 12C includes a housing 402 having a chamber 404 (reservoir or container) portion for storing a plurality of individual pills 406, and a delivery tube 408 or device for A single pill dose 406a is delivered. The device 400 further includes an actuator 410 operatively coupled to a pill valve 416 port or a latch mechanism for controlling delivery of the single pill dose 406a via the pill valve 416, which may be electrically, mechanically Or act mechanically. In a different opinion, the actuator 410 can include a mechanical button, lever or magazine with the port 416 such that the user contacts the actuator to cause the valve 416 to deliver the single drug nine dose 406a. In other aspects, the actuator can include an electromechanical or electrical button or switch that is electronically coupled to the electric pill valve 416 to cause contact with the actuator 410. 201202643 Bioelectronic control (four) σ 416 or the position of the flash lock to deliver the single pill dose of 4 嶋. Mechanical, electrical, electronic and/or electromechanical actuation mechanisms can be considered, and the other and/or four (4) mechanisms are used to precisely control the delivery of the pill dose, usually as a pill, but can be configured It is also possible to control the delivery of a plurality of pill doses. Also shown in Figure UC is at least two contact regions 412 and 414 that are electrically coupled to the device 2G via the user's body. The user 1 holds the device 40"G in its hand and places the device_ to the user's mouth so that the first contact 412 is in contact with the user's mouth and the first contact 4M The user's hand contacts, thereby contacting the device shed at at least the position 'as shown. The user 1() then initiates a pill delivery to deliver a prescription or a predetermined pill dose 槪a into the delivery tube 408. 13 Thus, as explained above, the at least two contact regions 412, 414 are Connected to a power source such that when the user is in contact with each of the two contact regions 412 414, a circuit and a current path are completed and detected by the detector 2 coupled to the user 10 A current flows. Figure 12D illustrates one aspect of the medical delivery device 4 for delivering a single pill from one of the individual sealed pills. The device 400 illustrated in Figure 12D includes a housing 402 having a chamber 404 (reservoir or container) portion for storing a plurality of individually sealed pellets 406 in a sealed package 418 (for clarity) In the dotted line, a delivery tube 408 or device is used to deliver a single pill dose 406a. The device 400 further includes an electric pill valve 420 that, when activated by an actuator mechanism 410 (not shown) as illustrated in relation to Figure 12C, is an electric pill
S 46 201208643 單—藥丸劑量4Q6a之輸送,並同時在將單一 "自二包二:送進入該輸送管408之前,將該藥丸4。如 自》亥雀封包裝418取出。該审封七酤j 封藥丸406保持在任何需要.^ 將複數的個別密 斤田㈣^ %境下,例如乾燥且密封的 心用以保持樂丸楊新鮮且能夠將對冷藏之需求降至最 低。於其他觀點,該外殼術,更特定言之以及該腔室彻, 可經密_致其僅在輸送該單—藥丸劑量4·期間且短暫 地對該裱境開啟,而其他藥丸維持密封。 於圖12D中亦圖示至少二接點區域412及414立係婉 由該使用者身體與該偵測H 2G賴合。錢用者ι〇、將= 裝置働握持於其之手中並將該裝置_放置至該使用者 之口 ’從而使該第-接點412與使用者之〇接觸以及該第 -接點414與使用者之手接觸,藉此與該裝置權於至少 :二處接觸,如圖所示。該使用者1〇接著啟動藥丸輸送 處方或是财的藥丸劑量⑽輸送進入該輸 414em因此,如以上所說明,該至少二接點區域412、 ^係^接至—㈣減t鞭用者與,輕朗2、414 時完成一電路以及因之的1流路徑,並且 措用者10柄合的偵測器20蛛電流流動。 見圖13Α ’顯示該使用者1〇配戴一娜2〇以 及與一裝置_作身體上魏。該裝置5 輸 ^納在-密封的膠帶捲包Μ為藥丸、藥片或是膠囊(藥 =之=㈣藥。2G係顯示h在該使用者身 奴上h立置處’並係通訊上與該使用者ι〇輛合,並如以 201208643 上所說明地,能夠偵測通過該使用者身體的電流流動。 圖13B圖示該醫藥輸送裝置500之一觀點,用於由包 含複數之密封於其中之藥丸的一膠帶504中輪送一單個的 藥丸。該裝置500包含一外殼502’其界定一腔室510用於 保存其中包含複數之密封樂丸的膠帶504。一旦使用複數之 技術’例如,如以下所說明,自該膠帶504取出該藥丸, —藥丸輸送管508即輸送一單個的藥丸劑量至該使用者 10。如圖13C中所示’例如,該膠帶504可包含複數之密 封於一包裝中的複數藥丸506’其能夠經盤捲並插入於該腔 室510内。該裝置500可使用複數之先進的機構,用以根 據一處方醫藥計畫輸送一單一劑量或是複數劑量。該使用 者10將該裝置500握持於其之手中並將該裝置5〇〇置於其 之口,從而在至少二位置處與該裝置500接觸。該使用者 10接著啟動一刀與捲動輸送機構用以將一處方或是預定的 藥丸劑量輸送進入该輸送管508。就幼童而言,父母可握持 该裝置500。於不同的觀點中,假若孩童與父母接觸,則如 以下說明,經由父母與孩童完成一電路。為了清楚地說明 其之功能性以及其中組件,該裝置500係以方塊圖形式顯 不。然而,根據本發明之不同的觀點,該裝置5〇〇能夠構 成為複數的形狀。 •圖圖示6亥醫藥輪送裝置5〇〇的一觀點,用於由包 含複數之密封於其中之藥丸的一膠帶5〇4中輸送一單個的 藥丸。該圖13D中所圖示的裝置5〇〇係相對於該使用者1〇, 顯示一刀512係配置在該輸送管5〇8的一末端部分處。該S 46 201208643 Single-pill dose 4Q6a delivery, and at the same time the pellet 4 is sent before the single "two packs two: into the delivery tube 408. Take out from the haique seal package 418. The seal of the seven 酤 j 封 pills 406 is kept in any need. ^ will be a plurality of individual jintian (four) ^%, such as a dry and sealed heart to keep Le Yang Yang fresh and able to reduce the need for refrigeration lowest. In other respects, the outer shell, and more specifically the chamber, may be so tight that it is only opened during the delivery of the single-pill dose 4· and the other pills remain sealed while the other pills remain sealed. Also shown in Fig. 12D is at least two contact regions 412 and 414 that are responsive to the detected H 2G by the user's body. The money user ι〇, will hold the device 其 in its hand and place the device _ to the mouth of the user such that the first contact 412 is in contact with the user and the first contact 414 Contact with the user's hand, thereby at least two contacts with the device, as shown. The user then initiates a pill delivery prescription or a pill dose (10) to be delivered into the transfusion 414em. Thus, as explained above, the at least two contact regions 412, ^ are connected to - (four) minus t whip users and When the light is 2, 414, a circuit and a 1 flow path are completed, and the detector 20 of the user handles the flow of the spider. See Figure 13Α' to show that the user is wearing a 〇2〇 and a device _ for the body. The device 5 is loaded into a sealed bag of tape, which is a pill, a tablet or a capsule (medicine===4). The 2G system shows that h is placed on the user's body and is in communication with The user can illuminate the vehicle and, as explained on 201208643, can detect the flow of current through the body of the user. Figure 13B illustrates one of the points of the medical delivery device 500 for sealing by a plurality of A single pill is rotated in a strip 504 of the pill. The device 500 includes a housing 502' that defines a chamber 510 for holding a tape 504 containing a plurality of sealed pellets. The pill is removed from the tape 504 as described below, and the pill delivery tube 508 delivers a single pill dose to the user 10. As shown in Figure 13C, for example, the tape 504 can comprise a plurality of seals. A plurality of pills 506' in a package can be reeled and inserted into the chamber 510. The device 500 can use a plurality of advanced mechanisms for delivering a single dose or multiple doses according to a prescription medical plan. Use 10 holding the device 500 in its hand and placing the device 5 at its mouth to contact the device 500 at at least two locations. The user 10 then activates a knife and scroll transport mechanism for A prescription or a predetermined dose of the pill is delivered into the delivery tube 508. In the case of a young child, the parent can hold the device 500. In different perspectives, if the child is in contact with the parent, as described below, via the parent and The child completes a circuit. The device 500 is shown in block diagram form in order to clearly illustrate its functionality and its components. However, in accordance with various aspects of the present invention, the device 5 can be constructed in a plurality of shapes. • Figure 6 is a view of a 6th medical delivery device for transporting a single pill from a strip of adhesive 5〇4 containing a plurality of pills sealed therein. The device illustrated in Figure 13D 5〇〇 relative to the user 1〇, a knife 512 is arranged at one end portion of the conveying pipe 5〇8.
S 48 201208643 刀512係經組構以當該膠帶504為了輸送一正確的藥丸劑 量至該使用者10而機械地前進時,將該藥丸506自該膠帶 504捲包裝剝下。可使用其他的機械裝置用以打破該膠帶 504之包裝並釋放該藥丸506。於一觀點中,該包裝捲及刀 512機構可為電子互鎖方式,用以防止過度的劑量。於一觀 點中’膠帶指示器514的-端部顯示當該醫藥係接近完成 時及/或當一記錄器日期係為到期時。 應察知的疋該膠帶醫藥輸送構形並未限制在保持一藥 丸。如於圖13E及13F中所示,例如,其中圖13£係為一 俯視圖以及圖13F係為用於輸送液體醫藥的—膠帶522輸 运機構的-側視圖。如於圖13E、13F中所示,該膠帶似 包括個別密封的小袋524。每一袋之液體醫藥劑量526係經 密封在該等小袋、524之内部,並且每一袋充滿液體醫藥526 係經個別地密封並附|至一共同的膠帶522用於輸送。一 機械裝置’諸如該刀Sl2(圖13D)打破該小袋5 體醫藥526經由該輪送筝弋θ甘从仙 ^ 508或疋其他機構輸送至該使用 者1U。S 48 201208643 The knife 512 is configured to peel the pill 506 from the tape 504 when the tape 504 is mechanically advanced to deliver the correct pill dose to the user 10. Other mechanical means can be used to break the package of the tape 504 and release the pill 506. In one aspect, the package roll and knife 512 mechanism can be electronically interlocked to prevent excessive dose. In the point of view, the end of the tape indicator 514 is shown when the medical system is near completion and/or when a recorder date is expired. It should be noted that the medical delivery configuration of the tape is not limited to maintaining a pill. As shown in Figs. 13E and 13F, for example, Fig. 13 is a plan view and Fig. 13F is a side view of a tape 522 transport mechanism for transporting liquid medicine. As shown in Figures 13E, 13F, the tape appears to include an individually sealed pouch 524. Each bag of liquid medical dose 526 is sealed within the pouches 524, and each bag filled with liquid medicine 526 is individually sealed and attached to a common tape 522 for delivery. A mechanical device 'such as the knife Sl2 (Fig. 13D) breaks the pouch 5 body medicine 526 via the wheel to send the kite θ 甘 from the ^ 508 or other mechanism to the user 1U.
於一觀點中’於圖13A、13c及13D 兮笪闰彳士丨V约日日ΛΑ 4 久UD中顯不亚相關於 该專圖式加以說月的錢置獲包含内嵌於 504中的可溶解醫藥劑量篇。因此,當解巧 械方式前進時,該刀Sl2 ▼ 係以機 並使該滕帶遍包裝讀的醫藥劑量鄕分開 儘管未明確地顯示,但為了揭 ηΑ Ά ^ #的清晰性,應瞭 解的疋於圖BA及13D中顯示並相關於該等圖式加以說明 49 201208643 的該裝置5〇〇包含至少— 4骑淑兮^丨。。 接點£域,並係經由該使用者的 身體與a亥偵測态20電耦合。如以卜 域可與該使用者電容性Μ ° ’敍少二接點區 q电谷注耦合。因此,於一 點區域可介電材料塗覆,諸如 並^ ===;電容性輕合而完成該電氣通訊:假若 ===電材料所覆蓋,則該裝置與該使用者 該等電極可内嵌在該塑膠材有有見州 -^ ^ 2胗柯枓中以及使用電容性耦合並 二ϋ m ^ 口與該二平板接觸時所出現的二電容平板 間阻抗的交化而感應使用者之口的存在。可在大於約2·ζ 的信號頻率下完成電容性輕合’並且於—些觀點中約為 80kHz對於信噪比(SNR,例如,信號與周圍噪音)係為良好 的《亥使用者1 〇將5亥裝置5〇〇握持於其之手中並將該裝置 500安置至其之口 ’從而使一第一接點區域與該使用者之口 接觸以及一第二接點區域與該使用者之手接觸,因此與該 裝置500至:>、在一位置處接觸,如圖所示。該使用者1 〇接 著啟動一捲包與刀輸送機構,將一處方或預定的藥丸劑量 送入該輸送管508。因此,如以上說明,該至少二接點區域 係連接至一電源以致當該使用者與二接點區域之每—者接 觸時完成一電路以及因之的一電流路徑,並且藉由與該使 用者10耦合的偵測器20偵測一電流流動。 現參考圖14A,圖中顯示該使用者1〇配戴一偵測器2〇 並與一裝置600作身體接觸。裝置600係經構形用於輪送 容納在一密封膠帶捲包裝中的液體及一藥丸、藥片或是膠 50 201208643 囊(藥丸)之一結合形式的醫藥。該偵測器2〇係顯示固定在 該使用者身體上的一位置處,並係與該使用者1〇作通訊上 耦合並且能夠偵測通過該使用者身體的一電流流動,如以 上所說明。 _圖14B圖示該醫藥輸送裝置600的一觀點,用於自包 含複數之藥丸密封於其中的一膠帶6〇4輸送一單個的藥 丸,而亦能夠輸送一液體614之劑量。該液體614可為水 或液體醫藥。於-觀點中,該液體614可為一雙組份液體 醫藥,其中當輸送醫藥時藉由在活體内的反應及/或控制= 局部pH而產生或啟動有療效的分子。該裝置6〇〇包^一 ^ 殼602’其界定-第-腔室⑽用於健其中包含複數 封藥丸的膠帶604,以及一第二腔室6〇6係由一壁612所乂 隔。該第二腔室606保持該液體614。一旦使用複數之ς 術,例如,如以下所說明,自該膠帶6〇4取出該藥 一 輸送管608即輸送與該液體614結合二 至該使用者H)。該膠帶604可包含複數之密封於二:: 的複數藥丸,其能夠經盤捲並插入於該腔室61〇匕衷: 置働可使用複數之先進的機構,用以根據—處方醫$ 畫輸运一早一劑量或是複數劑量。就幼童而言,,、孙〃。 持该裝置600。該使用者1〇將該裝置6〇〇握持於可握 並將該裝置_安置至其之σ,從而與該u = -位置處接觸。於不同峨財,假若孩童 乂 則如以下說明,經由父母與孩童完成H 了3 ’ 說明其之功雛以及其中組件,難置_如方^= 51 201208643 式顯示。然而,根據本發明之不同的觀點,該裝置600能 夠構成為複數的形狀。 儘管未明確地顯示,但為了揭示内容的清晰性,應瞭 解的是於圖14A及14B中顯示並相關於該等圖式加以說明 的該裝置600包含至少二接點區域,並係經由該使用者的 身體與該偵測器20電耦合。該使用者10將該裝置600握 持於其之手中並將該裝置600安置至其之口,從而使一第 一接點區域與該使用者之口接觸以及一第二接點區域與該 使用者之手接觸,因此與該裝置600至少在二位置處接觸, 如圖所示。該使用者10接著啟動一捲包與刀輸送機構,將 一處方或預定的藥丸劑量送入該輸送管608,並接著能夠使 該外殼602傾斜用以釋放液體614之一劑量,吞下該藥丸 劑量。因此,如以上說明,該至少二接點區域係連接至一 電源以致當該使用者與二接點區域之每一者接觸時完成一 電路以及因之的一電流路徑,並且藉由與該使用者10耦合 的偵測器20偵測一電流流動。 現參考圖15A,圖中顯示該使用者10配戴一偵測器20 並與一裝置700作身體接觸。裝置700係經構形用於輸送 容納在一密封膠帶捲包裝中的液體及一藥丸、藥片或是膠 囊(藥丸)之一結合形式的醫藥。該偵測器20係顯示固定在 該使用者身體上的一位置處,並係與該使用者10作通訊上 耦合並且能夠偵測通過該使用者身體的一電流流動,如以 上所說明。 圖15B圖示醫藥輸送裝置700用於由一囊袋716(例In one point of view, 'in Figures 13A, 13c, and 13D, the gentleman's 丨V is about 日 久 久 久 久 UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD Soluble pharmaceutical dosages. Therefore, when the tool advances, the knife Sl2 ▼ is used to separate the medicine dose from the package, although it is not explicitly displayed, but it should be understood in order to reveal the clarity of the Α Α # ^ # The device shown in Figures BA and 13D and related to the drawings is described in the description of the Japanese Patent Application No. 49 201208643. . The contact field is electrically coupled to the a-detection state 20 via the user's body. For example, the user can be coupled with the capacitive region of the user. Therefore, the dielectric material can be coated in a little area, such as ^===; the capacitive communication is completed to complete the electrical communication: if the === electrical material is covered, the device and the user can be inside the electrode Embedded in the plastic material, there is a state--^^2胗柯枓中 and the use of capacitive coupling and the two-dimensional m ^ port and the two plates are in contact with the two plates when the impedance of the two capacitors is intertwined to sense the user The existence of the mouth. The capacitive coupling can be done at a signal frequency greater than about 2·ζ and in some respects about 80 kHz is good for the signal-to-noise ratio (SNR, for example, signal and ambient noise). Holding the 5 hai device 5 〇〇 in its hand and placing the device 500 to its mouth' so that a first contact area contacts the user's mouth and a second contact area and the user The hand is in contact, thus contacting the device 500 to: > at a location as shown. The user 1 splicing a roll and knife transport mechanism to deliver a prescribed or predetermined pill dose to the delivery tube 508. Therefore, as explained above, the at least two contact regions are connected to a power source such that when the user contacts each of the two contact regions, a circuit and a current path are completed, and by using the same The 10 coupled detector 20 detects a current flow. Referring now to Figure 14A, the user 1 is shown wearing a detector 2 and in physical contact with a device 600. The device 600 is configured to circulate a liquid contained in a sealed tape roll package and a medicine in the form of a combination of a pill, a tablet or a gel 50 201208643 capsule (pill). The detector 2 is displayed at a position fixed on the user's body and is communicatively coupled to the user 1 and is capable of detecting a current flow through the user's body, as explained above. . Figure 14B illustrates a point of view of the medical delivery device 600 for delivering a single pill from a tape 6〇4 in which a plurality of pills are sealed, and capable of delivering a dose of liquid 614. The liquid 614 can be a water or liquid medicine. In the opinion, the liquid 614 can be a two-component liquid medicine in which a therapeutic molecule is produced or activated by reaction and/or control in the living body = local pH when the medicine is delivered. The device 6 includes a shell 602' defining a -th chamber (10) for holding a tape 604 containing a plurality of pills, and a second chamber 6 6 being separated by a wall 612. The second chamber 606 holds the liquid 614. Once a plurality of techniques have been used, for example, as described below, the drug is removed from the tape 6〇4, i.e., the delivery is combined with the liquid 614 to the user H). The tape 604 can comprise a plurality of plural pills sealed in two:: which can be coiled and inserted into the chamber 61. The use of a plurality of advanced mechanisms can be used to draw according to the prescription medicine Transport one dose a day or multiple doses. As far as young children are concerned, Sun Wei. The device 600 is held. The user 1 holds the device 6 于 grip and holds the device _ to its σ to contact the u = - position. For different wealth, if the child is 乂, as described below, through the parents and children to complete the H ’ description of its squad and its components, it is difficult to set _ such as ^ ^ 51 201208643 style display. However, the device 600 can be constructed in a plurality of shapes in accordance with various aspects of the present invention. Although not explicitly shown, in order to reveal the clarity of the content, it should be understood that the apparatus 600 shown in Figures 14A and 14B and described in relation to the figures includes at least two contact areas via which The body of the person is electrically coupled to the detector 20. The user 10 holds the device 600 in its hand and positions the device 600 to its mouth, thereby bringing a first contact area into contact with the user's mouth and a second contact area and the use. The hand is in contact and thus contacts the device 600 at least at two locations, as shown. The user 10 then activates a roll of package and knife transport mechanism to deliver a prescribed or predetermined dose of the pill into the delivery tube 608 and can then tilt the outer casing 602 to release a dose of the liquid 614 to swallow the pill. dose. Therefore, as explained above, the at least two contact regions are connected to a power source such that when the user contacts each of the two contact regions, a circuit and a current path are completed, and by using The 10 coupled detector 20 detects a current flow. Referring now to Figure 15A, the user 10 is shown wearing a detector 20 for physical contact with a device 700. Device 700 is configured to deliver a medicament in a combination of a liquid contained in a sealed tape roll package and a pill, tablet or capsule (pill). The detector 20 is shown in a position fixed to the user's body and is communicatively coupled to the user 10 and is capable of detecting a flow of current through the body of the user, as explained above. Figure 15B illustrates the medical delivery device 700 for use by a pocket 716 (eg
S 52 201208643 如’可撓曲的小袋、袋子等)輸送一個別劑量之液體醫藥 704。戎裝置7〇〇包含一外殼7〇2,其界定一腔室71〇用以 保持填注該液體醫藥7〇4的該囊袋716。一加壓機構7〇6 以一預定量加壓該囊袋716,用以經由流量閥712輸送—相 對應劑量之液體醫藥7〇4至該輸送管7〇8。該加壓機構7〇6 可包含液壓、氣動、機械式、活塞、步進馬達、伺服馬達 或是任何其他適合的機構,用以施壓至該囊袋716之外在 部分’為了強制一對應劑量之液體醫藥704流動進入該輪 送管708。於一觀點中,如圖所示,該加壓機構包含與 一可移動平板718耦合的一可移動活塞720。該活塞720 推進§亥平板718用以對該囊袋716之外在部分施麼,以及 縮回該平板718用以將壓力自其去除。該活塞720可為液 壓地、氣動地、機械地、機電地、電子地、藉由步進馬達, 或藉由伺服馬達移動。該活塞720可以一導螺桿加以取代, 其與一馬達(步進或是伺服馬達)耦合用以推進或是縮回該 平板718。該加壓機構706可與一機械或電氣式致動器耦 合。該使用者10將該裝置700握持於其之手中並將該裝置 700之該輸送管708放置至該使用者之口,從而使該裝置 700於至少二位置處接觸。該使用者10接著啟動致動器用 以將一處方或是預定劑量的液體醫藥704輸送進入該輸送 管708。該使用者1〇接著將液體吸入他或她之口。在吸入 動作期間,空氣經由該通氣孔714進入並在該液體醫藥704 之後引進該輸送管708中’用以強制該液體醫藥704進入 該使用者之口。於不同的觀點中,假若該小孩與父母接觸, 53 201208643 則如以下所說明,經由該父母與小孩完成—電路。為了支 楚地說明該裝置之功能性及其中的該等組件,以方塊圖= 形式顯示該裝置700。然而,根據本發明之不同的觀點,該 裝置700可以構成為多種的形狀。 ” 儘管未明確地顯示’但為了揭示内容的清晰性,應瞭 解的是於圖15Α及15Β中顯示並相關於該等圖式加以說明 的該裝置700包含至少二接點區域’並係經由該使用者的 身體與該偵測器20電耦合。該使用者1〇將該穿置7〇〇 持於其之手中並將該裝置700安置至其之口 :彳^而使 —接點區域與該使用者之口接觸以及-第二接點區物 使用者之手接觸,因此與該裝i 500 1少在二位置處接觸: 如圖所示。因此’如以上說明’該至少二接點區域係連接 至一電源以致當該使用者與二接點區域之每—者接觸時完 成一電路以及因之的一電流路徑’並且藉由與該使用者= 耦合的偵測器20偵測一電流流動。 於圖12A-15B中顯示並相關於該等圖式說明的該等裝 置400、500、600、700可包括如於圖2A及2B中顯示並 相關於該等圖式說明的一電源34、一控制單元36、接點區 域38、40以及一記憶體單元42。根據以上說明的該等觀 點,該個別裝置400、500、600、700包括至少二接點區域 /點38、40(與圖12C、12D中接點區域412、414相對應) 配置在該外殼上的不同位置處。藉由該裝置3之形狀及設 計以及根據本發明之不同的觀點確定該等接點38、40或區 域之處所與位置。針對該等接點區域38、40,可考量複數S 52 201208643 A different dose of liquid medicine 704 is delivered as in a flexible pouch, bag, or the like. The fistula device 7A includes a housing 7〇2 that defines a chamber 71 for holding the pouch 716 filled with the liquid medicine 7〇4. A pressurizing mechanism 7〇6 pressurizes the bladder 716 with a predetermined amount for delivering a corresponding dose of the liquid medicine 7〇4 to the delivery tube 7〇8 via the flow valve 712. The pressurizing mechanism 7〇6 may comprise a hydraulic, pneumatic, mechanical, piston, stepper motor, servo motor or any other suitable mechanism for applying pressure to the portion of the pocket 716 in order to force a correspondence The dose of liquid medicine 704 flows into the wheel tube 708. In one aspect, as shown, the pressurizing mechanism includes a movable piston 720 coupled to a movable plate 718. The piston 720 advances the slab 718 for application to the outer portion of the pocket 716 and retracts the plate 718 for removal of pressure therefrom. The piston 720 can be hydraulically, pneumatically, mechanically, electromechanically, electronically, by a stepper motor, or by a servo motor. The piston 720 can be replaced by a lead screw that is coupled to a motor (stepper or servo motor) for propelling or retracting the plate 718. The pressurizing mechanism 706 can be coupled to a mechanical or electrical actuator. The user 10 holds the device 700 in its hand and places the delivery tube 708 of the device 700 to the user's mouth, thereby causing the device 700 to contact at at least two locations. The user 10 then activates an actuator to deliver a prescription or predetermined dose of liquid medication 704 into the delivery tube 708. The user then draws liquid into his or her mouth. During the inhalation action, air enters through the vent 714 and is introduced into the delivery tube 708 after the liquid medication 704 to force the liquid medication 704 into the mouth of the user. In different perspectives, if the child is in contact with the parent, 53 201208643 completes the circuit via the parent and child as explained below. To clearly illustrate the functionality of the device and the components therein, the device 700 is shown in block diagram form. However, the device 700 can be constructed in a variety of shapes in accordance with various aspects of the present invention. "Although not explicitly shown", in order to reveal the clarity of the content, it should be understood that the device 700 shown in Figures 15A and 15A and described in relation to the drawings includes at least two contact regions 'and via The user's body is electrically coupled to the detector 20. The user 1 holds the device 7 in its hand and places the device 700 at its mouth: 彳^使—contact area and The user's mouth contact and the second contact area user's hand contact, so contact with the installation i 500 1 at two locations: as shown. Therefore 'as explained above' the at least two contacts The area is connected to a power source such that when the user contacts each of the two contact areas, a circuit and a current path are completed and detected by the detector 20 coupled to the user = The current flows. The devices 400, 500, 600, 700 shown in Figures 12A-15B and described in relation to the figures may include a power source as shown in Figures 2A and 2B and described in relation to the figures. 34. A control unit 36, contact areas 38, 40, and a memory list Element 42. According to the above-described point of view, the individual devices 400, 500, 600, 700 include at least two contact regions/points 38, 40 (corresponding to the contact regions 412, 414 in Figures 12C, 12D) Different locations on the outer casing. The locations and designs of the contacts 38, 40 or regions are determined by the shape and design of the device 3 and from the different perspectives of the present invention. For the contact regions 38, 40, Can consider plural
S 54 201208643 位置。 根據本發明之另一觀點’該等接點區域38、4〇(與圖 12C、12D中接點區域412、414相對應)可包括考慮到生物 認證資訊,諸如指紋資料之讀取及記錄的功能性。此資$ 可傳達至該裝置400、500、600、700並儲存於其中,供使 用者之身分確認所用。 該等接點區域38、40(與圖12C'12D中接點區域412、 414相對應)係相互電隔離並且至少部分地露出或是可露 出,使該使用者1〇與之接觸。根據本發明之一觀點,兮等 接點區域38、40係經定位以致一接點區域38,例如,與使 用者的手接觸’以及另一接點區域40,例如,與使用者的 口接觸。根據本發明之可任擇的觀點,可增加附加的接$ 區域,用以考慮到與手或口的第二接觸以及使用一不同的 手谷納’諸如同時一左手握抓或是一右手握抓。再者,可 包括位在外殼402、502、602、702上的附加接點區域,用 以確保該裝置400、500、600、700係經正確地握持。 於圖12A-15B巾顯示並相關於該等圖式說明的該 置400、500、600、700可包含一或是多於一的感應器用 於偵測該單-劑量藥丸406 a輸入該使用者! 〇之口。例如, 在以上論及的其他感應器外,感應器可包括偵測液體、唾 液、:濕氣、當藥丸於口七容解時著色的變化、真空壓力、 傳導性、音響。在其他的非接觸感應器之類型外,該等感 應器可包㈣加的接點區域’用於電容軸合並偵測使用 者與裝置働_,電_合躲非接跑貞測最接近該使 55 201208643 用者 將該债測除了其他位置外’可藉由適當地 配置在該編搞合的電極(例如,接點區域) 腫、脖子 1G之身體上的不同位置處’諸如軀幹、胸 與吞。燕動作:1上顎’而可❹_動作,用以價測 的-電子罐?聯肌肉運動。於其他的觀點中,配備電極 兮㈣盗可用以偵測輸送一藥丸劑4 4〇6a或是吞瑞 :立咸::4〇如。如以上所論及’例如,亦可利用適合的 曰名…益偵測在吞嚥之動作期間所發出之聲音。於其他 的觀點中,脫氧核糖核酸(舰)偵測技術,諸如光學Dna 偵測亦可用以偵測輸送該單一藥丸劑量406a至該使用者 10。 、於不同的繞點中,於圖12A-15B中顯示並相關於該等 圖式說明的該等裝置400、500、600、700可包含機械的、 電子的、及/或機電的方式控制僅在規定的安排時間時輪送 醫藥’並且僅輸送規定之量用以預防施用劑量過度。例如, 可將一閉鎖機構與醫藥輸送裝置400、500、600、700結合, 讓該使用者無法侵入外殼用以在已輸送一正確劑量後在規 定的時段外取得該醫藥。例如,僅在早上配送的藥丸無法 在下午配送並且該使用者無法侵入外殼或是以其他方式進 入該腔室、藥丸貯藏處或貯存器而取得該醫藥。 於該等觀點中,當藉由於圖12A-15B中顯示並相關於 該等圖式說明的該等醫藥輸送裝置400、500、600、700輸 送一 IEM時,該iem產生其之自有電力並與該偵測器20(例 如,圖 ΙΑ、3A、3E、5A、10、12A、13A、14A、15A)連S 54 201208643 Location. According to another aspect of the present invention, the contact regions 38, 4 (corresponding to the contact regions 412, 414 in Figures 12C, 12D) may include consideration of biometric authentication information, such as reading and recording of fingerprint data. Feature. This $ can be communicated to the device 400, 500, 600, 700 and stored therein for the identity of the user to confirm. The contact regions 38, 40 (corresponding to the contact regions 412, 414 in Figures 12C'12D) are electrically isolated from each other and are at least partially exposed or exposed to allow the user 1 to contact. According to one aspect of the invention, the contact regions 38, 40 are positioned such that a contact region 38, for example, is in contact with the user's hand and another contact region 40, for example, in contact with the user's mouth. . According to an optional aspect of the present invention, an additional area can be added to take into account a second contact with the hand or mouth and to use a different hand-negative 'such as a left-handed grip or a right-handed grip Grab. Further, additional contact areas on the outer casings 402, 502, 602, 702 can be included to ensure that the devices 400, 500, 600, 700 are properly held. The device 400, 500, 600, 700 shown in Figures 12A-15B and associated with the drawings may include one or more sensors for detecting the single-dose pill 406a input to the user ! The mouth of the mouth. For example, in addition to the other sensors discussed above, the sensor may include detecting liquid, saliva, moisture, coloration changes when the pill is in place, vacuum pressure, conductivity, sound. In addition to the types of other non-contact sensors, the sensors can be packaged with (4) plus contact areas for the capacitive axis to detect the user and device 働 _, the electric _ 躲 非 非 最 最 最 最Let 55 201208643 users measure the debt except for other positions' by appropriately arranging at the different positions on the body of the braided electrode (for example, the contact area) swollen, neck 1G 'such as torso, chest With swallowing. Swallow action: 1 颚 而 而 ❹ _ action, used for price measurement - electronic cans? Joint muscle exercise. In other points of view, equipped with electrodes 四 (4) thieves can be used to detect the delivery of a pill 4 4 〇 6a or swallow: Li Xian:: 4 〇. As discussed above, for example, it is also possible to detect the sound emitted during the swallowing action using a suitable nickname. In other views, DNA detection techniques, such as optical DNA detection, can also be used to detect delivery of the single bolus dose 406a to the user 10 . Among the different winding points, the devices 400, 500, 600, 700 shown in Figures 12A-15B and described in relation to the figures may include mechanical, electronic, and/or electromechanical controls only The medicine is "delivered at the prescribed time" and only a prescribed amount is delivered to prevent overdosing. For example, a latching mechanism can be combined with the medical delivery device 400, 500, 600, 700 to prevent the user from intruding into the housing for obtaining the medication outside of a specified period of time after a correct dose has been delivered. For example, a pill delivered only in the morning cannot be dispensed in the afternoon and the user cannot invade the outer casing or otherwise enter the chamber, pill storage or reservoir to obtain the medicine. In such a view, when an IEM is delivered by the medical delivery devices 400, 500, 600, 700 shown in Figures 12A-15B and described in relation to the figures, the iem generates its own power and Connected to the detector 20 (eg, maps, 3A, 3E, 5A, 10, 12A, 13A, 14A, 15A)
S 56 201208643 通並藉由改變傳導性導致該電流流動之特性的改變。該等 改變的特性包含編碼在該電流流動中的資訊,如於2009年 9月21日提出申請的美國專利申請案第12/564,〇17號,標 題為具有部分電源的通訊系統令所揭示者,該申請案公開 為US 2010/0081894,該整個說明書於此併入本案以為參考 資料。該編碼資訊因而由該偵測器2〇所偵測並解碼。此外, 於2006年4月28曰提出申請的美國專利申請案第 11/912,475號’標題為製藥資訊學系統 (PHARMA-INFORMATICS SYSTEM)中揭示資訊,並公開 為US 2008/0284599其之整個說明書係併入本案以為參考 資料。 因此’於一觀點中,於圖12A-15B中顯示並相關於該 等圖式說明的該等醫藥輸送裝置400、500、600、700係經 組構以輸送一 IEM系統,用於指示一事件的發生,諸如指 示一醫藥劑量已由該使用者10吞嚥。於一觀點中,該 系統係搭配一傳導性流體使用’用以指示藉由該傳導性流 體與該IEM系統間的接觸標記的事件。例如,該IEM系統 可搭配藥產品使用,以及所指示的該事件係為當取用或吞 °燕該產品,以及該IEM系統係經引導至包含一傳導性流體 的一環境時。 當取用或是吞11 燕包括該IEM系統的該產品時,該裝置 與身體之傳導性流體接觸。當該IEM系統與該身體流體接 觸時’產生一電壓並且啟動該系統。電源的一部分係由該 裝置提供,而電源的另一部分係由該傳導性流體所提供。 57 201208643 包括一 IEM系統的一可吞嚥產品可經構形作為一藥丸 或膠囊形式的可口服吞嚥醫藥配方。一經吞爲,該藥丸移 動至胃。一經抵達胃,該產品即與胃液接觸並經歷與胃液 中的不同材料發生化學反應,諸如鹽酸及其他的消化劑。 儘管相關於醫藥環境討論該ΙΕΜ系統,但並未因而限^該 ΙΕΜ系統之該等揭示的觀點之範疇。該ιεμ系統能夠用在 存在或是經由混合二或更多產生一傳導性液體的成分而變 成存在一傳導性液體的任何環境中使用。 一醫藥產品可與一 ΙΕΜ系統或是一離子放射模組結 合。該ΙΕΜ系統使用電位差用以提供電力以及之後調制傳 導性用以產生一唯一的且可識別的電流信號。一經啟動, 該ΙΕΜ系統控制傳導以及電流流動用以產生該電流作號。 該編碼資訊因而由該偵測器20所偵測到並加以解碼。 於一特定的實例中’該ΙΕΜ系統與一醫藥產品結合, 當吞嚥該產品或是藥丸’啟動該ΙΕΜ系統。該ΙΕΜ系統控 制傳導性用以產生經偵測的一唯一的電流信號,從而表示 5亥醫藥產品已服用。該ΙΕΜ系統包括一框架,其使用作為 一底座供該ΙΕΜ系統使用,以及與之附裝的複數之成分, 沉積在該框架上或是固定至該框架。於此觀點中,一可吞 嚥材料係實體上與該框架結合。該材料可以化學沉積在該 框架上,在該框架上蒸發,固定至該框架或是裝配在該框 架上’該所有方式於此視為相關於該框架‘‘沉積,,。該材料 係沉積在該框架之一侧邊上。能夠使用作為材料的該等關 注之材料包括,但非限制在:Cu或Cul。除了其他協定外,S 56 201208643 Passing changes in the characteristics of the current flow by changing the conductivity. The characteristics of such changes include information encoded in the current flow, as disclosed in U.S. Patent Application Serial No. 12/564, filed on Sep. 21, 2009, which is incorporated herein by reference. The application is disclosed in US 2010/0081894, the entire disclosure of which is incorporated herein by reference. The encoded information is thus detected and decoded by the detector 2A. In addition, U.S. Patent Application Serial No. 11/912,475, filed on Apr. 28, 2006, the disclosure of which is incorporated herein in Incorporating this case into a reference. Thus, in one aspect, the medical delivery devices 400, 500, 600, 700 shown in Figures 12A-15B and described in relation to the figures are configured to deliver an IEM system for indicating an event. The occurrence, such as indicating that a medical dose has been swallowed by the user 10. In one aspect, the system is used in conjunction with a conductive fluid to indicate an event marked by contact between the conductive fluid and the IEM system. For example, the IEM system can be used with a pharmaceutical product, and the event indicated is when the product is taken or swallowed, and the IEM system is directed to an environment containing a conductive fluid. The device is in contact with the conductive fluid of the body when it is taken or swallowed to include the product of the IEM system. When the IEM system is in contact with the body fluid, a voltage is generated and the system is activated. A portion of the power source is provided by the device, and another portion of the power source is provided by the conductive fluid. 57 201208643 A swallowable product comprising an IEM system can be configured as an orally swallowable pharmaceutical formulation in the form of a pill or capsule. Once swallowed, the pill moves to the stomach. Upon reaching the stomach, the product comes into contact with the gastric juice and undergoes a chemical reaction with a different material in the gastric fluid, such as hydrochloric acid and other digestive agents. Although the system is discussed in relation to the medical environment, it does not limit the scope of such disclosures of the system. The ιεμ system can be used in any environment where there is or is a mixture of two or more components that produce a conductive liquid to become a conductive liquid. A pharmaceutical product can be combined with a system or an ion radiation module. The chirp system uses a potential difference to provide power and then modulate the conductivity to produce a unique and identifiable current signal. Once activated, the helium system controls conduction and current flow to generate the current. The encoded information is thus detected and decoded by the detector 20. In a particular example, the sputum system is combined with a medicinal product to activate the sputum system when swallowing the product or pill. The system controls conductivity to produce a unique current signal that is detected, thereby indicating that the 5H medical product has been taken. The crucible system includes a frame that is used as a base for the crucible system, and a plurality of components attached thereto, deposited on the frame or secured to the frame. In this view, a swallowable material is physically associated with the frame. The material may be chemically deposited on the frame, evaporated on the frame, secured to the frame or mounted on the frame. All of the ways herein are considered to be related to the frame 'deposition. The material is deposited on one side of the frame. Materials that can be used as materials of interest include, but are not limited to, Cu or Cul. In addition to other agreements,
S 58 201208643 °亥材料係藉由物理蒸咖 以沉積。該材料的厚度可自約=法或電滎沉積法加 約5至'約100微米厚。藉由降罩、約500微米,諸如自 ,該形狀。此外,即; 但每-系統可包含二或更多電氣“用於 >儿積讀料’ 其中可沉積該材料。上唯—區域,如有需要, 可消t::同其係為該相對侧,例如,沉積另-不冋側邊可為與針對〜。个’所選擇的 同側限制在所選擇的該側邊,以及該用語“不 一者。該n 先選擇⑼邊不同的倾側邊之任 等改液體,諸如體液接觸時,其一 ”得 ::料的所關注之材料包括,但不限定::= 將該(等)材料黏附至該框竿。供兮者層有助於 層係a钭,、仏忒(專)材料所用的典型黏著 雷二接:、乂、,各或是相似材料。可藉由物理蒸氣沉積法、 —"匕積法或是電毁沉積法沉積陽極材料及該黏著層。該第 ^(陽極)材料厚度可自約0_05至約5〇〇微米,諸如厚度自 了勺5至約1〇〇微米。然而,厚度或沉積製程並未限定在該 I系統之觀點或是用以將材料沉積或是固定至該框架的 该等材料之任一者。 59 201208643 根據〜觀點,該等 的任何成對之材料。此^材料可為具有不同電化學電位 内使用1等不同的材二’其中該1EM系統係為在有機體 定言之,該等不同的料可為能夠被吸收的維他命。更特 的任二材料構成。合該1EM系統運作的環境 等不同的材料係為可攝可攝食產品使用時,該 對之材料。―朗性]〜有Μ電鱗電㈣任何成 液,諸如胃酸,接觸Γ 當該1ΕΜ系統係與一離子溶 屬,並且於特定的具體適合的材料並未限制在金 非金屬選定,例如㈣巾,該成對·係由金屬及 或㈣組成的一成對:金^(諸如鎮)及一鹽(諸如cuC1 對之物質--金屬鹽材料有關’任何成 ^ 次甘入入化合物—具適合的不同電化學電 位(電堡)及低界面電阻,係為適合的。 晋 於不同的觀點中,於圖1Α、3Α、5Α、12Α_ΐ5Β^^ 並相關於該等圖式說明的料裝置3、25、3G、働、500、 600 7GG可包3 -跨導單元,其經配置與於圖2A、犯、 4A 4B及6A 6B中顯示並相關於該等圖式說明的一 單元州控制器、處理單元、處理器、狀態機)通訊。該跨 導單元包含相互電隔離的至少二接點區域,並經定位用以 容許與每一接點區域接觸,以及一電源。該至少一接點區 域係與該電源之一終端電耦合以及至少另一接點區域係與 該電源·之另終端電耗合。通過該使用者的身體完成一電 流路徑,容許當該使用者與該二接點區域之每一者接觸時 電流流動,並藉由該控制器偵測電流流動。 201208643 於一觀點中,該跨導單元進一步包含一控制模組其係 於该電源與該至少二接點區域之其中之一者間電連接。該 控制模組係經組構以將該該電流流動中的資訊編碼。 於一觀點中,該等裝置3、25、30、400、5〇〇、6〇〇、 7〇〇(如以上相關於圖iA_7C及圖12A-15B說明)可經構形用 以確s忍將一醫藥劑量輸送矣一使用者。該裝置包含至少二 相互電隔離的接點區域,,電源其包括一第一終端及第二 終端,其中至少一接點區域係與該第一終端電耦合以及至 少另一接點區域係與該第二終端電耦合’以及一控制模組 在該電源之該第一終端與其中之一接點區域之間電連接。 該控制模組係經組構以改變該使用者一經與該二接點區域 之母一者接觸即產生的一電流路徑之傳導性。當該使用者 與s亥一接點區域之每一者接觸時經由該使用者之身體完成 一電流路徑。該傳導性之變化將該電流流動中的資訊編碼。 所關注之偵測器包括,但非限定在,揭示於:PCT申 請案序號 PCT/US2006/016370 其公開為 WO 2006/116718 ; pct申請案序號PCT/2007/24225其公開為w〇 2008/063626 ; PCT 申請案序號 PCT/US2〇〇8/52845 其公開 為WO/2008/095183中的該等接收器;該等申請案之揭示内 容於此併入本案以為參考資料。 ―、根據本㈣之其他觀點,該純可包括二或更多(諸如 三或更多的,包括四或更多帽測器。於該等系統中,該 二或更多_11可適合地配置在該使用者之身體上的任何 需要位置處。例如’所有之與身體結合的制器可配置在 61 201208643 身體的相同側邊上, 身體的相對側邊上,二::的別軀幹,或是其可配置在 等特定的實例巾h °身幹之正面與背面。於該 該聲音單元33或::,自肺部内或圖4C之 其中該資訊係g早元31接收聲音資訊, 在躯幹周®,最^ 有關’因而該㈣測器係配置 獅、_ 7:近該肺部。於其他觀點中,與⑽^ 的一位置,用2G可配置在使用者身體上 根據本該使用者:之吞絲作。 計90,監親麻!另一觀點,其中該偵測器2〇包括加速度 係定位在接近肺快速吸人有關的動作,因而該侧器 用者握持該裝^。& °假若㈣測11 2G亦已仙指示該使 相關於圖 iA-7…25、3〇、4〇0、500、600、7〇〇(如以上 侧器20記錄ώ A.說明)的一電流存在,因而該 1存!中β亥偵刿器2 0將定位在該使用者身體上容許最有效 夂^肺。卩動作的一位置處。該肺部動作可用以確定該使 用者1〇已吞°燕藉由之前所說明的該醫藥輸送裝置輸送的處 方劑量。 視特定應用的需要而定,藉由該偵測器20所偵測的電 /;,L可為—般的’以致其僅識別該裝置3、25、30、400、500、 600、700(如以上相關於圖 1A-7C及圖12A-15B說明)已接 ,目&處所’其係為該使用者之口及四肢。於該等例子中, 每一裝置3、25、3〇、400、5〇〇、600、700能夠將該電流 流動+唯一的資訊編碼,特別是假若該使用者使用複數裝S 58 201208643 °Hai materials are deposited by physical steaming. The thickness of the material can be increased from about 5 to about 100 microns thick from about = or electroless deposition. By reducing the cover, about 500 microns, such as from , the shape. In addition, ie, each system may contain two or more electrical "for > children's readings" in which the material may be deposited. The upper-only region, if necessary, may be eliminated: On the opposite side, for example, the deposition of the other side of the side may be limited to the side selected for the same side as the one selected, and the term "not one." The n first selects (9) different sides of the inclined side to change the liquid, such as when the body fluid contacts, the material of interest:: but not limited to::= adhere the material to The frame of the donor layer contributes to the typical adhesion of the layer of a 钭, 仏忒 (special) material: 乂, ,, or each similar material. By physical vapor deposition, "hoarding method or electrodeposition deposition method for depositing anode material and the adhesive layer. The thickness of the (ano) material may be from about 0_05 to about 5 〇〇 microns, such as thickness from spoon 5 to about 1 〇〇 micron. However, the thickness or deposition process is not limited to the point of view of the I system or any of the materials used to deposit or fix the material to the frame. 59 201208643 According to the ~ point of view, any pair of such The material may be a material having different electrochemical potentials, such as 1 or different materials, wherein the 1EM system is determined to be in the organism, and the different materials may be vitamins that can be absorbed. Any two materials. The environment in which the 1EM system operates is different. When the material is used for ingestible food, the material of the pair is "language" ~ there is Μ electric scale electricity (4) any liquid, such as gastric acid, contact Γ when the 1 ΕΜ system is associated with an ion, and is specific The specific suitable material is not limited to gold non-metal selection, such as (four) towel, the pair is made up of a pair of metal and or (d): gold ^ (such as town) and a salt (such as cuC1 for the substance - - Metal salt materials are suitable for different chemical potentials (electric Fort) and low interfacial resistance. Suitable for different viewpoints, in Figures 1Α, 3Α, 5Α 12 Α ΐ Β Β ^ 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 的 的 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关A unit state controller, processing unit, processor, state machine communication shown in the description of the figures. The transconductance unit includes at least two contact regions electrically isolated from each other and positioned to allow Contact each contact area, and a power source. The at least one contact area Electrically coupling with one terminal of the power source and at least another contact region is electrically coupled to the other terminal of the power source. A current path is completed by the user's body, allowing the user and the two contact regions to The current flows when each contact, and the current is detected by the controller. 201208643 In one aspect, the transconductance unit further includes a control module coupled to the power source and the at least two contact regions One is electrically connected. The control module is configured to encode the information in the current flow. In one aspect, the devices 3, 25, 30, 400, 5〇〇, 6〇〇, 7 〇〇 (as described above in relation to Figures iA-7C and Figures 12A-15B) can be configured to ensure that a medical dose is delivered to a user. The device includes at least two contact regions electrically isolated from each other, and the power source includes a first terminal and a second terminal, wherein at least one contact region is electrically coupled to the first terminal and at least another contact region is coupled to the The second terminal is electrically coupled and a control module is electrically coupled between the first terminal of the power source and one of the contact regions. The control module is configured to change the conductivity of a current path generated by the user upon contact with the parent of the two contact regions. A current path is completed via the user's body when the user is in contact with each of the contact areas. This change in conductivity encodes the information in the current flow. The detectors of interest include, but are not limited to, the disclosure of PCT Application No. PCT/US2006/016370, the disclosure of which is WO 2006/116718, the disclosure of the patent application number PCT/2007/24225, which is incorporated herein by reference. The PCT application serial number PCT/US2 〇〇 8/52845, the disclosure of which is hereby incorporated by reference in its entirety in its entirety in the the the the the the the the the the the the ― According to other points of this (4), the pure may include two or more (such as three or more, including four or more cap detectors. In these systems, the two or more _11 may be suitably Arranged at any desired location on the user's body. For example, 'all body-integrated implements can be placed on the same side of the body on the 61 201208643 body, on the opposite side of the body, two:: the other torso, Or it may be configured to wait for the front and back of the specific instance towel h °. The sound unit 33 or::, from the lungs or in Figure 4C, the information system g early 31 receives the sound information, In the trunk week®, the most relevant 'so that the (four) detector system is equipped with a lion, _ 7: near the lung. In other points, with a position of (10)^, 2G can be configured on the user's body according to the User: Swallowing. Counting 90, inspecting the numbness! Another point of view, wherein the detector 2 includes an acceleration mechanism positioned to move close to the lungs to quickly attract people, so the side user holds the device ^ & ° If (4) measured 11 2G has also been indicated to be related to Figure iA-7...25, 3〇 , 4 〇 0, 500, 600, 7 〇〇 (such as the above side device 20 records ώ A. Description), a current exists, and thus the 1 memory! β 刿 detector 20 will be positioned on the user's body Allowing the most effective sputum to be at a location of the sputum action. The lung action can be used to determine the prescription dose that the user has swallowed by the medical delivery device previously described. However, the power detected by the detector 20 can be "typical" such that it only identifies the device 3, 25, 30, 400, 500, 600, 700 (as described above in relation to the figure) 1A-7C and Figures 12A-15B illustrate that the connected & the premises are the mouth and limbs of the user. In these examples, each device 3, 25, 3, 400, 5 , 600, 700 can flow the current + unique information encoding, especially if the user uses multiple devices
S 62 201208643 置,獨特地識別相對於所有其他裝置的特別裝置。 該裝置3、25、30、400、500、600、700(如以上相關 於圖1A-7C及圖12A-15B說明)係經構形複數之不同類型的 信號,包括但不限制在··經由控制傳導性所產生電流信號、 RF信號、磁性信號、傳導性(近場)信號、聲音信號等。該 傳輸時間可變化,其中於某些例子中該傳輸時間係位在自 0.1微秒至48小時或更長的範圍中,包括自1分鐘至10分 鐘。視該已知觀點而定,該識別器可產生一唯一的電流信 號一次。可任擇地,該識別器可經構形用以產生一唯一的 具相同資訊(相同信號)之電流信號,二或更多次,其中分離 的相同信號之收集可共同地視為一冗餘信號。 於某些觀點中,該偵測器與該裝置之該等組件及功能 塊係配置在積體電路上,其中該等積體電路包括複數之個 別的功能塊,亦即,模組及至少一些,例如二或更多,上 至包括所有的,功能塊可配置在一單一積體電路中。藉由 單一積體電路係意指包括所有的不同功能塊之一單一電路 結構。就其本身而論’該積體電路係為一早塊積體電路* 其係為一微型化電子電路(其可包括半導體裝置,以及被動 元件),已被構成在一半導體材料之薄基板的表面上。本發 明之某些觀點的該等積體電路可為混合的積體電路,其係 由個別半導體元件以及黏合至一基板或電路板所建構而成 的微型化電子電路。 儘管該前述發明已針對清晰地瞭解的目的經由圖解說 明及實例較為詳細地加以說明,但以下係以更為一般的形 63 201208643 式針對本發明之附加 提供-系統用以輪送二說明。因此,於-觀點二, 之輸送。該线包含使用者確 農置輕合。«置⑽^;1其經組構讀該使用者及一 I s& 枯外设其界定一腔室用以儲存該劑 域其係配置在該外殼上,並且該至少二 包衽::厂:互電隔離’以及-電源其係固定至該外殼並 : 端與—負相終端,其中至卜接點區域係與 ==端_合’以及至少另_接觸區域係與該負極終 =輕於—觀點中’該等接點區域可至少部分地在該 去二部分上露出。當使用者與該二接點區域之每一 日’ 由讀用者身體絲__電流路徑,以及藉由 、該使用者連接的該勤以仙電流流動。 4於冑點中’ 5亥裝置進一步包含一控制模組,其係在 亥電源與4至)_接點區域之其中之—者之間電連接,1 中該控制^組係經組構吨制自職置輸出的f訊。- 於-觀點中,該控制模組係經組構以改變該電流路徑 之傳導性’將該電流流動中的資訊編碼以及該仙 資訊解碼。 、於-觀點中,該裝置進—步包含一記憶體單元其係電 連接至雜制模組,帛叫存與輸關量至較用者有關 的資訊。 於-觀點中’該裝置進一步包含一收發器其係電耦合 至該控制模組,其中該資訊除了經由該電流流動外可自該 装置傳輸及/或接收至該偵測器。S 62 201208643, uniquely identifies a particular device relative to all other devices. The device 3, 25, 30, 400, 500, 600, 700 (as described above in relation to Figures 1A-7C and Figures 12A-15B) is configured to complexly different types of signals, including but not limited to Controls current signals generated by conductivity, RF signals, magnetic signals, conductive (near-field) signals, sound signals, and the like. The transmission time can vary, with the transmission time in some examples ranging from 0.1 microseconds to 48 hours or longer, including from 1 minute to 10 minutes. Depending on the known point of view, the identifier can generate a unique current signal once. Optionally, the identifier can be configured to generate a unique current signal having the same information (same signal), two or more times, wherein the collection of separate identical signals can be collectively considered a redundancy signal. In some aspects, the detector and the components and functional blocks of the device are disposed on an integrated circuit, wherein the integrated circuits include a plurality of individual functional blocks, that is, modules and at least some For example, two or more, up to and including all, the functional blocks can be configured in a single integrated circuit. By a single integrated circuit is meant to include a single circuit structure of all of the different functional blocks. As such, 'the integrated circuit is an early block integrated circuit* which is a miniaturized electronic circuit (which may include a semiconductor device, and a passive component) that has been formed on the surface of a thin substrate of a semiconductor material. on. The integrated circuits of some aspects of the present invention may be hybrid integrated circuits that are individual semiconductor components and miniaturized electronic circuits that are bonded to a substrate or circuit board. Although the foregoing invention has been described in greater detail by way of illustration and example for the purpose of clarity of understanding, the following description of the present invention in the form of a more general form. Therefore, in the - view two, the delivery. This line contains the user's light weight. «置(10)^;1 is configured to read the user and an I s & peripheral device defining a chamber for storing the agent domain, the system is disposed on the housing, and the at least two packs:: :electrical isolation 'and-power supply is fixed to the outer casing and: end and - negative phase terminal, wherein the contact zone is connected with == end_close' and at least another contact zone is associated with the negative terminal In the view, the contact regions may be exposed at least partially on the two portions. When the user and the two-contact area are in each day, the current path is flown by the reader's body wire, and the device connected by the user flows. 4 In the point of view, the '5 hai device further includes a control module, which is electrically connected between the Hai power source and the 4 to _ contact area, and the control unit is 1 ton. The self-produced output of the news. - In the view, the control module is configured to change the conductivity of the current path to encode the information in the current flow and decode the information. In the view, the device further includes a memory unit electrically connected to the hybrid module, and the information related to the user is stored and exchanged. The device further includes a transceiver electrically coupled to the control module, wherein the information is transmitted from the device and/or received to the detector in addition to the current flow.
S 64 201208643 内。於觀點中’該偵測器係經組構為植入在使用者身體 為偵測器包含一密封的外殼、一電源其係固定在該外 以及 i处為其係與該電源電耦合並固定在該外殼内, 少 ^ —感應探針其係固定至該外殼,其中該探針係至 :刀地暴露用以接觸該使用者組織。該探針係與該處理 益寬輕人,ra 參教、D ’ u此該處理器偵測與該使用者相關聯的生理學 i理t及通過該使用者的電流流動。一記憶體單元係與該 與讀二合並固定在該外殼内以儲存資料。該收發器係 二处理盗電轉合並固定在該外殼内用以自該裝置接收 ♦貧訊並將資訊解碼。 皮膚於▲觀點中’該偵測器係經組構以固定至該使用者的 ί偵測器包含—外殼、—電源其係岐至該外殼、 二其係與該電源電耦合並固定至該外殼、至少 仙定至該歧其帽騎餘”分地露出= 以=者皮膚,其中該探針係與該處理器電轉合,用 通過2處理11制與該使时相關_生理學參數以及 =该使用者的電流流動, 訊並將資訊解碼外如以自該裝置接收傳輸的資 於—觀點中,該收笋哭媳讲 ,偵測器包括-加速啟動信號至該_器以 至讀外殼。該加速度以f糸電輕合至該處理器並固定 器,收源自於該,置:該二該偵測 65 201208643 於一觀點中,該收發器包括一光學通訊裝置將一光束 中的資訊編碼,以及其中該偵測器包括一光學接收器其係 與該處理器電耦合並固定至該外殼。該光學接收器捕捉該 光束並將該資訊解碼。 於一觀點中,該收發器提供由該偵測器至一資料管理 中心的無線通訊。 於一觀點中,該收發器對該偵測器提供一啟動信號, 並且該偵測器進一步包含一聲音模組,其係電連接至該處 理器並固定至該外殼。該聲音模組係藉由該處理器啟動用 以在該偵測器自該裝置接收該啟動信號時偵測源自於該使 用者肺部的聲音資訊。 於一觀點中,提供一裝置用以輸送一醫藥劑量至一使 用者並追蹤輸送該劑量的時序。該裝置包含一外殼其界定 一腔室用以儲存該劑量,至少二接點區域其係配置在該外 殼的外部分上,其中該等接點區域係經組構以與該使用者 接觸並且其中該等接點區域係相互電隔離,以及一電源其 係固定至該外殼用以提供電力產生通過該使用者身體的一 電流流動,其中該電源包括二終端並且每一終端係電耦合 至一接點區域。當使用者皮膚與該至少二接點區域之每一 者接觸時,完成該電路,用以產生一電路致使電流流動通 過該使用者身體。 於一觀點中,該裝置進一步包含一控制模組其固定至 該外殼並與該二接點區域之每一者電耦合。該控制模組改 變介於該二終端之間該電流路徑之傳導性,用以變化通過S 64 201208643. In the view, the detector is configured to be implanted in the user's body, and the detector includes a sealed outer casing, a power source is fixed at the outer portion, and the system is electrically coupled and fixed to the power source. Within the housing, the sensing probe is secured to the housing, wherein the probe is attached to the blade to contact the user tissue. The probe is associated with the process, and the processor detects the physiology associated with the user and the current flow through the user. A memory unit is integrated with the read unit and secured within the housing to store data. The transceiver is adapted to handle theft and is fixed in the housing for receiving **** from the device and decoding the information. The skin is in the ▲ view that the detector is configured to be fixed to the user's detector comprising a housing, a power source that is electrically coupled to the housing, and two of the systems electrically coupled to the power source and secured thereto. The outer casing, at least the singularity of the cap, is exposed to the skin of the person, wherein the probe is electrically coupled to the processor, and is processed by the process 2 to correlate with the chronological _ physiological parameters and = the user's current flows, and the information is decoded, such as receiving the transmission from the device. In view of the fact, the sinker is crying, the detector includes - accelerating the start signal to the _to the read shell The acceleration is lightly coupled to the processor and the fixture, and the source is derived from the set. The second detection is 65 201208643. In one aspect, the transceiver includes an optical communication device in a light beam. Information encoding, and wherein the detector includes an optical receiver electrically coupled to the processor and secured to the housing. The optical receiver captures the beam and decodes the information. In one aspect, the transceiver provides From the detector to a data management Wireless communication of the heart. In one aspect, the transceiver provides an activation signal to the detector, and the detector further includes a sound module electrically coupled to the processor and secured to the housing. The sound module is activated by the processor to detect sound information originating from the lungs of the user when the detector receives the activation signal from the device. In one aspect, a device is provided for transporting a medical dose to a user and tracking the timing of delivering the dose. The device includes a housing defining a chamber for storing the dose, and at least two contact regions are disposed on an outer portion of the housing, wherein Contact regions are configured to contact the user and wherein the contact regions are electrically isolated from each other, and a power source is secured to the housing for providing electrical power to generate a current flow through the user's body, wherein The power supply includes two terminals and each terminal is electrically coupled to a contact area. When the user's skin contacts each of the at least two contact areas, the circuit is completed to generate The circuit causes current to flow through the body of the user. In one aspect, the apparatus further includes a control module secured to the housing and electrically coupled to each of the two contact regions. The conductivity of the current path between the two terminals for changing
S 66 201208643 該使用者的電流流動特性從而將該電流流動中的資訊編 碼。 於一觀點中,該裝置進一步包含一記憶體模組其係電 耦合至該控制模組並固定至該外殼。該記憶體模組儲存與 完成通過該使用者身體的電路以及劑量之輸送相關聯的資 訊。 於一觀點中,該裝置進一步包含一收發器其係電耦合 至該控制模組並固定至該外殼。該收發器單元容許該裝置 傳輸及/或接收與輸送劑量至該使用者相關聯的資訊。 於械點中,該收發器包括一光學傳送器模組供光學 通訊所用。 於一觀點中,該收發器包括一無線傳送器模組供1線 通訊所用。 於一觀點中,該收發器將源自於該記憶體單元的資訊 編碼並傳輸該資訊至位在該裝置外部的一系統。 於一觀點中,在完成通過該使用者身體的—電路時, 5亥收發态傳送—啟動信號至該外部系統,其中該啟動信號 係為°亥使用者握持該裝置並準備用以開始輸送該劑量的一 指示器。 —於一觀點中,提供一方法用於記錄一使用者服用一醫 藥;=)1里的時間。該方法包含當該使用者與該骏置之外部接 觸夺啟動裝置—電力模組,以該一方式完成—電路,考量 力板組之二終端間電流流動以及通過該使用者身 體,經由改變使用一傳導性控制模組而構成通過使用者身 67 201208643 T的該電路之傳導性而變化該等電流特性,使用一偵測器 4 /則通過4使用者身體的該等電流特性,該等電流特性包 括與該裝置及劑量之至少之一者相關聯的資訊,以及記錄 该可吸入劑量之輸送時間的步驟。 於一觀點令,提供一裝置用以輸送一醫藥劑量至一使 用者並確認該劑量之輸送。難置包含—外 室用㈣存該鮮,—轉其係㈣至料魅包括一正 =端與-負相終端’—控制模組其係與該電源電柄合, :聲音偵㈣其_定至該外殼並與該控組電搞合, ft該聲音制11偵測振動,以及至少二接點區域定位在 μ夕成上其巾该等接點區域係至少部分地在該外殼之外在 部分上露出以及該至少二接點區域係相互電隔離。該至少 一接點區域係與該電源之一終端電輕合,以及至少另一接 點區域係該另-終端電輕合。當使用者與該二接點區域之 Γ一者接觸時’經由該使用者身體完成一電流路徑,以及 糟由該控制模組偵測電流流動。 於一觀點中,該控制模組係於該電源與至少二接點區 =其中之—者之間電連接。該控制模組係經組構以控制 導性,將該電流流動中的資訊編石馬。 於一觀點中,該控制模組係與至少二接點區域以及該 電源之二終端電耦合。 於一觀點中,該聲音偵測器係固定至該外殼之外側。 於一觀點中,該裝置進一步包含一記憶體單元其係電 、接至該控制模組用以儲存與輪送劑量至該使用者有關連S 66 201208643 The user's current flow characteristics thereby encode the information in the current flow. In one aspect, the apparatus further includes a memory module electrically coupled to the control module and secured to the housing. The memory module stores information associated with completing the circuitry through the user's body and the delivery of the dose. In one aspect, the apparatus further includes a transceiver electrically coupled to the control module and secured to the housing. The transceiver unit allows the device to transmit and/or receive information associated with delivering the dose to the user. In the mechanical point, the transceiver includes an optical transmitter module for optical communication. In one aspect, the transceiver includes a wireless transmitter module for use in 1-wire communication. In one aspect, the transceiver encodes information from the memory unit and transmits the information to a system external to the device. In one aspect, when the circuit passing through the user's body is completed, the 5H transmit and receive signals are sent to the external system, wherein the activation signal is that the user holds the device and is ready to start transporting. An indicator of the dose. - In one aspect, a method is provided for recording a time when a user takes a medical drug; =) 1 . The method includes: when the user contacts the external device of the device, the power-on module, the power module is completed in the manner of the circuit, and the current flows between the terminals of the power board group and through the body of the user, A conductive control module constituting the current characteristics of the circuit through the user's body 67 201208643 T, using a detector 4 / then passing the current characteristics of the body of the 4 user, the current The characteristics include information associated with at least one of the device and the dose, and a step of recording the delivery time of the inhalable dose. In one aspect, a device is provided for delivering a medical dose to a user and confirming delivery of the dose. Difficult to contain - the outer room (four) save the fresh, - turn the system (four) to the material charm including a positive = end and - negative phase terminal '- control module and its power supply electric handle, : sound detection (four) its _ Positioning to the housing and engaging with the control unit, the sound system 11 detects vibration, and at least two contact areas are positioned on the surface of the contact area, the contact areas are at least partially outside the outer casing The portion is exposed and the at least two contact regions are electrically isolated from each other. The at least one contact area is electrically coupled to one of the terminals of the power source, and the at least one other contact area is electrically coupled to the other terminal. When the user comes into contact with the other of the two contact areas, a current path is completed through the user's body, and the current is detected by the control module. In one aspect, the control module is electrically coupled between the power source and at least two contact regions = one of them. The control module is configured to control the conductance, and the information in the current flow is programmed. In one aspect, the control module is electrically coupled to at least two contact regions and two terminals of the power source. In one aspect, the sound detector is attached to the outside of the housing. In one aspect, the device further includes a memory unit electrically coupled to the control module for storing and transferring the dose to the user
S 68 201208643 的資訊。 於一觀點中,該裝置進—弗 至該控制模組,其中該資訊^包卜收發器其係電麵合 該裝置傳輸及/或接收至—外^^由1 ㈣流流動外能夠由 於一觀點中,該聲音偵測哭 於-觀財,在峨表 振,該==說的一 於一硯財,該聲音偵測器提供 模組’並且該控制模組 。號遠控制 資1。兮次#〆 亥使用者吸入相關聯的聲音 、°二 由該聲音_器提供至該控制模粗。 的一唯㈣模組提供與該劑量之輸送有關聯 H 及其中該控制模組接收-識別器信 ;ί二、二:使用者相關聯,其中該時間戳記與該識別器作 儿之、,、口 5確認該劑量輸送至該使用者。 於二-觀,中’提供一裝置用以輸送一劑量至一使用者 、’t蹤忒剤里之輸送的時序。該裝置包含一外殼其界一 ί至儲ΐ該劑量,至少二接點區域其係配置在該外殼 部亥寺接點區域係至少部分地暴露在該外殼之該外 :,以及至少二接點區域係相互電隔離,一電源並 用以提供電力產生通過該使用者身體的- 控制:=,:制模组其係電柄合至該電源,其甲該 及一声眠模式而該裝1係處於不作動狀態,以 耳曰;$其ϋ定至料殼並與該控侧組電叙合, 69 201208643 其中該聲音偵測器偵測振動並輸送一啟動信號至該控制模 組用以啟動該控制模組。裝填進入該腔室的該劑量之一聲 音啟動該控制模組,並且其中當該使用者與每一接點區域 接觸時’經由該使用者身體完成—電流路徑,指示該使用 者將接收該醫藥的一劑量。 於-觀點中,該裝置進—步包含—記憶體單元其電轉 合至該控龍組並岐至料殼。誠憶體模_存 送該劑量至該使用者相關聯的資訊。 规點r吻衣罝退一芡包含一傳送器單元其係電 搞合至該控制模組並岐至該外殼。該傳送 ς件 許該裝置傳送資訊。 谷斤谷 於一覜點中 咏衣直退一步包含一光學偵測器模組用 量係輸送至較用者,以及㈣光學資訊與和 ^ 裝置吸入所產生的該聲音振動相關聯的聲音資訊比 較,用以確認該劑量輸送至該使用者。 ::觀‘財,提供一系統用以輸送一醫藥劑量至一使 =並確認該劑量之輸送。該系統包含—制器其包括一 - 器,其中該摘測器係由該使用者所配戴,以及 2置其,含—外殼其界定—腔室用以儲存該劑量,一電 固疋至該外殼並包括一正極終端與一負相终端,苴 t该電源包括一隔離源其產生一戴波, : 其—組改變該隔離源之二 八 £忒係為一邛为地暴露的接點區域以及 201208643 一區域係為電容性耦合區域,其中該二區域係相互電隔離 的。該隔離源之一輸出係與該接點區域耦合以及該隔離源 之另一輸出係耦合至該電容性耦合區域。該接點區域係由 該使用者碰觸以及該電容性耦合區域係電容地耦合至由該 使用者配戴的該電容性耦合器。該載波路徑的一部分係使 用該接點區域通過該使用者身體,以及該載波路徑的一部 分係使用介於該電容性耦合區域與由該使用者配戴的該電 容性耦合器之間的電容性耦合而通過電容性傳導。於此說 明針對偵測器的相同原理亦可應用在配置在該醫藥輸送裝 置上的一致動器。 於一觀點中,該外殼界定一孔口用以當該使用者經由 該裝置吸入時產生一聲波,並且其中該偵測器進一步包含 一聲音偵測器用於偵測與該使用者經由該裝置吸入有關聯 的聲波,行經該使用者身體及空氣的聲波,其中該聲音偵 測器使通過該使用者身體的聲波與通過空氣的聲波相關 聯,用以確認該劑量輸送至該使用者。 於一觀點中,提供一系統用以輸送一醫藥劑量至一使 用者並確認該劑量之輸送。該系統包含與該使用者連接的 一偵測器,其中該偵測器收集與該使用者有關的生理學資 訊,用以產生與該使用者有關的個人簡介,一裝置,其中 該裝置包括一外殼其界定一腔室用以儲存該劑量以及一開 口,該使用者經由該開口吸入用以接收該劑量以及一聲音 單元用於產生一聲音信號。該聲音單元係固定至該裝置之 該外殼。該聲音單元包含一支樓層其在一表面上包含一黏 71 201208643 著層用於將該聲音單元固定至該裝置,—振動偵測單元其 係固定至該支撐層則貞測藉由該裝置以及該使用者經由該 裝置吸入所產生的聲音資訊並產生—_信號,一控制器 其係固^至該支撐層並與該振動彳貞測單元軌,其中該控 制器接收源自於該振動㈣單元的_信魅產生代表該 债測信號的-數位信號,—聲音產生單元其仙定至該支 禮層並與難制ϋ軌,其巾該聲音產生單元接收該數位 L遽並產生@聲音信號,以及__頂部層其仙定至該支樓 曰乂界疋腔至其包含並保護該振動單元、該控制5|以及 該㈣内的聲音產生單元。該聲音信號代表與裝填進入該 腔f的該可吸人劑量以及該使用者經由該裝置吸入相關聯 的貧訊,並且其中該聲音信號係藉由該偵測器加以偵測以 確認該劑量之輪送。 —於二觀點中,該系統進一步包含至少二接點區域其係 疋位外喊上。該等接點區域至少部分地暴露在該外殼 _卜P刀上以及δ亥至少二接點區域係相互電隔離。該聲音 匕括電源。该至少一接點區域係與該電源之一正極 :端,耦合,以及至少另一接點區域係與該負極終端電耦 田使用者與該二接點區域之每一者接觸時,經由該使 者身體完成-電流路徑’以及藉由與該使用者連接的該 偵測器偵測電流流動。 於一觀點中,該控制器係經組構以控制源自於該聲音 早元的資訊輪出。 於觀點中,該控制器係經組構以改變該電流路徑之S 68 201208643 information. In one aspect, the device is rushed to the control module, wherein the information is transmitted to the transceiver, and the device is transmitted and/or received to the outside of the device. In the point of view, the sound detection is crying----------------------------------------------------------------------------------------------- The sound detector provides a module 'and the control module. No. Yuan Control Capital 1.兮次#〆 Hai user inhales the associated sound, °2 is supplied by the sound _ to the control mode. a (4) module is provided in association with the delivery of the dose and the control module receives the - recognizer letter; 二 2, 2: the user is associated, wherein the time stamp is associated with the identifier, Port 5 confirms that the dose is delivered to the user. In the second to the middle, a device is provided for delivering a dose to a user, the timing of the delivery in the 't. The device includes a housing that is bounded to the dose, and at least two contact regions are disposed at the portion of the housing portion that is at least partially exposed to the outer portion of the housing: and at least two contacts The zones are electrically isolated from each other, and a power source is used to provide power through the body of the user - control: =,: the module is connected to the power source, and the device is in a sleep mode and the device is in the system In the unactuated state, the deafness is set; the ϋ is determined to the casing and is electrically combined with the control side, 69 201208643 wherein the sound detector detects the vibration and sends a start signal to the control module to activate the Control module. One of the doses loaded into the chamber activates the control module, and wherein when the user is in contact with each of the contact areas, 'through the user's body completes a current path indicating that the user will receive the medicine a dose. In the view, the device further includes - the memory unit is electrically coupled to the control group and is transferred to the shell. Recall the phantom_save the dose to the information associated with the user. The ruler is a retractor that includes a transmitter unit that is coupled to the control module and to the housing. The transfer component allows the device to transmit information. In the first step, Gujin Valley takes a step back and forth, including an optical detector module to deliver to the user, and (4) optical information and sound information associated with the sound vibration generated by the device suction. To confirm that the dose is delivered to the user. :: Viewing, providing a system for delivering a dose of medicine to a = and confirming the delivery of the dose. The system includes a controller, wherein the extractor is worn by the user, and the second device is provided with a housing defining a chamber for storing the dose, The housing includes a positive terminal and a negative phase terminal, and the power supply includes an isolation source to generate a wave, wherein: the group changes the isolation source to a contact point The area and the 201208643 area are capacitive coupling areas, wherein the two areas are electrically isolated from each other. An output of the isolation source is coupled to the contact region and another output of the isolation source is coupled to the capacitive coupling region. The contact area is touched by the user and the capacitive coupling region is capacitively coupled to the capacitive coupler worn by the user. A portion of the carrier path passes through the user's body using the contact area, and a portion of the carrier path uses capacitive between the capacitive coupling region and the capacitive coupler worn by the user. Coupling is conducted by capacitive conduction. It is noted herein that the same principles for the detector can also be applied to the actuators disposed on the medical delivery device. In one aspect, the housing defines an aperture for generating an acoustic wave when the user is inhaled through the device, and wherein the detector further includes a sound detector for detecting and inhaling the user via the device An associated sound wave travels through the body and air of the user, wherein the sound detector correlates sound waves passing through the user's body with sound waves passing through the air to confirm delivery of the dose to the user. In one aspect, a system is provided for delivering a pharmaceutical dose to a user and confirming delivery of the dose. The system includes a detector coupled to the user, wherein the detector collects physiological information related to the user for generating a profile related to the user, a device, wherein the device includes a The housing defines a chamber for storing the dose and an opening through which the user inhales to receive the dose and a sound unit for generating an acoustic signal. The sound unit is secured to the housing of the device. The sound unit comprises a floor which comprises a glue on a surface. 71 201208643 layer is used for fixing the sound unit to the device, and the vibration detecting unit is fixed to the support layer by means of the device and the The user inhales the generated sound information through the device and generates a signal, a controller fastens to the support layer and the vibration detecting unit rail, wherein the controller receives the vibration (four) unit The _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ And the __ top layer is destined to the branch of the branch to the sound unit, the control unit 5| and the sound generating unit in the (4). The sound signal represents the absorbing dose associated with loading into the cavity f and the user is associated with the inhalation via the device, and wherein the sound signal is detected by the detector to confirm the dose. Round. - In the second aspect, the system further includes at least two contact areas that are shouted out of the system. The contact regions are at least partially exposed to the outer casing and the at least two contact regions are electrically isolated from each other. This sound includes the power supply. The at least one contact region is coupled to one of the positive terminals of the power source, and the at least one other contact region is contacted by the user of the negative terminal terminal and the contact region. The messenger body completes the current path' and detects the current flow by the detector connected to the user. In one aspect, the controller is configured to control the information rotation from the sound early element. In the view, the controller is configured to change the current path
S 72 201208643 傳導性’將該電流流動中的貧訊編碼。 於一觀點中,該聲音單元進一步包含一記憶體單元其 係與該控制器電連接用於儲存。 於一觀點中,該偵測器係經組構為植入在使用者身體 内。該偵測器包含一密封的外殼、一電源其係固定在該外 殼内、至少一感應探針其係固定至該外殼,其中該探針係 至少部分地暴露用以接觸該使用者組織,其中該探針係與 該處理器電耦合,因此該處理器偵測與該使用者相關聯的 生理學參數以及通過該使用者的電流流動,一收發器模組 其係電耦合至該處理器並固定在該外殼内以接收源自於該 裝置傳送之資訊並解碼,以及一記憶體單元係與該處理器 電耦合並固定在該外殼内以儲存資料。 於一觀點中,該偵測器係經組構以固定至該使用者的 皮膚。該偵測器包含一外殼、一電源其係固定至該外殼、 一處理器其係與該電源電耦合並固定至該外殼、至少一感 應探針其係固定至該外殼,其中該探針係與該處理器電耦 合,用以容許該處理器偵測與該使用者相關聯的生理學參 數以及通過該使用者的電流流動,一傳送器模組其係與該 處理器電耦合並固定至該外殼以接收源自於該裝置傳送之 資訊並解碼,以及一記憶體單元係與該處理器電耦合並固 定在該外殼内以儲存資料。 於一觀點中,該系統進一步包含一裝置其係固定至該 裝置之外殼。該裝置提供一啟動信號至該偵測器以及該偵 測器包括一加速度計其係電耦合至該處理器並固定至該偵 73 201208643 測器之外殼。該加速度計係藉由該偵測器之處理器啟動用 以在忒偵測器接收源自於該裝置的該啟動信號時偵測動 作。 於镜點中,收發益模組提供由該偵測器至一資料管 理中心的該資料之無線通訊。 於一觀點中,提供一裝置用以偵測輸送可吸入醫藥至 一使用者。該裝置包含一振動偵測單元用以偵測聲音資訊 並產生一偵測信號,一控制器與該振動偵測單元通訊,其 中該控制器接收源自於該振動偵測單元的偵測信號並產生 代表該偵測信號的一數位信號,一聲音產生單元其係固定 至該支撐層並與該控制器通訊,其中該聲音產生單元接收 該數位信號並產生一聲音信號,指示該可吸入劑量之輸送。 於觀點中,s亥裝置進一步包含一傳輸單元與該控制 器通訊。該傳輸單元接收該數位信號並與一無線裝置 用以指示已發生該吸入事件。 於一觀點中,該裝置進一步包含一跨導單元與該控制 器通訊。該跨導單元包含相互電隔離的至少二接點區域, 並經定位用以容許與每一接點區域接觸,以及一電源。該 至少一接點區域係與該電源之一終端電麵合以及至少另一 接點區域係與該電源之另一終端電耦合。通過該使用者的 身體7L成一電流路徑,容許當該使用者與該二接點區域之 每一者接觸時電流流動,並藉由該控制器偵測電流流動。 於一觀點中,於一觀點中,該跨導單元進一步包含一 控制模組其係於该電源與該至少二接點區域之其中之一者 201208643 門電連接5亥控制模組係經組構以將該該電流流動中的資 訊編瑪。 於一觀點中’提供一裝置用以確認輸送一醫藥劑量至 “使用者。該裝置包含至少二相互電隔離的接點區域,一 電源括一第一終端及第二終端,其中至少一接點區域 第終端電耦合以及至少另一接點區域係與該第二 終端书耦合,以及一控制模組在該電源之該第一終端與其 广之-接點區域之間電連接。該控制模組係經組構以改變 二使用者經與该二接點區域之每一者接觸即產生的—電 1授之傳導性。當該使用者能二接點區域之每一者接 觸時經由該使用叙身體完成一電流路徑 。該傳導性之變 化將該電流流動中的資訊編碼。 +於-觀·點中,提供一方法用於記錄一使用者服用一醫 藥劑量的日㈣。該方法包含當該使用者與該裝置之外部接 觸時=動裝置—電力模組,以該—方式完成—電路,考量 到”亥%力杈組之二終端間電流流動以及通過該使用者身 f ’經由改變使用—料性㈣模組而構成通過使用者身 肢的該電路之傳導性而變化該等電流特性,施用—聲音單 =產生-聲音信號’使K貞測器制該聲音信號,其中 該聲音信號包括與輸送劑量至該使用者相關聯的資訊:、以 及记錄該可吸入劑量之輸送時間的步驟。 =特定顧而定,_可經以複數之不同的構 广對於所關注器官而定位。例如,其中使用一單體作號 伯測記相Μ的信㈣測器,料方法可包括初始定位或u 75 201208643 植入該單~ ,, 所關注C位在最接近所關注之器官之-位置處。 位在接近肺;Ϊ係為肺部,如為所需,該單-接收器可定 统,兮=處。利用包括二或更多信號偵測器的其料 方法可包㈣-2 置處。例如,該等 別位置i::或更多個別的偵測器定位在接近肺部的個 二摘測〜1疋將—偵測器定位在前腹部位置處以及一第 二二:立在:背部位置。此後者構形係代表該等债測器 :⑽兮―目標器官之相對側邊上的例+,例如,用以測量 通過该器官的阻抗、動作或是聲音。 應瞭解的是本發明並未限制在所說明的特定觀點,而 就其本身而論係可加以變化。亦應瞭解的是於此所使用的 專門用語係僅為了說明特定的觀點而不意欲具限制性,因 為本發明之Ιε8#將僅由料附加的巾料利範圍所限定。 所提供的一數值範圍中’應瞭解的是每一居中值,除 非於上下文中清楚地另有說明外否則係至該下限之單位的 十分位’介於該範圍的上與下限之間,以及於該陳述範園 中任何其他的陳述或居中值係包含於本發明中。該等軾小 範圍之該上限及下限可獨立地包括在該等較小範圍中旅亦 係包含於本發明中,受該所陳述範圍中任何具體排除的隊 制所規限。該陳述範圍包括該等限制之一或是二者,讲除 該等包括之限制的任—者或是二者的範圍亦包括於本發明 中。 除非另有定義,否則於此使用的所有技術及科學的用 5吾具有如熟知本發明所屬技藝之人士 一般瞭解之相同的总S 72 201208643 Conductivity 'Codes the poorness in the current flow. In one aspect, the sound unit further includes a memory unit electrically coupled to the controller for storage. In one aspect, the detector is configured to be implanted within the body of the user. The detector includes a sealed housing, a power source secured within the housing, and at least one sensing probe secured to the housing, wherein the probe is at least partially exposed for contacting the user tissue, wherein the detector is The probe is electrically coupled to the processor, such that the processor detects physiological parameters associated with the user and current flow through the user, a transceiver module electrically coupled to the processor and Fixed within the housing to receive information transmitted from the device and decoded, and a memory unit is electrically coupled to the processor and secured within the housing for storing data. In one aspect, the detector is configured to be secured to the skin of the user. The detector includes a housing, a power source secured to the housing, a processor electrically coupled to the power source and secured to the housing, and at least one sensing probe secured to the housing, wherein the probe system Electrically coupled to the processor for allowing the processor to detect physiological parameters associated with the user and current flow through the user, a transmitter module electrically coupled to the processor and secured to the processor The housing receives and decodes information transmitted from the device, and a memory unit is electrically coupled to the processor and secured within the housing for storing data. In one aspect, the system further includes a device that is secured to the housing of the device. The device provides a start signal to the detector and the detector includes an accelerometer electrically coupled to the processor and secured to the housing of the detector. The accelerometer is activated by the processor of the detector to detect an action when the 忒 detector receives the enable signal originating from the device. In the mirror point, the transceiver module provides wireless communication of the data from the detector to a data management center. In one aspect, a device is provided for detecting delivery of an inhalable medicament to a user. The device includes a vibration detecting unit for detecting sound information and generating a detecting signal, and a controller is in communication with the vibration detecting unit, wherein the controller receives the detecting signal originating from the vibration detecting unit and Generating a digital signal representative of the detection signal, a sound generating unit is fixed to the support layer and communicating with the controller, wherein the sound generating unit receives the digital signal and generates an acoustic signal indicating the inhalable dose delivery. In the opinion, the device further includes a transmission unit to communicate with the controller. The transmission unit receives the digital signal and is coupled to a wireless device to indicate that the inhalation event has occurred. In one aspect, the apparatus further includes a transconductance unit in communication with the controller. The transconductance unit includes at least two contact regions electrically isolated from each other and positioned to permit contact with each of the contact regions, and a power source. The at least one contact region is electrically coupled to one of the terminals of the power source and the at least one other contact region is electrically coupled to the other terminal of the power source. A current path is formed by the user's body 7L, allowing current to flow when the user is in contact with each of the two contact areas, and detecting current flow by the controller. In one aspect, the transconductance unit further includes a control module coupled to one of the power source and the at least two contact regions, the 201208643 gate is electrically connected to the 5H control module system. To compile the information in the current flow. In one aspect, 'providing a device for confirming delivery of a medical dose to a user. The device includes at least two contact regions electrically isolated from each other, and a power source includes a first terminal and a second terminal, wherein at least one of the contacts The area terminal electrical coupling and at least one other contact area are coupled to the second terminal book, and a control module is electrically connected between the first terminal of the power source and the wide-contact area thereof. The structure is configured to change the conductivity of the two users through contact with each of the two contact regions. When the user can contact each of the two contact regions via the use The body completes a current path. The change in conductivity encodes the information in the current flow. In the point of view, a method is provided for recording a day when a user takes a medical dose (4). When the user is in contact with the outside of the device, the mobile device-power module is completed in this manner, and the current flow between the two terminals of the "Hybrid" group and the user's body f' Using a material-like (four) module to form the current characteristics of the circuit through the user's limbs, the application-sound single = generate - sound signal causes the K detector to make the sound signal, wherein the sound The signal includes information associated with delivering the dose to the user: and a step of recording the delivery time of the inhalable dose. = Depending on the particulars, _ can be located for the organ of interest by a complex structure. For example, a letter (four) detector in which a single cell is used as a counter-measurement may be included, and the method may include initial positioning or implantation of the single-bit at the time of U 75 201208643, and the C-position of interest is closest to the organ of interest - Location. Located close to the lungs; the sputum is the lungs, and if required, the single-receiver can be ordered, 兮=where. The material method including two or more signal detectors can be used to package (4)-2. For example, the other locations i:: or more individual detectors are positioned in the vicinity of the lungs. The second detector is located at the front abdomen position and the second and second detectors are located at: Back position. The latter configuration represents the debt detectors: (10) 兮 - the instance + on the opposite side of the target organ, for example, to measure impedance, motion or sound through the organ. It should be understood that the present invention is not limited to the particular aspects described, but may be varied as such. It is also to be understood that the specific terminology used herein is for the purpose of illustration and description, and is not intended to be limiting, as the Ιε8# of the present invention will be limited only by the scope of the material to which the material is attached. In the range of values provided, 'should be understood to mean each of the median values, unless the context clearly indicates otherwise, the decile of the unit to the lower limit' is between the upper and lower limits of the range, and Any other statements or median values in this statement are included in the present invention. The above-mentioned upper and lower limits of such a small range may be independently included in the scope of the invention, and are included in the invention, and are subject to any specifically excluded team in the stated range. The scope of the statement includes one or both of the limitations, and the scope of the invention or the scope of the invention is also included in the invention. Unless otherwise defined, all technical and scientific uses used herein have the same general knowledge as commonly understood by those skilled in the art to which the invention pertains.
S 76 201208643 管與於此說明者相似或等同的任何方法及材料亦能 檢驗本發明時使用,但現說明的是代表性說明 方法及材料。 於此說明書中所引用的所有公開案及專利,於此 =本案以為參考㈣’如同每—烟公開 ==示:入作為參考資料,並係於此併入作為: 考貝枓用㈣讀說日讀該等公職所相之 等方法及/或材料。任何公開案之引用係針辦在申 其j揭示内容’並且不應視為承認本發明係未具;格藉: 先則發明將該公開案提前日期。再者,所提供的該公^ 之日期可與該需獨立地確認之實際的公開案日期不同。>、 應注意的是,如於此及該等附加的申請專利 使用者,除非於上下文中另有清楚地指示,否 形式”a”、’’an”、及’’the”包括複數的指示物。應進一步=音、 的是該等申請專利範圍可經擬寫成將任何可任擇=件^ 除。就其本身而論,此陳述係意欲使用作為與申請=利j 圍元件之詳述有關針對使用諸如,,唯一地(s〇lely)=、,,乾 (only) ”及相似者,或是使用,,負面,,表示的先行詞其礎。 於此所提出的特定範圍係於該用語,,大約(ab〇ut),, 前具有數值。於此使用的該用語”大約(about),,,針對其 之前的確切數字,以及接近或是大約為該用語之前的嗜妻欠 字的一數字提供字面上的支援。在確定一數字係接近^ a 大約為一具體詳述的數字當中,該接近或是近似未^述= 字,於提出的上下文中,可為一數字提供該具體詳述$數 77 201208643 字之實質等同。 熟知此技藝之人士一經閱讀此揭示内容將為顯而易見 的是與此說明及圖示的每一個別觀點具有各別的構成成分 與特性,其可與任何的其他複數觀點之該等特性容易地分 開或是與之結合而不致背離本發明之範疇及精神。任何詳 述的方法能夠在所詳述情況之順序,或是邏輯上可能的任 何其他順序下完成。 儘管該前述發明為了清楚地瞭解之目的已經由圖式及 實例稍微詳細地加以說明,但熟知此技藝之人士根據本發 明之講授内容將容易地顯而易見,可對本發明作改變及修 改而不至背離該等附加的申請專利範圍之精神或範疇。 【圖式簡單說明】 在該等附加的申請專利範圍中特別地提出本發明之該 等不同觀點的新穎特性。然而,該等不同的觀點,就組織 與作業的方法而言,於此係藉由實例結合以下該等圖式以 及相對應的敘述加以說明,其中整個相同的代表符號係與 相同的元件有關。 圖1A係為一使用者配戴一偵測器並與一裝置接觸的 一說明性實例,其係以一方塊圖的形式顯示,其中根據本 發明之指導輸送一吸入劑量。 圖1B係根據本發明之指導顯示針對圖1A之該裝置的 一可行的實體形狀。 圖1C係根據本發明之指導顯示針對圖1A之該裝置的S 76 201208643 Any methods and materials similar or equivalent to those described herein can also be used in the examination of the present invention, but are now illustrative of the methods and materials. All the publications and patents cited in this specification are hereby incorporated by reference. (4) 'As per-tobacco disclosure == indication: as a reference material, and hereby incorporated as: Kaobeiwei (4) Reading Read the methods and/or materials of such public offices on a daily basis. The citation of any publication is hereby disclosed and is not to be construed as an admission that the invention is not Furthermore, the date of the public offering may be different from the actual publication date to be independently confirmed. > It should be noted that the terms "a", "an", and "the" are plural, unless the context clearly indicates otherwise. Indicator. It should be further = sound, that the scope of such patent applications can be written to remove any optional = parts. For its part, this statement is intended to be used in connection with the application of the details of the application, such as, for example, only (s〇lely) =, ,, only and similar, or The use of, negative, and the antecedent of the expression. The specific scope set forth herein is the term, approximately (ab〇ut), preceded by a numerical value. The term "about" used herein is about , providing literal support for the exact number before it, and a number that is close to or about the word of the aboriginal word before the term. In determining that a number is close to a certain number, which is approximately a detailed description, the proximity or approximation is not a word, and in the context of the proposal, a specific detail may be provided for a number of $77 201208643 Substantially equivalent. It will be apparent to those skilled in the art that upon reading this disclosure, it is obvious that each individual point of the description and illustration has individual constituents and characteristics that can be easily separated from those of any other plural. It may be combined with it without departing from the scope and spirit of the invention. Any of the detailed methods can be performed in the order in which they are described, or in any other order that is logically possible. Although the foregoing invention has been described in some detail and the embodiments of the embodiments of the present invention, the invention may be The spirit or scope of these additional patentable scopes. BRIEF DESCRIPTION OF THE DRAWINGS The novel features of the various aspects of the present invention are specifically set forth in the scope of the appended claims. However, the various points of view, in terms of the method of organization and operation, are illustrated by the following examples in conjunction with the accompanying drawings and the corresponding description. Figure 1A is an illustrative example of a user wearing a detector and in contact with a device, shown in the form of a block diagram in which an inhalation dose is delivered in accordance with the teachings of the present invention. Figure 1B shows a possible physical shape for the device of Figure 1A in accordance with the teachings of the present invention. Figure 1C shows the device of Figure 1A in accordance with the teachings of Figure 1A.
S 78 201208643 一可行的實體形狀。 圖1D係根據本發明之指導顯示針對圖1A之該裝置的 一可行的實體形狀。 圖2A係為圖1A中所示方塊圖形式以及根據本發明之 指導之該裝置的一可任擇觀點。 圖2B係為圖1A中所示方塊圖形式以及根據本發明之 指導之該裝置的一可任擇觀點。 圖3A係為一使用者配戴一偵測器並與一裝置接觸的 一說明性實例,其係以方塊圖形式顯示,其中根據本發明 之指導輸送一吸入劑量。 圖3B顯示根據本發明之指導針對包含一聲音單元的 圖3A之該裝置的另一可行實體形狀。 圖3C顯示根據本發明之指導針對包含一聲音單元的 圖3A之該裝置的另一可行實體形狀。 圖3D顯示根據本發明之指導針對包含一聲音單元的 圖3A之該裝置的另一可行實體形狀。 圖3E係為一使用者配戴一偵測器並與一裝置接觸的 一說明性實例,其係以方塊圖形式顯示,其中根據本發明 之另一觀點輸送一吸入劑量。 圖3F係為圖3E之該裝置的一部分的一側視圖。 圖4A係為以方塊圖形式顯不並根據本發明之指導針 對包含一聲音單元的圖3A之該裝置的一可任擇觀點。 圖4B係為以方塊圖形式顯示並根據本發明之指導針 對包含一聲音單元的圖3A之該裝置的一可任擇觀點。 79 201208643 圖4C係為根據本發明之一觀點的一聲音單元的一俯 視圖。 圖4D係為根據本發明之一觀點的一聲音單元的一圖 式。 圖4E係為根據本發明之一觀點的一聲音單元的一圖 式。 圖5A係為一使用者配戴一偵測器並與一裝置接觸的 一說明性實例,其係根據本發明之指導以方塊圖形式顯示。 圖5B顯示根據本發明之指導針對具有一與接點區域 電連接之裝置的圖5A之該裝置的一可行實體形狀。 圖5C顯示根據本發明之指導針對具有一與接點區域 電耦合之裝置的圖5A之該裝置的一可行實體形狀。 圖5D顯示根據本發明之指導針對圖5A之該裝置的一 可行實體形狀,其具有一裝置及一聲音單元,分別與接點 區域電耦合。 圖5E顯示根據本發明之一觀點及指導的一聲音單元。 圖5F顯示根據本發明之另一觀點及指導的一聲音單 元。 圖6A係為以方塊圖形式顯示並根據本發明之指導的 一觀點的圖5B、5C及5D之該裝置。 圖6B係為以方塊圖形式顯示並根據本發明之指導的 另一觀點的圖5B、5C及5D之該裝置。 圖7A係為根據本發明之另一觀點的圖ΙΑ、3A及5A 之該裝置之該開口的一圖式,其中一膜片係配置在接近該 201208643 吸入劑量經配送通過的該裝置之該開口。 圖7B係為圖7A之該裝置的該膜片的 =⑽由該使用者吸入該劑量時分成幾=, 先束中斷並且偵測到該中斷。 刀乂致 膜片7 A之該裝置的該膜片的—圖式,其中該 等膜時分成幾部分’以致該 相片。P刀之—幫曲運動及分割導致一連接中的一中斷。 方塊^係為圖认、从、5八之該等偵測器的任一者之一 圖9係為圖8之一處理器的一方塊圖。 、圖㈣為根縣發明之指導的—使料配戴 以及當該使用者吸入時與一裝置〃 的-實例。 4置接觸用以接收-吸入劑量 出人裝置其具有記錄與維修保養該出入 裝置有關的某些事件之時序的能力。 圖12Α係為根據本發明之指導的—使 器並=裝置接觸的一說明性實例,其係以方塊^ 不,其輸送一醫藥劑量。 貝 顯示根據本發明之指導的圖以之該醫藥輸送 义置的H用於由—藥丸貯存器輸送—單獨的藥丸。 圖12C圖示根據本發明之指導的圖12八之用於由 丸貯存H輸送-單獨㈣丸之該輸職置的—觀點,、 圖灿圖示根據本發明之指導的圖12八之用於由—單 獨地密封的藥丸貯存器輸送—單獨的藥丸之該醫藥輸送裳 201208643 置的一觀點。 圖13A係為根據本發明之指導的一使用者配戴一偵測 器並與一裝置接觸的一說明性實例,其係以方塊圖形式顯 示,其輸送一醫藥劑量。 圖13B係圖示根據本發明之指導的圖13A之該醫藥輸 送裝置的一觀點,用於自於其中包含複數之密封藥丸的一 膠帶中輸送一單獨的藥丸。 圖13C係根據本發明之指導圖示該膠帶的一觀點,其 包含複數之密封於一包裝中的藥丸,能夠加以盤繞並插入 在圖13A之該裝置的一腔室中。 圖13D係根據本發明之指導圖示圖13A之該醫藥輸送 裝置的一觀點,用於自於其中包含複數之密封藥丸的一膠 帶中輸送一單獨的藥丸。 圖13E係為根據本發明之指導的一膠帶輸送機構的一 俯視圖,其用於圖13A之該醫藥輸送裝置之一觀點的液體 醫藥輸送。 圖13F係為根據本發明之指導的一膠帶輸送機構的一 側視圖,其用於圖13A之該醫藥輸送裝置之一觀點的液體 醫藥輸送。 圖14A係為根據本發明之指導的一使用者配戴一偵測 器並與一裝置接觸的一說明性實例,其係以方塊圖形式顯 示,其輸送一醫藥劑量。 圖14B係圖示根據本發明之指導的圖13A之該醫藥輸 送裝置的一觀點,用於自於其中包含複數之密封藥丸的一S 78 201208643 A viable solid shape. Figure 1D shows a possible physical shape for the device of Figure 1A in accordance with the teachings of the present invention. Figure 2A is an illustration of the block diagram shown in Figure 1A and the apparatus in accordance with the teachings of the present invention. Figure 2B is an illustration of the block diagram shown in Figure 1A and the apparatus in accordance with the teachings of the present invention. Figure 3A is an illustrative example of a user wearing a detector and in contact with a device, shown in block diagram form in which an inhalation dose is delivered in accordance with the teachings of the present invention. Figure 3B shows another possible physical shape for the device of Figure 3A containing a sound unit in accordance with the teachings of the present invention. Figure 3C shows another possible physical shape for the device of Figure 3A containing a sound unit in accordance with the teachings of the present invention. Figure 3D shows another possible physical shape for the device of Figure 3A containing a sound unit in accordance with the teachings of the present invention. Figure 3E is an illustrative example of a user wearing a detector and in contact with a device, shown in block diagram form, wherein an inhalation dose is delivered in accordance with another aspect of the present invention. Figure 3F is a side elevational view of a portion of the device of Figure 3E. Figure 4A is an alternative view of the apparatus of Figure 3A, shown in block diagram form and in accordance with the teachings of the present invention, including a sound unit. Figure 4B is an alternative view of the apparatus of Figure 3A, shown in block diagram form and in accordance with the teachings of the present invention, including a sound unit. 79 201208643 Figure 4C is a top plan view of a sound unit in accordance with one aspect of the present invention. Figure 4D is a diagram of a sound unit in accordance with one aspect of the present invention. Figure 4E is a diagram of a sound unit in accordance with one aspect of the present invention. Figure 5A is an illustrative example of a user wearing a detector and in contact with a device, shown in block diagram form in accordance with the teachings of the present invention. Figure 5B shows a possible physical shape of the device of Figure 5A having a device electrically coupled to the contact region in accordance with the teachings of the present invention. Figure 5C shows a possible physical shape of the device of Figure 5A having a device electrically coupled to the contact region in accordance with the teachings of the present invention. Figure 5D shows a possible physical shape for the device of Figure 5A in accordance with the teachings of the present invention having a device and a sound unit that are electrically coupled to the contact regions, respectively. Figure 5E shows a sound unit in accordance with one aspect and guidance of the present invention. Figure 5F shows a sound unit in accordance with another aspect and guidance of the present invention. Figure 6A is a view of the apparatus of Figures 5B, 5C and 5D, shown in block diagram form and in accordance with the teachings of the present invention. Figure 6B is the device of Figures 5B, 5C and 5D shown in block diagram form and in accordance with another aspect of the teachings of the present invention. Figure 7A is a view of the opening of the device of Figures 3, 3A and 5A in accordance with another aspect of the present invention, wherein a diaphragm is disposed adjacent the opening of the device through which the inhaled dose is delivered through the 201208643 . Figure 7B is a = (10) of the diaphragm of the device of Figure 7A divided into a few = when the user inhales the dose, the first beam is interrupted and the interruption is detected. The blade is a pattern of the diaphragm of the device of the diaphragm 7 A, wherein the film is divided into portions to cause the photograph. P-knife-chord movement and segmentation results in an interruption in a connection. The block ^ is one of the detectors of the picture recognition, the slave, and the eight-eighth. FIG. 9 is a block diagram of the processor of FIG. Figure (4) is an example of the invention of the invention of the county, the wearer and the case when the user inhales with a device. 4 contact for receiving-inhalation dose The device has the ability to record the timing of certain events associated with servicing the access device. Figure 12 is an illustrative example of a device in accordance with the teachings of the present invention, which is in the form of a device, which delivers a medical dose. The figure showing the guidance according to the invention is such that the medically delivered H is used for delivery by a pill reservoir - a separate pill. Figure 12C illustrates the view of Figure 12 of Figure 12 for the delivery of the Pill Storage H-individual (four) pill, which illustrates the use of Figure 28 in accordance with the teachings of the present invention. Delivery from a separate pill reservoir - a separate pill of the drug delivery skirt 201208643. Figure 13A is an illustrative example of a user wearing a detector and in contact with a device in accordance with the teachings of the present invention, shown in block diagram form, which delivers a medical dose. Figure 13B is a view of the medical delivery device of Figure 13A for delivering a separate pill from a tape containing a plurality of sealing pills therein in accordance with the teachings of the present invention. Figure 13C is a view of the tape in accordance with the teachings of the present invention, comprising a plurality of pills sealed in a package that can be coiled and inserted into a chamber of the device of Figure 13A. Figure 13D is a perspective view of the medical delivery device of Figure 13A for delivering a separate pill from a strip of a plurality of sealing pills therein, in accordance with the teachings of the present invention. Figure 13E is a top plan view of a tape delivery mechanism for liquid medical delivery from the perspective of one of the medical delivery devices of Figure 13A, in accordance with the teachings of the present invention. Figure 13F is a side elevational view of a tape delivery mechanism for liquid medical delivery from the perspective of one of the medical delivery devices of Figure 13A, in accordance with the teachings of the present invention. Figure 14A is an illustrative example of a user wearing a detector and in contact with a device in accordance with the teachings of the present invention, shown in block diagram form, which delivers a medical dose. Figure 14B is a view of the medical delivery device of Figure 13A for use in self-contained one of a plurality of sealed pills therein in accordance with the teachings of the present invention.
S 82 201208643 膠帶中輸送一單獨的藥丸,同時亦輸送一液體之劑量。 圖15A係為根據本發明之指導的一使用者配戴一偵測 器並與一裝置接觸的一說明性實例,其係以方塊圖形式顯 示,其輸送一醫藥劑量。 圖15B圖示根據本發明之指導的圖15A之該醫藥輸送 裝置的一觀點,其用於由一膀胱輸送液體醫藥之一單獨劑 量。 【主要元件符號說明】 AA 接點區域 BB 線路 3 裝置 10 使用者 20,20a 偵測器 20b 皮膚位置 20c 電容耦合器 20d 接點區域 20e 非接觸側 23 劑量確認裝置 25 裝置 27 電動化單元 30,30a 裝置 30b 電源 30c 電容耦合器 30d 接點區域 31 聲音單元 31a 處理單元 31b 聲音產生單元 31c 振動偵測單元 83 201208643 31d 麥克風 31e 放大器 31f 濾、波器 31g 數位器 31h 控制器 31i 電源 31j 電源 31k 放大器 31m 濾波器 31n 聲音產生單元 31p,31q 接點連接部分 31r 記憶體單元 32 外殼 33 聲音單元 33a,33b 連接部分 34 電源 35 磁鐵 36 控制單元 37 線圈 38,40 接點區域 41 固定線圈 41a,41b 連接點 42 記憶體單元 43 可移動線圈 43a,43b 連接點 44 腔室 45 固定平板 45a,45b 連接點 46 收發器 47 可移動平板 s 84 201208643 47a,47b 連接點 50 開口 52 膜片 52a-52f 部分 54a,54b 光束感應器 56 光束 58 光學間隙 58a,58b 阻抗測量單元 60 光學感應器 62 光源 70 處理單元 72 外殼 74 電極 76 線圈 80 放大器 82 導線 84 解調器 85 記憶體單元 86 時鐘 87 電源 89 收發器單元 90 模組 100 出入裝置 102 針部分 104 資料收集模組 106 出入口 210 偵測器 310 孔π 320 口配件 400 裝置 s 85 201208643 402 外殼 404 腔室 406 藥丸 406a 單個的藥丸劑量 408 輸送管 410 致動器 412,414 接點區域 416 藥丸閥 418 密封的包裝 420 電動式藥丸閥 500 裝置 502 外殼 504 膠帶 506 藥丸 508 藥丸輸送管 510 腔室 512 刀 514 膠帶指示器 522 膠帶 524 小袋 526 液體醫藥劑量 600 裝置 602 外殼 604 膠帶 606 第二腔室 608 輸送管 610 第一腔室 612 壁 614 液體 700 裝置 s 86 201208643 702 外殼 704 液體醫藥 706 加壓機構 708 輸送管 710 腔室 712 流量閥 714 通氣孔 716 囊袋 718 可移動平板 720 可移動活塞 87S 82 201208643 A separate pill is delivered in the tape while also delivering a dose of liquid. Figure 15A is an illustrative example of a user wearing a detector and in contact with a device in accordance with the teachings of the present invention, shown in block diagram form, which delivers a medical dose. Figure 15B illustrates an aspect of the medical delivery device of Figure 15A for delivering a single dose of liquid medication from a bladder in accordance with the teachings of the present invention. [Main component symbol description] AA contact area BB line 3 device 10 user 20, 20a detector 20b skin position 20c capacitive coupler 20d contact area 20e non-contact side 23 dose confirmation device 25 device 27 motorization unit 30, 30a device 30b power supply 30c capacitive coupler 30d contact area 31 sound unit 31a processing unit 31b sound generating unit 31c vibration detecting unit 83 201208643 31d microphone 31e amplifier 31f filter, waver 31g digital device 31h controller 31i power supply 31j power supply 31k amplifier 31m filter 31n sound generating unit 31p, 31q contact connecting portion 31r memory unit 32 housing 33 sound unit 33a, 33b connecting portion 34 power supply 35 magnet 36 control unit 37 coil 38, 40 contact area 41 fixed coil 41a, 41b connection Point 42 memory unit 43 movable coil 43a, 43b connection point 44 chamber 45 fixed plate 45a, 45b connection point 46 transceiver 47 movable plate s 84 201208643 47a, 47b connection point 50 opening 52 diaphragm 52a-52f portion 54a , 54b beam sensor 56 beam 58 Optical Clearances 58a, 58b Impedance Measurement Unit 60 Optical Sensor 62 Light Source 70 Processing Unit 72 Housing 74 Electrode 76 Coil 80 Amplifier 82 Conductor 84 Demodulator 85 Memory Unit 86 Clock 87 Power Supply 89 Transceiver Unit 90 Module 100 Access Device 102 needle portion 104 data collection module 106 access port 210 detector 310 hole π 320 port fitting 400 device s 85 201208643 402 housing 404 chamber 406 pill 406a single pill dose 408 delivery tube 410 actuator 412, 414 contact area 416 pill Valve 418 sealed package 420 electric pill valve 500 device 502 housing 504 tape 506 pill 508 pill delivery tube 510 chamber 512 knife 514 tape indicator 522 tape 524 pouch 526 liquid medical dose 600 device 602 housing 604 tape 606 second chamber 608 Duct 610 First Chamber 612 Wall 614 Liquid 700 Device s 86 201208643 702 Enclosure 704 Liquid Medicine 706 Pressurization Mechanism 708 Duct 710 Chamber 712 Flow Valve 714 Vent 716 Pouch 718 Movable Tablet 720 Removable Plug 87
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SG184839A1 (en) | 2012-11-29 |
CN102939046A (en) | 2013-02-20 |
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US20130172690A1 (en) | 2013-07-04 |
AU2011240845A1 (en) | 2012-11-08 |
CA2796283A1 (en) | 2011-10-20 |
WO2011130183A3 (en) | 2012-01-19 |
EP2557986A4 (en) | 2014-01-22 |
EP2557986A2 (en) | 2013-02-20 |
KR20130043101A (en) | 2013-04-29 |
IL222383A0 (en) | 2012-12-31 |
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