201204743 六 發明說明： 【發明所屬之技術領域】 胺飲種葡萄糖胺飲粉末，該葡萄糖 造多種不同劑型之產品及增加攜帶方便性。 表 【先前技術】 目剛市售多種固骨營養品，葡萄糖胺飲 =百要的選擇’能針對各年齡層不同之骨 需求做保養，但飲品之容器規格都500毫升以上： =出旅仃之方便性大打折扣，不僅增加攜帶負擔，、 對於萬搭乘飛機之使用者更是大大的不便。 ° 由於里灣天氣屬悶熱型態，葡萄糖胺飲開罐後 需冷藏以避免微生物之滋長，葡萄糖胺飲内所含之 萄糖胺鹽酸鹽一曰限制量為15〇〇亳克以下，一瓶】 :胺飲勢必能喝上一段時間，於瓶蓋開開關關的同 時，被汙染的機會相對增加，為避免微生物之汙染， 配方中添加防腐劑就是保障飲品安全所必需的。 考篁到先前技術中的缺陷，本案發明人基於多 經驗從事研究並多次修改，遂於本發明提出一種葡萄 糖胺飲粉末，利用喷霧乾燥技術將葡萄糖胺飲之液熊 形式轉變為固態粉末，以增加攜帶之方便性，且小^ 位分裝可避免重複污染，避免開瓶後須冷藏等困擾， 更重要的f能降低甚至不需要添加防腐劑。本發明不 僅可用於藥品、健康食品的生產領域，更可以應用於 醫藥產業做改善劑型生產之新型技術。 201204743 【發明内容】 有鑑於此’本發明之目的就是在提供一種葡萄糖胺 飲粉末，葡萄糖胺飲藉由喷霧乾燥技術，將原先之液 態形式轉變為固態粉末形式，藉以增加製造多種劑型 及增加攜帶之方便性。 該葡萄糖胺飲係由膠原蛋白、軟骨素、葡萄糖胺、 香料、甜味劑及水份所組成，而該配方成份之軟骨素 係由豬骨骼、雞骨骼或鯊魚骨骼所提煉出之軟骨素201204743 6 Description of the invention: [Technical field to which the invention pertains] Amine drinking glucosamine powder, which produces a variety of products in different dosage forms and increases portability. Table [Prior Art] Mugang just sells a variety of solid bone nutrition products, glucosamine drink = a hundred choices 'can be maintained for different bone needs of all ages, but the container size of the drinks are more than 500 ml: = out of the hotel The convenience is greatly reduced, which not only increases the carrying burden, but also greatly inconveniences for users who fly on the plane. ° Because the weather in Liwan is sultry, glucosamine drink should be refrigerated after opening the can to avoid the growth of microorganisms. The limit of glucosamine hydrochloride contained in glucosamine drink is less than 15 gram. Bottle]: The amine drink will be able to drink for a while. When the bottle cap is opened and closed, the chance of being contaminated is relatively increased. To avoid microbial contamination, adding preservatives to the formula is necessary to ensure the safety of the beverage. Considering the defects in the prior art, the inventor of the present invention conducted research based on multiple experiences and modified many times. In view of the present invention, a glucosamine powder was proposed, and the liquid bear form of glucosamine was converted into a solid powder by a spray drying technique. In order to increase the convenience of carrying, and small-sized dispensing can avoid repeated pollution, avoid the need to refrigerate after opening the bottle, etc., more importantly, can reduce or even eliminate the need to add preservatives. The invention can be applied not only to the production of medicines and health foods, but also to the pharmaceutical industry as a new technology for improving the production of dosage forms. 201204743 [Description of the Invention] In view of the above, the object of the present invention is to provide a glucosamine powder, which is converted into a solid powder form by a spray drying technique, thereby increasing the manufacture of various dosage forms and increasing The convenience of carrying. The glucosamine drink is composed of collagen, chondroitin, glucosamine, flavor, sweetener and water, and the chondroitin of the formula is chondroitin extracted from pig bone, chicken bone or shark bone.
此發明之葡萄糖胺飲粉末亦可添加如鈣、玻尿酸及 銀杏等補骨抗老成份，用以增加其產品之功效訴求及 強化其效性成份，而此葡萄糖胺飲粉末經噴霧乾燥 後，泫粉末為即溶形式，對水之溶解力更優於配方原 料粉末對水之溶解力。 ' ” 此外，此葡萄糖胺飲粉末亦可以下列步驟製成腸溶 緩釋微粒： 步驟1 :葡萄糖胺飲粉末與溶劑混合後經擠壓搓 圓’造粒並烘乾後即為效性核心部份； 步驟2 :於效性核心外部噴上腸溶膜衣以做為效性 核心之保護層，可有效降低葡萄糖胺飲粉末之效性成 份遭受胃酸之破壞；及 '步驟3:於腸溶膜衣外層包覆一層葡萄糖胺飲粉末 以做為釋放層’方便葡萄糖胺飲粉末之效性成份於短 時間内之釋放。 此葡萄糖胺飲粉末亦可經製錠技術製成雙層錠、發 泡錠、緩釋錠等相關錠劑劑型。 承上所述’因依本發明之葡萄糖胺飲粉末，具有 201204743 以下優點： (1) 此葡萄糖胺飲粉末可有效除去葡萄糖胺飲攜帶 不便及體積過大之問題。 (2) 此葡萄糖胺飲粉末可以經微粒及製錠技術創造 出更多不同劑型。 (3) 此葡萄糖胺飲粉末可廣泛運用於保健食品及醫 藥品等領域。 【實施方式】 本巧明人經過廣泛而深入的研究和實驗，最終找 到一種葡萄糖胺飲粉末，多種試驗表明，所述的葡萄 糖胺飲粉末除可增加使用者攜帶之便利性，更可因粉 末型式創造出多種不同劑型。基於此本發明得以完成。 依本發明之葡萄糖胺飲粉末，其葡萄糖胺飲係以 固定重1百分比之膠原蛋白3〜7%、軟骨素3〜7%、葡 萄糖胺3〜7%、香料6〜1〇%、甜味劑卜3%及水份 70〜80 /〇所組成’此配方成份中之軟骨素係由豬骨骼、 雞骨骼或鯊魚骨骼所提煉出，而配方中亦可添加如 鈣、玻尿酸、、軟骨素等補骨抗老成份，用以增加其產 品之功效訴求及強化其效性成份。 此lx明之葡萄糖胺飲粉末係藉由噴霧乾燥技術將 液態形式之葡萄糖胺飲轉變為固態形式之葡萄糖胺飲 =末二將葡萄糖胺飲在熱風中喷霧成細小的液滴，在 它下落過程中，水分被蒸發成為粉末或顆粒狀的產 品，稱為噴霧乾燥。經喷霧器霧化的液滴，表面積报 大’與高溫熱風接觸後水分迅速蒸發，在極短的時間 201204743 内便成為乾燥產品。 5〜公升液體在高溫氣流中 不高，產品、:質;：彻。乾燥叫 過程的分散性、流動性和溶解性，乾燥 球狀，：產二Ϊ ’產品基本上能保持與液滴相同的 操作控制方便’大部分產品不The glucosamine powder of the invention may also add bone and anti-aging ingredients such as calcium, hyaluronic acid and ginkgo to increase the efficacy of the product and enhance its effective ingredients, and the glucosamine powder is spray-dried, The powder is in an instant form, and the solubility in water is better than the solubility of the raw material powder in water. In addition, the glucosamine powder can also be made into enteric sustained-release microparticles by the following steps: Step 1: The glucosamine powder is mixed with the solvent and then squeezed and granulated to be granulated and dried. Step 2: Spraying the enteric film on the outer core of the effective core to serve as the protective core of the active core, which can effectively reduce the damage of the acid-soluble component of the glucosamine powder; and [Step 3: Intestine dissolution] The outer layer of the film coat is coated with a layer of glucosamine powder as a release layer to facilitate the release of the glucosamine powder powder in a short period of time. The glucosamine powder can also be made into a double-layer ingot by the ingot technology. Infusion tablets, sustained-release ingots and other related lozenge dosage forms. According to the above-mentioned glucosamine powder according to the invention, it has the following advantages: 201204743: (1) The glucosamine powder can effectively remove the inconvenience and volume of the glucosamine drink. The problem is too large. (2) This glucosamine powder can create more different dosage forms through microparticle and ingot technology. (3) This glucosamine powder can be widely used in health foods and pharmaceuticals. The method of application: After a thorough and in-depth study and experiment, Ben Qiaoming finally found a glucosamine powder, and various tests showed that the glucosamine powder can increase the convenience of the user, but also because of the powder type. A variety of different dosage forms are created. Based on the present invention, the glucosamine powder according to the present invention has a glucosamine drink with a fixed weight of 1% collagen 3 to 7%, chondroitin 3 to 7%, and glucosamine 3 ~7%, 6~1% of spices, 3% of sweeteners and 70~80% of water. 'The chondroitin in this formula is extracted from pig bones, chicken bones or shark bones. Formulations such as calcium, hyaluronic acid, and chondroitin may also be added to supplement the anti-aging ingredients of the product to increase the efficacy of the product and enhance its effectiveness. The lxamine glucosamine powder is liquid by spray drying technology. The form of glucosamine drink is converted into a solid form of glucosamine drink = the last two glucosamine drink is sprayed into fine droplets in hot air, and during its falling, the water is evaporated into powder or granules. The product is called spray drying. The droplets atomized by the sprayer have a large surface area. After contact with high temperature hot air, the water evaporates quickly and becomes a dry product within a very short time of 201204743. 5~liter liquid in high temperature airflow Medium is not high, product, quality:: thorough. Drying is called process dispersion, fluidity and solubility, dry spherical,: production of two Ϊ 'products can basically keep the same operation control with droplets. Product not
喷霧乾燥主要分四階段，喷霧化、喷霧；與 接觸、水分㈣霧液滴蒸發及葡萄糖胺飲S末回收。、 該葡萄糖胺飲粉末因粉末表面多孔洞，對水之溶 力更優於原料粉末對水之溶解力，為所謂之即溶形 而此葡萄糖胺飲粉末亦可利用微粒製造技術製造 出腸溶緩釋微粒及微粒劑型飲品，葡萄糖胺飲粉末與 2混σ後呈麵糰狀，經擠壓成長條狀後等距切割成小 奴’再經離心機搓圓，搓圓後烘乾即為效性核心，為 此微粒之緩釋層。 t效性核心區域外部噴上一層腸溶膜衣，此腸溶 膜衣需至腸道之環境中才會溶解，並將其效性成份釋 放出’可有效保護核心區域之效性成份通過胃酸之分 解破壞，即為所謂之保護層。 最後於腸溶膜衣之外層噴上一層葡萄糖胺飲粉 末’可方便葡萄糖胺飲在短時間内在人體之釋放吸 收，為此微粒之快速釋放層。 201204743 此葡萄糖胺微粒包含之快速釋放層、保護層及緩 釋層可有效拉長效性成份之釋放時間，一次提供短時 間及長時間之效性成份釋放。 本發明之葡萄糖胺飲粉末亦可利用海藻酸鈉及氯 化約之金屬螯合作用產生膠體微粒以作為微粒劑型之 飲品，而葡萄糖胺飲粉末可用製錠技術製成雙層錠、 發泡錠、緩釋錠等錠劑劑型，而直接充填入膠囊殼中 製成膠囊劑型亦是可行之製程之一。 Φ 上述之多種劑型及基礎葡萄糖胺飲粉末可廣泛運 用於保健食品及醫藥品等領域’經噴霧乾燥後葡萄糖 胺飲粉末用途之多源性比原先之液態形式多得多，縮 小體積增加便利性更是提升相關產品之附加價值。 本發明僅對上述實施例加以詳細說明，但熟悉該 項技術者應可明白，在本發明的技術思想範圍内可作 多樣的變形及修飾，該變形及修飾當然包含申請專利 範圍内。 ® 【圖式簡單說明】 益 【主要元件符號說明】 益Spray drying is mainly divided into four stages, sprayed and sprayed; contact with, moisture (iv) mist droplet evaporation and glucosamine drink S end recovery. The glucosamine powder has a porous surface on the surface of the powder, and the solubility to water is better than the solubility of the raw material powder to water, which is so-called instant dissolution. The glucosamine powder can also be made into an enteric solution by using microparticle manufacturing technology. Sustained-release microparticles and microgranular beverages, glucosamine powder and 2 mixed sigma are dough-like, and after being extruded into strips, they are equally cut into small slaves, and then centrifuged to round the circle. Sex core, for this release layer of microparticles. The t-effect core area is sprayed with an enteric film coat. The enteric film coat will dissolve in the environment of the intestines, and the effective ingredients will be released to remove the effective ingredients in the core area. The decomposition and destruction is the so-called protective layer. Finally, a layer of glucosamine powder is sprayed on the outer layer of the enteric film coat to facilitate the release of the glucosamine drink in the human body in a short time, and the rapid release layer of the particles. 201204743 This glucosamine microparticle contains a quick release layer, a protective layer and a release layer which can effectively extend the release time of the effective ingredient, and provide a short-term and long-term release of the active ingredient at one time. The glucosamine powder of the present invention can also be used as a microparticle dosage form by using sodium alginate and chlorinated metal chelate to produce colloidal particles, and the glucosamine powder can be made into a double-layer ingot and a foamed ingot by using an ingot technique. A dosage form such as a sustained-release tablet, which is directly filled into a capsule shell to form a capsule dosage form, is also one of the feasible processes. Φ The above various dosage forms and basic glucosamine powder can be widely used in health foods and pharmaceuticals. 'The multi-source of glucosamine powder after spray drying is much more than the original liquid form, and the volume is increased and the convenience is reduced. It is to increase the added value of related products. The present invention has been described in detail with reference to the preferred embodiments of the present invention, and it is understood that various modifications and changes may be made without departing from the scope of the invention. ® [Simple description of the schema] Benefits [Main component symbol description]