TW201106985A - Food formulation used in anti-oxidation, anti-aging, and anti-inflammation, and manufacturing method thereof - Google Patents
Food formulation used in anti-oxidation, anti-aging, and anti-inflammation, and manufacturing method thereof Download PDFInfo
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- TW201106985A TW201106985A TW98127771A TW98127771A TW201106985A TW 201106985 A TW201106985 A TW 201106985A TW 98127771 A TW98127771 A TW 98127771A TW 98127771 A TW98127771 A TW 98127771A TW 201106985 A TW201106985 A TW 201106985A
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- extract
- oxidation
- aging
- inflammatory
- food
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
201106985 六、發明說明： 【發明所屬之技術領域】 本發明是有關於一種食品配方及其製造方法， 特別是有關於一種用於抗氧化、抗老化與抗發炎之 食品配方及其製造方法。 【先前技術】 現今，防老抗老觀念已成為全民運動，專家指 出，許多研究將老化元凶指向「自由基」。體内細胞 需要氧氣才能正常運作，但是，在利用氧氣的過程 中會產生有害的副產品，也就是所謂的「自由基」。 壓力、緊張、焦慮、鬱悶等，以及吸菸，酗酒或接 觸不當的光照射，環境汙染或不正當使用化學藥 物，亦會使自由基增加，加速體内氧化壓力，導致 細胞結構和功能損害，嚴重的話，更會使體内造成 發炎狀態，因此，想要抗老化，就要先做好抗氧化。 如何清除體内過多的自由基，將是值得重視的課題。 身體内可產生自由基清除者，能夠抑制自由基 的形成。這些清除者為特殊酵素具有中和自由基的 功能，像是超氧歧化酶（superoxide dismutase, SOD)、甲硫胺酸還原酶（methione reductase)、過 氧化氫酶（catalase)、榖胱甘肽過氧化酶（glutathione peroxidase)。隨著年紀的增長，身體製造這些酵素 201106985 的=力逐漸降低，故需要由飲食中攝取天然的抗氧 =其例如維他命A、C、E及硒，以協助體内清除 自由基。然而，現今社會因外食的人數逐年遞辦， 難以透過飲食中攝取足夠的抗氧化劑，因此 額外補充複方的抗氧化萃取食品配方，既可方‘ 攝取足夠量的抗氧化劑，又因複方的組成特色，更 可全方位地達到捕捉體内自由基的功效。 【發明内容】 明之其中-目的就是在提供一種用於抗 抗發炎之食品配方，其每-單位係包 括田3白藜盧醇之葡萄皮與葡萄葉約150〜250臺 1、：巧取物約」00〜200毫克、葡萄籽萃取_ 笔克、石榴萃取物約20〜40毫克、山苦瓜萃 取物約1〇〜30毫克、金蓋花萃取物 二卒 山好；取物5〜15毫克、萊姆果C約5〜15g及 松树皮萃取物約1〜1 〇毫克。 化、—目的就是在提供—種用於抗氧 =一杬發炎之食品配方之製造方法，1步 藥將富含白藜產醇之葡萄皮與葡萄葉、山 2取物、葡萄料取物、石料取物、山苦 取物'金盞花萃取物、山桑子萃取物、萊姆果 201106985 ‘松樹皮萃取物溶解於水溶液中，取得—混合溶液。 將此混合溶液經由冷;東乾燥、噴霧乾燥或真空乾 方式處理’以製得粉末狀之食品配方4藉由賦形 劑將此粉末狀之食品配方製成膠囊、片劑或錠 劑型。其中’每一膠囊、片劑或錠劑係包括葡萄皮 與葡萄葉約150〜250毫克、山藥萃取物約⑽〜 毫克、葡萄籽萃取物約40〜80 4克、石福萃取物約 20〜40毫克、山苦瓜萃取物約1〇〜3〇毫 h取物約1〇,毫克、山桑子萃取物約5克4盒克化 萊姆果C約5〜15毫克及松樹皮萃取物約丨〜1〇毫克。 承上所述，依本發明之用於抗氧化、抗老化盥 抗發炎之食品配方，其可具有一或多個下述優點'、 (1) 本發明所提供之用於抗氧化、抗老化與抗發炎之 食品配方係取自純天然的成分，易於人體所吸 收且無副作用。 (2) j體服用本發明之用於抗氧化、抗老化與抗發 炎之食品配方可有效捕捉體内過多的自由基， 達到抗氧化、抗老化與抗發炎的功效。 (3) 藉由每日服用本發明之用於抗氧化、抗老化與 抗發k之食品配方，能夠顯著地降低體内的發 炎指數。 201106985 【實施方式】 心1明t藉由下述實施例及實驗實施例進一步 坪細玩明，然而其並非用於限制本發明。 施例 方之組忐 發炎之含品 配 "Π較佳情況下，其用於抗氧化、抗老化與 抗么火之艮品配方係為粉末狀，每一單位主要成分 係包括富含㈣蘆醇之葡萄皮與葡萄葉約150〜250 毫克、山藥萃取物、約100〜細亳克、葡萄杆萃取物 〜80亳克、石福萃取物約2〇〜4〇毫克、山苦瓜 卒取物約10〜30毫克、金盞花萃取物約1〇〜3〇毫克、 山桑子萃取物5〜15毫克、萊姆果c約5〜15毫克及 松樹皮萃取物約1〜W毫克。其配方成分更可包括香 料與果汁粉，以增加其嗜口性。其中 皮與葡萄葉係因富含大量的白蓉蘆醇，故能調節身 體的代謝、保護DNA、抑制發炎，進而達到抗氧化、 f老化與抗發炎的功效。其他的成分更為良好的抗 氣化劑，與白藜蘆醇之間具有協同作用，將抗氧化 機制達到最佳狀態。像是松樹皮萃取物内含有豐富 =一氫槲皮素，係為強抗氧化劑；石榴萃取物内亦 备含鞣花酸’亦能捕捉自由基。此外，該抗氧化、 201106985 抗老化與抗發炎之食品配方除可為粉末狀外，亦可 製成顆粒狀或液體狀，而每一單位係以一膠囊、片 劑、錠劑、包裝袋或瓶為準。每天服用之劑量可為 1^4單位。另外，更可包括一醫藥可接受之賦形劑 或载體，此賦形劑係可選自由調味劑、增甜劑、防 腐劑、螯合劑、等滲透劑、潤滑劑、錠劑佐劑、著 色劑、保濕劑、結合劑以及醫藥可相容载劑所組 之群組中。 置^L2:用於抗老化與抗發炎之食a 复之製造方法 ^請參閱第1圖，其係為本發明之用於抗氧化、 抗老化與抗發炎之食品配方之製造方法，其可包 括：步驟si卜將葡萄皮與葡萄葉萃取物、山藥萃 取物、葡萄籽萃取&、石料取物、山苦瓜萃取物 約三金盞花萃取物、山桑子萃取物、萊姆果及松樹 皮萃取物及綜合維生素溶解於水溶液中，取得一混 合溶液。步驟S12,將此混合溶液經由冷凍乾燥、 嘴霧乾㈣真空錢方式處理，以製得粉末狀之食 品配方’以及步驟S13’再藉由賦形劑將此粉末狀 之食品配方製成膠囊、片劑或錠劑等劑型。其中， 食品配方的每一單位係包括富含白藜蘆醇之’葡萄皮 與葡萄葉約150〜250毫克、山藥萃取物約謂〜2〇〇 201106985 毫克、葡萄籽萃取物約40〜80毫克、石榴萃取物約 20〜40毫克、山苦瓜萃取物約10〜30毫克、金盞花 萃取物約10〜30毫克、山桑子萃取物5〜15毫克、萊 姆果C約5〜15毫克及松樹皮萃取物約1〜10毫克， 且食品配方中白藜蘆醇的含量約佔葡萄皮與葡萄葉 重量的十分之一；金盞花萃取物之葉黃素含量更佔 總重量的五分之一。其更可進一步包括加入一賦形 劑，以將粉末狀之食品配方製成膠囊、片劑或錠劑 劑型之步驟，且所製備之混合溶液更可包括香料與 果汁粉。每一單位係以一膠囊、片劑、鍵劑、包裝 袋或瓶為準，且每天服用之劑量可為1~4單位。 實施例3 :用於抗氣化、抗老化與抗發炎之食品配 方之自由基清除測試 依Arnao (1996)等之方法並做修飾。將0.25 mL peroxidase (4.4 U/mL)、0.25 mL 2,2-azino-bis [3-ethyl- benzthiazoline- 6-sulfonic acid] (ABTS, 100 β M) 、0.25 mL H202 (50 # M)以及 1.5 mL 去離子水混合均勻，反應10分鐘產生安定的藍綠色 ABTS.+陽離子自由基後，加入不同濃度之測試樣 品（抗氧化、抗老化與抗發炎之食品配方混合溶液） 反應10分鐘，測734 nm吸光值。另外，以不同濃度 的Trolox清除ABTS.+陽離子自由基之能力作一 清除率標準曲線，檢測樣品清除ABTS ·+陽離子自 201106985 由基的能力，以Trolox濃度（mM)來表示，其實驗 結果如表一所示，抗氧化、抗老化與抗發炎之食品 配方混合溶液的濃度越高，則總抗氧化能力越高， 清除自由基的能力越強。 表一 測試樣品（抗氧化、抗老化與抗發 炎之食品配方）濃度&g/mL) Trolox equivalent antioxidant capacity (TEAC, mM) 50 0.076 ±〇.〇〇l 25 0.043 ±0.001 0 (空白組） 0.002 ±0.001 實施例4 :用於抗氣化、抗老化與抗發炎之食品配 方之抗發炎試驗 以 LPS(lipopolysaccharide)使老鼠 RAW264.7 的 巨噬細胞誘發產生大量誘發型一氧化氮合成酶 iNOS(inducible nitric oxide synthase)的表現，進而 合成大量的一氧化氮（nitrite，NO)。首先，先將 RAW264.7巨噬細胞培養於24 well中，使其細胞密 度為2xl06，培養24小時後，依照實驗加入不同濃 度的抗氧化、抗老化與抗發炎之食品配方混合溶液 後，再加入 LPS(lipopolysaccharide，100ng/mL)，處 理24小時後，依據Griess試驗方法進行nitrite定 量，而後以酵素免疫分析儀（Enzyme-linked immunosorbent assay plate reader， ELISA reader) ， 於波長 201106985 540nm下測其吸光值，其實驗結果如表二所顯示， 抗氧化、抗老化與抗發炎之食品配方混合溶液的濃 度越高，越能降低iNOS合成NO的能力，降低NO 的濃度，以達到抗發炎的效果。 表二 測試樣品（抗氧化、抗老化與抗發 炎之食品配方）濃度（pg/mL) Nitrite(NO)吸光 OD值 50 0.89 ± 0.02 25 2.56 ±0.05 0 (空白組） 0.02 ±0.01 以上所述僅為舉例性，而非為限制性者。任何 未脫離本發明之精神與範疇，而對其進行之等效修 改或變更，均應包含於後附之申請專利範圍中。 【圖式簡單說明】 第1圖係為本發明之用於抗氧化、抗老化與抗 發炎之食品配方之製造方法之流程圖。 【主要元件符號說明】 S11-S13 :步驟流程圖。201106985 VI. Description of the Invention: [Technical Field] The present invention relates to a food formulation and a method of manufacturing the same, and more particularly to a food formulation for anti-oxidation, anti-aging and anti-inflammatory, and a method of manufacturing the same. [Prior Art] Nowadays, the concept of anti-aging and anti-aging has become a national movement. Experts point out that many studies point the aging culprit to "free radicals." Cells in the body need oxygen to function properly, but in the process of using oxygen, harmful by-products are produced, which are called "free radicals". Stress, tension, anxiety, depression, etc., as well as smoking, alcohol or improper exposure to light, environmental pollution or improper use of chemical drugs, will also increase free radicals, accelerate oxidative stress in the body, resulting in damage to cell structure and function, If it is serious, it will cause inflammation in the body. Therefore, if you want to resist aging, you must first do antioxidants. How to eliminate excessive free radicals in the body will be a topic worthy of attention. A free radical scavenger can be produced in the body to inhibit the formation of free radicals. These scavengers are special enzymes that neutralize free radicals, such as superoxide dismutase (SOD), methione reductase, catalase, and glutathione. Peroxidase (glutathione peroxidase). As the age grows, the body's ability to make these enzymes 201106985 gradually decreases, so it is necessary to take natural antioxidants from the diet = such as vitamins A, C, E and selenium to help the body clear free radicals. However, in today's society, the number of people who eat outside is being transferred year by year. It is difficult to get enough antioxidants through the diet. Therefore, the supplement of the compound antioxidant extract food formula can not only take a sufficient amount of antioxidants, but also the composition of the compound. It can also achieve the effect of capturing free radicals in the body in all directions. SUMMARY OF THE INVENTION The purpose of the present invention is to provide a food formulation for resisting inflammation, each of which comprises about 150 to 250 sets of grape skins and grape leaves of Tian 3 white glutinous alcohol. About 00~200 mg, grape seed extract _ pen gram, pomegranate extract about 20~40 mg, mountain bitter gourd extract about 1 〇~30 mg, golden cover flower extract is good; take 5~15 mg , Lyme C is about 5~15g and pine bark extract is about 1~1 〇mg. The purpose is to provide a method for the manufacture of a food formula for anti-oxidation = inflammation. The 1-step medicine will be rich in grape skin and grape leaves, and the grape extract, grape extract. , stone extract, mountain bitter extract 'calendula extract, mulberry extract, lime fruit 201106985' pine bark extract dissolved in aqueous solution, obtained - mixed solution. The mixed solution is subjected to cold, east drying, spray drying or vacuum drying to produce a powdered food formulation 4 which is formulated into a capsule, tablet or lozenge form by an excipient. Among them, 'each capsule, tablet or lozenge includes about 150~250 mg of grape skin and grape leaves, about (10)~mg of yam extract, about 40~80 4 g of grape seed extract, about 20~ of Shifu extract 40 mg, extract of Momordica charantia L. about 1 〇~3 〇 millih, about 1 〇, milligrams, mulberry extract, about 5 grams, 4 boxes of gramified lime fruit C, about 5 to 15 mg, and pine bark extract. ~1〇 milligrams. According to the present invention, the anti-oxidation, anti-aging, anti-inflammatory food formulation according to the present invention may have one or more of the following advantages. (1) The present invention provides anti-oxidation and anti-aging effects. The anti-inflammatory food formula is derived from pure natural ingredients and is easily absorbed by the body without side effects. (2) The j body taking the anti-oxidation, anti-aging and anti-inflammatory food formula of the present invention can effectively capture excessive free radicals in the body, and achieve anti-oxidation, anti-aging and anti-inflammatory effects. (3) The inflammatory index in the body can be remarkably lowered by taking the daily anti-oxidation, anti-aging and anti-k food formulation of the present invention. 201106985 [Embodiment] The present invention is further illustrated by the following examples and experimental examples, which are not intended to limit the present invention. In the case of the formula, the inflamed product is blended with "Π, preferably, the anti-oxidation, anti-aging and anti-fire formula is powdery, and the main components of each unit are rich (4) Resveratrol grape skin and grape leaves about 150~250 mg, yam extract, about 100~ fine gram, grape stem extract ~80 gram, Shifu extract about 2 〇~4 〇mg, mountain bitter gourd About 10~30 mg of the substance, about 1〇~3〇 mg of the calendula extract, 5~15 mg of the mulberry extract, about 5~15 mg of the lime fruit c and about 1~W mg of the pine bark extract. Its formula can also include spices and juice powder to increase its palatability. The skin and grape leaf are rich in white rosin, which can regulate body metabolism, protect DNA, inhibit inflammation, and achieve anti-oxidation, f-aging and anti-inflammatory effects. Other ingredients with better anti-gasification agents have synergistic effects with resveratrol to optimize the antioxidant mechanism. For example, the pine bark extract is rich in phenanthrene, which is a strong antioxidant; the pomegranate extract also contains ellagic acid, which also captures free radicals. In addition, the antioxidant, 201106985 anti-aging and anti-inflammatory food formula can be in the form of granules or liquids in addition to powder, and each unit is in a capsule, tablet, lozenge, package or The bottle is subject to change. The daily dose can be 1^4 units. In addition, it may further comprise a pharmaceutically acceptable excipient or carrier which is optionally a flavoring agent, a sweetening agent, a preservative, a chelating agent, an osmotic agent, a lubricant, a lozenge adjuvant, A group of colorants, humectants, binders, and pharmaceutically compatible carriers. ^L2: a method for producing anti-aging and anti-inflammatory foods. Please refer to FIG. 1 , which is a method for producing a food formulation for antioxidant, anti-aging and anti-inflammatory according to the present invention. Including: step si b grape skin and grape leaf extract, yam extract, grape seed extract &, stone extract, mountain balsam extract about three calendula extract, mulberry extract, lime fruit and pine bark extract The compound and the multivitamin are dissolved in an aqueous solution to obtain a mixed solution. Step S12, the mixed solution is processed by freeze-drying, mouth-drying (4) vacuum method to prepare a powdered food formula 'and step S13', and then the powdered food formula is encapsulated by an excipient. Dosage forms such as tablets or lozenges. Among them, each unit of the food formula includes resveratrol-rich 'grape skin and grape leaves about 150~250 mg, yam extract about ~2〇〇201106985 mg, grape seed extract about 40~80 mg , pomegranate extract about 20~40 mg, mountain bitter gourd extract about 10~30 mg, calendula extract about 10~30 mg, mulberry extract 5~15 mg, lime fruit C about 5~15 mg and pine bark The extract is about 1~10 mg, and the content of resveratrol in the food formula is about one tenth of the weight of the grape skin and the grape leaf; the lutein content of the calendula extract is one-fifth of the total weight. It may further comprise the step of adding an excipient to formulate the powdered food product into a capsule, tablet or lozenge dosage form, and the mixed solution prepared may further comprise a fragrance and a juice powder. Each unit is based on a capsule, tablet, key, bag or bottle, and can be used in a dose of 1 to 4 units per day. Example 3: Free radical scavenging test for food formulations for anti-gasification, anti-aging and anti-inflammatory According to Arnao (1996) and the like. 0.25 mL peroxidase (4.4 U/mL), 0.25 mL 2,2-azino-bis [3-ethyl- benzthiazoline-6-sulfonic acid] (ABTS, 100 β M), 0.25 mL H202 (50 # M), and 1.5 Mix the mL deionized water evenly, react for 10 minutes to produce stable blue-green ABTS.+ cationic free radicals, add different concentrations of the test sample (antioxidant, anti-aging and anti-inflammatory food formula mixed solution) for 10 minutes, measure 734 Nm absorbance value. In addition, the ability to remove ABTS.+ cation free radicals with different concentrations of Trolox was used as a clearance standard curve to detect the ability of the sample to clear ABTS ·+ cations from 201106985. The concentration was expressed as Trolox concentration (mM). As shown in Table 1, the higher the concentration of the anti-oxidation, anti-aging and anti-inflammatory food formula mixed solution, the higher the total antioxidant capacity and the stronger the ability to scavenge free radicals. Table 1 Test sample (antioxidant, anti-aging and anti-inflammatory food formula) concentration & g / mL) Trolox equivalent antioxidant capacity (TEAC, mM) 50 0.076 ± 〇. 〇〇l 25 0.043 ± 0.001 0 (blank group) 0.002 ± 0.001 Example 4: Anti-inflammatory test for food formulations for anti-gasification, anti-aging and anti-inflammatory products LPS (lipopolysaccharide) induces macrophage RAW264.7 in mice to induce a large number of inducible nitric oxide synthase iNOS The performance of (inducible nitric oxide synthase), in turn, the synthesis of a large amount of nitric oxide (nitrite, NO). First, RAW264.7 macrophages were cultured in 24 wells to a cell density of 2xl06. After 24 hours of culture, different concentrations of anti-oxidant, anti-aging and anti-inflammatory food formula mixed solutions were added according to the experiment. LPS (lipopolysaccharide, 100 ng/mL) was added, and after 24 hours of treatment, nitrite was quantified according to the Griess test method, and then absorbance was measured at an wavelength of 201106985 at 540 nm by an enzyme-linked immunosorbent assay plate reader (ELISA reader). The experimental results are shown in Table 2. The higher the concentration of the anti-oxidation, anti-aging and anti-inflammatory food formula mixed solution, the lower the ability of iNOS to synthesize NO and the lower the concentration of NO to achieve anti-inflammatory effect. Table 2 Test sample (antioxidant, anti-aging and anti-inflammatory food formula) concentration (pg/mL) Nitrite (NO) absorbance OD value 50 0.89 ± 0.02 25 2.56 ±0.05 0 (blank group) 0.02 ±0.01 It is intended to be illustrative, not limiting. Any equivalent modifications or alterations to the spirit and scope of the invention are intended to be included in the scope of the appended claims. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a flow chart showing the manufacturing method of the anti-oxidation, anti-aging and anti-inflammatory food formulations of the present invention. [Main component symbol description] S11-S13: Step flow chart.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103355663A (en) * | 2012-03-30 | 2013-10-23 | 白藜芦醇作者生技研发有限公司 | Food formula for nourishing, maintaining and repairing various stem cells and preparation method thereof |
| CN103797127A (en) * | 2011-04-13 | 2014-05-14 | 株式会社爱茉莉太平洋 | Screening method for substances for inhibiting inflammatory skin aging |
| CN112890190A (en) * | 2019-11-19 | 2021-06-04 | 廖全祥 | Food composition for viscera care |
-
2009
- 2009-08-18 TW TW98127771A patent/TW201106985A/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103797127A (en) * | 2011-04-13 | 2014-05-14 | 株式会社爱茉莉太平洋 | Screening method for substances for inhibiting inflammatory skin aging |
| CN103797127B (en) * | 2011-04-13 | 2016-09-28 | 株式会社爱茉莉太平洋 | Method for screening substance for inhibiting inflammatory skin aging |
| CN103355663A (en) * | 2012-03-30 | 2013-10-23 | 白藜芦醇作者生技研发有限公司 | Food formula for nourishing, maintaining and repairing various stem cells and preparation method thereof |
| CN112890190A (en) * | 2019-11-19 | 2021-06-04 | 廖全祥 | Food composition for viscera care |
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