201109025 六、發明說明： 【發明所屬之技術領域】 法 與應用產品 【先前技術】 本發明是有關於-種植物萃取液及其製法，特別是指 -種可用於改善皮膚之不適症狀的諾麗果萃取液及其製 諾麗―…其學名為Morindacitrif〇lia，屬於巴戟屬 (M〇rinda)茜草科（Rubiaceae)植物，主要分布於熱帶亞洲、 澳洲、夏威夷及玻里尼西亞等太平洋諸島。諾麗植物從果 貫、種子、花朵、樹皮 '樹莖及樹根本身都有藥用成份，大 溪地當地的居民身體不舒服時，往往直接將諾麗果實榨成汁 液，或將諾麗葉子、種子、樹根等晒乾磨成粉，或加水熬煮 服用。 一直以來，諾麗被人們認為具有神奇的醫療功效，當 熟果採收後，洗淨風乾，置放於密閉容器中，經自然發酵二 17 U液服用。另外’亦可將其乾燥後研磨成粉末服用， 據说具有強化内分泌系統、排毒、抗癌及治療皮膚病等效 果。針對諾麗果在食用上的特殊效果，目前國内、外已有多 項學術論文發表。雖'然諾麗植物含有豐富的營養成分而為極 2 α濟彳貝值的植物，但目前在使用上仍是以食用或口服為 此外，對諾麗果的生理功能及其對人體的作用機制與生 化過知還有許乡待研究發展的㈣，·，目前仍有持.續財 發諾麗果新用途的需求。 【發明内容】 201109025 因此，本發明的目的，是在提供一種能夠 的 果實中萃取有效成分以廡士金 — 於改q皮膚之不適症狀的諾麗 果萃取液的製法。 於是本發明祐麗果萃取液的製法包含下列步驟： 以獲 ⑴將預定量的成熟諾麗果實洗淨後，再進行乾燥 得一諾麗乾果原料； ⑼以-溶劑浸泡該乾果原料，使溶劑淹沒該乾果原料 並靜置7天以上以獲得—諾麗果浸潰組成物； (出）以-具有預定孔徑的㈣元件過遽該諾麗杲浸潰組 成物以獲得一粗萃取液；及 …㈣在該粗萃取液中添加—預定4的驗性溶液並調整該 粗萃取液的pH值為弱酸性至中性，以製得最終的諾麗果萃 、本發明諾麗果萃取液的製法的有益效果在於：能以溶 a /包的方式取得諾麗果粗萃取液，再將該粗萃取液的酸 驗值調整為與人體肌膚相接近，就能製得適用於皮膚 終諾麗果萃取液’而具有容易製造且實用價值高的特性。 進一步地，本發明還提供以线製法所製得而適用於 改善皮膚不適狀況的諾麗果萃取液。 本發明諾麗果萃取液的有益效果在於..：能利用萃取液 已接近人體皮膚酸驗值的特性，及其中所含的諾麗果溶出 ，分’有效減輕皮膚的不適症狀，並能使皮膚快速恢復正 韦外觀，此外，由於該萃取液來源為天然物質，不易產生 不良副作用’而具有可發展為皮膚外用產品的應用價值。 201109025 較佳地’本發明還進一步提供以該諾麗果萃取液為主 成分而製出並能方便使用的諾麗果萃取液的應用產品。 该諾麗果萃取液的應用產品包含依預定比例相混合的 一主要組份及一基底組份。 該主要組份是取自前述製法所製得的諾麗果萃取液。 該基底組份為一選自下列群組中的物質：水、甜杏仁 油（sweet almond oil)、荷荷芭油（j〇j〇ba 〇il)、葡萄子油 (grape seed oil) ' 月見草油（evening primr〇se 〇ii)、玫瑰籽油 (rosehip oil)、小麥胚芽油（wheat germ 〇π)、鱷梨油 oil)思仁’由（j〇b s tears)、茶子油（tea seed oil)，及此等的 一組合。 本發明諾麗果萃取液的應用產品的有益效果在於：以 該諾麗果萃取液為主要組份搭配該基底組份就能製成水 劑、油劑 '乳液及膏體等不同型式的應用產品，並能將該 萃取液稀釋為適當濃度以方便使用者直接噴塗或塗抹使 用，由於該應用產品是由天然物質製成，相對於其他化學 合成乳液或貧體，較不易對皮膚造成不良反應，使本發明 具有使用效果佳且不易產生不良副作用的特性與優點。 【實施方式】 有關本發明之前述及其他技術内容、特點與功效，在 以下配a參考圖式之數個較佳實施例的詳細說 清楚的呈現。 將 .參閱圖1，本發明諾麗果萃取液的製法的一第一較佳實 施例’包含下列步驟： 201109025 步驟101 S採收成熟的諾麗果f，並將預定量的諾麗 果實以水洗淨風乾後，靜置發酵再進行乾燥以獲得一諾麗 乾果原料。由於諾麗果含有高量哮素’因此不需添加其他 物質促進發酵，靜置即可自行發酵。其中，也可以不進行 靜置發酵，而於洗淨後直接乾燥製得該諾麗乾果原料，但 错由靜置發酵可在後續的萃取過程中增加有效成分的溶出 量。 步驟102是添加醋液至該乾果原料’最好能使錯液淹 沒該乾果原料，若醋液未能淹沒該乾果原料，則需授掉使 該乾果原料表面均佈滿醋液為宜。在本實施例中，該乾果 原料與醋液的重量比例為1:2，且以醋液浸沒該乾果原料 的時間較佳為1天。因醋液職驗值約為pH3〜4，與諾麗之 酸驗值相近’藉此，可進一步增加該諾麗果中有效成分的 溶出量’還能利用醋液維持話麗之酸驗值及抑制微生物滋 生。 步驟103是以一溶劑浸泡經步驟1〇2處理過的乾果原 料’使溶劑淹沒該乾果原料並靜置7天以上以獲得一諾麗· 果浸潰組成物，並使諾麗果中的有效成分釋出至該溶劑 中。其中，該乾果原料與該溶劑的重量比例較佳為丄： 1 3。此外’ &泡該乾果原料所用的溶劑種類不應受限，只 要能提取出該諾麗果中有效成分的溶劑皆可使用，在本實 知例中’為了減少化學物質殘留及避免使用化學物質導致 不良副作用’而選用水作為該溶劑，且該乾果原料與水的 重量比例實質上為1 : i。進行此步驟時，由於步驟1〇2所 201109025 添加的醋液中已溶有高濃度的諾麗果成分，因此’在此步 驟中醋液不需倒出而是直接加水。 步驟104是以一具有預定孔徑的過濾元件過濾該諾麗 果浸潰組成物以獲得一粗萃取液，在此是以棉花或紗布過 遽s亥 >文 >貝组成物以濾除其固體物質部分，並獲得該粗萃取 液0 步驟105是在該粗萃取液中添加一預定量的鹼性溶液 並调整该粗萃取液的pH值為弱酸性至中性，以製得最終的 ,结麗果萃取液。纟此，所用的鹼性溶液為三乙醇胺 (triethanolamine)，且為了使該萃取液更適用於身體各部位 皮膚’是將該粗萃取液的pH值調整為接近一般肌膚酸驗值 的pH5.5〜7。藉此’使所製得的該諾麗果萃取液極適合供皮 膚外用其中，二乙醇胺是廣泛用於各類洗蘇劑和美容護 膚品，例如，皮膚洗務、眼膠、保濕、洗髮劑等用品中的 P平衡d因此’在此也使用三乙醇胺調整該粗萃取液 pH值。 參_ 2’為本發明諾麗果萃取液的製法的—第二較佳 實施例’該第二較佳實施例的步驟.2〇1、2()4及2〇5分別盘 該第一較佳實施例的步驟⑻、1G4&⑽相同，不再警 述。主要差別為步驟202及步驟203的處理方式。 步驟202是以道声的& ^co/ a 料，以去崎㈣跑醇嶋洗該乾果原 乾果Π 2:二以水作為溶劑浸泡經步驟202處理過的 乾果原枓，在本貫施例t，該乾果原料與水的重量比例^ 201109025 1 : 3，也就是丨重量份的乾果原料中共加入3重量份的 ^八中這3重夏份的水將分2次加入，且2次之間間 隔1天帛後’同樣是靜置7天以上，以使諾麗果中的有 效成分釋出至水中。 A透過該第二較佳實施例，同樣能製得具有適當pH值及 含有諾麗果中有效成分而適於皮膚外用的諾麗果萃取液。 以D玄第一、第二較佳實施例的方法製得該諾麗果萃取 液，除了可以直接用水稀釋後用於浸泡皮膚外，還能進一 步搭配特定的基底組份製成方便一般使用者塗用的應用產 品。 。亥諾麗果萃取液的應用產品的較佳實施例包含依預定 比例相混合的一主要組份及一基底組份。 。玄主要組伤疋取自以該第一較佳實施例或該第二較佳 實施例的製法所製得的諾麗果萃取液。 該基底組份為-選自下列群组中的物質：水、甜杏仁 由荷荷g油、葡萄子油、月見草油、玫瑰軒油、小麥胚 牙油、鱷梨油、薏仁油、茶子油，及此等的一組合。 較佳地配合使用需求及所選用的基底組份種類與調 配比例’可將该應用產品製成一選自下列群組中的產品型 式：：劑、油劑、乳液及膏體’以供皮膚外用使用。 田將該應用產品製成水劑型式時，該基底組份是選用 水’且該主要組份與該基底組份的混合比例為1 : 1〜3。並 能將其裝於喷瓶内以便於噴於患部使用。 當將该應用產品油劑或膏體型式時，則可方便直接塗 201109025 抹患部皮膚’此時’所選用的基.底組份則為—選自下列群 組中的物質：甜杏仁油、荷荷爸油、葡萄子油、月見草 油、玫瑰籽油、小麥胚芽油、鱷梨油、薏仁油、茶 及此等的一組合。 ' 此外，該應用產品還可包含一與該主要組份、基底組 份相混合的乳化劑，並將該應用產品製成乳液型式，同樣 有方便塗抹的功能。 值得說明的是’本發明能夠針對諾麗果萃取液提出1 應用於皮膚的效果主要是基於發明人曾在採收諾麗果時; 部被毛毛蟲螫傷，在處理熟爛諾麗果後，手部疼痛感奇績 /肖失，因而發現諾麗果中含有止癢效果的成分，進而考慮 利用諾麗果萃取液改善各種皮膚不適症狀的可能性。並以 此發展出提取該諾麗果中有效成分的製法，由.該製法除了 製得適合皮膚使用的諾麗果萃取液外，還可進一步將該諾 麗果萃取液發展為可供一般皮膚外用的應用產品。 下列二個具體例是將第一較佳實施例所製得的諾麗果 萃取液’分別與甜杏仁油與乳化劑，或水依預定的體積比 例5周配成不同應用產品後，再分別以該應用產品塗抹於不 同患部皮膚一段時間後所呈現的效果。 <具體例一（昆蟲咬傷）> 將甜杏仁油：乳化劑：諾麗果萃取液以15 : 5 : 80體 積比調製成乳液狀的一應用產品a，每1 _2小時對患部皮膚 塗擦一次該應用產品a。 參閱附件一 ’照片（A-1)為剛被昆蟲咬傷的情況，照片 201109025 (Μ為以該諾麗果萃取液所調製的應用產品乂塗㈣過^ Γ二的情形’可看出紅腫現象明顯減輕且沒有因難耐劇 盘轨it的痕跡，此外，亦發現塗擦經過1小時後，疼感 ^、”、、感已明顯減輕。 <具體例二（異位性皮膚炎）> 調製與<具體例一〉相同的應用產品a 皮膚塗擦一次該應用ga。 ^ °' 參閱附件二，照片㈣為異位性皮膚炎發作時的皮膚 狀況’照片(B-2)為以該諾麗果萃取液所調製的應用產品& =察經^!天後的情形，亦可看出皮膚的紅腫症現象明顯 1輕且患部皮膚同樣沒有被抓過的痕跡，且在塗擦後工小 時受試者的癢感m此也沒#因搔_耐而 跡或傷口。 & <具體例三（蓴麻療）> 將諾麗果萃取液：水以1 : 調製成水劑型式的一應用產品b 次該應用產品b。 1之體積比例（或重量比例） ，每小時對患部皮膚塗擦一 多閱附件二，如、片（c_ 1)為蓴麻療發作時的皮膚狀況， 照片（C-2)為以該諾麗果萃取液調製的應用產品b塗擦經過 1〇〇分鐘後的情形，亦可看出皮膚的紅腫痕跡明顯減少甚至 已為乎4失’且在塗_ 3〜5分鐘後，受試者即感到疼感消 失，因此也沒有因搔癢難耐而抓過的痕跡或傷口。 、根據前述三個具體例的結果，說明將含有諾麗果萃取 液的應用產品使用在皮膚上，確實能有效減輕紅、腫、 10 201109025 熱、瘪等症狀，進而改善患部皮膚的不適，顯示本發明該 諾麗果萃取液，及由其所製成的應用產品極適合供皮膚外 用。 值得一提的是，除了用於上述的皮膚症狀外，經研究 發現該諾麗果萃取液的應用產品實質上可應用於一選自下 列群組中的皮膚症狀：異位性皮膚炎、蓴麻疹、痱子、昆 蟲叮咬傷，及汗斑之皮膚。除了可快速減輕搔癢症狀外，201109025 VI. Description of the invention: [Technical field of invention] Method and application product [Prior Art] The present invention relates to a plant extract and a method for preparing the same, and particularly to a non-available noni Fruit extract and its noni-...the scientific name of Morindacitrif〇lia, belonging to the genus Rubiaceae (Rubiaceae), mainly distributed in the Pacific Ocean, Asia, Australia, Hawaii and Polynesia. Islands. Noni plants have medicinal ingredients from the fruit, seeds, flowers, bark 'tree stems and roots themselves. When the local residents of Tahiti are uncomfortable, they often directly squeeze the noni fruit into juice, or will be noni Leaves, seeds, roots, etc. are dried and ground into powder, or boiled and boiled. For a long time, Noni has been considered to have magical medical effects. When the ripe fruit is harvested, it is washed and dried, placed in a closed container, and taken by natural fermentation. In addition, it can be dried and ground into a powder, which is said to have an enhanced endocrine system, detoxification, anti-cancer and skin disease equivalent. In view of the special effects of Noni fruit in eating, many academic papers have been published at home and abroad. Although the 'Nanuli plant is rich in nutrients and is a plant with a very high value of 2 彳, but it is still used in food or oral administration, the physiological function of Noni fruit and its effect on the human body. The mechanism and biochemical knowledge and Xuxiang's research and development (4), ·, still have the need to continue to use the new use of non-fruit. DISCLOSURE OF THE INVENTION 201109025 Accordingly, an object of the present invention is to provide a method for preparing a noni fruit extract which extracts an active ingredient from a fruit, and which is a gentleman's skin. Therefore, the preparation method of the Euphorbia extract of the present invention comprises the steps of: (1) washing a predetermined amount of the mature noni fruit, and then drying to obtain a noni dried fruit raw material; (9) soaking the dried fruit raw material with a solvent to obtain a solvent Submerging the dried fruit material and allowing it to stand for more than 7 days to obtain a noni fruit impregnation composition; (out) immersing the composition with a (four) component having a predetermined pore size to obtain a crude extract; (4) adding - a predetermined 4 aqueous solution to the crude extract and adjusting the pH of the crude extract to be weakly acidic to neutral to obtain a final noni fruit extract, the noni fruit extract of the present invention The beneficial effect of the preparation method is that the crude extract of Noni can be obtained by dissolving a/package, and then the acid value of the crude extract is adjusted to be close to human skin, and the skin can be obtained. The fruit extract has the characteristics of being easy to manufacture and having high practical value. Further, the present invention also provides a noni fruit extract which is prepared by a wire method and which is suitable for improving skin discomfort. The beneficial effect of the noni fruit extract of the invention is that the extract can be close to the acidity value of the human skin, and the noni fruit contained therein can be dissolved, which can effectively alleviate the symptoms of skin discomfort and can The skin quickly restores the appearance of Zhengwei, and in addition, since the extract source is a natural substance, it is not easy to cause adverse side effects' and has an application value that can be developed into a skin external product. 201109025 Preferably, the present invention further provides an application product of Noni fruit extract prepared by using the noni fruit extract as a main component and which can be conveniently used. The application product of the noni fruit extract contains a main component and a base component which are mixed in a predetermined ratio. The main component is the noni fruit extract obtained from the above process. The base component is a material selected from the group consisting of water, sweet almond oil, jojoba oil (j〇j〇ba 〇il), grape seed oil, evening primrose Oil (evening primr〇se 〇ii), rosehip oil, wheat germ oil (wheat 〇π), avocado oil)) j〇bs tears, tea seed Oil), and a combination of these. The beneficial effects of the application product of the noni fruit extract of the invention are as follows: the non-nucleus extract is used as the main component and the base component can be used to prepare different types of water agent, oil agent emulsion and paste. The product can be diluted to a suitable concentration for the user to directly spray or apply. Since the application product is made of natural substances, it is less likely to cause adverse reactions to the skin compared to other chemical synthetic emulsions or poor bodies. The invention has the characteristics and advantages that the use effect is good and the side effects are not easily generated. The above and other technical contents, features and effects of the present invention will be apparent from the following detailed description of the preferred embodiments. Referring to Figure 1, a first preferred embodiment of the process for making a noni fruit extract of the present invention comprises the following steps: 201109025 Step 101 S Harvesting the mature noni fruit f and placing a predetermined amount of Noni fruit After washing with water and drying, the mixture is allowed to stand for fermentation and then dried to obtain a raw material of Noni dried fruit. Because Noni contains high amounts of sputum, it does not need to add other substances to promote fermentation, and it can be fermented by itself after standing. In this case, the non-negative fermentation may be carried out without drying, and the non-dried dried fruit material may be directly dried after washing, but the dissolution of the active ingredient may be increased in the subsequent extraction process by standing fermentation. In step 102, adding vinegar to the raw material of the dried fruit is preferred to enable the wrong liquid to submerge the raw material of the dried fruit. If the vinegar does not submerge the raw material of the dried fruit, it is preferred to make the surface of the dried raw material covered with vinegar. In the present embodiment, the weight ratio of the dried fruit material to the vinegar is 1:2, and the time for immersing the dried fruit material in the vinegar solution is preferably one day. Because the vinegar service test value is about pH3~4, it is similar to the acid value of Noni's, which can further increase the dissolution amount of the active ingredient in the noni fruit. And inhibit the growth of microorganisms. Step 103: immersing the dried fruit raw material treated by the step 1〇2 in a solvent to make the solvent submerged the dried fruit raw material and letting it stand for more than 7 days to obtain a noni fruit-impregnated composition, and effective in the noni fruit. The ingredients are released into the solvent. The weight ratio of the dried fruit material to the solvent is preferably 丄: 13 . In addition, the type of solvent used for the soaking of the dried fruit material should not be limited, as long as the solvent capable of extracting the active ingredient in the noni fruit can be used, in the present example, 'in order to reduce chemical residue and avoid using chemistry The substance causes undesirable side effects' and water is selected as the solvent, and the weight ratio of the dried fruit material to water is substantially 1: i. When this step is carried out, since the high concentration of noni fruit is dissolved in the vinegar added in 201109025 in step 1〇2, the vinegar does not need to be poured out in this step but directly added water. Step 104 is to filter the noni fruit impregnation composition by a filter element having a predetermined pore size to obtain a crude extract, which is filtered by cotton or gauze. a solid matter portion, and obtaining the crude extract 0. Step 105 is to add a predetermined amount of an alkaline solution to the crude extract and adjust the pH of the crude extract to be weakly acidic to neutral to obtain a final, Fruit extract. Therefore, the alkaline solution used is triethanolamine, and in order to make the extract more suitable for skin parts of the body, the pH of the crude extract is adjusted to pH 5.5 which is close to the average skin acid value. ~7. In order to make the noni fruit extract suitable for external use, diethanolamine is widely used in various types of sacrificial agents and skin care products, for example, skin washing, eye gel, moisturizing, shampooing The P equilibrium d in the formulation and the like therefore 'the pH of the crude extract is also adjusted here using triethanolamine. _ 2' is the method for preparing the noni fruit extract of the present invention - the second preferred embodiment 'the second preferred embodiment steps. 2 〇 1, 2 () 4 and 2 〇 5 respectively Steps (8), 1G4 & (10) of the preferred embodiment are the same and will not be described. The main difference is the processing of steps 202 and 203. Step 202 is to use the sound of the & ^co / a material to wash the dried fruit of the original dried fruit 去 2: 2, the water is used as a solvent to soak the dried fruit original processed by step 202, in the present application Example t, the weight ratio of the dried fruit raw material to water ^ 201109025 1 : 3, that is, a total of 3 parts by weight of the dry weight raw material of the glutinous weight of the raw material, the water of the 3 parts of the summer portion will be added in 2 times, and 2 times After 1 day between the intervals, 'the same is allowed to stand for more than 7 days, so that the active ingredients in the noni fruit are released into the water. A, through the second preferred embodiment, a noni fruit extract having an appropriate pH and containing an active ingredient in noni fruit suitable for external use on the skin can also be obtained. The noni fruit extract is prepared by the method of D Xuan first and second preferred embodiments, and can be used for immersing the skin after being diluted directly with water, and can be further combined with a specific base component to make it convenient for general users. Applied products for coating. . A preferred embodiment of the application product of the genio juice extract comprises a major component and a base component which are mixed in a predetermined ratio. . The major group of scars is obtained from the noni fruit extract prepared by the method of the first preferred embodiment or the second preferred embodiment. The base component is - a substance selected from the group consisting of water, sweet almonds from jojoba oil, grape seed oil, evening primrose oil, rose oil, wheat germ oil, avocado oil, coix seed oil, tea Oil, and a combination of these. Preferably, the application requirements and the selected base component type and blending ratio ' can be used to make the product into a product type selected from the group consisting of: agents, oils, lotions, and pastes for the skin. For external use. When the application product is formulated into a water dosage form, the base component is selected from water and the mixing ratio of the main component to the base component is 1:1 to 3. It can be placed in a spray bottle to facilitate spraying on the affected area. When the application product is in the form of oil or paste, it is convenient to directly apply 201109025 to the skin of the affected area. The base component selected at this time is - a substance selected from the group consisting of sweet almond oil, Jojoba oil, grape seed oil, evening primrose oil, rose seed oil, wheat germ oil, avocado oil, coix seed oil, tea and a combination of these. In addition, the application product may further comprise an emulsifier mixed with the main component and the base component, and the application product is made into an emulsion type, and has the function of facilitating application. It is worth noting that 'the invention can be applied to the noni fruit extract. 1 The effect on the skin is mainly based on the inventor's time when the noni fruit was harvested; the caterpillar was bruised and treated after the cooked noni fruit. The pain in the hand is lost/disappeared, so I found that the noni fruit contains anti-itching ingredients, and then considers the possibility of using Nori extract to improve various skin discomfort symptoms. In order to develop the method for extracting the active ingredient in the noni fruit, the method can further develop the noni fruit extract into general skin in addition to the noni fruit extract suitable for skin use. External application products. The following two specific examples are that the noni fruit extract prepared in the first preferred embodiment is separately combined with the sweet almond oil and the emulsifier or water according to a predetermined volume ratio for 5 weeks, and then separately The effect exhibited by the application product after being applied to the skin of different affected parts for a period of time. <Specific Example 1 (Insect bite)> Sweet almond oil: emulsifier: Noni fruit extract is prepared into an emulsion-like application product a at a volume ratio of 15:5:80, and the skin of the affected part is rubbed every 1 to 2 hours. The application product a. See Attachment 1 'Photo (A-1) for the case of being bitten by insects, photo 201109025 (Μ is the application of the product prepared by the extract of the noni fruit extract (4) over the condition of ^ Γ 2' can be seen redness Significantly reduced and there is no trace of the difficulty of the screen track it. In addition, it is also found that after 1 hour of rubbing, the pain, "," feeling has been significantly reduced. <Specific example 2 (atopic dermatitis) > Modulation The same application product as <Specific Example 1 a. Apply the skin once to the application ga. ^ °' See Annex II, photo (4) for the skin condition at the onset of atopic dermatitis 'Photo (B-2) for the promise The application product prepared by the extract of Liguo extract & = the condition of the ^ ^ ^ day, can also be seen that the skin redness and swelling phenomenon is obvious 1 light and the affected part of the skin is also not caught, and after the rubbing hours The subject's itching sensation m is also not #因搔_resistant traces or wounds. &<Specific Example 3 (莼麻疗)> Noni fruit extract: water with 1: modulating into a water dosage form One application product b times the application product b. 1 volume ratio (or weight ratio), each small Apply a lot of rubbing to the skin of the affected part. For example, the piece (c_1) is the skin condition at the time of the ramie treatment. The photo (C-2) is the application product b prepared by the noni fruit extract. After a minute of sputum, it can be seen that the redness and swelling of the skin is significantly reduced or even has been lost. And after _ 3~5 minutes, the subject feels pain disappearing, so there is no scratching due to itching. Traces or wounds. According to the results of the above three specific examples, the application of the product containing Noni fruit extract on the skin can effectively alleviate redness, swelling, and other symptoms such as heat and phlegm. The discomfort of the skin of the affected part shows that the noni fruit extract of the present invention and the application product made therefrom are very suitable for external use on the skin. It is worth mentioning that, in addition to the above-mentioned skin symptoms, the research has found that the Novo The application of the extract of Liguo extract can be applied to a skin symptom selected from the group consisting of atopic dermatitis, urticaria, lice, insect bites, and skin of sweat stains. Like outside,
也可使皮膚恢復正常外觀，據此可說明本發明應用產品極 適合供外膚外用。 知納上述，本發明諾麗果萃取液及g製法與應用.產 品，可獲致下述的功效及優點，故能達到本發明的目的： 、 本發明以溶劑浸泡的方式就能取得諾麗果粗萃取 液，再將.該粗萃取液的酸驗值調整為與人體肌膚相接近， 就能製得適用於皮膚之最終的諾麗果萃取液，經實驗證實 經本發明製法所製得的諾麗果萃取液確實能提供改善皮膚 :效果/顯示該製法不但容易製造，且確實能取得諾麗果 中的有效成分而具實用價值。 —、本發明製法中用於浸泡該諾麗乾果原料的溶劑可 =水，整個製程所用的醋液與乙醇等都是對人 二：安全的物質’由此所製得的諾麗果萃取液相 會危害人體健康的化學物質，而具有不易產生副 作用及使用上較安全的特性。 的應用產品使用在患部皮 解療感的效果，且針對不 二、將本發明諾麗果萃取液 膚上時，能在短時間内就達到緩 201109025 同的皮膚症狀，都能在一 箱6 , 月b在 #又預疋時間内消除症狀而無不良 田丨·!作用產生，顯示太私日月却；盛田_ 不士月祐簏果卒取液’及由其所製得的 應用產品適於供皮膚外用，，丄& θ 贗卜用且對大多數皮膚不適症狀都能 提供有效而良好的改善效果。 准以上所述者，僅為本發明之較佳實施例而已，當不 能以此限定本發明實狀範圍m依本發”請專利 範圍及發明說明内容所作之簡單的等效變化與修飾，皆仍 屬本發明專利涵蓋之範圍内。 【圖式簡單說明】 圖1是本發明諾麗果萃取液的製法一第一較佳實施例 的流程圖；及 圖2是本發明諾麗果萃取液的製法一第二較佳實施例 的流程圖。 附件一：說明在昆蟲咬傷的皮膚上塗佈本發明諾麗果 萃取液的應用產品前後皮膚外觀的比較照片。 附件二：說明在異位性皮膚炎的皮膚上塗佈本發明諾 麗果萃取液的應用產品前後皮膚外觀的比較照片。 附件二：說明在蓴麻療的皮膚上塗佈本發明諾麗果萃 取液的應用產品前後皮膚外觀的比較照片。 12 201109025 【主要元件符號說明】It is also possible to restore the skin to a normal appearance, and accordingly, it can be explained that the application product of the present invention is extremely suitable for external use of the outer skin. In view of the above, the noni fruit extract and the g method and application product of the present invention can achieve the following effects and advantages, so that the object of the present invention can be achieved: The present invention can obtain the noni fruit by solvent soaking. The crude extract, and the acid value of the crude extract is adjusted to be close to the human skin, and the final noni fruit extract suitable for the skin can be obtained, and the preparation obtained by the method of the present invention is confirmed by experiments. Liguo extract does provide improved skin: the effect / shows that the method is not only easy to manufacture, but also has practical value in obtaining the active ingredients in noni fruit. - The solvent used for soaking the raw material of the noni dried fruit in the process of the present invention can be = water, and the vinegar and ethanol used in the whole process are both human: safe substance 'The resulting noni fruit extract It has chemical properties that are harmful to human health, and has characteristics that are less prone to side effects and safer to use. The application product uses the effect of decongesting the skin in the affected part, and when it is applied to the skin of the noni fruit extract of the present invention, it can achieve the same skin symptoms as the 201109025 in a short time, and can be in a case of 6 , Month b in the pre-emptive time to eliminate the symptoms and no bad Tian Hao ·! The role is produced, showing too much sun and the moon; Shengtian _ not a month of the moon and the fruit of the stroke liquid 'and its application products It is suitable for external use on the skin, and it can provide effective and good improvement for most skin discomfort symptoms. The above is only the preferred embodiment of the present invention, and the simple equivalent changes and modifications made by the scope of the invention and the description of the invention are not limited thereto. 1 is a flow chart of a first preferred embodiment of the method for preparing a noni fruit extract of the present invention; and FIG. 2 is a noni fruit extract of the present invention. A flow chart of a second preferred embodiment of the method of manufacture. Annex I: A comparative photograph showing the appearance of the skin before and after application of the noni fruit extract of the present invention on the skin of an insect bite. Annex 2: Description in the atopic A comparative photograph of the appearance of the skin before and after application of the noni fruit extract of the present invention on the dermatological skin. Annex 2: Description of the appearance of the skin before and after application of the noni fruit extract of the present invention on the skin of the ramie treatment Comparison photo. 12 201109025 [Main component symbol description]