TW201043139A - Triazole compounds carrying a sulfur substituent III - Google Patents

Abstract

The present invention relates to novel triazole compounds of the formulae I and II as defined in the claims and description which carry a sulfur substituent, to agricultural compositions containing them, to their use as fungicides and to intermediate compounds used in the method of producing them.

Description

201043139 6. INSTRUCTIONS OF THE INVENTION: TECHNICAL FIELD The present invention relates to a novel triazole compound of the formula I and formula II having a sulfur substituent as defined below, an agricultural composition containing the same, which is The use of fungicides and intermediate compounds used in the preparation thereof. • [Prior Art] Controlling plant diseases caused by phytopathogenic fungi is extremely important for achieving high crop efficiency. Plant disease damage from ornamental crops, vegetable crops, field crops, cereals and fruit crops can result in a significant reduction in productivity and thus an increase in the price of the consumer. The triazolyl derivatives are described in DE 19520098, DE 19617282, DE 19620407, DE 19620590 and WO 97/43269. These compounds are used against harmful fungi. There is a continuing need for novel compounds that are more effective, less costly, less toxic, safer in the environment, and/or have different modes of action. SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide compounds having better fungicidal activity and/or better crop plant compatibility. Surprisingly, such targets can be achieved by the <3> azole compounds of the general formula I and II as defined below and by the agriculturally acceptable salts of the compounds I and II. Accordingly, the present invention relates to triazole compounds of formula I and formula II and their agriculturally acceptable salts, 147475.doc 201043139

Wherein L and L are independently selected from the group consisting of hydrogen, fluorine, bromine, iodine, and alkyl. a dentate group, a Cl_Ci oxy group, and a Ci_CiQ halogen oxy group; L2 and L3 are independently selected from the group consisting of hydrogen, a nutrient, c "Ci. Silk, Ci_Ci. a halogen group, a qc alkoxy group, and a Ci_Ci 烧 alkoxy The restriction strip 2 is L1, L2, L3 and at least one of them is not hydrogen; R and R are independently selected from hydrogen, Ci_Ci 〇 alkyl, Ci_Ci 〇 垸 Cl Cl Cl-Cl0 oxy and halogen氧基; R3 is selected from the group consisting of hydrogen, Cl_ClG alkyl, Ci_CiQ [fi alkyl, Ci_Ci decyloxy and Cl-C10 haloalkoxy; R is selected from hydrogen, CVC!. Alkyl, Cl_Ci 〇 haloalkyl , c2_Ci decyl, C2-C1G _ linkage, c2_CiG fast radical, decyl alkynyl, CyCiQ cycloalkyl, C3-C10 halocycloalkyl, phenyl, phenyl-Ci_c4 alkyl, of which the last two The phenyl moiety in the group may have 丨, 2, 3, 4 or 5 substituents, R8, and 5 members containing ruthenium, 2 or 3 heteroatoms selected from N, oxime and S as ring-shaped shells 46-membered saturated, partially unsaturated or aromatic heterocyclic ring wherein the group may have 1, 2 or 3 substituents R8; or in the case of 〇^ < If, also selected 147475.doc 201043139 from -C( =〇)R5, -C(=S)R, -S(〇)2R5, -CN, -P(=Q)R6r7, μ and Formula I II group,

Wherein L1, L2, L3, L4, R1, R2 and R3 are as defined for formula I and formula π; and # is the point of attachment to the rest of the molecule; R4a is selected from hydrogen, ci-ci〇 alkyl , CVCw haloalkyl, c2_Ci nonenyl, C2-C10 halo, C2-C10 fast radical, C2-Ci0 halo fast radical 'C3-Ci0 cycloalkyl, (: 3_(:10 halocycloalkyl, benzene a phenyl-CrC4 alkyl group, wherein the phenyl moiety in the last two mentioned groups may have 1, 2, 3, 4 or 5 substituents. R8' contains 1, 2 or 3 selected from a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring of a hetero atom of N, hydrazine and S, wherein the heterocyclic ring may have 1, 2 or 3 substituents R8, -C(=0) R5, -C(=S)R5, _SCC〇2R5, -CN, -P(=Q)R6R7 and Μ; R is selected from hydrogen, CVCm alkyl, CVCm haloalkyl, alkoxy, CVCw haloalkyl , Cl_Cl 〇 aminoalkyl, c3_Ci 〇 cycloalkyl, C3-C10_cycloalkyl, phenyl, phenyl-c^C4, phenyl, of which the last three are mentioned The phenyl moiety may have an anthracene, 2, 3, 147475.doc 201043139 substituent R8 containing 1, 2 or 3 heteroatoms selected from N, anthracene and S. a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring of a ring member, wherein the % can have 1, 2 or 3 substituent bases 8, &nr9rig; ', R6 and R7 are independently selected from each other Ci_Ci 〇 alkyl, c _Ci dentate alkyl, c10 alkenyl, c2-c10_ alkenyl, C 2 —Cio alkynyl, C 2 —Ci 〇 alkynyl, c 10 —alkyl, C 3 —Cl〇—alkyl, Ci—Ci decyloxy, Ci_Ci 〇 haloalkoxy, c "C4 alkoxy _Cl_Ci () alkyl, Ci_C4 alkoxy 4 ethoxy, CrCu sulphur, Ci, CiGli sulphur, c2_Ci. oxy, C10 Dilute sulfur group, c2_Ci, alkoxy group, c2_Ci, alkynylthio group, c3_Ci❹cycloalkoxy group, <^-(:1()cycloalkylthio group, phenyl group, phenyl-Ci_C4 alkyl 'phenoxy group, Phenylthio, phenyl-Ci-C4 alkoxy and NRnR12; each R8 is independently selected from the group consisting of halogen, nitro, CN, Ci_C4 alkyl, Ci_C4_alkyl, CVC4 alkoxy, c丨-c4 haloalkoxy And NR13R14; R9 is selected from hydrogen and (^(:8 alkyl·, R10 is selected from hydrogen, Ci_C8 alkyl, phenyl and phenyl-Ci_C4 alkyl; or R9 and RW together form a linear 匕 or ^ An alkyl bridge or group -CH2CH2OCH2CH2- or -CH2CH2NR15CH2CH2-;

Rn is selected from the group consisting of hydrogen and cvc8 alkyl; R12 is selected from the group consisting of hydrogen, Cl_c8 alkyl, phenyl and phenyl-Cl_c4 alkyl; or 1111 and 1112 together form a linear c4 or c5 alkyl bridge or group - CH2CH2OCH2CH2- or -CH2CH2NR15CH2CH2-;

Rl3 is independently selected from hydrogen and Ci-C8 alkyl at each occurrence; R14 is independently selected from hydrogen, Cl-C8 alkyl, phenyl, and styryl-C1-C4 alkyl at each occurrence; 147475 .doc 201043139 or ruler 13 and R14 together form a linear c4 or c5 alkylene bridge or group -ch2ch2och2ch2- or -ch2ch2nr15ch2ch2-; R15 is independently selected from hydrogen and (^-(:4 alkane) at each occurrence Q is 0 or S; Μ is a metal cation equivalent or an ammonium cation of the formula (NRaRbReRd)+, wherein Ra, Rb, Rc and Rd are independently selected from hydrogen, CrCl decyl, phenyl and phenyl fluorenyl Wherein the phenyl moiety of the last two mentioned groups may have 1 '2 or 3 substituents independently selected from the group consisting of halogen, cn, nitro, cvq alkyl, Cl_C4_alkyl, Cl_C4 alkane Oxyl, Cl_c4 haloalkoxy and NR13R14; η is 0, 1, 2 or 3; and bis (bond/dot bond combination) is a single bond or a double bond. The present invention also relates to a formula and a triazole Compounds and their agriculturally applicable salts,

L2 Η wherein L and L are independently selected from the group consisting of hydrogen, fluorine, bromine, moth, alkyl Cl_Cl oxime, Ci-C10 alkoxy and (^-〇10 haloalkoxy; 147475.doc 201043139 L and L3 is independently of each other selected from the group consisting of hydrogen, a functional element, c]-Ci 〇 alkyl, a Ci_Cu halogen group, a Ci-Cio alkoxy group, and a hydrazine (7) haloalkoxy group; the limiting conditions are L1, L2, L3 and L4. At least one of them is not hydrogen; R1 and R2 are independently of each other selected from the group consisting of hydrogen 'Cl_Ci 〇 alkyl, Ci_Ci 〇 烷基 匸, 匸 - - (: 10 alkoxy and (: _ _ (:! 〇 haloalkoxy) R3 is selected from the group consisting of hydrogen, (:, -(:!〇alkyl, (^-(^.haloalkyl, Ci_Ci〇alkoxy, and Cl-Ci〇_^oxy; R is selected from hydrogen, CVCw Alkyl, (^-0:1〇 haloalkyl, c2_Ci〇 alkenyl, C2-C1G i|alkenyl, c2-C1()alkynyl, c2-c1() _alkynyl, c3_Ci❹cycloalkyl, C3 -C10_cycloalkyl, phenyl, phenyl-Ci-C4 alkyl, wherein the phenyl moiety of the last two mentioned groups may have i, 2, 3, 4 or 5 substituents R8, and a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring containing i, 2 or 3 heteroatoms selected from the group consisting of N, hydrazine and s, wherein the heterocyclic ring may have 1, 2 or 3 substituents R8; or in the case where η is 〇, may also be selected from -C(=〇)R5 ' _C(=S)r5, _S(0)2R5, _p(=q)r6r7 Μ and a group of formula III,

Where L1, L2, L3, L'

RR & R is as defined for 147475.doc 201043139 of Formula I and Formula II; and # is the point of attachment to the rest of the molecule; R4a is selected from hydrogen, Ci-C^alkyl, Cl-C1() _ Burning base, c2_Ci. Dilute, C2-c1()haloenyl, C2-C1()alkynyl' c2-c1()-alkynyl, c3_Ci〇cycloalkyl, Cs-Cio halocycloalkyl, phenyl, phenyl-CVC4 An alkyl group, wherein the phenyl moiety of the last two mentioned groups may have 1, 2, 3, 4 or 5 substituents R8 containing i, 2 or 3 heteroatoms selected from N, fluorene and S a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring as a cyclist, wherein the heterocyclic ring may have 1, 2 or 3 substituents R8, -C(=0)R5, _s(〇 2r5 clothing • CN, -P(=Q)R6R7 and Μ; R is selected from hydrogen, C^-Cio alkyl, (^-Cw halogen, c ΓCi-C丨0 halogen oxy, Ci-Ci amidinoalkyl, c3-C10 ring-activated C^Cio halocycloalkyl, phenyl, phenyl-Cl_C: 4 alkyl, phenoxy, wherein the latter three groups are taken The phenyl moiety may have 1, 〇, 4 or 5 substituents R8, containing i, 2 or 3 heteroatoms selected from N, fluorene and 8 as a member of the ring oxime, 5 or 6 members saturated, partially unsaturated Or an aromatic heterocyclic ring wherein the heterocyclic ring may have 1, 2 or 3 substituents R8, and NR9R10; R6 and R7 are independently of each other selected from the group consisting of Cl_Cl0 alkyl, Ci_c, dentate alkyl, • C l. alkenyl, c2-Cl-dense, c2_ClQ alkynyl, C2_Ci, benzyl, cycloalkyl, C3_Cl, cycloalkyl, Ci_Ci, alkoxy, decyl alkoxy, C1-C4 alkoxy ke-Cl-Cl() alkyl, Cl_C4 alkoxyalkoxy Cl C1Q sulphur-based, (VCw thiol (thiol, C2-C1() ethoxylate, c2_" thiol, C2-Cl0 alkyne Base, c2_Clathio group, C3_CiQ ring group, h-Cio cycloalkylthio group, phenyl group, phenyl-Cl-C4 alkyl group, phenoxy group, 147475.doc 201043139 phenylthio group, phenyl-CVC4 alkoxy group And nr1!r12; each R8 is independently selected from the group consisting of halogen, nitro, CN, C-C4 alkyl, Ci_c4^ alkyl, CVC4 alkoxy, CVC4 haloalkoxy and NR13R14; R9 is selected from hydrogen and CVCs Alkyl; R10 is selected from CkCs alkyl, phenyl and phenyl-Cl_C4 alkyl; or R9 and R1G together form a straight chain (^ or ^alkyl bridge or hydrazine-CH2CH2OCH2CH2- or -CH2CH2NR15CH2CH2-; R11 Is selected from the group consisting of hydrogen and CVC8 alkyl; R12 is selected from the group consisting of Ci-C: 8-alkyl, phenyl and phenyl-Cl_c4 alkyl; or R11 and R12 together form a linear C4 or Cs alkylene bridge or group -CH2CH2OCH2CH2- or -CH2CH2NR15CH2CH2-; R13 is independently selected from the group consisting of hydrogen and hydrazine at each occurrence. An alkyl group; R14 is independently selected from the group consisting of Ci_C8 alkyl, phenyl and phenyl-CVC4 alkyl at each occurrence; or R13 and R14 together form a linear C4 or Cs alkylene bridge or group -ch2ch2och2ch2- or -ch2ch2nr15ch2ch2-; R is independently selected from hydrogen and alkyl at each occurrence; Q is ruthenium or S; ruthenium is a metal cation equivalent or an ammonium cation of formula (NRaRbReRd)+, wherein R, R, RC^Rd are each other The phenyl moiety independently selected from the group consisting of hydrogen, c--c10 alkyl, phenyl and phenylhydrazine, wherein the last two of the groups mentioned may have 1, 2 or 3 substituents independently selected from : halogen, cN, nitro Ci-C4 alkyl, Ci_c4_alkyl, C "C4 alkoxy, Ci_c4 haloalkoxy and NR13R14; 147475.doc 201043139 η is 0, ι, 2 or 3; and = ( The bond/point key combination) is a single bond or a double bond. The structures of the formulas I and II are thus represented by the following structures: ΙΑ, IIA, IB and IIB compounds: Ο

N

Η (ΙΑ) R4a I , Ν

I R43 I , Ν ^ γ^(〇)η^ Ν-Ν

丄2 Ή

L2 Η Ο (old) If R4 is a group of formula III in the compound oxime, it is a hydrazine group, #

(IHA) Η 147475.doc 201043139 In the IB, 'R4 is a group of formula 111, then it is a group of formula IIIB

This month also provides the use of the triterpenoids of formula 1 and formula 11 and/or their agriculturally suitable salts for the control of harmful fungi. The present invention further provides such trisodium compounds and/or agriculturally acceptable salts thereof comprising the formula I and/or formula 11 (and/or also formula IV, see below) And suitable for carriers. Suitable agriculturally acceptable carriers are described below. The compounds I and II may exist in the form of one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers, ligation isomers, and any isomers. Those skilled in the art will appreciate that a stereoisomer may be more active when it is enriched relative to other stereoisomers or when it is immediate, or may exhibit beneficial effects... well, it is known to those skilled in the art how to separate Enriching and/or selectively preparing the stereoisomers. The compounds of the invention may exist as a mixture of stereoisomers (e.g., racemates), as individual stereoisomers, or as optically active forms. In particular, the compounds of the formulae IA and IIA may exist in isomeric form with respect to the relative position of the hydrazine H group of the cyclopentane ring to its R3 L1 ^ group ^X^CH, which may be cis or L3 147475.doc - 12- 201043139; This Maoyue's cover is a cis isomer, a trans isomer and a mixture thereof. However, the preferred 4j spray isomer (formula IA-cis and formula ιΙΑ_cis compound): 〇

Compound I and hydrazine can be regarded as position/double bond isomers at least in the case where the groups R4/R4a are the same. In the case where R4 (and of course R4a) is hydrogen, the respective compounds I and hydrazine are tautomers.

Suitable salts for use in the industry are, in particular, the salts of their cations or the acid addition salts of their acids. The cations and anions thereof have no adverse effects on the combined fungicidal action, respectively. Thus, suitable cations are especially alkali metal (preferably sodium and potassium), alkaline earth metals (preferably calcium, magnesium and barium) and transition metal (preferably manganese, copper, zinc and iron) ions, and ammonium ions. The ammonium ion may have one to four Ci_C4 alkyl substituents and/or one phenyl or benzyl substituent, if desired, preferably diisopropylammonium, tetramethylammonium, tetrabutylammonium, trimethylbenzene The amide is further a scaly ion or a nickel ion, preferably a tris(C丨_C4 alkyl) fluorene and a cerium oxide ion, preferably a tri(Ci_C4 alkyl) cerium oxide. The anion of the acid addition salt is mainly chloride ion, bromide ion, fluoride ion, hydrogen sulfate, sulfate, dihydrogen phosphate, hydrogen phosphate, phosphate, nitrate, strontium carbonate, carbonate, hexafluoroantimony. Acid, hexafluorophosphate 147475.doc •13· 201043139 Root, benzoate, and anion of alkanoic acid, preferably formate, acetate, propionate and butyrate. It can be formed by reacting I or II with an acid of the corresponding anion (preferably hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid). In the definition of the variables given in the above formula, collective terms that generally represent the substituents in question are used. The term cn-cm indicates the number of possible carbon atoms in each case in the substituent or substituted moiety in question: halogen: fluorine, chlorine, bromine and iodine; alkyl and alkoxy, alkylcarbonyl, alkylthio a carbonyl group, an alkylamino group, a dialkylamino group, an alkylaminocarbonyl group, a dialkylaminocarbonyl group, an alkylthio group, a decyl group, and the like in the group: 1 to 2 (Cr C2 alkyl), 2 or 3 (C2-C3 alkyl), 1 to 4 ((^-04 alkyl), 1 to 6 (CVC6 alkyl), 1 to 8 (CVCs alkane) a saturated linear or branched hydrocarbon group of 1 to 1 (Cl-C1Q alkyl) carbon atom. The c2-c3 alkyl group is ethyl, n-propyl or isopropyl. The Ci-C2 alkyl group is hydrazine. Base or ethyl. c "C4 leucoyl is also propyl, isopropyl, butyl, 1-methylpropyl (second butyl), 2-methylpropyl (isobutyl) or 1, 1-dimercaptoethyl (t-butyl). Ci-C^alkyl is also additionally, for example, pentyl, 1-decylbutyl, 2-mercaptobutyl, 3-nonylbutyl, 2, 2-Dimercaptopropyl, 1-ethylpropyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, hexyl, benzyl Pentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-didecylbutyl, iota, 2-dimethylbutyl, I% dimethylbutyl Base, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 112_triterpene Propyl, 1,2,2-trimethylpropyl, ethyl-1-methylpropyl or ethyl-2-methylpropene 147475.doc 14- 201043139. c^-c:8 alkyl For example, heptyl 'octyl, 2-ethylhexyl and positional isomers thereof. C^-Cm alkyl is also additionally, for example, anthracenyl, fluorenyl, propylheptyl, 3-propylheptyl and their positions Haloalkyl: having 1 to 2 (CVC2 haloalkyl), 1 to 3 haloalkyl groups, 1 to 4 (CrCUi alkyl), 1 to 6 (Ci-Ce haloalkyl) ), 1 to 8 (Ci-C8_hospital), 1 to 10 (Ci-Ci. calcination) or 2 to 1 (c2·C10) alkyl or a straight chain or branched chain An alkyl group (as described above) wherein some or all of the hydrogen atoms of the groups may be replaced by a dentate atom 如上 as described above. Specifically, it is a Ci-C2 halogen group such as chloromethyl or bromine Methyl, dichloro Base, trimethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloro-methyl, difluoromethyl, 1-chloroethyl, 1-methyl 1-fluoroethyl, 2-fluoroethyl ' 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-gas-2-fluoroethyl, 2-chloro-2,2- Difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-dilactoethyl or five chaotic ethyl. Ci-C 〗 〖Huanxuan base is additionally for example 1,1,1 -Trifluoropropan-2-yl, 3,3,3-trifluoropropyl or heptafluoropropyl. The Cl-C4 halo q alkyl group is additionally, for example, 1-cyclobutyl, 2-chlorobutyl, 3-chlorobutyl or 4-chlorobutyl.

Ci-C1 () burned base: has 1 to 2 (Ci-C2 burned base), 1 to 4 (Cr * c4 hydroxyalkyl), 2 to 4 (C2-C4 hydroxyalkyl), 1 Up to 6 ((^-(^ hydroxy).), 2 to 6 (C2-C6 hydroxyalkyl), 1 to 8 (CVCs hydroxyalkyl), 2 to 8 (C2-C8 hydroxyalkyl) a linear or branched alkyl group (as described above) of 1 to 1 (cvCw hydroxyalkyl) or 2 to 10 (C2-Ci oxime) carbon atoms, wherein at least one hydrogen atom is via a hydroxyl group Substitution, such as 2-hydroxyethyl or 3-hydroxypropyl. Alkenyl and alkenyl groups in alkenyloxy, alkenylcarbonyl and the like: 147475.doc •15- 201043139 with 2 to 4 (C2 -C4 alkenyl), 2 to 6 (C2-C6 alkenyl), 2 to 8 (C2-C8-yl), 3 to 8 (C3-C8 alkenyl), 2 to 10 (C2-C10) Alkenyl) or 3 to 10 (C3_C1G alkenyl) carbon atoms and a monounsaturated linear or branched hydrocarbon group at the position of a double bond such as a CrC6 alkenyl group such as a vinyl group, a propylene group or a 2-propenyl group , 1-methylvinyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-mercapto-1-propenyl, 2-mercapto-1-propenyl, methacryl, 2-mercapto-2-propenyl, prepentenyl, 2-pentenyl, 3-pentenyl, 4-pentanyl, iota-methyl-hydrazine-butanyl, 2-methyl-^ Butenyl, 3-yl-1-butenyl, 1-methyl-2-butylenyl, 2-indenyl-2-butenyl, 3-yl-2-butenyl, !_methyl_3_ Butenyl, 2_fluorenyl_3-butenyl, 3-yl-3-butenyl, diindolyl-2-propenyl' fluorene, 2-dimethyl-1-enyl, 1,2- Dimercapto-2-propenyl, 丨_ethyl_丨-propenyl, "ethyl < alkenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5 alkenyl, 1-indolyl-^pentenyl, 2-methyl-N-pentenyl '3 methyl] 1-decyl-2-pentenyl 4-methyl-2-pentenyl 3- Methyl-3-pentyl 2-mercapto-4-pentyl 1,1-dimethyl-2-butenyl, -3-butenyl, ^-dimethyl-ibutenyl , li2_dimethyl-2-yl, 1,2-diindenyl-3-butenyl, indole dimethylbutenyl, indole-3-methyl-2-butenyl, U3_dimethyl _3_butenyl, 2,2-dimethyl, 2,3-methyl-butenyl, 2,3-diindenyl-2-butenyl, 2 3 methyl-3-butene Alkenyl, 3,3-dimethylbutenyl, 3,3·dimethyl alkenyl alkenyl Alkenyl 4-methyl-1-pentenyl 3-methyl-2-pentenyl 2-mercapto-3-pentenyl fluorenyl-4-pentenyl 4-methyl-4-pentene Base 2_mercapto-2 1-methyl-3 4_mercapto-3 3_methyl-4 methylmethyl hydrazine. propylene. pent. pent. pentane-pentyl. methylene--* a 1 —» .烯_一' field 147475.doc -16· 201043139 base, 1-ethyl-1-butenyl, 1-ethyl-2-butanthyl, 1-ethylbutyl group, 2-ethyl 1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-2-butenyl, 1,1,2-dimethyl-2-propenyl, 1-ethyl_ι_ a methacryl group, an ethyl-2-methyl-1-propenyl group, a hydrazine-ethyl 2-methyl-2-propenyl group and the like; a halogenated group and an oxyalkylene group a dentate moiety in a carbonyl group and the like. It has 2 to 4 (C2-C4 functional alkenyl) groups, 2 to 6 (C2-C6 halogenated groups), 2 to 8 (C2-C8 _ Alkenyl) or 2 to 10 (C2-C1()-alkenyl) carbon atoms and an unsaturated linear or branched hydrocarbon group at the position of a double bond at any position (as described above) wherein some of these groups Or all of the hydrogen atoms may be replaced by a halogen atom (especially fluorine, chlorine and bromine) as described above, for example a vinyl chloride group, a chloroallyl group, and the like; an alkynyl moiety in a fast and alkynyloxy group, an alkynylcarbonyl group, and the like: having 2 to 4 (C2-C4 alkynyl groups), 2 to 6 (C2-C6 alkynyl), 2 to 8 (C2-Cg block), 3 to 8 (C3-Cs alkynyl), 2 to 10 (C2-CW alkynyl) or 3 to 1 0 a (C3_C1()alkynyl) carbon atom and one or two straight or branched chain hydrocarbon groups at any position, such as a C2-C6 alkynyl group, such as ethynyl, 1-propynyl, 2-propyne Base, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-cyano, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentyl Alkynyl, 1-mercapto-2-butynyl, 1-hydrazino-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl Base 2 -propynyl, 1-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1 -Methyl-2-pentynyl, 1_fluorenyl-3-cycloynyl, 1-indenyl- 4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4- Pentynyl, 3-methyl-1-pentynyl, 3-147475.doc •17- 201043139 decyl-4-pentynyl, 4-methyl-1-pentynyl 4-methyl-2-pentynyl, iota, ΐ-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butene Alkynyl, 2,2-dimercapto-3-butynyl, 3,3-dimercapto-1-butynyl, ethyl-2-butanyl, 1-ethyl-3-butyne , 2-ethyl-3-butynyl, 1-ethyl-1-methyl-2-propynyl and the like; haloalkynyl and ethynyloxy, i-alkynylcarbonyl and the like a haloalkyne moiety in the group: 2 to 4 (C2-C4-alkynyl), 2 to 6 (C2-C6 haloalkynyl), 2 to 8 (C2-C8-alkynyl) or 2 Up to 10 (C2-C1G-alkynyl) carbon atoms and one or two unsaturated linear or branched hydrocarbon groups (as described above) at any position, wherein some or all of these groups are hydrogen The atom may be replaced by a halogen atom (especially fluorine, gas, and bromine) as described above; a cyclodyl moiety in the hexyl group and the sulphonyloxy group, the cycloalkyl group, and the like: having 3 to 6 Monocyclic saturated hydrocarbon groups (CVC6 cycloalkyl), 3 to 8 (C3_C8 cycloalkyl) or 3 to 10 (C3-C1G cycloalkyl) carbocyclic members, such as cyclopropyl, cyclobutyl, ring Pentyl, cyclohexyl, ring a cyclyl group, a cyclooctyl group, a cycloalkyl group and a cycloalkyl group; a halocycloalkyl moiety in a cycloalkyl group and an i cycloalkoxy group, a ring cycloalkylcarbonyl group, and the like: having 3 to 6 (CrC6) Halocycloalkyl), 3 to 8 (C3_CS halocycloalkyl) or 3 to fluorene (C3_c1 fluorenylcycloalkyl) carbocyclic ring members of a monocyclic saturated hydrocarbon group (as described above), some or all of which are hydrogen The atom may be replaced by a pixel atom as described above (especially fluorine, chlorine and bromine); an alkoxy group. The Ci_C2 alkoxy group is a methoxy group or an ethoxy group. Further, the Ci-C4 alkoxy group is, for example, n-propoxy 'indole-methylethoxy (isopropoxy), butoxy, i-methylpropoxy (second butoxy)' 2_ Base 147475.doc 201043139 Propoxy (isobutoxy) or u-dimethylethoxy (t-butoxy p Ci_C6 alkoxy is additionally, for example, pentyloxy, i-methylbutoxy, 2-methylbutoxy, %methylbutoxy, dimethylpropoxy, hydrazine, 2-dimethylpropoxy, 2,2-dimethylpropoxy' 1-ethylpropoxy , hexyloxy, 1-decylpentyloxy, 2-fylpentyloxy, 3-methylpentyloxy, 4-methylpentyloxy, dimethylbutoxy, 1,2-di Methylbutoxy, hydrazine, 3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, ι,ι,2-trimethylpropoxydimercaptopropoxy, 1-ethyl-i-methylpropoxy or hydrazine Ethyl-2-nonylpropoxy. C^-Cs alkoxy is additionally, for example, heptyloxy, octyloxy, ethyl-2-hexyloxy and positional isomers thereof. Cl_Ci decyloxy is additionally For example, decyloxy, decyloxy and their positions The C2-C1G alkoxy group is, for example, a Cl_C10 alkoxy group, other than a decyloxy group. A haloalkoxy group: partially or completely substituted by fluorine, chlorine, bromine and/or iodine, preferably substituted by fluorine as described above. The alkoxy group haloalkoxy is, for example, 〇ch2f, ochf2, OCF3, OCH2 (M, OCHCl2, occi3, chlorofluoromethoxy, difluorofluoromethoxy, chlorodifluoromethoxy, 2-fluoroethyl) Oxyl, 2-lactylethoxy, 2-ethoxyethoxy, moth ethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-gas-2- Fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichloroethoxy or hydrazine C2F5. The oxy group is additionally, for example, 2-fluoropropoxy, 3-fluoropropoxy, 2,2-difluoropropoxy, 2,3-difluoropropoxy, 2-propoxy, 3-propane. Oxyl, 2,3-dichloropropoxy, 2-bromopropoxy, 3-bromopropoxy, 3,3,3-trifluoropropoxy, 3,3,3-trichloropropoxy , OCH2-C2F5, 〇CF2-C2F5, 147475.doc -19- 201043139 1- (CH2F)-2-murine ethoxy 2 . , . . , , ( 2C1)'2'^^^^ ' l-( CH2Br)- 2-Bromoethyl lactyl 4_murineoxy, 4-gas butyl 1 wind 1 Butyl, 4-bromobutoxy or 9 The milk-based Cl_C6 haloalkoxy group &amp; also 丨lr animal ..., ... ride another for example 5 · fluoropentyloxy, 5-air pentylene, 5-> skox oxy, 5 _ 士 and children峨戍 峨戍 峨戍, 十-Fluoropentyloxy, 6-1 hexyl, 6-gas hexane, 6 bromohexidine, hexyloxy, 6, hexyloxy or decyl Oxygen. Alkenyloxy: via an oxygen atom χ ^ ▲ an alkenyl group as described above, for example, C2-C 1 oxime oxyl group such as 1 _ 7 knee vinylidene, 1-propenyloxy, 2-propenyloxy , I-methylethyleneoxy, 1-butane nitrogen, butenyl, 2-butenyloxy, 3-butene oxide = methyl propyleneoxy, 2-methyl + propylene oxide Base, ι_methyl_2_p-milyl, 2-methyl-2-(4-)oxy, quinolyloxy, 2_戍 sulphur, 3 戍 乳, 4, penteneoxy, 1 -Methyl-1-butenyloxy, 2_曱=small butenyloxy, "yl·1·butanoxy, 1-methyl-2-butenyloxy: 2 dimethyl-2-indene Dilute oxy, 3-methyl-butenyloxy, benzyl oximeoxy 2 methyl _3_butoxy, 3 methyl _3 · butyl, I, dimethyl methacrylate Oxyl, with: methyl propylene oxy, decyl dimethyl | propyl ethoxy, 1-ethyl-1- propyloxy, 1-ethyl-2-propenyloxy, hexyl, oxy , 2-hexenyloxy, 3-hexamethoxyoxy, hexenyloxy, 5-hexeneporyl, 1-methylpentaloxy, 2-methyl"penteneoxy, 3 ^基_1_pentenyloxy, 4·methyl-1·pentyloxy, 1-methyl 2-pentenyloxy, 2_:yl-2-pentyloxy, 3rn-pentenyloxy, 4·methyl-2-penteneoxycoxide, methyl-3-pentenyloxy, 2 _Methyl_3_pentamethoxy, 3-methylpentenyloxy, 4-methyl-3-pentenyloxy, 1-methyl-4-pentenyloxy, 2-methyl-4 -Valentyloxy, 3-methyl-4 pentyloxy, 4-methylpentene oxide W475.doc -20- 201043139 ❹

,,-di-f-yl-2-butenyloxy, u&lt;f-based _3-butenoxy, 1,2-monodecylbutenyloxy, dimethyl-1-butyloxy, I. Methyl-3-butenyloxy, decyldimethylbutanyloxy, dimethyl-2-butenyloxy, 1,3-dimethyl-3-indoxy, 2,2_ Dimethyl-3-butanyloxy, 2,3-dimethylbutenyloxy, 2,3-diindolyl-2-butenyloxy, 2,3-dimethyl-3-indene Dilute oxy, 3,3-dimethyl-dibutyloxy, 3,3-dimethylbutanyloxy, ethylidene-butenyloxy, 1·ethylbutoxyoxyl, 1-B Alkyl-3-butadienyloxy, 2-ethylbutylbutenyloxy, 2-ethyl-1-butenyloxy, 2-ethyl-3-butenoxy, u, 2jf-based 2-propene Oxyl, 1-ethyl-1-methyl-2-propenyloxy, i•ethyl-2-methylpropanoxyoxyl and 1-ethyl-2-methyl-2-propenyloxyl A similar group; haloalkenyloxy: an alkenyloxy group as defined above, partially or completely substituted with fluorine, chlorine, bromine and/or iodine, preferably substituted by fluorine. Alkynyloxy: alkynyl group as described above attached via an oxygen atom, for example c2_c10 alkynyloxy, such as 2-propynyloxy, 2-butynyloxy, 3-butynyloxy, 1-methyl-2 -propynyloxy, 2-pentopentoxy, %pentynyloxy, 4-pentynyloxy, 1-methyl-2-butynyloxy, benzyl-3-butynyloxy, 2-methyl -&gt; butynyloxy, 1-ethyl-2-propynyloxy, 2-hexynyloxy, %hexynyloxy, 4·hexynyloxy, 5-hexynyloxy, 1-methyl Alk-2-pentynyloxy, benzyl-3-pentynyloxy and the like; a haloalkoxy group: partially or completely substituted by fluorine, gas, bromine and/or iodine, preferably by fluorine The alkynyloxy group. Cycloalkoxy. A ring alkoxy group as described above attached via an oxygen atom, such as a C3-C1Gi succinyl or a C3_CS ring alkoxy group, such as cyclopropoxy, cyclopentane 147475.doc -21 - 201043139 Oxygen a group, a cyclohexyloxy group, a cycloheptyloxy group, a cyclooctyloxy group, a cyclodecyloxy group, a cyclodecyloxy group, and the like; a cycloalkenyloxy group; a cyclooxyl group as described above attached via an oxygen atom For example, C3_C1?cycloalkenyloxy, C3_Cscycloalkenyloxy, or preferably c5_C6cycloalkenyloxy, such as cyclopent-1-enyloxy, cyclopent-2-enyloxy, cyclohexyl-1-ene Oxyl and cyclohex-2-enyloxy; alkoxyalkyl: having 1 to 10, 1 to 8, 1 to 6 or 1 to 4, especially 1 to 3, carbon atoms as defined above An alkyl group in which one hydrogen atom is replaced by an alkoxy group having from 1 to 8, from 1 to 6, or especially from 4 to 4 carbon atoms, such as methoxymethyl, 2-methoxyethyl, ethoxy Indenyl, 3-methoxypropyl, 3-ethoxypropyl and the like. Alkoxy alkoxy: an alkoxy group as defined above having 1 to 1 、, 1 to 8, 丨 to 6 or 至4, especially 1 to 3, carbon atoms, wherein one hydrogen atom has Substitution of 1 to 8, 1 to 6 or especially alkoxy groups up to 4 carbon atoms, for example 2-methoxyethoxy, 2-ethoxyethoxy, 3-methoxypropoxy , 3-ethoxypropoxy and the like. Alkylcarbonyl: a group of the formula R-CO- wherein R is an alkyl group as defined above, e.g., cvc. An alkyl group, a cvc8 building group, a Cl_C6 alkyl group, a Ci_c^ group, a Ci-C2 alkyl group or a Cs-C4 alkyl group. Examples are ethyl acetyl, propyl thiol and the like. Examples of the CrC4 alkylcarbonyl group are a propylcarbonyl group, an isopropylcarbonyl group, a n-butylcarbonyl group, a second butylcarbonyl group, an isobutylcarbonyl group and a tert-butylcarbonyl group. Alkoxycarbonyl: a group of the formula Rc〇- wherein R is an alkoxy group as defined above. Example WCVCio alkoxy, CVC8 alkoxy, Cl_coxy, Cl_147475.doc -22-201043139 G alkoxy Or an example of alkoxyl^Cl_C4 alkoxyalkyl group is methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxyx, second butoxycarbonyl, isobutoxycarbonyl and Third butoxycarbonyl. Alkylsulfonyl: a group of the formula R-S(0)2- wherein R is a cyclyl group as defined above, for example, a CrCw alkyl group, a Cl-C8 alkyl group, a Ci_c6 alkyl group, a Ci_Cj group or a CrC: 2 alkyl group. Examples of Cl_(:4 alkoxysulfonyl are methanesulfonyl, ethylsulfonyl, propanesulfonyl, isopropylsulfonyl, n-butylsulfonyl, second butasulfonyl, isobutylsulfonate Sulfhydryl group and tert-butylsulfonyl group. Sulfur-based group: a thiol group as defined above via a sulfur atom. Tetraalkylthio group: an alkyl group as defined above via a sulfur atom. Alkylthio group: linked via a sulfur atom The aryl group as defined above: i-enylthio: a decyl group as defined above attached via a sulfur atom. alkynylthio: an alkynyl group as defined above attached via a sulfur atom. A defined alkynyl group. A cycloalkylthio group: a cycloalkyl group as defined above attached via a sulfur atom. A phenyl-CrC4 alkyl group: a Ci_c4 alkyl group (as defined above) in which a hydrogen atom is replaced by a phenyl group, such as a benzyl group, Phenylethyl and the like. Phenyl-Ci-C: 4 alkoxy: a hydrogen atom substituted by a phenyl alkoxy group (as defined above), such as phenylhydrinyloxy, phenethyloxy and Similar group. 3, 4, 5, 6, 7 or 8 members, 9 members or 1 employee saturated, partially unsaturated or aromatic a ring containing 1, 2, 3 or 4 heteroatoms from a group consisting of oxygen, nitrogen (in the form of N or NR) and sulfur (in the form of s, 8 or § 〇 2) and optionally 1 Or 2 groups selected from c(=〇) and c(=s) as a ring 147475.doc -23- 201043139 Members: - two, four, five or six members of saturated or partially unsaturated heterocyclic rings ( Also referred to hereinafter as heterocyclyl), it contains one, two, three or four impurities from a group consisting of oxygen, nitrogen (in the form of N or NR) and sulfur (in the form of S, SO or S〇2). One or two groups selected from C(=0) and C(=S) as a ring member, such as a monocyclic saturated or partially unsaturated heterocyclic ring, which is contained in addition to the carbon ring member. One to two gas atoms and/or one oxygen or sulfur atom or one or two oxygen and/or sulfur atoms and optionally one or two groups selected from the group consisting of c(=〇) and C(=S), For example, 2-oxiranyl, 2-thietyl, aziridine or 2-aziridine, 1-azetidinyl, 2-azetidinyl or 3-aza Cyclobutyl, 2-tetrahydrofuranyl, 3·tetrahydrofuranyl, 3-tetrahydrofuran-2-one, 4-tetrahydrofuran- 2-keto, 5-tetrahydrofuran-2-keto, 2-tetrahydrofuran-3-yl, 4-tetrahydrofuran-3.one, 5-tetrahydrofuran-3-yl, 2-tetrahydrothiophenyl, 3-tetra Hydrothienyl, 3_tetrahydrothiophene-2 keto, 4_tetrahydrothiophen-2-one, 5-tetrahydrothiophene-2-keto, 2_tetrahydrothiophene-3-olone, 4-four Hydrothiophen-3-one, 5-tetrachlorothiophene-3-ylketone, 2-pyrrolidinyl, 3-pyrrolidinyl, pyrrolidine-2-one, 3-pyrrolidine-2-one, 4_ Pyrrolidin-2-one, 5-pyrrolidin-2-yl, bupyridyl-3-yl-keto, 2-pyrrolidin-3-one, 4-pyrrolidin-3-ylyl, 5-pyrrolidine _3_keto, bupyrolidine-2,5-dione, 3-pyrrolidine, 2,5-dione, 3-isoxazolidine, 4-isoxazolidinyl, 5-iso Oxazolidine, 3-isothiazole, 4-isothiazolidinyl, 5-isothiazolidinyl, 3-pyrazolidinyl, 'pyrazolidine, 5-pyrazolidyl, 2-oxazolidine , 4-oxazolidinyl, 5-oxazolidinyl, 2-thiazolyl, 4-thiazolidinyl, 5-thiazolidinyl, 2-imidazolidinyl, [imidazole 147475.doc •24· 201043139 pyridine 1,2,4-oxadiazolidine-3-yl, 1,2,4-oxadiazolidine-5-yl, 1,2,4- Thiazolidine-3-yl, 1,2,4-thiadiazolidin-5-yl, 1,2,4-triwax-3-yl, 1,3,4-oxadiazolidine-2 -yl, 1,3,4-thiadiazolidin-2-yl, 1,3,4-tri. Sitting bite 2-yl, 2,3-dichloro-butan-2-yl, 2,3-dinitro-indolyl-3,yl, 2,4_dioxifufan-2-yl, 2,4 -diaza-α-furan-3-yl, 2,3-diaza π-phenant-2-yl, 2,3-dioxanthin-3-yl, 2,4-diazin-2-yl , 2,4-dinitro-α-cetin-3-yl, 2-α-specific ratio #木-2-yl, 2 - ntb 咐- 3 -yl, 3 - ^ 比略·吓与 > 2- base , 3 - °, morpholin-3-yl, 2-isoxazolin-3-yl, 3-isoxazolin-3-yl, 4-isoxazolin-3-yl, 2-isoxazole Borano-4-yl, 3-isoxazolin-4-yl, 4-isoxazolin-4-yl, 2-isoxazolin-5-yl, 3-isoxazolin-5-yl, 4-isoxazolin-5-yl, 2-isothiazolin-3-yl, 3-isothiazolin-3-yl, 4-isothiazolin-3-yl, 2-isothiazolin-4-yl , 3-isothiazolin-4-yl, 4-isothiazolin-4-yl, 2-isothiazolin-5-yl, 3-isothiazolin-5-yl, 4-isothiaphetyl-5 -yl, 2,3-dihydrogen. ratio. Sitting on a 1-yl, 2,3-dihydrogen. The ratio of 2-yl, 2,3-dihydrogen is lower than that of -3-yl, 2,3-dihydroindole-4-yl, 2,3-dihydrogen. Take 5-amino, 3,4-dihydroanthracene. Sitting on a -1-base, 3,4-dihydrogen ratio. Take -3- group, 3,4-dione. Specific ratio of 4-butyl to 3,4-dihydrogen. Sitting on -5-yl, 4,5-dihydrogen ratio to -1-yl, 4,5-dihydrogen ratio °-3-yl, 4,5-dihydrogen ratio quaternary-4-yl, 4 ,5-dihydrogen ratio thio-5-yl, 2,3-dihydrooxazol-2-yl, 2,3-dihydrooxazol-3-yl, 2,3-dihydrooxazole-4- Base, 2,3-dihydro oxime-5-yl, 3,4-dihydro &quot; evil. Sit-2-yl, 3,4-dihydrogen. 3-O-, 3,4-dihydrooxazol-4-yl, 3,4-dihydrooxazol-5-yl, 3,4-dihydrooxo-y-yl, 3,4- Diazo π oxasin-3-yl, 3,4-dichloro. Ethylene-4-yl, 2-Benbite, 3-N-Bottom, 4-bite, 1,3-dioxax-5-yl, 2-tetrahydro. Decanyl, 4-tetrahydrofuranyl, 2-tetrahydrothiophenyl, 3-hexahydropyridazinyl, 4-hexa 147475.doc -25- 201043139 hydropyridazinyl, 2-hexahydropyridinyl, 4_hexahydropyrimidinyl, 5-hexahydropyrimidinyl, 2-brenyl, U,5-hexanitrogen. a group of saturated or partially unsaturated heterocyclic rings containing -, two, three or four from a group consisting of oxygen, nitrogen and sulfur A hetero atom as a ring member: a compound having 7 % of a ring of monocyclic and bicyclic heterocycles containing, in addition to a carbocyclic ring member, - to three nitrogen atoms and/or an oxygen or sulfur atom or one or two Oxygen and/or sulfur atoms, for example, J, such as the four-wind SL group and hexahydro-hydrogen group, such as (10) tetrahydro-nitrogen, _3, _4, _5, each or _7_ group '3, 4, 5 , 6-tetrahydro[2H] m...3-, _4_, _5_, winter or _7_ group, 2,3,4,7, hydrogen_azepine-1-, -2 - -3_, _4·, _5_, _6_ or 7-base, 2,3,6,7, tetrahydrofl戦, small, _2_, _3_, m = kiln 'hexahydroazepine small, _2 ·, ... base; tetrahydrooxo group and six Duct base, such as 2,3,4,5-tetrahydro-oxo-2-, -3, _4_, _5_, winter or '7_ base, 2,3,4,7·tetrahydroanthracene] 2·,-3·,·4·,-5-,_6_ or _7·yl, 2,3,6,7, hydrogen_oxo-2...3·,-4_,-5-,6 or -7-based, hexahydroazepine +, _6-I... group, tetrahydrogen hydrogen... or nitrogen: ...hexahydro _ Μ ·Nitrogen-based, tetrahydrogen and a TM-based, four winds and hexachloro-I3, 虱-1,4-oxo-oxime, tetrahydro- and hexahydro-oxo-h, oxy-quot; Five members d, ,-- ipidyl, and corresponding subunits; two, three or four from: heterocyclic oxime aromatic groups, which contain a group of carbon-linked and containing - to sulfur An atom, such as a sulfur or an oxygen atom, acts as a ring-::::- or two nitrogen atoms and a 5-membered heteroaryl group, such as 2_coughyl, 夂147475.doc -26- 201043139 furanyl , 2-thienyl, 3-thiophenyl, 2-pyrrolyl, 3-pyrrolyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, 3-isothiazolyl, 4- Isothiazolyl, 5-isothiazolyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2-oxanyl, 4-oxazolyl, 5-oxazolyl, 2-thiazolyl , 4-thiazolyl, 5-°-sodium-based, 2-meridino, 4-ρ米η, 1,2,4-° dioxin-3-yl, 1,2,4- °恶二° sit-5_ base, 1,2,4-oxadiazol-3-yl, 1,2,4- oxadiazole-5-yl, 1,2,4-dioxin-3-yl, 1,3,4-° dioxa-2-yl, 1,3,4-β-dithio-2-yl and 1,3,4-disindol-2-yl a 5-membered heteroaryl group which is bonded via a nitrogen and contains one to three nitrogen atoms as a ring member, such as pyrrole-fluorenyl, pyrazole-indenyl, imidazolium-hydrazino, 1,2,3-triazole-b And 124-triazole-fluorenyl; 6-membered heteroaryl containing one, two or three gas atoms as ring members, such as pyridin-2-yl, pyridine-3-yl, D-bit-4-yl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl, triazine-2-yl and anthracene, 2,4triazin-3-yl (: 2_〇5 alkylene: a divalent branched chain having 2 to 5 carbon atoms or preferably an untwisted branching bond such as CH2CH2, (3⁄43⁄4⁄4, (:, CH2CH(CH3), CH2CH2CH2CH2, ch2ch2ch2ch2ch2). The group -SM is more specifically the group S-M+, wherein M+ is as defined above. I is a positive equivalent or a (four) material. The metal cation (tetra) is more specifically 1/a Ma+, where s ^ μ 〃, the valence of the genus A. genus and is generally 丨, 2 or 3. In the following, the fenfen substituents m, R4, R4a, R, m, R9, R1°, R, 1, Rl2, 〜14, 〜, 〜, L4, Ra Rb, Re, Rd and The index is effective from the statement of its use, and especially in the mouthfuls and better characteristics of the mouth, especially in the possible combination of each of the possible combinations of the pair of nl R2, p3, liu 147475.doc -27- 201043139. Preferred are compounds IA and IIA. Among the compounds IB and IIB, the following isomers IB-1 and IIB-2, ^Ny^S(0)nR4 n~n are preferred.

Therefore, it is preferably the following isomer of the group ,,

(IMB-1)

According to the preferred embodiment of the present invention, l2 and independently of each other, chlorine, spectroscopy, Cl-c4 appearance, Cl, Ki, and (C4i alkoxy) are more preferably selected from hydrogen, teeth. a C1_C3 alkyl group, (4) a toothed earth Cl C3 ** oxy group and a Cl~C3 functional alkoxy group, specifically selected from the group consisting of hydrogen, , fluorenyl 'fluoromethyl, di-methyl methyl, tri-methyl, Methoxy, oxyfluoride-fluoroethoxy, 2,2,2·trifluoroethoxy, 1,1,2,2.tetrafluoroethyl and pentafluoroethoxy' and especially selected from hydrogen and In particular, L2 and both are hydrogen' or both are hydrogen and the other is gas. 147475.doc -28- 201043139 According to a preferred embodiment of the invention, L1 and L4 are selected independently of each other. Self-gas fluorine odor, Ct-C4 alkyl group, C1-C4 halogen group, Ci-C^ alkoxy group and Cl C4 haloalkoxy group, more preferably selected from hydrogen, fluorine, bromine, CVC3 alkyl group, (^ _C3 calcinyl group, C1_C3 alkoxy group and (^-(:3 haloalkoxy group, specifically selected from the group consisting of hydrazine, fluorine, bromine, fluorenyl, fluoromethyl, difluoromethyl, trifluoromethyl, Monofluoroethyl, 2-tetraqiethyl, penta-ethyl, decyloxy, fluoromethoxy, difluoromethoxy, trifluoromethyl a 2,2,2-trifluoroethoxy group, a tetrafluoroethoxy group, and a pentafluoroethoxy group, and is particularly selected from the group consisting of fluorine, bromine, methyl, trifluoromethyl and trifluoromethoxy, and Selected from hydrogen, fluorine, and CF 3. According to another preferred embodiment of the present invention, one or both of L1, L2, L3 &amp; L4 are not hydrogen, and in particular, at least - not chlorine in LjL4. In a preferred embodiment of the present invention, one of L1 and L4 is not hydrogen and the other is chlorine. According to another preferred embodiment of the present invention, at least one of L2 and L3 is hydrogen. According to the present invention A preferred embodiment is preferably chlorine and the other is hydrogen; or both L2 and L3 are 氲_, and according to a particularly preferred embodiment of the invention, L丨 and 1/1 are not hydrogen. And especially for the formula or cf3) 'and all other substituents L (ie, l2, LiLi or widely hydrogen, or one of the additions are not hydrogen (and especially gas or (d)), 3 are not hydrogen (and especially Chlorine), and all other substituents F | ie % or L and L2 or 0 are hydrogen (especially Ll is not hydrogen (and especially gas or CF3), L is chlorine, and L3 &amp; L4 is hydrogen L and L Particularly preferred combinations are compiled in the table below: 14 7475.doc -29· 201043139 No. L1 L2 L3 L4 1 FHHH 2 Br HHH 3 ch3 HHH 4 ch2ch3 HHH 5 CH(CH3)2 HHH 6 cf3 HHH 7 ch2cf3 HHH 8 CF2CHF2 HHH 9 OCF3 HHH 10 OCH2CF3 HHH 11 OCH3 HHH 12 OCH2CH3 HHH 13 F Cl HH 14 FH Cl H 15 ch3 H Cl H 16 ch2ch3 H Cl H 17 CH(CH3)2 H Cl H 18 cf3 H Cl H 19 ch2cf3 H Cl H 20 CF2CHF2 H Cl H 21 OCF3 H Cl H 22 OCH2CF3 H Cl H 23 och3 H Cl H 24 OCH2CH3 H Cl H 25 ch3 Cl HH 26 CH2CH3 Cl HH 27 CH(CH3)2 Cl HH 28 cf3 Cl HH 29 ch2cf3 Cl HH 30 CF2CHF2 Cl HH 31 OCF3 Cl HH 32 OCH2CF3 Cl HH 33 Och3 Cl HH 34 OCH2CH3 Cl HH In the above combination, a combination is preferred in which L2, L3 and L4 are hydrogen, or wherein L2 is Cl and L3 and L4 are hydrogen. Particularly preferred are combinations of Nos. 1, 6, and 13. Preferably, R1 and R2 are independently of each other selected from the group consisting of hydrogen, (VC4 alkyl, (VC2 147475.doc -30-201043139 decyl, Cl-C4 alkoxy, and Cl_C2i). More preferably, R2 is independent of each other. It is selected from the group consisting of chlorine, methyl, ethyl and trimethyl. Even more preferably, it is independently selected from hydrogen and methyl. It is specifically a methyl group. And preferably, R3 is selected from hydrazine. , CA hospital base, Cl.c2i alkyl group, Cl_c alkane base and ^2 morphine oxy group. More preferably, it is selected from the group consisting of chlorine, methyl sulfonium ethyl ester and trimethyl sulfhydryl group. Even more preferably, R3 is selected from the group consisting of chlorine and methyl, and R3 is hydrogen. R5 in the group R5 and -S(0)2R5 are preferably selected from the group consisting of Cl-C group, alkyl group, and Cl-C4 oxygen. a base, a Ci_c2_ alkoxy group, a phenyl group and an NRV〇, more preferably selected from the group consisting of Ci_C4, Ke_c^, oxy, CVC2, and NR9R1, and even more preferably selected from the group consisting of V. In the group -C(=0)R5, R5 is specifically defined as a radical: a radical, more specifically an isopropyl group, an isobutyl group or a tert-butyl group, and in the group, R5 is specifically referred to as a fluorenyl group. Preferably, R9 is hydrogen and is derived from hydrogen, q-C4 alkyl and phenyl, preferably selected From hydrogen and C1_C4 alkyl. R is preferably selected from the group consisting of hydrogen, CVC4 alkyl, _c(=〇)R5, _s(〇)2R5, Μ, and the group of formula III, R5, having one or more of the above general meanings. One of the above preferred meanings, and one of the above-mentioned general meanings - or one of the preferred meanings given below in particular. R4 is more preferably selected from the group consisting of hydrogen, Cl-C4 alkyl, C3_C4 alkylcarbonyl, Ci_C4 alkoxycarbonyl, -CPCONODCVC4 alkyl, Cl_C4 alkylsulfonyl, CN and a group of formula III and even more preferably selected from hydrogen and Ci_C4 alkyl. In particular, R4 is selected from the group consisting of hydrogen, CN and methyl. R4 is especially hydrogen. 147475.doc • 31- 201043139 Μ is preferably selected from the group consisting of an alkali metal cation, an alkaline earth metal cation equivalent, a cation equivalent of Cu, Zn, Fe or Ni, or a cation of the formula (NRaRbRCRd)+. Wherein one of Ra, Rb, and Rd is hydrogen and two of Ra, Rb, Rc, and R are independently selected from the group of q-Cm. The VI is preferably selected from the group consisting of Li, Na, K+, and WMg2. a cation equivalent of Cu, Zn, Fe or Ni, and an ammonium cation of the formula (NRaRbRcRd)+, wherein one of Ra, Rb, RC&amp; Rd is hydrogen and Ra, Rb, ruler, and Rd The three are independently selected from each other by CVC. The alkyl group is even more preferably selected from the group consisting of Na+, K+, 1/2Mg2+, 1/2Cu2+, !/2Zn2+, WFeh, ΖΝβ, triethylammonium and trimethylammonium. In the group, the variable preferably has the same meaning as in the rest of the molecule 1. Therefore, the above statements regarding the preferred meaning of the group also apply to this section. R4a is preferably selected from the group consisting of hydrogen, Cl_Cl0 alkyl, Cl_C4 haloalkyl 'phenyl, phenyl-C]-C4 alkyl and _C(=〇)R5, wherein r5 has one of the general meanings given above or One of the preferred meanings given above in specific terms. R4a is more preferably selected from the group consisting of hydrogen, CVC4 alkyl, Cl_c4 haloalkyl, phenyl, benzoinyl, ·c(=〇)r5 and -s(o)2r5, and R5 in the oxime has the general meaning given above. Or one of the preferred meanings given above, and more preferably selected from the group consisting of hydrogen, Cl_C4 alkyl, and, 2R5', wherein r5 has one of the general meanings given above or specifically stated above Give one of the better meanings. In particular, R is hydrogen, Ci-C:4 alkyl or CrC4 haloalkyl, more specifically hydrogen or fluorenyl-decyl&apos; and especially hydrogen. If η is 1, the oxygen atom is preferably bonded to the sulfur atom via a double bond, and the group -S(〇)n-R4 thus produces a group _s (which is r4. 147475.doc •32- 201043139 〇_r4. For 3 ' then the group -S(0)n-R4 is a group -S(=〇)2- n is preferably 〇. In compounds I and II, servant a private τ ± ΙΑ is preferred. The s material 1 is preferred. In the compound I, the compound specific compound IA is as follows: Ο Ο 5-(2-fluoro-benzylmethylcyclopentanol; silk '(1) to]三嗤]·基曱基)-2,2-二5-(2_二气methyl_笨甲甲,1 苴,Λ Τ丞)·1^5-巯基-[1,2,4]三Oxazol-1-ylethane)_2,2-tetramethylcyclopentanol; and 5-(2-fluoro-3-chloro-benzyl 1 2 )-(5' fluorenyl-[1,2,4] Triazol-1-ylmethyl)-!-dimethylcyclopentanol. Preferred compounds I and 11 are the compounds of the formulae 1.1 to 1.16 and II.1 to Π.8, wherein the variables have the general meaning ^ ^ _ &amp; One of the preferred meanings. Preferred compounds are exemplified by the individual compounds compiled in Tables 1 to 688 below. In addition, the meanings mentioned in the table below for individual variables are in themselves a particularly preferred embodiment of the substituents discussed, irrespective of the combination referred to.

147475.doc -33. 201043139

Ο

147475.doc -34- 201043139

Table 1 is a compound of the formula L1 wherein R1, R2, L1, [2, ^ and are the compounds. The combination corresponds in each case to one of the columns of Table A, and R4 is Η Table 2 Formula h 1 compound, wherein the mouths of the compounds R1, R2, L1, L2, L3 and L4 correspond in each case to one of the tables A And R4 is a methyl hydrazone 3 j1.1 compound, wherein the compound of the ruler 1, r2, L1, L2, [3 and [4 in each case corresponds to one of the tables A, and R4 is an ethyl group The combination of L1 compounds in each case Table 5 'where the compounds R1, R2, L1, L2, L3 & L4 correspond to one of the columns of Table A, and R4 is propyl^-L3, and L^ should be in one of Table A And R4 is isopropyl 147475.doc -35- 201043139 Table 6 Formula L1 compound, wherein the combination of compounds 2R1, r2, L1, l2, 匕3 and 匕4 corresponds in each case to one of Table A, and R4 Is a n-butyl group 7 ^ Formula 1.1 compound, wherein the compound of the ruler 1, r2, Ll, 匕 3 and [4 combination in each case corresponds to one of the tables A, and R4 is the second butyl table 8 ^ a compound of the formula 1.1, wherein the compound R1, r2, L], [2, [3 and ^4 combinations in each case correspond to one of the tables A, and R4 is an isobutyl group 9 formula 1.1 compound 'wherein the compound Rl The combination of r2, L1, L2, ^ and ^ corresponds in each case to one of the columns of Table A, and R4 is a compound of the third butyl group 10 formula L1, wherein the compounds are R1, R2, L1, L2, L3 and L4 The combination corresponds in each case to one of the columns of Table A, and R4 is a phenyl group. The compound of formula 1 wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to Table A. One column, and R4 is a 4-mercaptophenyl group, the compound of the formula 1.1, wherein the compound is a ruler 1, r2, Li, L2. And combinations thereof correspond in each case to one of the columns of Table A, and R4 is Li+ Table 13 Formula 1.1 compound, wherein the combination of the compound of the compound 1, R2, L1, L2, L3 and [4 corresponds to the table in each case. Column A, and R4 is Na+ 147475.doc -36- 201043139 Table 14 Formula L1 compound 'where R1, R2, L1, L2, L3 and L4 of the compound, and S corresponds to Table A in each month One column, and R4 is κ+ Table 15 Formula L1 Compound 'where R1, R2, L1, L2, L3 and L4 of the compound, and the mouth corresponds to one of the tables A in each case, and r/ is 2Mg2+ A compound of the formula U wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to one of the columns of Table A, and the rule 4 is 1/2 (: 112 + Table 17 formula. 'wherein the R1, R2, L1, L2, L3 and L4 of the compound' and the 〇 in each case corresponds to one of the tables A, and the rule 4 is ι/2Ζη2+. Table 18 The compound of the formula 1.1 wherein the compound Ri, r2 , L1, L2, L3, and L4, and 〇 in each case corresponds to one of the columns of Table A, and R4 is i/2Fe2+, a compound of the formula 19, wherein the compound is r!, R2, L1, L2, &quot; ^之And σ corresponds to one of the tables in each case, and the ruler 4 is i/2Ni2+. Table 20 Formula 1, Compound 1 where the compound R1, R2, L1, L2, L3 and L4 are in each case. The lower one corresponds to one of the columns of Table A, and R4 is nH(CH3)3 + Table 21 Formula Ϊ.1 compound, wherein the group of compounds, R2, L1, L2, L3 and L4 corresponds to Table A in each case. One column, and r4 is NH(C2H5)3+ 147475.doc -37- 201043139 Table 22 Compound of formula 1.1, wherein the combination of R1 of the compound corresponds in each case to the compound of formula NH(CH2CH2CH2)3+, Table 23, wherein The combination of the compounds ri corresponds in each case to the table nh(ch(ch3)2)3+ Table 24 The compound of the formula 1.1 wherein the combination of the compounds Ri corresponds in each case to the table nh(ch2ch2ch2ch2)3+ 1.1 A compound wherein the ri of the compound, in each case corresponds to a compound of the formula 26 in Table A, wherein the ri of the compound, in each case corresponds to a compound of the formula 27 in the form of a formula A, wherein the compound Rl, the combination corresponds in each case to a compound of the formula 28 in the formula A, wherein the ri of the compound is combined In this case, it corresponds to one of columns 147475.doc, R2, Li, L2, L3, and L4 A in Table A, and R4 is one of columns R2, 1/, L2, L3, and L4 A, and R4 is R2, R2. /, L2 'L3 and L4 A, and R4 is R2, L!, L2, and L4, and R4 is a fluorenylcarbonyl group R2, 1/, L2, L3, and L4, and R4 is an ethylcarbonyl group R2 And L1, L2, L3 and L4 and R4 are propylcarbonyl R2, L1, L2, L3 and L4 and R is isopropyl tracing-38-201043139 Table 29 Formula Ι·1 compound, wherein compound R1, R2, Ll, ρρ and combinations thereof correspond in each case to one of the columns of Table A and R4 is a compound of the formula 1.1, wherein the combination of the compounds R1, R2, L1, L2, L3 and L4 In each case corresponds to one of the columns of Table A, and R4 is an ethoxycarbonyl table 31 Ο

a compound of the formula 1.1 wherein the compound of the rule 1, R2, L1, 匕2, [3 and [4 combinations in each case corresponds to one of the tables A, and R4 is a propoxycarbonyl group 32^ a compound of the formula 1.1, wherein the compound Then, the combination of R1, R2, L1, L2, [3 and [4 corresponds in each case to one of the tables A, and R4 is a compound of the formula isopropoxycarbonyl group 33, wherein the compound, r2, Li , l2, &quot; and "the combination in each case corresponds to one of the tables A, and Μ is a phenoxycarbonyl group of the formula 34 compound, wherein the compound of the rule 1, R2, Ll, L2, &quot; and "group σ In each case corresponds to one of the columns of Table A, and R4 is a methylaminocarbonyl group 35 compound of the formula U, wherein the group of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to Table A One of the columns, and R4 is ethylaminocarbonyl. Table 36 Compound of formula 1.1 ' wherein R1, R2, L1, L2, L3 and L4 of the compound, 〇 in each case corresponds to one of Table A, and R4 is propyl Aminocarbonyl 147475.doc -39- 201043139 Table 37 Compound of formula 1.1 wherein the combination of R丨, R2, L1, L2, L3 and L4 of the compound corresponds in each case to a column of Table A, and R4 is an isopropylaminocarbonyl group of the compound of formula 1.1 wherein R1, r2, L1, &quot; of the compound, and combinations thereof, in each case correspond to one of Table A, and R4 is Phenylaminocarbonyl Table 39 Compound of formula 1.1 wherein the combination of R1, r2, L1, L2, ^ and ^ of the compound corresponds in each case to one of Table A, and R4 is a methylsulfonyl group. Wherein the combination of R1, R2, L1 'L2, L3 and L4 of the compound corresponds in each case to one of the columns of Table A, and R4 is an ethylsulfonyl group, and the compound of the formula, wherein R1, r2, The combination of L1, L2, L3 &amp; L4 corresponds in each case to one of the columns of Table A, and r4 is a compound of the formula L1, wherein the combination of R1, R2, L1, P, L3 and L4 of the compound is In each case corresponds to one of the columns of Table A, and R4 is a compound of the formula U of the isopropylsulfonyl group, wherein the combination of the compounds R1, R2, L1, L2, L3 and L4 corresponds in each case to one of the tables A And r4 is a phenylsulfonyl group of the compound of the formula U, wherein the compound is R1, R2, L], L2, ρ and . In each case, it corresponds to the column of Table 8, and the rule 4 is methoxysulfonyl 147475.doc -40- 201043139 Table 45 R2 ' L1 ^ T 2 T 3 Λ L, L3 and L4 1 and R4 is ethoxysulfonyl R2, L1, L2, L3 and L4 and R is a propoxysulfonyl formula 1.1 compound wherein the Ri combination of the compounds corresponds in each case to one of the tables A. Compounds in which the Ri combination of compounds correspond in each case to list 47 of Table A Ο

A compound of the formula U wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to one of the columns of Table 8, and R4 is isopropoxysulfonyl, and the formula 48 is Ι·1 The compound, wherein the combination of the ruler 1, r2, L, l2, ^ and "in the case corresponds to the column of Table A, and the phenoxy group is a compound of the formula. The combination of R1, R2, L1, L2, L3 and L4 corresponds in each case to one of the columns of Table A, and R4 is a compound of the formula L2, wherein the compounds are R1, R2, L1, L2, L3 and L4. The combination in each case corresponds to one of the columns of Table 8 and R4 is as defined in any of Tables 99 to 147, the compound of formula 1.3, wherein the compound is in the range of 丨, r2, L1, L2, L3 and The broad group 0 corresponds in each case to one of the columns of Table A and R4 is as defined in any of Tables 1 to 49, in the formula 148 to 196 147475.doc 201043139, the compound of the formula L4, wherein the compound R1, R2, L1 , Τ 2 τ 3 a τ L, L and L combinations in each case correspond to one of the columns and R4 is as defined in any of Tables 1 to H, Tables 197 to 245 a compound of 1.5, wherein the combination of the compound, r2, L1, l2, ^ and "in each case corresponds to one of the columns of Table A and the ruler 4 is as defined in any of Tables 246 to 294. The compound of formula 1.6 wherein the combination of R1, r2, B1 2 3 l, L· and L· of the compound corresponds in each case to one of the columns of Table A and R 4 is as in any of Tables 1 to H. The combination of R1, r2, ^1, T2 3 a τ 4 h L, L and L of the compound of formula 295 to 343 of formula 295 to 343 is defined in each case corresponding to one of the tables a and R 4 is as shown in the table. ! Tables 344 to 392 of formula 1.8 as defined in any one of 4' wherein the combination of R1, r2丨τ 3 α τ 4 ι L, L and L of the compound corresponds in each case to one of Table A and] ^ is a compound of formula 393, formula 1.9 as defined in any of Tables 1 to 49, wherein the combination of R1, r2, Ll τ 3 β τ 4 ^ ι, L and L of the compound corresponds in each case to the expression A list of compounds of formula 1.10, wherein the combination of compounds R1, R2, L1, l2, ^, and 匕4 147475.doc-42-201043139 corresponds in each case to one of Table A, List 395, Formula Ι11 compounds, Wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to the list 396 ' of the formula 1-12 compound, wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound is In each case corresponds to a list 397 of the formula A, a compound of formula 1.13, wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to the compound of the formula 144, formula 1.14, wherein the compound The combination of 111, 112, 1^1, 1^, 1^3, and 1 in each case corresponds to one of the tables A, 399, and the formula 1.15. Wherein the combination of 111, 112, [1, 1^2, B3, and 1/0 of the compound corresponds in each case to the compound of formula 1.16 of Table A, wherein 111, 112, 1^1 of the compound The combination of 12, 1^3 and 1/• corresponds in each case to the compound of formula ll. II.1 of Table A, wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case. Listed in one of Table A and 1143 is a group of the formula .1, wherein the compound is R1, R2, L1, L2, L3 and L4 147475.doc-43 201043139. In each case corresponds to one of the columns of Table A and R4a is a thiol table 403 Formula 1 compound wherein the combination of R1, R2, L1, L2' L3 and L4 of the compound corresponds in each case to one of the columns of Table A and is Ethyl table 404 is a compound of the formula 1.1, wherein the compound is, r2, L1, l2, &quot; and, and a in each case corresponds to one of the columns of Table A and R4a is a propyl form 405 Formula II. A compound wherein the compound is ..., r2, L1, l2. The group σ of ^ and ^ corresponds in each case to one of the columns of Table a and R4a is an isopropyl group 406. The compound of the formula ,.1, wherein the compound is R1, r2, L1, y. And combinations thereof in each case correspond to one of the tables a and Rh is a n-butyl group 407. The compound of the formula II.1, wherein the combination of the ruler 1, r2, L1, L2, L3 and L4 of the compound corresponds in each case In a column of Table A and R 4 a is a second butyl group 408 compound of formula IL1 wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to one of the columns of Table A and R4a is different. Butyl Table 409 Compound of formula II.1 wherein the combination of R1, r2, L1, L2, [3 and L4 of the compound corresponds in each case to one of Table A and R4a is a third butyl group. a compound wherein the combination of R1, r2, L2, L3 and 14 147475.doc • 44- 201043139 of the compound corresponds in each case to one of the columns of Table A and R 4a is a phenyl group 411. The compound of the formula II. The combination of ri, r2, [I, l2, l3 and L4 corresponds in each case to one of the columns of Table A and R4a is a 4-methylphenyl group 412 compound of the formula II.1, wherein the compound ri, r2, The combination of l2, l3 and L·4 corresponds in each case to one of the columns of Table A and R4a is a methyl group table 413 化合物 a compound of the formula II.1, wherein the compound R1, r2, L2 The combination of L3 and L4 correspond in each case to one row of Table A and R4a is ethylcarbonyl Table II.1 compound of Formula 414 'of the compound wherein Rl, r2, L1, L2 ,. The combination of L4 and L4 corresponds in each case to one of the columns of Table A and R "is a propylcarbonyl table 415 compound of formula IL1" wherein the combination of R1, R2, L1, L2, L3 and L4 Q of the compound corresponds in each case to Column A and R4a are isopropylcarbonyl Table 416 Formula IL1 compound 'wherein the combination of R1, R2, L1, L2, L3 and L4 - of the compound corresponds in each case to one of Table A and R4a is methoxycarbonyl Table 417 Compounds of the formula IL1 wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to one of the columns of Table A and R4a is ethoxycarbonyl table 418, L1, L2, L3 and L4 The compound of the formula 1, wherein the combination of the compound Ri, r2 147475.doc -45- 201043139 corresponds in each case to one of the columns of Table A and R4a is a propoxycarbonyl group 419. The compound of the formula IL1 wherein R1, R2, L1 of the compound The combination of L2, L3 and L4 corresponds in each case to one of the columns of Table A and R4a is a compound of formula 1 of isopropoxycarbonyl table 420, wherein the combination of R, R2, L1, L2, L3 and L4 of the compound is in each case. The lower one corresponds to one of the columns of Table A and R4a is a phenoxycarbonyl group 421. The compound of the formula IL1, wherein the compound R1, R2 The combination of L1, L2, L3 and L4 corresponds in each case to one of the columns of Table A and R4a is a methylaminocarbonyl group 422 formula Π.1 compound wherein R1, R2, L, L2, [3 and The combination of L4 corresponds in each case to one of the columns of Table 8 and R4a is a compound of the formula II.1 of the ethylaminocarbonyl group, wherein the combination of the compounds R1, r2, L1, L2, [3 and [4 in each case) The lower one corresponds to one of the columns and R4a is a propylaminocarbonyl group 424. The compound of formula IL1' wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to one of the columns of Table A and R 4 a is an isopropylaminocarbonyl group 425 compound of the formula IL1 wherein the combination of the compounds Ri' R2, l1, L2, L3 and L·4 corresponds in each case to one of the columns of Table A and R4a is a phenylaminocarbonyl group. Table 426 Compounds of the formula IL1, wherein the combination of the compounds Ri, R2, L1, L2, L3 and L·4 147475.doc • 46· 201043139 corresponds in each case to one of the tables A and the Han 4 base table 427 formula IL1 a compound wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to the taberin-column and R4a is the base table 428 'H·1 5, wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to one of the columns of Table A and R4a is a compound of the formula 439 〇 Π·1, wherein the compound The combination of r2, L1, 匕2, l3&amp;l4 corresponds in each case to one of the columns of Table A and R4a is a compound of the formula 430, wherein the compounds are R1, R2, L1, L2, L3 and L4. The combination in each case corresponds to one of the columns of Table A and is a compound of the formula 4-1, formula II.1, wherein the combination of the compound Ri, R2, 匕1, [2, l3 and l4 在 corresponds in each case Included in Table A and R4a is a methoxysulfonyl group 432 Formula Π 1 compound 'wherein the combination of R1, r2, L1, l2, [3 and L4 - of the compound corresponds in each case to one of Table A And the ruler "is a compound of the formula 433 Π.1, wherein the compound of the formula R, R2, [I, [2, l3 &amp; l4 combination in each case corresponds to one of the table A and R4a is Propoxy sulfonyl group 434 Formula II.1 compound 'wherein the compound R1, r2, L1, L2, 13 and 147475.doc -47- 201043139 combination in each case corresponds to And a combination of R丨, R2, L1, L2, L3 and L4 of the compound in each case corresponds to one of the tables A, and R 4 a is an isopropoxysulfonyl group 435 formula IL1 compound The reverse is "phenoxysulfonyl group 436 formula IL1 compound" wherein the combination of compounds R1, R2, L1, L2, L3 and L4 corresponds in each case to one of the columns of Table A and R4a is CN Tables 437 to 472 A compound of Π.2, wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to one of the columns and the ruler "is as defined in any of Tables 401 to 436. The combination of R1, R2, L1, L2, L3 and L4 of the compound 508 is in each case corresponding to one of the columns and R4a is as defined in any of Tables 401 to 436. Table 509 to 544 Compounds of the formula ,4, wherein the combination of R1, R2, L丨, L2, L3 and L4 of the compound corresponds in each case to one of the columns and R4a is as in Tables 〇1 to 436. Tables 545 to 580 are defined as compounds of formula 545 to 580, wherein the combination of Ri, R2, L1, l2, l3 and L4 of the compound corresponds in each case to one of the columns of Table A and R4a Tables 581 to 616 147475.doc • 48 · 201043139 Compounds of the formula II.6, wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound is in each of Tables 〇1 to 436 In the case of a column corresponding to Table A and R4aS, as defined in any of Tables 401 to 436, a compound of the formula 617 to 652, wherein a combination of R1, R2, L1, L2, L3 and L4 of the compound is Each case corresponds to one of the columns and 1143 is as defined in any of Tables 401 to 436, tables 653 to 688

A compound of formula II.8 wherein the combination of R1, R2, L1, L2, L3 and L4 of the compound corresponds in each case to one of the columns of Table A and Rule 43 is as defined in any of Tables 401 to 436. A

No. R1 R2 L1 L2 L3 L4 A-1. ch3 ch3 FHHH A-2. ch3 ch3 Br HHH A-3. ch3 ch3 ch3 HHH A-4. ch3 ch3 CH2CH3 HHH A-5. ch3 ch3 CH(CH3)2 HHH A-6. ch3 ch3 cf3 HHH A-7. ch3 ch3 CH2CF3 HHH A-8. ch3 ch3 CF2CHF2 HHH A-9. ch3 ch3 OCF3 HHH A-10. ch3 ch3 OCH2CF3 HHH A-11. ch3 ch3 och3 HHH A- 12. ch3 ch3 OCH2CH3 HHH A-13. ch3 ch3 F Cl HH A-14. ch3 ch3 FH Cl H A-15. ch3 ch3 ch3 H Cl H A-16. ch3 ch3 CH2CH3 H Cl H A-17. ch3 ch3 CH(CH3)2 H Cl H A-18. ch3 ch3 cf3 H Cl H A-19. ch3 ch3 CH2CF3 H Cl H A-20. ch3 ch3 CF2CHF2 H Cl H A-21. ch3 ch3 OCF3 H Cl H A- 22. ch3 ch3 OCH2CF3 H Cl H A-23. ch3 ch3 OCH3 H Cl H 147475.doc •49- 201043139

No. R1 R2 L1 L2 L3 L4 A-24. ch3 ch3 OCH2CH3 H Cl H A-25. ch3 ch3 ch3 Cl HH A-26. ch3 ch3 CH2CH3 Cl HH A-27. ch3 ch3 ch(ch3)2 Cl HH A- 28. ch3 ch3 cf3 Cl HH A-29. ch3 ch3 ch2cf3 Cl HH A-30. ch3 ch3 cf2chf2 Cl HH A-31. ch3 ch3 ocf3 Cl HH A-32. ch3 ch3 OCH2CF3 Cl HH A-33. ch3 ch3 OCH3 Cl HH A-34. ch3 ch3 OCH2CH3 Cl HH A-35. H ch3 FHHH A-36. H ch3 Br HHH A-37. H ch3 ch3 HHH A-38. H ch3 ch2ch3 HHH A-39. H ch3 CH( CH3)2 HHH A-40. H ch3 cf3 HHH A-41. H ch3 CH2CF3 HHH A-42. H ch3 CF2CHF2 HHH A-43. H ch3 OCF3 HHH A-44. H ch3 OCH2CF3 HHH A-45. H ch3 0 CH3 HHH A-46. H ch3 OCH2CH3 HHH A-47. H ch3 F Cl HH A-48. H ch3 FH Cl H A-49. H ch3 ch3 H Cl H A-50. H ch3 CH2CH3 H Cl H A- H ch3 CH(CH3)2 H Cl H A-52. H ch3 cf3 H Cl H A-53. H ch3 CH2CF3 H Cl H A-54. H ch3 CF2CHF2 H Cl H A-55. H ch3 OCF3 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ch3 CH2CF3 Cl HH A-64. H ch3 cf2chf2 Cl HH A-65. H ch3 ocf3 Cl HH A- 66. H ch3 OCH2CF3 Cl HH A-67. H ch3 OCH3 Cl HH A-68. H ch3 OCH2CH3 Cl HH A-69. HHFHHH A-70. HH Br HHH A-71. HH ch3 HHH 147475.doc -50- 201043139

HR CH2CH3 HHH A-73. HH cf3 HHH A-74. HH CH2CF3 HH OCH3 HHH A-78. HH OCH3 HHH A-80. HH OCH2 HHH A-80. HH OCH2CH3 HHH A-81. HHF Cl HH A-82. HHFH Cl H A-83. HH ch3 H Cl H A-84 HH CH2CH3 H Cl H A-85. HH CH(CH3)2 H Cl H A-86. HH cf3 H Cl H A-87. HH CH2CF3 H Cl H A-88. HH CF2CHF2 H Cl H A-89. HH OCH3 HCH H A-91. HH OCH3 H Cl H A-92. HH OCH2CH3 H Cl H A-93. HH ch3 Cl HH A-94. HH CH2CH3 Cl HH A- HH cf3 Cl HH A-97. HH cf2chf2 Cl HH A-99. HH ocf3 Cl HH A-100. HH OCH2CF3 Cl HH H-OCH2Cl HH A-103. H cf3 FHHH A-104. H cf3 Br HHH A-105. H cf3 ch3 HHH A-106. H cf3 CH2CH3 HHH A-107 H cf3 ch(ch3)2 HHH A-108. H cf3 cf3 HHH A-109. H cf3 CH2CF3 HHH A-110. H cf3 cf2chf2 HHH A-lll. H cf3 ocf3 HHH H cf3 OCH3 HHH A-114. H cf3 OCH2CH3 HHH A-115. H cf3 F Cl HH A-116. H cf3 FH Cl H A-117. H cf3 ch3 H Cl H A-118. H cf3 CH2CH3 H Cl H A-119. H cf3 CH(CH3)2 H Cl H 147475.doc •51 . 201043139

No. R1 R2 L1 L2 L3 L4 A-120. H cf3 cf3 H Cl H A-121. H cf3 ch2cf3 H Cl H A-122. H cf3 CF2CHF2 H Cl H A-123. H cf3 OCF3 H Cl H A-124 H cf3 OCH2CF3 H Cl H A-125. H cf3 0CH3 H Cl H A-126. H cf3 OCH2CH3 H Cl H A-127. H cf3 ch3 Cl HH A-128. H cf3 CH2CH3 Cl HH A-129. H Cf3 ch(ch3)2 Cl HH A-130. H cf3 cf3 Cl HH A-131. H cf3 ch2cf3 Cl HH A-132. H cf3 CF2CHF2 Cl HH A-133. H cf3 OCF3 Cl HH A-134. H cf3 H CH2CH3 Cl HH A-137. H CH2CH3 FHHH A-138. H CH2CH3 Br HHH A-139. H CH2CH3 ch3 HHH A-140. H CH2CH3 CH2CH3 HHH A-141. H CH2CH3 CH(CH3)2 HHH A-142. H CH2CH3 cf3 HHH A-143. H CH2CH3 CH2CF3 HHH A-144. H CH2CH3 CF2CHF2 HHH A-145. H CH2CH3 OCF3 HHH A-146. H CH2CH3 OCH2CF3 HHH A-147. H CH2CH3 och3 HHH A-148. H CH2CH3 OCH2CH3 HHH A-149. H CH2CH3 F Cl HH A-150. H ch2ch3 FH Cl H A-151. H CH2CH3 ch3 H Cl H A- 152. H CH2CH3 CH2CH3 H Cl H A-153. H CH2CH3 ch(ch3)2 H Cl H A-154. H CH2CH3 c H CH2CH3 CH2CHF2 H Cl H A-157. H CH2CH3 OCF3 H Cl H A-158. H CH2CH3 OCH2CF3 H Cl H A-159. H CH2CH3 OCH3 H Cl H A-160. H CH2CH3 OCH2CH3 H Cl H A-161. H CH2CH3 ch3 Cl HH A-162. H CH2CH3 CH2CH3 Cl HH A-163. H CH2CH3 CH(CH3)2 Cl HH A-164. HCH2CH3 CH2CF3 Cl HH A-166. H CH2CH3 cf2chf2 Cl HH A-167. H CH2CH3 ocf3 Cl HH 147475.doc -52- 201043139

No. R1 R2 L1 L2 L3 L4 A-168. H CH2CH3 OCH2CF3 Cl HH A-169. H CH2CH3 OCH3 Cl HH A-170. H CH2CH3 OCH2CH3 Cl HH A-171. ch3 cf3 FHHH A-172. ch3 cf3 Br HHH A -173. ch3 cf3 ch3 HHH A-174. ch3 cf3 CH2CH3 HHH A-175. ch3 cf3 CH(CH3)2 HHH A-176. ch3 cf3 cf3 HHH A-177. ch3 cf3 CH2CF3 HHH A-178. ch3 cf3 CF2CHF2 HHH A-179. ch3 cf3 OCF3 HHH A-180. ch3 cf3 OCH2CF3 HHH A-181. ch3 cf3 OCH3 HHH A-182. ch3 cf3 OCH2CH3 HHH A-183. ch3 cf3 F Cl HH A-184. ch3 cf3 FH Cl H A-185. ch3 cf3 ch3 H Cl H A-186. ch3 cf3 CH2CH3 H Cl H A-187. ch3 cf3 CH(CH3)2 H Cl H A-188. ch3 cf3 cf3 H Cl H A-189. ch3 Cf3 CH2CF3 H Cl H A-190. ch3 cf3 CF2CHF2 H Cl H A-191. ch3 cf3 OCF3 H Cl H A-192. ch3 cf3 OCH2CF3 H Cl H A-193. ch3 cf3 OCH3 H Cl H A-194. ch3 Cf3 OCH2CH3 H Cl H A-195. ch3 cf3 ch3 Cl HH A-196. ch3 cf3 CH2CH3 Cl HH A-197. ch3 cf3 CH(CH3)2 Cl HH A-198. ch3 cf3 cf3 Cl HH A-199. ch3 Cf3 CH2CF3 Cl HH A-200' ch3 cf3 CF2CHF2 Cl HH A-201. ch3 cf3 OCF3 Cl HH A-202. ch3 cf3 OCH2CF3 Cl HH A-203. ch3 cf3 OCH3 Cl HH A-204. ch3 cf3 OCH2CH3 Cl HH A-205. ch3 CH2CH3 FHHH A-206. ch3 CH2CH3 Br HHH A-207. ch3 CH2CH3 ch3 HHH A-208. ch3 ch2ch3 CH2CH3 HHH A-209. ch3 CH2CH3 CH(CH3)2 HHH A-210. ch3 CH2CH3 cf3 HHH A-211. ch3 ch2ch3 ch2cf3 HHH A-212. ch3 CH2CH3 CF2CHF2 HHH A-213. CH2CH3 OCF3 HHH A-214. ch3 CH2CH3 OCH2CF3 HHH A-215. ch3 CH2CH3 OCH3 HHH 147475.doc -53- 201043139

No. R1 R2 L1 L2 L3 L4 A-216. ch3 CH2CH3 OCH2CH3 HHH A-217. ch3 CH2CH3 F Cl HH A-218. ch3 CH2CH3 FH Cl H A-219. ch3 CH2CH3 ch3 H Cl H A-220. ch3 CH2CH3 CH2CH3 CH3CH2CH3 CH(CH3)2HClH A-222. ch3 CH2CH3 cf3 H Cl H A-223. ch3 CH2CH3 CH2CF3 H Cl H A-224. ch3 CH2CH3 CF2CHF2 H Cl H A-225 Ch3 CH2CH3 OCF3 H Cl H A-226. ch3 CH2CH3 OCH2CF3 H Cl H A-227. ch3 CH2CH3 OCH3 H Cl H A-228. ch3 CH2CH3 OCH2CH3 H Cl H A-229. ch3 CH2CH3 ch3 Cl HH A-230. Ch3 CH2CH3 CH2CH3 Cl HH A-231. ch3 CH2CH3 CH(CH3)2 Cl HH A-232. ch3 CH2CH3 cf3 Cl HH A-233. ch3 CH2CH3 ch2cf3 Cl HH A-234. ch3 CH2CH3 CF2CHF2 Cl HH A-235. CH2CH3 OCF3 Cl HH A-236. ch3 ch2ch3 OCH2CF3 Cl HH A-237. ch3 CH2CH3 OCH3 Cl HH A-238. ch3 CH2CH3 OCH2CH3 Cl HH A-239. cf3 cf3 FHHH A-240. cf3 cf3 Br HHH A-241. Cf3 cf3 ch3 HHH A-242. cf3 cf3 CH2CH3 HHH A-243. cf3 cf3 ch(ch3)2 HHH A-244. cf3 cf3 cf3 HHH A-245. cf3 cf3 CH2CF3 HHH A-246. cf3 cf3 CF2CHF2 HHH A- 247. cf3 cf3 OCF3 HHH A-248. cf3 cf3 OCH2CF3 HHH A-249. cf3 cf3 OCH3 HHH A-250. cf3 cf3 OCH2CH3 HHH A-251. cf3 cf3 F Cl HH A-252. cf3 cf3 FH Cl H A-253. cf3 cf3 Ch3 H Cl H A-254. cf3 cf3 CH2CH3 H Cl H A-255. cf3 cf3 CH(CH3)2 H Cl H A-256. cf3 cf3 cf3 H Cl H A-257. cf3 cf3 CH2CF3 H Cl H A- 258. cf3 cf3 CF2CHF2 H Cl H A-259. cf3 cf3 OCF3 H Cl H A-260. cf3 cf3 OCH2CF3 H Cl H A-261. cf3 cf3 OCH3 H Cl H A-262. cf3 cf3 OCH2CH3 H Cl H A- 263. cf3 cf3 ch3 Cl HH 147475.doc -54- 201043139

No. R1 R2 L1 L2 L3 L4 A-264. cf3 cf3 CH2CH3 Cl HH A-265. cf3 cf3 CH(CH3)2 Cl HH A-266. cf3 cf3 cf3 Cl HH A-267. cf3 cf3 CH2CF3 Cl HH A-268 Cf3 cf3 CF2CHF2 Cl HH A-269. cf3 cf3 OCF3 Cl HH A-270. cf3 cf3 OCH2CF3 Cl HH A-271. cf3 cf3 och3 Cl HH A-272. cf3 cf3 OCH2CH3 Cl HH A-273. cf3 CH2CH3 FHHH A - 274. cf3 CH2CH3 Br HHH A-275. cf3 CH2CH3 ch3 HHH A-276. cf3 CH2CH3 CH2CH3 HHH A-277. cf3 CH2CH3 CH(CH3)2 HHH A-278. cf3 CH2CH3 cf3 HHH A-279. cf3 CH2CH3 ch2cf3 HHH A-280. cf3 CH2CH3 cf2chf2 HHH A-281. cf3 CH2CH3 ocf3 HHH A-282. cf3 CH2CH3 OCH2CF3 HHH A-283. cf3 CH2CH3 OCH3 HHH A-284. cf3 CH2CH3 OCH2CH3 HHH A-285. cf3 CH2CH3 F Cl HH A-286. cf3 CH2CH3 FH Cl H A-287. cf3 CH2CH3 ch3 H Cl H A-288. cf3 CH2CH3 CH2CH3 H Cl H A-289. cf3 ch2ch3 ch(ch3)2 H Cl H A-290. cf3 CH2CH3 cf3 H Cl H A-291. cf3 CH2CH3 CH2CF3 H Cl H A-292. cf3 ch2ch3 CF2CHF2 H Cl H A-293. cf3 CH2CH3 OCF3 H Cl H A-294. cf3 CH2CH3 OCH2CF3 H Cl H A-295. cf3 CH2CH3 OC H3 H Cl H A-296. cf3 CH2CH3 OCH2CH3 H Cl H A-297. cf3 CH2CH3 ch3 Cl HH A-298. cf3 CH2CH3 CH2CH3 Cl HH A-299. cf3 CH2CH3 CH(CH3)2 Cl HH A-300. cf3 CH2CH3 cf3 Cl HH A-301. cf3 CH2CH3 CH2CF3 Cl HH A-302. cf3 CH2CH3 cf2chf2 Cl HH A-303. cf3 CH2CH3 ocf3 Cl HH A-304. cf3 CH2CH3 OCH2CF3 Cl HH A-305. cf3 CH2CH3 OCH3 Cl HH A -306. cf3 CH2CH3 OCH2CH3 Cl HH A-307. CH2CH3 CH2CH3 FHHH A-308. CH2CH3 CH2CH3 Br HHH A-309. CH2CH3 CH2CH3 ch3 HHH A-310. CH2CH3 CH2CH3 CH2CH3 HHH A-311. CH2CH3 CH2CH3 ch(ch3)2 HHH 147475.doc -55- 201043139

No. R1 R2 L1 L2 L3 L4 Α-312. CH2CH3 CH2CH3 cf3 HHH Α-313. CH2CH3 CH2CH3 ch2cf3 HHH Α-314. CH2CH3 CH2CH3 CF2CHF2 HHH Α-315. CH2CH3 CH2CH3 OCF3 HHH Α-316. CH2CH3 CH2CH3 OCH2CF3 HHH Α-317 CH2CH3 CH2CH3 och3 HHH Α-318. CH2CH3 ch2ch3 OCH2CH3 HHH Α-319. CH2CH3 CH2CH3 FCl HH Α-320. CH2CH3 CH2CH3 FH Cl H Α-321. CH2CH3 CH2CH3 ch3 H Cl H Α-322. CH2CH3 ch2ch3 CH2CH3 H Cl H Α-323. CH2CH3 CH2CH3 ch(ch3)2 H Cl H Α-324. CH2CH3 CH2CH3 cf3 H Cl H Α-325. CH2CH3 CH2CH3 CH2CF3 H Cl H Α-326. CH2CH3 CH2CH3 CF2CHF2 H Cl H Α-327. ch2ch3 CH2CH3 OCF3 H Cl H Α-328. CH2CH3 CH2CH3 OCH2CF3 H Cl H Α-329. ch2ch3 CH2CH3 OCH3 H Cl H Α-330. CH2CH3 CH2CH3 OCH2CH3 H Cl H Α-331. ch2ch3 CH2CH3 ch3 Cl HH Α-332. CH2CH3 CH2CH3 Ch2ch3 Cl HH Α-333. CH2CH3 CH2CH3 CH(CH3)2 Cl HH Α-334. ch2ch3 CH2CH3 cf3 Cl HH Α-335. ch2ch3 CH2CH3 CH2CF3 Cl HH Α-336. CH2CH3 CH2CH3 CF2CHF2 Cl HH Α-337. ch2ch3 CH2CH3 OCF3 Cl HH Α-338. CH2CH3 CH2CH3 OCH2CF3 Cl HH Α-33 9. ch2ch3 CH2CH3 OCH3 Cl HH Α-340. CH2CH3 CH2CH3 OCH2CH3 Cl HH The compounds of formula I and formula II can be obtained by one or more of the following methods and variations as described below in Schemes 1 to 13 and in the synthetic description. preparation. The variables are as defined above for Formula I and Formula II. The compound of formula IA can be prepared by vulcanizing the corresponding triazole derivative 7 as outlined in Scheme 1, wherein R4 is deuterium and η is 0 (=compound IA') (or compound 11 VIII, where ft 4&quot; is 11) . Vulcanization can be carried out similarly to the known methods described, for example, in \¥0 96/3 8423. For example, a strong base (for example, an organic lithium base such as n-butyllithium, a third butyllithium or a second butyllithium, a lithium diisopropylamide, a sodium hydride, a sodium azide or a third may be used first. Potassium butoxide and tetramethylethyl 147475.doc • 56· 201043139 The di-sial ring is deprotonated, and then the sulfur is generally used in powder form. The bond 'eg diethyl ether, methyl tert-butyl monoamine (TMEDA) The mixture of the resulting anion is reacted with elemental sulfur. The reaction is generally carried out in an inert solvent such as tetrahydrofuran or H, dimethoxyethane, liquid ammonia, dimethylhydrazine or dimethylformamide. ;5,, reaction / dish is not very critical and can be found in Ο

For example, -7 generations to +50. (:, preferably in the range of iron to the next. Or, in the absence of the test, by heating 7 while the elemental sulfur is in a high-point solvent (such as Ν-methyl ketone, two chewing or Vulcanization is carried out by reaction in hydrazine, hydrazine-dimethyl dimethylamine. After completion of the reaction, for example, by adding water or an aqueous acid solution such as a mineral acid (for example, dilute sulfuric acid or hydrochloric acid), acetic acid or ammonium sulfate, The resulting mixture is hydrolyzed to give the compound. The compound III can be prepared analogously to the known methods such as those described in ερ_α_0267778. For example, the epoxy ethene compound can be converted to a servone 1 Η-triazole in the presence of a base. In reaction, the base is such as an alkali metal hydride (e.g., sodium hydride, potassium hydride), an alkali metal hydroxide (e.g., sodium hydroxide, potassium hydroxide) or an alkali metal carbonate (e.g., sodium carbonate, potassium carbonate, carbonic acid). The reaction is suitably carried out in a solvent. Suitable solvents are, for example, toluene, hydrazine-methylpyrrolidone, ethers (for example diethyl ether, tetrahydrofuran), acetonitrile or hydrazine, hydrazine-dimethylformamide. It can be similar to, for example, EP-A_0267778. , 〇rg. Sy Ethylene oxide 6 is prepared by a known method described in n 49, 78 (1968) or J. Am. Chem. Soc. 1975, 1353. For example, cyclopentanone 5 and alkylene sulfonium (sulfonate) can be obtained. 〇nium ylide) or ox〇suif〇njum yHde (such as dimethyl fluorenyloxy or monomethylmethylene) is reacted in a solvent. Alternatively, it can be similar to Tetrahedron Lett. 23, 5283 (1982) or EP-A-0655443, 147475.doc • 57· 201043139 The method described in the epoxidation reaction by 5 and trisodium salt (such as trimethyl sulfonium trimethoate, trimethyl hydrazine or barium sulphate) Base three) in metal oxides (such as metal oxides (such as sodium oxide, potassium oxide)' soil metal oxides (such as magnesium oxide, oxygen (four), oxidation (6) or oxidation) and depending on the case (such as metal Hydride (such as sodium hydride, potassium hydride), alkali metal oxychloride (such as sodium oxychloride, potassium hydroxide), alkali metal carbonate (such as sodium carbonate, potassium carbonate, carbonic acid planing) in the presence of organic solvents ( Such as toluene, n-methylpyrrolidone, ether (such as ether, tetrahydrofuran), B Or a two-phase solid/liquid system of n, n-dimethyl carbamide to react to produce ethylene oxide 6. Alternatively, it may be similar to the method described in Tetrahedron 1985, 1259 by trimethyl sulfonium salt ( Such as tribromide bromide, trimethylsulfonium iodide or methyltrimethylsulfate) or sulfoxonium salts (such as trimethylsulfoxonium bromide, dimethylphosphonium iodide or methyltrimethyl sulfate) The ruthenium oxyhydroxide) and the potassium sulphate/oxidized sulphur are epoxidized to prepare the oxirane 6. The cyclopentanone 5 can be obtained by hydrolysis of the cyclopentanone 4 ester and subsequent removal of the carboxyl group. The vinegar can be hydrolyzed under standard conditions, such as by using a suitable base such as an alkali metal hydroxide (such as sodium hydroxide, potassium hydroxide) or an alkali metal carbonate (such as sodium carbonate, potassium carbonate, cesium carbonate) in water. get on. Decarboxylation occurs when the resulting acid is heated in the presence of a test (e.g., one of the above bases;). From cyclopentanone 3 by reacting cyclopentanone 3 with compound R2X (wherein X is a cleavage group such as a halo group (e.g., Cl, Br, I), an anthracenyl sulfonate group or a mesylate group) The reaction is carried out to prepare cyclopentanone 4. Suitable bases are, for example, alkali metal alkoxides (e.g., sodium methoxide, potassium methoxide, sodium methoxide, potassium ethoxide, potassium t-butoxide) and alkali metal hydrides (e.g., sodium hydride, potassium hydride). The reaction is generally 147475.doc -58- 201043139 in a solvent (such as an alcohol (such as decyl alcohol, ethanol), an ether (such as diethyl ether, tetrahydrofuran), N-decylpyrrolidone or n,N-dimercaptocarboxamide) In progress. The cyclopentanone 3 can be prepared from cyclopentanone 1 by alkylating it with compound 2 in the presence of a base, wherein γ is a leaving group, such as a halogen group (e.g., Cl ' Br, I), a phthalic acid ester Base or a thiol group. Suitable for testing, for example, metal alkoxides (e.g., sodium methoxide, potassium methoxide, sodium methoxide, potassium ethoxide, potassium butoxide) and metal hydrides (e.g., sodium hydride, potassium hydride). The reaction is generally carried out in a solvent such as an alcohol (e.g., methanol, ethanol), an ether (e.g., sigma, tetrahydrofuran), N-decyl pi-pyridinone, n, n-dimercaptocaramine or a gas. In decane). Process 1

Suihua

SH

Compound 1 can be prepared analogously to the method described in Scheme 2, J. 0rg. chem. 1983, 48(7), 1125, as described below in Scheme 2, in a Dieckmann condensation in the presence of a base. The diacid 8 is cyclized to 9. Suitable bases are, for example, alkali metal alkoxides (e.g., sodium methoxide, potassium methoxide, methanol 147475.doc - 59. 201043139 Μ ' &amp; potassium alkoxide). The condensation is generally carried out in a solvent (10) such as a leaven (e.g., methanol, ethanol) or a scale (e.g., B-, tetrahydrobine, methylpyrrolidone). Alternatively, in the Lewis acid acid (such as vaporized aluminum or boron tribromide), transition metal salts (such as silver salt, iron salt, copper salt, gold salt, gu salt, starting salt (such as Ag2 〇, AgCi 〇 4, FeCi3, Nici2

CuBr2, CuCl2, Cu(0Ae)2, CuS〇4, μ" and in the presence of an organic lithium base (such as lithium isopropoxide) in a suitable solvent (such as ether (such as acetamidine W) Cyclization is carried out in toluene, N-decylpyrrolidone or di-methane. Subsequent to 9 and compound Rlx (wherein deuterium is a leaving group, such as a functional group (such as Cl, Br, I), tosylate or mesylate group) in a suitable base (such as an alkali metal alkoxide (such as methanol) The reaction is carried out in the presence of sodium, potassium methoxide, sodium methoxide, ethyl, potassium t-butoxide). The home-based reaction is generally carried out in a suitable solvent such as an alcohol (e.g., formazan, 7 amp, ^ ethanol), a shout (e.g., acetamidine, tetrahydrofuran) or N-methylpyrrolidone. Process 2

, 〇R 5 c〇zR test or metal salt w v_y — 9

R1X Ο

•co2r

As an alternative to the method described in Scheme 1, 1 can be as follows (5) S: two: /: 10 and benzene - bio-U under standard conditions in the alcohol two: reaction. The money should generally be in the test condition of metal ruthenium oxide (such as sodium hydroxide, hydrogen oxide = (such as methanol, potassium methoxide, ethanol, ethanol: genus:: metal hydride (such as sodium hydride, alcohol clock) r In a suitable solvent (such as 丨J47475.doc • 60· 201043139 (eg, methanol, ethanol, tert-butanol) or ether (such as tetrahydrofuran). For example, using palladium or nickel catalyst to reduce aldols under standard hydrogenation conditions Condensate 12 gives 5. Flow 3

Compound Yang 10 can be prepared analogously to the method described in Tetrahedron 1998, 54 (28), 8075, as outlined in Scheme 4 below. The 4-butyralaldehyde is reacted with an alkali metal cyanide MtN such as NaCN or KCN to give the corresponding cyanohydrin, which is then protected with hydrazine to give the cyanohydrin ether 13. Cyclization in an ether solvent (eg diethyl ether, tetrahydrofuran) in the presence of a base (especially an organolithium base (eg lithium diisopropylamide) or sodium hexyldiazoxide) affords 14 which is first selectively reduced to 15, then restored to 16. The protecting group for removing the hydroxyl group gives 17 and undergoes an oxidative ring expansion reaction to finally obtain 1 Torr. Process 4

147475.doc -61- 201043139 Alternatively, a compound 1 〇 (=1 〇,) wherein R1 is CH3 can be prepared analogously to the method described in Scheme 5, as described in WO 95/09830. Catalytic C-C coupling of butadiene derivative 18 with acetamidine acetate derivative 17 (wherein Ri is a Cl_c6 alkyl group or an alkoxy group and a CrC6 alkyl group) gives double bond isomers 19 and 20. Suitable catalysts are complexes of ruthenium and phosphine ligands, which are mainly produced from the following sites: ruthenium compounds such as Rh2〇3, RhCl3, RhBr3,

Rh2(S〇4)3, (Rh(CO)4)4, (Rh(CO)2Cl)2, Rh(CH3C02)3,

Rh(N〇3)3 or Rh(C8H]2Cl)2' and a phosphonium salt such as triphenylphosphine, (sulfonylphenyl)diphenylphosphine, bis(sulfophenyl)phenylphosphine or tris(sulfonate) A sodium salt, a potassium salt, a calcium salt, a phosphonium salt, an ammonium salt, a tetramethylammonium salt or a tetraethylammonium salt of an acid phenyl)phosphine. This reaction is generally carried out in a two-phase aqueous/organic solvent system. The addition reaction is preferably carried out in an alkaline &quot;quality to aid in the deprotonation of the methylene group of the acetamidine acetate derivative j7. Suitable bases are, for example, water-soluble inorganic bases such as alkali metal hydroxides (for example sodium hydroxide, potassium hydroxide), carbonates (for example sodium carbonate, potassium cesium carbonate, cesium carbonate) or hydrogencarbonates (for example sodium sulphate) , potassium bicarbonate, stone anaerobic hydrogen planing, which is used in the form of an aqueous solution. In the case where r is an alkyl group, the compounds 19 and 20 are subjected to alkaline deuteration. Suitable bases are especially alkali metal alkoxides such as sodium decoxide, sodium ethoxide or potassium t-butoxide in the respective alcohols. The deuterated compounds 21 and 22 are then hydrolyzed to the respective acids 23 and 24. The hydrolysis is generally carried out in an assay medium using, for example, the same as described above for the addition reaction. In the case where R is an alkoxy group, the two solid groups are first hydrolyzed and then the resulting diacid is removed to obtain a monobasic acid 23 and 24, more preferably in the presence of a strong acid (for example, hydrochloric acid, hydrogen desert acid, nitric acid, sulfuric acid). Or strong (sodium hydroxide, potassium hydroxide) as a catalyst, using formic acid and water or 147475.doc • 62· 201043139 gaseous CO to hydrogenate 23 and 24 to obtain diacid 25. Cyclization of 25 in a polar solvent such as methanol, ethanol, isopropanol or tert-butanol under acidic conditions such as hydrochloric acid, hydrochloric acid, sulfuric acid, tribasic acid affords the cyclopentanone 10'. Process 5

As an alternative to the method described in Scheme 1, it is possible with Org. Syn. 40, 66, 1966 i J. Org. Chem. 28, 1 128, 1963 and Org. Syn. Coll., Vol. 4, 552, 1963 The method described in the above is similarly, as outlined in Scheme 6 below, by first performing a Wittig reaction on cyclopentanone 5, thereby obtaining the corresponding outer mercapto compound 41, and then subjecting it to epoxidation. The reaction was carried out to prepare ethylene oxide 6. The Wittig reaction can be carried out under standard conditions, such as the use of sulfonium triphenyl sulphate or methyl iodide scales, in alkali metal bases (such as n-butyllithium, second butyllithium or tert-butyllithium) ) exists in 147475.doc -63 - 201043139. Epoxidation can also be carried out using standard reagents such as peroxyacetic acid 'perbenzoic acid, meta-perbenzoic acid, per-phthalic acid and the like. The alkylation of $ (i.e., conversion of C=〇 to a C=CH2 group) can be achieved by using a Tebbe, s reagent ((C5H5)2TiCH2ClAl(CH3)2). Process 6

Thinning

Epoxidation

As a method of the process described in Scheme 1, you can also prepare compound 7 similarly to the method described in Scheme 7 below. After epoxidizing cyclopentanone 12 (as described in Scheme above!), the resulting epoxide 26 can be similar to [l, 2, 4l·lH, similar to the procedure described in Scheme i for (d). Oxazole reaction. The reduction of the resulting compound 27 can be carried out in the form of a standard hydrogenation in the presence of a palladium or nickel catalyst as described above for Scheme 3, or can be carried out by using a metal hydride such as sodium borohydride or lithium aluminum hydride. Cyclopentanone 12 can be prepared as described in Scheme 3 above. Process 7

I47475.doc 64- 201043139 The alternative method for the method described in the process 1 can also be as follows: Process 8 t, ^«#EP-A-0357404 .EP-A-0576834^EP-A-0648751 Compound 7 was prepared analogously to the method described. By 2 (wherein γ is a cleavage group, such as a halogen group (for example, Cl, Br, I), a serotonin, or a mesylate group) Ο 烷基 alkylation of 28 29 is obtained after deprotonation of the activated methylene group with a base in a suitable solvent. Suitable bases are, for example, alkali metal alkoxides (for example sodium methoxide, methanol unloading, sodium ethoxide, potassium ethoxide, potassium butoxide), metal hydrides (for example sodium hydride, potassium hydride) or alkali metal carbonates (for example carbonic acid) Sodium, potassium carbonate, carbonic acid planing). Suitable solvents are, for example, alcohols (e.g., methanol, ethanol, butanol), itG columns such as tetrahydrofuran, N,N-dimethylformamide or m-methylpyrrolidone. 'S alcohol (such as methanol, ethanol, propanol, isopropanol, butanol or tert-butanol, especially decyl alcohol or ethanol) in the presence of an acid such as hydrochloric acid, hydrobromic acid, sulfuric acid 'p-toluenesulfonic acid To convert to the corresponding enol ether 3〇 (wherein the square is a tetraalkyl group, especially a methyl or ethyl group), and for example, a subsequent metal reduction using a miscible metal hydride such as sodium borohydride or lithium aluminum hydride, Cyclohexenone 31 was obtained. Halogenation with bromine or iodine in the presence of an acid such as hydrobromic acid, acetic acid affords 32 wherein A and B are Br or I. Subsequent to an alkali metal alkoxide (such as sodium methoxide, sodium ethoxide, methanol or ethanol), the corresponding alcohol (ie, μ, such as Na or K; R, = for example, decyl, ethyl) Favorskii rearrangement to obtain cyclopentene 33 substituted with vinegar. For example, by peracetic acid, perbenzoic acid, m-chloroperbenzoic acid or perphthalic acid, the cyclopentene double bond is epoxidized under standard conditions to give 34, for example using a miscible metal hydride such as sodium borohydride. Or hydrogenation is reduced to diol 35 via aluminum). After converting a hydroxyl group bonded to a methylene group to a leaving group (such as a halogen group 147475.doc-65-201043139 (for example, Cl, Br, I), a toluene group or a phthalate group), and Scheme 1 The reaction of 6 described above similarly gives the resulting compound 36 (D = a cleavage group such as a halo group (e.g., Cl, Br, I), a tosylate group or a formate group) with [1, 2, 4]-1Η-triazole reaction to give compound 7. Process 8

As an alternative to the process described in Scheme 1, compound 36 can also be prepared analogously to the process described in Scheme 9 below. First, under the acidic conditions in water (such as hydrochloric acid, hydrobromic acid, acetic acid, sulfuric acid or p-toluenesulfonic acid), the ring 147475.doc -66-201043139 oxide 6 open-loop w π μ clothing is paid to 35, then as above It is converted to 36' as described in Scheme 8 or 6 is directly opened by using a suitable source of Cr, Br or hydrazine to give 36. Process 9

As an alternative to the method described in Scheme 1, compound 1A can also be prepared analogously to the method described in Scheme 1 与, as described in WO 99/18088, wherein R4 is Hj*n is 〇 (or compound) ΠΑ, where R4, h). In the presence of an acid (such as hydrochloric acid, hydrobromic acid, acetic acid, sulfuric acid or p-toluenesulfonic acid) or a base (such as _ethylamine, diisopropylethylamine, sodium carbonate or potassium carbonate) in a suitable solvent ( Such as alcohol (such as methanol, ethanol, isopropanol, tert-butanol), N-methylpyrrolidone, ether (such as ether, tetrahydroanion, dioxane, dimethoxyethane), 6 Guess, N, N-dimethylformamide or dimethyl, hard) with 6 epoxide with hydrazine; hydrazine, to give 37. It is then passed with a thiocyanate such as sodium thiocyanate, potassium thiocyanate or ammonium thiocyanate (ie, for example Na, K, NH/) in a suitable solvent (such as an alcohol (eg methanol, ethanol, iso) Propyl alcohol, tert-butanol), N-methylpyrrolidone, ether (eg diethyl ether, tetrahydrofuran, dioxane, i,2-dimethoxyethane), acetonitrile, n, n•dimethyl The reaction is carried out in decylamine, dimethylsulfoxide, toluene or xylene to convert to SemiCarbaZide 38. The semi-calendar is then converted to IA by reaction with alkane vinegar (e.g., methyl formate, ethyl formate) in a solvent. Suitable solvents are 147475.doc -67- 201043139, tert-butanol), fluorenyl-mercaptopyridine dioxane, 1,2-dimethoxy, dimethyl hydrazine, toluene or di-alcohol (eg methanol) , ethanol, isopropanol, each hydrazine (such as diethyl ether, tetrahydro sulphate, acetonitrile), acetonitrile, hydrazine, hydrazine hydrazine hydrazine toluene. Alternatively, 37 and thiocyanate can be used. Furfural is reacted in a solvent. Suitable solvents are, for example, alcohols (e.g., methanol, ethanol, isopropanol, tert-butanol), hydrazine methylpyrrolidone, ethers (e.g., diethyl ether, tetrahydrofuran, dioxane I, 2 Methoxyethane), acetonitrile, hydrazine, hydrazine-dimethylformamide, dimethyl sulfoxide toluene or xylene, followed by the presence of an alkali metal hydroxide (for example, sodium hydroxide hydroxide) and elemental sulfur The resulting triazulalidinthi〇ne 39 is oxidized to ruthenium using, for example, an aqueous solution of acid containing Feci3 (e.g., hydrochloric acid) or oxygen. In yet another alternative, 37 is made with a dialkyl ketone (e.g., propylene _) , diethyl ketone, methyl ethyl ketone) and thiocyanate (such as sodium thiocyanate, potassium thiocyanate, ammonium thiocyanate) in solvent The reaction gives triazolidine thione 4 〇. Suitable solvents are, for example, alcohols (such as methanol, ethanol, isopropanol, tert-butanol), Ν-methylpyrrolidone, ethers (such as diethyl ether, tetrahydrofuran, dioxane, n Dimethoxyethane), acetonitrile, hydrazine, hydrazine-dimercaptocarboxamide, disulfoxide, toluene or xylene. Triazolidine thione 4 〇 followed by acid (eg hydrochloric acid, hydrobromine The reaction with formic acid in the presence of acid, acetic acid, sulfuric acid, p-toluenesulfonic acid) or a metal oxide (for example, amorphous Ti〇2) is converted to hydrazine. 147475.doc •68· 201043139 Process ίο

Ο Ο as outlined in the method described in Scheme 1 and in the WO 99/1_2 scheme' can also be as follows IA and IB, where Μ is 14 and 11 is I 4 4, phlegm ΙΑ and ΙΒ,) (or compounds ΙΙΑ and ΙΙΒ 'where R' is Η). Depending on the acid (eg hydrochloric acid, hydrobromic acid, acetic acid, sulfuric acid or p-toluenesulfonic acid) or base (eg triethylamine, diiso) In the presence of propylethylamine, sodium carbonate or potassium carbonate) in a suitable solvent (such as alcohol (such as methanol, ethanol, isopropanol, tert-butanol), Ν-methylpyrrole biting, key (such as the puzzle, Oxidation of 26 with hydrazine in tetrahydroethylene, dioxin, 1,2-dimethoxyethane, acetonitrile, hydrazine, hydrazine-dimethylformamide or dimethyl sulfoxide) 147475.doc -69- 201043139 Open J coat * to 42. "Then with sulphate (such as sodium sulphate, potassium thiocyanate or thiocyanate bond (ie Μ + = for example Na+, Κ+, NIV )) in suitable solvents (such as alcohol (such as decyl alcohol, ethanol, * propanol, tert-butanol), hydrazine methyl pyrrolidone, ether (such as ether, hydrogen, methane, dioxane I, 2-methoxy) Base ethane), In a nitrile, ν, Ν-dimethylformamide, dimethyl sulfite, toluene or dimethyl strepamine, the reaction is converted into a semi-calendar 43 (a half-calorie followed by a work-and a formic acid) For example, formic acid methyl vinegar, formic acid B) is converted to IB by reaction in a solvent, and suitable solvents are, for example, alcohols (for example, methanol, ethanol, isopropanol, second butanol), N-decylpyrrolidone, ether ( For example, diethyl ether, tetrahydrofuran monooxane, hydrazine, 2-dimethoxy ethane), acetonitrile, ν, ν-dimercaptomethyl hydrazine, monomethyl sulfoxide, toluene or xylene. 42 is reacted with hydrogen thiocyanate and furfural in a solvent. Suitable solvents are, for example, alcohols (for example, decyl alcohol, ethanol, isopropanol, tert-butanol), hydrazine methylpyrrolidone, ethers (such as diethyl ether). , tetrahydrofuran, dioxane, i,2-dimethoxyethane), acetonitrile, N,N-dimercaptocarbamide, disulfoxide, toluene or xylene, followed by an alkali metal hydroxide ( Oxidation of the resulting triazole 0 thione 44 to IB using, for example, an aqueous solution of an acid containing FeCh (for example, hydrochloric acid) or oxygen in the presence of elemental sulfur, for example, sodium hydroxide or potassium hydroxide. f. In yet another alternative, 42 is combined with a dialkyl ketone (eg, acetone, diethyl ketone, methyl ethyl ketone) and a thiocyanate (eg, sodium thiocyanate, potassium thiocyanate, thiocyanate) Ammonium) is reacted in a solvent to give triazolidine sulfur _ 45. Suitable solvents are, for example, alcohols (e.g., decyl alcohol, ethanol, isopropanol, tert-butanol), N-methylpyrrolidone, ethers (e.g., diethyl ether, tetrahydrofuran). , dioxane, 1,2-dimethoxyethane), acetonitrile, N,N-dimercaptomethylamine, dimethyl sulfoxide, toluene or dioxane. Triazolidine thioindole 45 is then It is converted to IB by reaction with formic acid in the presence of an acid (for example, 147475.doc • 70·201043139 such as hydrochloric acid, hydrobromic acid, acetic acid, sulfuric acid, p-toluenesulfonic acid) or a metal oxide (for example, amorphous Ti〇2). IB can be converted to IA by hydrogenation using a palladium or nickel catalyst or by reduction with a mismatched metal hydride such as sodium borohydride or lithium aluminum hydride. Process 11

As an alternative to the method described in Scheme 11, the compound can also be prepared by vulcanizing the hydration compound 27 similarly to that described in Scheme 12 below by converting 7 to μ in Scheme i. Wherein R4gH&amp;n is the indole compound IB,) (or compound Im, wherein R4a is imprinted. 147475.doc •71- 201043139 Scheme 12

The % oxide 26 can be opened 46 under the acidic conditions of water (eg, hydrochloric acid, hydrobromic acid, acetic acid, sulfuric acid, or p-toluenesulfonic acid) as shown in Scheme 7 or Scheme 13 below, followed by 46 Compound 27 was prepared by converting it to 47 as described above for Scheme 8, or by directly opening 26 to a suitable source using cr, hydrazine or hydrazine. Subsequent reaction of 47 with the reaction of 6 described in Scheme i was carried out similarly to [1,2,4]-1H-triazole to give 27. Process 1 3

The benzyl compound 2 and the carbonyl-substituted benzene compound 11 used in the above reaction are commercially available or can be prepared by standard methods known to those skilled in the art. Compounds of the formula m (wherein hydrogen and 4 Å) can be prepared from the compounds ^ and IB' (wherein R4 = H and n = 0). 147475.doc • 72· 201043139 can be similar to the method described in de-a_1952_w by making the compound ia, wb. and the compound r4_lg (wherein R4 has the above meaning - and ^ is a leaving group, such as a functional group (eg Cl' Br]), toluene oleic acid acetonate or acetoacetate) is prepared by reacting in the presence of a base to prepare a compound of the formula IA and the formula IB (wherein n is 0 and the rule 4 is a Cl_Cl 〇 院, ^10_alkyl, C2_Ci〇, C2_c10 dentyl, c2_ClG alkynyl, C2_Cig_ fast radical, C3_Cig cycloalkyl, ring-based, phenyl, phenyl {a alkyl, the last two of which are oxime &amp; The phenyl moiety may be taken as described above, and contains 5 or 3 hetero-atoms selected from the group consisting of ganglia and 8 as a member of the ring or a "saturated, partially unsaturated or aromatic heterocyclic ring, wherein The ring may be substituted as described above. Suitable bases are, for example, alkali metal hydrides (e.g., sodium hydride, potassium hydride), alkali metal hydroxides (e.g., sodium hydroxide, potassium hydroxide), alkali metal carbonates (e.g., sodium carbonate). , potassium carbonate, barium carbonate), alkali metal alkoxide (such as methanol sodium 'methanol clock, sodium ethoxide, ethanol unloading, third Butanol unloading) or organic (iv) (for example, n-butyllithium, dibutyllithium, tert-butyllithium, and lithium diisopropylamine). The reaction is generally carried out in a suitable solvent. Suitable solvents are, for example, toluene, N- Mercaptopyrrolidone, ether (eg diethyl ether, tetrahydrofuran, dioxane, 1,2-methoxyethane), acetonitrile, N,N-dimethylguanamine or diterpene. The method described in -A-19617461 is similarly by reacting compound IA or IB with compound r5_c(=〇)_w, R5-C(;=S)-W, R5, -lsi=C:=C) or r5 '-n=c=s (wherein R5 has one of the above meanings, R5. is Ci_Ci〇alkyl or 匕-匚(7)haloalkyl and w is a good leaving group such as a halo group (eg C1, Br, I), Alkoxides (eg, methoxide, ethoxylate) or pentafluorophenoxy 147475.doc • 73- 201043139 The modification proceeds to prepare compounds of formula IA and formula IB (wherein... and R is -C(=〇) R or · C (= S) R5). For example, it is suitable to test metal hydride (such as sodium hydride, potassium hydride), alkali metal hydroxide (such as sodium hydroxide, potassium hydroxide), metal carbonate ( Such as sodium carbonate, carbonic acid unloading, carbonic acid Planing), alkali metal alkoxide (such as sodium methoxide, potassium methoxide, sodium ethoxide, potassium alkoxide, potassium butoxide) or organic lithium base (such as n-butyl lithium, second butyl, tert-butyl) Clock, ri-propyl face, octa-amine lithium). Generally, the reaction is carried out in a suitable solvent. Suitable solvents are, for example, toluene, N-methyl phase, shouting (eg, yoke, tetrahydrofuran, bismuth) , ❻ dimethoxyethane), acetonitrile, hydrazine, hydrazine-dimethylformamide or dimethyl sulphite. It can be similar to the method described in DE-A No. 20590 by the compound ία, or m, and the compound r5_s〇2_w (wherein r5 has one of the above meanings and w is a good leaving group such as a functional group (for example, a, Br, ... alkoxide (10) such as methoxide, ethoxylate or pentafluorophenoxide) is reacted in the presence of a test to prepare a compound of the formula ΙΒ and ΙΒ (where 11 is 〇 and 114 is _8 〇 #5) . Suitable for testing, for example, metal hydrides (such as sodium hydride, potassium hydride), metal oxides (such as sodium hydroxide, hydroquinone), metal carbonates (such as sodium carbonate, carbonic acid, carbonic acid), Alkali metal alkoxide (such as sodium methoxide, potassium methoxide, sodium ethoxide, potassium ethoxide, flute-pfM,);,,,,,,,,,,,,,,,,,,,,, Clock, third butyl clock, diisopropylamine clock). The reaction is carried out in a suitable solvent. Suitable solvents are, for example, methyl, N-methylpyrrolidone, ethers (e.g., diethyl ether, tetrahydrofuran, dioxane 'oxime, 2-dimethoxyethane), acetonitrile, N,N-dimethylformamide Or dimethyl hydrazine. It can be similar to the method described in DE-A-19620407 by compound 147475.doc •74- 201043139 ΙΑ or IB′ with compound CN_W (where w is a good leaving group such as a halogen group such as Cl, Br, I The reaction is carried out in the presence of a base to prepare a formula IA and a deuterated sigma (where n is 0 and R4 is _CN). Suitable bases are, for example, alkali metal hydrides (e.g., sodium hydride, potassium hydride), alkali metal hydroxides (e.g., sodium hydroxide, potassium hydroxide), metal carbonates (e.g., sodium carbonate, rhodium carbonate, cesium carbonate), bases. a metal alkoxide (such as sodium methoxide, potassium decoxide, sodium ethoxide, potassium ethoxide, potassium butoxide) or an organic lithium base (such as n-butyl lithium, second butyl ◎ lithium butyl lithium, two Lithium isopropylamine). The reaction is usually carried out in a suitable solvent. Suitable agents are, for example, toluene, N-methylpyrrolidone, ether (for example, ethylene, tetrahydrofuran, di., cautery, i,2-dimethoxyethane), B guess, N, N - dimethyl decylamine or dimethyl hydrazine. It can be similar to the method described in DE-A-196 17282 by reacting compound IA' or IB' with amine NRaRbRc (wherein Ra, r1^rC is as defined above) or with a metal salt (such as sodium hydroxide, hydrogen) Oxidation of (tetra) copper acetate) to prepare compounds of formula IA and formula IB (wherein n is oxime and rule 4 is M). 〇▼ is similar to the method described in W〇97/43269 by reacting compound IA, or IB with a halogen (especially iodine) in the presence of a base to prepare a compound of formula ia and formula, which is a group of formula m group. Suitable for testing, for example, metal hydrides (such as hydrogen hydride, potassium hydride), metal hydroxides (such as sodium hydroxide, potassium hydroxide), alkali metal carbonates (such as sodium carbonate, potassium carbonate, carbonic acid planing), alkali a metal alkoxide (such as sodium methoxide, potassium methoxide, sodium ethoxide, potassium ethoxide, potassium butoxide) or an organic lithium base (such as n-butyl lithium, first butyl lithium, second butyl lithium, diisopropylamine) lithium). The reaction is usually carried out in a suitable solvent. Suitable solvents are, for example, toluene, N-methylpyrrolidone, ether 147475.doc • 75- 201043139 (eg, test, tetrahydrogen, two chews, ^dimethoxyethane, acetonitrile, N, N-di Methylformamide or dimethyl hydrazine. The method described in WO, present and present (4) similarly prepares the formula 汨 compound 'where n is a method which can be discussed with W〇99/1 Similarly, a compound of formula μ and formula 1B wherein R4 is hydrogen (or compound IIA and hydrazine wherein R4a is hydrogen) is prepared by reacting tris-thione 39 or 44 with an oxidizing agent, optionally in the presence of a catalyst. For example, oxygen, sulfur and potassium superoxide. Especially in the case of using oxygen as the oxidizing agent, it is preferred to carry out the oxidation reaction in the presence of a catalyst. Suitable catalysts are, for example, a mixture of powdered sulfur and k〇h. The reaction is generally carried out in a suitable solvent. Suitable solvents are, for example, aliphatic hydrocarbons (e.g., pentane, hexane), cycloaliphatic hydrocarbons (e.g., cyclohexane), aromatic hydrocarbons (e.g., benzene, toluene, diphenyl), ethers (e.g., hexascale, fluorenyl). Third butyl (4) and vinegar (9) such as ethyl acetate, propyl acetate, and n-butyl acetate Vinegar) Oxidation of triazopyridine ketone 39 or 44 can also be carried out analogously to the method described in 〇〇ι/46ΐ58 using an acidic aqueous solution containing ferric chloride (FeCl3). It is generally carried out in a suitable solvent. The solvent is, for example, ethanol, ethyl acetate and a mixture of ethyl acetate and toluene. It can also be similarly used in the presence of a catalyst in the presence of a catalyst similar to the method described in WO 99/18086 or % 99/18〇88. For example, the oxidation of the thione is suitable for the catalyst. For example, the catalyst is, for example, an acid such as hydrochloric acid, sulfuric acid or p-toluenesulfonic acid; and a metal oxide such as amorphous titanium dioxide is generally reacted in a suitable solvent: suitable solvent Is a weakly polar solvent such as, for example, an alcohol such as propanol, butanol and decyl alcohol; an ester such as ethyl butyl acetate and isobutyl 147475.doc -76- 201043139; an ether such as 1,2-dimethyl Oxyethane, decyl-tert-butyl ether and methyl-tert-butyl ether; and formic acid used in excess. In combination with the above-mentioned compounds IA' and IB in which R4 is hydrazine, it is converted into a compound in which R4 is not hydrazine. Similar to 'can be prepared by reacting an NR4a group (wherein R4a is η) And a compound of the formula IIB (wherein R4a is not hydrogen). The compound I having η of 1 or 2 can be prepared by oxidizing a respective compound having a η of 0. Alternatively, the triazolyl ring can be firstly obtained from the compound 7 or 27. Deprotonation of hydrazine and subsequent reaction with sulfonium chloride r4S〇2C1 to prepare compound I with η of 2. Compound I of 11 can be derived from compound 7 or 27 by first deprotonating the triazolyl ring and then with sulfuric acid. Chlorine or a sulfuric acid ester of the formula R4〇S〇2Cl is reacted to prepare 'where R4 is selected from hydrogen, d-Cio alkyl, (: "(:! 〇 烧, c2-c10 alkenyl, c2-c1) () a dilute base, a C2_ClQ block group, a c2_CiG haloalkynyl group, a c3_Ci〇cycloalkyl group, &lt;:3_(:10 halocycloalkyl, phenyl, phenyl-Ci_c4 alkyl, the last two of which are mentioned The phenyl moiety in the group may be substituted as described above, and a 5- or 6-membered saturated, fluorene-saturated or aromatic heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, fluorene and 8. Wherein the heterocyclic ring can be substituted as described above. If individual compounds are not prepared by the above routes, they may be prepared by derivatization of other compounds I and II or by conventional modifications of the synthetic route. The reaction mixture is treated, for example, by mixing with water, isolating the phases and, if appropriate, purifying the crude product by chromatography (e.g., alumina or silica gel chromatography). - Some intermediates and final products may be obtained in the form of a colorless or light brown viscous oil which can be released or purified from volatile components under reduced pressure and at moderately elevated temperatures. If the intermediate and final product are obtained in solid form, then 147475.doc-77-201043139 can be purified by recrystallization or leaching. Another aspect of the invention pertains to a compound of formula iv,

N-N

L2 Η (IV) wherein R1, R2, R3, L1 2 3 L and [the following compounds having one of the general meanings or in particular the preferred meanings given above for the compound, wherein 'CF3, and rrrr are double Key; "methoxy or R1 and R2 are both CH3, R3, l2, L3 and l4a - decyloxy or CF3, and rrrr is a double bond; ',, 虱, L! is fluorine, bromine, R1, R2 , R3, L1, L\L4 are hydrogen, L bond, -, CF3, and the second T is a single preferred compound IV is a compound] VA,

(IVA) 147475.doc •78· 201043139 where R1, R2, R3, L1, L·2, L3 and L4 have the general meaning — or specifically the preferred meaning given above for the compound —. Except where R, R2, R3, L!, L3 &amp; L4 are hydrogen L2 is CF3 Compound IV and IVA are aspects of the preparation of valuable intermediates in compounds 1 and 11 (see compounds 7 and 27), but another Aspects also showed significant fungicidal activity. Particularly preferred compounds are compounds of the formula 1 ¥1 to 1 ¥8, wherein the combination of y, R, L, L, L3 and L4 corresponds in each case to one of the above Tables a. 〇

Another aspect of the invention pertains to a compound of formula V,

201043139 wherein R, R, R3, L1, L2, l3 and L4 have one of the general meanings or specifically one of the preferred meanings given above for the compound; except for the following compounds, wherein R1 'R2 'R3 ' 12 λ τ 3 κ τ 4 * ^ , , and L are 虱 'l is fluorine or CF3, and τττΓ is a double bond; ..., ^ and ^ are hydrogen '^ and are considered to be fluorine' and two are single bonds; Except for the following compounds, wherein RR, R, L, L3 and L4 are hydrogen, L1 is desert or methoxy, and - is a double bond; R and R2 are both CH3 'R3, l2, P and L4 are hydrogen, Ll is fluorine, methoxy or CF3' and diτ is a double bond; R1, R2, R3, L1, L3 and L4 are hydrogen, L2 is CF3, and = bond 0 is bromine, which is a single preferred compound V is compound VA ,

', RR, R and L4 have the general meaning - or characteristic δ above one of the preferred meanings given for the compound and · · except for the following compounds 'its ~ ^ ^ ^ is hydrogen ... 丨 and L4 is fluorine. 147475.doc 80· 201043139 Compounds V and VA are valuable intermediates in the preparation of compounds I and II (see compounds 6 and 26). Another aspect of the invention pertains to a compound of formula VI,

CH R3 L

Ο wherein R1, R2, R3, L1, L2, L3 and L4 have one of the general meanings or specifically one of the preferred meanings given above for the compound 丨 and 丨; except for the following compounds, wherein r2, r3 , [2, L3 and L4 are hydrogen, L1 is bromine, and ΤΓΓ7 is a single bond; also preferably 'except for the following compounds, wherein R, R2, R3, L2, L3 and L4 are hydrogen' L1 is fluorine, bromine, Alkoxy or CF3, and - is a double bond; 3, , L2,

R1 and R2 are both CH

Preferred compound vi is compound VIA, L3 and L4 are hydrogen, l1 is fluorine, bromine, L is CF3, and Τ7ΓΓ is a single

147475.doc -81 - 201043139 wherein R1, R2, R3, L1, L2, L3 and L4 have one of the general meanings or, in particular, the preferred meanings given above for the compounds I and hydrazine. Wherein R1, R2, R3, L2. And l4, and L1 is bromine. Milk Compounds VI and VIA are the preparation of compounds 1 and 1] (the valuable intermediates thereof (see compound 41). Another aspect of the invention pertains to compounds of formula VII,

Wherein, "'., ~^ have one of the general meanings or specifically one of the preferred meanings given above for compounds 1 and 11, and R14 is Η or C(0) 〇 R15, wherein R15 is selected From hydrogen, Cl-Cl0 ndyl, Cl_c "homogeneous, C3_Ci 〇 cycloalkyl, cycloalkyl, phenyl, phenyl-Ci_C4 alkyl, wherein the phenyl moiety of the last two mentioned groups may have 2, 3, 4 or 5 substituents 118, and a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring containing 2 or 3 heteroatoms selected from N, fluorene and S. Wherein the heteropoly can have 2 or 3 substitutions #, wherein R8 is as defined above; except for the following compounds, wherein R:, R2, R3, Rl4, L2, L3mwL, CF3n ..., ..., ..., plus It is hydrogen 147475.doc 201043139 or IL; R1, R2, R3, L and 14 are hydrogen, P and l3 are tributyl, and r14 is hydrogen or cooch3. Compound VII is a valuable intermediate for the preparation of the compound {and oxime (see Compound 4). ^ Another aspect of the invention pertains to a compound of formula VIII,

L2 (VIII) Η where R1, R3, L1, L2, L3AL4 have the general meaning - or specifically the above for the compound 丨 and 丨! One of the preferred meanings given, and is as defined above; except for the following compounds, wherein J.L24CF3^ f is fluorine; R1, R3, L1 and 1 are hydrogen, L2AL3 is a third butyl group, and r14 is Ammonia or COOCH3 ο Compound ν is a valuable intermediate in the preparation of compounds (see Compound 3). Another aspect of the invention pertains to a compound of formula IX, 147475.doc-83· (IX) 201043139 M R3 L1

Wherein one of the meanings; /, there is a general meaning of the first one is specified above for compounds 1 and 11 except for the following compounds, including CF3 or bromine, and 111, 112, 113, 1 ^, 1^^3 and 1/ are hydrogen, 1; ΤΤΤΓ is a single bond; R1, R2, R3, R14, L1, L3 and ι/Α gas τ2 are produced as 虱' L2 is CF3, decyloxy or fluorine And diterpene is a single bond; is a third butyl group, R14 is hydrogen, R1, R2, R3, L1 and L4 are hydrogen, L2 and L: or COOCH3, and two are single bonds; preferably, the following compounds are excluded ,among them

Ri, R2, R3, L2, CF3, and are double bonds; L and L are hydrogen, Li is fluorine, bromine, decyloxy or R and R are both CH3, R3, L2, L3τ 4 &amp; L and L Is argon, L! is fluorine, bromine, methoxy or CF3' and ττττ is a double bond; RRR, L, L3 and L4 are hydrogen 'L2 is Cf3, and two are single-bonded IX for preparing compound ΙΑΠ Valuable intermediates (see compounds 5 and 12). Of course, the above-mentioned limitations of Compound I and hydrazine (ie, L1, U, L3, and L to y are not rats) for Compounds IV, iva, V, VA, VI, 147475.doc-84-201043139 VIA, VII , VIII and IX are also effective. The invention further relates to an agricultural composition comprising at least one compound of formula I, II and/or IV as defined above, or an agriculturally acceptable salt thereof, and a liquid or solid carrier. Suitable carriers and auxiliaries and other active compounds which may also be included in the compositions of the invention are defined below. The compounds I and II and IV and compositions of the invention are each suitable for use as a fungicide. It is resistant to the outstanding effects of a wide range of phytopathogenic fungi.

❹ 'These plant pathogenic fungi include soil-borne fungi, especially from Plasmodiophoromycetes, Peron 〇Sp0romycetes (synonym 〇〇inycetes), and chytrids (Chytridiomycetes), ZygomyCetes, ASCOmycetes, Basidi〇mycetes, and DeUteromycetes (synonymous fungi (Fungi .... Some have systemic utility and It can be used as a foliar fungicide, seed dressing fungicide and soil killing in crop protection. In addition, it is suitable for controlling harmful fungi which are especially found in the roots of wood or plants. And the composition is in the control of various cuts (4) (such as cereals, such as wheat, rye, barley,

Rice; beet 'eg beet or fodder beet; fruit, such as pear fruit swallow = 2 and non-nuclear, such as apple, t, plum, peach, almond X raspberry, raspberry, blackberry or gooseberry; legume, _ : Zhuo, 苜 or soy; oil plants, such as oil peas, coconut, cocoa beans, marijuana, oil labels, groundnuts or large =, / 曰 plants, such as + claws A seven twisted ugly, cucurbitaceae such as Pumpkin, melon or melon; fiber phytochemical, 147475.doc -85- 201043139 匕, marijuana or jute' citrus fruits, such as lamps, lemons, grapefruit vegetables, such as vegetables, stalks, Dongsong, Cabbage, carrot, gourd, potato, gourd or pepper; laurel plant, such as avocado, cinnamon or camphor: energy and raw plant, such as corn, soybean, canola, sugar cane or oil palm; corn; Nuts; café; apple leaves; bananas; vines (fresh grapes (10) le gqing e) and grape juices: (2), hops, grasses, 'natural rubber plants or ornamental plants and forest plants' such as flower shrubs, Broadleaf or evergreen tree It is especially important in many phytopathogenic fungi such as conifers and plant propagation materials such as seeds and crop materials of such plants. The compound nhv and the composition thereof are preferably used for controlling a plurality of fungi on the field crops, such as potatoes, beets, tobacco: wheat, rye, barley, oats, rice, corn, cotton, soybeans, : vegetables, legumes, hollyhocks, coffee or ginseng; fruit; vines, ornamental plants, or vegetables, such as cucumbers, guava, beans or pumpkins. It should be understood that the term "plant propagation material" means all reproductive parts (such as seeds) and vegetative plant materials such as cuttings and tubers (e.g., potatoes) that can be used to propagate plants. It includes seeds, roots, fruits, lumps, bulbs, rhizomes, shoots, buds and other plant parts, including Xuan Miao: young, which is transplanted after germination or after emergence. These seedlings can also be protected prior to transplantation by whole or partial treatment by crushing or pouring. Treatment of plant propagation material with the compositions of Compounds 11 and 1 is preferably used to control mites (such as wheat, rye, barley, and oats); and numerous fungi on rice, corn, cotton, and soybeans. 147475.doc • 86 · 201043139 The term “cultivated plants” is understood to include plants that have been modified by breeding, mutation induction or genetic engineering, including (but not limited to) biotech agricultural products that are commercially available or under development (see http: //www.bio.org/speeches/pubs/er/agri_products.asp) Genetically engineered plants have been genetically modified by using recombinant DNA techniques so that they cannot be crossed, mutated or naturally in nature. A plant that is easily obtained by recombination. One or more genes have typically been integrated into the genetic material of a genetically engineered plant to modify certain characteristics of the plant. Such genetic engineering also includes, but is not limited to, targeted post-translational modifications of proteins, oligopeptides or polypeptides, such as prenylation, acetalization or farnesylation, by glycosylation or polymer addition ( Farnesylated) part or PEG moiety. As a result of conventional methods of breeding or genetic engineering, plants that have been engineered by breeding, mutation induction or genetic engineering, for example, are tolerant to the application of a particular class of herbicides such as hydroxyphenylpyruvate Oxygenase (HPPD) inhibitor; acetate lactate synthase (ALS) inhibitor, such as sulfonium urea (see, for example, US 6,222,100, WO 01/82685, WO 00/26390, WO 97/41218, WO 98/02526, WO 98/02527 'WO 04/106529, WO 05/20673, WO 03/14357, WO 03/13225, WO 03/143 56, WO 04/16073) or imidazolinones (for example see US 6,222,100 'WO 01/82685, WO 00/026390, WO 97/41218, WO 98/002526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/014357, WO 03/13225, WO 03/14356, WO 04/16073) Enolpyruvylshikimate-3-phosphate synthase (EPSPS) 147475.doc -87 - 201043139 Formulations, such as glyphosate (see, for example, WO 92/00377); An amine amine synthase (GS) inhibitor, such as glufosinate (see, for example, EP-A 242 236, EP-A 242 246) Or oxynil herbicide (see, for example, US 5,559,024). A number of cultivated plants have been subjected to herbicides by conventional methods of breeding (mutation induced), for example, Clearfield® summer rapeseed (Canola, BASF SE, Germany) and scented lincolone, such as 曱 σ σ 于(imazamox). Genetic engineering methods have been used to make cultivated plants such as soybean, cotton, corn, sugar beet and canola tolerant to herbicides such as glyphosate and glufosinate, some of which are available under the trade name RoundupReady® (glyphosate versus type). Monsanto, USA) and LibertyLink® (Glufosinate, Bayer CropScience, Germany). Also encompassed is the ability to synthesize one or more insecticidal proteins by using recombinant DNA techniques, in particular from the genus Genus, especially from Bacillus thuringiensis, such as δ- Toxins such as CrylA(b), CrylA(c), CrylF, CryIF(a2), CryIIA(b), CrylllA, CrylllB(bl) or Cry9c; vegetative insecticidal proteins (VIP), such as VIP1, VIP2, VIP3 or VIP3A; an insecticidal protein of a bacterium that colonizes nematodes, such as the genus Bacillus (spor.) or the genus X. elegans spp.); a toxin produced by an animal, such as moth toxin, insect toxin, wasptoxin or other insect-specific Sexual neurotoxin; a toxin produced by a fungus, such as streptomyces toxin, plant lectin, such as cowpea or barley agglutinin; agglutinin; protease inhibition 147475.doc -88- 201043139 agent, such as pancreas Protease inhibitor, serine protease inhibitor, patatin, cystatin or papain inhibitor; ribosome deactivated protein (RIP), such as ricin, jade蜀黍-RIP, abrin, abuffin, saporin or bryodin; steroid metabolism enzymes such as 3-hydroxysteroid oxidase, quercetin-IDP - Glycosyl-transferase, cholesterol oxidase, ecdysone inhibitor or HMG-CoA reductase; ion channel blockers, such as sodium or calcium channel blockers; juvenile hormone esterase; diuretic hormone receptor ( The heterologous strain also writes the helicokinin receptor; stilben synthase, bibenzyl synthase, chitinase or glucanase. In the context of the present invention, it should also be clear that such insecticidal proteins or toxins are pretoxins, hybrid proteins, truncated or otherwise modified proteins. Hybrid proteins are characterized by a new combination of protein domains (see, for example, WO 02/015701). Such toxins or the ability to synthesize such toxins are disclosed, for example, in EP-A 374 753, WO 93/007278 'WO 95/34656, EP-A 427 529, EP-A 451 878, WO 03/18810 and WO 03/52073. Other examples of genetically engineered plants. Methods of producing such genetically engineered plants are generally known to those skilled in the art and are described, for example, in the above publication. Such insecticidal proteins contained in genetically engineered plants cause plants producing such proteins to have harmful pests to all taxa from arthropods, especially to beetles (Coeloptera), two wings Insects (Diptera) and moths (Lepidoptera) and the susceptibility to nematodes (Nematoda). Genetically engineered plants capable of synthesizing one or more kelins 147475.doc -89- 201043139 worm proteins are described, for example, in the above publication, and some of them are commercially available, such as YieldGard® (a corn cultivar producing CrylAb toxin), YieldGard® Plus (a corn cultivar producing Cryl Ab and Cry3Bbl toxins), Starlink® (a corn cultivar producing Cry9c toxin), Herculex® RW (producing Cry34Abl, Cry35Abl and enzymatic phosphonium-N-acetyltransferase [ Phosphinothricin-N-Acetyltransferase, PAT] maize cultivar); NuCOTN® 33B (cotton cultivar producing CrylAc toxin), Bollgard® 1 (cotton cultivar producing CrylAc toxin), Bollgard® 11 (production of Cry 1 Ac and Cry2Ab2) Cotton cultivar of toxin); VIPCOT® (cotton cultivar producing VIP toxin); NewLeaf® (potato cultivar producing Cry3 A toxin); Bt-Xtra®, NatureGard®, KnockOut®, BiteGard®, Protecta®, Btll (eg Agrisure® CB) and Btl76 from Syngenta Seeds SAS, France (corn cultivar producing CrylAb toxin and PAT enzyme) MIR604 from Syngenta Seeds SAS, France (corn cultivar producing modified Cry3 A toxin, see WO 03/018810), MON 863 from Monsanto Europe SA, Belgium (corn cultivar producing Cry3Bbl toxin), from Monsanto Europe SA, Belgium IPC 53 1 (cotton cultivar producing modified Cry 1 Ac toxin) and 1507 from Pioneer Overseas Corporation, Belgium (corn cultivar producing CrylF toxin and PAT enzyme). Furthermore, plants which are capable of synthesizing one or more proteins by using recombinant DNA techniques to enhance the resistance or tolerance of their plants to bacterial, viral or fungal pathogens are also encompassed. Examples of such proteins are the so-called "pathogenesis phase 147475.doc -90-201043139 related proteins" (PR proteins, see for example EP-A 392 225), plant disease resistance genes (for example, performance derived from Mexican wild potato late Potato cultivar of Phytophthora infestans against the resistance gene of Phytophthora sojae) or Τ4 lysozyme (for example, capable of synthesizing such strong against bacteria (such as Aphi/vora) Potato cultivar of resistant protein). Methods of producing such genetically engineered plants are generally known to those skilled in the art and are described, for example, in the above publication. In addition, it is also possible to synthesize one or more proteins by using recombinant DNA technology to increase productivity (eg, biomass yield, grain yield, starch content, oil content or protein content), to drought, salinity or other growth limiting environments. Tolerance of factors or plants for the pests of their plants and the fungi of fungal, bacterial or viral pathogens. In addition, it also encompasses plants which contain varying amounts of inclusions or novel inclusions, particularly for improving human or animal nutrition, by the use of recombinant DNA techniques, for example to produce healthy long-chain omega-3 fatty acids or unsaturated omega-9 fatty acids. Oil crops (eg Nexera® canola, DOW Agro Sciences, Canada). In addition, plants that contain varying amounts of inclusions or novel inclusions, particularly by increasing the yield of the raw materials, such as potatoes that produce increased amounts of amylopectin (eg, ΑιηΠ or a® potato, BASF SE) are also encompassed by the use of recombinant DNA technology. , Germany). Compounds I, II and IV and their compositions are especially suitable for controlling the following plant diseases, ornamental plants, vegetables (such as Candida albicans (丄Cfl/7山·ί/α)) and Xiang Cai 147475.doc-91 - 201043139 (eg, white rust sPP.) (white rust) on white rust fungus (丄ir&lt;3go;?ogo„b); vegetables, rapeseed (aspergillus oryzae) Cyclosporin (heart, beet (A ie (10) u)), fruit, rice, soybean, potato (such as Solanum lycopersicata (丄 or 链, a / ί ί 儿 儿), tomato (eg, Solanum solani or Intersprayed spores) and Alternaria (j/ier (10) η·α spp) on wheat (Alternaria alternata); sugar beet and snails on vegetables (1) (10) (10) hitting SPP·), the genus Sporococcus sp. on the genus and vegetables, such as wheat husks (baby anthracnose) on wheat and barley snail (丄/zorc/ez·) on barley,脐 转 ) 及 及 及 及 及 及 及 及 及 及 及 及 及 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有 有Umbilical umbilical cord spore Mountain 〇) and northern leaf blight (Cornus umbellatus) (such as, for example, the spot disease on cereals (wheat root rot 平 〇 〇 〇 〇 b b b ) ) ) ))) and such as rice and turf Helminthosporium variabilis; wheat powdery mildew (valley wwerz.a grawz.m) on cereals (such as wheat or barley) (formerly known as: buckwheat powder (£WZ&gt;/Ze ^(10)&amp;&amp;)) (powdery mildew); fruits and berries (such as strawberries), vegetables (such as lettuce, carrots, celery and cabbage), rapeseed, flowers, vine forest plants and wheat worms (Boiryi/s ckerea) (sexual t Botrytis cinerea (Boir less οίζϋ /wcAre/za/ia): gray mold); Phytophthora sinensis (Wan huiia / aciwcae) (Frost disease); broadleaf tree and $, 彔The genus of the fungus synonym (ph/osiowa) in the tree (rot or arboreal), such as the eucalyptus fungus on the eucalyptus (C. Dutch elm disease); For example, ash 147475.doc •92· 201043139 leaf spot. Corn leaf spot (c·(9), rice, sugar beet (eg beet brown spot disease (c., sugar cane, vegetables) , coffee, soybeans (such as C. sphaeroides (c. μ) or K. sphaeroides (Chmc/^·)) and the genus Cercoworaf Spp. (species of spotted pathogens) Add (for example, tomato leaf mold fungus (C.: leaf mold) and genus Phytophthora (C/ai/owor/ww spp.) on cereals, such as Phytophthora infestans on wheat (C_ black ear ( Biack ear)); ryegrass 〇 (.WC^ qing) (ergot) on the mites; corn (C. (10) fine), mites (such as Helminthosporium (Cm. v(10)), asexual: wheat root rot flat umbilical snail) and rice (eg uterus genus), asexual type: Helicobacter pylori (10) on C. cerevisiae (CW/^'oh/ Like) (asexual type: Helminthosporium umbellatus &&gt;0/π)) genus (leaf leaf spot); cotton (for example, cotton thorn spore (c. cultivar)), Maize (eg, Anthracnose stalk rot), non-nuclear fruit, potato mash (eg c. COCCOi 5^: black spot), beans (eg beans) Prickly ash (C. (5) heart (6) (10) please)) Soybean (eg, sphaeroides or sphaeroides) (C. sphaeroides) (sexual type: anthrax (G/〇were/(4)) genus (anthrax); genus C〇ri/c~m spp.), for example, C. wwHi (external sheath blight); P. sphaeroides on soybeans and ornamental plants _ this-) Disease); Cyclospora genus (9) (1) · spp ·), such as the genus Phytophthora capsici (C· 〇 / gflgz • (10) w); fruit trees, vines (such as Liriodendron (c. /ζ&gt;ζ·Μπ〇, sexual 147475.doc -93- 201043139 type: erythropoietin (iVeo«ecir/a: Black Foot Disease) and ornamental plants Helicobacter genus (Qy/k OCfl/po „ spp.) (eg if the tree ulcer or young vine declines, there is a genus: C. striata spp.) or the new genus Phytophthora (jVeonecirifl spp·) ); Demycophagus (Demaio/?/zora necairix) on soybean (sex type: Phytophthora (/?οπ//-·ύί)) (root and stem rot); Phytophthora spp. ), for example, the big black spot disease (Ζ), the falling off); jade Rice, cereals (such as barley (such as barley bacillus, net plaque), and wheat (such as D. cerevisiae (Drepen Mountain): brown spot)), Helminthosporium umbellata on rice and turf (synonymous spirospores 'sexual type: genus genus (Pyrenop/zora)) genus; vines on the vines (five Mo dheaw) (top blight, dry blight) Bacteria (F〇r»n'n&gt;〇Wa (synonym: Pseudomonas sinensis (/ϊ/2β//ζ•(10)$, Mediterranean porphyrit (jp. 咖士以厂训~), thick spores visible & 溘 (Phaeomoniella formerly known as thick bottle sign (P / zaeoacremom 'wm c / z / awj / c / osporz ^)), parasitic bottle bacteria {Phaeoacremonium and / or platyces genus (such as outside - / merk 0 heart Caffe); renju (Pear sputum bacillus (5. nectar 0), non-nuclear fruit (Raspberry sclerotia (Wan: charcoal disease) and vine (black acne cysts) ): anthracnose) on the genus Cysticer (Spiritual SPP.) 'Indica sphaeroides orjvzae' (leaf smut); Black genus on the wheat (five p/c〇ccwm spp) (black mold); beet (sweet Powdery mildew (5·^&amp;e)), vegetables (such as pea powdery mildew (£ p(5)))), such as Cucurbitaceae (eg, C. sphaeroides), 147475.doc -94- 201043139 Brassica napus, Brassica napus (for example, Rhizoctonia solani (5. Phytophthora (£r&gt;^z&gt;/ze spp.) (powder disease); Curvularia on fruit trees, vines and ornamental trees (5 /α?α) (Grape rot or top blight, asexual type: Lata pseudocyst / αία), synonym of Libertdla blepharis); Exos〇hi on corn 〖um) (synonym for Helminthosporium) genus (such as turcicum); Fusarium oxysporum (FMwri) on various plants (sex type: GiMere//a) Genus (wild wilt, root or stem rot), such as Fusarium graminearum (F. gra/m > 2ear«m) or yellow Fusarium (factory CM/worMm) on roots (eg wheat or barley) Rotten, spotted or head withered), Fusarium oxysporum on tomato (P., Fusarium solani (F s〇/am·) on soybean and Fusarium oxysporum on corn (F. veriz'e// // 〇WeiS); cereals (such as wheat or barley) and corn on the top of the sac with halogen (take-all); cereals (such as Gibberella serrata (G. "poster)) and rice (for example) G. /WA: wroi: Phytophthora spp.); vines, pome fruit and other plants on the small clusters (C? /omere//a and cotton anthracis (g·gossxpii) on cotton, Grainsajning complex on rice; Staphylococcus aureus on vine (1) (black rot); Rosaceae and胳 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上 上Type: Helminthosporium); 镊 囷 s spp.), such as coffee on the glutinous 跪 录 ( ( playing vaiiairzx) (coffee leaf rust); vines on the plant brown spot pathogen 147475.doc • 95- 201043139 (/ 显娜咖咖ra) (synonym grape branching sputum 雠 雠; soy and cotton vegetables. Coccidioides (she (10) # 二 -) (synonym Bean globulin (house w (four)) (root and stem Rotten); #类 (for example, wheat or barley) on the snow emblem suspected bacteria (10) (four) and coffee (four) mva / e) (synonym „ 司 腐 腐 腐 腐 (心.,·___)) (Pink snow mold (pmk snow M〇ld)); powdery mildew on soybeans (minus (four) coffee" (four) heart / / like " powdery mildew"; brown rot fungus (from (10) out (1) 4 spp), such as stone fruit and other Rosaceae plants Brown fruit rot fungus (M, fruit plexus spores (M·State (3) (4) and brown rot fungus (M flower and blight, brown rot); sputum, banana, non-nuclear and ground fungus Genus spp.), such as the grass root knot nematode (m gramk/C0/a) on wheat (asexual type · wheat sphaeroides (&amp;pi〇ria ir^c〇, genus genus Sepia) Blotch)) or Filipino globosa on bananas (M / (/like (4) (biack sigatoka disease); cabbage (such as Brassica oleracea) (where 6rimiCaeh, rapeseed (such as parasitic downy mildew ( p. 'Onions (eg, onion downy mildew (household, in grass (tobacco downy mildew (where iahci«a)) and soy (such as soybean downy mildew (corpse maws/zwrica)) on the downy mildew (per〇„〇 ^p Ra Spp ) (downy mildew); Phakopsora pachyrhizi anti-3~ squamous squam (j&gt;. (Dalian rust); for example, vines (eg lemon dry blight (household. irac) /ze/p/n./a) and the genus Bacillus algae (household plus raiSp0ra)) and soybeans (such as the bean stem brown rot fungus (household, call the stem rot) on the genus i%.a/〇_〇ra spp.) 'Brassica oleifera black on the rapeseed and cabbage//.«gam) (root and stem rot) and sugar beet on the beet (corpse 6eiae) (root rot, Leaf spot and cockroach 147475.doc -96· 201043139 Inverted disease; geranium, vine (eg Phytophthora platensis (8 vzYz, co/a): leaf and leaf spot) and soybean (eg stem rot: kidney bean) The epidemic emblem has a sexual type: P. sylvestris (P/zomo/wb spp.) on soybean black spot disease (D 〇 〇 / ze ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ( ( ( ( Disease); various plants 'such as pepper and cucurbitaceae plants (such as Phytophthora capsici (household, soybean (such as Phytophthora sinensis (hu. wegawerwa) 'synonym Phytophthora sojae (eight)), horse yam and tomato (for example) To Phytophthora (P.: late blight) and broad-leaved trees (such as Phytophthora ssp. var. var. var. var. var. var. var. var. var. var. var. var. var.) (P/^io/?/2i/zora spp.) Root, leaf, fruit and stem rot); Plasmodiophora brassicae (Tumor disease), of the Brassica, Brassica napus and other plants, P/izsmopara spp. ), for example, Phytophthora platensis on vines (K. Wiico/a) (vine vine downy mildew) and sunflower bacillus on sunflower (P.; Rosaceae, hops, pears and non-nuclear) Poi/oi/7/merii spp. (powdery mildew), such as apple powdery mildew on apples (P. /ewcoiric/m); for example, alfalfa (such as barley and wheat) Polymyxa (P. gra/w/m··?)) and polysaccharides (Po/ywyxa spp.) on sugar beet (Polygonum (Z&gt;eioe)) and spread from it Viral disease; base rot fungus on cereals (eg wheat or barley) (·f^eMi/ocercoworeZ/ci /lerpoiric/io^fes) (eye point, sexual type: blast fungus (Γαρα/α; various Fake cream on plants Mildew mildew] 'For example, P. cwZjenhs on Cucurbitaceae or Pseudomonas sinensis on P. chinensis (P. Zzwwz 7z·); P. variabilis on vine plant 147475. Doc -97- 201043139 irac/2ezp/n/a) (red flre disease or Roche disease (r〇tbrenner,), anamorphic. Phytophthora (P/n'a/op/i〇ra) )); rust genus sPP.) (money disease) on various plants, such as cereals (such as wheat, barley or rye) and Lu Xun (such as genus Puccinia (/&gt;. Magic)) Brown rust (p (10)) (brown rust or leaf rust), stalk rust (p sand (strip rust or yellow rust), barley rust (corpse (dwarf rust), rust rust (household) · stem rust or black rust) or leaf rust (p (brown rust or leaf rust) · ' wheat sclerotium

Wk卬(10)仏) (asexual type: umbilical cord blood snail) (brown spot disease) or nucleus on the barley (ρ·(10) called (net spot disease); Pythium genus (/v-kspp), For example, rice blast fungus (/J 〇〇; zae) on rice (sex type: rice blast fungus (from sigh) 叩〇Γί/2β to (6) illusion, rice fever) and blast fungus on turf and cereal ( P. qing); turf, n meters, wheat, cotton, rapeseed, six ugly beets, vegetables and various other plants on the genus Pythium (or / Π spp.) (such as the disease) (such as the ultimate Pythium (household m) or Pythium pyogenes (P. aphamderniaf)); genus sphaeroides (small (four) hawthorn spp. W column such as barley on the gelatin sigma column (4) Leaf spot, physiological leaf spot) and sugar beet on beet are separated by ^ ^ ϋ also); 2 rice potato, turf, corn, rape, horse bell, beet, vegetables and various other plants on the genus Rhizoctonia J For example, Rhizoctonia solani (Brother's /im/) (root and stem rot), Rhizoctonia solani (Sheath wilt) on rice or Rhizoctonia cerealum on wheat or barley (and (10); ^) (silk core Rhizoctonia wilt (RhiZ〇Ct〇nia spring blight)); Rhizopus oryzae per carrot, cabbage, vine and tomato 147475.doc -98- 201043139 {Rhizopus st〇lonifer from black mold, 氡蔵Disease y, ginseng, medlar, ginseng, black, wheat barley algae (and (scald)), onion on the rice stalk (and spleen spores (51 · (9) waiww) ( Sheath rot); Sclerotinia sp. OSc/eroikM spp·) on vegetables and field crops (stalk rot or white mold), such as rapeseed, hollyhock (eg, nucleus nucleus (iSWeroi/ηία · 5£; /βΓ〇ί!'〇ΓΜ»2)) and soybeans (eg, sclerotium (51. ro//Wi) or Sclerotinia sclerotiorum); various plants on the genus Septoria spp.), such as soybeans & glebes (brown spots), wheat husks on wheat (^. iriiicz') (shell stalk disease) and sclerotium on cereals (S. «οί/ Orww) (synonym sphaeroides (and agowwpora «ocforwm)) (Stagonospora blotch); grape powdery mildew on vine (t/«cz'«M/a «ecaior ) "Flycacum, asexual type: grape powder spore ((%/iww iwcferz)); corn (such as corn leaf spot (*S. iMrdcww), synonymous with I. cerevisiae iwrc/ Cww)) and the genus of the genus (Seiospaer/a spp.) (leaf blight); corn (eg, smut (*S·re out απα): smut (A: erneZ) Smwi)), sorghum and sugarcane on the genus Sphaerotheca (S/7/zace/oi/zeca spp.) (smut); the scorpion monofilament shell on the cucurbitaceae (&lt;S/? /zaer£?i/2eca/wngf«ea) (powder disease); potato meal on the potato (5^o«gO«sporc3! sMierrawea) (Powder disease) and the virus transmitted thereby Sexually transmitted diseases; the genus Sporotrichum spp.) on cereals, such as the genus Astragalus membranaceus (51· «Οί/orww) (Saccharomyces cerevisiae plaque, sexual type: wheat Ascomycetes (iepiojp/mer/a nodorum) [ 13⁄4 ^ =3⁄4 /J&gt; ^ H ^ g (Phaeosphaeria nodorum)]; 147475.doc -99- 201043139 Potato disease on the potato (Wohcwm) (potato cancer) ; rap/irha spp., such as peach Outer sclerotia (Γ· a?e/ormi^) (curved leaf disease) and Lee sclerotia on the plum (Guang prw«z·) (Li bag disease); tobacco, pome fruit, vegetables, soybeans and TTnWaWopWi spp. (black root rot) on cotton, such as Pythium fulvum (τ\ Zjo^co/α) (synonym string beaded emblem (C/ia/ara; film black powder on cereals) Genus (77//eii'G spp.) (common bunt or stinking smut), such as wheat smut on wheat (plant (synonym wheat net 腥 black spike) Pathogens (r· Car/ej·), wheat smut (wheat bunt) and dwarf steadily (J. ccmiroversa) (dwarf bunt); barley or wheat Wheat snow rot brown sclerotia (7&gt;p/2M/a z_«car„aM) (grey snow mold); genus genus (t/r〇Cp along spp.), such as rye Ryegrass smut (t/· (stem smut); Phytophthora ssp. (~(10) SPP·) on vegetables (recorded), ehai 荨 vegetables such as beans (eg, peas ( y· 叩山·, the synonym of Phytophthora sojae (ί/.such as _〇/(1) and beets (such as sweet-type spore rust t/. ^仏)); cereals (such as barley powdery mildew (C / · (10) heart) and oat powder black powder (r, corn (such as maize black powder fungus (t /. m叮 mountain: corn black ear Disease) and the genus Phytophthora (CAm/a spp·) on the sugar cane (san smut); apple (such as the black bacterium of the apple (plant small and the genus of the genus R. spp) Diseases and various plants (such as fruits and ornamental plants, vines, non-seeds, vegetables and field crops) on the genus Verticillium sp.) (7) wilting), such as strawberries, canola, potatoes and tomatoes. Kaohan 隹 炙 炙 炙 炙 炙 147 147 147 147 147475.doc 201043139 dahliae). Compounds I, II and IV and combinations thereof are also suitable for controlling harmful fungi in protected storage products or in harvested and protective materials, respectively. The term "protective material" is understood to mean the protection of industrial and non-living materials such as adhesives, glues, wood, paper and cardboard, textiles, leather, paint dispersions, plastics, cooling lubricants, fibres and fabrics to prevent harmful microorganisms. Infection and destruction (such as fungi and bacteria). In the protection of wood and other materials, the following harmful fungi are particularly noteworthy: Ascomycetes (such as the genus Aspergillus sp.), the genus of the fungus (spp.), the dwarf stalk (dwreoftasWM/w, {Sclerophoma spp.), Chaetomium (C/meio z'ww spp.), Humicola (T/wmz'co/α spp.), Peerz'e //a spp.), TWc/zwrws spp.; Basidiomycetes, such as Com'op/zora spp., Cochleobacter (CoWo/ws spp) .), Pleurotus spp.), Zewkws Spp·, P/ewroiw spp., Ρ〇η·α spp., genus Serpw/a Spp.) and dry age · genus (Γ romyce.·? spp.), deuteromycetes (Deuteromycetes) 'such as sputum spp.), mycobacteria, Penicillium (spp.), wood Mycorrhizal (7Wc/2〇rwa SPP·), Alternaria spp.), Pseudostellaria (Spp.), and Zygomycetes, such as Mweor spp., and additionally, In the protection of stored products and harvests, the following yeast fungi Notable: Candida spp.) and Saccharomyces cerevisiae (iSacc/zaromyce·? cerevbiie). 147475.doc -101- 201043139 Compounds I, II, and IV, and combinations thereof, can be used to improve plant health, respectively. The invention is also directed to a method of improving plant health by treating plants, their propagation material and/or plant growth or intended growth with an effective amount of Compound J, π and/or IV, and combinations thereof, respectively. The term "plant health" is understood to mean the condition of a plant and/or its harvest, which is determined on the basis of several indicators, either alone or in combination with one another, such as yield (eg biomass increase and/or valuable components). (extraction), plant vigor [eg plant growth accelerated and / or greener leaves ("greening effect")], quality (such as increased content or composition of certain ingredients) and resistance to abiotic and / or biological stress Receptive. The plant health indicators identified above may be interdependent or interdependent. The compounds of formulae I, II and IV may exist in different crystals with π biological activity. It is also the subject of the invention. The S substances I II and IV can be used as such or in the form of a composition for treating fungi with a fungicidally effective amount of an active substance, to protect against fungal attack or plants, plant propagation materials (such as seeds), soil, surface, materials Or space. Administration can be carried out before and after the fungal infection of the plant, plant propagation material (such as seeds), soil, surface, material or space. Prophylactic treatment with a combination of compounds I, II and/or IV itself π and/or IV may be followed by or during the implantation or transplantation of at least one compound J, a plant propagation material. The invention also relates to an agrochemical composition comprising a solvent or solid carrier and at least one compound I, II and/or IV, and the use thereof for controlling harmful fungi. 0 147475.doc • 102- 201043139 Agrochemical composition comprising fungicidal An effective amount of Compound I, II and/or IV. The term "effective amount" means that the amount of the composition or compound I, II and/or IV is sufficient to control harmful fungi or protective materials on cultivated plants without substantial damage to the treated plant. This amount can vary widely and depends on a number of factors such as the species of fungus to be controlled, the cultivated plant or material being treated, the climatic conditions and the particular compound employed. The compounds I, II and IV and their salts can be converted into a common type of agrochemical composition such as solutions, emulsions, suspensions, dusting powders, powders, pastes and granules. The type of composition will depend on the particular intended purpose; in each case it should ensure a fine and uniform distribution of the compounds of the invention. Examples of composition types are suspensions (SC, OD, FS), emulsifiable concentrates (EC), emulsions (EW, EO, ES), pastes 'tablets, wettable powders or dusting powders (WP, SP) , SS, WS, DP, DS) or granules (GR, FG, GG, MG) (which may be water soluble or wettable), and gel formulations for treating plant propagation materials such as seeds (GF ). ^ Composition type (eg SC, OD, FS, EC, WG, SG, WP, 〇 SP, SS, WS, GF) is usually used after dilution. Composition types such as DP, DS, GR, FG, GG, and MG are usually used without dilution. The composition is prepared in a known manner (see US 3, 〇6〇, 084, EP-A 707)

445 (About Liquid Concentrates); Browning: "Agglomeration", Chemical Engineering, December 4, 1967, 147-48, Perry's Chemical Engineer's Handbook, 4th Edition, McGraw-Hill, New York, 1963, 8-86 Pages and subsequent content; WO 91/13546, US 4,172,714 &gt; US 4,144,050 ' US 3,920,442, US 147475.doc -103-201043139 5,180,587, US 5,232,701, US 5,208,030, GB 2,095,558, US 3,299,566; Klingman: Weed Control as a Science (J. Wiley &amp; Sons, New York, 1961); Hance et al.: Weed Control Handbook (8th edition, Blackwell Scientific, Oxford, 1989) and Mollet, H_ and Grubemann, A: Formulation technology (Wiley VCH Verlag , Weinheim, 2001)). The agrochemical composition may also contain adjuvants commonly used in agrochemical compositions. The adjuvants used are selected depending on the particular application form and the active substance. Examples of suitable auxiliaries are solvents, solid carriers, dispersants or emulsifiers (such as other solubilizers, protective colloids, surfactants and adhesives), organic and inorganic thickeners, bactericides, anti-beads, Defoamers, (where appropriate) colorants and tackifiers or binders (for example for seed treatment formulations). Suitable solvents are water, organic solvents, such as mineral oil cranes with medium to high boiling points, such as kerosene or diesel, in addition to coal tar and oils of vegetable or animal origin; aliphatic hydrocarbons, cyclic hydrocarbons and aromatic hydrocarbons such as hydrazine a benzene, a dimercapto group, a stone butterfly, a tetrahydronaphthalene, an alkylated naphthalene or a derivative thereof; an alcohol such as decyl alcohol, ethanol, propanol, butanol and cyclohexanol; a diol; a ketone such as cyclohexanone; And γ-butyrolactone, fatty acid dimethylamine, fatty acids and fatty acid esters and strong polar solvents such as amines, such as hydrazine-methyl alpha ratio serotonin. The solid carrier is mineral soil, such as silicate, tannin, talc, kaolin, limestone, lime, chalk, red basalt, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground Synthetic materials, fertilizers, such as ammonium sulphate, ammonium sulphate, ammonium sulphate, urea, and plant-derived products such as gluten, bark, wood chips and nut clams, fiber 147475.doc -104- 201043139 plain powder and others Solid carrier. Suitable surfactants (adjuvants, wetting agents, tackifiers, dispersants or emulsifiers) are aromatic acid (such as lignin continuous acid (Borresperse® type, Borregard, Norway), benzoquinic acid, naphthalene Yellow acid (Morwet® type, Akzo Nobel, USA) and dibutylnaphthalenesulfonic acid (Nekal® type, BASF, Germany)) and metal salts, soil test metal salts and ammonium salts of fatty acids; , aryl aryl hydroxy acid, burnt sulphuric acid vinegar, lauryl ether sulfate, fatty alcohol sulphate, and sulfated cetyl salt, sulfated heptadecyl π ^ and sulfated stearyl salt, Sulfated fatty alcohol glycol ether; in addition to condensate of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde; polyoxyethylene octylphenyl ether, ethoxylated isooctylphenol, octylphenol, nonylphenol, alkane Phenyl polyglycol ether, tributyl phenyl polyglycol ether, tristearyl nonyl phenyl polyglycol ether, alkyl aryl polyether alcohol, alcohol and fatty alcohol / ethylene oxide condensate, Ethoxylated cannabis oil, polyoxyethylene ether alkyl ether, ethoxylated polypropylene oxide, lauryl alcohol polyglycol ether acetal, mountain Sugar alcohol esters, lignin sulfites ^ waste liquids, and proteins, denatured proteins, polysaccharides (such as mercapto cellulose), hydrophobic modified starch, polyvinyl alcohol (Mowiol® type, Clariant, Switzerland), polyphenolic acid Vinegar (Sokolan® type, BASF, Germany), polydecyloxylate, polyvinylamine (Lupasol® type, BASF, Germany), polyvinylpyrrolidone and copolymers thereof. Examples of thickeners (i.e., compounds which impart improved fluidity to the composition (i.e., compounds having high viscosity at rest and low viscosity during agitation) are polysaccharides and organic and inorganic clays such as Xanthan gum. (Kelzan®, CP Kelco, USA) 'Rhodopol® 23 (Rhodia, France) ' Veegum® 147475.doc -105- 201043139 (RT Vanderbilt, USΑ·) or Attaclay® (Engelhard Corp., NJ, USA). A bactericide can be added to preserve and stabilize the composition. Suitable bactericides are based on the following very fine halogens: dichlorophene and benzyl alcohol hemiacetal (Proxel® from ICI, or Acticide® RS from Thor Chemie, and Kathon from Rohm &amp; Haas) ® MK), and isothiazoline derivatives such as ketone isoindolinone and benzisothiazolinone (Acticide® MBS from Th〇r chemie). Examples of suitable antifreeze agents are ethylene glycol, propylene glycol, urea and glycerin. An example of a defoamer is a polyoxyl emulsion (such as Siiikon® SRE, Wacker,

Germany or Rhodorsil, Rhodia, France), long chain alcohols, fatty acids, salts of fatty acids, fluoroorganic compounds and mixtures thereof. Suitable colorants are low water soluble pigments and water soluble dyes. Examples which may be mentioned are the following names: rhodamin B, CI Pigment Red 112, C. L Solvent Red 1, Pigment Blue 15:4, Pigment Blue 15:3, Pigment Blue 15:2, Pigment Blue 15:1, pigment blue 8〇, pigment yellow i, pigment yellow 13, pigment red 丨丨, pigment red 48:2, pigment red 48:1, pigment red 57:1, pigment red 53: ',, orange 43, Pigment Orange 34, Pigment Orange 5, Pigment Green%, Pigment Green 7, Pigment White 6 Pigment 杬25, Authentic Violet 1 〇, Verification Violet 49, Acid Red 5 1, Acid Red 52, Acid Red 14, Acidity Blue 9, acid yellow 23, alkaline red 1 〇, alkali euphoria 108. Examples of the binders or binders are polyvinylpyrrolidone, polyvinyl acetate vinegar, polyvinyl alcohol and fibers (T) (Tyl〇se8, Shin_Etsu, Japan). Powders, spreading materials and dusting can be prepared by mixing Compound I and, if appropriate, 147475.doc-106-201043139 with at least one solid carrier or simultaneously grinding. «Preparation of granules coated with granules, impregnated granules and homogeneous granules by bonding the active substance to a solid carrier. Examples of solid cutting are materials, such as (four), salt, talc 1: active limestone, lime, white play, red basalt, loess:; white agro-stone, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, Grinded synthetic materials, fertilizers, such as ammonium sulfate 'ammonium phosphate, ammonium nitrate, urinary hydrazine

, and plant-derived products such as alfalfa, bark, wood chips and nuts shouting, cellulose powder and other solid carriers. Examples of the type of the composition are: 1) Type of the composition diluted with water i) Water-soluble concentrate (SL, LS) 1 part by weight of the compound of the present invention is dissolved in 9 parts by weight of water or a water-soluble solvent. Instead, a wetting agent or other auxiliaries are added. After dilution with water, the active substance dissolves. In this way, a composition having an active substance content of 1% by weight was obtained. Dispersible Concentrate (DC) 2 〇 The compound of the present invention is dissolved in 70 parts by weight of cyclohexanone with the addition of a hydrazine dispersant (e.g., polyvinylpyrrolidone). Dilute with water to obtain a dispersion. The active substance content was 20% by weight. /t^ ' iii) emulsifiable concentrate (EC) 15 parts by weight of the compound of the invention dissolved in 75 parts by weight of the calcium dodecylbenzene sulfonate and castor oil ethoxylate (each 5 parts by weight) In benzene. Dilute with water to give an emulsion. The active substance content of the composition was 15% by weight. 147475.doc -107- 201043139 iv) Emulsion (EW, EO, ES) 25 parts by weight of a compound of the invention dissolved in calcium dodecylbenzenesulfonate and castor oil ethoxylate (each 5 parts by weight) 35 parts by weight of xylene. This mixture was introduced into 3 parts by weight of water by means of an emulsifier (Ultraturrax) and a homogeneous emulsion was prepared. Dilute with water to give an emulsion. The active substance content of the composition was 25% by weight. v) suspension (SC, OD, FS;) in agitated ball mill, adding 1 part by weight of dispersant and wetting agent and parts by weight of water or organic solvent, grinding 2 parts by weight of the compound of the invention, to obtain fine Active substance suspension. Dilute with water to obtain a stable suspension of the active substance. The active substance content of the composition was 20% by weight. V1) Water-dispersible granules and water-soluble granules (WG, Sg) finely grind 5 parts by weight of a sulphate s by adding 50 parts by weight of a dispersant and a wetting agent and by means of technical equipment (for example, extrusion) , spray grade, grabbed bed) made of water-dispersible or water-soluble granules. Dilute with water to obtain a stable dispersion or solution of the t substance. The composition has an active substance content of 50% by weight. /. . Vl water-dispersible powder and water-soluble powder (wp, μ, shovel-stator grinder) under the addition of 25 parts by weight of a dispersant, a wet gel, grinding 75 parts by weight of the compound of the invention. The active substance is diluted with water 皙Evening ~, τ %, 疋 is a dispersion or solution. The active substance of the composition contains 75 parts. The inside is viii) gel (GF) in the mixing ball mill, adding 1G parts by weight of dispersant, ^ parts by weight 147475.doc 201043139 Kneeling agent wetting agent and 70 parts by weight of water or organic solvent, grinding 2 parts by weight of the compound of the invention 'to obtain a fine suspension of the active substance. A stable suspension of the active substance is obtained by dilution with water, whereby a composition containing 2% by weight (w/w) of the active substance is obtained. 2. Type of composition to be applied without dilution. The powder (DP, DS) can be finely ground to 5 parts by weight of the compound of the present invention and intimately mixed with 95 parts by weight of fine powdery high q-casting clay. Thus, a spreadable composition having an active material content of 5% by weight was obtained. X) Granules (GR, FG, GG, MG) Finely ground. 5 parts by weight of a compound of the invention and combined with 99.5 parts by weight of a carrier. The method is extrusion, spray drying or fluidized bed. Thus, granules which were applied without dilution at an active substance content of 〇·5% by weight were obtained. Xi) ULV solution (UL) 1 〇 Heavy injury The compound of the present invention is dissolved in 90 parts by weight of an organic solvent (e.g., xylene). Thus, a composition which was applied without dilution at an active substance content of 10% by weight was obtained. The agrochemical composition generally comprises from 0.01% to 95% by weight, preferably from 0'1% by weight to 90% by weight, most preferably from 5% by weight to 9% by weight. Active substance. Quality. The active substance is 90% to 100%, and the car is 95%/〇 to 100% pure.

(According to NMR spectrum) used. A water-soluble concentrate (LS), flowable concentrate (FS), powder for drying treatment (DS)' slurry treatment water dispersible powder (ws), soluble powder () emulsion (ES), emulsifiable concentrate (EC) and gel (GF) are commonly used for the purpose of treating plant propagation material (especially seeds) 147475.doc •109- 201043139. These compositions can be applied to plant propagation material (especially seeds) after dilution or without dilution. The composition in question is diluted from 2 to 10 times, and the active ingredient concentration of the ready-to-use preparation is from 1% by weight to 60% by weight, preferably from 3% by weight to 4% by weight. Administration can be carried out before or during sowing. Methods of applying or treating agrochemical compounds and compositions thereof to plant propagation materials, particularly seeds, are known in the art and include the application, coating, granulation, dusting, dipping of the propagation material. The method of application in the intrusion (in_furr〇w). In a preferred embodiment, the compound or composition thereof is applied separately to the plant propagation material by methods which do not induce germination (e.g., seeding, granulation, coating, and dusting). In a preferred embodiment, the suspension type (FS) composition is used for seed treatment. The FS composition typically comprises (1) (8) active material, a2 〇〇 surfactant, 〇 to 20 〇Μ antifreeze, 〇 to 400 g / 1 binder, 〇 to 200 g / Ι pigment and up to liters of solvent (preferably water). The active substance such as 5 hai can be used in the form of its composition by spraying, atomizing, dusting, spreading, brushing, dipping or pouring as the original, for example, a solution which can be directly sprayed, powder, suspension The liquid form, the dispersion, the emulsion, the oil knife liquid, the paste, the releasable product, the spreading material or the granules are used in the form of application, and the present invention is intended to be used in all cases. The active substances are distributed as finely as possible. The aqueous application form can be prepared from an emulsion concentrate, a paste or a wettable powder (sprayable powder, oil dispersion) by adding water. For the preparation of emulsions, pastes or oil dispersions, the shellfish (as is or dissolved in oil or solvent) can be homogenized by means of a wetting agent, tackifier, dispersant or milk 147475.doc •110- 201043139 In the water. Alternatively, a concentrate composed of an active substance, a wetting agent, a tackifier, a dispersing agent or an emulsifier and, if appropriate, a solvent or oil may be prepared, and such concentrates are suitable for dilution with water. / The concentration of the tongue substance in the ready-to-use preparation can be in a relatively wide range. The biomass of the sputum is generally from 0 '0001% by weight to 1 〇 by weight. Preferably, it is from 0.001% by weight to 丨 by weight. .

Such active substances can also be successfully used in ultra low volume methods (ULV), which can be applied with more than 95% by weight of active or even without additives. When used for plant protection, depending on the type of effect required, the application rate of the active substance is 〇.(9)i kg to 2 kg per hectare, preferably per hectare ^2 to 2 kg' more per hectare. 5k#〇9kg, specifically called 0.75 kg per hectare. ▲ When treating plant lean materials (such as seeds) by withdrawing powder, coating or soaking seeds, for example, 0.1 to 1 000 g, preferably H〇〇〇g, is generally required per 100 kg of plant propagation material (preferred seed). More preferably H〇〇g, and an active substance in an amount of from 5 to 100 g. The amount of active substance applied when used to protect or store the product depends on the type of application area and the desired effect. The amount of the protective material to be applied is usually, for example, 2 kg per cubic meter of treated material, preferably Q plus (4) kg of active material. Adding various types of bactericides and other fungicides to the active composition or oils containing the active substances, wetting agents, adjuvants, herbicides, 147475.doc •111- 201043139 and/or pesticides, These agents may be added to the composition of the present invention in a weight ratio of hi to 丨〇〇: 1, preferably 1:10 to 10:1, as appropriate, until the time of use. The adjuvants that can be used are specifically: organically modified polyoxyalkylenes such as Break Thru S 240®; alcohol alkoxylates such as Atplus 245®, Atplus MBA 1303®, Plurafac lf 300® and Lutensol ON 30®; EO/PO block polymers such as piur〇nic RpE 2035® and Genapol B®; alcohol ethoxylates such as Lutens〇1 χρ 8〇®; and sodium dioctylsulfosuccinate such as LeophenRA®. The compositions of the invention in the form of fungicides may also be present in the form of a premix with other active substances, such as herbicides, insecticides, growth regulators, fungicides or fertilizers, or as appropriate, until immediately prior to use. Square mixing (slot mixing). In many cases, the combination of the compounds I, n and/or IV in the form of a fungicide or the composition comprising the compounds with other fungicides broadens the range of fungicidal activity obtained or prevents the development of fungicides. Drug resistance. In addition, in many cases, synergies are obtained. The following list of active substances which may be used in combination with the compounds of the present invention is intended to illustrate possible combinations, but is not limited thereto: A) strobilurin, azoxystrobin, dimoxystrobin, fete Estrostrobin, fluoxastr〇, kresoxim-methyl 'metomin〇 str〇bin, orysastrobin, oxystrobin Picoxystr〇bin), baikemin 147475.doc -112- 201043139 (pyraclostrobin), ° pyribencarb, trifloxystrobin; 2-(2-(6-(3-chloro-2-indenyl) -phenoxy)-5-fluoro-pyrimidin-4-yloxy)-phenyl)-2-oxooxyimido-N-methyl-acetamide, 3-decyloxy-2-( 2-(N-(4-methoxy-phenyl)-cyclopropane-formamidothiomethyl)-phenyl)-methyl acrylate, (2-chloro-5.[1-(3) - mercaptobenzoyloxyimino)ethyl]benzyl)amino decanoate and 2-(2-(3-(2,6-dichlorophenyl)-1-indenyl-arylene Allylaminooxymethyl)-phenyl)-2-methoxyimino-N-methyl-ethenylamine; B) Carboxamide-methylhydrazine Carboxanilide): benalaxyl, benalaxyl-M, benodanil, bixafen, boscalid, carboxin, furfuryl Amine (fenfuram), fenhexamid, flutolanil, furametpyr, isopyrazani, isotianil, kiralaxyl, extinction Mepronil, metalaxyl, metalaxyl-M/mefenoxam, ofurace, oxadixyl, oxycarboxin, bacterium Amine (penthiopyrad), sedaxane, teci〇ftaiam, thifluzamide, tiadinil, 2-amino-4-methyl-thiophene. Sitting on -5-formaldehyde aniline, 2-gas-N-(l,l,3-tridecyl-indan-4-yl)-nicotine-brown amine, N-(3,,4',5, -Trifluorobiphenyl-2-yl)-3-difluorodecyl-1-indenyl-1H-indole-4-carboxamide, N-(4'-trifluoromethylthiobiphenyl_2 _ base)_3_difluorodecyl-1-methyl-1H-pyrazole-4-carboxamide, N-(2-(l,3-dimethylbutyl)-phenyl)-1, 3-Dimethyl-5-fluoro-1H-pyrazole-4-decylamine and N-(2-(l,3,3-tridecyl-butyl)-phenyl)-1,3-dioxin 5--5-fluoro-1H-pyrazole-4-decylamine; 147475.doc 113 - 201043139 - carboxylic morpholide: dimethomorph, flumorph, 0 ratio Pyrimorph; - benzoyl benzoate: flumetover, fluocicolide, fluopyram, zoxamide, 1^-(3 -ethyl-3,5,5-trimethyl-cyclohexyl)-3-carboxamido-2-hydroxy-benzamide; - other apoemic amines: carpropamid, dichlorocis Diclocymet, mandiproamid, oxytetracyclin, silthiofarm, and N-(6-methoxy-0 Bipyridin-3-yl)cyclopropane decylamine; C) azole-three-zero sitting: azaconazole, bitertanol, bromuconazole, cyproconazole , difenoconazole, diniconazole, diniconazole-M, epoxicbnazole, fenbuconazole, fluoroquinone. Fluquinconazole, flusilazole, flutriafole, hexaconazole, imibenconazole, ipconazole, metconazole, micney (myclobutanil), oxpoconazole, paclobutrazole, penconazole, propiconazole, prothioconazole, simeconazole, derkeley Tebuconazole), tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, 1-(4-gas-phenyl)-2- ([1,2,4]triazol-1-yl)-cycloheptanol; 147475.doc -114- 201043139 - σ米唾: cyazofamid, ima.zalil, rice mark Peflirazoate, prochloraz, triflumizole; - benzopyrene: benomyl, carbendazim, fuberidazole, thiabendazole ); other: eth0 ethaboxam, etridiazole, evil Hymexazole and 2-(4-a-phenyl)-N-[4-(3,4-dimethoxy-phenyl)-isoxazole-5-yl]-2-prop-2- Alkynyloxy-acetamide; D) heterocyclic compound-. Ratio σ: fluazinam, pyrifenox, 3-[5-(4-chloro-phenyl)-2,3-didecyl-isoxazol-3-yl]- Pyridine, 3-[5-(4-methyl-phenyl)-2,3-dimethyl-isoxazol-3-yl]-pyridine, 2,3,5,6-tetrachloro-4- Decanesulfonyl-pyridine, 3,4,5-tripyridine-2,6-dicarbonitrile, N-(l-(5-bromo-3-chloro-pyridin-2-yl)-ethyl) -2,4-di-nicotinine decylamine, N-[(5-bromo-3-gas-D ratio bit-2-yl)-two winds^-2,4-digas-in the test amine, - Bite bite: bupirimate, cyprodinil, diflumetorim, fenarimol, ferimzone, mepanipyrim, nitrapyrin , nuarimol, pyrimethanil; - brigade: triforine; - ° ratio D: fludioxonil, fludioxonil; - linlin: Aldimorph, dodemorph, dodemorph-acetate, fenpropimorph, tridemorph; -D bottom: fenpropidin ; 147475.doc -115- 201043139 - Diterpenoid Fluoroimide, iprodione, procymidone, vinclozolin; - non-aromatic 5-membered heterocyclic ring: famoxadone, fenamidone , flutianil, octhilinone, probenazole, 5-amino-2-isopropyl-3-oxo-4-o-tolyl-2,3-dihydro Pyrazole-1-thiodecanoic acid S-allyl ester; - Others: acidified benzoxoxane-s-a-sodium-S-methyl-A-benzoate-s-methyl ), anilazine, blasticidin-S, captafol, captan, chinomethionate, dazomet, minocycline (debacarb), diclomezine, difenzoquat, difenzoquat-methylsulfate, fenoxanil, folpet, oxolinic Acid), piperalin, proquinazid, pyroquilone, quinoxyfen, triazoxide, tricyclazole ), 2-butoxy-6-moth-3-propyl decen-4-one, 5-chloro-1-(4,6-dimethoxy-pyrimidin-2-yl)-2-fluorenyl -1H-benzimidazole, 5-chloro-7-(4-mercaptopiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-[1,2,4]triazole And [1,5-a] mouth bite and 5-ethyl-6-octyl-[1,2,4]tris-[1,5-a]-doped-7-ylamine; E) amine group Phthalate &quot;thiamine carboxylic acid vinegar and dithiocarbamate formic acid vinegar, such as ferbate, mancozeb, maneb, metam, continuum (methasulfocarb), metiram, propineb, thiram, zineb, 147475.doc -116- 201043139 ziram; - urethane Ester: benthiavalicarb, diethofencarb, iprovalicarb, propamocarb, propamocarb hydrochloride, valiphenal and N-l -(l-(4-cyano-phenyl)ethanesulfonyl)-butan-2-yl)carbamic acid-(4-fluorophenyl) ester; F) other active substances

- steroids: guanidine, dodine, tannin, guazatine, bismuth sulphate, iminoctadine, dioctylamine triacetate, ginseng Acid) diinoctylamine (iminoctadine-tris (albesilate)) i - antibiotics: kasugamycin, hydrated salbutamycin, streptomycin, polyoxin, tyrosin A (validamycin A); - Nitrophenyl derivatives: binapacryl, dinobuton, dinocap, nitrothal isopropyl, tecnazene - Organometallic compounds: fentin salts, such as fentin acetate, fentin chloride, fentin hydroxide; - sulfur-containing heterocyclic compounds : dithianon, isoprothiolane; - organic scale compounds _ edifenphos, fosetyl, fosetyl-aluminum, propyl sheisson (iprobenfos) ), arsenic acid and its salt, white pine (pyrazophos), gram 147 475.doc,-117- 201043139 pine (tolclofos-methyl); - organochlorine compounds: chlorothalonil, dichlofluanid, dichlorophen, flusulfamide, Hexachlorobenzene, pencycuron, pentachlorphenole and its salts, phthalide, quintozene, thiophanate methyl, Tolylfluanid, N-(4-chloro-2-nitro-phenyl)-N-ethyl-4-mercapto-benzenesulfonamide; - Inorganic active substance: Bordeaux mixture , copper acetate, copper hydroxide, copper oxide, basic copper sulfate, sulfur; - other: biphenyl, bromopol, cyflufenamid, cymoxanil, diphenylamine -amin), metrafenone, mildiomy-cin, oxine-copper, prohexadione-calcium, spiroxamine, sulfhydryl Yifaling, N-(cyclopropylmethoxyimino-(6-difluoro-methoxy-2,3-difluoro-phenyl) -mercapto)-2-phenylacetamide, N'-(4-(4-chloro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N- Ethyl-N-mercaptopurine, N'-(4-(4-fluoro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl- N-methylformamidine, Ν-(2-mercapto-5-trifluoromethyl-4-(3-trimethyldecyl-propoxy)-phenyl)-N-ethyl-N- Methylformamide, Ν·-(5-difluorodecyl-2-mercapto-4-(3-tridecylfluorenyl-propoxy)-phenyl)-indole-ethyl-hydrazine-methyl 2-(1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-ethinyl]-piperidin-4-yl}-thiazole-4-oxime Acid methyl-(1,2,3,4-tetrahydronaphthalen-1-yl)-bristamine, 2-{1-[2-(5-fluorenyl-3-trifluoromethyl-p-wow- 1-yl)-ethylidene] bottom 147475.doc -118- 201043139 bite-4-ylthiazole-4-carboxylic acid methyl-(1〇-1,2,3,4-tetrahydronaphthalen-1-yl -醯月女,乙自文6 -Secondyl _8_Fluorine 2,3_dimethyl-B Queron _4_yl g and methoxy-acetic acid 6-t-butyl _8 _Fluoro-2,3-dimethyl-quinolin-4-yl ester. G) growth regulators abscisic acid, amidochlor, ancymidol, 6-stactylaminoguanidine, brassinolide (bras_sin〇lide), bismuth ( Butralin), chlormequat (chlormequat chloride), chloramphenicol (ch〇line chl〇ride), cyclanilide, daminozide, bite Acid (dikegulac), dimethi-pin, 2,6-dimethyl. ratio. Ethephon, f;umetraiin, β-frozen (fjUIprimid〇i), flu-thiacet, forchl〇rfenuron, Gibberellium Acid (gibberellic acid), inabenfid, 0 bow-3-acetic acid, maleic hydrazide, mefluidide, mepiquat Mepiquat chloride, naphthaleneacetic acid, N-6-benzyl adenine, paclobutrazol, pro-hexadione (4 bows), prohydro-jasmon ), thidiazuron, triapen-thenol, tributyl trithiophosphate, 2,3,5-trimo-benzoic acid, trinexapac-ethyl and thinning H) Herbicide - acetochlor, alachlor, butachlor, dimethachlor, dimethenamid, snail Flufenacet, benzene, mefenacet, metolachlor, metazachlor, 147475.doc -119- 201043139 napropamide Naproanilide, pethoxamid, pretilachlor, propachlor, thenylchlor; - amino acid derivatives: biarylfos, grass Glyphosate, glyphosate, sulfosate; - aryloxyphenoxypropionate: clodinafop, cyhalofop-butyl, °°°草草灵(fenoxaprop ), ° fluazifop, haloxyfop, ° evil, metamife, oxalic acid Vinegar (quizalofop-P-tefuryl); - 联°°°: diquat, paraquat; -(thio)amino carboxylic acid vinegar: asulam, butachlor (butula) Butylate), carbeamide, desmedipham, dimepiperate, eptam (EPTC), esprocarb, molate, pingcao Orbencarb, phenmedipham, prosulfocarb, pyributicarb, thiobencarb Trilate (triallate); - cyclohexanedione: butroxydim, clethodim, cycloxydim, profoxydim, sethoxydim, Tepulaloxydim, tralkoxydim; - dinitroaniline: benfluralin, ethalfluralin, oryzalin, diterpenoid Pendimethalin), prodiamine, trifluralin; 147475.doc •120- 201043139 - diphenyl ether: trifluoro&gt; acifluorfen, aclofenf, bifenfen ( Bifenox), diclofop, ethoxyfen, fomesafen, lactofen, oxyfluorfen; Nitrile: bromoxynil, dichlobenil, ioxynil; - oxime ketone: imazamethabenz, methoxymetazone, methyl p rice (imazapic), °m β sitting in acid (imazapyr), imazaquin acid (imazaquin), mouth rice salic acid (imazethapyr); - benzene Oxyacetic acid: oxachlorin 〇1〇11^1)1: 〇卩), 2,4-diphenoxyacetic acid (2,4-D), 2,4-DB, dichlorprop , MCPA, MCPA-thioethyl, MCPB, 2-methyl-4-propionic acid (mecoprop); -° ratio ° Qin: chloridazone, flufenpyr-ethyl, flu ° fluthiacet, norflurazone, pyridate; -° ratio: aminopyralid, clopyralid, 0 vs. fluramide (diflufenican), dithiopyr, fluridone, fluroxypyr, picloram, picolinafen, thiazopyr - Continued carbamide: amidosulfuron, azimsulfuron, bensulfuron, chlorimuron-ethyl, chlorsulfuron (chl〇rsulfuron), Cinosulfuron, CyCi〇suifaniuron, ethoxysulfuron, flazasuifuron, flumasulfuron 147475.doc • 121 - 201043139

(flucetosulfuron), flu port, flupyrsulfuron, foramsulfuron, chlorine, halosulfuron, squatting, imazosulfuron, scutellaria (iodosulfuron), mesosulfuron, metsulfuron-methyl, nicosulfuron, oxasulfuron, fluoroprime primisulfuron , prosulfuron, (prosulfuron). Pyrosulfuron, rimsulfuron, sulfometuron, sulfosulfuron, thifensulfuron, ether benzene sulphide Triasulfuron), tribenuron, trifloxysulfuron, triflusulfuron, tritosulfuron, 1-((2-chloro-6-propyl) -imidazo[1,2-b]pyridazin-3-yl)sulfonyl)-3-(4,6-dimethoxy-pyrimidin-2-yl)urea;

- Triazine: ametryn, atrazine, cyanazine, dimethametryn, ethiozin, hexazinone, benzoquinone Grass _ (metamitron), metribuzin, prometryn, simazine, terbuthylazine, terbutryn, triaziflam; -urea: chlorotoluron, daimuron, diuron, fluometuron, isoproturon, linuron, toluene Methabenzthiazuron), tebuthiuron; - other lactic acid synthase inhibitors: bispyridinose (bi spy rib ac- 147475.doc -122- 201043139

Sodium), chlorine S, cloransulam-methyl, diclosulam, flusarusm, 'flucarbazone, flumetsulam , performance grass. Metasulam, ortho-sulfamuron, penoxsulam, propoxycarbazone, pyribambenz-propyl, ° Pyribenzoxim, pyrifalid, pyriminobac-methyl, pyrimisulfan &gt; pyrithiobac, pyroxasulfone, methoxy Pyromycin (pyroxsulam); - Others: amine amicarbazone, aminotriazole, anilofos, beflubutamid, benazolin, Bencarbazone, benfluresate, benzofenap, bentazone, benzobicyclon, bromacil, chlorfenapyr Bromobutide), butifenacil, butamifos, butamifos, cafenstrole, carfentrazone, cinidon-ethlyl, enemy Chlorothal, cinmethylin, clomazone, benzyl Cuyluron, cyprosulfamide, dicamba, wild swallow, diflufenzopyr, drechslera monoceras, endothal , ethofumesate, etobenzanid, fentrazamide, flumiclorac-pentyl, flumioxazin, flufenacil Flupoxam, fluorochloridone, flurtamone, 147475.doc -123- 201043139 indanofan, isoxaben, isoxaben Isoxaflutole, lenacil, propanil, propyzamide, quinclorac, quinmerac, methyl stone yellow grass | (mesotrione) ) 'Methyl decanoic acid, naptalam, oxadiargyl, oxadiazon, oxaziclomefone, pentoxazone, pentoxazone. Sitting on pinoxaden, pyraclonil, pyraflufen-ethyl, pyrasulfotol, pyrazoxyfen, pyrazolynate , quinoclamine, saprofenacil, sulcotrion, sulfentrazone, terbacil, tefbryltrione 'teber Ketone (tembotrione), thiencarbazone, topramezone, 4-hydroxy-3-[2-(2-methoxy-ethoxyindolyl)-6-trifluoromethylpyridinium 3-carbonyl]-bicyclo[3.2.1]oct-3-en-2-one, (3-[2-chloro-4-fluoro-5-(3-methyl-2,6-di-oxyl) 4-trifluoromethyl-3,6-dihydro-2H-pyrimidin-1-yl)-phenoxy]pyridin-2-yloxy)-acetate, 6-amino-5-gas 2-cyclopropyl-pyrimidine-4-decanoate, 6-gas-3-(2-cyclopropyl-6-mercapto-phenoxy)-pyridazin-4-ol, 4-amino group -3 -Chloro-6-(4-chloro-phenyl)-5-fluoro-0 to 0-but-2-carboxylic acid, 4-amino-3-gas-6-(4-chloro-2-fluoro-3 -nonyloxy-phenyl)-pyridin-2-indole decyl ester and 4-amino-3-gas-6-(4_gas_3_dioxanyl-2-fluoro-benzene ) - pyridine _2_ Yue acid ester. I) Insecticides - Organic (thio) phosphates: acephate, azamethiphos, azinphos-methyl, chlorpyrifos, chlorpyrifos-methyl Kefensong 147475.doc •124· 201043139 Ο

(chlorfenvinphos), dizizon, dichlorvos, dicrotophos, dimethoate, disulfoton, ethion, fenitrothion , fenthion, isoxathion, malathion, methamidophos, methidathion, methyl-parathion, mevinphos, ya Monocrotophos, oxydemeton-methyl, paraoxon, parathion, phenthoate, phosalone, phosmet , phosphamidon, phorate, phoxim, pirimiphos-methyl, profenofos, prothiofos, sulprophos, Tetrachlorvinphos, terbufos, triazophos, trichlorfon; - amino phthalate: alanycarb, aldicarb, invulnerable Ben (bendiocarb), Benfke (benfbra) Carb), carbaryl, carbofuran, carbosulfan 'fenoxycarb', fenoxycarb, furathiocarb, metiocarb, nanet (methomyl), oxamyl, pirimicarb, propoxur, thiodicarb, triazamate; - pyrethroid: Allethrin, bifenthrin, cyfluthrin, cyhalothrin, cyphenothrin, cypermethrin, alpha-cypermethrin, beta-race Zingning, ξ-赛pernin (zeta-cypermethrin), deltamethrin, esfenvalerate, effenin 147475. Doc -125- 201043139 (etofenprox), fenpropathrin, fenvalerate, imiprothrin, lambda-cyhalothrin, permethrin, puarinin Prallethrin), pyrethrins I and II, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, tetramethrin ), tralomethrin, transfluthrin, profluthrin, dimefluthrin; - insect growth regulator: a) chitin synthesis inhibition Agent: Benzamidine urea: chlorfluazuron, cyromazine, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, locust Lufenuron, novaluron, teHubenzuron. , triflumuron; buprofezin, diofenolan, hexythiazox, etoxazole, clofentazin; b) ecdysone antagonist : hafenofozide, methoxyfenozide, tebufenozide, azadirachtin; c) juvenoid: pyriproxyfen, beauty Mesoprene, fenoxycarb; d) lipid biosynthesis inhibitors: spirodiclofen, spiromesifen, spirotetramat; Agent/antagonist compounds: clothianidin, dinotefuran, imidacloprid, thiamethoxam, nitenpyram, acetamiprid, Thiacloprid, 1-(2-gas-thiazol-5-ylindenyl)-2-niminoimido- 147475. Doc -126· 201043139 3,5-Dimethyl-[1,3,5]triazide; -GABA antagonist compound: endosulfan, ethiprol, fenapini (fipronii), vanipipr〇i, fiyrazil (PyrafluPro1), pyriprol, 5-amino-1-(2,6-dichloro-4-indolyl-phenyl) _4-Aminosulfinyl-1H-pyrazole-3-thiodecanoic acid decylamine; - Macrolide lactone: abacitin, emamectin, smectin; (milbemectin), lepimectin, spinosad, spinetoram; - mitochondrial electron transport inhibitor (METI) I acaricide: fenazaquin, Pyridaben, tebufenpyrad, tolfenpyrad, flufenerim; -METI II and bismuth compounds: acequinocyl, fluacyprim, Hydramethylnon; Uncoupler: chlorfenapyr; - Oxidation acidification inhibitors: cyhexatin, diafenthiuron, fenbutatin oxide ), Propargite; - moulting disruptor compound: cryomazine; - mixed-function oxidase inhibitor: piperonyl butoxide; - nanochannel blocker: Indek ( Indoxacarb), metaflumizone; -benbeniaz, bifenazate, cartap, flonicamid, pyridalyl , pymetrozine, sulfur, thiocyclam, flubendiamide 147475. Doc -127· 201043139 (flubendiamide), chlorantraniliprol, cyazypyr (HGW86); cyenopyrafen, flupyrazofos, cyflumetofen, Amidoflumet, imicyafos, bistrifiuron, and pyrifluquinazon 〇 The present invention further relates to an agrochemical composition comprising at least one compound I, II And/or IV (component 1) and at least one other active substance (component 2) suitable for plant protection, for example selected from the group A) to group I) (especially another fungicide, for example one or more from A fungicide according to group A) to group F) as described above and, if appropriate, a mixture of suitable solvents or solid carriers. Because many of their mixtures show higher efficiency against harmful fungi at the same application rate, they are of particular interest. Furthermore, a mixture of compound IV and at least one fungicide from the group of Α) to F) as described above against harmful fungi is compared to individual compounds I, II or IV or from groups A) to F) The agents are more effective against their fungi. A synergistic effect can be achieved by the application of the compounds I, II and/or IV together with at least one active substance from the guanidine group to the Sichuan, i.e. a simple addition (co-mixture) is achieved which is greater than the individual effects. I. According to the present invention, it is to be understood that the application of the compound 11 and/or 1 000 together with at least one other active substance means at least one compound of the formula I, II and/or IV and at least one other active substance in a fungicidal effective amount. At the same time, it occurs in harmful fungi or their habitats that are to be controlled, such as infected plants, materials (especially seeds), surfaces, materials or soils, as well as plants and plant propagation materials (especially species) 147475. Doc -128· 201043139 Sub) soil, surface, material or space). This can be achieved by simultaneous (combination (in the form of a septic compound) or separately) or continuous application of the compounds I, II and/or IV and at least one other active substance, wherein - The time interval between the chords is selected to ensure that the active substance applied first is still present in sufficient quantity at the site of action when the other substances are applied. The order of application is not critical to the work of the present invention. A combination of the invention in a one-component mixture, i.e., an active substance comprising a compound I, II or IV (component 1) ❹ and a further/tongue substance (component 2) (for example, a group from group A) The weight ratio of component 丨 to component 2 generally depends on the nature of the active substance used, and is usually in the range of 1:1 (10) to · i, often in the range of 1:50 to 50:1. Preferably, it is in the range of 1:2〇 to 2〇:1, more preferably in the range of 1:10 to 10:1 and in particular in the range of 1:3 to 3:1. In a ternary mixture, ie comprising a compound j, π &amp; /4ΐν (component υ and the first other active substance (component 2) and a second other active substance (component 〇 3) (for example two from Α) The weight ratio of component 1 to component 2 in the composition of the invention of the active substance of group I) is dependent on the nature of the active substance used, preferably in the range of 1:50 to 50:1 and Especially in the range of 1:1〇 to 1〇:1. The weight of component 1 and component 3 is preferably in the range of 1:5 Torr to 5 Å:1 and especially in the range of 1:10 to 10:1. The components can be used to prepare the compositions of the present invention either individually or in part or in combination with each other. It may also be further packaged and used in the form of a combination composition such as a kit of dispensing parts. In one embodiment of the invention, the kit may include one or more (including 147475. Doc • 129- 201043139 All) can be used to prepare the components of the standard agrochemical composition. For example, the kit may comprise one or more fungicide components and/or adjuvant components and/or insecticide components and/or growth regulator components and/or herbicides. One or more components may have been combined or pre-formulated. In embodiments in which two or more components are provided in a kit, the components may have been combined and packaged as such in a single container such as a vial, bottle, can, sachet, pouch or can. In other embodiments, two or more components of the kit may be packaged, ie, not pre-formulated. Thus, the kit may include one or more individual devices such as vials, cans, bottles, sachets, bags or cans, each containing an individual component of the agrochemical composition. In either form, one of the sets is $ The fraction may be administered separately or separately from the other components or in the form of a component of the combination composition of the invention for preparing the alpha compound of the invention. The user typically has a predosage device, a backpack spray, a spray tank. Or a sprayer to apply the composition of the invention. Here, the agricultural use ♦. . Further, the σ system is made up of water and/or a buffer to a desired application concentration, and it is appropriate to add other auxiliaries, and thus obtain a ready-to-use spray liquid or agrochemical composition of the present invention. The agricultural effective area per hectare is usually applied to 5 liters of 'preferably 100 liters to 4 liters of ready-to-use spray liquid. According to one embodiment, the individual components of the composition of the invention, such as part of the formula - two _ 70 or a portion of the mixture, may be 'incorporated by the user' in the spray tank and may be added as appropriate Other additives (slot mixing). In other embodiments, the individual components or portions of the compositions of the invention are premixed. The knives comprise, for example, the compounds I, II and/or 乂 and/or the actives from the group A) to the group), and the knives can be mixed by the user in the spray tank and When appropriate 147475. Doc -130- 201043139 Other additives and additives (tank mix) can be added. In another κ embodiment, the individual components or portions of the compositions of the present invention are premixed, and the knives, for example, comprise the compound 丨, π and/or ... and/or from the Α) group to the U group / tongue 〖biomass The components may be administered in combination (e.g., after tank mixing) or continuously. A mixture comprising the compound I, hydrazine and/or 1 part (component hydrazine and at least one selected from the group consisting of hydrazine) and especially the active substance (component 2) selected from the group consisting of: , ethenamide, fluoxastrobin, kexinxin, acesulfame, oxystrobin, kekemin and trifluoro-sensitive. Mixtures comprising Compounds I, II and/or IV (component quinone and at least one selected from the group consisting of carboguanamines and especially selected from the following active substances (Component 2) are also preferred: baikefen, baikele' Sedative, cycloheximide, chlordane, isopizamide, dextromethorphan, furosemide, dapren, flumorph, flu TI bismuth (picobenzamid), Hydrazine, gupamine, dipropionin and N-(3',4',5'-trifluorobiphenyl-2-yl)-3-difluoromethylmethyl_1H_pyrazole 4-carbamamine. A mixture comprising the compounds I, II and/or IV (component 1) and at least one excipient selected from group c) and especially selected from the following active substances (component 2) is preferably: cyclohexyl Block, Waiting Klip, Ep, fluoroquinazole, hydrazine, defoliation, chlorpyrifos, micney, pingke, pugli, prothioconazole, three taifen, three tailong, dekli, Four Klee, Sterilization, Poker, Race, Free, Beffen and Ethaboxam. Mixtures comprising a compound I, II and/or IV (component 1) and at least one heterocyclic compound selected from the group D) and especially selected from the group consisting of the following active substances (component 2) are also 147475. Doc •131- 201043139 Preferred: chlorpromazine, cypro, fenremo, chlorpyrifos, pimeni, safranin D vine, carbendazim, fenfluster, didefine, benzene rust Pyridine, Yiputong, Xikening, Fanzhitong, Imidazolidone, chlorpyrifos, Puquinaz, acidified benzoxazole-s-methyl ester, tetrachlordane, fore, cyanamide, Vonofol and 5-ethyl-6, octyl-π, 2,4]triazolopyrimidine-7-ylamine. Included are compounds I, π and/or ... (component 丨) and at least one amine decanoate selected from the group E) and are especially selected from the group consisting of zinc manganese, smear, sputum, sylvestre, dermatology, sputum An active substance of a mildew, a phenothiamine and a propamocarb (a mixture of phantom components is also preferred. It comprises a compound I, π and/or 1 ¥ (component 丨) and at least one fungicide selected from the group and Mixtures of especially active substances (component 2) selected from the following are also preferred. Nitrile sulphide 'triphenyltin salt (such as triphenyl vinegar), forsythia, forsylate aluminum, H3P 〇 3 and its salts, tetra-isophthalonitrile, Yifaling, methyl chlorhexate, copper acetate, Copper hydroxide, copper oxide, copper sulfate, sulfur, gram, fenfennon and snail pentylamine. The invention therefore further relates to a composition comprising a compound I, II and/or IV (component 1) and another active substance (component 2) selected from the group B of Table B- 1 to b_346 line "Component 2" one stop. Further consistent examples relate to compositions 1 to b-346 listed in Table B, wherein one of the tables B is in each case corresponding to a compound (component) comprising an individualized formula I, II or IV in the present specification. 1) and fungicidal compositions of the individual active substances (component 2) from groups A) to I) as described in the discussion. The composition preferably comprises a synergistically effective amount of active material. Table B: Contains an individualized compound 〖, ^ or ... and from group a) to 〇 147475. Doc • 132- 201043139 Composition of another active substance in a mixture of components 1 Component 2 B-1 An individualized compound I, II or IV Atomin B-2 An individualized compound I, II or IV Amine B-3 An individualized compound I, II or IV enestrobin B-4 An individualized compound I, II or IV fluoxastrobin B-5 An individualized compound I, II or IV 克收欣 B- 6 An individualized compound I, II or IV phenoxybamine B-7 an individualized compound I, II or IV acesulfame B-8 an individualized compound I, II or IV oxystrobin B-9 Individualized compound I, II or IV 100g-sensitive B-10 an individualized compound I, II or IV than Benka B-11 an individualized compound I, II or IV trifluoro-sensitive B-12 an individualized compound I, II or IV 2-(2-(6-(3-Gas-2-methyl-phenoxy)-5-fluoro-bitter _ 4-yloxy)-phenyl)-2-methoxy Amino-N-mercapto-ethinamine B-13 An individualized compound I, II or IV 2-(o-((2,5-dimethylphenoxymethylene)phenyl)-3-yl Methyl methacrylate B-14 An individualized compound I, II or IV 3-decyloxy-2-(2-(N -(4-Methoxy-phenyl)-cyclopropanimide fluorenylthioindolyl)-phenyl)-decyl acrylate B-15 An individualized compound I, II or IV 2-(2- (3-(2,6-diphenyl)-1-indenyl-allylpropenyl [aminooxyindenyl)-phenyl)-2-methoxyimino] N-methyl-B Indole B-16 An individualized compound I, II or IV Bendula B-17 An individualized compound I, II or IV 右本达乐~~ B-18 An individualized compound I, II or IV B-19 An Individualized Compound I, II or IV Baikefen~~ B-20 An Individualized Compound I, II or IV Baikly B-21 An Individualized Compound I, II or IV Brassin B-22 Individualized compound I, II or IV oxifenamide ~~ B-23 An individualized compound I, II or IV Cycloheximide -~~ B-24 An individualized compound I, II or rv Fludonine - B -25 An individualized compound I, II or IV Folabi ~~ B-26 An individualized compound I, II or IV Idezed Zami B-27 An individualized compound I, π or rv Ivory B-28 An individualized compound I, π or rv Kaida Le ' B-29 an individualized compound I, II or r v 3 Puning B-30 An individualized compound I, π or rv 灭达-- B-31 An individualized compound I, II or IV dextromethorphan B-32 an individualized compound I, II or IV Indoleamine ~ B-33 An individualized compound I, hydrazine or IV octopus 147475. Doc •133· 201043139 Mixture Component 1 Component 2 B-34 An Individualized Compound I, II or IV Jia Baoxin B-35 An Individualized Compound I, II or IV B-36 An Individualized Compound I, II or IV色达安B-37 An individualized compound I, hydrazine or IV gram 煳 'B-38 an individualized compound I, II or IV —--- B-39 an individualized compound I, hydrazine or IV B-40 An individualized compound I, II or IV Amino-4-methyl ϋ5_甲酿笑 B-41 An individualized compound I, II or IV 查^-(1,1,3-:曱基·茚满冰幕)·Nicotine guanamine B-42 An individualized compound I, II or IV Ν-(3·,4ΐ,5,-trifluorobiphenyl)_3·difluoromethyl _; _ Pyrazole-4-methyl guanidine face B-43 An individualized compound I, II or IV 1 (4'-trifluoromethylthiobiphenyl-2-yl)_3_difluoromethyl n-methyl-lH- n ratio sal-4-carboxamide B-44 an individualized compound I, II or IV N-(2-(l,3-dimercapto-butyl)phenyl)13_dif-yl-5 -Fluoro-1Η-»比嗤-4-曱醯amine B-45 An individualized compound I, II or IV is called 2-(1,3,3-tridecyl-butyl)-phenyldifluorenyl-yl -5-lt-lH·0 Jun-4·carbamamine B-46 An individualized compound I, II or IV daxanphene B-47 an individualized compound I, II or IV fluocillin B-48 an individualized compound I, II or IV °比林林 B-49 An individualized compound I, II or IV fluoxetine B-50 An individualized compound I, II or IV chaotic bacteriocin B-51 an individualized compound I, hydrazine or IV fluoro Pyridoxamine B-52 An individualized compound I, II or IV saponin B-53 An individualized compound I, hydrazine or IV N-(3-ethyl-3,5,5-trimethyl-ring Hexyl)-3-indenyl-2-hydroxy-benzimidamine B-54 an individualized compound I, II or IV gupamine B-55 an individualized compound I, II or IV dioxazole B -56 An individualized compound I, II or IV Dipropionin B-57 An individualized compound I, II or IV oxytetracycline B-58 an individualized compound I, II or IV thiastrobin B-59 An individualized compound I, hydrazine or IV N-(6-decyloxy-pyridin-3-yl)cyclopropanoic acid decylamine B-60 An individualized compound I, II or IV Azagon alpha sitting B-61 An individualized compound I, II or IV than Dorong B-62 An individualized compound I, hydrazine or IV bromoxene B-63 an individualized compound I, II or IV Cyclosyl-B-64 an individualized compound I, II or IV holly B-65 an individualized compound I, Π or IV 达利 B-66 an individualized compound I, II or IV dextran B-67 an individualized compound I, II or rv Eppia B-68 an individualized compound I, hydrazine or IV fen Block B-69 An individualized compound I, II or IV Fluoroquinazole B-70 An individualized compound I, II or IV m矽 B-71 An individualized compound I, hydrazine or IV Ref. 134· 147475 . Doc 201043139 Mixture component 1 Component 2 B-72 An individualized compound I, II or IV Fickley B-73 An individualized compound I, II or IV Easy amine block B-74 An individualized compound I, II or IV依普克嗤B-75 An individualized compound I, II or IV Cyclones B-76 An individualized compound I, II or IV McAfee B-77 An individualized compound I, II or IV oxazide B- 78 An individualized compound I, II or IV Bark B-79 An individualized compound I, II or IV Dink B-80 An individualized compound I, II or IV Puckley B-81 an individualized compound I, II or IV prothiotoxin. S-B-82 an individualized compound I, II or IV fluorazole B-83 An individualized compound I, II or IV De Klee B-84 An individualized compound I, II or IV Si Keli B-85 An individualization Compound I, II or IV Ditai B-86 An individualized compound I, II or IV Santarem B-87 An individualized compound I' II or IV sterilized. S-B-88 An individualized compound I, II or IV 坐 ° 坐 B-89 An individualized compound I, II or IV 1-(4-gas-phenyl)-2-([1,2,4] Triazol-1-yl)-cycloheptanol B-90 An individualized compound I, II or IV saponin B-91 an individualized compound I, II or IV thiophene B-92 an individualized compound I, II or IV Sulfate Sulfate B-93 An Individualized Compound I, II or IV Rice Dip B-94 An Individualized Compound I, II or IV Poker La B-95 An Individualized Compound I, II or IV Safford Block B-96 an individualized compound I, II or IV free of B-97 an individualized compound I, II or IV befenfen B-98 an individualized compound I, II or IV wheat spike B-99 Individualized compound I, II or IV rotted B-100 an individualized compound I, II or IV ethaboxam B-101 an individualized compound I, II or IV eduli B-102 an individualized compound I, II Or IV carbendazim B-103 an individualized compound I, II or IV 2-(4-chloro-phenyl)-N-[4-(3,4-dimethoxy-phenyl)-isoxazole -5-yl]-2-prop-2-ynyloxy-acetamide B-104 an individualized I, II or IV GIJ-B-105 An individualized compound I, II or IV Tefino B-106 An individualized compound I, II or IV 3-[5-(4-gas-phenyl)- 2,3-Dimethyl-isoxazol-3-yl]-° 嗓B-107 an individualized compound I, II or IV 3-[5-(4-indolyl-phenyl)-2, 3-Dimercapto-isoxazol-3-yl]-α than lake B-108 an individualized compound I, II or IV 2,3,5,6-tetraqi_4_曱 续 酿 - - 〇 is subjected to B-109 an individualized compound I, II or IV 3,4,5-dichloro-° ratio biting 2,6-dicarbonitrile B-110 an individualized compound I, II or IV 1^- (1-(5-&gt;Smelly-3-chloro-0-precipitate-2-yl)-ethyl)-2,4-dioxane-in the case of decylamine 147475. Doc -135 - 201043139 Mixture component 1 Component 2 B-lll An individualized compound I, II or IV N-((5-bromo-3-chloro-.pyridin-2-yl)-methyl)-2 ,4-Dichloro_final amine A-II-II An individualized compound I, II or IV Bremer B-113 An individualized compound I, II or IV Cypro B-114 An individualized compound I, II Or IV gas forest B-115 an individualized compound I, II or IV fenrimyl B-116 an individualized compound I, II or IV Furui comprehensive B-117 an individualized compound I, II or IV B-118 An individualized compound I, II or IV anhydropyridine B-119 an individualized compound I, II or IV Nymimo B-120 An individualized compound I, II or IV Pimenic B-121 An individualization Compound I, II or IV Safranine B-122 An individualized compound I, II or IV Seed dressing B-123 An individualized compound I, II or IV 护宁B-124 An individualized compound I, II or IV Adoniline B-125 An individualized compound I, II or IV carbendazim B-126 An individualized compound I, II or IV carbendazim B-127 An individualized compound I, II or IV Fenford B-128 An individualized compound I, II or IV Sanden B-129 An individualized compound I, II or IV Benzene bite B-130 An individualized compound I, II or IV ° sedge B -131 An individualized compound I, II or IV Isoprofen B-132 An individualized compound I, II or IV Fighting N-B-133 An individualized compound I, II or IV Free Kein B-134 An individualized compound I, II or IV singly with B-135 an individualized compound I, II or IV sputum ketone B-136 an individualized compound I, II or IV Futinib B-137 an individualized compound I, II Or IV octyl ketone B-138 an individualized compound I, II or IV chilling heat B-139 an individualized compound I, II or IV 5 -amino-2-isopropyl-4-o-phenylene phenyl-2 ,3-Diazin-pyrazole-1·S-allyl ester of thioformic acid B-140 An individualized compound I, hydrazine or IV acidified benzothiadiazole-S-methyl ester B-141 An individualized compound I , II or IV carbazolam bromide B-142 an individualized compound I, II or rv carbendazim B-143 an individualized compound I, II or IV poliomycin B-144 an individualized compound I II or IV Tetrachlorin B-145 An individualized compound I, II or IV Captan B-146 An individualized compound I, II or IV 瞒 瞒 B B-147 An individualized compound I, II or IV B-148 An individualized compound I, II or IV 15 militaris B-149 an individualized compound I, II or IV chlorpyrifos B-150 an individualized compound I, II or IV Individualized compound I, II or IV sulfhydryl sulfate wild swallow 147475. Doc -136- 201043139 Mixture Component 1 Component 2 B-152 An individualized compound I, hydrazine or IV cyanamide B-153 An individualized compound I, II or IV Forbes B-154 An individualized compound I , II or IV Oxolins Sure B-155 An individualized compound I, hydrazine or IV powder disease B-156 An individualized compound I, π or IV Puccinaz B-157 An individualized compound I , II or IV 百 隆 __ B-158 an individualized compound I, hydrazine or IV veprofen B-159 an individualized compound I, II or IV imidazoline B-160 an individualized compound I &gt; II or IV Tribendazole B-161 An individualized compound I, II or IV 2-butoxy-6-moth-3-propyl-benzo-4-one B-162 An individualized compound I, II or IV 5_ Gas-1-(4,6-dimethoxy-chito-2_yl)_2-methyl-1H-benzoimidazole B-163 an individualized compound I, II or IV 5-chloro-7-( 4-methyl-π chen-1-yl)_6-(2,4,6-trifluoro-phenyl)-[1,2,4]tris-[l,5-al ringing B-164 An individualized compound I, II or IV 5 · ethyl _ 6 · octyl-[I, 2, 4] tris-[1,5-a]°® -7-ylamine B-165 Compound I, II or rv Family B-166 An individualized compound I, II or IV Zinc Manganese B-167 An individualized compound I, II or IV Manganese B-168 An individualized compound I, II Or IV Weibai B-169 an individualized compound I, II or IV sulfacarbin B-170 an individualized compound I, II or IV free of rot B-171 an individualized compound I, II or IV methyl zinc Pu B-172 An individualized compound I, II or IV Dean B-173 An individualized compound I, II or IV Zinc Napo B-174 An individualized compound I, II or IV Yisui B-175 An individualization Compound I, II or IV Ethylbutabol B-176 An individualized compound I, II or IV Bethicillin B-177 An individualized compound I, II or IV Anthraquinone B-178 An individualized compound I, II Or IV propamocarb B-179 an individualized compound I, II or IV downyzil hydrochloride B-180 an individualized compound I, II or IV Waffenella B-181 an individualized compound I, II or IV N_(l -(1 -(4-Cyanophenyl)6-alkylsulfonyl)-butyl-J)-aminomethyl S- complex-(4-fluorophenyl) ester B-182 Was I, II or IV efavirenz B-183 a discretionary compounds I, II or IV efavirenz free base B-184 one kind of individual compounds I, II or IV guazatine.   B-185 An individualized compound I, II or IV biguanide salt - B-186 An individualized compound I, II or IV Bis-octylamine B-187 An individualized compound I, II or IV diammonium diacetate - B -188 An individualized compound I, II or IV (alkyl stearic acid) bis-octylamine B-189 An individualized compound I, II or IV Xisinmycin ___ B-190 An individualized compound I, II Or IV hydrated citric acid hydrochloride -137- 147475. Doc 201043139 Mixture Component 1 Component 2 B-191 An Individualized Compound I, II or IV Polyoxin B-192 An Individualized Compound I, II or IV Streptomycin B-193 An Individualized Compound I, II Or IV Aminomycin A B-194 An individualized compound I, II or IV Baikeke B-195 An individualized compound I, II or IV Dicloran B-196 An individualized compound I, II or IV 消螨通 B-197 An individualized compound I, II or IV 白克克 B-198 An individualized compound I, II or IV Nitrothal-isopropyl B-199 An individualized compound I, II or IV Tetranitrobenzene B-200 An individualized compound I, II or IV Triphenyltin salt B-201 An individualized compound I, II or IV Nitrile sulfonium B-202 An individualized compound I, II or IV Ling B-203 An individualized compound I, II or IV Pleurotus ostreatus B-204 An individualized compound I, II or IV Forsythia, Fossex aluminum B-205 An individualized compound I, II or IV propyl喜乐松 B-206 An individualized compound I, II or IV sub-filled Sman (H3PO3) and derivative B-207 Compound I, II or IV White Pine B-208 An Individualized Compound I, II or IV Dexamethasone B-209 An Individualized Compound I, II or IV Tetraisophthalonitrile B-210 An Individualized Compound I, II or IV Yifaling B-211 An individualized compound I, II or IV Dichlorophenol B-212 An individualized compound I, II or IV Sulfasamine B-213 An individualized compound I, II or IV hexabenzene B-214 An individualized compound I, II or IV Bin clone B-215 An individualized compound I, II or IV Pentaphenol and salt B-216 An individualized compound I, II or IV Thermos B-217 Individualized compound I, II or IV five gas nitrobenzene B-218 an individualized compound I, II or IV thiol polybutanyl B-219 an individualized compound I, II or IV methyl valproate B-220 Individualized compound I, II or IV N-(4-milo-2-nitro-phenyl)-N-ethyl-4-mercapto-benzenesulfonamide B-221 An individualized compound I, II or IV Bodo Mix B-222 An Individualized Compound I, II or IV Copper B-223 An Individualized Compound I, II or IV Copper Hydroxide B-224 - Individualized Compound I , II or IV Copper oxychloride B-225 An individualized compound I, II or IV Basic copper sulphate B-226 An individualized compound I, II or IV sulphur B-227 An individualized compound I, II or IV biphenyl B-228 An individualized compound I, II or IV bromide B-229 an individualized compound I, II or IV cycloflufen B-230 an individualized compound I, II or IV gram B-231 an individual Compound I, II or IV Diphenylamine B-232 An individualized compound I, II or IV annihilation morning 147475. Doc •138- 201043139 Mixture Component 1 Component 2 B-233 An Individualized Compound I, II or IV Dymphalin B-234 An Individualized Compound I, II or IV Quicken B-235 An Individualized Compound I, II or IV calcium cyclate B-236 an individualized compound I, II or IV spirooxamine B-237 an individualized compound I, II or IV methyl valproate B-238 an individualized compound I, II or IV N-(Mercaptopropyloxyimino-(6-difluoromethoxy-2,3-di-I-phenyl)-methyl)-2-phenylacetamidamine B-239 An individualized compound I, II or IV NH4-(4-chloro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-indenyl脒B-240 An individualized compound I, II or IV 1 Ν·-(4-(4-fluoro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-fluorene -ethyl-indole-methylformamidine B-241 an individualized compound I, II or IV Ν'-(2-mercapto-5-trifluoromethyl-4-(3-tridecyl)-alkyl- Propoxy)-phenyl)-N-ethyl-N-mercaptomethylhydrazine B-242 An individualized compound I, II or IV N'-(5-difluoromethyl-2-methyl-4- (3-trimethyldecyl-propoxy)-phenyl)-N-ethyl-N-methyl Hyperthyroid B-243 An individualized compound I, II or IV 2-{1-[2-(5-methyl-3-trifluoromethyl-inden-1-yl)-ethenyl]-purine O--4-yl}-indole-4-decanoic acid methyl-(1,2,3,4-tetrahydroqin-1-yl)-bristamine B-244 an individualized compound I, II or IV 2 -{1-[2-(5-Methyl-3-trifluoromethyl-pyrazol-1-yl)-ethinyl]-piperidin-4-yl}-thiazole-4-carboxylic acid thiol-( R)-l,2,3,4-tetrahydronaphthalen-1-yl-decylamine B-245 An individualized compound I, II or IV 6-tert-butyl-8-fluoro-2,3-diacetic acid Methyl-indol-4-yl ester B-246 an individualized compound I, II or IV methoxy-acetic acid 6-tert-butyl-8-fluoro-2,3-dimethyl-quinoline-4 -Base ester B-247 An individualized compound I, II or IV plus Poly B-248 An individualized compound I, II or IV plus Bao B-249 An individualized compound I, II or IV butyl plus Bao B -250 An individualized compound I, II or IV Nathomylthiodicarb B-251 An individualized compound I, II or IV Bifenin B-252 An individualized compound I, II or IV Sai Fanning B- 253 An individualized compound I, II or IV Sai Ning B-254 An individualized Substance I, II or IV Sub-Ning B-255 An individualized compound I, II or IV ξ-赛宁宁 B-256 An individualized compound I, II or IV Difenin B-257 An individualized compound I, II or IV 益化利 B-258 An individualized compound I, II or IV λ-赛洛宁 B-259 An individualized compound I, II or IV Baisinning B-260 An individualized compound I, II or IV Tefluthrin B-261 An individualized compound I, II or IV Fufulon B-262 An individualized compound I, II or IV Qifenlong B-263 An individualized compound I, II or IV Ruffin B -264 An individualized compound I, II or IV Defolon 147475. Doc •139· 201043139 Mixture Component 1 Component 2 B-265 An Individualized Compound I, II or IV Spirotetraethyl Ester B-266 An Individualized Compound I, II or IV Cotinide B-267 An Individualized Compound I, Π or IV 达特南 B-268 An individualized compound I, Π or IV 达达amine B-269 An individualized compound I, II or IV 赛速安 B-270 An individualized compound I, II or IV亚灭培B-271 An individualized compound I, II or IV Sai Bai B-272 An individualized compound I, II or IV Anthony B-273 An individualized compound I, II or IV Fenpney B- 274 An individualized compound I, hydrazine or IV Abatine B-275 An individualized compound I, II or IV Inhibitor B-276 An individualized compound I, II or IV Anoxin B-277 An individual compound I, II or IV Spintolan B-278 An individualized compound I, hydrazine or IV Amesson B-279 An individualized compound I, hydrazine or IV kefanita B-280 An individualized compound I, II or IV Fenbuxet B-281 An individualized compound I, π or rv Indek B-282 An individualized compound I, hydrazine or IV Flurfluent sinensis B-283 An individualized compound I, II or IV Cyclosamine B-284 An individualized compound I, II or IV flufenamide B-285 An individualized compound I, hydrazine or IV gram B-286 An individualized compound I, II or IV 赛培(HGW86) B-287 An individualized compound I, II or IV Butylated fluoro ester B-288 An individualized compound I, π or rv acetochlor B- 289 An individualized compound I, II or IV oxacin B-290 an individualized compound I, hydrazine or IV chlorpyrifos B-291 an individualized compound I, hydrazine or IV chlorpyrifos B-292 an individualized compound I , II or IV glyphosate B-293 an individualized compound I, II or IV glufosinate B-294 an individualized compound I, II or rv oxathiophosphine B-295 an individualized compound I, II or IV alkyne Oxalic acid B-296 an individualized compound I, II or IV 01 oxazole oxacillin B-297 an individualized compound I, hydrazine or IV fluazifop-butyl B-298 an individualized compound I, II or IV ° An individualized compound I, hydrazine or IV paraquat B-300 an individualized compound I, II or IV beet Ning B-301 An individualized compound I, II or IV ketene B-302 An individualized compound I, hydrazine or IV Cycloheximide B-303 An individualized compound I, II or IV Cyclopentanone B-304 An individualized compound I, II or IV chlorpyrifos B-305 an individualized compound I, II or IV from chlorpyrifos B-306 an individualized compound I, hydrazine or IV bismuthine B-307 Compound I, hydrazine or IV aniline 147475. Doc -140- 201043139 Mixture component 1 Component 2 B-308 An individualized compound I, II or IV Trifluralin B-309 An individualized compound I, II or IV Acifluorfen B-310 An individualization Compound I, II or IV bromoxynil B-311 An individualized compound I, II or IV Imazethin B-312 An individualized compound I, II or IV Amphetamine B-313 An individualized compound I, II or IV methyl imazethapyr B-314 an individualized compound I, II or IV taste 0 sitting in acid B-315 an individualized compound I, II or IV ° ° ° 啥 啥 acid B-316 an individualization Compound I, II or IV Imidazoic acid B-317 An individualized compound I, II or IV 2,4-diphenoxyacetic acid (2,4-D) B-318 An individualized compound I, II or IV Chlorophyll Min B-319 An individualized compound I, II or IV 克草特特 B-320 An individualized compound I, II or IV Fluroxypyr B-321 An individualized compound I, II or IV chlorpyrifos B-322 Individualized compound I, II or IV fluroxypyramine B-323 an individualized compound I, II or IV bensulfuron-B-324 an individualized compound I II or IV Qisulfuron-B-325 An individualized compound I, II or IV Cyclopropsulfuron-B-326 An individualized compound I, II or IV Iodomethylsulfuron B-327 An individualized compound I, II Or IV Sulfonamide B-328 An Individualized Compound I, II or IV Methsulfuron B-329 An Individualized Compound I, II or IV Nicosulfuron B-330 An Individualized Compound I, II or IV Sulfone Sulfoxsulfuron B-331 An individualized compound I, II or IV flucarbazone B-332 An individualized compound I, II or IV Astragalus B-333 An individualized compound I, II or IV hexazinone B -334 An individualized compound I, II or IV diuron B-335 an individualized compound I, II or IV diflufenacil B-336 an individualized compound I, II or IV profenofin B-337 Individualized compound I, II or IV Bentazon B-338 An individualized compound I, II or IV α 丨 ketone vinegar B-339 An individualized compound I, II or IV Cycloheptyl B-340 Individualized compound I, II or IV dicamba B-341 an individualized compound I, II or IV diflupiron B-342 an individualized combination I, II or IV Dioxin 01 Linic acid B-343 An individualized compound I, II or IV Oxalic acid B-344 An individualized compound I, II or IV Sulfosone B-345 An individualized compound I, II Or IV pyrimidine ether B-346 an individualized compound I, II or IV Topan is known as the active substance of component 2, its preparation and its resistance to harmful fungi 147475. Doc • 141- 201043139 Activity (Reference: http://www. Alanwood. Net/pesticides/); these materials are commercially available. Compounds described by the IUPAC nomenclature, their preparation and their fungicidal activity are also known (see Can.  J_ Plant Sci.  48(6), 587-94, 1968; EP-A 141 3 17; EP-A 1 52 03 1 ; EP-A 226 917 ; EP-A 243 970 ; EP-A 256 503 ; EP-A 428 941 ; EP-A 532 022; EP-A 1 028 125; EP-A 1 035 122; EP-A 1 201 648; EP-A 1 122 244 &gt; JP 2002316902; DE 19650197; DE 10021412; DE 102005009458; US 3,296,272; US 3,325,503; WO 98/46608; WO 99/14187; WO 99/24413; WO 99/27783; WO 00/29404; WO 00/46148; WO 00/65913; WO 01/54501; WO 01/56358; WO 02/40431; WO 03/10149; WO 03/11853; WO 03/14103; WO 03/16286; WO 03/53145; WO 03/61388; WO 03/66609; WO 03/74491; WO 04 WO 04/83193; WO 05/120234; WO 05/123689; WO 05/123690; WO 05/63721; WO 05/87772; WO 05/87773; WO 06/15866; WO 06/87325; WO 07/82098; WO 07/90624) ° A mixture of active substances can be prepared in a conventional manner, for example by means of a combination of the compounds I, II and/or IV, in addition to the active ingredient. Also included to A composition of an inert ingredient. With regard to the common ingredients of such compositions, reference is made to the description given for compositions containing compounds I, II and/or IV. As the compounds of the formulae I, II and IV, mixtures of the active substances according to the invention are suitable as fungicides. It is known for its outstanding utility against a wide range of phytopathogenic fungi, especially from the Ascomycetes, 147475. Doc -142- 201043139 Subspecies, deuteromycetes and downy mildew (four) (5) (4). Further, reference is made to the description of the fungicidal activity of the compound and the composition containing the compound I and the calendar / (4), respectively. .  Another aspect of the invention relates to a seed comprising at least one of formula I, hydrazine and/or ... compounds per g of 10 kg of seed. Compounds 11 and 1V and their pharmaceutically acceptable salts are also suitable for the treatment of diseases in humans and animals (especially as antifungal agents), for the treatment of cancer &amp; treatment of viral infections. The term "anti-counter" as used in the term "fungicide" refers to a drug that is resistant to animal pathogenic or human pathogenic fungi, i.e., against fungi in animals, particularly mammals and birds. Thus, another aspect of the invention pertains to a medicament comprising at least one compound of formula I, II and/or IV and/or at least one pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Suitable pharmaceutically acceptable salts are, in particular, the physiologically tolerated salts of the compounds π &amp; / or 1 'specifically, the phthalic acid addition salts formed with physiologically acceptable acids. Examples of suitable organic and inorganic acids are hydrochloric acid, hydrobromic acid, phosphoric acid, &amp; C^C:4 alkylsulfonic acid (such as methanesulfonic acid), aromatic sulfonic acids (such as benzenesulfonic acid and toluenesulfonic acid). , oxalic acid, maleic acid, transbutene-diacid, lactic acid, tartaric acid, adipic acid and benzoic acid. Other suitable acids are described, for example, in Fortschritte der Arzneimittelforschung, Vol. 1, pp. 224 et seq., in Birkhauser Verlag, Bas. 6 and in 1966, the entire contents of which are hereby incorporated by reference. Suitable carriers are, for example, solvents, carriers, excipients, binders, and the like which are commonly used in pharmaceutical formulations, exemplified by the individual dosage forms 147475. Doc -143 - 201043139 The formula is described. Another aspect of the invention relates to the use of the compounds I, II and IV or their pharmaceutically acceptable salts for the preparation of antifungal agents; that is, for the preparation of a therapeutic and/or prophylactic human pathogenic and/or animal pathogen. Use of drugs for fungal infections. Another aspect of the invention is the use of a compound of formula I, II and/or IV, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment of cancer. Another aspect of the invention is the use of a compound of formula I, π and/or IV, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment or prevention of a viral infection. The 弋I 11 and/or 1V compound and/or its pharmaceutically acceptable salt are suitable for the treatment, inhibition or control of growth and/or proliferation of tumor cells and its associated disorders. Therefore, it is suitable for treating cancer of warm-blooded vertebrates/, the warm-blooded vertebrates of the temple are, for example, mammals and bird members, specifically humans, and other mammals, specifically useful domestic animals such as dogs, L pigs, reverse animals (bovine sheep, goats, bison, etc.), horses and birds, =, turkey, hong, crane, guinea fowl and similar animals. Formula I, π and pharmaceutically and/or pharmaceutically acceptable salts thereof are suitable for: cancer or cancerous conditions of the following organs: breast, lung, intestine, prosthetic j skin (melanoma), kidney 'bladder, Mouth, throat, esophagus, stomach, nest, pancreas, liver and brain or CNS. Month 1! The compound and 'or its pharmaceutically acceptable salt are suitable for::: viral infection of blood vertebrates'. The isothermal gold vertebrates, such as self-cultivating animals and birds, are specifically stated as Useful livestock, such as dogs and other mammals, vegetable sticks, pigs, anti-dance animals (bovine, flat, goat, bison, etc.), horses and birds, such as chicken, turkey, duck, 147475. Doc • 144- 201043139 Cranes, guinea fowls and similar animals. It is suitable for the treatment of viral infections such as retroviral infections (such as HIV and HTLV), influenza virus infections, rhinovirus infections, herpes and the like. The compounds of the invention may be administered in a conventional manner, for example, orally, intravenously, intramuscularly or subcutaneously. For oral administration, the active compound can be mixed, for example, with an inert diluent or with an edible carrier; it can be enclosed in a hard gelatin capsule or a soft gelatin capsule, which can be compressed into a tablet or can be directly Mix with chyme/feed. The active compound may be mixed with excipients and administered in the form of non-digestible lozenges, troches, tablets, pills, capsules, suspensions, liquids, syrups and the like. The composition of such preparations which should contain at least 〇丨% of the active δ-formulation may of course vary. It typically comprises from 2% to 6% by weight, based on the total weight of the formulation (dosing unit) in question, of the active compound. Preferred formulations of Compound I of the present invention comprise from 1 to 1000 mg of active compound per oral dosage unit. Tablets, tablets, pills, capsules and the like may additionally comprise the following group of ingredients: a binder such as tragacanth, gum arabic, corn starch or gelatin; an excipient such as dicalcium phosphate; Disintegrating agents, such as corn house powder, potato powder, alginic acid and the like; slip agents such as magnesium stearate; sweeteners such as sucrose, lactose or saccharin; and/or spices, such as pepper Mint, vanilla and the like. The capsule may additionally comprise a liquid carrier. Other substances that modify the characteristics of the dosage unit can also be used. For example, lozenges, pills and capsules may be coated with schellack, sugar or mixtures thereof. In addition to the active compound, the sugar or drink may also contain sugar (or other sweetener), thiol benzoic acid or p-tetracarboxylic propyl vinegar (for 147475. Doc -145- 201043139 For square rot, coloring agents and/or fragrances. The components of the active compound formulation, when used in amounts, must be pharmaceutically pure and non-toxic. In addition, the active ingredient can be formulated as a controlled release active compound, for example, as a delayed release formulation. The active compound can also be administered parenterally or intraperitoneally. A solution or suspension of the active compound or a salt thereof can be prepared in water using a suitable wetting agent such as hydroxypropylcellulose. Glycerin, liquid polyethylene glycol, and mixtures thereof can also be used to prepare dispersions in oil. These formulations often additionally contain a preservative to prevent microbial growth. The preparation to be used for injection contains a sterile aqueous solution and dispersion, and a sterile powder for the preparation of a sterile solution and dispersion. The formulation must be sufficiently liquefied to be injected more. It must be stable under the conditions of manufacture and storage and must be kept shy to prevent microbial contamination. The carrier can be a solvent or dispersion medium such as jc ethanol &amp; alcohol (e.g., glycerol, propylene glycol or liquid polyethylene glycol), mixtures thereof and/or vegetable oils. [Embodiment] The present invention is further illustrated by the following non-limiting examples. I. Synthesis Example 1·Preparation of 5-(2-three gas, methicillin, sulfenyl)-1-(5-fluorenyl-[1,2,4]-triazol-1-ylmethyl)-2 , 2-dimercaptocyclopentanol [. (2 -fluorononylphenyl)_methyl-(£)_subunit]_2,2-didecylcyclopentanone to 2,2-dimethylcyclopentanone 〇〇g, 44 cooled at C 57 匪〇1) and 2—three gas methyl benzoic acid (6. 97g, 49. 03 mm. (10) Ethanol (9) A solution of (10) aqueous sodium hydroxide (9 mL) was slowly added to the solution. Make 147475. Doc • 146· 201043139 The reaction mixture was allowed to warm to room temperature and stirring was continued overnight. The mixture was concentrated in vacuo and dioxane (100 mL) was added. The aqueous phase was acidified with hydrochloric acid and the phases were separated. The aqueous phase was extracted with di-methane (2 x 100 mL) and the combined organic extracts dried over magnesium sulfate. The solvent was removed under reduced pressure to give the title product (11. 30 g, 41. 89 mmol, 94%). 1·2 5-(2-dihydroquinone basic methyl)-2,2-dimethylcyclopentanyl as the compound obtained in Example 1_1 (11. 90 g, 44. 36 mmol) was dissolved in hydrazine tetrahydrofuran (110 mL) and reduced under ambient hydrogenation conditions in the presence of Raney-Nickel (10% mmol) at ambient temperature overnight. The reaction mixture was filtered through EtOAc (EtOAc)EtOAc. The filtrate was concentrated under reduced pressure to give the title product (75. 75 mmol, 62%). 1. 3 5-(2-Trifluoromethylphenylindenyl)_2,2-didecyltriazole-b-methyl-cyclopentanol to sodium hydride (2. 33 g, 97. 9 mmol) of N-decylpyrrolidone (35 ❹ mL) was slowly added with cesium iodide (9. 16 g, 4l. 62 mmol). When the foaming stops, add hydrazine, 2,4]-1 Η-triazole (3. 83 g, 55. 50 mm 〇 1) and continue to stir for another 3 minutes. Next, add instance 1. The sigma obtained in 2 (7. 50 g ’ 27. 75 mmol), followed by the addition of isopropanol (35 mL) and heating the mixture. After completion of the reaction, water (1 〇〇 mL) was added followed by the addition of methyl I butyl ether (250 mL) and a chlorinated chain (1-2 scoop). The phases were separated and the aqueous phase was washed with methyl tert-butyl ether (2 x 100 mL). The combined extracts were washed with water (3×50 mL) and dried over magnesium sulfate. The residue was purified using flash chromatography to give the title 147475. Doc -147- 201043139 Product (2. 45 g, 6. 94 mmol, 25%). 1. 4- 5-(2-Trifluoromethylphenylindenyl)_i_(5-fluorenyl_[12,4]triazole-indolyl)-2,2-dimethylcyclopentanol To Example 1. Addition of elemental sulfur (〇345 g, ι415 mmol) to a solution of the compound obtained in 3 (〇5〇g, 1 41 mmol) in N-decylpyrrolidone (15 mL) at 180 ° C The mixture was heated overnight. After cooling to room temperature, hydrazino dibutyl ether (50 mL) was added and the mixture was filtered through a short celite pad. Under reduced pressure, the liquid was filtered, and an aqueous solution of a gasification clock (20 mL) was added to the residue. The aqueous phase was washed with ethyl acetate (3×5 mL), and the combined organic extracts were washed with EtOAc (3×10 mL). The mixture was concentrated in vacuo and the residue was purified eluting elut 16 g, 〇_42 mmol, 30%;). HPLC-MS residence time (mass): 3 542 min (386) The compounds of Examples 2 and 3 were prepared analogously. 2.  5-(2-Fluorobenzyl)indenyl_[12 4]-triazolylhydrazyl)_2,2_didecylcyclopentanol HPLC-MS retention time (mass): 3 274 min (336) 3_ 5_ (2. fluorochlorobenzyl)-1-(5-fluorenyl-[1,2,4]-triazol-1-ylindenyl)_ 2,2-dimercaptocyclopentanol HPLC-MS residence time (Quality): 3 477 min (352) Π. Examples of the action against harmful fungi The fungicidal action of the compounds of the formulae I and II is demonstrated by the following experiments: A) Greenhouse test The active substances are separately or together formulated into a reservoir containing 25 mg of active substance. Doc -148- 201043139 Preparation of a solution using acetone and / or dimethyl sulfoxide (DMS 〇) mixture and emulsifier ttol EM 3 1 (wet shoulder with emulsification and dispersion based on ethoxylated base age) The solution was prepared to 1 G W with a solvent/emulsifier volume of 991. ^ Then use water to make up the solution to 1 〇〇 ml. The stock solution was diluted with the dissolved J / emulsifier / water mixture to the active substance concentration given below. Use example 1: The cure effect of cockroaches on soybeans caused by soybean rust bacteria Ο

The leaves of potted soybean seedlings were inoculated with a spore suspension of large rust (soybean rust). The plants were then placed in a chamber with a high atmospheric humidity (9〇% to 95%) and a temperature of 20-24t for 24 hours. During this time, the spores germinate and the germ cells penetrate into the leaf tissue. The test plants were then incubated in a greenhouse at a temperature between 23 and 27 t and a relative atmospheric humidity of 60 to 80%. Two days later, the plants were sprayed to the overflow point (runoff p〇int) with the above aqueous solution having the following active substance concentration. After drying the suspension, the temperature is at 23. The plants were incubated for another 1 day in a greenhouse between 〇 and 27 and at a relative atmospheric humidity of 60% to 80%. The degree of rust development on the leaves was then visually determined. Active compound concentration [ppm] Star length [%1 - (control group) 70 Example 1 300 0 Example 2 300 0 Example 3 300 Use example 2. For the case of the genus Septoria spp. caused by the wheat sphaeroides Protection The potted wheat seeds 147475.doc - 149 - 201043139 field leaves were sprayed to the overflow point with an aqueous suspension having the following active substance concentrations. 24 hours after the suspension was dried, the treated plants were inoculated with a spore suspension of S. cerevisiae. The plants were then placed in a chamber with a high atmospheric humidity (about 100%) and a temperature of 18 hunger for 4 days, and then placed at a relatively large milk fullness of about 70% and a temperature of 18-22. After the day in the chamber of the cockroach, the degree of rust on the leaf f 1 Λ + ^ was visually determined and expressed as a percentage of the surface of the occupant. T1111 leaf active compound: control group) ¥5ϊ3

Growth [%] 90~ Ί〇~~

147475.doc -150-

Claims (1)

201043139 VII. Patent application scope: 1. The three salivation compounds of formula I and formula II, L1 and L4 are independently selected from hydrogen, fluorine, bromine, iodine, and (iv). A thiol group, a Cl_ClGi alkyl group, a 'Cl-CiQ methoxy group, and a CVC1 () halogen alkoxy group; and L and L3 are independently selected from the group consisting of hydrogen, sulfhydryl, and Ci_Ci. Burning base, LG. The base of the tooth, Cl_Cl to oxy group and. Self-activating oxy; limiting condition is that at least one of L1, L2, L, L4 is not nitrogen; 〇R1 and R2 are independently selected from hydrogen, Ci_Ci fluorene, Ci-Ci 〇, C1-C10 Alkoxy and (^-(:10 haloalkoxy; R is selected from the group consisting of hydrogen, Cl_Ci 〇 alkyl, widely. Haloalkyl, Ci_Ci decyloxy and Ci-C10 haloalkoxy; R system Selected from hydrogen, Cl_ClG alkyl, Ci_CiG_alkyl, C2_Ci-decenyl, C2-C1G-alkenyl, c2_CiG fast radical, c2_Ci. Halo fast radical, c3_Ci〇 cycloalkyl, C3_C1 (cycloalkyl, phenyl) a phenyl-C1_C4 alkyl group, wherein the phenyl moiety in the last two mentioned groups may have 1, 2, 3, 4 or 5 substituent bases 8, and contain 1, 2 or 3 selected from N a hetero atom of 0 and S as 147475.doc 201043139 is a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring of a 5 member, wherein the heterocyclic ring may have i, 2 or 3 substituents R8; In the case where η is 〇, it may also be selected from the group consisting of C(= 〇)R5, _C(=S)R5, _s(〇)2R5, CN, -P(=Q)R6R7, M and a group of formula m, L], L·2, L·3, L4, R1, R2 and R3 are as defined in the formula [and π where # is the point of attachment to the rest of the molecule; R4a is selected from hydrogen, (VCm alkyl, (^-(:10 haloalkyl, c2_Cl0 alkenyl, C2-C丨〇 haloalkenyl, C2-C10 alkynyl, C2-C10 haloalkynyl, c3-Ci〇cyclohexyl, 6-(:10 halo) a cycloalkyl, phenyl, phenyl-Cl_c4 alkyl group, wherein the phenyl moiety in the last two mentioned groups may have 1, 2, 3, 4 or 5 substituents R8' containing i, 2 or 3 a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring selected from the group consisting of a hetero atom of N, hydrazine and S as a ring member, wherein the heterocyclic ring may have 1, 2 or 3 substituents R8, -C ( =0) R5, _C(=s)R5, -S(〇)2R5, -CN, -P(=Q)R6R7 and Μ; R5 is selected from hydrogen, (Vq❶ alkyl, alkyl, Cl-c1 ( Alkoxy, Ci-Cio halooxy, (^-(210-aminoalkyl) (33-匚10cyclodecyl, 147475.doc -2- 201043139 〇3_〇: 10-halocycloalkyl, Phenyl, phenyl-Ci_C4 alkyl, phenoxy, wherein the phenyl moiety of the last three mentioned groups may have 1, 2, 3, 4 or 5 substituent bases 8, containing 1, 2 or 3 out of N, Ο a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring of a hetero atom of S, wherein the heterocyclic ring may have 1, 2 or 3 substituents R8, and NR9R10; R6 and R7 are independently selected from each other. From Cl-ClQ alkyl, Ci_Cig_alkyl, c2-c1Q dilute, c2_ClG haloalkenyl, C2_CiG alkynyl, c2_Ci decyl alkynyl, c3-c1Q ring, C3_ClG halocyclo, Ci_Ci 〇 oxy , cvcw tooth alkoxy, Ci-C4 alkoxy _Ci_Ci oxime, Ci_C4 alkoxy-CVCw alkoxy, Cl_ClG thiol, Ci_Ci()i thio, Cy Cio dioxy, C2- C1G thiol, c2-C1Q alkynyloxy, C2-C1Q alkynylthio, C3_C1()-cycloalkoxy, C3_C1G cycloalkylthio, phenyl, phenyl_q-C4 alkyl, phenoxy, a phenylthio group, a phenyl-Ci_C4 alkoxy group and NRnR12; each R8 is independently selected from the group consisting of halogen, nitro, CN, Ci_C4 alkyl, Ci_C4 haloalkyl, 0^-(:4 alkoxy, Ci-C^ a halogen alkoxy group and NR13R14; R9 is selected from hydrogen and c--c8 alkyl; R10 is selected from hydrogen, Ci-C8 alkyl, phenyl and phenyl-Ci_C4 alkyl; or R9 forms a straight line with R1G Chain C4 or 〇5 stretch alkyl bridge or group -CH2CH2OCH2CH2- or -CH2CH2NR15CH2CH2-; R&q Uot; is selected from the group consisting of hydrazine and CVCs alkyl; R12 is selected from the group consisting of hydrogen, c^-c:8 alkyl, strepyl and phenyl-Ci_c4 alkyl; or R11 and R12 together form a straight chain C: 4 or ( ^alkylene bridge or group -CH2CH2OCH2CH2- or -CH2CH2NR15CH2CH2·; 147475.doc 201043139 Rl3 is independently selected from hydrogen and alkyl at each occurrence; phenyl and RM are independently selected from each occurrence , Cl-C8 alkylphenyl-CVC4 alkyl; or R and 11" to form a direct bond ^ or ^ stretch-base bridge or group ^ 2 Η 2 Η 2 〇〇Η 2 € Η 2-^ -CH2CH2NR15CH2CH2-; R15 Each occurrence is independently selected from the group consisting of a gas ACi_C4 alkyl; Q is 0 or S; Μ is a metal cation equivalent or an ammonium cation of the formula (NRaRbRcRd)+, wherein Ra, Rb, ... and Rd are independently selected from hydrogen An alkyl group, a phenyl group, and a stupid methyl group, wherein the phenyl 4 knives in the last two mentioned groups may have an anthracene, 2 or 3 substituents independently selected from the group consisting of halogen, CN, an exact group, Ci_C4 alkyl, C _C4 dentate, Ci_C4 alkoxy, C--C4 haloalkoxy and nr"Ri4; n is 〇, 1, 2 or 3; and --- is a single bond or a double bond And its agriculturally acceptable salts. 2. For the compound of formula I and formula II of claim 1, which has the formula ΙΙΑ and ΙΙΑ, R4a (ΙΑ) L2 Η iVs N-N (ΠΑ) 147475.doc 201043139 wherein R1, R2, R3, R4, R4a, L1, L2, L3, and Lin are as defined in claim 1. 3. The compound of formula i and formula π according to any of the preceding claims, wherein l2 &amp;l3 are independently of each other selected from the group consisting of hydrogen, halogen, Cl_c3 alkyl, q-Cs haloalkyl, Ci-C3 alkoxy &amp; Cl_C3 haloalkoxy. 4. The formula of claim 3 and the compound of the formula wherein L2 and L3 are independently selected from the group consisting of hydrogen, halogen, methyl, CH2F, CHF2, CF3, decyloxy, 0 〇CH2F, 〇CHF2, 2,2 2—Trifluoroethoxy, 1,1,2,2-tetrafluoroethoxy and penta-I ethoxy, preferably selected from the group consisting of hydrogen and gas. And a compound of formula II, wherein L1 and L4 are, independently of each other, selected from the group consisting of hydrogen, fluorine, bromine, CVC3 alkyl, Cl-C3 haloalkyl, ci_C3 alkoxy&amp;Cl_c3 haloalkoxy. And a compound of the formula II, wherein L1 and L4 are independently selected from the group consisting of hydrogen, fluorine, bromine, methyl, CH2F, CHF2, CF3, decyloxy, 〇CH2F, 〇CHF2, 0CF3, 2,2,2 -Trifluoroethoxy, 1,1,2,2-tetrahydrofluoroethoxy and pentafluoroethoxy. The compound of formula 1 and formula II, wherein L1 and L4 are independently selected from each other Hydrogen, fluorine, and cf3. The compound of Formula I and Formula II of any one of the claims, wherein one or both of L1, L, ', and L4 are not hydrogen. And a compound of the formula I, wherein one of L1 and L4 is not hydrogen and the other is hydrogen. A compound of formula I and formula II, wherein at least one of L2 and L3 is hydrogen. 147475.doc 201043139 11 _A compound of formula I and formula II according to claim 10, wherein L2 and L3 are both hydrogen, or one is hydrogen, and the other is a gas. The compound of formula I and the formula of any one of the preceding claims, wherein Ri and r2 are independently selected from hydrogen And a compound of the formula I and the formula II according to any one of the preceding claims, wherein the R3 is selected from the group consisting of hydrogen, methyl, and B. And a trifluoromethyl group, preferably a hydrogen. 14. A compound of formula I and formula π according to any of the preceding claims, wherein R5 is selected from the group consisting of CVC4 alkyl, Cl_C4 alkoxy, phenyl, phenoxy And nr9r1〇, wherein R9 is hydrogen, and R10 is selected from the group consisting of hydrogen, a Ci-Q alkyl group, and a phenyl group. The compound of formula I and formula II according to any one of the preceding claims, wherein R4 is selected from the group consisting of hydrogen, CVQ alkyl, _c(=〇)R5, -S(0)2R5, -CN, hydrazine, and a group of formula III. 16. The compound of formula i and formula π according to any one of claims 15 wherein R4 is selected From hydrogen, CVC4 alkyl, c3-C4 alkyl A carbonyl group, (VC4 alkoxycarbonyl, -CbCONCHKrC^alkyl, CVC4 alkylsulfonyl, CN, and a group of formula III, preferably selected from the group consisting of hydrogen, CN, and fluorenyl. 17. Any of the foregoing claims The compound of formula I and formula π, wherein is selected from the group consisting of hydrogen, CVC4 alkyl, and haloalkyl. A compound of formula I and formula II according to any of the preceding claims, wherein n is zero. 19. A compound of formula IV, 147475.doc -6- 201043139 Μ Ν~Ν’ Any one of the following; Ο except for the following compounds, where R1 ' R2 ' R3 ' L2 ' L3 ^ τ 4 ^ ^ τ 1 L and L are 虱, l1 is fluoro 'bromo, methoxy or CF3, and rrrr is double Key; and L is hydrogen, L1 is fluorine, bromine, R1 and R2 are both CH3, R3, L2, L: decyloxy or CF3' and two rr are double bonds; R1 'R2 'R3 ' L1 ^ bond. 20. A compound of the formula IVA, and L4 is hydrogen, L2 is cf3, and is mono- Ο N~N L2 Η (IVA) wherein R1, R2, R3, L1, L2 are as defined in any one of the following; except for the following compounds, wherein R1, R2, hydrogen, and L2 are CF3. L and L4 are as claimed in the claims R3, L1, 1 to 13 L3 and L4 are 147475.doc 201043139 21. The compound of the formula V, L2, L3 and L4 are as defined in any one of claims 1 to 13 wherein R1, R2, R3, L1; except for the following compounds Ri, R2, R3, L2, L3 and L4 helmet gas τ 1 Λ long L is虱, l1 is fluorine or CF3, and is a double bond; and L and L4 are fluorine, and - is R1, R2, R3, L2, and L3 are hydrogen single bonds. 22. a compound of the formula VA, Wherein R, R, 113, 1^, [2, 1^3 and 1/ are as defined in any one of claims 1 to 13; except for the following compounds wherein R1, R2, R3, and B2 are. It is hydrogen, and L1 and L4 are fluorine. 23·—Formula VI Compound, 147475.doc (VI)201043139 9H2 r3 Where Ri, R2, r3 are defined; L, l2, L3 and L4 are as in claims 1 to 13 Except for the following compounds, JL 'L1 is a desert' and 24. a compound of the formula VIA, wherein Ri, n2, and R3 are single bonds. L2, L3 and L4 are R/R3, L2, L3 and L4 are excluded from the following compounds, wherein R] Q hydrogen and L1 is bromine. 25. a compound of formula VII, , L2, L3, and L4 are as defined in any one of Ri, R2, R3, and L1 in claim u13; R14 is Η or C(〇)OR15, wherein 147475.doc -9· 201043139 e R is selected from hydrogen , Cl-Cl oxime, Ci-Cw functional base, c3-C10% alkyl C3-C!. a cyclyl, phenyl, phenyl-C1_C4 alkyl group, wherein the phenyl moiety of the last two mentioned groups may have 2, 3, 4 or 5 substituents, and contain 1, 2 or 3 heterocyclic atoms selected from N, oxime and S as a member of 5 or 6 members of a saturated, partially unsaturated or aromatic hetero 8 ring 'wherein the heterocyclic ring may have 2 or 3 substituted red 8 wherein R 8 Is as defined in claim 1; except for the following compounds, wherein R1, R2, R3, T? 14 τ 2 , . , L, L and L4 are hydrogen, and l1 is CF3 or bromine; gossip K, K/, L, T3kt4^&gt;*. L and L are hydrogen, and L2 is CF3, methoxy or fluorine; Ri, R2, R3, L1 and L4 are prepared as τ 2 , and L is 虱' L2 and L3 is a third butyl group and is hydrogen or cooch3. 26. —Formula νΙΙΗί: Compound, (VIII) "RRL, l2, l3, and L4 are as defined in any one of claims [alpha]13 and R14 is as defined in claim 122; except for the following compounds, where R1 'R3 'R14 &gt; L2 &gt; I 3 U τ 43⁄4 . , L and [is 虱, and L1 is CF3 or bromine; R1, R3, R14, L1, 4 L and 虱, and L2 is cf3, methoxy 147475.doc •10- 201043139 or Derivative; butyl, and R14 is hydrogen, R1, R3, Li and L4 are hydrogen, and are or cooch3. 27. - compound of formula IX Except for the following compounds, wherein Ri, R2, R3, RW, L2, L: ❹ and 7ΓΓ7 are single bonds; and L4 is hydrogen, L1 is CF3 or bromine, and Rl, R2, R3, RW, Ll 3 4 and L are hydrogen. , l2 is CF3, methoxy or fluorine ' and two rr is a single bond; &quot;R1, R2, R3, Li and !/ are hydrogen. and. It is a third butyl group, and r&quot; is hydrogen or COOCH3' and the diterpene is a single bond. 28. An agricultural composition comprising at least one compound of the formula I'II and/or IV and/or IVA, or an agriculturally acceptable salt thereof, as claimed in any one of the claims, and a liquid or solid carrier. 29. The use of any of the claims U20 and/or the use of the iva/ or Μ compound for the control of harmful fungi. 30. A method of controlling harmful fungi, wherein the fungus, its habitat is treated with an effective amount of at least a compound of formula and/or IV and/or IVA, or 147475.doc •11 - 201043139 31 32. 33 34. «The substance or plant, or soil or propagation material, of which the compound I, π and 1 and/or IVA are as defined in any of the claims. A seed, per HK) kg of seed, in an amount of at least a compound of formula I II and / or IV and / or IVA, wherein compound J, form ... and / or IVA is as claimed in any one of claims 1 to 2 Defined. A pharmaceutical composition comprising at least one of the compounds of formula I, II and/or IV and/or IVA, or a pharmaceutically acceptable salt thereof, as claimed in any one of the claims, and at least one pharmaceutically acceptable carrier Agent. A use of a formula, or a ... and/or an IVA pharmaceutically acceptable salt, or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 20, for the manufacture of a medicament for treating cancer or a viral infection or Used to prepare antifungal drugs. A method of treating a cancer or a viral infection or against an animal pathogenic or human pathogenic fungus, comprising at least one of the compounds of formula I, II and/or IV and/or IVA according to any one of claims 1 to 2 The individual in need thereof is treated with at least one pharmaceutically acceptable salt thereof or a pharmaceutical composition as claimed in claim 32. 147475.doc 12- 201043139 IV. Designated representative map: (1) The representative representative of the case is: (none) (2) The symbolic symbol of the representative figure is simple: 5. If there is a chemical formula in this case, please reveal the best display invention. Characteristic chemical formula: 147475.doc