TW201111501A - High throughput cell culture system capable of providing mechanical force pressing stimulation - Google Patents

High throughput cell culture system capable of providing mechanical force pressing stimulation Download PDF

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Publication number
TW201111501A
TW201111501A TW98132918A TW98132918A TW201111501A TW 201111501 A TW201111501 A TW 201111501A TW 98132918 A TW98132918 A TW 98132918A TW 98132918 A TW98132918 A TW 98132918A TW 201111501 A TW201111501 A TW 201111501A
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TW
Taiwan
Prior art keywords
culture
pressure
mechanical force
chamber
cell culture
Prior art date
Application number
TW98132918A
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English (en)
Chinese (zh)
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TWI379000B (https=
Inventor
min-xian Wu
Jun-Li Lin
Xiao-Wen Cai
Heng-Liang Liu
yan-ting Liu
Original Assignee
Univ Chang Gung
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Application filed by Univ Chang Gung filed Critical Univ Chang Gung
Priority to TW98132918A priority Critical patent/TW201111501A/zh
Priority to US12/651,905 priority patent/US8980624B2/en
Publication of TW201111501A publication Critical patent/TW201111501A/zh
Application granted granted Critical
Publication of TWI379000B publication Critical patent/TWI379000B/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/14—Pressurized fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
TW98132918A 2009-09-29 2009-09-29 High throughput cell culture system capable of providing mechanical force pressing stimulation TW201111501A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
TW98132918A TW201111501A (en) 2009-09-29 2009-09-29 High throughput cell culture system capable of providing mechanical force pressing stimulation
US12/651,905 US8980624B2 (en) 2009-09-29 2010-01-04 Apparatus for high-throughput cell culture with mechanical compression stimulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW98132918A TW201111501A (en) 2009-09-29 2009-09-29 High throughput cell culture system capable of providing mechanical force pressing stimulation

Publications (2)

Publication Number Publication Date
TW201111501A true TW201111501A (en) 2011-04-01
TWI379000B TWI379000B (https=) 2012-12-11

Family

ID=43780825

Family Applications (1)

Application Number Title Priority Date Filing Date
TW98132918A TW201111501A (en) 2009-09-29 2009-09-29 High throughput cell culture system capable of providing mechanical force pressing stimulation

Country Status (2)

Country Link
US (1) US8980624B2 (https=)
TW (1) TW201111501A (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107603878A (zh) * 2017-09-05 2018-01-19 广东省第二人民医院 一种体外模拟按压环境下的细胞培养装置及其方法
CN114134042A (zh) * 2013-09-05 2022-03-04 伯尔尼大学 用于体内器官组织的体外模型化的装置

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016196233A1 (en) 2015-05-30 2016-12-08 Genomatica, Inc. Vinylisomerase-dehydratases, alkenol dehydratases, linalool dehydratases and/ crotyl alcohol dehydratases and methods for making and using them
WO2019086702A1 (en) 2017-11-06 2019-05-09 Fondazione Istituto Firc Di Oncologia Molecolare (Ifom) Cell compression device
CN108728360B (zh) * 2018-06-09 2024-04-09 上海天引生物科技有限公司 一种细胞共培养的装置及其方法
TWI732357B (zh) 2018-12-27 2021-07-01 財團法人工業技術研究院 細胞培養裝置及方法
JP2020110117A (ja) * 2019-01-15 2020-07-27 株式会社島津製作所 細胞処理容器及び細胞処理装置
CN112877212A (zh) * 2021-03-08 2021-06-01 大连医科大学附属第一医院 一种基于微流控芯片的仿生体内关节软骨微环境的结构
CN120173741B (zh) * 2025-05-21 2025-08-12 江苏艾玮得生物科技有限公司 体外模型培养芯片、装置及动态培养系统

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153136A (en) * 1988-07-22 1992-10-06 Vandenburgh Herman H Apparatus for growing tissue specimens in vitro
US6048723A (en) * 1997-12-02 2000-04-11 Flexcell International Corporation Flexible bottom culture plate for applying mechanical load to cell cultures
FR2803852B1 (fr) * 2000-01-17 2004-11-05 Farzin Sarem Dispositif de culture cellulaire et tissulaire a circulation de fluide de culture controlee
US6653124B1 (en) * 2000-11-10 2003-11-25 Cytoplex Biosciences Inc. Array-based microenvironment for cell culturing, cell monitoring and drug-target validation
WO2004094586A2 (en) * 2003-04-18 2004-11-04 Carnegie Mellon University Three-dimentional, flexible cell growth substrate and related methods
US8557582B2 (en) * 2007-09-28 2013-10-15 Christopher MORAES System, apparatus and method for applying mechanical force to a material

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114134042A (zh) * 2013-09-05 2022-03-04 伯尔尼大学 用于体内器官组织的体外模型化的装置
CN107603878A (zh) * 2017-09-05 2018-01-19 广东省第二人民医院 一种体外模拟按压环境下的细胞培养装置及其方法
CN107603878B (zh) * 2017-09-05 2025-08-08 广东省第二人民医院 一种体外模拟按压环境下的细胞培养装置

Also Published As

Publication number Publication date
US8980624B2 (en) 2015-03-17
US20110076758A1 (en) 2011-03-31
TWI379000B (https=) 2012-12-11

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