TW201208643A - Apparatus, system and method for detection and delivery of a medicinal dose - Google Patents

Abstract

An apparatus is disclosed as part of a system for tracking and confirming delivery of a medicinal dose to a user. The apparatus includes a detector. The detector is secured to and communicatively coupled to the user and is capable of detecting a current flow through the user's body. The current flow is produced when the user makes contact with the apparatus. The apparatus includes at least two contact areas connected to a power source where a circuit and, hence, a current path is completed through the user's body as the user makes contact with the apparatus. The current flow is detected by the detector, which is coupled to the user. Also disclosed is an apparatus for tracking and confirming delivery of a medicinal dose to a user where the apparatus includes an acoustic detector. Upon loading the dose into a chamber an acoustic vibration is generated. The vibration is detected and correlated with a current flow that is produced when the user makes contact with the apparatus. The combined event of vibration detection and current flow detection confirms that the dose is loaded and the user is in contact with the apparatus and ready to receive the dose.

Description

201208643 · VI. Description of the invention: [Technical field to which the invention pertains] Related application and reference to the present application claims to be filed on April 11, 2001, entitled "Used for the delivery of inhalable doses" System and method (System and

Method for Delivery 〇f an inhaiable Dose) ''US Provisional Patent Application No. 61/322,893; filed on June 22, 2010, for the detection of inhaled dose delivery U.S. Provisional Patent Application No. 61/357,506, to the System and Method for Detection of Delivery of an Inhalable Dose; and the application filed on August 13th, 2010, entitled "for U.S. Provisional Patent Application No. 61/373,803, the disclosure of which is incorporated herein by reference. This article is incorporated by reference in its entirety for reference. FIELD OF THE INVENTION The present invention relates to electronic systems and, more particularly, to electronic systems for determining and confirming delivery of medical doses. [Prior Art] A commonly used medical delivery system includes a chamber for storing the dose. The patient uses the system to take the medical dose as needed. However, there is no precise way to determine if a patient is taking this dose, or when the patient will take it. For example, having such delivery systems track the number of dispensings or deliveries. However, these delivery systems are unable to determine if and when

S 201208643. For example, the patient may discharge the number of swords taken during the short period of time for the delivery to be seen. With - some :; ~, has a time stamp on the delivery, but can not determine the patient actually, ί covers the dose. For example, the patient may vent the delivery system to see 'and not actually lick or inhale the dose'. The dose is regularly taken during a longer period of the heart-segment. Therefore, the rain delivery system cannot determine whether the patient actually receives the dose. The dose delivered by the tii sessile phase is actually delivered to the patient as a sound. For example, the delivery system may have been afflicted with the patient. In addition, in some instances, such delivery systems may have been placed out of the way. Therefore, the 'required system is a system and method for determining = the pharmaceutical agent 1 is intended to be delivered to a patient and tracking the delivery, and the patient is actually receiving the dose. . According to the present invention, the system and method of providing a system and method for the delivery of the amount of delivery to the face, and providing confirmation that the patient actually receives the dose. Fresh, unified includes the detector and;; device. The detector is coupled to the user and is capable of detecting that the current flowing through the user (4) m is generated when the user contacts the device. The device includes at least two contact regions connected to a power source such that when the user is in contact with each of the two contact domains, the -circuit 'and the current path are completed, and the one is combined with the latter. The detector detects a current flow. In another aspect, the system includes a detector and a device having a sound of 201208643. The detector is communicatively coupled to the user and is capable of detecting a flow of current through the body of the user and sound information generated by the sound unit. This current flow is generated when the user is in contact with the device. The device includes at least two contact regions coupled to a power source such that when the user is in contact with each of the two contact regions, a circuit is completed, and thereby a current path, and the Detector is coupled to the user The detector detects a current flow. [Embodiment] Referring to Fig. 1A, a user 10 is shown wearing a detector 20 and in contact with a device 3; the detector 20 and the device 3 will be described in more detail later. The detector 20 is shown to be fixed to a location of the user's body and is communicatively coupled to the user 10 and is capable of detecting a current flow through the user's body. However, the scope of the different aspects of the present invention is not limited to positioning the detector 20 on the user's body. The detector 20 can be secured to any location on the user's body. According to another aspect of the invention, the detector 20 is secured to the user's clothing. According to another aspect of the present invention, the detector 20 can be worn by a user in the form of jewelry, watches, clothing, and the like. In such a view, the detector 20 can be communicatively coupled to the user, for example, in contact with the user, closest to the user's body, and closest to the user's communication. In the presently illustrated example, the detector 20 is shown as a detector external to the user. According to another aspect of the invention, the detector 20 can be positioned or implanted within the user. In another aspect of the invention, the detector 20 can be partially implanted within the user. Institute research

The in vitro secure detector 20 of S 201208643 includes such elements that are suitably sized to be stably coupled to a living body in a manner that does not substantially impinge on the movement of the living body. As such, the detector 20 can have dimensions that, when secured to the user 10, will not cause the user 10 to experience any differences in mobility or movement. In accordance with some aspects of the present invention, the detector 20 is sized such that its dimensions do not interfere with the ability of the living body to move on the body. For example, in one aspect, the detector 20 has a small size and occupies a volume of 5 cubic centimeters or less, such as 3 cubic centimeters or less, including 1 cubic centimeter or less. In another aspect, the detector 20 has a small size and occupies a volume of 25 cubic centimeters or less, such as 12 cubic centimeters or less, including 5 cubic centimeters or less. In another aspect, the detector 20 has a small size and occupies a space of 25 cubic centimeters or less, such as 5 cubic centimeters or less, including 1 cubic centimeter or less. According to one aspect of the invention, a receiver (not shown) can be included in the apparatus 3. In these examples, the receiver has a wafer size limit ranging from 2 square centimeters to 2 square centimeters. The user 10 holds the device 3 in the user's hand and positions the device 3 to the user's mouth to contact the device 3 in at least two positions, as shown. In the case of a child, the parent can hold the device 3. In a different view, if the child is in contact with the parent, a circuit is completed via the parent and the child as explained below. To clearly illustrate the functionality of the device and the components therein, the device 3 is shown in block diagram form. However, according to a different point of view of the present invention, the device 3 can be constructed in a variety of shapes in 201208643. Referring now to Figures IB, 1C and id, the device 3 can be of a variety of shapes '"# different views, with - chamber ΐ = and / or early dose, each agent 鼍 匕 3 Several cough users 10. Figure Wf is delivered for a period of time until 1C shows that the device 3 is a single dose inhaler having a chamber capable of containing a dose. Name and entry. 1Λ ^ Then the chamber is refilled after the early dose is delivered to the user 10. Figure 1D shows that the inhaler can continuously deliver a delivery-dose, or in a predetermined two-use combination with a - power supply - the motorized unit 27 delivers a clear = T inhaler plus a woven shape that is considered to be within her mouth. Thus, according to a different point of view of the present invention, the device 3 can be loaded for different shapes and doses, as in Figures 1B, 1 (and 1D: no), and the invention is not limited thereto. The actual shape or dose delivery pattern or dose delivery timing of the device. a. From a different perspective, the exemplary device 3 may comprise a sound unit or a sound unit according to a different aspect of the present invention as shown, for example The device 3 and the device 25 shown in Figures 3B and 5B, respectively, are described in more detail below. Referring now to Figure 2A, the device 3 includes a housing 32, a power source, and a Control unit 36, contact areas 38, 40 and a memory unit 42. The housing 32 defines a chamber 44 for containing the inhalable dose. The chamber 44 can also include a chamber control unit for controlling the dose. Dispensing the chamber 44 further includes an opening through which the inhalable dose is delivered

S 8 201208643 Patients, as described below in relation to Figure 7A. According to one aspect of the invention, the outer casing 32 includes at least two contact regions/points 38, 40 that are disposed at different locations on the outer casing 32. The location and location of the contacts 38, 40 or regions are determined by the shape and design of the device 3 and from the different perspectives of the present invention. For these contact regions 38, 40, a plurality of locations can be considered. According to another aspect of the present invention, the contact areas 38, 40 may include functionality that allows for biometric authentication information, such as reading and recording of fingerprint data. This information can be communicated to the device 3 and stored therein for confirmation by the user. The contact regions 38, 40 are electrically isolated from each other and at least partially exposed or exposed to bring the user 10 into contact therewith. In one aspect, the contact regions 38, 40 can also be coated with a thin dielectric material, such as plastic, and electrical communication with the user via the dielectric material using capacitive coupling. Capacitance fit can be done at signal frequencies greater than about 20 kHz, and in some respects, a good signal-to-noise ratio (SNR, such as signal-to-ambient noise) is achieved at 80 kHz. According to one aspect of the invention, the contact regions 38, 40 are positioned such that a contact region 38, for example, is in contact with the user's hand, and another contact region 40, for example, in contact with the user's mouth . In accordance with an optional aspect of the present invention, additional contact areas can be added to allow for a second contact with the hand or mouth and for a different hand accommodation, such as a left hand grip or a right hand grip. . Further, an additional contact area on the outer casing 32 can be included to ensure that the device 3 is properly held. If the contact areas 38, 40 are covered by a dielectric material, the device is in contact with the user's mouth, and the 201208643 user may or may not be able to see the electrodes. For example, the electrodes can be incorporated into the plastic material and capacitively coupled to sense the presence of the port and look for a large change in impedance between the two capacitive plates when the port contacts both of the plates. . It should be appreciated that the contact regions 38, 4A can be disposed proximate to or on the outer portion of the outer casing 32. In one aspect, the contact regions 38, 40 can be "partially exposed," and in another perspective can be "embedded" in the outer casing 32. In other aspects, the user can use non- The contact method is combined with the contact regions 38, 4G, such as detecting a change in electric field when the user approaches the contact regions 38, 40. The power source 34 is electrically coupled to the control unit % and is connected thereto. The point areas 38, 4G are engaged. The terminal of the power source 34 is electrically connected to the domain 40. The other terminal of the power source 34 is electrically connected to the control unit %. As shown, the power source 34 has two outputs; The output is electrically connected to the control unit 36 and the further output is connected to the contact area %. In the example, the control unit 36 is connected in series with the power source 34. However, the invention is not limited to the control. The fresh element 36 is in a relative circuit relationship with the surface, 34. For example, the control unit 36 can be configured in conjunction with the "control unit 36", the contact area 3, and the power source 34. The two terminals are electrically connected. It should be appreciated that in some instances the power source 34 produces an alternating current (AC) signal so as not to cause the heart to move: other signals may be used if safe for life is considered. When the device 3 is in contact with the user's hand and mouth, the contact areas 38, 40 are in contact with the user 10, creating a two-turn circuit including the user (7). Accordingly, the circuit defining the current path includes the user 201208643 Η), the contact area 40, the power source 34, and the control unit point area 38. The current path - after completion, the power source (4) is used to cause the voltage required to flow through the body of the manufacturer. Since Wei set 3 is now in the user's hand, the sub-contact has been in contact with the user's mouth, so the appearance is that the $3 line is in the indicator for dispensing the absorbable dose. The stomach 2 identifies the presence of current flow through use and is capable of recording the timing of the occurrence of the event, as described in more detail below. In addition, the device 3 can also measure the presence of the current flow and record the event (4). Thus, once the circuit is completed and the current flow is detected, the control unit 36 is also capable of recording the timing of the completion circuit in the memory unit 42. " According to another aspect of the invention, the control unit 36 provides additional control functionality. According to one aspect, the control unit 36 is capable of controlling the electrical conductivity of the circuit, which is accomplished by the body of the user to encode the information in the current flow. In addition, the control unit can superimpose information stored in the memory and also stored in the flow of the stream. For example, the timing of the completion of the circuit' dose related information, or additional identification information, can be encoded in the current flow. The control unit 36 changes the electrical conductivity of the circuit. The altered conductivity results in a change in the characteristics of the current flow. The characteristics of the changes are the inclusion of the information and the encoding of the information in the current flow, as described in U.S. Patent Application Serial No. 12/564,017, filed on Sep. 21, 2009, which is incorporated herein by reference. (COMMUNICATION SYSTEM WITH PARTIAL POWER SOURCE), and is disclosed in US 2010/0081894, the entire disclosure of which is incorporated herein by reference. The encoded information is thus detected and decoded by the detector 20. In addition, U.S. Patent Application Serial No. 11/912,475, filed on Apr. 28, 2006, is hereby incorporated by reference in its entirety in its entirety in its entirety in Incorporating this case into a reference. Further, in accordance with another aspect of the present invention, the control unit 36 can enter a sleep state to minimize power consumption. The control unit can be returned to an active state by one or more known methods including power, heat, pressure, sound, and the like. In case the sound is used, the sound vibration generated by loading the dose entering the chamber 44 can be used to generate an activation signal which is sent to the control unit 36 by a sound unit, for example. The enable signal can be used to set the control unit 36 from the sleep state to an active state. Upon activation, the control unit 36 is capable of recording additional audio information, particularly information relating to inhalation by the user 10 via the device 3. Referring now to Figure 2B, in accordance with another aspect of the present invention, the control unit 36 is also capable of controlling communication using additional or optional communication channels, such as wireless and optical. The control unit 36 is coupled to and coupled to a transceiver 46, which may be included in an optional view of the device 3. The revenue benefit 46 is configured to transmit and/or receive information from the device 3. Although the communication is illustrated in terms of transmission of the teleporter 46, in accordance with another aspect of the invention, a receiver (not shown) may be included in the apparatus 3 and electrically coupled thereto. Hai control unit 36. Still further, in accordance with another aspect of the present invention, the transmitter 46 can be replaced by a transceiver unit capable of processing the transmission and reception of information. 12 201208643 Thus, the control unit 36 allows the device 3 to communicate with the detector 20 using a plurality of communication channels and methods. In one aspect, the transceiver is configured to communicate with an external device, such as a mobile phone or a personal computer, to indicate that the inhalation event has occurred. It can be replaced by wireless communication or wirelessly indicating that the user has inhaled in addition to generating a signal. The device 3 is capable of communicating with other different devices, such as a computer with a built-in or peripheral monitor (such as seen in a bedside monitor or a Kangbeicheng system) 'a number of assistants (pDA), one Smart phone '-message device' - data center, etc. In addition, the device 3 can be configured to communicate, for example by inquiring, by using an external device or by receiving data to an external location. Any suitable data may be used including via the body (e.g., using current to flow through the traitor) and via both, such as a wireless transfer protocol. According to another aspect of the present invention, the detector 2() transmits an identification code or a value of 3°. The identification code or information activates the device 3 for transporting the second detector 2 to confirm the delivery of the dose. And transmitting a message to the device 3 indicating that the dose is delivered. According to another aspect of the present invention, the detector is directly and independently connected to a second device, a device 3, a thunder, or a spear-like device, such as a mobile phone or Promotion = < News of the Wei system is related to the delivery of this dose. This third F = adjusts the information and information used to make the delivery time: the patient's identity and other relevant factors ^ or the device 3 receives. The mother unit 7 is self-testing device 20 and still referring to FIG. 2A, the control unit 36 is positioned in parallel with the power source 34 13 201208643 because the control unit 36 is connected to each of the contact regions 38, 40. However, the scope of the present invention does not limit the relative circuit position of the control unit 36 and the power source 34 within the circuit that is completed by the user's body. For example, the control unit 36 can be configured in series with the power source 34 such that an output of the power source 34 is coupled to the control unit 36 similarly to that shown in Figure 2A. As explained above, the control unit 36 controls the conduction characteristics of the circuit and hence the characteristics of the current flow. Thus, the control unit 36 can encode the tribute in the current flow and allow the current characteristic to carry information to the detector 20. Referring now to Figure 3A, the user 10 is shown wearing a detector 20 for physical contact with a device 30. The device 30 is similar to the device 3 previously described, and in a different perspective, the device 30 includes a sound unit 33, as shown in Figures 3B-3D. For example, in Figure 3B, the sound unit 33 is shown to be in the path of the airflow, but not on the path of the medicine. In Figure 3C, the sound unit 33 is shown to be in the path of the airflow and medicine. In Figure 3D, the sound unit 33 is shown on the path separating the airflow from the medication. This category of the invention is not limited to the position of the sound unit 33 relative to the path of the airflow and medicine. The different views of the detector 20 from the device 30 will be described in more detail below. The user 10 holds the device 30 in its hand and places the device 30 to the user's mouth, thereby making contact with the device 30 at at least two positions, as shown. For young children, the parent can hold the device 30. In order to clearly illustrate its functionality and the components therein, the device 30 is shown in a block diagram. However, according to different views of the present invention, the package

S 14 201208643 The setting 30 can be configured in a plural shape. Referring now to Figure 3E, the user 1G is shown in contact with the device 3Ga via the contact area AA. The figure shows that the device has a power supply, a power supply, a face benefit 30c and a contact area 3 () d. The capacitor combiner 3〇c is electrically isolated from the "helium contact area 3〇d". The contact area is defined as an electrode or plate that represents the side of the capacitor opposite the ground. It is also shown that the user 10 is wearing - the detector 2A includes a capacitive coupler 20c_. In Figure 3E, a capacitance-conducting path is shown between the capacitive couplers 3〇c, 2〇c with a dashed line. In this figure, the physical contact between the user 10 and the device 3A is indicated by line AA. It will be apparent that the contact between the user 10 and the device 3A is in fact a physical contact and can occur between the mouth or hand of the user 10 and the device 3A. This category of the invention is not limited to the area of the device 3A that is in contact with the user 10. For example, any part of the user's contact with the contact area 30d is within the scope of the present invention, such as the application for PCT patent application pCT/2〇11/23 on January 28, 2008. No. 17, titled "TWO-WRIST DATA GATHERING SYSTEM" and the application for PCT Patent Application No. PCT/2011/23013 on January 28, 2008, titled Wrist Data Collection System ( WRIST DATA GATHERING SYSTEM), the entire specification of each of which is incorporated herein by reference. Referring now to Figures 3E and 3F, the detector 20a is shown in an exploded view at a skin location 20b of the user 10. The capacitive coupler 20c includes a contact area 20d that is in contact or nearly in contact with the user at the skin location 20b and a non-contact side 2〇e. The power source 3〇b is physically coupled to the contact side 20d via the body of the user 10 and the contact area 30d. The circuit shown in the figure is used to illustrate a patch according to one aspect of the present invention. The capacitive coupler 30c is coupled to the capacitive cake of the detector 20a via an electrical connection of the air and/or ground. The combiner 20c is joined. A capacitive coupling occurs between the device 3A and the detector 2A. Therefore, according to another aspect of the present invention, the device 3A includes a contact area 30d which is in contact with the patient, and a second contact area, the electric valley engaging area 30c' is associated with the patient isolation. The device 3A uses a capacitive return path via space and ground to the receptor. Thus, by using the control module of the device 30a, the information is encoded in the carrier using well known techniques to control the isolation characteristics of the power supply 3A. For example, frequency shift keying (FSK) can be used to encode information into the carrier, including the binary FSK. Referring now to Figure 4A, the apparatus 3A includes a housing 32, the sound unit 33, a power source 34, a control unit 36, contact areas 38, 4A, and a memory unit it 42. The angled housing 32 defines a chamber 44 for containing the inhalable dose. The chamber 44 can also include a chamber control unit for controlling the dispensing of the dose. The chamber 44 can also include an opening through which the inhalable dose is delivered to the patient, as described below with respect to Figure 7A. According to the invention m, the contact regions/points 38, 4 are arranged at different locations on the outer casing 32. The location and location of the material contacts 38, 4q or regions are determined by the device 3G cut and design and in accordance with the present invention. A plurality of locations can be considered for the contact domains 38, 4G'. 201208643 The contact regions 38, 40 are electrically isolated from each other and at least partially exposed to allow the user 10 to be in contact therewith. According to one aspect of the invention, the contact regions 38, 40 are positioned such that a contact region 38, for example, is in contact with the user's hand, and another contact region 40, for example, in contact with the user's mouth . In accordance with an optional aspect of the present invention, additional contact areas can be added to allow for a second contact with the hand or mouth and for a different hand accommodation, such as a left hand grip or a right hand grip. . Further, an additional contact area on the outer casing 32 can be included to ensure that the device 30 is properly held. According to another aspect of the present invention, the contact areas 38, 40 include functionality for reading and recording biometric authentication information such as fingerprint data. This information can be communicated to the device 30 or the sound unit 33 and stored therein for confirming the identity of the user. The power source 34 is electrically coupled to the sound unit 33, the control unit 36, and coupled to the contact regions 38, 40. The sound unit 33 is also electrically coupled to the control unit 36 and its operation is illustrated in relation to Figures 4C, 4D and 4E. One of the terminals of the power source 34 is electrically connected to the contact area 40. The other terminal of the power source 34 is electrically connected to the control unit 36. As shown, the power source 34 has two outputs; an output system is electrically coupled to the control unit 36 and the other output system is coupled to the contact area 38. In this example, the control unit 36 is coupled in series with the power source 34. However, the scope of the present invention is not limited to the relative electrical relationship between the control unit 36 and the power source 34. For example, the control unit 36 can be configured in parallel with the power source 34 such that the control unit 36 is electrically coupled to the contact regions 38, 40 and the terminals of the power source 34 201208643. Further in accordance with another aspect of the present invention, the control unit % can enter a sleep state to minimize power consumption. In this case, any event that causes a change in state can be used as a start signal, for example, to cause the sound of the sound generated by the chamber 44 to be generated by the dose loader, which is transmitted to the sound unit 33. control unit%. The activation signal can be used to set the 4 control unit 36 from the sleep state to the active state. After the activation, the unit (36) can record additional sound information, in particular with the user 1 吸 via the device 3 Q Information about people. Domain 38^=when the user's hand is in contact with the mouth, the contact areas are in contact with each other, generating a circuit including the user 10, thus defining the circuit 10, the contact area 40, The power supply 34, the control unit 36, and the second and second terminals are used to provide the voltage required to cause the current to flow to the body. Since the device 30 is now in contact with the user's mouth, the current flows ', ', ,, °, and 3 〇 in the correct position indicator for dispensing the inhalable dose. . The detector 2 identifies the current flowing through the user's body, and is able to record the timing of the occurrence of the event, as described in more detail below. The current flow is recorded in the scale phase. So, once the circuit is completed and . The control unit 36 is also capable of recording the timing of the completion circuit in the memory element 42. Referring now to Figure 4, in accordance with another aspect of the present invention, the control unit % 201208643 can also use an additional or optional communication channel, such as wireless and optical, to control communication. The control unit 36 is coupled to and in communication with a transceiver 46, which may be included in an optional view of the device 30. The transceiver 46 is configured to transmit and/or receive information from the device 30. Although the communication is illustrated in terms of transmission from the transmitter 46, in accordance with another aspect of the present invention, a receiver (not shown) can be included in the device 30 and electrically coupled to the control unit 36. Still further, in accordance with another aspect of the present invention, the transmitter 46 can be replaced by a transceiver unit capable of processing the transmission and reception of information. Thus, the control unit 36 allows the device 30 to communicate with the detector 20 using a plurality of communication channels and methods. In one aspect, the transceiver is configured to communicate with an external device, such as a mobile phone or a personal computer, to indicate that the inhalation event has occurred. It can be replaced by wireless communication or wirelessly indicating that the user has ingested in addition to generating a signal. The device 30 is capable of communicating with other different devices, such as a computer having a built-in or peripheral monitor (such as seen in a bedside monitor or a health information system), a number of PDAs, Smart phone, a message device, a data center, etc. Additionally, the device 30 can be configured to communicate, for example by interrogation, with an external device for providing data to an external location. Any suitable data transfer protocol can be used, including via a body medium (e.g., using current flowing through the user's body) and via air, such as a wireless data transmission protocol. According to another aspect of the invention, the detector 20 transmits an identification code or information to the device 30. The identification code or information activates the device 30 for the delivery of the agent 19 201208643. In addition, the detector 20 can confirm the information to the placement 30' and transmit another point according to the present invention. The detector 2 is directly and independently associated with a third device. computer. The communication information and the dose wheel '2 move = or = will adjust the information and information used - patient identity and other relevant factors, JJ ~ 钊, and / or the device 30 received. The parent may still commit the reference from the detector 20, and the control unit 36 is connected in parallel because the control unit 36 is connected to each of the power supply 34 = 'the second edition of the invention. The control unit 36 and the power supply unit can be associated with the power supply 34/position, for example, the output system and the power supply 34 36. As explained above, the control unit 3 is connected to the control unit and thus the characteristics of the current flow. The circuit, the conduction characteristic, encodes the information in the current path, and the unit 36 can be coupled to the detector 20. each. 〇 Current Characteristics Mounting Information Referring now to Figure 4C, in one aspect, an iron 35 and a coil 37 are used. The coil 3 ^ 3 early includes a magnet to the control unit of Figure 4A. The center of gravity 3 is mounted on a movable or deflectable surface, and 1 is secured to or secured. The (four) unit 36 measures when the _, 37, ^^ is moved within the magnetic field of the magnet % or is generated by the = magnet 35 associated with the machine. The coil 37 20 201208643 magnet 35 _ the change in position 'change in distance' causes a change in the system. Therefore, the control unit 36 of the coil 37 in the magnetic field of the magnet 35 by the inhalation or the medical negative = acoustic wave can detect the sound wave via the coil 37. Referring to FIG. 4D 'in accordance with another aspect of the present invention, the cymbal cymbal 33 includes a fixed green ring 41 and - the acoustic coil 41 is coupled to the source ring 43 via the connection points 41a and 41b: The power of a coil 41 causes the fixed magnetic field. The movable coil 43 is disposed close to the door circumference, and the connection points 43a, 43b are connected to the control unit = circle 2, and the % is detected by the movable coil 43 and the presence of the fixed binary system . The change in the distance as the movable coil 43 is associated with the inherently associated position change causes a change in the characteristic of the electromagnetic field in the phase of the fixed ^, '=4^. When the user i = is associated with the person or is inhaled via the device S 30, the synthesis = the movement of the edge medicine feed coil 43. Therefore, by the inhalation or the sound wave generated by the transfer, the fixed coil q electromagnetic: the movement 36 carrying the rim via the movable line is now referred to FIG. 4E, according to the present invention Alternatively, the η = display includes a fixed plate 45 and a movable plate 47. ; Hai = 5 is connected to the power source 34 via connection points 45a and 45b. The power supply for the sputum ^ / - plate 45 causes the 5 hai 6 hai movable plate 47 around the fixed plate 45 to be positioned closest to the fixed plate. 21 201208643 is connected to the control by the connection points 47a, 47b. The fixed plate 45 is measured by the movable coil 43 and the capacitance of the reverse 47 is combined. As the relative position of the movable plate π plate 45 is changed, the movable coil is changed between the fixed plate 43 and the movable plate 47. When the user H) selects the characteristic of the capacitor associated with the patient, the synthetic sound wave arrives at the movable tablet or the second load: the medical use The sound waves generated by the conveyor are guided by more than 47 movements. Therefore, the control unit multi-moves the side acoustic waves. ^ (4) Removable Coil 43 The advantage of the present invention is that the acoustic sensors enable the manufacturing process of printed circuit board manufacturing, or coloring, to be constructed at a low cost. By using an additive print, the circuit of the control 7G can be obtained in the "circuit, board ± according to the present invention". Further, according to the present invention - viewpoint The power source can be incorporated into the assembly. According to a different aspect of the invention, the sound unit 33, as indicated above, can be configured at different locations within the device 30 (Fig. 3A), such as in Fig. 3D. Detach from the airflow path and the medical path, as shown in Figure 0, in the airflow path and away from the medical path, or B in the airflow path and in the medical path In addition, according to another aspect of the present invention, the sound unit 33 can be set to be internal or external to 30. Referring now to the ® 5Α, a user 1 is shown wearing a predator 2〇 and with a Ο 22 201208643 The # drug delivery device 25 is in physical contact; the detector 20 and the device 25 will be described in more detail below. The user 10 will be in a difficult position 25_ and placed the device 30 in the use The mouth of the person, so that the device 25 is in contact with at least two positions, as shown in the figure No. For young children, the parent can hold the device 25. The fake f child is in contact with the parent', as explained below, via the parent and child = ▲ circuit. The 6 hai device 25 defines a chamber for The chamber may further comprise a chamber controller unit for controlling the delivery of the dose. The chamber also includes an opening σ through which the inhalable dose is delivered to the chamber The patient's description is as follows in relation to the figure. As in the case of the maps 5B, 5C and 5D, according to different views of the present invention, the farm 23 is fixed to the device 25, which can be a plurality of ^οα In view of the fact that the dose confirming device 23 includes a sound, for example, 'Fig. 5' shows that the dose confirming device 23 is fixed to the m and the contact regions * 38, 40. The dose confirming device η Package == 31. The device 25 is a one-chambered-upright suction=sufficient text-pressure tank containing multiple or single-dose, wherein two are shown: each dose is delivered individually to The user 10. Figure 5C '-agent i is a single dose inhalation 11 having a chamber capable of containing After the dose is delivered to the user 1G, the dose confirming device 23 and the sound such as the moxibustion test unit can be individually fixed to the split 25. > Referring to Fig. 5D, the dose confirming device 23 and the sound unit are 23 201208643 蜀, f and f" respectively fixed to the device 25. The dose confirming device 23 and the 亥 声 单元 unit 31 are connected to each other and connected The fresh contact area 38, 4 〇 ° ^ ^ 25 is the inhaler, which can be used to turn on a power supply of a motorized unit 27 for continuous delivery of __ dose, or at - pre-interval Deliver a dose. The power source disclosed in accordance with the teachings of the present invention may be an alternating current (AC) power source or a direct current (DC) power source. Furthermore, the power supply is designed to ensure that this current flow can be used for the life body within the safety parameters. Additional examples and shapes for delivering an inhalable dose are contemplated and are within the scope of the present invention. Thus, in accordance with various aspects of the present invention, the device 25 can be of different shapes and dose delivery equipment, as shown in Figures 5B, 5C, and 5D, and the scope of the invention is not limited to the actual shape or The dose delivery mode or the dose delivery timing of the device. Furthermore, the scope of the present invention is not limited to the fact that the device 25 includes the sound unit 31 or the sound unit 31 is separated from the device 25. More specifically, each has a particular function and purpose, and acts on its own and works separately with each other. Accordingly, any device 'comprising any conventionally known or conventional inhaler can be used in conjunction with either or both of the device 25 and/or the sound unit 31 to confirm delivery of a sword to the user 10, No structural changes or modifications have been made to the device 25. According to one aspect of the present invention, the sound unit 31 includes an aperture for generating sound when the user 10 inhales. In a manner similar to the horn, the sound is generated by the airflow through the sound unit 31. The sound unit 31 is equipped with f on the path of the air flow. When the user inhales the airflow

S 24 201208643 Through the device 25 and the sound unit, referring to FIG. 5E, according to the other point of view (4), the sound signal generated by the =" is detected in the sense of the user ι 〇 ... ... .... The sound unit 31 includes a processing early tg3la having a -memory unit, a sound generating single open 1 early 3'b'-vibration detecting unit 3Ic, and a power source 311. When the money user 1 is via the mobile unit 31C_ Vibrating and sensing the detection event. The signal is sent to the processing unit 31a to indicate that the user has been inhaled. The processing unit 31a sends a letter to the sound generating unit 3ib = for generating a sound Further, the vibration test unit w can also detect the vibration generated by the device when the dose load enters the chamber as described below. The load with the dose is inhaled by the user. The associated vibrations respectively produce a unique vibration characteristic (10), such as signature, 'monthly enough to use independently or collectively to confirm that the dose f is sent to the user. Further, according to the present invention Another point of view is that the sound unit 31 can be connected via one The transceiver communicates with an external device, such as a mobile phone δ tongue or a personal computer, as described herein, to indicate that the inhalation event occurs. Wireless communication may replace or in addition to generating a signal, such as, for example, the The sound signal, using wireless communication, indicates that the user has inhaled. Referring now to Figure 5F, in accordance with another aspect of the present invention, the sound unit 31 includes a power source 31j and a microphone 31d. The microphone 3Id is detected by / or loading the dose into the chamber of the device 25 for transporting the generated acoustic vibrations. Therefore, it is possible to independently detect the event of loading the dose intended to be delivered, as well as the actual event that is inhaled during delivery. Measure 25 201208643 ^ tone-amplifier 31e and a chopper 31f, to a digital or analog-to-digital converter 31g. The filter 祀, according to one of the inventions, is a low-pass filter. The digitizer is called Provide a digital signal micro-production t-generation 3] Bu 4 control thief 3] h can be - programmable processor or 妓 processing b, which can be programmed to program and rewrite the program. The sound information of the sound information generated by the inhalation event has well-known characteristics. For example, "filling t = when the device is inhaled, - the sound generated by the special device is hunted by each device when the dose is inhaled = ==, the known range, and when the user 10 state machine is available to replace the characteristics of a micro-processing Q, a state machine or a finite state controller 31h is two = can be two thus 'according to the invention - Viewpoint 'The controller Μ Μ 如 如 : : : : : : : : : : 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产 产夕 I Yang Zhuo:: The signal of 31n includes the unique feature of the Yuan 31 series. = Identification information for the sound of the single and the 褒 fill into the ί 25; ===_ or agent and the user 10 The information associated with the production and sequence is transmitted to the detector 20 by the sound unit 3l s, which is then transmitted by the second signal 31. The unit 1G of the 1G _ is made up of 9 彳 5 唬, as explained below. In this way, any device,

S 26 201208643 includes any conventional inhaler that can be used with the sound unit 31 to confirm delivery of a dose to the user, and two pairs of devices for delivering the dose Structural changes or modifications. As indicated above, in accordance with another aspect of the present invention, the sound unit 31 can communicate with the transceiver to indicate that the inhalation event has occurred. According to another aspect of the present invention, the sound unit 3A also includes contact connecting portions 3lp and 31q. The contact connecting portions 3lp and 31 (1 is electrically coupled or connected to the contact regions 38 and 40' are described below with reference to Figure 6a. The information collected by the controller 31h, such as physiological The learned or production information 'is stored in the memory unit 31r for later querying the fish=set. According to another aspect of the present invention, the sound unit 31 includes a wireless communication module, such as a Bluetooth ( The Bluetooth® module communicates with an external device using very low power consumption. For example, the external device can be any commercially available hardware/software device such as a mobile phone, computer, network router, and distance. The medical base 'and the desired technology such as a single-chip, a receiver, and a key fob. Therefore, the scope of the present invention is not limited to the type of device that the sound unit 31 communicates. The present invention is not limited to devices of this type that communicate with the device 25. Further, the parent exchanges information including the fireware image, the collected unprocessed data, and the generated information. Data management information Configuration Information Referring now to Figure 6A, the dose greening device 23 is shown in block diagram form to clearly illustrate its functionality and the components therein. However, 27 201208643 the dose confirmation device 23 can be based on a particular The design needs and the shape of the device 25 are formed in a plurality of shapes. The dose confirming device 23 includes a power source 34, a control unit 36, contact regions 38, 40, and a memory unit 42. According to one aspect of the present invention, The outer casing 32 includes at least two contact regions/points 38, 40 disposed at different locations on the outer casing 32. The locations and locations of the contacts 38, 40 or regions are by the shape and design of the device 25, and according to the present Different aspects of the invention are determined. The plurality of locations for the contacts 38, 40 are considered. Further, the contact regions 38, 40 may be part of the device 25 or part of the dose confirmation device 23, or A portion of the sound unit 31. According to another aspect of the present invention, the contact regions 38, 40 can be separately and independently attached to the device 25, allowing customization of the contact regions 38, 40. The dose confirmation device 23 or the location of the sound unit 31 is on the device 25. According to another aspect of the invention, the contact regions 38, 40 can include reading and recording biometric authentication information, such as fingerprint data, The information can be communicated to the dose confirmation device 23 or the sound unit 31 and stored therein for confirming the identity of the user. When the device 25 is in contact with the user's hand and mouth, Contacting the contact areas 38, 40 with the user results in a complete circuit including the user 10. Thus, the circuit defining the current path includes the user, the contact areas 40, the power source 34, and the control unit 36 and the contact area 38. Once the current path is completed, the power source 34 provides the voltage required to cause a current to flow through the body of the user. The presence of the current flow is an indicator that the device 25 is in the correct position for dispensing the smokable

S 28 201208643 The dose entered because the device 25 is now in the user's hand and has been in contact with the user's mouth. The detector 2 identifies the presence of current flow through the user's body and can record the timing of the event, as will be explained in more detail below. Thus, once the circuit is completed and the current is detected to flow, the control unit 36 is also capable of recording the timing of the completed circuit in the memory unit 42. Referring again to Figures 5E and 5f, the processing unit 31a and the controller 31h may perform the functions of the control unit 36 in accordance with various aspects of the present invention. According to another aspect of the invention, the control unit 36 provides additional control functionality. According to one aspect, the control unit 36 can control the conductivity of the circuit 'by the user's body to encode the information in the current flow. For example, the timing of completion of the circuit, information relating to the dose, or additional identification information may be encoded in the current flow. The control unit 36 changes the conductivity of the circuit. The altered conductivity results in a change in the characteristics of the current flow. The characteristics of the change include the information and thus the information is encoded in the current flow, as described in U.S. Patent Application Serial No. 12/564,017, filed on Sep. 21, 2009, which is incorporated herein by reference. The disclosure of the entire contents of this specification is incorporated herein by reference. The encoded information is then detected and decoded by the detector 20. Additionally, in accordance with another aspect of the present invention, the control unit 36 can enter a sleep state to minimize power consumption. In this case, the vibration generated by the dose loaded into the chamber 44 can be used to generate an activation signal from the sound unit 31 (Fig. 5D) to the control unit 36. The enable signal can be used to place the control unit 36 in an active state by the sleep state. Upon activation, the control unit 36 is capable of recording additional audio information, particularly by the user 10 inhaling information via the device 25. Referring now to Figure 6B, in accordance with another aspect of the present invention, the control unit can also control communication using additional or alternative communication conduits, such as wireless and optical. The control unit 36 is coupled to the second transmitter 46 for communication, and includes a node conveyor in an optional view of the dose confirmation device 23. Although the communication system illustrated is derived from the transmitter, in accordance with the present invention, the dose confirmation device can include - receive H (not shown) and electrically connect to the (4) Unit % = 虞ίΓί Another point of view is that the transmitter 46 can be replaced by a transceiver unit that handles the transmission and reception of the beacon. Therefore, the control unit 1 determines that the dose is set to "the number of _ external device communication, such as line =: 3 is organized to - inhalation event. The wireless communication computer can be used to indicate that the signal is generated and the line is also used. In addition to generating a dose confirmation device 23, the blood can be communicated from the τ 1 with a different communication device, such as having a guilt or A computer in the peripheral monitoring device (or a person in a health information system, I see the benefits - smart phone, - message device) - f - two people (intestines), the dose confirmation of the farm can be 23 Construction (four) by = center. In addition, the machine is used by an external device to provide an external location. Any suitable data transfer protocol can be used, including via a body medium (e.g., using current flowing through the user's body) and via air, such as a wireless data transmission protocol. Referring again to Figure 6B, since the control unit 36 is connected to each of the contact areas 38, 40, the control unit 36 is arranged in parallel with the power source 34. However, the scope of the present invention is not limited to the relative circuit position of the control unit 36 and the power source 34 within the circuit that is completed by the user's body. For example, the control unit 36 can be configured in series with the power source 34 such that an output of the power source 34 is connected to the control unit 36 similar to that shown in Figure 6A. As described above, the control unit 36 controls the conduction characteristics of the circuit and thus the characteristics of the current flow. Thus, the control unit 36 can encode the information in the current path and allow the current characteristics to carry information to the detector 20. Referring again to Figure 5A, the detector 20 is shown secured to the body at a location. The location of the detector 20 is determined by the medical requirements and system. The detector 20 used in accordance with various aspects of the present invention is configured to be combined with a body position (inside, inside, or on a surface of the body) for detecting one or more Current and electrical signals for multiple devices, such as device 25 of Figure 5A. Attachment of the detector 20 to the garment of the subject, attachment of the electrode lead/wire to the skin of the subject or otherwise contacting the skin of the subject is also within the scope of the present invention. Referring now to Figure 7A, in accordance with one aspect of the present invention, the apparatus 3, 30, 25 (as described above with respect to Figures 1A-6B) is shown with an opening 50 and a diaphragm 52. The diaphragm 52 is shown to have six sections 52a, 52b, 52c, 31 201208643 52d, 52e and 52f. The diaphragm 52 is positioned between the device 3, 30, 25 and the opening 50. Accordingly, when the dose is dispensed and the user 10 (Fig. 3A, 5A) is inhaled, the portions 52a-f of the diaphragm 52 are flexed and separated in the direction of the opening 50 to permit the The dose travels through the opening 44 through the chamber 44 to the user 10. Referring now to Figure 7B, in accordance with one aspect of the present invention, the apparatus 3, 25, 30 (as described above with respect to Figures 1A-6B) includes beam sensors 54a and 54b disposed between the diaphragm 52 and the opening 50. . As shown, the diaphragm portions 52a, 52b, and 52c are warped to allow the dose to pass from the chamber 44 to the user 10 via the opening 50 (as indicated by the direction of the arrow) (Fig. At 3A, 5A), the beam 56 between the inductors 54a and 54b is interrupted. The interruption or destruction of the beam 56 is caused by the portions 52a-f of the diaphragm. This event is an indication of the dose inhaled by the user 10 and the sensors 54a and 54b delivering a signal to the control unit 36 of the device 3, 25, 30. The control unit 36 is thus capable of encoding the information in the current flow or transmitting the information to the detector 20 and thereby confirming that the dose is delivered to the user 10. According to another aspect of the invention, the chamber 44 can also include an optical gap 58 before the diaphragm 52. In the optical gap, at least one optical sensor 60 is positioned to detect light emissions originating from a light source 62, such as a light emitting diode (LED), also included in the optical gap. When the dose is released into the optical gap of the chamber 44, the optical sensor 60 detects a decrease in light intensity due to the presence of a dose which is a powdery opaque substance. The optical sensor 60 is electrically coupled to the control unit

S 32 201208643 36. Upon detecting a change in light intensity, the optical sensor 60 signals the control unit 36 to indicate the presence of the dose. Referring now to Figure 7C, in accordance with one aspect of the present invention, the apparatus 3, 25, 30 (as described above in relation to Figures 1A-6B) includes impedance measuring units 58a and 58b disposed in the diaphragm 52 and the opening 50. between. In the closed position, the diaphragm 52 has a unique impedance when contacted with the portions 52a-f, as measured by the impedance measuring units 58a and 58b. Once the diaphragm portions 52a-f are fixed and separated, the impedance characteristics and changes of the diaphragm. As shown, the diaphragm portions 52a, 52b, and 52c are secured to permit passage of the dose from the chamber 44 through the opening 50 to the user 1 (as indicated by the direction of the arrow) (Fig. When ΙΑ, 3A, 5A), the movement of the diaphragm portions 52a, 52b, and 52c causes a change in the impedance of the diaphragm 52. This change in impedance is detected by the impedance measuring units 58a and 58b and communicates with or signals the control unit 36 of the device 3, 25, 30. The control unit 36 is thus capable of encoding or transmitting this information to the detector 20 and thereby confirming that the dose is delivered to the user 10. According to another aspect of the invention, the apparatus 20 includes a capacitive haptic sensor control unit (not shown). Once the device 20 is in contact with the user's hand and mouth, the control unit 36 receives a signal originating from the sensor control unit and the control module activates a chamber control unit. The chamber control unit begins dispensing the dose. According to one aspect of the invention, the device 20 continues to dispense the inhalable to the user 10 (Fig. 3A, 5A) such that the device 20 delivers a continuous dose. According to another aspect of the invention 33 201208643, the device 20 delivers a single dose. Once the sensor controls the single f detection and no longer contacts the user's mouth or hand, the sensor control unit sends a stop or second signal to the control unit. The control unit 36 sequentially sends a signal to the chamber control unit for dispensing the dose 〇 - the Γ 11 2G includes - the processing unit, the system configuration portion is exposed thereto, the second unit is coupled to the processing unit 7 (4) The f 76 is wound around the outer casing 72 and electrically coupled to the detector 20 to include two lightning poles. In the case of the subject, the detection, according to another aspect of the present invention, does not limit i to include fewer or more electrodes in the disk, and the scope of the present invention is fine. 2〇 The number of associated electrodes. Thus, in a multi-electrode (such as two or more electrodes, the detector 2G includes one or more electrodes) for detecting electrodes and/or including complex pairs by a thief

The description passes through the use of ^ 5, 3G (such as the above related to the Figure 1A_7C 槿 Φ * dip the body current signal of the messenger. At the attention of a 20 t t μ and distance from the valley to the electrode detection - differential Voltage (differential ::::^ does not = from I5 to 2.5 cm. The detector 20 can include a complex number of parts and processing protocols. In addition, the detector Θ U ^ ^ ΐ 0I external or portable For example, in the February 2nd, February, the gangsters of the United States, the real-life beer-seeking application No. 12/564,017, the standard 34 201208643 is disclosed in the body-integrated receiver and method, and The disclosure of which is hereby incorporated by reference in its entirety herein in its entirety in its entirety in its entirety in its entirety in the the the the the the the the the the the the the The detected voltage, which represents the current characteristic, is delivered via line 82 to amplifier 80, which is electrically coupled to the electrodes 74 via the amplifier 80. The detected current characteristics are thus placed in the demodulator 84. Simultaneously displaying a memory unit 85 coupled to the demodulator 84, one The clock 86 and a transceiver unit 89. The memory unit 85 is capable of storing information including information associated with the dose delivered to the user 10, and delivering the dose to the user 10 or by the user 10 The physiological state of the user changes after inhalation. The clock 86 provides timing information and writes to the memory unit 85 in order to leave a time stamp for the events recorded in the memory unit 85. The transceiver Unit 89 transfers the data from the memory unit 85 to an external data processor unit, not shown. For example, the transceiver unit 89 can receive information from an external device or directly via internet communication for collection. The information related to environmental parameters and the provision of specific information include physiological parameters related to the patient; changes in heart rate, body temperature, respiratory rate, and physical activity, duration and timing; timing of dose delivery The frequency of dose delivery; and the change in physiological parameters that sense the delivery of the dose to indicate a potential event (eg, an incident or episode) The detection. Therefore, the detector 20 can provide information via wireless communications to automatically detect prior to delivery of adverse events and reactions to medicine after delivery. Furthermore, the investigation

S 35 201208643 The detector 20 is capable of using environmental parameters, such as the number of pollen floating in the air or the degree of air pollution, to provide the user with specific information regarding the likelihood of an event that may occur. Furthermore, the detector 20 is capable of recording and providing reference data associated with the user 10. For example, using a reference to heart rate and breathing relative to the extent of physical activity, if there is limited or no physical activity, that is, a high breathing rate, it is possible to detect the onset of the disease. The processing unit 70 also includes a power source 87 that is electrically coupled to a microprocessor 88. The microprocessor 88 is electrically coupled to all components and coordinates the functions between the different functional blocks and power management. In accordance with another aspect of the present invention, the components of the processing unit 70, including the microprocessor 88, are connectable to a busbar and are thereby electrically interconnected to each other and controlled by the microprocessor. According to other aspects of the present invention, the entire system includes the detector 20 and the devices 3, 25, 30 (as described above in relation to Figures 1A-7C) communicating and separately recording associated dose delivery to the user. Part of the event. For example, as shown in FIG. 9, the processing unit 70 includes a module 90. The detector 20 can be used to detect the inhalation action by the detector 20 disposed closest to the lungs of the user's body. The module 90 is an accelerometer and records the event. According to another aspect of the present invention, the processing unit 70 of the detector 20 is configured as a sound detector. The sound detector 90 detects sound associated with the user 10's deep breathing. According to another aspect of the present invention, the sound detector 90 also detects the sound unit 33 of FIG. 4C or

S 36 201208643 The acoustic or acoustic signal produced by the sound unit 31 of Fig. 5E. If the detector 20 has detected originating from the device 3, 25, 30 (as described above in relation to Figures 1A-7C and thereafter related to Figures 400A-B, 400, 500, 600, 700) The presence of a current flow, and recording the sound associated with the inhalation, and/or the sound produced by the sound unit 33 of FIG. 4C or the sound unit 31 of FIG. 5E associated with loading the dose, then the sound detection The detector 90 will record the inhalation event as a representation of the dose delivered to the patient. According to another aspect of the invention, the processing unit 70 is coupled to the module 90 including an optical detector. The optical detector of the module 90 will be positioned within the detector 20 such that a portion of the housing will be transparent and a light beam is received into the optical detection unit 90. According to another aspect of the present invention, the processor 70 of the detector 20 can include any combination of the accelerometer, the sound detector, and the optical detector. In accordance with various aspects of the present invention, the system of the present invention can include a single detector or a complex detector. In the case of a system including a single detector, the detector can include three or more individual electrodes and can be configured to be disposed in an abdomen or xiphoid region of the user. The detectors of such systems can be deployed at any convenient location, such as the front of the torso, the back of the torso, and the like, if desired. In systems with multiple detectors, each receiver can have a single detector and the receivers can be interconnected to produce an array of detectors. According to another aspect of the present invention, the sound detector and the current flow 37 201208643 can be detected in the device 3, 25, 30 (as described above in relation to Figures 1A-7C) and the current flows and The presence of both of the acoustic vibrations will mean that the device is maintained in position by the user 1 (Figs. 1A, 3A, 5A) and the dose has been filled into the chamber. According to another aspect of the present invention, a mechanical switch can be used to generate an activation signal from a mechanical action that is triggered when the dose is loaded into the chamber or via a mechanical motion required by the inhaler. This dose delivery is provided. Referring now to Figure 10, the user 10 configures the device 3, 25, 30 (as described with respect to Figures 3, 3A, 5A) to his or her mouth and inhales. According to another aspect of the invention, the device 3, 25, 30 defines an aperture 310. When the user 10 is inhaled through the mouthpiece 320 of the device 3, 25, 30, the airflow through the aperture 310 produces a sound similar to that produced by a female. The acoustic waves generated by the device 3, 25, 30 travel through the surrounding air and into the lungs of the user 10. The sound waves enter the lungs of the user 10 and travel through the body of the user. The detector 20 is secured to the user 10 and includes a sound detector that detects sound waves traveling through the air and through the body of the user 10. Thus, when the user 10 inhales, the sound waves generated by the orifices 310 of the devices 3, 25, 30 can be detected and associated with the event associated with delivering the dose to the user 10. The detection of the sound wave via the combination of air and tissue of the user confirms that the user 10 is inhaling and receiving the dose via the device 3, 25, 30. Furthermore, in accordance with another aspect of the present invention, the aperture 310 of the device 3, 25, 30 can be adjusted to produce a particular or unique

S 201208643 Frequency, which is further used to confirm that the user 10 is inhaled via the device 3, 25, 30 as intended. According to another aspect of the present invention, a detector 210 can be used in the form of a watch worn on the wrist of the user 10. According to another aspect of the present invention, the detector can be transplanted and can communicate with a detector located outside the body of the user. As such, sound waves traveling through the body of the user can be detected and correlated with sound waves traveling outside the body of the user. Referring now to Figure 11, in accordance with another aspect of the present invention, an access device 100 is shown having a needle portion 102 and a data collection module 104. The access device 100 defines an access or opening 106. A user or a patient who is in the hospital or outside the hospital is very often associated with an access device 100, such as the access device 100, which is configured for the duration of the user from hours to days, weeks Or even months. The access device 100 is used in a variety of applications, including the introduction and removal of fluids from the body. The access device 100 can be used to inject or inject medicine and essential fluids, as well as to remove fluids such as blood and feces. Typical examples of an access device 100 include: catheter (intravenous, urinary, etc.), IV access, artificial tube, and the like. For all of these devices, there is a high degree of infection due to general use and cleaning. Properly maintaining the access device 100 includes properly cleaning and disinfecting the device port prior to use, particularly for the access device 100 that remains in place for more than a single use. In its most basic form, the cleaning operation involves inserting a syringe or other device 39 201208643 into the entrance and exit (10) of the entrance and exit (10), wiping the service as an alcohol-based bactericide, including the correct technology. A good collection module 104 with each of the (four) flowers is combined with the needle portion. The detector 20 can be by the side of the data === = the side of the user's body or the sensor that is connected to ==. The information can be communicated to the detector using any of the disclosed m-comp., including (4) changing the carrier. According to a different point of view of the present invention, the data collection module ι 4 can be added to the exit device UK as an add-on or a redesigned entrance and exit to track the maintenance of the port. For example, it is possible to detect the time spent in contact with the edge of the population and thus the cleaning of the entrance 106, including the amount of time it takes to record the wipe and dry the outlet 106. Further, the time at which the sigma can be recorded by the syringe or other device and the total time the syringe spends in the port 106 can be recorded. The collection of this information can be used to show that the maintenance of the entrance and exit 1〇6 has been completed correctly and in the correct order, and is completed by the mother and child, as revealed in the publication of δ on August 25, 1st. C. US Provisional Patent Application No. 61 / 377 072 'System and Method for Patient Outlet Reports (System)

And method for patient ACCESS PORT REPORTING), which is incorporated herein by reference in its entirety for reference. 201208643 In accordance with various aspects of the present invention, the data collection module 104 senses cleaning or wiping operations of the access 106 using a plurality of methods, including impedance measurements, sound measurements, and pressure measurements. For example, impedance measurements are accomplished by first measuring the impedance of the presence of no conductive fluid between the electrodes of the inlet and outlet 106, such as the presence of alcohol. When the inlet and outlet are cleaned by alcohol or a similarly conductive fluid, the impedance between the electrodes is changed by the alcohol or the disinfecting wipe, and the change in impedance and the timing of recording the change can be measured. When the alcohol evaporates and the wiping action ends, the impedance returns to the previous level. According to another aspect of the present invention, a sound detecting device can be used to detect a signal or vibration associated with the wiping action. In addition, the data collection module 104 is capable of detecting the pressure associated with the wipe action at the entrance 106. The access device 100 is electrically coupled to the patient to allow communication of the information with the detector using the change in the current signal. According to a different aspect of the present invention, the electrical connection between the access device 100 for communication between the data collection module 104 and the detector 20 worn by the user is in the form of a plurality of It is done mechanically, including conductive tape, conductive or in-line conductors. According to another aspect of the present invention, the communication connection between the detector 20 worn by the user and the data collection module 104 of the access device 100 can be via the use of a tube wall or the use of a fluid in the tube. As a capacitive conduction of the conductor. According to other aspects of the present invention, an inductor located on the access device 100 can be used to confirm proper operation or maintenance of the access device 100, and to activate the data collection module 104 to document the cleaning operation and the access. Use of device 100. For example, the device can be designed to verify that the nurse uses gloves when handling and accessing the mouth. According to another aspect of the present invention, the data collection module 104 can also be used to measure local skin/body temperature and provide a signal to the detector via its contact with the user to alert the infection. The view of the portable version of the detector can have a sealed and biologically compatible chamber defined as a closed region, such as ChipskinTM technology, one or more sensing electrodes, a power source, It can be a primary battery or a rechargeable battery, or can be powered by inductively broadcasting to a coil. In the case of an external signal receiver, the appearance includes a structure having electrodes in contact with the skin of the user. The communication can be performed wirelessly or by one or more conductive media, such as wires, fibers, and the like. The same electrodes can be used to receive and transmit signals where needed. Having described the different perspectives of a medical delivery system for delivering an inhalable dose, it will now turn to a different additional point of view for a medical delivery system that is generally used to deliver pharmaceutical products in the plural. In various aspects, the medical delivery systems can be designed and configured to deliver a medical product in the form of a digestible product, such as, for example, a pill, a tablet, a sublingual tablet, a polymer decomposition. Ingot, a capsule, a latex capsule, a sustained release oral dose, a suppository, a liquid, a liquid capsule, a pill, a pill (soluble or otherwise), or a capsule-bound liquid, one in the other Forms of medicine include pills, tablets (soluble or otherwise), capsules, liquids, and blister packs of latex. Different views

S 42 201208643 'The medicine may include ingestible devices such as, for example, ingestible event markers (IEMs), as disclosed in the U.S. Patent Application Serial No. 12/564,017 filed on Sep. 21, 2009. The communication system of the power supply is not disclosed and is disclosed in US 2010/0081894, the entire disclosure of which is incorporated herein by reference. In another example, the medicine can include a camera device that includes a radio frequency identification (RFID) function, such as an active rfid device or a passive RFID device. Depending on the particular configuration, the medicine can be sealed or opened. However, the scope of this disclosure is not limited by the shape or type of the product. An ingestible product, together with the phrase "ingested or ingest or ingesting", is understood to mean any introduction of the product into the body and may include oral, anal, vaginal introduction or any introduction of the product. A natural body orifice. Referring now to Figure 12A', the user 10 is shown wearing a detector 2 and physically contacting a device 400. The device 400 is configured to be delivered as a pill. Medicine in the form of a tablet or capsule (pill). The detector 20 is shown at a location on the body of the user and is communicatively coupled to the user and is capable of detecting The current flow of the user's body. However, the scope of the different aspects of the present invention is not limited to positioning the detector 20 on the user's body. The detector 2 can be fixed to the user's body. According to another aspect of the present invention, the detector 20 is fixed to the user's clothes. According to another aspect of the present invention, the detector 20 can be jeweled, watched, or worn by a user. In such a manner, the detector 20 can be communicatively coupled to the user, for example, in contact with the user, closest to the user's body 43 201208643, and most in communication with the user. Proximity, etc. In one aspect, the detector 20 can be disposed on the user's body to detect muscle movement associated with the user's 10 swallowed dose. Depending on the location and in the location The position of the electrode or the contact area of the user's body is considered, and an additional swallow detection technique is considered. As explained above, the detector 20 is a detector located outside the user. In another aspect, the detector 20 can be positioned or implanted within the user, particularly in relation to tongue movement associated with swallowing motion. For example, during a swallowing motion, the tongue moves upward toward the upper jaw. Therefore, the detector 20 or the contact area connected to the detector can be positioned to detect the movement to confirm the swallowing action. In another aspect of the present invention, the detector 20 can Partial planting In the body of the user, the in vitro robust detector 20 of the present invention includes such devices that are suitably sized and stably coupled to a living body in a manner that does not substantially impinge upon movement of the living body. For its part, the detector 20 can have dimensions that, when secured to the user 10, will not cause the user 10 to experience any differences in comfort, mobility or movement. Figure 12B One aspect of the medical delivery device 400 is shown for delivering a single pill from a pill reservoir. The device 400 includes a housing 402 having a chamber 404 (reservoir or container) portion for storing a plurality of A single pill 406, and a delivery tube 408 or device are used to deliver a single pill dose 406a. The user 10 holds the device 400 in its hand and places the device 400 at its mouth to contact the device 400 at at least two locations. The user 10 then activates a pill delivery mechanism for 201208643 to deliver a prescribed pill dose 406a into the delivery tube 408. Although the device 400 is shown to deliver a single dose of 4〇6a, the device can be designed or configured to deliver a plurality of pill doses according to a prescription medication. For young children, the parent can hold the device 400. In different perspectives, if the child is in contact with the parent, follow the instructions below to complete a circuit through the parents and the child. To clearly illustrate its functionality and the components therein, the device 400 is shown in block diagram form. However, according to the different viewpoints of the present invention, the device 400 can be constructed in a plural shape. For example, in one aspect, the device 400 can be designed or configured to deliver a suppository in the rectum of the user. Therefore, the detector 2 can be configured in a manner to detect the delivery of the actual suppository dose. Figure 12C illustrates an aspect of the medical delivery device 400 for delivering a single pill from a pill reservoir. The device 400 illustrated in Figure 12C includes a housing 402 having a chamber 404 (reservoir or container) portion for storing a plurality of individual pills 406, and a delivery tube 408 or device for A single pill dose 406a is delivered. The device 400 further includes an actuator 410 operatively coupled to a pill valve 416 port or a latch mechanism for controlling delivery of the single pill dose 406a via the pill valve 416, which may be electrically, mechanically Or act mechanically. In a different opinion, the actuator 410 can include a mechanical button, lever or magazine with the port 416 such that the user contacts the actuator to cause the valve 416 to deliver the single drug nine dose 406a. In other aspects, the actuator can include an electromechanical or electrical button or switch that is electronically coupled to the electric pill valve 416 to cause contact with the actuator 410. 201202643 Bioelectronic control (four) σ 416 or the position of the flash lock to deliver the single pill dose of 4 嶋. Mechanical, electrical, electronic and/or electromechanical actuation mechanisms can be considered, and the other and/or four (4) mechanisms are used to precisely control the delivery of the pill dose, usually as a pill, but can be configured It is also possible to control the delivery of a plurality of pill doses. Also shown in Figure UC is at least two contact regions 412 and 414 that are electrically coupled to the device 2G via the user's body. The user 1 holds the device 40"G in its hand and places the device_ to the user's mouth so that the first contact 412 is in contact with the user's mouth and the first contact 4M The user's hand contacts, thereby contacting the device shed at at least the position 'as shown. The user 1() then initiates a pill delivery to deliver a prescription or a predetermined pill dose 槪a into the delivery tube 408. 13 Thus, as explained above, the at least two contact regions 412, 414 are Connected to a power source such that when the user is in contact with each of the two contact regions 412 414, a circuit and a current path are completed and detected by the detector 2 coupled to the user 10 A current flows. Figure 12D illustrates one aspect of the medical delivery device 4 for delivering a single pill from one of the individual sealed pills. The device 400 illustrated in Figure 12D includes a housing 402 having a chamber 404 (reservoir or container) portion for storing a plurality of individually sealed pellets 406 in a sealed package 418 (for clarity) In the dotted line, a delivery tube 408 or device is used to deliver a single pill dose 406a. The device 400 further includes an electric pill valve 420 that, when activated by an actuator mechanism 410 (not shown) as illustrated in relation to Figure 12C, is an electric pill

S 46 201208643 Single-pill dose 4Q6a delivery, and at the same time the pellet 4 is sent before the single "two packs two: into the delivery tube 408. Take out from the haique seal package 418. The seal of the seven 酤 j 封 pills 406 is kept in any need. ^ will be a plurality of individual jintian (four) ^%, such as a dry and sealed heart to keep Le Yang Yang fresh and able to reduce the need for refrigeration lowest. In other respects, the outer shell, and more specifically the chamber, may be so tight that it is only opened during the delivery of the single-pill dose 4· and the other pills remain sealed while the other pills remain sealed. Also shown in Fig. 12D is at least two contact regions 412 and 414 that are responsive to the detected H 2G by the user's body. The money user ι〇, will hold the device 其 in its hand and place the device _ to the mouth of the user such that the first contact 412 is in contact with the user and the first contact 414 Contact with the user's hand, thereby at least two contacts with the device, as shown. The user then initiates a pill delivery prescription or a pill dose (10) to be delivered into the transfusion 414em. Thus, as explained above, the at least two contact regions 412, ^ are connected to - (four) minus t whip users and When the light is 2, 414, a circuit and a 1 flow path are completed, and the detector 20 of the user handles the flow of the spider. See Figure 13Α' to show that the user is wearing a 〇2〇 and a device _ for the body. The device 5 is loaded into a sealed bag of tape, which is a pill, a tablet or a capsule (medicine===4). The 2G system shows that h is placed on the user's body and is in communication with The user can illuminate the vehicle and, as explained on 201208643, can detect the flow of current through the body of the user. Figure 13B illustrates one of the points of the medical delivery device 500 for sealing by a plurality of A single pill is rotated in a strip 504 of the pill. The device 500 includes a housing 502' that defines a chamber 510 for holding a tape 504 containing a plurality of sealed pellets. The pill is removed from the tape 504 as described below, and the pill delivery tube 508 delivers a single pill dose to the user 10. As shown in Figure 13C, for example, the tape 504 can comprise a plurality of seals. A plurality of pills 506' in a package can be reeled and inserted into the chamber 510. The device 500 can use a plurality of advanced mechanisms for delivering a single dose or multiple doses according to a prescription medical plan. Use 10 holding the device 500 in its hand and placing the device 5 at its mouth to contact the device 500 at at least two locations. The user 10 then activates a knife and scroll transport mechanism for A prescription or a predetermined dose of the pill is delivered into the delivery tube 508. In the case of a young child, the parent can hold the device 500. In different perspectives, if the child is in contact with the parent, as described below, via the parent and The child completes a circuit. The device 500 is shown in block diagram form in order to clearly illustrate its functionality and its components. However, in accordance with various aspects of the present invention, the device 5 can be constructed in a plurality of shapes. • Figure 6 is a view of a 6th medical delivery device for transporting a single pill from a strip of adhesive 5〇4 containing a plurality of pills sealed therein. The device illustrated in Figure 13D 5〇〇 relative to the user 1〇, a knife 512 is arranged at one end portion of the conveying pipe 5〇8.

S 48 201208643 The knife 512 is configured to peel the pill 506 from the tape 504 when the tape 504 is mechanically advanced to deliver the correct pill dose to the user 10. Other mechanical means can be used to break the package of the tape 504 and release the pill 506. In one aspect, the package roll and knife 512 mechanism can be electronically interlocked to prevent excessive dose. In the point of view, the end of the tape indicator 514 is shown when the medical system is near completion and/or when a recorder date is expired. It should be noted that the medical delivery configuration of the tape is not limited to maintaining a pill. As shown in Figs. 13E and 13F, for example, Fig. 13 is a plan view and Fig. 13F is a side view of a tape 522 transport mechanism for transporting liquid medicine. As shown in Figures 13E, 13F, the tape appears to include an individually sealed pouch 524. Each bag of liquid medical dose 526 is sealed within the pouches 524, and each bag filled with liquid medicine 526 is individually sealed and attached to a common tape 522 for delivery. A mechanical device 'such as the knife Sl2 (Fig. 13D) breaks the pouch 5 body medicine 526 via the wheel to send the kite θ 甘 from the ^ 508 or other mechanism to the user 1U.

In one point of view, 'in Figures 13A, 13c, and 13D, the gentleman's 丨V is about 日 久 久 久 久 UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD UD Soluble pharmaceutical dosages. Therefore, when the tool advances, the knife Sl2 ▼ is used to separate the medicine dose from the package, although it is not explicitly displayed, but it should be understood in order to reveal the clarity of the Α Α # ^ # The device shown in Figures BA and 13D and related to the drawings is described in the description of the Japanese Patent Application No. 49 201208643. . The contact field is electrically coupled to the a-detection state 20 via the user's body. For example, the user can be coupled with the capacitive region of the user. Therefore, the dielectric material can be coated in a little area, such as ^===; the capacitive communication is completed to complete the electrical communication: if the === electrical material is covered, the device and the user can be inside the electrode Embedded in the plastic material, there is a state--^^2胗柯枓中 and the use of capacitive coupling and the two-dimensional m ^ port and the two plates are in contact with the two plates when the impedance of the two capacitors is intertwined to sense the user The existence of the mouth. The capacitive coupling can be done at a signal frequency greater than about 2·ζ and in some respects about 80 kHz is good for the signal-to-noise ratio (SNR, for example, signal and ambient noise). Holding the 5 hai device 5 〇〇 in its hand and placing the device 500 to its mouth' so that a first contact area contacts the user's mouth and a second contact area and the user The hand is in contact, thus contacting the device 500 to: > at a location as shown. The user 1 splicing a roll and knife transport mechanism to deliver a prescribed or predetermined pill dose to the delivery tube 508. Therefore, as explained above, the at least two contact regions are connected to a power source such that when the user contacts each of the two contact regions, a circuit and a current path are completed, and by using the same The 10 coupled detector 20 detects a current flow. Referring now to Figure 14A, the user 1 is shown wearing a detector 2 and in physical contact with a device 600. The device 600 is configured to circulate a liquid contained in a sealed tape roll package and a medicine in the form of a combination of a pill, a tablet or a gel 50 201208643 capsule (pill). The detector 2 is displayed at a position fixed on the user's body and is communicatively coupled to the user 1 and is capable of detecting a current flow through the user's body, as explained above. . Figure 14B illustrates a point of view of the medical delivery device 600 for delivering a single pill from a tape 6〇4 in which a plurality of pills are sealed, and capable of delivering a dose of liquid 614. The liquid 614 can be a water or liquid medicine. In the opinion, the liquid 614 can be a two-component liquid medicine in which a therapeutic molecule is produced or activated by reaction and/or control in the living body = local pH when the medicine is delivered. The device 6 includes a shell 602' defining a -th chamber (10) for holding a tape 604 containing a plurality of pills, and a second chamber 6 6 being separated by a wall 612. The second chamber 606 holds the liquid 614. Once a plurality of techniques have been used, for example, as described below, the drug is removed from the tape 6〇4, i.e., the delivery is combined with the liquid 614 to the user H). The tape 604 can comprise a plurality of plural pills sealed in two:: which can be coiled and inserted into the chamber 61. The use of a plurality of advanced mechanisms can be used to draw according to the prescription medicine Transport one dose a day or multiple doses. As far as young children are concerned, Sun Wei. The device 600 is held. The user 1 holds the device 6 于 grip and holds the device _ to its σ to contact the u = - position. For different wealth, if the child is 乂, as described below, through the parents and children to complete the H ’ description of its squad and its components, it is difficult to set _ such as ^ ^ 51 201208643 style display. However, the device 600 can be constructed in a plurality of shapes in accordance with various aspects of the present invention. Although not explicitly shown, in order to reveal the clarity of the content, it should be understood that the apparatus 600 shown in Figures 14A and 14B and described in relation to the figures includes at least two contact areas via which The body of the person is electrically coupled to the detector 20. The user 10 holds the device 600 in its hand and positions the device 600 to its mouth, thereby bringing a first contact area into contact with the user's mouth and a second contact area and the use. The hand is in contact and thus contacts the device 600 at least at two locations, as shown. The user 10 then activates a roll of package and knife transport mechanism to deliver a prescribed or predetermined dose of the pill into the delivery tube 608 and can then tilt the outer casing 602 to release a dose of the liquid 614 to swallow the pill. dose. Therefore, as explained above, the at least two contact regions are connected to a power source such that when the user contacts each of the two contact regions, a circuit and a current path are completed, and by using The 10 coupled detector 20 detects a current flow. Referring now to Figure 15A, the user 10 is shown wearing a detector 20 for physical contact with a device 700. Device 700 is configured to deliver a medicament in a combination of a liquid contained in a sealed tape roll package and a pill, tablet or capsule (pill). The detector 20 is shown in a position fixed to the user's body and is communicatively coupled to the user 10 and is capable of detecting a flow of current through the body of the user, as explained above. Figure 15B illustrates the medical delivery device 700 for use by a pocket 716 (eg

S 52 201208643 A different dose of liquid medicine 704 is delivered as in a flexible pouch, bag, or the like. The fistula device 7A includes a housing 7〇2 that defines a chamber 71 for holding the pouch 716 filled with the liquid medicine 7〇4. A pressurizing mechanism 7〇6 pressurizes the bladder 716 with a predetermined amount for delivering a corresponding dose of the liquid medicine 7〇4 to the delivery tube 7〇8 via the flow valve 712. The pressurizing mechanism 7〇6 may comprise a hydraulic, pneumatic, mechanical, piston, stepper motor, servo motor or any other suitable mechanism for applying pressure to the portion of the pocket 716 in order to force a correspondence The dose of liquid medicine 704 flows into the wheel tube 708. In one aspect, as shown, the pressurizing mechanism includes a movable piston 720 coupled to a movable plate 718. The piston 720 advances the slab 718 for application to the outer portion of the pocket 716 and retracts the plate 718 for removal of pressure therefrom. The piston 720 can be hydraulically, pneumatically, mechanically, electromechanically, electronically, by a stepper motor, or by a servo motor. The piston 720 can be replaced by a lead screw that is coupled to a motor (stepper or servo motor) for propelling or retracting the plate 718. The pressurizing mechanism 706 can be coupled to a mechanical or electrical actuator. The user 10 holds the device 700 in its hand and places the delivery tube 708 of the device 700 to the user's mouth, thereby causing the device 700 to contact at at least two locations. The user 10 then activates an actuator to deliver a prescription or predetermined dose of liquid medication 704 into the delivery tube 708. The user then draws liquid into his or her mouth. During the inhalation action, air enters through the vent 714 and is introduced into the delivery tube 708 after the liquid medication 704 to force the liquid medication 704 into the mouth of the user. In different perspectives, if the child is in contact with the parent, 53 201208643 completes the circuit via the parent and child as explained below. To clearly illustrate the functionality of the device and the components therein, the device 700 is shown in block diagram form. However, the device 700 can be constructed in a variety of shapes in accordance with various aspects of the present invention. "Although not explicitly shown", in order to reveal the clarity of the content, it should be understood that the device 700 shown in Figures 15A and 15A and described in relation to the drawings includes at least two contact regions 'and via The user's body is electrically coupled to the detector 20. The user 1 holds the device 7 in its hand and places the device 700 at its mouth: 彳^使—contact area and The user's mouth contact and the second contact area user's hand contact, so contact with the installation i 500 1 at two locations: as shown. Therefore 'as explained above' the at least two contacts The area is connected to a power source such that when the user contacts each of the two contact areas, a circuit and a current path are completed and detected by the detector 20 coupled to the user = The current flows. The devices 400, 500, 600, 700 shown in Figures 12A-15B and described in relation to the figures may include a power source as shown in Figures 2A and 2B and described in relation to the figures. 34. A control unit 36, contact areas 38, 40, and a memory list Element 42. According to the above-described point of view, the individual devices 400, 500, 600, 700 include at least two contact regions/points 38, 40 (corresponding to the contact regions 412, 414 in Figures 12C, 12D) Different locations on the outer casing. The locations and designs of the contacts 38, 40 or regions are determined by the shape and design of the device 3 and from the different perspectives of the present invention. For the contact regions 38, 40, Can consider plural

S 54 201208643 Location. According to another aspect of the present invention, the contact regions 38, 4 (corresponding to the contact regions 412, 414 in Figures 12C, 12D) may include consideration of biometric authentication information, such as reading and recording of fingerprint data. Feature. This $ can be communicated to the device 400, 500, 600, 700 and stored therein for the identity of the user to confirm. The contact regions 38, 40 (corresponding to the contact regions 412, 414 in Figures 12C'12D) are electrically isolated from each other and are at least partially exposed or exposed to allow the user 1 to contact. According to one aspect of the invention, the contact regions 38, 40 are positioned such that a contact region 38, for example, is in contact with the user's hand and another contact region 40, for example, in contact with the user's mouth. . According to an optional aspect of the present invention, an additional area can be added to take into account a second contact with the hand or mouth and to use a different hand-negative 'such as a left-handed grip or a right-handed grip Grab. Further, additional contact areas on the outer casings 402, 502, 602, 702 can be included to ensure that the devices 400, 500, 600, 700 are properly held. The device 400, 500, 600, 700 shown in Figures 12A-15B and associated with the drawings may include one or more sensors for detecting the single-dose pill 406a input to the user ! The mouth of the mouth. For example, in addition to the other sensors discussed above, the sensor may include detecting liquid, saliva, moisture, coloration changes when the pill is in place, vacuum pressure, conductivity, sound. In addition to the types of other non-contact sensors, the sensors can be packaged with (4) plus contact areas for the capacitive axis to detect the user and device 働 _, the electric _ 躲 非 非 最 最 最 最Let 55 201208643 users measure the debt except for other positions' by appropriately arranging at the different positions on the body of the braided electrode (for example, the contact area) swollen, neck 1G 'such as torso, chest With swallowing. Swallow action: 1 颚 而 而 ❹ _ action, used for price measurement - electronic cans? Joint muscle exercise. In other points of view, equipped with electrodes 四 (4) thieves can be used to detect the delivery of a pill 4 4 〇 6a or swallow: Li Xian:: 4 〇. As discussed above, for example, it is also possible to detect the sound emitted during the swallowing action using a suitable nickname. In other views, DNA detection techniques, such as optical DNA detection, can also be used to detect delivery of the single bolus dose 406a to the user 10 . Among the different winding points, the devices 400, 500, 600, 700 shown in Figures 12A-15B and described in relation to the figures may include mechanical, electronic, and/or electromechanical controls only The medicine is "delivered at the prescribed time" and only a prescribed amount is delivered to prevent overdosing. For example, a latching mechanism can be combined with the medical delivery device 400, 500, 600, 700 to prevent the user from intruding into the housing for obtaining the medication outside of a specified period of time after a correct dose has been delivered. For example, a pill delivered only in the morning cannot be dispensed in the afternoon and the user cannot invade the outer casing or otherwise enter the chamber, pill storage or reservoir to obtain the medicine. In such a view, when an IEM is delivered by the medical delivery devices 400, 500, 600, 700 shown in Figures 12A-15B and described in relation to the figures, the iem generates its own power and Connected to the detector 20 (eg, maps, 3A, 3E, 5A, 10, 12A, 13A, 14A, 15A)

S 56 201208643 Passing changes in the characteristics of the current flow by changing the conductivity. The characteristics of such changes include information encoded in the current flow, as disclosed in U.S. Patent Application Serial No. 12/564, filed on Sep. 21, 2009, which is incorporated herein by reference. The application is disclosed in US 2010/0081894, the entire disclosure of which is incorporated herein by reference. The encoded information is thus detected and decoded by the detector 2A. In addition, U.S. Patent Application Serial No. 11/912,475, filed on Apr. 28, 2006, the disclosure of which is incorporated herein in Incorporating this case into a reference. Thus, in one aspect, the medical delivery devices 400, 500, 600, 700 shown in Figures 12A-15B and described in relation to the figures are configured to deliver an IEM system for indicating an event. The occurrence, such as indicating that a medical dose has been swallowed by the user 10. In one aspect, the system is used in conjunction with a conductive fluid to indicate an event marked by contact between the conductive fluid and the IEM system. For example, the IEM system can be used with a pharmaceutical product, and the event indicated is when the product is taken or swallowed, and the IEM system is directed to an environment containing a conductive fluid. The device is in contact with the conductive fluid of the body when it is taken or swallowed to include the product of the IEM system. When the IEM system is in contact with the body fluid, a voltage is generated and the system is activated. A portion of the power source is provided by the device, and another portion of the power source is provided by the conductive fluid. 57 201208643 A swallowable product comprising an IEM system can be configured as an orally swallowable pharmaceutical formulation in the form of a pill or capsule. Once swallowed, the pill moves to the stomach. Upon reaching the stomach, the product comes into contact with the gastric juice and undergoes a chemical reaction with a different material in the gastric fluid, such as hydrochloric acid and other digestive agents. Although the system is discussed in relation to the medical environment, it does not limit the scope of such disclosures of the system. The ιεμ system can be used in any environment where there is or is a mixture of two or more components that produce a conductive liquid to become a conductive liquid. A pharmaceutical product can be combined with a system or an ion radiation module. The chirp system uses a potential difference to provide power and then modulate the conductivity to produce a unique and identifiable current signal. Once activated, the helium system controls conduction and current flow to generate the current. The encoded information is thus detected and decoded by the detector 20. In a particular example, the sputum system is combined with a medicinal product to activate the sputum system when swallowing the product or pill. The system controls conductivity to produce a unique current signal that is detected, thereby indicating that the 5H medical product has been taken. The crucible system includes a frame that is used as a base for the crucible system, and a plurality of components attached thereto, deposited on the frame or secured to the frame. In this view, a swallowable material is physically associated with the frame. The material may be chemically deposited on the frame, evaporated on the frame, secured to the frame or mounted on the frame. All of the ways herein are considered to be related to the frame 'deposition. The material is deposited on one side of the frame. Materials that can be used as materials of interest include, but are not limited to, Cu or Cul. In addition to other agreements,

S 58 201208643 °Hai materials are deposited by physical steaming. The thickness of the material can be increased from about 5 to about 100 microns thick from about = or electroless deposition. By reducing the cover, about 500 microns, such as from , the shape. In addition, ie, each system may contain two or more electrical "for > children's readings" in which the material may be deposited. The upper-only region, if necessary, may be eliminated: On the opposite side, for example, the deposition of the other side of the side may be limited to the side selected for the same side as the one selected, and the term "not one." The n first selects (9) different sides of the inclined side to change the liquid, such as when the body fluid contacts, the material of interest:: but not limited to::= adhere the material to The frame of the donor layer contributes to the typical adhesion of the layer of a 钭, 仏忒 (special) material: 乂, ,, or each similar material. By physical vapor deposition, "hoarding method or electrodeposition deposition method for depositing anode material and the adhesive layer. The thickness of the (ano) material may be from about 0_05 to about 5 〇〇 microns, such as thickness from spoon 5 to about 1 〇〇 micron. However, the thickness or deposition process is not limited to the point of view of the I system or any of the materials used to deposit or fix the material to the frame. 59 201208643 According to the ~ point of view, any pair of such The material may be a material having different electrochemical potentials, such as 1 or different materials, wherein the 1EM system is determined to be in the organism, and the different materials may be vitamins that can be absorbed. Any two materials. The environment in which the 1EM system operates is different. When the material is used for ingestible food, the material of the pair is "language" ~ there is Μ electric scale electricity (4) any liquid, such as gastric acid, contact Γ when the 1 ΕΜ system is associated with an ion, and is specific The specific suitable material is not limited to gold non-metal selection, such as (four) towel, the pair is made up of a pair of metal and or (d): gold ^ (such as town) and a salt (such as cuC1 for the substance - - Metal salt materials are suitable for different chemical potentials (electric Fort) and low interfacial resistance. Suitable for different viewpoints, in Figures 1Α, 3Α, 5Α 12 Α ΐ Β Β ^ 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 并 的 的 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关 相关A unit state controller, processing unit, processor, state machine communication shown in the description of the figures. The transconductance unit includes at least two contact regions electrically isolated from each other and positioned to allow Contact each contact area, and a power source. The at least one contact area Electrically coupling with one terminal of the power source and at least another contact region is electrically coupled to the other terminal of the power source. A current path is completed by the user's body, allowing the user and the two contact regions to The current flows when each contact, and the current is detected by the controller. 201208643 In one aspect, the transconductance unit further includes a control module coupled to the power source and the at least two contact regions One is electrically connected. The control module is configured to encode the information in the current flow. In one aspect, the devices 3, 25, 30, 400, 5〇〇, 6〇〇, 7 〇〇 (as described above in relation to Figures iA-7C and Figures 12A-15B) can be configured to ensure that a medical dose is delivered to a user. The device includes at least two contact regions electrically isolated from each other, and the power source includes a first terminal and a second terminal, wherein at least one contact region is electrically coupled to the first terminal and at least another contact region is coupled to the The second terminal is electrically coupled and a control module is electrically coupled between the first terminal of the power source and one of the contact regions. The control module is configured to change the conductivity of a current path generated by the user upon contact with the parent of the two contact regions. A current path is completed via the user's body when the user is in contact with each of the contact areas. This change in conductivity encodes the information in the current flow. The detectors of interest include, but are not limited to, the disclosure of PCT Application No. PCT/US2006/016370, the disclosure of which is WO 2006/116718, the disclosure of the patent application number PCT/2007/24225, which is incorporated herein by reference. The PCT application serial number PCT/US2 〇〇 8/52845, the disclosure of which is hereby incorporated by reference in its entirety in its entirety in the the the the the the the the the the the the ― According to other points of this (4), the pure may include two or more (such as three or more, including four or more cap detectors. In these systems, the two or more _11 may be suitably Arranged at any desired location on the user's body. For example, 'all body-integrated implements can be placed on the same side of the body on the 61 201208643 body, on the opposite side of the body, two:: the other torso, Or it may be configured to wait for the front and back of the specific instance towel h °. The sound unit 33 or::, from the lungs or in Figure 4C, the information system g early 31 receives the sound information, In the trunk week®, the most relevant 'so that the (four) detector system is equipped with a lion, _ 7: near the lung. In other points, with a position of (10)^, 2G can be configured on the user's body according to the User: Swallowing. Counting 90, inspecting the numbness! Another point of view, wherein the detector 2 includes an acceleration mechanism positioned to move close to the lungs to quickly attract people, so the side user holds the device ^ & ° If (4) measured 11 2G has also been indicated to be related to Figure iA-7...25, 3〇 , 4 〇 0, 500, 600, 7 〇〇 (such as the above side device 20 records ώ A. Description), a current exists, and thus the 1 memory! β 刿 detector 20 will be positioned on the user's body Allowing the most effective sputum to be at a location of the sputum action. The lung action can be used to determine the prescription dose that the user has swallowed by the medical delivery device previously described. However, the power detected by the detector 20 can be "typical" such that it only identifies the device 3, 25, 30, 400, 500, 600, 700 (as described above in relation to the figure) 1A-7C and Figures 12A-15B illustrate that the connected & the premises are the mouth and limbs of the user. In these examples, each device 3, 25, 3, 400, 5 , 600, 700 can flow the current + unique information encoding, especially if the user uses multiple devices

S 62 201208643, uniquely identifies a particular device relative to all other devices. The device 3, 25, 30, 400, 500, 600, 700 (as described above in relation to Figures 1A-7C and Figures 12A-15B) is configured to complexly different types of signals, including but not limited to Controls current signals generated by conductivity, RF signals, magnetic signals, conductive (near-field) signals, sound signals, and the like. The transmission time can vary, with the transmission time in some examples ranging from 0.1 microseconds to 48 hours or longer, including from 1 minute to 10 minutes. Depending on the known point of view, the identifier can generate a unique current signal once. Optionally, the identifier can be configured to generate a unique current signal having the same information (same signal), two or more times, wherein the collection of separate identical signals can be collectively considered a redundancy signal. In some aspects, the detector and the components and functional blocks of the device are disposed on an integrated circuit, wherein the integrated circuits include a plurality of individual functional blocks, that is, modules and at least some For example, two or more, up to and including all, the functional blocks can be configured in a single integrated circuit. By a single integrated circuit is meant to include a single circuit structure of all of the different functional blocks. As such, 'the integrated circuit is an early block integrated circuit* which is a miniaturized electronic circuit (which may include a semiconductor device, and a passive component) that has been formed on the surface of a thin substrate of a semiconductor material. on. The integrated circuits of some aspects of the present invention may be hybrid integrated circuits that are individual semiconductor components and miniaturized electronic circuits that are bonded to a substrate or circuit board. Although the foregoing invention has been described in greater detail by way of illustration and example for the purpose of clarity of understanding, the following description of the present invention in the form of a more general form. Therefore, in the - view two, the delivery. This line contains the user's light weight. «置(10)^;1 is configured to read the user and an I s & peripheral device defining a chamber for storing the agent domain, the system is disposed on the housing, and the at least two packs:: :electrical isolation 'and-power supply is fixed to the outer casing and: end and - negative phase terminal, wherein the contact zone is connected with == end_close' and at least another contact zone is associated with the negative terminal In the view, the contact regions may be exposed at least partially on the two portions. When the user and the two-contact area are in each day, the current path is flown by the reader's body wire, and the device connected by the user flows. 4 In the point of view, the '5 hai device further includes a control module, which is electrically connected between the Hai power source and the 4 to _ contact area, and the control unit is 1 ton. The self-produced output of the news. - In the view, the control module is configured to change the conductivity of the current path to encode the information in the current flow and decode the information. In the view, the device further includes a memory unit electrically connected to the hybrid module, and the information related to the user is stored and exchanged. The device further includes a transceiver electrically coupled to the control module, wherein the information is transmitted from the device and/or received to the detector in addition to the current flow.

S 64 201208643. In the view, the detector is configured to be implanted in the user's body, and the detector includes a sealed outer casing, a power source is fixed at the outer portion, and the system is electrically coupled and fixed to the power source. Within the housing, the sensing probe is secured to the housing, wherein the probe is attached to the blade to contact the user tissue. The probe is associated with the process, and the processor detects the physiology associated with the user and the current flow through the user. A memory unit is integrated with the read unit and secured within the housing to store data. The transceiver is adapted to handle theft and is fixed in the housing for receiving **** from the device and decoding the information. The skin is in the ▲ view that the detector is configured to be fixed to the user's detector comprising a housing, a power source that is electrically coupled to the housing, and two of the systems electrically coupled to the power source and secured thereto. The outer casing, at least the singularity of the cap, is exposed to the skin of the person, wherein the probe is electrically coupled to the processor, and is processed by the process 2 to correlate with the chronological _ physiological parameters and = the user's current flows, and the information is decoded, such as receiving the transmission from the device. In view of the fact, the sinker is crying, the detector includes - accelerating the start signal to the _to the read shell The acceleration is lightly coupled to the processor and the fixture, and the source is derived from the set. The second detection is 65 201208643. In one aspect, the transceiver includes an optical communication device in a light beam. Information encoding, and wherein the detector includes an optical receiver electrically coupled to the processor and secured to the housing. The optical receiver captures the beam and decodes the information. In one aspect, the transceiver provides From the detector to a data management Wireless communication of the heart. In one aspect, the transceiver provides an activation signal to the detector, and the detector further includes a sound module electrically coupled to the processor and secured to the housing. The sound module is activated by the processor to detect sound information originating from the lungs of the user when the detector receives the activation signal from the device. In one aspect, a device is provided for transporting a medical dose to a user and tracking the timing of delivering the dose. The device includes a housing defining a chamber for storing the dose, and at least two contact regions are disposed on an outer portion of the housing, wherein Contact regions are configured to contact the user and wherein the contact regions are electrically isolated from each other, and a power source is secured to the housing for providing electrical power to generate a current flow through the user's body, wherein The power supply includes two terminals and each terminal is electrically coupled to a contact area. When the user's skin contacts each of the at least two contact areas, the circuit is completed to generate The circuit causes current to flow through the body of the user. In one aspect, the apparatus further includes a control module secured to the housing and electrically coupled to each of the two contact regions. The conductivity of the current path between the two terminals for changing

S 66 201208643 The user's current flow characteristics thereby encode the information in the current flow. In one aspect, the apparatus further includes a memory module electrically coupled to the control module and secured to the housing. The memory module stores information associated with completing the circuitry through the user's body and the delivery of the dose. In one aspect, the apparatus further includes a transceiver electrically coupled to the control module and secured to the housing. The transceiver unit allows the device to transmit and/or receive information associated with delivering the dose to the user. In the mechanical point, the transceiver includes an optical transmitter module for optical communication. In one aspect, the transceiver includes a wireless transmitter module for use in 1-wire communication. In one aspect, the transceiver encodes information from the memory unit and transmits the information to a system external to the device. In one aspect, when the circuit passing through the user's body is completed, the 5H transmit and receive signals are sent to the external system, wherein the activation signal is that the user holds the device and is ready to start transporting. An indicator of the dose. - In one aspect, a method is provided for recording a time when a user takes a medical drug; =) 1 . The method includes: when the user contacts the external device of the device, the power-on module, the power module is completed in the manner of the circuit, and the current flows between the terminals of the power board group and through the body of the user, A conductive control module constituting the current characteristics of the circuit through the user's body 67 201208643 T, using a detector 4 / then passing the current characteristics of the body of the 4 user, the current The characteristics include information associated with at least one of the device and the dose, and a step of recording the delivery time of the inhalable dose. In one aspect, a device is provided for delivering a medical dose to a user and confirming delivery of the dose. Difficult to contain - the outer room (four) save the fresh, - turn the system (four) to the material charm including a positive = end and - negative phase terminal '- control module and its power supply electric handle, : sound detection (four) its _ Positioning to the housing and engaging with the control unit, the sound system 11 detects vibration, and at least two contact areas are positioned on the surface of the contact area, the contact areas are at least partially outside the outer casing The portion is exposed and the at least two contact regions are electrically isolated from each other. The at least one contact area is electrically coupled to one of the terminals of the power source, and the at least one other contact area is electrically coupled to the other terminal. When the user comes into contact with the other of the two contact areas, a current path is completed through the user's body, and the current is detected by the control module. In one aspect, the control module is electrically coupled between the power source and at least two contact regions = one of them. The control module is configured to control the conductance, and the information in the current flow is programmed. In one aspect, the control module is electrically coupled to at least two contact regions and two terminals of the power source. In one aspect, the sound detector is attached to the outside of the housing. In one aspect, the device further includes a memory unit electrically coupled to the control module for storing and transferring the dose to the user

S 68 201208643 information. In one aspect, the device is rushed to the control module, wherein the information is transmitted to the transceiver, and the device is transmitted and/or received to the outside of the device. In the point of view, the sound detection is crying----------------------------------------------------------------------------------------------- The sound detector provides a module 'and the control module. No. Yuan Control Capital 1.兮次#〆 Hai user inhales the associated sound, °2 is supplied by the sound _ to the control mode. a (4) module is provided in association with the delivery of the dose and the control module receives the - recognizer letter; 二 2, 2: the user is associated, wherein the time stamp is associated with the identifier, Port 5 confirms that the dose is delivered to the user. In the second to the middle, a device is provided for delivering a dose to a user, the timing of the delivery in the 't. The device includes a housing that is bounded to the dose, and at least two contact regions are disposed at the portion of the housing portion that is at least partially exposed to the outer portion of the housing: and at least two contacts The zones are electrically isolated from each other, and a power source is used to provide power through the body of the user - control: =,: the module is connected to the power source, and the device is in a sleep mode and the device is in the system In the unactuated state, the deafness is set; the ϋ is determined to the casing and is electrically combined with the control side, 69 201208643 wherein the sound detector detects the vibration and sends a start signal to the control module to activate the Control module. One of the doses loaded into the chamber activates the control module, and wherein when the user is in contact with each of the contact areas, 'through the user's body completes a current path indicating that the user will receive the medicine a dose. In the view, the device further includes - the memory unit is electrically coupled to the control group and is transferred to the shell. Recall the phantom_save the dose to the information associated with the user. The ruler is a retractor that includes a transmitter unit that is coupled to the control module and to the housing. The transfer component allows the device to transmit information. In the first step, Gujin Valley takes a step back and forth, including an optical detector module to deliver to the user, and (4) optical information and sound information associated with the sound vibration generated by the device suction. To confirm that the dose is delivered to the user. :: Viewing, providing a system for delivering a dose of medicine to a = and confirming the delivery of the dose. The system includes a controller, wherein the extractor is worn by the user, and the second device is provided with a housing defining a chamber for storing the dose, The housing includes a positive terminal and a negative phase terminal, and the power supply includes an isolation source to generate a wave, wherein: the group changes the isolation source to a contact point The area and the 201208643 area are capacitive coupling areas, wherein the two areas are electrically isolated from each other. An output of the isolation source is coupled to the contact region and another output of the isolation source is coupled to the capacitive coupling region. The contact area is touched by the user and the capacitive coupling region is capacitively coupled to the capacitive coupler worn by the user. A portion of the carrier path passes through the user's body using the contact area, and a portion of the carrier path uses capacitive between the capacitive coupling region and the capacitive coupler worn by the user. Coupling is conducted by capacitive conduction. It is noted herein that the same principles for the detector can also be applied to the actuators disposed on the medical delivery device. In one aspect, the housing defines an aperture for generating an acoustic wave when the user is inhaled through the device, and wherein the detector further includes a sound detector for detecting and inhaling the user via the device An associated sound wave travels through the body and air of the user, wherein the sound detector correlates sound waves passing through the user's body with sound waves passing through the air to confirm delivery of the dose to the user. In one aspect, a system is provided for delivering a pharmaceutical dose to a user and confirming delivery of the dose. The system includes a detector coupled to the user, wherein the detector collects physiological information related to the user for generating a profile related to the user, a device, wherein the device includes a The housing defines a chamber for storing the dose and an opening through which the user inhales to receive the dose and a sound unit for generating an acoustic signal. The sound unit is secured to the housing of the device. The sound unit comprises a floor which comprises a glue on a surface. 71 201208643 layer is used for fixing the sound unit to the device, and the vibration detecting unit is fixed to the support layer by means of the device and the The user inhales the generated sound information through the device and generates a signal, a controller fastens to the support layer and the vibration detecting unit rail, wherein the controller receives the vibration (four) unit The _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ And the __ top layer is destined to the branch of the branch to the sound unit, the control unit 5| and the sound generating unit in the (4). The sound signal represents the absorbing dose associated with loading into the cavity f and the user is associated with the inhalation via the device, and wherein the sound signal is detected by the detector to confirm the dose. Round. - In the second aspect, the system further includes at least two contact areas that are shouted out of the system. The contact regions are at least partially exposed to the outer casing and the at least two contact regions are electrically isolated from each other. This sound includes the power supply. The at least one contact region is coupled to one of the positive terminals of the power source, and the at least one other contact region is contacted by the user of the negative terminal terminal and the contact region. The messenger body completes the current path' and detects the current flow by the detector connected to the user. In one aspect, the controller is configured to control the information rotation from the sound early element. In the view, the controller is configured to change the current path

S 72 201208643 Conductivity 'Codes the poorness in the current flow. In one aspect, the sound unit further includes a memory unit electrically coupled to the controller for storage. In one aspect, the detector is configured to be implanted within the body of the user. The detector includes a sealed housing, a power source secured within the housing, and at least one sensing probe secured to the housing, wherein the probe is at least partially exposed for contacting the user tissue, wherein the detector is The probe is electrically coupled to the processor, such that the processor detects physiological parameters associated with the user and current flow through the user, a transceiver module electrically coupled to the processor and Fixed within the housing to receive information transmitted from the device and decoded, and a memory unit is electrically coupled to the processor and secured within the housing for storing data. In one aspect, the detector is configured to be secured to the skin of the user. The detector includes a housing, a power source secured to the housing, a processor electrically coupled to the power source and secured to the housing, and at least one sensing probe secured to the housing, wherein the probe system Electrically coupled to the processor for allowing the processor to detect physiological parameters associated with the user and current flow through the user, a transmitter module electrically coupled to the processor and secured to the processor The housing receives and decodes information transmitted from the device, and a memory unit is electrically coupled to the processor and secured within the housing for storing data. In one aspect, the system further includes a device that is secured to the housing of the device. The device provides a start signal to the detector and the detector includes an accelerometer electrically coupled to the processor and secured to the housing of the detector. The accelerometer is activated by the processor of the detector to detect an action when the 忒 detector receives the enable signal originating from the device. In the mirror point, the transceiver module provides wireless communication of the data from the detector to a data management center. In one aspect, a device is provided for detecting delivery of an inhalable medicament to a user. The device includes a vibration detecting unit for detecting sound information and generating a detecting signal, and a controller is in communication with the vibration detecting unit, wherein the controller receives the detecting signal originating from the vibration detecting unit and Generating a digital signal representative of the detection signal, a sound generating unit is fixed to the support layer and communicating with the controller, wherein the sound generating unit receives the digital signal and generates an acoustic signal indicating the inhalable dose delivery. In the opinion, the device further includes a transmission unit to communicate with the controller. The transmission unit receives the digital signal and is coupled to a wireless device to indicate that the inhalation event has occurred. In one aspect, the apparatus further includes a transconductance unit in communication with the controller. The transconductance unit includes at least two contact regions electrically isolated from each other and positioned to permit contact with each of the contact regions, and a power source. The at least one contact region is electrically coupled to one of the terminals of the power source and the at least one other contact region is electrically coupled to the other terminal of the power source. A current path is formed by the user's body 7L, allowing current to flow when the user is in contact with each of the two contact areas, and detecting current flow by the controller. In one aspect, the transconductance unit further includes a control module coupled to one of the power source and the at least two contact regions, the 201208643 gate is electrically connected to the 5H control module system. To compile the information in the current flow. In one aspect, 'providing a device for confirming delivery of a medical dose to a user. The device includes at least two contact regions electrically isolated from each other, and a power source includes a first terminal and a second terminal, wherein at least one of the contacts The area terminal electrical coupling and at least one other contact area are coupled to the second terminal book, and a control module is electrically connected between the first terminal of the power source and the wide-contact area thereof. The structure is configured to change the conductivity of the two users through contact with each of the two contact regions. When the user can contact each of the two contact regions via the use The body completes a current path. The change in conductivity encodes the information in the current flow. In the point of view, a method is provided for recording a day when a user takes a medical dose (4). When the user is in contact with the outside of the device, the mobile device-power module is completed in this manner, and the current flow between the two terminals of the "Hybrid" group and the user's body f' Using a material-like (four) module to form the current characteristics of the circuit through the user's limbs, the application-sound single = generate - sound signal causes the K detector to make the sound signal, wherein the sound The signal includes information associated with delivering the dose to the user: and a step of recording the delivery time of the inhalable dose. = Depending on the particulars, _ can be located for the organ of interest by a complex structure. For example, a letter (four) detector in which a single cell is used as a counter-measurement may be included, and the method may include initial positioning or implantation of the single-bit at the time of U 75 201208643, and the C-position of interest is closest to the organ of interest - Location. Located close to the lungs; the sputum is the lungs, and if required, the single-receiver can be ordered, 兮=where. The material method including two or more signal detectors can be used to package (4)-2. For example, the other locations i:: or more individual detectors are positioned in the vicinity of the lungs. The second detector is located at the front abdomen position and the second and second detectors are located at: Back position. The latter configuration represents the debt detectors: (10) 兮 - the instance + on the opposite side of the target organ, for example, to measure impedance, motion or sound through the organ. It should be understood that the present invention is not limited to the particular aspects described, but may be varied as such. It is also to be understood that the specific terminology used herein is for the purpose of illustration and description, and is not intended to be limiting, as the Ιε8# of the present invention will be limited only by the scope of the material to which the material is attached. In the range of values provided, 'should be understood to mean each of the median values, unless the context clearly indicates otherwise, the decile of the unit to the lower limit' is between the upper and lower limits of the range, and Any other statements or median values in this statement are included in the present invention. The above-mentioned upper and lower limits of such a small range may be independently included in the scope of the invention, and are included in the invention, and are subject to any specifically excluded team in the stated range. The scope of the statement includes one or both of the limitations, and the scope of the invention or the scope of the invention is also included in the invention. Unless otherwise defined, all technical and scientific uses used herein have the same general knowledge as commonly understood by those skilled in the art to which the invention pertains.

S 76 201208643 Any methods and materials similar or equivalent to those described herein can also be used in the examination of the present invention, but are now illustrative of the methods and materials. All the publications and patents cited in this specification are hereby incorporated by reference. (4) 'As per-tobacco disclosure == indication: as a reference material, and hereby incorporated as: Kaobeiwei (4) Reading Read the methods and/or materials of such public offices on a daily basis. The citation of any publication is hereby disclosed and is not to be construed as an admission that the invention is not Furthermore, the date of the public offering may be different from the actual publication date to be independently confirmed. > It should be noted that the terms "a", "an", and "the" are plural, unless the context clearly indicates otherwise. Indicator. It should be further = sound, that the scope of such patent applications can be written to remove any optional = parts. For its part, this statement is intended to be used in connection with the application of the details of the application, such as, for example, only (s〇lely) =, ,, only and similar, or The use of, negative, and the antecedent of the expression. The specific scope set forth herein is the term, approximately (ab〇ut), preceded by a numerical value. The term "about" used herein is about , providing literal support for the exact number before it, and a number that is close to or about the word of the aboriginal word before the term. In determining that a number is close to a certain number, which is approximately a detailed description, the proximity or approximation is not a word, and in the context of the proposal, a specific detail may be provided for a number of $77 201208643 Substantially equivalent. It will be apparent to those skilled in the art that upon reading this disclosure, it is obvious that each individual point of the description and illustration has individual constituents and characteristics that can be easily separated from those of any other plural. It may be combined with it without departing from the scope and spirit of the invention. Any of the detailed methods can be performed in the order in which they are described, or in any other order that is logically possible. Although the foregoing invention has been described in some detail and the embodiments of the embodiments of the present invention, the invention may be The spirit or scope of these additional patentable scopes. BRIEF DESCRIPTION OF THE DRAWINGS The novel features of the various aspects of the present invention are specifically set forth in the scope of the appended claims. However, the various points of view, in terms of the method of organization and operation, are illustrated by the following examples in conjunction with the accompanying drawings and the corresponding description. Figure 1A is an illustrative example of a user wearing a detector and in contact with a device, shown in the form of a block diagram in which an inhalation dose is delivered in accordance with the teachings of the present invention. Figure 1B shows a possible physical shape for the device of Figure 1A in accordance with the teachings of the present invention. Figure 1C shows the device of Figure 1A in accordance with the teachings of Figure 1A.

S 78 201208643 A viable solid shape. Figure 1D shows a possible physical shape for the device of Figure 1A in accordance with the teachings of the present invention. Figure 2A is an illustration of the block diagram shown in Figure 1A and the apparatus in accordance with the teachings of the present invention. Figure 2B is an illustration of the block diagram shown in Figure 1A and the apparatus in accordance with the teachings of the present invention. Figure 3A is an illustrative example of a user wearing a detector and in contact with a device, shown in block diagram form in which an inhalation dose is delivered in accordance with the teachings of the present invention. Figure 3B shows another possible physical shape for the device of Figure 3A containing a sound unit in accordance with the teachings of the present invention. Figure 3C shows another possible physical shape for the device of Figure 3A containing a sound unit in accordance with the teachings of the present invention. Figure 3D shows another possible physical shape for the device of Figure 3A containing a sound unit in accordance with the teachings of the present invention. Figure 3E is an illustrative example of a user wearing a detector and in contact with a device, shown in block diagram form, wherein an inhalation dose is delivered in accordance with another aspect of the present invention. Figure 3F is a side elevational view of a portion of the device of Figure 3E. Figure 4A is an alternative view of the apparatus of Figure 3A, shown in block diagram form and in accordance with the teachings of the present invention, including a sound unit. Figure 4B is an alternative view of the apparatus of Figure 3A, shown in block diagram form and in accordance with the teachings of the present invention, including a sound unit. 79 201208643 Figure 4C is a top plan view of a sound unit in accordance with one aspect of the present invention. Figure 4D is a diagram of a sound unit in accordance with one aspect of the present invention. Figure 4E is a diagram of a sound unit in accordance with one aspect of the present invention. Figure 5A is an illustrative example of a user wearing a detector and in contact with a device, shown in block diagram form in accordance with the teachings of the present invention. Figure 5B shows a possible physical shape of the device of Figure 5A having a device electrically coupled to the contact region in accordance with the teachings of the present invention. Figure 5C shows a possible physical shape of the device of Figure 5A having a device electrically coupled to the contact region in accordance with the teachings of the present invention. Figure 5D shows a possible physical shape for the device of Figure 5A in accordance with the teachings of the present invention having a device and a sound unit that are electrically coupled to the contact regions, respectively. Figure 5E shows a sound unit in accordance with one aspect and guidance of the present invention. Figure 5F shows a sound unit in accordance with another aspect and guidance of the present invention. Figure 6A is a view of the apparatus of Figures 5B, 5C and 5D, shown in block diagram form and in accordance with the teachings of the present invention. Figure 6B is the device of Figures 5B, 5C and 5D shown in block diagram form and in accordance with another aspect of the teachings of the present invention. Figure 7A is a view of the opening of the device of Figures 3, 3A and 5A in accordance with another aspect of the present invention, wherein a diaphragm is disposed adjacent the opening of the device through which the inhaled dose is delivered through the 201208643 . Figure 7B is a = (10) of the diaphragm of the device of Figure 7A divided into a few = when the user inhales the dose, the first beam is interrupted and the interruption is detected. The blade is a pattern of the diaphragm of the device of the diaphragm 7 A, wherein the film is divided into portions to cause the photograph. P-knife-chord movement and segmentation results in an interruption in a connection. The block ^ is one of the detectors of the picture recognition, the slave, and the eight-eighth. FIG. 9 is a block diagram of the processor of FIG. Figure (4) is an example of the invention of the invention of the county, the wearer and the case when the user inhales with a device. 4 contact for receiving-inhalation dose The device has the ability to record the timing of certain events associated with servicing the access device. Figure 12 is an illustrative example of a device in accordance with the teachings of the present invention, which is in the form of a device, which delivers a medical dose. The figure showing the guidance according to the invention is such that the medically delivered H is used for delivery by a pill reservoir - a separate pill. Figure 12C illustrates the view of Figure 12 of Figure 12 for the delivery of the Pill Storage H-individual (four) pill, which illustrates the use of Figure 28 in accordance with the teachings of the present invention. Delivery from a separate pill reservoir - a separate pill of the drug delivery skirt 201208643. Figure 13A is an illustrative example of a user wearing a detector and in contact with a device in accordance with the teachings of the present invention, shown in block diagram form, which delivers a medical dose. Figure 13B is a view of the medical delivery device of Figure 13A for delivering a separate pill from a tape containing a plurality of sealing pills therein in accordance with the teachings of the present invention. Figure 13C is a view of the tape in accordance with the teachings of the present invention, comprising a plurality of pills sealed in a package that can be coiled and inserted into a chamber of the device of Figure 13A. Figure 13D is a perspective view of the medical delivery device of Figure 13A for delivering a separate pill from a strip of a plurality of sealing pills therein, in accordance with the teachings of the present invention. Figure 13E is a top plan view of a tape delivery mechanism for liquid medical delivery from the perspective of one of the medical delivery devices of Figure 13A, in accordance with the teachings of the present invention. Figure 13F is a side elevational view of a tape delivery mechanism for liquid medical delivery from the perspective of one of the medical delivery devices of Figure 13A, in accordance with the teachings of the present invention. Figure 14A is an illustrative example of a user wearing a detector and in contact with a device in accordance with the teachings of the present invention, shown in block diagram form, which delivers a medical dose. Figure 14B is a view of the medical delivery device of Figure 13A for use in self-contained one of a plurality of sealed pills therein in accordance with the teachings of the present invention.

S 82 201208643 A separate pill is delivered in the tape while also delivering a dose of liquid. Figure 15A is an illustrative example of a user wearing a detector and in contact with a device in accordance with the teachings of the present invention, shown in block diagram form, which delivers a medical dose. Figure 15B illustrates an aspect of the medical delivery device of Figure 15A for delivering a single dose of liquid medication from a bladder in accordance with the teachings of the present invention. [Main component symbol description] AA contact area BB line 3 device 10 user 20, 20a detector 20b skin position 20c capacitive coupler 20d contact area 20e non-contact side 23 dose confirmation device 25 device 27 motorization unit 30, 30a device 30b power supply 30c capacitive coupler 30d contact area 31 sound unit 31a processing unit 31b sound generating unit 31c vibration detecting unit 83 201208643 31d microphone 31e amplifier 31f filter, waver 31g digital device 31h controller 31i power supply 31j power supply 31k amplifier 31m filter 31n sound generating unit 31p, 31q contact connecting portion 31r memory unit 32 housing 33 sound unit 33a, 33b connecting portion 34 power supply 35 magnet 36 control unit 37 coil 38, 40 contact area 41 fixed coil 41a, 41b connection Point 42 memory unit 43 movable coil 43a, 43b connection point 44 chamber 45 fixed plate 45a, 45b connection point 46 transceiver 47 movable plate s 84 201208643 47a, 47b connection point 50 opening 52 diaphragm 52a-52f portion 54a , 54b beam sensor 56 beam 58 Optical Clearances 58a, 58b Impedance Measurement Unit 60 Optical Sensor 62 Light Source 70 Processing Unit 72 Housing 74 Electrode 76 Coil 80 Amplifier 82 Conductor 84 Demodulator 85 Memory Unit 86 Clock 87 Power Supply 89 Transceiver Unit 90 Module 100 Access Device 102 needle portion 104 data collection module 106 access port 210 detector 310 hole π 320 port fitting 400 device s 85 201208643 402 housing 404 chamber 406 pill 406a single pill dose 408 delivery tube 410 actuator 412, 414 contact area 416 pill Valve 418 sealed package 420 electric pill valve 500 device 502 housing 504 tape 506 pill 508 pill delivery tube 510 chamber 512 knife 514 tape indicator 522 tape 524 pouch 526 liquid medical dose 600 device 602 housing 604 tape 606 second chamber 608 Duct 610 First Chamber 612 Wall 614 Liquid 700 Device s 86 201208643 702 Enclosure 704 Liquid Medicine 706 Pressurization Mechanism 708 Duct 710 Chamber 712 Flow Valve 714 Vent 716 Pouch 718 Movable Tablet 720 Removable Plug 87

Claims (1)

201208643 Seven patent application scope: 1. A system for delivering a dose to a user and for confirming the delivery of the dose, the system comprising: a detector configured to be coupled to the user; Wherein the device comprises: an external shouting defining a chamber for storing the dose; at least two contact regions disposed on the outer casing, wherein the contact regions are proximate or located in the outer casing Externally, and at least two contact regions are electrically isolated from each other; a mountain power source is fixed to the outer casing and includes a positive phase terminal and a negative phase terminal, wherein the at least the contact region is electrically connected to the positive a phase termination and at least another contact region are coupled to the negative phase termination; and wherein the user is in contact with each of the two contact regions: the current path is completed via the user's body, and the current The flow is detected by the detector connected to the user. 2. If you apply for a patent scope! The system of the item wherein the dose is an inhalable dose. The system of claim 1, wherein the dose is a single dose. The system of claim 1, further comprising a control module electrically coupled between the power source and one of the at least two contact regions, wherein the control module is configured Controls the information associated with the device. S 88 201208643 5. The system of claim 4, wherein the control module is electrically coupled to the at least two contact regions and the second terminal of the power source. 6. The system of claim 4, wherein the control module is configured to change the conductivity of the current path for encoding information in the current flow. 7. The system of claim 4, wherein the device further comprises a transceiver electrically coupled to the control module, wherein the information can be transmitted and/or received by the device in addition to the current flow. To the detector. 8. The system of claim 4, wherein the detector is configured to be implanted in the body of the user and the detector comprises: a sealed outer casing; a power source secured to the Inside the housing; the handle is electrically coupled to the power source and secured within the outer casing; Λ ^ at least one sensing probe secured to the housing, wherein the probe is exposed to the ground to the user Tissue contact, wherein the probe is electrically coupled to the processor such that the processor detects physiological parameters associated with the user and current flow when the user is in contact; and ▲ a memory unit Electrically coupled to the processor and fixed in the 5 liter housing for storing data; wherein the transceiver is electrically coupled to the processor and fixed in the housing to receive the semaphore transmitted from the device . 89 201208643 9. The system of claim 4, wherein the detector is configured to be secured to the user's skin and the detector comprises: a housing; a power source that is secured to the housing; a processor electrically coupled to the power source and secured to the housing; at least one sensing probe secured to the housing, wherein the probe is at least partially exposed to contact the skin of the user, wherein the probe The needle is electrically coupled to the processor for allowing the processor to detect physiological parameters associated with the user and current flow through the user; and a memory unit electrically coupled to the processor And secured to the housing for storing data; wherein the transceiver is electrically coupled to the processor and secured to the housing to receive information transmitted from the device and decoded. 10. The system of claim 9, wherein the transceiver is coupled to a data management center for communication to provide data for two-way wireless communication from the detector to the data management center. 11. If you apply. The system of claim 1 of the patent red square further comprises a sound unit fixed to the outer casing. 12. The system of claim n, wherein the sound unit comprises: a support layer comprising an adhesive layer on a surface for securing the sound unit to the device; ^ a vibration detecting unit Is fixed to the support layer to detect sound information 201208643 generated by the device and the user through the device and generate a detection signal; a controller fixed to the support layer and coupled with the vibration Detecting unit communication, wherein the controller receives a detection signal originating from the vibration detecting unit and generates a digital signal representing the detection signal; a sound generating unit fixed to the supporting layer and controlled Communication, wherein the sound generating unit receives the digital signal and generates the sound signal; and a top layer is secured to the support layer to define a chamber that contains and protects the vibration unit, the controller, and the chamber An indoor sound generating unit, wherein the sound signal represents the inhalable dose with the filling into the chamber and the user inhaling the phase via the device Associated information, and wherein the audio signal line to be detected by the detector to confirm delivery of the dose. 13. The system of claim 12, wherein the sound unit is coupled to a control module. 14. The system of claim 13, wherein the sound unit provides a start signal to the control module when detecting a vibration representative of loading a medical dose into the chamber. 15. The system of claim 13, wherein the sound that is loaded into the chamber activates the control module, and wherein when the user is about to receive a dose of a medicine - the user and Each of the contact areas is in contact with a current path through the user's body. The system of claim 13 wherein the sound unit provides a start # to the control module and the control module records sound information associated with the user's inhalation, wherein the information is via The sound detector is provided to the control module. 17. The system of claim 4, wherein the control module provides a unique time stamp associated with the delivery of the dose, and wherein the control module receives a recognizer signal associated with the user And wherein the combination of the time stamp and the identifier signal confirms delivery of the dose to the user. 18. Apparatus for delivering a dose to a user and tracking the timing of delivery of the dose, the apparatus comprising: a housing defining a chamber to store the dose; at least two contact regions, the configuration On the exterior of the housing, wherein the contact regions are configured to be in contact with the user and wherein the 5H contact regions are electrically isolated from each other; and a power source is secured to the housing to provide power To generate a current flow through the body of the user, wherein the power source includes a positive terminal and a negative terminal, wherein the at least one contact region is electrically coupled to the positive terminal and the at least another contact region is electrically coupled to The negative terminal terminates in the circuit when the user contacts each of the at least two contact regions to generate a circuit that causes a current to flow through the user's body. For example, in the scope of the patent application 帛18, the worker further includes a control S 92 201208643 eight-line solid to the outer casing and each of the two contact regions, wherein the 5 hai control module changes the current flow One of the conductivity codes in the current flow. The device of claim 19, wherein the control module provides an associated-only time stamp for the delivery in the back, and wherein the = module receives - identifies the listener, which is associated with the user: The combination of the signal and the Lai (4) signal confirms that the dose is 21. 21. Please specify the scope of the 19th segmentation. The step-by-step contains a memory that is integrated into the control group and fixed to the outer casing. The group stores information associated with the dose. The apparatus of claim 19, wherein the step-by-step includes-transceiving = is coupled to the control module and fixed to the housing, wherein the device transmits and/or receives and transmits the dose to the use Information associated with the person. The device of claim 22, wherein the transceiver comprises at least one of a wireless transmission $module and a wireless converter for wireless communication. " H monthly patents for the device of Section 22, wherein the transceiver encodes information from the =memory unit and a system that transmits the information externally. 25. The device of claim 24, wherein the transceiver passes the use of the body completion circuit, the transceiver sends a start signal to the external system, wherein the activation signal is prepared for the user to start delivering the 93 201208643 An indicator of the dose. 26. The device of claim 18, further comprising a sound unit that is secured to the outer casing.曰27. The device of claim 26, wherein, once the sound unit receives the activation signal originating from the device, the sound unit 2 - the processor is activated to detect originating from the user's lung Sound information. 28. The device of claim 26, wherein the sound unit comprises: a support layer comprising an adhesive layer on a surface for securing the sound unit to the device; ▲ - vibration_unit, The control layer is configured to detect the sound information generated by the device and the user through the device and generate a detection signal; the control benefit is fixed to the support layer and the vibration detection a test 'in which the control|| receives a beta signal originating from the oscillating detection unit and generates a digital signal representative of the detection signal; and a sound generating unit fixed to the support layer and Controlling, wherein the sound generation unit receives the digital signal and generates the sound signal; and a top layer secured to the support layer to define a chamber that contains and protects the hard unit, the control H And a sound generating unit within the chamber, wherein the 5 Hz sound signal represents the inhalable dose loaded into the chamber, the user inhaling the associated information via the device, and The sound signal is detected by the sound unit to confirm the delivery of the dose of S 94 201208643. 29. A system for delivering a dose to a user for confirming delivery of the dose, the system comprising: a detector comprising a capacitive coupler, wherein the detector is in communication with The user is connected; and a device comprising: a housing defining a chamber for storing the dose; a power source secured to the housing and including a positive terminal and a negative terminal, wherein the power source comprises Generating an isolation source of one carrier; a control module electrically coupled to the power source, wherein the control module changes characteristics of the isolation source to encode information in the carrier; and at least two regions are configured In the housing, one of the regions is a partially exposed contact region and a region is a capacitive coupling region, wherein the two regions are electrically isolated from each other, wherein one of the isolation sources is coupled to the contact region And the other output of the isolation source is coupled to the capacitive coupling region, wherein the contact region is touched by the user and the capacitive coupling region is capacitively coupled And the capacitive coupler worn by the user, and wherein a portion of the carrier path passes through the user body using the contact area, and a portion of the carrier path is used between the capacitive coupling region and The capacitive coupling between the capacitive couplers worn by the user is capacitively conducted. The system of claim 29, wherein the housing defines an aperture for generating an acoustic wave when the user inhales through the device, and wherein the housing is 5 Further comprising a sound unit for detecting sound waves associated with the user inhaling through the device, the sound waves passing through the use, body and air 'where the sound unit causes sound waves passing through the user's body to pass through the air Sound waves are associated to confirm delivery of the dose to the user. The device for detecting a dose to a user, the device comprising: a vibration detecting unit for detecting sound information and generating a detecting signal; a controller communicating with the vibration detecting unit The controller receives a detection signal originating from the vibration detecting unit and generates a digital signal representing the debt measurement signal; a sound generating unit is fixed to the branch floor and communicates with the controller, wherein the controller The sound generating unit receives the digital signal and generates a sound signal indicative of the delivery of the dose. The device of claim 31, further comprising a transceiver in communication with the controller, wherein the transceiver receives the digital signal and communicates with a wireless device to indicate that the inhalation event has occurred. The device of claim 32, further comprising a transconductance unit in communication with the controller, the transconductance unit comprising: at least two contact regions electrically isolated from each other and positioned to allow each connection Point area contact; S 96 201208643 a power source, wherein the at least one contact area is electrically coupled to one of the terminals of the power source and the at least one other contact area is electrically coupled to another terminal of the power source, wherein the user When each of the two contact regions is in contact, a current path is completed through the user's body to allow current to flow, and current flow is detected by the controller. 34. The device of claim 33, wherein the transconductance unit further comprises a control module electrically connected to the power source and one of the at least two contact regions, wherein the control module The structure is configured to encode the poorness in the current flow. 35. A method for recording a time when a user takes a dose, the method comprising the steps of: initiating a power module of a device to complete a circuit when the user is in contact with an exterior of the device Flowing between the terminals of the power module and through the body of the user; changing the current characteristics by changing the conductivity of the circuit, which is formed by the user's body using a conductive control module; The detector detects a current characteristic through the body of the user, wherein the current characteristic includes a tribute associated with at least one of the device and the dose, and a timing at which the delivery of the inhalable dose is recorded. 36. The method of claim 35, further comprising: generating a sound signal using a sound unit; and detecting the sound signal using a sound unit, wherein the sound signal 97 201208643 includes relating to delivering the dose to the user Linked information. S 98