TW200950769A - New material used for package for sevoflurane - Google Patents
New material used for package for sevoflurane Download PDFInfo
- Publication number
- TW200950769A TW200950769A TW97149631A TW97149631A TW200950769A TW 200950769 A TW200950769 A TW 200950769A TW 97149631 A TW97149631 A TW 97149631A TW 97149631 A TW97149631 A TW 97149631A TW 200950769 A TW200950769 A TW 200950769A
- Authority
- TW
- Taiwan
- Prior art keywords
- container
- gasket
- cover
- sevoflurane
- ethylene
- Prior art date
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
Abstract
Description
200950769 六、發明說明: 【發明所屬之技術領域】 ' . 本發明係有關由環狀烯烴高分子,以及乙烯和辛烯的 接枝共聚物構成的材科在製造用於存放麻醉劑的容器的用 途,及有關一種容器,其包括容器體和容器蓋,該: 器體的内表面的材料為由環狀烯烴共聚高分子以及乙 辛稀的接枝共聚物組合共同構成者。. 【先前技術】 . · ❹ 化合物七氟烷(Sevoflurane)[氟甲基-1,l l 3 3 3_ 六氟異丙基醚,亦即(CF〇2CH〇CH2F]是一種廣泛使用的’吸入 式麻醉劑,通常包裝在玻璃、不錄鋼容器内。但已發現在 某些情況下,七氟烷與玻璃容器會相互作用,從而促進七 氟烧的分解。這種相互作用被認為是由於七倾在路易士 酸存在之情況下會分解而產生分解產物如氫氟酸。 目前通用的玻璃材料為皿型玻璃,這種材料含有二氧 ❹化石夕、氣氧化約、氫氧化麵和氧化銘。瓜型玻璃中含有的 氧化銘直接暴露於七氟燒中時會引起路易士酸的作用,從 而促進七氟燒的分解,由這種分解反應產生的分解產物如 氫^酸會钱刻玻璃的内表面,從而使更多的氧餘暴露在 七既烧中,這樣進一步促進了七氟烧的分解,影響了產品 的使用。 人=已經做了努力,藉由採用穩定的、不易產生路易 士酸的容器來包裝七氟燒’或採用足夠量的路易士酸抑制 ^來抑制七氟&的分解’這些發明都已獲得相應的專利如200950769 VI. Description of the invention: [Technical field to which the invention pertains] The invention relates to the use of a cyclic olefin polymer, and a graft copolymer of ethylene and octene, for the manufacture of a container for storing an anesthetic agent. And a container comprising a container body and a container lid, wherein: the material of the inner surface of the body is composed of a combination of a cyclic olefin copolymer polymer and an ethyl octyl graft copolymer. [Prior Art] · ❹ Compound sevoflurane (Sevoflurane) [fluoromethyl-1,ll 3 3 3_hexafluoroisopropyl ether, ie (CF〇2CH〇CH2F] is a widely used 'inhalation type Anesthetics, usually packaged in glass, stainless steel containers, but it has been found that in some cases, sevoflurane interacts with glass containers to promote the decomposition of heptafluorocarbon. This interaction is thought to be due to seven tilts. In the presence of Lewis acid, it will decompose to produce decomposition products such as hydrofluoric acid. Currently, the common glass material is glass-type glass, which contains dioxin fossil, gas oxidation, hydroxide surface and oxidation. The oxidation of the cucurbit-type glass contained in the hexafluoride will cause the effect of Lewis acid when it is directly exposed to heptafluorocarbon, thereby promoting the decomposition of heptafluorocarbon. The decomposition products such as hydrogen acid generated by this decomposition reaction will be engraved with glass. The inner surface, so that more oxygen is exposed to the seven burns, which further promotes the decomposition of heptafluorocarbon, which affects the use of the product. People = have made efforts by using stable, not easy to produce Lewis acid Packaging container heptafluoro burn 'or Lewis acid employed is an amount sufficient to inhibit the suppression heptafluoro ^ & exploded' These have been given corresponding patent disclosure as
I 3 94584 200950769 CN 1152674C 和 CN llTfiRiRr1 # 丄 聚乙烯萘㈣甲:聚丙其:c:117〇516c主要選擇 樹脂等材料來製成容二=定子聚合物 顯著的作用。 穩疋七减、抑制降解有 一、但是>師料不僅限於上述專利所描述的材料,隨 咼分子材料技術的不斯描古-勒成々、 者 藥口Μ來越多的高分子材料用於 樂⑽匕裝我們在上述專利所述的材.料之外也發現了一些 Ο 適宜七氟烧之包裝材料。較佳的材料是環狀烯煙共聚高^ 子(⑽,CyCl〇〇lefin c〇p〇lymer),這種材料不含可促進 七敦烧分,㈣,料種㈣製絲賴存七氣 烧,不需添加路易士酸抑制劑來抑制七氟烧的分解。 環狀烯烴共聚高分子⑽)是泰_(Ti_)公司開 發出來的’其商品名為TGPAS,是具有環狀烯烴結構的非 晶性透明共聚高分子。環狀烯烴共聚物屬於無定型熱塑工 程塑料的一個新系列產品,具有很高的透明度、濕氣阻隔 ❹性、熱變型 /皿度(HDT ’ Heat Deflection Temperature)、 耐化學藥品性等特點。C0C具有與PMMA(聚甲基丙烯酸甲 酯、丙烯酸樹脂)相匹敵的光學性能以及具有高於pc(聚碳 酸酯)的耐熱性’還具有比PMMA和PC更加優良的尺寸穩定 V , 性’還具有改善水蒸氣氣密性,增加剛性、耐熱性,易賦 .· ... - 予切割性能等優點。TOPAS(COC)8007品級的材料主要應用 於加工各種用於盛裝麻醉劑及藥品的瓶子,這些瓶子可經 受人們通常所採用的所有殺菌方法進行殺菌消毒、如蒸汽 消毒、乙烯氧化物消毒、電子及r-射線殺菌等,因此,環 4 94584 200950769 狀烯共聚高分子(C0C)在藥用包裝材料領域有著廣泛的 - 應用前景。相對於玻璃、不銹鋼材料而言,它不含氧化鋁、 • 氧化鐵等路易士酸,從而保證了七氟烧的儲存穩定性。 T0PAS具有很高的安全性,規格標準已獲得美國fda 認證。NamSA依據美國藥典,對TOPAS(COC)8007樣品進行 測試’在FDA的C到Η類的使用條件下,TOPAS(COC)8007 完全符合FDA的要求。 艾克森美孚(ExxonMob i 1 e)製造的 ExactTMP 1 astomers ©是乙烯與烯烴的.共聚物,其係包含丁烯、己烯、辛烯共 聚單.體在内的非常豐富的產品,它具有下列特性:傑出的 低、溫抗衝擊性;低比重;潔淨;傑出的熱封性能;與各種 基礎聚合物相容性優異;優異的柔順性與抗穿刺性;極高 的無機物填充性;優越的伸長率和高彈性;耐輻射引起的 脆化和脫色等。ExactTMPlastomers,型號:£乂八(^ 5061, 是乙烯和辛烯的接枝共聚物(ethylene alpha octene ❹ copolymers)。符合 FDA 法規:21 CFR 177. 1520 “烯烴聚 合物”(c)3. 2c,可以應用於接觸食品的原料及物品。溫度 達到熱填充或高於150°F(低於212°F)時,且在21CFR : 176. 170(c)表2中通過Η用途C條件下,烯烴聚合物物品 可以接觸CFR CFR 176. 170(c)中表1中的所有食品類型。 在我們的實施例中,還擇TOPAS(COC)8007和 ExactTMP 1 astomers (EXACT 5 0 61)製成的包裝容器保存七氟 烷。在該包裝容器中,T0PAS(⑶08007作為主要材料構成 成分,EXACT 5061作為輔助成分,目的是提高容器的抗跌 5 94584 200950769 性能。 【發明内容】 本發明係有關一種 .— 該容器材料由環狀婦煙芯產:,該產品包括:::器, 聚物構成,該容器〜二聚向分子及乙烯和辛烯的接枝共 内部的一金喜^° (疋―内部空間;以及在所限定的空間 該容器吸八麻醉劑七氟烧。 〇 Ο 器的該内壁由環内部空間相鄰的内壁’該容 聚物構成;在該哭聚馬分子及乙烯和辛烯的接枝共 烷。 :00 <定的該内部空間放入預定量的七氟 該容器限定—開口 = 呈流體連通,;5 ^ ’該開口使該内部空間和外部環境 σ 5 片,該墊片在蓋的^烯(HDPE),該蓋的内部有密封墊 材料為聚對苯二甲以與該容器中的流體接觸。墊片 泡材料。用該i有C,SI(PET)薄膜或聚乙烯(PE)發 口。以及在該容考PP〜片的蓋來密封該容器限定的該開 在本發明中°,H的該内部空間放入預定量的七氣烷。 -般瓶型,也可以的用途是盛放七氟烷,容器可以為 狀烯烴共聚高分子::他形狀和容量。已發現,採用以環 包裝容器來盛放七心及乙缔和辛稀的接枝共聚物製備的 相容性和強度特性,可’、有所期望的蒸氣阻隔性、化學 膜、趣等包裝材科。讀通用的成型加工方法製傷薄I 3 94584 200950769 CN 1152674C and CN llTfiRiRr1 # 聚乙烯 Polyethylene naphthalene (4) A: Polypropylene: c: 117 〇 516c Mainly choose materials such as resin to make a significant effect on the secondary polymer = stator polymer. There are ones that are stable and seven-reduced, and that inhibit degradation. However, the materials are not limited to the materials described in the above patents, and the more molecular materials used in the molecular materials technology, the more polymer materials are used. Yu Le (10) armored We also found some packaging materials suitable for sevoflurane in addition to the materials mentioned in the above patents. The preferred material is a cyclic olefinic copolymer high ((10), CyCl〇〇lefin c〇p〇lymer), this material does not contain the seven-burning fraction, (4), the seed (four) is made of silk Burning, do not need to add a Lewis acid inhibitor to inhibit the decomposition of heptafluorocarbon. The cyclic olefin copolymer polymer (10)) is a non-crystalline transparent copolymer polymer having a cyclic olefin structure, which is commercially available from Tai-Ti Company under the trade name TGPAS. The cyclic olefin copolymer is a new series of amorphous thermoplastic engineering plastics with high transparency, moisture barrier properties, HDT ' Heat Deflection Temperature, and chemical resistance. C0C has optical properties comparable to PMMA (polymethyl methacrylate, acrylic resin) and has higher heat resistance than pc (polycarbonate). It also has better dimensional stability V than PMMA and PC. It has the advantages of improving water vapor tightness, increasing rigidity, heat resistance, easy to impart, etc. - pre-cutting performance. TOPAS (COC) 8007 grade materials are mainly used to process a variety of bottles for narcotics and pharmaceuticals. These bottles can withstand all sterilization methods commonly used by people to sterilize, such as steam sterilization, ethylene oxide disinfection, electronics and R-ray sterilization, etc., therefore, ring 4 94584 200950769 olefin copolymerization polymer (C0C) has a wide range of applications in the field of pharmaceutical packaging materials. Compared with glass and stainless steel materials, it does not contain Lewis acid such as alumina or iron oxide, thus ensuring the storage stability of sevoflurane. T0PAS is highly secure and the specifications have been certified by the US fda. NamSA tests TOPAS (COC) 8007 samples according to the US Pharmacopoeia. Under FDA C to steroid use conditions, TOPAS (COC) 8007 is fully compliant with FDA requirements. ExactTMP 1 astomers © manufactured by ExxonMob i 1 e is a copolymer of ethylene and olefin, which is a very rich product containing butene, hexene and octene copolymer. The following characteristics: outstanding low temperature and temperature impact resistance; low specific gravity; clean; outstanding heat sealing performance; excellent compatibility with various base polymers; excellent flexibility and puncture resistance; extremely high inorganic filling; Elongation and high elasticity; embrittlement and discoloration caused by radiation resistance. ExactTM Plastomers, model: 乂 乂 ( (^ 5061, is an ethylene and octene graft copolymer (ethylene alpha octene ❹ copolymers). Compliance with FDA regulations: 21 CFR 177. 1520 "Olefin polymer" (c) 3. 2c, It can be applied to raw materials and articles that come into contact with food. When the temperature reaches hot filling or higher than 150°F (less than 212°F), and in the 21CFR: 176. 170(c) Table 2, the olefin is used under the conditions of ΗC. The polymeric article can be in contact with all food types in Table 1 of CFR CFR 176. 170(c). In our examples, packaging made of TOPAS (COC) 8007 and ExactTMP 1 astomers (EXACT 5 0 61) was also selected. The container holds sevoflurane. In the packaging container, T0PAS ((3) 08007 is used as the main material constituent component, and EXACT 5061 is used as an auxiliary component, the purpose is to improve the performance of the container against the fall 5 94584 200950769. [Invention] The present invention relates to one type. The container material is produced by a ring-shaped cigarette core: the product comprises:::, a polymer, a container of the dimerization molecule and a graft of ethylene and octene. Space; and in the defined space The container sucks eight anesthetic heptafluoropyrans. The inner wall of the crucible is composed of the inner wall adjacent to the inner space of the ring, and the grafted copolymer of ethylene and octene is: 00 < The internal space is placed in a predetermined amount of heptafluoride. The container is defined as an opening = in fluid communication, and 5 ^ 'the opening is such that the inner space and the external environment are σ 5 pieces, and the gasket is in the cover of the olefin (HDPE) The inside of the cover has a gasket material of polyparaphenylene to contact the fluid in the container. The gasket has a foaming material. The i has a C, SI (PET) film or a polyethylene (PE) mouth. In the cover of the test PP~ sheet to seal the inner space defined by the container in the present invention, a predetermined amount of heptaphane is placed in the inner space of the present invention. - The general bottle type can also be used for seven. Fluorocarbon, the container can be a olefin copolymer:: its shape and capacity. It has been found that the compatibility and strength properties of a five-hearted and conjugated graft copolymer are prepared in a ring-shaped packaging container. , can 'have the desired vapor barrier properties, chemical film, fun and other packaging materials. Read general Molding processing method
採用以環_料料分子材料U 乙烯和辛烯的接枝 94584 200950769 共聚物製備的包裝容器來盛放七氟烷,具有所期望的蒸氣 阻隔性,而且不含有路易士酸,因此不存在使容器中盛放 的七氟烧降解的可能。 可用於本發明中之環狀烯烴共聚高分子的例子是美國A packaging container prepared by grafting a copolymer of molecular material U ethylene and octene, 94584 200950769, is used to hold sevoflurane, has desired vapor barrier properties, and does not contain Lewis acid, so there is no The possibility of degrading the heptafluorocarbon contained in the container. An example of a cyclic olefin copolymer polymer which can be used in the present invention is the United States.
Ticona公司所提供的Topas 8007(COC),8007代表的是一 種等級,本發明所屬技術領域中具有通常知識之人員可以 理解,在不脫離本發明申請專利範圍限定的範圍前提下, 可以採用其他等級的環狀烯烴共聚高分子。 ❹ 可用於本發明中之乙烯和辛婦的接枝共聚物是艾克森 美孚製造的 ExactTMPlastomers,型號:EXACT 5061,是乙 稀和辛烯的接枝共聚物(ethylene alpha octene copolymers) ° 七氟烧主要是用做吸入劑’因此溶液是相對可以揮發 的組分,若該溶液發生分解,其產生的分解產物如氫氟酸 等組成成分一旦吸入對人體有害,因此’在七氟烷的包裝 ❹中除了保證吸入劑七氟烷的高純度之外,更要保證七氟烷 溶液的穩定性。另外’本發明的七r氟烷純度高於99. 95wt%, 較佳者是純度尚於99. 98wt% ’上述的純度是在不含水的基 礎上計算出來的。 ... 本發明的優點是包裝於TOPAS(COC)和 ExactTMPlastomers(EXACT 5061)材質製作的容器中的七說 烷是穩定的,此溶液保存在該新型包裝中,在4〇°c高溫下 仍然穩定。 1 本發明穩定的七氟烷的水分在15〇ppm至1400ppm之 、^ 、 7 94584 200950769 · 間’且包裝或儲存在TOPAS(COC)8007和 ExaCtTMPlast〇mers(ExACT 5061)材質製成的容器内;在另 一個貫施例中,水分含量低於140ppm。上述的水分含量是 藉由Karl-Fischer方法檢測的。在該容器中常溫儲存6個 月或在40°C下,相對濕度20%下儲存6個月,七氟烷的純 度高於99. 95wt%,甚至達99. 98wt%。達到通常期望本發明 於包裝或碱存在 TOPAS(COC)8〇07 和 ExactTMPlast〇mers (EXACT 5061)材質製成的包裝容器内的七氪烷不降解。 ❹ 下述實施例僅用於說明的目的’而不用於限制本發明 的範圍〇 , 【實施方式】 實施例 實施例1 本實施例介紹的是含水量在150ppm至1400ppm之間的 七氟烷保存在 TOPAS(COC)8007 及 ExactTMPlastomers ◎ (EXACT 5061)材質製成的容器内的穩定性。在20Ό8年1月 開始的一項試驗中,藉由Karl-Fischer方法檢測七銳燒含 水量為165ppm。將一份七氟烷樣本放置在一個先前已在 l〇5°C溫度下乾燥過2小時的TOPAS(COC)8007和 , , · .The Topas 8007 (COC), 8007 provided by Ticona Corporation represents a level, and those having ordinary knowledge in the art to which the present invention pertains can understand that other levels can be employed without departing from the scope defined by the scope of the present invention. A cyclic olefin copolymer polymer.接枝 The graft copolymer of ethylene and sage which can be used in the present invention is ExactTM Plastomers manufactured by ExxonMobil, model: EXACT 5061, which is an ethylene alpha octene copolymers ° heptafluorocarbon Burning is mainly used as an inhalant'. Therefore, the solution is a relatively volatile component. If the solution is decomposed, the decomposition products produced by it, such as hydrofluoric acid, are harmful to the human body once inhaled, so 'packaging in sevoflurane In addition to ensuring the high purity of the inhalant sevoflurane, it is necessary to ensure the stability of the sevoflurane solution. Further, the purity of the heptafluoroalkane of the present invention is higher than 99.95 wt%, preferably the purity is still 99.98 wt%. The above purity is calculated on the basis of no water. The advantage of the present invention is that the seven alkane encapsulated in a container made of TOPAS (COC) and ExactTM Plastomers (EXACT 5061) is stable, and the solution is stored in the new package at a high temperature of 4 ° C. stable. 1 The stable sevoflurane of the present invention has a moisture content of 15 〇 ppm to 1400 ppm, and 7 94584 200950769 · and is packaged or stored in a container made of TOPAS (COC) 8007 and ExaCtTM Plast 〇mers (ExACT 5061). In another embodiment, the moisture content is less than 140 ppm. The above moisture content is detected by the Karl-Fischer method. The sevoflurane has a purity of more than 99.95 wt%, even up to 99. 98 wt%, in the container at room temperature for 6 months or at 40 ° C, at a relative humidity of 20% for 6 months. It is generally desired that the present invention is not degraded in heptanethane in a packaging container made of a material such as TOPAS (COC) 8〇07 and ExactTM Plast〇mers (EXACT 5061) in the presence of a package or a base. The following examples are for illustrative purposes only and are not intended to limit the scope of the invention. [Embodiment] EXAMPLES Example 1 This example describes the preservation of sevoflurane having a water content between 150 ppm and 1400 ppm. Stability in containers made of TOPAS (COC) 8007 and ExactTM Plastomers ◎ (EXACT 5061). In a test that began in January 2000, the water content of Qirui was 165 ppm by the Karl-Fischer method. A sample of sevoflurane was placed in a TOPAS (COC) 8007 and , which had been previously dried at l〇5 °C for 2 hours.
ExactTMPlastomers(EXACT 5061)材質製成的容器内,封 口,然後將樣本置於40°C下,相對濕度75%下,保持周圍 相對濕度。在6個月’運用氣相層析法對七氟烷的純度進 行分析,結果為99. 959wt%,未發生分解作用。 實施例2 94584 200950769 本實施例介紹的是含水量在150ppm至1400ppm之間的 七氟烧保存在 TOPAS(COC)6013 和 ExactTMPlastomers (EXACT 5061)材質製成的容器内的穩定性。在2008年1月 « 開始的一項試驗中,藉由Karl-Fischer方法檢測七氟烧含 水量為1300ppm。將一份七氟烷樣本放置在一個先前已在 105°C溫度下乾燥過2小時的TOPAS(COC)8007和 ExactTMPlastomers(EXACT 5061)材質製成的容器内,封 口,然後將樣本置於40°C下,相對濕度75%。在6個月後, 〇運用氣相層析法對七氟烷的純度進行分析,結果為 99. 964wt%,未發生分解作用。 實施例3 本實施例介紹的是含水量在140ppm以下的七氟烧保 存在 TOPAS(COC)8007 和 ExactTMPlastomers(EXACT 5061) 材質製成的容器内的穩定性。在2008年01月開始的一項 試驗中,藉由Karl-Fischer方法檢測七氟烷含水量為 ❹80ppm。將一份七氟烷樣本放置在一個先前已在i〇5°c溫度 下乾燥過 2:小時的 TOPAS(COC)8007 和 Exac.tTMPlastomers.. (EXACT 5061)材質製成的容器内,封口並用熱塑膜包裝, 然後將樣本置於40°C下’相對濕度75%下,保持周圍相對 濕度。在6個月後,運用氣相層析法對七氟烷的純度進行 分析,結果為99. 959wt%,未發生分解作用。 實施例4 .下表中的其他資料也證實了七氟烷長期保存在 TOPAS(COC)8007 及 ExactTMPlas"tomers(EXACT 5061 )材質製 94584 200950769 成的容器内的穩定性。七氟烷的含水量是經Karl Fischer 法測定的’將七氟烧放置在250ml的t〇PAS(COC)8007及Inside the container made of ExactTM Plastomers (EXACT 5061), seal and then place the sample at 40 ° C and maintain relative humidity at 75% relative humidity. The purity of sevoflurane was analyzed by gas chromatography at 6 months. The result was 99.959 wt%, and no decomposition occurred. Example 2 94584 200950769 This example describes the stability of heptafluoropyrene stored in a container made of TOPAS (COC) 6013 and ExactTM Plastomers (EXACT 5061) having a water content of between 150 ppm and 1400 ppm. In January 2008, the initial test was conducted to determine the water content of sevoflurane by the Karl-Fischer method to be 1300 ppm. Place a sample of sevoflurane in a container made of TOPAS (COC) 8007 and ExactTM Plastomers (EXACT 5061) that had been previously dried at 105 ° C for 2 hours, seal, and then place the sample at 40 ° Under C, the relative humidity is 75%. After 6 months, the purity of sevoflurane was analyzed by gas chromatography, and the result was 99.964 wt%, and no decomposition occurred. EXAMPLE 3 This example describes the stability of a heptafluorocarbonate having a water content of less than 140 ppm in a container made of TOPAS (COC) 8007 and ExactTM Plastomers (EXACT 5061). In a test started in January 2008, the water content of sevoflurane was measured by the Karl-Fischer method to be ❹80 ppm. A sample of sevoflurane was placed in a container made of TOPAS (COC) 8007 and Exac.tTM Plastomers.. (EXACT 5061) which had been previously dried at i〇5 °C for 2: hour, sealed and used. The thermoplastic film was packaged, and then the sample was placed at 40 ° C 'relative humidity 75%, maintaining the relative humidity around. After 6 months, the purity of sevoflurane was analyzed by gas chromatography, and the result was 99.959 wt%, and no decomposition occurred. Example 4. Additional information in the table below confirms the long-term stability of sevoflurane in containers made of TOPAS (COC) 8007 and ExactTM Plas "tomers (EXACT 5061) material 94584 200950769. The water content of sevoflurane is determined by the Karl Fischer method. The heptafluorocarbon is placed in 250 ml of t〇PAS (COC) 8007 and
VV
ExactTMPlastomers(EXACT 5061)材質製成的容器内,然後 在一定條件下或室溫條件下將部分七氟烷進行穩定性試 驗。所有試驗中,七氟烷的純度(藉由氣相層析法測定)都 說明了未發生分解作用。 容器 類型 生產曰期 最初的 水分 持續 時間 條件 最終產物 結果 2008.01 90 ppm 180天 25〇c/60% 濕度 99. 971% 不分解 250ml 2008.01 170 ppm 180天 25〇C/60% 濕度 99. 964% 不分解 2008. 01 1100 ppm 180天 25〇C/60% 99. 977% 不分解 〇 〇 雖然該發明對實施例已經作了詳 w 做的目的只是為了舉例說明,而不茲的描述柳^ 何限制。本㈣所屬技術領域中對本發明進行1 理解,在本發縣礎上對本發明^知識之人員應, 在本發明的保護範圍内。 仃的任何變化、改變; 【圖式簡旱-明】 無 7»*> 【主要元件符號說明】 無 94584Partial sevoflurane was tested for stability in a container made of ExactTM Plastomers (EXACT 5061) and then under certain conditions or at room temperature. The purity of sevoflurane (determined by gas chromatography) in all experiments indicated that no decomposition occurred. Container Type Production Prime Water Moisture Duration Conditions Final Product Results 2008.01 90 ppm 180 Days 25〇c/60% Humidity 99. 971% Does not decompose 250ml 2008.01 170 ppm 180 days 25〇C/60% Humidity 99. 964% No Decomposition 2008. 01 1100 ppm 180 days 25〇C/60% 99. 977% Not decomposed 〇〇 Although the invention has been described in detail for the purpose of illustration only, not a description . In the technical field of the present invention, the present invention is understood to be within the scope of protection of the present invention. Any change or change of 仃; [Graphic Drought-Ming] No 7»*> [Main component symbol description] None 94584
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW97149631A TW200950769A (en) | 2008-06-06 | 2008-12-19 | New material used for package for sevoflurane |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW97121058 | 2008-06-06 | ||
TW97149631A TW200950769A (en) | 2008-06-06 | 2008-12-19 | New material used for package for sevoflurane |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200950769A true TW200950769A (en) | 2009-12-16 |
Family
ID=44871485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW97149631A TW200950769A (en) | 2008-06-06 | 2008-12-19 | New material used for package for sevoflurane |
Country Status (1)
Country | Link |
---|---|
TW (1) | TW200950769A (en) |
-
2008
- 2008-12-19 TW TW97149631A patent/TW200950769A/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2020114437A (en) | Prefilled container systems | |
JP5022368B2 (en) | Method for sterilizing elastomeric sealing articles | |
AU2001245850B2 (en) | Containers and peelable seal containers of new non-pvc material | |
CN1970288B (en) | Seven-layer coextrusion membrane for transfusion and its production method | |
NO318852B1 (en) | Containers for parenteral fluids | |
ATE543875T1 (en) | POLYAMIDE BLEND COMPOSITION WITH EXCELLENT GAS BARRIER PERFORMANCE | |
JP2009209342A (en) | Propylene resin composition and its molded article | |
CN108883232A (en) | For the syringe body of pre-encapsulated injector, injection device and pre-encapsulated injector | |
BR112012011925B1 (en) | POLYMERIC COMPOUND FOR SEALS IN USE WITH GREASY FILLING MATERIALS AND PVC-FREE CLOSING OR COVER | |
JP4705703B2 (en) | Polypropylene medical blow container | |
JP2010248425A (en) | Molding for medical use | |
US20140166527A1 (en) | Inhalation Anesthetic Product | |
TW200950769A (en) | New material used for package for sevoflurane | |
WO2009052739A1 (en) | Method for storing the inhalation anesthesia and container thereof | |
CN107835840B (en) | Polypropylene resin composition and medical molded body obtained using same | |
JP6565435B2 (en) | Propylene resin composition for medical kit preparation for radiation sterilization and medical kit preparation thereof | |
JP2012152933A (en) | Propylene-based resin injection-molded product | |
WO2015033876A1 (en) | Method for producing sterilized medical molded body | |
JP2009082698A (en) | Member for dialysis | |
JP2017055723A (en) | Packaging bag for cell culture vessel | |
JP2010167635A (en) | Hygroscopic laminate and sealing plug using the same | |
JP2021075690A (en) | Thermoplastic resin composition, molding and laminate | |
JP6819230B2 (en) | Packaging bag for cell culture container | |
JP2005314490A (en) | Polypropylene resin composition and medical equipment therefrom, prefilled syringe | |
ES2693336T3 (en) | Medical container |