Claims (1)
200914063 13.包覆在奈米乳液中多紛類之漠度（mM) 奈米乳液粒徑（nm) 15.體積分率（％) 16·穿透皮膚的累積量，平方公分(η〆— Π.穿透皮膚的累積時間（小時） 十、申請專利範圍 1.本發明之特點為：⑴該組成的界面活性劑皆為生 醫相容性材料，因不需加入醇類的輔助界面活性 劑，因此可以經皮、口服及注射等途徑進入人體； (2 )界面活性層保護以增進多酚類衍生物穩定 性，油相則可增進多酚類衍生物溶解度；（3)奈 米乳液增進藥物的溶解度，可攜帶傳輸藥物容量 比傳統的乳液或乳霜多；（4)以適當？11為74的 磷酸鹽緩衝生理食鹽水溶液稀釋之後，可穩定2 天以上，使之更有機會被生理吸收利用；（5 )奈 米乳液的粒徑範圍在為5〜100奈米（nm)，其易= 穿透皮膚’進入皮下組織之微血管中，可以提升 生體使用率；（6)製備方法簡單，以頻率 2kHz〜50MHz超音波震盈適當時間。此奈米乳液 製備方法包括： 一種多紛類 一種可食用的油脂類 200914063 一種具有HLB大於1之界面活性劑 一種脂質及超音波 2.如申請專利範圍第一項所述利用多酚類衍生物包 括薑黃素（Curcumin)、蝦青素（Astaxanthin)、紅色 素（Lycopene)、葉黃素（Lutein)、玉米黃素 (Zeaxanthin)、葛根（Radix Puerariae)、白蘇蘆醇 (Resveratrol)、原花青素（Proanthocyanidins)、類 黃酮（Bioflavonoids )、木紛素（Lignans)、黃酮類 (Flavoniods)、單寧（Tannin)、芹菜素（Apigenin)、 木犀草素（Luteolin)、芸香素（Rutin)、柑橘多酚 (Hesperidin)、橄欖多盼（Oleuropein)、酷·醇 (tyrosol)、可可多盼（Cacao Polyphenol)、辣椒素 (Capsaicin)、葉綠素（Chlorophyl)、麻黄素 (Ephedrin)、蒜素（Allicin)、毛地黄黄酮（Luteolin)、 葛根異黃酮（PuerariaPE)、大豆甘元（Daidzein)、大豆 甘（Daidzin )、仙鹤草酚（Agrimophol)、山姜素 (Alpinetin)、花色素（Anthocyanosides)、芹菜武 (Apiin)、蒼術酮（Atractylon)、補骨脂紛 (Bakuchiol)、佛手酚（Bergaptol)、白果素7-去甲基 200914063 銀杏雙黃酮（Bilobetin)、二去甲氧基姜黃素 (Bisdemethoxycurcumin)、辣椒黃素（Capsanthin)、 辣椒萃取物（Capsicum Extract)、辣椒紅素 (Capsorubin)、紅花素（Carthamidin)、大黃紛 (Chrysophanol)、莪術醇（Curcumol)、莪二酮 (Curdione)、去曱氧基姜黃素（Demethoxy-curcumin)、丁香紛（Eugenol)、蒲公英黃 _ (Flavonoids)、銀杏黃酮（Ginkgo Biloba Extract)、 棉紛（Gossypol)、和濃朴酴（Honokiol)、律草酮 (Humulone)、異補骨脂黃酮（Isobavachin)、大豆異 黃酮（Isoflavones)、葛根提取物（KudzuP.E)、濃朴 紛（Magnolol)、曱基麥冬二氫高異黃酮A， B( Methylophiopogonanone A, B)、麥冬二氫高異 黃酮 A，B (Ophiopogonanone A, B)、麥冬高異黃 酮 A，B (Ophiopogonone A, B)、丹皮驗（Paeonol)、 紫錐菊多盼（Phenolic Compounds)、廣藿香酮 (Pogostone)、1 石權杆多紛（Polypheno)、葛根總 黃酮（Pueraria Flavonid)、葛根提取（Pueraria Root P.E)、葛根素物（Puerarin)、青黛酮（Qingdainone)、 白藜蘆醇（Resveratrol)、 漏蘆甾酮 10 200914063 (Rhapontisterone)、大黃酸（Rhein)、大豆提取物 (Soy bean P.E)、丹參酮 IIA(Tanshinone IIA)、丹參 酮 I (Tanshinone I)、丹參酮 IIB(Tanshinone IIB)、 茶多酚（Tea Polyphenol)、銀杏總黃酮（Total Ginkgo Flavone-Glycoides)、薑黃提取物（Turmeric P.E)、 薑黃素（Turmerone)、芳薑黃酮（arturmerone)。 3.如申請專利範圍第一項所述利用奈米乳液來包覆 多酚類衍生物的方法，其中一種可食用的油脂類 為不飽和脂肪酸（C22碳鏈中至少含有一個（含） 以上雙鍵或參鍵）及碳鏈少於C14的油脂類包括 可作為，包括：芝麻油（Seamy Seed oil)、甜杏仁 油（Almond Sweet oil)、酪梨油（Avocado Oil)、琉 璃苣油（Borage Oil)、月見草油（Evening primrose Oil)、榛果油（Hazelnut Oil)、荷荷芭油（J〇j〇ba Oil)、橄欖油（Olive Oil)、玫魂果實油（R0se Hip Seed Oil)、向曰葵油（Sunflower Oil)、紅花杆油 (Safflower Oil)、英國胡桃油（Walnut Oil)、杏桃核 仁油（Apricot Kernel Oil)、油菜籽油（Canola Oil， Rapeseed Oil)、蓖麻油（Castor Oil)、亞麻薺油 (Camelina Oil)、葡萄籽油（Apeseed Oil)、小麥胚 芽油（Wheatgerm Oil)、昆士蘭堅果油（澳洲堅果油） 200914063 (Macadamia Oil)、花生油（Peanut Oil)、椰子油 (Coconut Oil)、可可脂（Cocoa Butter)、乳油木果 脂（Shea Butter)、紅標櫚油（Carotino Premium Oil)、油酸乙脂（Ethyl Oleate)、米胚芽油（Germ Oil)、棕櫚油（Palm Oil)、玉米油（Corn Oil)、大麻 軒油（Hemp Oil)、覆盆子奸油（Raspberry Seed Oil)、小紅莓籽油（Cranberry Seed Oil)、南瓜籽油 (Pumpkin Seed Oil)、開心果油（Pistachio Nut Oil )、茶花油（Camellia Oil)、茶籽油（Camellia Seed Oil)、大豆油（Soybean Oil)、芬花油（Canola Oil)、 氫化蓖麻油（Castor Oil, Hydrogenated)、羊毛脂 (Lanolin)油酸（Oleic Acid)、硬脂酸聚氧乙烯酯 (Polyoxyethylene Stearates)、聚醋酸乙烯酞酸酯 (Polyvinyl Acetate Phthalate)、沒食子酸丙醋 (Propyl Gallate)、二氧化硅二曱硅油 (Simethicone)、氫化植物油（Vegetable Oil, Hydrogenated)、氩化植物油（硬脂）栓劑基質 (Suppository Bases, HardFat)、薄荷油（Peppermint Oil)、十四酸異丙醋（Isopropyl Myristate, IPM)等 其中之一， 4·如申請專利範圍第一項所述利用奈米乳液來包覆 多酚類衍生物的方法，其中該大於HLB值1的界面 12 200914063 活性劑成分包括：環氧乙烷•環氧丙烷-環氧乙烷 (PEO-PPO-PEO)共聚物聚醚系列（-(PPO)a (PEO)b (PPO)a- ) ' PEG-8 單硬脂酸酯（PEG-8 Monostearate)、PEG-8 月桂醚（PEG-8 Laurylether)、 油酸（Oteic Acid)、失水山梨醇三油酸酯（Sorbitan Tribleate，Span 85 )、失水山梨醇三油酸醋（Sorbitan Trioleate, Arlacel 85)、聚氧乙稀山梨醇蜂堪衍生物 (Polyoxyethylene Sorbitol Beeswax Derivative, Atlas G-1706)、失水山梨醇三硬脂酸S旨（Soibitan Tristearate，Span 65)、失水山梨醇三硬脂酸醋 (Sorbitan Tristearate，Arlacel 65)、聚氧乙烯山梨醇 六硬脂酸 S旨（Polyoxyethylene Sorbitol Hexastearate， Atlas G-1050)、乙二醇脂肪酸醋（Ethyleneglycol Fatty Acid Ester，Emcol EO-50)、乙二醇脂肪酸醋 (Ethyleneglycol Fatty Acid Ester, Emcol ES-50)、聚 氧乙浠山梨醇蜂躐衍生物（Polyoxyethylene Sorbitol Beeswax Derivative, Atlas G-1704)、丙二醇脂肪酸 酉旨（Propylene Glycol Fatty Acid Ester, Emcol PO-50)、丙二醇單硬脂酸酉旨（Propylene Glycol Fatty Acid Ester，Atlas G-922)、丙二醇單硬脂酸酷（Pure Propylene Glycol Fatty Acid Ester)、丙二醇單硬脂 酸醋（Propylene Glycol Fatty Acid Ester, Atlas G-2158)、丙二醇脂肪酸酯（Ethylene Glycol Fatty 13 200914063 Acid Ester, Emcol PS-50)、乙二醇脂肪酸酯 (Ethyleneglycol Fatty Acid Ester, Emcol EL-50)、丙 二醇脂肪酸酯（Propylene Glycol Fatty Acid Ester， Emcol PP-50)、失水山梨醇倍半油酸酯（Sorbitan Sesquioleate，Arlacel C)、失水山梨醇倍半油酸酯 (Sorbitan Sesquiolate, Arlacel 83)、聚氧乙烯山梨醇 (Polyoxyethyle Esorbitol 4,5 Oleate, Atlas G-2859)、單硬脂酸甘油（Glycerol Monostearate， Atmul 67)、二硬脂酸甘油醋（Glycol Distearate)、失 水山梨醇三油酸醋（Sorbitan Trioleate)、硬脂酸丙二 醇酯（Glycol Stearate)、失水山梨醇三硬脂酸酯 (Sorbitan Tristearate)、油酸甘油醋（Glyceryl Oleate)、二硬脂酸蔗糖酯（Sucrose Distearate)、聚 氧乙稀山梨醇六硬脂酸酯（Polyoxyethylene Sorbitol Hexastearate)、失水山梨醇倍半油酸酯（Sortitan Sesquioleate)、聚氧乙烯山梨醇4.5油酸酯 (Polyoxyethyle Esorbitol 4.5 Oleate)、單硬脂酸甘油 酯（Glycerol Monostearate)、PEG-5 蓖麻油（PEG-5 Castor Oil)、羊毛脂（Lanolin)、羊毛醇（Lanolin Alcohol)、膽固醇（Cholesterol)、經基化羊毛脂 (Polyoxyethylene Sorbitol Beeswax)、失水山梨醇單 油酸醋（Sorbitan Monooleate)、失水山梨醇油酸酉旨 (Sorbitan Oleate)、PEG-2 硬月旨酸醋（PEG-2 14 200914063 Stearate)、失水山梨醇硬脂酸醋（Sorbitan Stearate)、失水山梨醇異硬脂酸酯（Sorbitan Isostearate)、硬脂醇趟-2(Steareth-2)、PEG-7 氫化 蓖麻油（PEG-7 Hydrogenated Castor Oil)、油醇謎 -2(01eth-2)、PEG-4二油酸酯（PEG-4 Dioleate)、失 水山梨醇棕櫚酸酯（Sorbitan Palmitate)、油醇趟 -3(01eth-3)、羊毛醇謎-(n)(Laneth-(n))、單硬脂酸 甘油醋（Glycerol Monostearate, Atmul 84)、單硬脂 酸甘油醋(Glycerolmonostee (Rateglycerol Monostearate), Tegin 515)、單硬脂酸甘油醋 (Glycerol Monostearate，Aldo 33)、單硬脂酸甘油酉旨 (Pure Hydroxylatedlanolin)、經基化羊毛脂 (Ohlan Polyoxyethylene Sorbitol Beeswax)、聚氧乙 烯山梨醇蜂躐衍生物（AriasG-1727 Derivative)、丙 二醇脂肪酸醋（Propylene Glycol Fatty Acid Ester, Emcol PM-50)、失水山梨醇單油酸醋（Sorbitan Monooleate, Span 80)、失水山梨醇單油酸酉旨 (Sorbiatan Monooleate, Arlacel 80)、丙二醇單月桂 酸醋（Propylene Glycol Monolaurate，Atlas G-917)、 丙二醇單月桂酸醋（Propylene Glycol Monolaurate， AtlasG-3851)、丙二醇脂肪酸醋（Propylene Glycol Fatty Acid Ester，EmcolPL-50)、失水山梨醇單硬脂 酸醋（Sorbitan Monostearate，Span 60)、失水山梨醇 15 200914063 單硬脂酸 S旨（Sorbitan Monostearate，Arlacel 60)、二 乙二醇單油酸酯（Diethylene Glycol Monooleat, AtlasG-2139)、二乙二醇脂肪酸 S旨（Diethyleneglycol Fatty Acid Ester, Emcol DO-50)、二乙二醇單硬脂酸 醋（Diethylene Glycol Monostearate，Atlas G-2146)、 二乙二醇脂肪酸酉旨（Diethylene Glycol Fatty Acid Ester, Emcol DS-50)、聚氧乙烯（2EO)油醇醚 (P.O.E.(2) Oleylalcohol，Ameroxol OE-2)、聚氧乙烯 山梨醇蜂堪衍生物（Polyoxyethylene Sorbitol Beeswax Derivative，Atlas G-1702)、二乙二醇脂肪 酸醋（Diethylene Glycol Fatty Acid Ester，Emcol DP，50)、單硬脂酸甘油醋（Glycerol Monostearate， Aldo 28)、單硬脂酸甘油酯（Tegin Glycerol Monostearate)、二乙二醇脂肪酸酉旨（Diethylene Glycol Fatty Acid Ester, Emcol DM-50)、曱基葡萄 糖普倍半硬脂酸赂（Methyl Glucoside Seequisterate，Glucate-SS)、聚氧乙烯山梨醇蜂躐 衍生物（Polyoxyethylene Sorbitol Beeswax Derivative，Atlas G-l725)、二乙二醇單月桂酸醋 (Diethylene Glycol Monolaurate，Atlas G-2124)、二 乙二醇脂肪酸醋（Diethylene Glycol Fatty Acid Ester, Emcol DL_50)、 二乙二醇單月桂酸酯 (Glaurin Diethylene Glycol Monolaurate)、失水山 16 200914063 梨醇單棕櫚酸 S旨（Sorbitan Monopalmitate，Span 40)、失水山梨醇單棕櫚酸酯（Sorbitan Monopalmitate，Arlacel 40)、聚氧乙烯二油酸醋 (Polyoxyethylene dioleate，Atlas G-2242)、四乙二醇 單硬脂酸醋（Tetraethylene Glycol Monostearate, Atlas G-2147)、四乙二醇單油酸醋（Tetraethylene Glycol Mbnooleat，Atlas G-2140)、聚氧丙稀甘露醇 二油酸醋（Volvoxvlropylene Mannitoldioleate, Atlas G-2800)、聚氧乙烯山梨醇羊毛脂衍生物 (Polyoxyethylene Sorbitol Lanolin Derivative, Atlas G-1425)、聚氧丙烯（5PO)羊毛醇醚（Splulan PB-5 P.0.P(5) Laolin Alcohol)、失水山梨醇單月桂酸酯 (Sorbitan Monolaurate，Span 20)、聚氧化乙烯山梨 聚醣三油酸醋（Polyoxyethylene Sorbitan Trioleate， Tween 85)、聚乙二醇（400)單硬脂酸醋（Polyethylene Glycol 400 Monostearate)、聚氧乙浠（20)失水山梨 醇單硬脂酸S旨（Polysorbate 60，Tween 60)、聚氧乙 晞單硬脂酸醋（Polyoxyethylene Monostearate，Myrj 49)、聚山梨醇針脂肪酸醋二十（Polysorbate 20, Tween 20)、純月桂基硫酸鈉（Pure Sodium Lauryl Sulfate)、N-十六烧基乙基嗎琳基乙基硫酸納 (N-cetyl N-ethyl Morpholinium Ethosulfate)、油酸 奸（Potassium Oleate)、油酸納（Sodium Oleate)、 17 200914063 PEG-90 杏仁甘油酉旨（peg-90 Apricot Kernel Glycerides)、PEG-40硬脂酸酯（PEG-40 Stearate)、 (：12-13棕櫚油醚-23((：12-13?&加11-23)、？£〇-100硬 脂酸酯（PEG-100 Stearate)、烷基芳基磺酸鹽（Alkyl Aryl Sulfonate)、脂酸蔗糖酯（和）二硬脂酸蔗糖 酯（Sucrose Stearate (and) Sucrose Distearate)、三乙 醇胺油酸醋（Triethanolamine Oleate)、油醇醚 -lO(Oleth-lO)、PEG-35 蓖麻油（PEG-35 Castor Oil)、 PEG-40 氫化萬麻油（PEG-40 Hydrogenated Castor Oil)、PEG-40 蓖麻油（PEG-40 Castor Oil)、PEG-8 月 桂酸醋（PEG-8 Laurate)、月桂酸肌氨酸（Lauroyl Sarcosine)、PEG-6 GTCC甘油 g旨（PEG-6 Capprylic, Capric Glycerides)、 錄躐硬脂醇醚 -12(Ceteareth-12)、PEG-15 月桂甘油酯（PEG-15 Gluceryl Laurate)、PEG-12 硬脂酸醋（PEG-12 Stearate)、PEG-24膽鐵醇醚（PEG-24 Cholesterol)、 PPG-20 羊毛醇醚（PPG-20 Lanolin Alcohol)、 PEG.40/45 氫化蓖麻油（PEG-40/45 Hydrogenated Castor Oil)、PEG-60杏仁油甘油醋（和） PEG-60(Almond Glycerides (and) PEG-6GTCC) ' 甘油酯（Caprylic/Capric Glycerides)、硬脂酸蔗糖酯 (Sucrose Stearate)、PEG-60 氫化蓖麻油（PEG-60 Hydrogenated Castor Oil)、PEG-20 失水山梨醇硬脂 18 200914063 酸醋（Polysorbate 60)、PEG-20失水山梨醇油酸醋 (Polysorbate 80)、PEG-60 甜杏仁甘油醋（PEG-60 Almond Glycerides)、PEG-42 Babassu 甘油醋 (PEG-42 Babassu Glycerides)、PEG-60月見草甘油 酉旨（PEG-60 Evening Primrose Glycerides)、PEG-45 玉米油甘油酯（PEG-45 Corn Glycerides)、PEG-45 棕櫚仁油甘油醋（PEG-45 Palm Kernel Glycerides)、 PEG-60 Maracuja 甘油醋（PEG-60 Maracuja Glycerides)、PEG-20甲基葡萄糖苷倍半油酸酯 (PEG-20 Glucamate SS)、石更脂醇醚-20(Steareth-20)、 油醇醚-20(01eth-20)、硬脂醇醚-21(Steareth-21)、 PEG-20失水山梨醇棕櫚酸醋（Polysorbate 40)、鯨堪 硬脂醇醚-20(Ceteareth-20)、PEG-20硬脂酸酯 (PEG-20 Stearate) 、PEG-75 羊毛脂（PEG-75 Lanolin)、錄蠘硬脂醇 -25(Ceteareth-25)、PEG-20 失水山梨醇月桂酸酯（Polysorbate 20)、聚氧丙烯硬 脂酸醋（Polyoxypropylene Stearate)、PEG-5羊毛醇 醚（PEG-5 Lanolin Alcohol)、PEG-15蓖麻油（PEG-15 Castor Oil)、PEG-8 二油酸醋（PEG-8 Dioleate)、失 水山梨醇月桂酸醋（Sorbitan Laurate)、油醇醚 -5(01eth-5)、聚甘油-3 聚蓖麻油酸酯（Polyglyceryl-3 Polyricinoleate)、聚氧乙烯氧丙晞油酸酉旨 (Polyoxyethylene Oxypropylene Oleate)、四乙二醇 19 200914063 單月桂酸醋（Tetraethylene Glycol Monolaurate)、 C12-13棕櫚油醚-4(C12-13 Pareth-4)、聚氧乙烯月 桂醚（Polyoxyethylene Lauryl Ether)、六乙二醇單硬 脂酸醋（Hoxaethylene Glycol Monostearate)、椰油酰 肌氨酸（Cocoyl Sarcosine)、餘蠛硬脂醇醚 -6(Ceteareth-6)、PPG-5 羊毛醇醚（PPG-5 Laolin Alcohol)、錄堪醇醚-5(和）錄蠛硬脂醇醚-7(Ceteth-5 (and) Ceteareth-7)、聚氧乙烯十六烧基謎 (Polyoxyethylene Cetyl Ether)、PEG-20失水山梨醇 三硬脂酸醋（PEG-20 Sorbitan Tristearate)、PEG-7 椰油酸甘油醋（PEG-7 Glyceryl Cocoate)、自乳化硬 脂酸單甘酯（Glyceryl Stearate(S/E))、PEG-8硬脂酸 酉旨（PEG-8 Stearate)、硬脂酸甘油S旨（和）PEG 100 硬脂酸 S旨（Glyceryl Stearate (and) PEG 100 Stearate)、PEG-20失水山梨醇三油酸醋（Polysorbate 85)、聚氧乙稀氧丙烯油酸S旨（Polyoxyethylene Oxypropylene Oleate)、PEG-8 月桂甘油醋（PEG-8 Glyceryl Laurate)、PEG-8 硬脂酸醋（PEG-8 Stearate)、PEG-29蓖麻油（PEG-29 Castor Oil)、聚 氧乙浠月桂醚（Polyoxyethylene Lauryl Rther，Brij 35)、聚氧乙稀單硬脂酸醋（Polyoxyethylene monolaurate，Myrj 52)、聚氧乙浠單硬脂酸醋 (Polyoxyethylene Monolaurate，Myrj 53)、聚氧乙稀 20 200914063 單硬脂酸醋（Polyoxyethylene Monolaurate，Atlas G-2159)、聚氧乙烯山梨醇羊毛脂油酸衍生物 (Polyoxyet Hylene Sorbitol Lanolin Oleate Derivative，Atlas G-1493)、聚氧乙稀山梨醇羊毛脂 衍生物（Polyoxyethylene Sorbitol Lanolin, Atlas G-1425 derivative)、聚氧丙烯硬脂酸醋 (Polyoxypropylene Stearate，Atlas G-3608)、聚氧乙 烯（5EO)羊毛醇醚（P.O.E(5) Lanolin Alcohol, Solulan 5)、失水山梨醇月桂酸醋（Sorbitan Monolaurate, Arlacel 20)、聚氧乙烯脂肪酸 (Polyoxyethylene Fatty Acid, Emulphor VN-430)、聚 氧乙浠氧丙烯油酸醋（Polyoxyethylene Oxypropylene Oleate，Atbs G-2111)、聚氧乙稀山梨 醇蜂躐衍生物（Polyoxythylene Sorbitol Beeswax Derivative, Atlas G-l734)、四乙二醇單月桂酸酉旨 (Tetraethylene Glycol Monolaurate, Atlas G-2125) ' 聚氧乙烯月桂 ϋ (Polyoxyethylene Lauryl Ether, Brij 30)、氧乙烯（4EO)失水山梨醇單硬脂酸酯 (Polyoxethylene Sorbitan Monostearate, Tween 61) ' 六乙二醇單硬脂酸醋（Hoxaethylene Glycol Monostearate，Atlas G-2154)、聚氧丙浠（5PO)羊毛 醇醚（P.0.P(5) Laolin Alcohol, Splulan PB-5)、聚氧 乙稀（5EO)失水山梨醇單油酸醋（Polyoxyethylene 21 200914063 Sorbitan Monooleate，Tween 81)、混合脂肪酸和樹 脂酸的聚氧乙烯酯類（Polyoxyethylene Esters of Mixed Fatty and Resin Acids，Atlas G-1218)、聚氧 乙稀十六烧基醚（Polyoxyethylene Cetyl Ether, AtlasG-3806)、聚氧乙烯（20EO)失水山梨醇三硬脂 酸醋（Polyoxyethylene Sorbitan Tristearate, Tween 65)、聚氧乙浠月桂醚（Polyoxyethylene Lauryl Ether， Atlas G-3705)、聚氧乙烯（20EO)失水山梨醇三油酸 酉旨（Polyoxyethylene Sorbitan Trioleate, Tween 85)、 聚氧乙浠氧丙浠油酸酯（Polyoxyethylene Oxypropylene Oleate，Atlas G-2116)、聚氧乙浠羊毛 月旨衍生物（Polyoxyethylene Lanolin Derivative, Atlas G-1790)、聚氧乙烯單油酸醋（Polyoxyethylene Monooleate，Atlas G-2142)、聚氧乙烯單硬脂酸醋 (Polyoxyethylene Monostearate, Myrj 45)、聚氧乙浠 單油酸醋（Polyoxyethylene Enemonooleate，Atlas G-2141)、聚氧乙烯單油酸醋（Polyoxyethylene Monooleate，P.E.G.400 Monooleate)、聚氧乙稀單棕 搁酸醋（Polyoxyethylene Monopalmitate, Atlas G-2076)、聚氧乙烯單硬脂酸醋（Polyoxyethylene Monostearate, S-541)、聚氧乙稀單硬脂酸酯 (Polyoxyethylene Monostearate, P.E.G.400 Monostearate)、烧基芳基續酸鹽（Alkyl Aryl 22 200914063 Sulfonate，Atlas G-3300)、三乙醇胺油酸酯 (Triethanolamine Oleate)、聚氧乙烯（10EO)油醇醚 (Ρ.Ο.Ε·(10) Oleyl Alcohol，Ameroxl OE-10)、聚氧乙 烯單月桂酸醋（Polyoxyethylene Monolaurate, Atlas G-2127)、聚氧乙稀烧基盼（Polyoxyethylene Alkyl Phonol, Igepal CA-630)、聚氧乙稀（10EO)乙酰化羊 毛脂衍生物（Acetylated P.O.E.(IO) Landin Derivative, Solulan 98)、聚氧乙烯山梨醇羊毛脂衍 生物（Polyoxyethylene Sorbitol Landing Derivative, Atlas G-1431)、 聚氧乙烯烷基芳基醚 (Polyoxyethylene Alkyl Aryle Ether, Atlas G-1690) ' 聚氧乙烯單月桂酸醋（Polyoxyethylene Monolaurate， S-307)、聚氧乙稀單月桂酸醋（Polyoxyethylene Monolaurate, P.E.G· 400 Monolurate)、聚氧乙稀月 桂醚（Polyoxyethylene Lauryl Ether，Atlas G-2133)、 聚氧乙浠蓖麻油（Polyoxyethylene Castor Oil, Atlas G-l 794)、聚氧乙烯植物油（Polyoxyethylene Vegetable Oil, Emulphor EL-719)、聚氧乙稀（4EO) 失水山梨醇單月桂酸酉旨（Polyoxyethylene Sorbitan Monolaurate，Tween 21)、混和脂肪酸和樹脂酸的聚 氧乙稀醋類（Polyoxyethylene Esters of Mixed Fatty and Resin Acid，Renex 20)、聚氧乙稀山梨醇羊毛脂 衍生物（Polyoxyethylene Sorbitol Lanolin 23 200914063 Derivative，Atlas G-1441)、聚氧乙晞（24EO)膽固醇 醚（P.O.E.(24) Cholesterol, Solulan C-24)、聚氧丙烯 (20PO)羊毛醇醚（P.O.P.(20) Lanolin Alcohol, Solulan PB-20)、聚氧乙烯失水山梨醇單月桂酸酯 (Polyoxyethylene Sotbitan Monolaurat, Atlas G-7596j)、聚氧乙烯（20EO)失水山梨醇單硬脂酸酯 (Polyoxyethylene Sorbitan Monostearate, Tween 60)、聚氧乙烯（20EO)油醇醚（P.O.E.(20) Oleyl Alcohol, Ameroxol OE-20)、聚氧乙稀（20EO)曱基葡 萄糖苦倍半油酸酯（P.O.E.(20) Glucamate SS， Glucamate SSE-20)、聚氧乙烯（16EO)羊毛醇醚 (P.O.E.(16) Lanolin Alcohol, Solulan 16)、聚氧乙烯 (25EO)羊毛醇醚（P.O.E.(25) Lanolin Alcohol, Solulan 25)、聚氧乙烯（9EO)乙酸化羊毛脂衍生物 (Acetylated P.O.E.(20) Lanolin Derivative, Solulan 97)、聚氧乙烯（20EO)失水山梨醇單油酸酯 (Polyoxyethylene Sorbitan Monostearate, Tween 80)、聚氧乙烯單硬脂酸醋（Polyoxyethylene Monostearat, Myrj 49)、聚氧乙稀單油酸酯 (Polyoxyethylene Monooleate，Altlas G-2144)、聚氧 乙稀油基醚（Polyoxyethylene Oleyl Ether, Atlas G-3915)、聚氧乙稀十八醇（p〇ly〇xyethylene Stearyl Alcohol, Atlas G-3720)、聚氧乙烯油醇 24 200914063 (Polyoxyethylene Oleyl Alcohol，Atlas G-3920)、聚 氧乙烯脂肪醇（Polyoxyethylene Fatty Alcohol, Emulphor ON-870)、聚乙二醇單棕櫚酸酯 (Polyoxyethylene Glycol Monopalmitate, Atlas G-2079)、聚氧乙烯（20EO)失水山梨醇單棕櫚酸酯 (Polyoxyethylene Sorbitan Monopalmitate, Tween 40)、聚氧乙烯十六烧基醇（Polyoxyethylene Cetyl Alcohol, Atlas G-3820)、聚氧乙烯氧丙烯硬脂酸酯 (Polyoxyethylene Oxypropylene Stearate, Atlas G_2162)、聚氧乙烯山梨醇羊毛脂衍生物 (Polyoxyethylene Sorbitan Lanolin Derivative, Atlas G-1741)、聚氧乙烯單硬脂酸醋（Polyoxyethylene Monostearate, Myrj 51)、聚氧乙烯失水山梨醇單月 桂酸醋（Polyoxyethylene Sorbitan Monolaurate, Atlas G-7596P)、 聚氧乙烯單月桂酸酯 (Polyoxyethylene Monolaurate, Atlas G-2129)、聚氧 乙稀油基鍵（Polyoxyethylene Oleyl Ether，Atlas G-3930)等其中之一。 5.如申請專利範圍第一項所述利用奈米乳液來包覆多 酚類衍生物的方法，其中脂質成分包括磷脂類 (Phospholipids)、甘油醋類（Glycerolipids)、鞘脂類 (Sphingolipids)、jk 聚（Plasmalogens )、膽固醇 25 200914063 (Cholesterols )、脂肪酸（Fatty acids )等其中之一， 6. 如申請專利範圍第一項所述利用奈米乳液來包覆多 酚類衍生物的方法，其中該具官能基脂質之官能基 包括磷脂酸（Phosphatidic acid, PA)、膽驗填脂（礙 脂醢膽驗）（Phosphatidylcholine, lecithin, PC)、填脂 醯絲胺酸（Phosphatidylserine，PS)、腦磷脂（磷脂 醯乙醇胺）（Phosphatidylethanolamine, PE )、肌 醇填脂 （Phosphatidylinositol, PI) 、N-己胺 (N-Caproylamine) 、 N-十二烧基胺（N-Dodecanylamin、N-琥珀酸基（N-Succinyl)、N-戊二 基（N-Glutaryl)、N-十二欲基（N-Dodecanyl)、N-生物 素基(N-Biotinyl)、覆蓋 N-生物素基（N-Biotinyl Cap) 等其中之一， 7. 如申請專利範圍第一項所述利用奈米乳液來包覆多 酚類衍生物的方法，以頻率2kHz〜50MHz超音波震 盪數分鐘〜數十分鐘，即可製備圖（二）透明均勻 奈米乳液，可穩定至少6個月以上。 26200914063 13. Moisture in the nanoemulsion (mM) Nanoparticle size (nm) 15. Volume fraction (%) 16. Penetration of the skin, square centimeters (η〆 -累积. Cumulative time of penetrating the skin (hours) X. Patent application scope 1. The features of the present invention are as follows: (1) The surfactants of the composition are all biomedical compatible materials, because the auxiliary interface activity of the alcohol is not required to be added. The agent can be administered to the human body by transdermal, oral and injection; (2) the interface layer is protected to enhance the stability of the polyphenol derivative, and the oil phase can improve the solubility of the polyphenol derivative; (3) the nanoemulsion Improve the solubility of the drug, and carry more drug delivery than traditional emulsions or creams; (4) After dilution with a suitable phosphate buffered saline solution of 74 to 74, it can be stabilized for more than 2 days, giving it a better chance of being Physiological absorption and utilization; (5) The particle size of the nanoemulsion ranges from 5 to 100 nanometers (nm), which is easy to penetrate the skin into the microvessels of the subcutaneous tissue, which can improve the utilization rate of the organism; (6) Preparation The method is simple, with a frequency of 2 kHz to 50 MHz The sonic emulsion is suitable for the time. The preparation method of the nano emulsion includes: a variety of edible oils and fats 200914063 A surfactant having an HLB greater than 1 and a supersonic wave 2. The use of the first item of the patent application scope Polyphenol derivatives include Curcumin, Astaxanthin, Lycopene, Lutein, Zeaxanthin, Radix Puerariae, and Resveratrol ( Resveratrol), Proanthocyanidins, Bioflavonoids, Lignans, Flavoniods, Tannin, Apigenin, Luteolin, Rutin ), Cis-polyphenol (Hesperidin), Oleuropein, tyrosol, Cacao Polyphenol, Capsaicin, Chlorophyl, Ephedrin, Allicin (Allicin), Luteolin, Pueraria PE, Daidzein, Daidzin, Agrimophol, Alpinetin, Anthocyanosides, Apiin, Atractylon, Bakuchiol, Bergapol, Ginkgo 7-Demethyl 200914063 Ginkgo Biloba ( Bilobetin), Bisdemethoxycurcumin, Capsanthin, Capsicum Extract, Capsorubin, Carthamidin, Chrysophanol, Curcuma Curcumol, Curdione, Demethoxy-curcumin, Eugenol, Flavonoids, Ginkgo Biloba Extract, Gossypol , and Honokiol, Humulone, Isobavachin, Isoflavones, Kudzu P.E, Magnolol, Sulfhydryl Otto dihydrogen isoflavone A, B (Methylophiopogonanone A, B), Ophiopogon, A (B), Ophiopogonanone A (B), Ophiopogonone A, B (Ophiopogonone A, B), Dan Pioneol, purple Phenolic Compounds, Pogostone, 1 Polypheno, Pueraria Flavonid, Pueraria Root PE, Puerarin, Qingdainone, Resveratrol, Resveratrol 10 200914063 (Rhapontisterone), Rhein, Soy bean PE, Tanshinone IIA, Tanshinone I (Tanshinone IIA) Tanshinone I), Tanshinone IIB, Tea Polyphenol, Total Ginkgo Flavone-Glycoides, Turmeric PE, Turmerone, Arturmerone . 3. A method for coating a polyphenol derivative by using a nanoemulsion as described in the first paragraph of the patent application, wherein an edible fat or oil is an unsaturated fatty acid (the C22 carbon chain contains at least one (inclusive) or more Oils and fats with less than C14 carbon chain include, including: Seamy Seed oil, Almond Sweet oil, Avocado Oil, Borage Oil ), Evening primrose Oil, Hazelnut Oil, J〇j〇ba Oil, Olive Oil, R0se Hip Seed Oil, Sunflower Oil, Safflower Oil, Walnut Oil, Apricot Kernel Oil, Canola Oil, Rapeseed Oil, Castor Oil Oil), Camelina Oil, Apeseed Oil, Wheatgerm Oil, Queensland Nut Oil (Macadamia Oil) 200914063 (Macadamia Oil), Peanut Oil (Peanut Oil), Coconut Oil ( Coconut Oil), Cocoa Butter Cocoa Butter), Shea Butter, Carotino Premium Oil, Ethyl Oleate, Germ Oil, Palm Oil, Corn Oil ( Corn Oil), Hemp Oil, Raspberry Seed Oil, Cranberry Seed Oil, Pumpkin Seed Oil, Pistachio Nut Oil , Camellia Oil, Camellia Seed Oil, Soybean Oil, Canola Oil, Castor Oil, Hydrogenated, Lanolin oleic acid Oleic Acid), Polyoxyethylene Stearates, Polyvinyl Acetate Phthalate, Propyl Gallate, Simethicone, Hydrogenation Vegetable oil (Hydrogenated), argonized vegetable oil (Suppository Bases, HardFat), Peppermint Oil, Isopropyl Myristate (IPM), etc., 4· If you apply for a special The method of coating a polyphenol derivative by using a nano emulsion according to the first item, wherein the interface 12 200914063 having an HLB value of 1 comprises: ethylene oxide, propylene oxide, ethylene oxide (PEO-PPO-PEO) Copolymer Polyether Series (-(PPO)a (PEO)b (PPO)a- ) 'PEG-8 Monostearate, PEG-8 Laurel Ether ( PEG-8 Laurylether), Oteic Acid, Sorbitan Tribleate (Span 85), Sorbitan Trioleate (Arlacel 85), Polyoxyethylene Yam Polyoxyethylene Sorbitol Beeswax Derivative (Atlas G-1706), Sobibitan Tristearate (Span 65), Sorbitan Tristearate, Arlacel 65 ), Polyoxyethylene Sorbitol Hexastearate (Atlas G-1050), Ethyleneglycol Fatty Acid Ester (Emcol EO-50), Ethyleneglycol Fatty Acid Ester, Emcol ES-50), polyoxyethylene sorbitol bee Polyoxyethylene Sorbitol Beeswax Derivative (Atlas G-1704), Propylene Glycol Fatty Acid Ester (Emcol PO-50), Propylene Glycol Fatty Acid Ester, Atlas G-922 ), Propylene Glycol Fatty Acid Ester, Propylene Glycol Fatty Acid Ester, Atlas G-2158, Ethylene Glycol Fatty 13 200914063 Acid Ester, Emcol PS-50), Ethyleneglycol Fatty Acid Ester (Emcol EL-50), Propylene Glycol Fatty Acid Ester (Emcol PP-50), sorbitan sesquioleate ( Sorbitan Sesquioleate, Arlacel C), Sorbitan Sesquiolate (Arlacel 83), Polyoxyethyle Esorbitol 4 (5 Oleate, Atlas G-2859), Glycerol Monostearate Monostearate, Atmul 67), Glycol Distearate, Sorbitan Trioleate, Stearic Acid Glycol Stearate, Sorbitan Tristearate, Glyceryl Oleate, Sucrose Distearate, Polyoxyethylene Sorbitan Polyoxyethylene Sorbitol Hexastearate, Sortitan Sesquioleate, Polyoxyethyle Esorbitol 4.5 Oleate, Glycerol Monostearate, PEG-5 Castor Oil, Lanolin, Lanolin Alcohol, Cholesterol, Polyoxyethylene Sorbitol Beeswax, sorbitan monooleate (Sorbitan Monooleate), sorbitan oleic acid (Sorbitan Oleate), PEG-2 hard vinegar (PEG-2 14 200914063 Stearate), sorbitan sorbitan (Sorbitan Stearate), dehydration Sorbitol Isostearate, Steareth-2, PEG-7 Hydrogenated Castor Oil, Oil Alcohol-2 (01eth-2), PEG-4 di oil Acid ester (PEG-4 Dioleate), sorbitan palmitate, oil oxime-3 (01eth-3), lanolin-(n) (Laneth-(n)), mono-hard fat Glycerol Monostearate (Atmul 84), Glycerol monostee (Rateglycerol Monostearate, Tegin 515), Glycerol Monostearate (Aldo 33), glyceryl monostearate ( Pure Hydroxylatedlanolin), Ohlan Polyoxyethylene Sorbitol Beeswax, Arias G-1727 Derivative, Propylene Glycol Fatty Acid Ester, Emcol PM-50, Dehydration Sorbitol Monooleate (Span 80), sorbitan Monooleate (Arlacel 80), Propylene Glycol Monolaurate (Atlas G-917), Propylene Glycol Single Laurel Propylene Glycol Monolaurate (Atlas G-3851), Propylene Glycol Fatty Acid Ester (EmcolPL-50), sorbitan monostearate (Sorbitan Monostearate) ,Span 60), sorbitan 15 200914063 Sorbitan Monostearate (Arlacel 60), Diethylene Glycol Monooleat (Atlas G-2139), Diethylene Glycol Fatty Acid S (Diethylene Glycol Fatty Acid Ester, Emcol DO-50), Diethylene Glycol Monostearate (Atlas G-2146), Diethylene Glycol Fatty Acid Ester, Emcol DS-50 ), polyoxyethylene (2EO) oleyl ether (POE (2) Oleylalcohol, Ameroxol OE-2), polyoxyethylene Sorbitol Beeswax Derivative (Atlas G-1702), diethylene glycol fatty acid Diethylene Glycol Fatty Acid Ester (Emcol DP, 50), Glycerol Monostearate (Aldo 28), Tegin Glycerol Monostearate, Diethylene Glycol Fatty Acid Ester, Emcol DM-50), Methyl Glucoside Seequisterate (Glucate-SS), Polyoxyethylene Sorbitol Bee Pollen Derivative (Poly Oxyethylene Sorbitol Beeswax Derivative, Atlas G-l725), Diethylene Glycol Monolaurate (Atlas G-2124), Diethylene Glycol Fatty Acid Ester, Emcol DL_50, Diethylene Glaurin Diethylene Glycol Monolaurate, Lost Water Mountain 16 200914063 Sorbitan Monopalmitate (Span 40), Sorbitan Monopalmitate (Arlacel 40), Polyoxygen Polyoxyethylene dioleate (Atlas G-2242), Tetraethylene Glycol Monostearate (Atlas G-2147), Tetraethylene Glycol Mbnooleat, Atlas G -2140), polyoxypropylene mannitol dioleic acid vinegar (Volvoxvlropylene Mannitoldioleate, Atlas G-2800), polyoxyethylene Sorbitol Lanolin Derivative (Atlas G-1425), polyoxypropylene (5PO) ) lanolin ether (Splulan PB-5 P.0.P(5) Laolin Alcohol), sorbitan monolaurate (Sorbitan Monolaurate, Span 20) Polyoxyethylene Sorbitan Trioleate (Tween 85), Polyethylene Glycol 400 Monostearate, Polyoxyethylene (20) sorbitan Sodium stearate (Polysorbate 60, Tween 60), Polyoxyethylene Monostearate (Myrj 49), Polysorbate 20, Tween 20, Pure Lauryl Sulfate Pure Sodium Lauryl Sulfate, N-cetyl N-ethyl Morpholinium Ethosulfate, Potassium Oleate, Sodium Oleate, 17 200914063 PEG-90 Apricot Kernel Glycerides, PEG-40 Stearate, (12-13 Palmitol Ether-23) (: 12-13?&; Add 11-23),? £〇-100 Stearate, Alkyl Aryl Sulfonate, Sucrose Stearate (and) Sucrose Distearate , Triethanolamine Oleate, Oleth-lO, PEG-35 Castor Oil, PEG-40 Hydrogenated Castor Oil, PEG-40 Castor Oil, PEG-8 lauric acid vinegar (PEG-8 Laurate), lauric acid sarcosine (Lauroyl Sarcosine), PEG-6 GTCC glycerol g (PEG-6 Capprylic, Capric Glycerides), Ceteareth-12, PEG-15 Gluceryl Laurate, PEG-12 Stearate, PEG-24 Alcohol ether (PEG-24 Cholesterol), PPG-20 Lanolin Alcohol, PEG.40/45 Hydrogenated Castor Oil, PEG-60 Almond Oil Glycerin ( And) PEG-60 (Almond Glycerides (and) PEG-6GTCC) 'Caprylic/Capric Glycerides, Sucrose Stearate, PE G-60 Hydrogenated castor oil (PEG-60 Hydrogenated Castor Oil), PEG-20 sorbitan stearin 18 200914063 Acid sorbate (Polysorbate 60), PEG-20 sorbitan oleic acid oleic acid (Polysorbate 80), PEG- 60 PEG-60 Almond Glycerides, PEG-42 Babassu Glycerides, PEG-60 Evening Primrose Glycerides, PEG-45 Corn Glycerides (PEG-45 Corn Glycerides), PEG-45 Palm Kernel Glycerides, PEG-60 Maracuja Glycerides (PEG-60 Maracuja Glycerides), PEG-20 methyl glucoside sesquioleate Ester (PEG-20 Glucamate SS), succinyl ether-20 (Steareth-20), oleyl ether-20 (01eth-20), stearyl ether-21 (Steareth-21), PEG-20 dehydration Polysorbate 40, Ceteareth-20, PEG-20 Stearate, PEG-75 Lanolin, PEG-75 Lanolin Ceteareth-25, PEG-20 Polysorbate 20, Polyoxypropylene St Earate), PEG-5 Lanolin Alcohol, PEG-15 Castor Oil, PEG-8 Dioleate (PEG-8 Dioleate), sorbitan lauric acid Sorbitan Laurate, oleyl ether-5 (01eth-5), polyglyceryl-3 polyricinoleate, polyoxyethylene Oxypropylene Oleate, four Ethylene glycol 19 200914063 Tetraethylene Glycol Monolaurate, C12-13 Palmeether-4 (C12-13 Pareth-4), Polyoxyethylene Lauryl Ether, Hexaethylene glycol monostearate Hoxaethylene Glycol Monostearate, Cocoyl Sarcosine, Ceteareth-6, PPG-5 Laolin Alcohol, Recorded Alcohol Ether-5 (and) recorded stearyl ether-7 (Ceteth-5 (and) Ceteareth-7), polyoxyethylene Cetyl Ether, PEG-20 sorbitan tristearyl PEG-20 Sorbitan Tristearate, PEG-7 Glyceryl Cocoate, self-emulsifying stearic acid Glyceryl Stearate (S/E), PEG-8 Stearerate (PEG-8 Stearate), Stearic Acid Glycerin S (and) PEG 100 Stearic Acid S (Glyceryl Stearate (and) PEG 100 Stearate), PEG-20 sorbitan sorbate (Polysorbate 85), polyoxyethylene oxy oxy oleic acid (Polyoxyethylene Oxypropylene Oleate), PEG-8 laurel glycerin (PEG-8 Glyceryl Laurate), PEG-8 Stearate, PEG-29 Castor Oil, Polyoxyethylene Lauryl Rther (Brij 35), Polyoxyethylene Monostearate Polyoxyethylene monolaurate (Myrj 52), Polyoxyethylene Monolaurate (Myrj 53), Polyoxyethylene 20 200914063 Polyoxyethylene Monolaurate (Atlas G-2159), Polyoxyethylene Polyoxyet Hylene Sorbitol Lanolin Oleate Derivative (Atlas G-1493), Polyoxyethylene Sorbitol Lanolin (Atlas G-1425 derivative), Polyoxypropylene Stearate (Polyoxypropylene Steara Te, Atlas G-3608), polyoxyethylene (5EO) lanolin ether (POE (5) Lanolin Alcohol, Solulan 5), sorbitan lauric acid (Sorbitan Monolaurate, Arlacel 20), polyoxyethylene fatty acid (Polyoxyethylene) Fatty Acid, Emulphor VN-430), Polyoxyethylene Oxypropylene Oleate (Atbs G-2111), Polyoxythylene Sorbitol Beeswax Derivative, Atlas G-l734 , Tetraethylene Glycol Monolaurate (Atlas G-2125) 'Polyoxyethylene Lauryl Ether (Brij 30), oxyethylene (4EO) sorbitan monostearate ( Polyoxethylene Sorbitan Monostearate, Tween 61) 'Hoxaethylene Glycol Monostearate (Atlas G-2154), Polyoxypropylene (5PO) Lanolin Ether (P.0.P(5) Laolin Alcohol, Splulan PB-5), polyoxyethylene (5EO) sorbitan monooleate (Polyoxyethylene 21 200914063 Sorbitan Monooleate, Tween 81), mixed fatty acid and resin acid polyoxyethylene ester (Polyoxyethyle Ne Esters of Mixed Fatty and Resin Acids, Atlas G-1218), Polyoxyethylene Cetyl Ether (Atlas G-3806), Polyoxyethylene (20EO) sorbitan tristearate ( Polyoxyethylene Sorbitan Tristearate, Tween 65), Polyoxyethylene Lauryl Ether (Atlas G-3705), Polyoxyethylene (20EO), Polyoxyethylene Sorbitan Trioleate (Tween 85), Poly Polyoxyethylene Oxypropylene Oleate (Atlas G-2116), Polyoxyethylene Lanolin Derivative (Atlas G-1790), Polyoxyethylene Monooleate , Atlas G-2142), Polyoxyethylene Monostearate (Myrj 45), Polyoxyethylene Enemonooleate (Atlas G-2141), Polyoxyethylene Monooleate (Polyoxyethylene) Monooleate, PEG400 Monooleate), Polyoxyethylene Monopalmitate (Atlas G-2076), Polyoxyethylene Monostearate (Polyo) Xyethylene Monostearate, S-541), Polyoxyethylene Monostearate (PEG400 Monostearate), Acryl Aryl 22 200914063 Sulfonate, Atlas G-3300, Triethanolamine Oleic Acid Triethanolamine Oleate, Polyoxyethylene (10EO) oleyl ether (Ρ.Ο.Ε·(10) Oleyl Alcohol, Ameroxl OE-10), Polyoxyethylene Monolaurate (Atlas G-2127) , Polyoxyethylene Alkyl Phonol (Igepal CA-630), Polyoxyethylene (10EO) Acetylated Lanolin Derivative (Acetylated POE (IO) Landin Derivative, Solulan 98), Polyoxyethylene Sorbitol Polyoxyethylene Sorbitol Landing Derivative (Atlas G-1431), Polyoxyethylene Alkyl Aryle Ether (Atlas G-1690) 'Polyoxyethylene Monolaurate (S-307) ), Polyoxyethylene Monolaurate (PEG 400 Monolurate), Polyoxyethylene Lauryl Ether (Atlas G-2133), Polyoxygen Castor oil (Polyoxyethylene Castor Oil, Atlas Gl 794), Polyoxyethylene Vegetable Oil (Emulphor EL-719), Polyoxyethylene (4EO) sorbitan monolaurate (Polyoxyethylene Sorbitan Monolaurate, Tween) 21) Polyoxyethylene Esters of Mixed Fatty and Resin Acid (Renex 20), Polyoxyethylene Sorbitol Lanolin 23 200914063 Derivative, Atlas G- 1441), polyoxyethylene oxime (24EO) cholesterol ether (POE (24) Cholesterol, Solulan C-24), polyoxypropylene (20PO) lanolin ether (POP (20) Lanolin Alcohol, Solulan PB-20), polyoxygen Polyoxyethylene Sotbitan Monolaurat (Atlas G-7596j), Polyoxyethylene Sorbitan Monostearate (Tween 60), Polyoxyethylene (20EO) Oleyl ether (POE (20) Oleyl Alcohol, Ameroxol OE-20), polyoxyethylene (20EO) thioglucan sesquioleate (POE (20) Glucamate SS, Gl Ucamate SSE-20), polyoxyethylene (16EO) lanolin ether (POE (16) Lanolin Alcohol, Solulan 16), polyoxyethylene (25EO) lanolin ether (POE (25) Lanolin Alcohol, Solulan 25), polyoxygen Ethylene (9EO) acetate lanolin derivative (Acetylated POE (20) Lanolin Derivative, Solulan 97), polyoxyethylene (20EO) sorbitan monooleate (Polyoxyethylene Sorbitan Monostearate, Tween 80), polyoxyethylene single Polyoxyethylene Monostearat (Myrj 49), Polyoxyethylene Monooleate (Altlas G-2144), Polyoxyethylene Oleyl Ether (Atlas G-3915), Polyoxygen Ethyl stearyl alcohol (p〇ly〇xyethylene Stearyl Alcohol, Atlas G-3720), polyoxyethylene oleyl alcohol 24 200914063 (Polyoxyethylene Oleyl Alcohol, Atlas G-3920), polyoxyethylene fatty alcohol (Polyoxyethylene Fatty Alcohol, Emulphor ON -870), Polyoxyethylene Glycol Monopalmitate (Atlas G-2079), Polyoxyethylene (20EO), Polyoxyethylene Sorbitan Monopalmitate, Twe En 40), Polyoxyethylene Cetyl Alcohol (Atlas G-3820), Polyoxyethylene Oxypropylene Stearate (Atlas G_2162), Polyoxyethylene Sorbitol Lanolin Derivative (Polyoxyethylene Sorbitan Lanolin Derivative, Atlas G-1741), Polyoxyethylene Monostearate (Myrj 51), Polyoxyethylene Sorbitan Monolaurate (Atlas G-7596P), One of polyoxyethylene monolaurate (Atlas G-2129) and polyoxyethylene Oleyl Ether (Atlas G-3930). 5. A method of coating a polyphenol derivative with a nanoemulsion according to the first aspect of the patent application, wherein the lipid component comprises Phospholipids, Glycerolipids, Sphingolipids, Jk poly (Plasmalogens), cholesterol 25 200914063 (Cholesterols), fatty acids (Fatty acids), etc., 6. The method of coating a polyphenol derivative with a nanoemulsion as described in the first paragraph of the patent application, wherein The functional group of the functional lipid includes phosphatidic acid (PA), phlegm-filled fat (Phosphatidylcholine, lecithin, PC), phlegacidylserine (PS), brain Phosphatidylethanolamine (PE), Phosphatidylinositol (PI), N-Caproylamine, N-Dodecanylamin, N-succinic acid ( N-Succinyl), N-Glutaryl, N-Dodecanyl, N-Biotinyl, N-Biotinyl Cap ) and so on, 7. Please use the method of coating the polyphenol derivative with nano-emulsion as described in the first paragraph of the patent, and prepare the image (2) transparent uniform nano-emulsion by ultrasonic vibration at a frequency of 2 kHz to 50 MHz for several minutes to several tens of minutes. , can be stable for at least 6 months. 26