TW200824744A - Integrated coil apparatus and method for using same - Google Patents

Integrated coil apparatus and method for using same Download PDF

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TW200824744A
TW200824744A TW95147008A TW95147008A TW200824744A TW 200824744 A TW200824744 A TW 200824744A TW 95147008 A TW95147008 A TW 95147008A TW 95147008 A TW95147008 A TW 95147008A TW 200824744 A TW200824744 A TW 200824744A
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Taiwan
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electromagnetic
humans
animals
treatment
waveform
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TW95147008A
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Chinese (zh)
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Arthur A Pilla
Andre A Dimino
Lyer Viswanathan
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Ivivi Technologies Inc
Arthur A Pilla
Andre A Dimino
Lyer Viswanathan
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Priority to TW95147008A priority Critical patent/TW200824744A/en
Publication of TW200824744A publication Critical patent/TW200824744A/en

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Abstract

An apparatus and method for electromagnetic treatment for treatment of molecules, cells, tissues, and organs comprising: configuring at least one waveform according to a mathematical model having at least one waveform parameter, said at least one waveform to be coupled to a target pathway structure (STEP 101); choosing a value of said at least one waveform parameter so that said at least waveform is configured to be detectable in said target pathway structure above background activity in said target pathway structure (STEP 102); generating an electromagnetic signal from said configured at least one waveform(STEP 103); integrating at least one coupling device with a positioning device to be placed in proximity to said target pathway structure(STEP 104); and coupling said electromagnetic signal to said target pathway structure using a coupling device(STEP 105).

Description

200824744 TPPO/PUS213-001 九、發明說明: 【發明所屬之技術領域】 、本案為-種整合_裝奴及紐,尤減磁式治雜合線圈裝 置以及方法’藉由應用編碼電磁資訊達成細胞和組織成長調整、修復、 隹k身又行為本木尤其疋關於外科上非侵入性地將電磁信號K 、」何數目的身體刀結合之應用。本案亦關於經由改變活組織和細 屬胞與其電磁環境之交互作_治療方法。本案更關於經由躺編碼電 磁貧訊進行__職成翻整、修復、維護,以及—般行為的一種 ㈣的疋本木提出一具體實施例,此實施例根據目前的發明, 使用感應方式(如線圈)傳遞脈衝電磁場("腿以強化活組織成 其他元件如支制、纏繞物、床、輪椅,並 結合其它有療效且健康之物理療法,譬 熱、冷、按摩等。 【先前技術 . &應用被弱非熱兒磁場(EMF )產生有生理學意義的活體内和試 管内生物效應已發展完備。 、,-哪_骨__合之翻。含有低解組成和低功 τ ^療。骨路修復信號的使用係源於 考慮]ι軸:可ι構成_個使骨财以合適地對應至腿信號的方 式。一使用細胞膜電化學模型的線性物理化學方法預測了可能的生物 5 200824744 TPPO/PUS213-001 效應之EMF波形樣式的範圍。由於細胞膜為可能為哪的―目炉,所 以必纖到-個可用電化學方式結合在細胞表面上的誘發電叙;波形 參數範圍,如電壓依附性的動力學。此線性模式的延伸也涉及羅偷兹 力分析。 由27.12馳連續正弦波傳遞的一脈衝無線電波頻率(闕使 用在深度活組織的癒合,已在先前的電療技術上廣為所知。電雜號 ^的一脈衝承繼起初被認為是感染治療中能引起非熱生物學效應的電磁 蘑場。P㈣療已知應用在減低創傷及手術前疼痛以及在軟組織、傷口 癒合、燒傷治療和神經再造中減少浮腫。膽驗解決創傷浮腫在近 年來已經廣泛使用。至今PRF用在動物及臨床研究上指出經由這樣的 電磁刺激,可使浮腫大為降低。 先前的-劑量學技術並未考慮組織結構的介電性質相對於獨立 細胞的介電性質之關係。 近年來,臨床上在無線電波頻段的非侵入式pRp之使用,包含使 •用权I2 MHz正弦波的脈衝突發,其中每個脈衝突發包含65微秒 的見度’制固犬發約有1700個正弦循環,且有不同的重複率。此受限 的頻率組成可以與細胞和組織中有關的介電路徑結合。 時魏磁場-包含方波、擬方波、或兼具方波和擬方波之波形,如 _調變電磁場;以及正弦波形,如麵無線電頻率場(綱由_200824744 TPPO/PUS213-001 IX. Description of the invention: [Technical field of invention] This case is an integration--slave and new, special reduction magnetic hybrid coil device and method 'to achieve cell by applying electromagnetic information And the organization of growth adjustment, repair, 隹k body and behavior of the wood, especially the application of non-invasively combined electromagnetic signals K, "the number of body knives. This case also deals with the treatment of the interaction between the living tissue and the cells and their electromagnetic environment. In this case, a specific embodiment is proposed in the case of a fourth (fourth) squatting, repairing, maintaining, and general behavior of a lie-coded electromagnetic dysfunction. This embodiment uses an inductive method according to the current invention ( Such as coils) transmit pulsed electromagnetic fields (" legs to strengthen the living tissue into other components such as support, windings, beds, wheelchairs, and in combination with other curative and healthy physical therapies, heat, cold, massage, etc. [Prior Art &Applications have been developed by the weak non-thermal magnetic field (EMF) to produce physiologically significant in vivo and in vitro biological effects. ,,,,,,,,,,,,,,,,,,,,,, The use of the bone repair signal stems from the consideration of the ι axis: ι ι constituting a way to properly correspond to the leg signal. A linear physicochemical method using cell membrane electrochemical models predicts possible Bio 5 200824744 TPPO/PUS213-001 The range of EMF waveform patterns of effect. Because the cell membrane is the possible "mesh furnace", it must be induced by an electrochemical method on the cell surface. The range of waveform parameters, such as the dynamics of voltage dependence. The extension of this linear mode also involves the analysis of the force of a pulse. The frequency of a pulse of radio waves transmitted by a continuous sine wave of 27.12 is used in the healing of deep biopsies. It has been widely known in previous electrotherapy techniques. The pulse of the electroacoustic number ^ was originally thought to be an electromagnetic mushroom field that can cause non-thermal biological effects in infection therapy. P (four) therapy is known to be used in reducing trauma and surgery. Pain and reduction of edema in soft tissue, wound healing, burn treatment and nerve reconstruction. The use of biliary examination for traumatic edema has been widely used in recent years. PRF has been used in animal and clinical research to point out that edema can be made through such electromagnetic stimulation. The previous-dosimetry technique did not consider the relationship between the dielectric properties of the tissue structure and the dielectric properties of the independent cells. In recent years, the use of non-invasive pRp in the radio wave band clinically, including the right to use I2 MHz sine wave burst, where each burst contains 65 microseconds of visibility. The fixed dog has about 1700 sinusoidal cycles. And there are different repetition rates. This limited frequency composition can be combined with the relevant dielectric paths in cells and tissues. Time Wei magnetic field - contains square wave, square wave, or both square wave and square wave waveform, Such as _ modulation electromagnetic field; and sinusoidal waveform, such as surface radio frequency field (outline _

Hz _ 15至4OTz卜臨床上用作各麵肉骨路受傷狀況的附屬療法 很有幫助。 200824744 TPPO/PUS213-00! 從1960年代開始,現代治療和預防疾病的設備的發展是由臨床上 關於非合併和延遲合併骨頭的破裂問題所刺激。早期嫌表示,電子 路徑可以是-個讓骨頭能適應地對應於機械輸入的方法。早期的^療 設備使用了植入性的和半侵入性的電極傳遞直流電(τ)至一破裂 區剩又入f生的技術隨後被開發為使用電場和電磁場。這些療法起初 用來在細胞/組織等級提供誘發電/機械波形的非侵入性的"免接觸" ‘ 方式。這些技術的臨床應用在續形術方面經由全世界的破裂治療—如非 .鲁合併破裂和新的破裂的治療,以及脊椎接合—而得到改進。目前數個 —^療贿合破裂之鮮的設備。這些設 備的成功耗非料。歧義龍杜社觀触其被推薦 -個安全、非手術性、非侵人性的第—次骨·植之代替方法。這些 2術的其他臨麵示侧機血轉死的雙f魏研究、腱炎、骨關 即火、創傷修理、血液循環和關節炎疼痛以及其它肌肉骨騎害方面 的/台療法荨方面上已有報告。 、-1、且成的研究確定了微弱低頻率電磁場在信號轉導路徑及生長 因子合成的作用。研究顯示,在短暫的、似觸發性的期間之後,勝^ =長因子的分泌。離子/配位子在細胞膜的結合過程一般被認為是 EMF 0 , ^ 理上’是作為骨頭修復的正常分子調節部分之如同調變般的表現量择 加。 曰 Ί層級的研究顯示出在成骨細胞中,對娜子運輸、細胞擴散、 7 200824744 TPPO/PUS213-001 胰島素生長因子(n IGF-IΓ)釋放,和IGF-II受體的作用之表現。對胰 島素生長因子-I("IGF—Γ’)和IGF一Π的作用也被驗證在鼠的破裂假 骨質。以PEMF轉換生長因子beta (” TGF 一 β ”)訊息核糖核酸(” _A,,) 的刺激已在一個鼠的骨頭誘發模型中被揭示。研究結果並展示了 TGF -/3 mRNA經由定名為MG-63的人類似成骨細胞線而使表現量增 加’其中在TGF - /31、膠原、和骨約素合成方面有增量。pE疆^刺激 • 了人類的非聯合組織中肥大和萎縮細胞之TGF - /31的增量。進一步 ,春 的研究展示出因EMF在一條_/調妈素依賴性的路徑之直接效應而 導致的在TGF-/51 mRNA和成骨細胞培養的蛋白質之增量。軟骨細胞 研究顯示出在TGF-/31 _A和由EMF合成的蛋白質方面有相似的增 量’說明了一種關節修復的治療應用。各種研究指出,生長因子生產 的表現量增加,也許是一個潛在的組織層級機制電磁刺激的共同分 母。當使用特定抗化劑時,EMF可能通過一調鈣素依靠性的路徑。先 雨研究指出,特定PEMF和prf信號以及微弱的靜態磁場,在一種無 #細胞酵素製劑中會調整奶挪_結。另外,聰和騰*的趣 w 伴隨成骨細胞培養之表現量增加,和在骨頭及軟骨中的财—如伴隨 “著PEMF之表現量增加,已經被實驗所闡釋以及說明。 然而,先前技術在這個領域並不使用一個誘發裝置—根據數_ 型傳導信號的,可程式化的、輕量、便攜的、可抛棄的、可植入的、 ^可組成的、可内建的,或至少附於服裝、時裝配件、腳穿著物、端 帶、支持器、解剖纏繞物、服裝、坐墊、床墊、墊、輪椅、治療床、 8 200824744 TPPO/PUS213-001 治療椅、治療和健康維護設備如真空協助的創傷關閉設備、機械和功 能電子刺激設備和運動設備,或超聲波、熱、冷、按摩、和運動。對 於《式治療誘發裝置及其方法,更進一步的需求是輕量的、便攜的、 可植入的、和可拋棄式的。對於一個電磁式治療誘發裝置和方法,更 進-步的f求是具較少的神需要量和非侵人性的·,此特徵可允 許-個強化信號整合在外科包紮用品、創傷包紮、墊、坐塾、床塾、 鞋子、及合併至活組織和細胞的其他服裝或結構,甚至整合於服裝的 _創造中以傳遞強化的EMF信號至身體所有部分並根據數學模型傳遞 信號,且為可程式化的。 【發明内容】 本案之目的在於提出-整合於治療和非治療的設備之電磁式治療 誘發裝奴及-綠-騎經_發齡的雜餘_形以改變活 組織和細胞與其電磁環境互動之治療。 ⑩ 為達上述目的’本案提出一種具體實施例,經由對一個可選擇的 身體區域以-流量路徑處理,此流量路徑包括有一個極小的寬度特徵 其在-個脈衝突發封包中至少約請微秒,有著每突發約^約’ 100’000個脈衝,其中前述脈衝突發的電壓振幅封包由一個任意變化 的參數定義’其瞬間極小振幅不小於其s大振幅的一千分之十之比 例。脈衝突發重複率可從約0. 〇1至約1〇, _機。一個數學上可定 義的參數也可用來定義前述脈衝突發的振幅封包。 由增加傳送至相關的細胞路徑的頻率組成範圍,達到使大範圍的 200824744 TPPO/PUS213-001 生勿物理學的現象可適用於已知的癒合機制,包括增強__生和 生長因子和細胞激素釋放,使此目的能有利達成。 根據本案提出之具體實施例,由翻_個任意、或其它高波譜密 又的于匕對單極或雙極方形或正弦脈衝突發封包或誘發電場峰在 ’到10伏特每厘罐cm)的正弦脈衝,—個更有高效率和_想的 效果可在適用於人、動物和植物的軟和堅硬組織的生物癒合過程中達 成。有更南波譜密度的脈衝突發封包可有利並效率地與對生理相關的 >電介質路徑結合,如細胞膜受器、與細胞酵素的離子鍵結,和一般穿 膜電位的改變因此調整血管新生作用和新生血管 由有利地應用-個高波譜密度的封包作為調整或脈衝突發定義的 參量,對此調變脈衝突發之功率需要量能顯著地低於未調變脈衝。這 _細胞/分子過程的匹配更高效率。相應地,達 到對相關的電介質路徑增強傳送劑量與減少功率需要量的雙餅處。 本案之-雛實施例糊功率的信號雜訊比率(,,powers服,)方 I法配置生物效應敝形並合併小型化的電路和輕量的彈性的線圈。其 有利地使-設備可 Power SNR紐、小型化的電路,和輕量彈性 的線圈’可完全地便攜,且可依需要可做成可拋棄式和更進一步可依 需要做紐入式。該輕量彈性線圈可能是一個適當設備(譬如外科包 鞋子、輪椅、椅子、和其他服裝和 與活組織和細胞並至的結構)的-個整體部份。經由有效地整 進入-鶴當備,聊·著且校财式雜 200824744 TPPO/PUS213-001 治療。Hz _ 15 to 4 OTz is clinically useful as an adjunct to the treatment of various facial bone injuries. 200824744 TPPO/PUS213-00! Since the 1960s, the development of modern treatment and disease prevention devices has been stimulated by clinical rupture problems involving non-combined and delayed bone. Early suspicion indicates that the electronic path can be a method that allows the bone to adaptively correspond to mechanical input. Early electrotherapy devices used implantable and semi-invasive electrodes to deliver direct current (τ) to a rupture zone and then developed into electrical and electromagnetic fields. These therapies were originally used to provide a non-invasive "contactless" ‘induction of electrical/mechanical waveforms at the cell/tissue level. The clinical application of these techniques has been improved in continuum surgery through rupture treatments around the world, such as treatment of rupture and new rupture, and spinal joints. At present, there are several devices that treat bribes and ruptures. The power consumption of these devices is unpredictable. The ambiguous Longdu Club has been recommended to be a safe, non-surgical, non-invasive first-sub-bone-plant alternative. The other side of these 2 techniques showed side-by-side blood test, double-fertility study, tendonitis, bone closure, fire repair, blood circulation and arthritis pain, and other physiologic bones. There have been reports. The study of -1 and Chengcheng determined the role of weak low-frequency electromagnetic fields in signal transduction pathways and growth factor synthesis. Studies have shown that after a short, trigger-like period, win = long-term secretion. The binding process of the ion/coordination in the cell membrane is generally considered to be EMF 0 , which is a modulation-like expression of the normal molecular regulatory portion of bone repair.曰 Ί level studies have shown the role of neutrophil transport, cell diffusion, 7200824744 TPPO/PUS213-001 insulin growth factor (n IGF-IΓ) release, and IGF-II receptors in osteoblasts. The effect on insulin growth factor-I ("IGF-Γ') and IGF-inhibition was also verified in rat ruptured pseudo-osteogen. Stimulation of PEMF-converting growth factor beta ("TGF-β") message ribonucleic acid ("_A,") has been revealed in a rat bone-inducing model. The results show that TGF-/3 mRNA is designated by MG -63 people resemble osteoblast lines to increase the amount of expression's in which there is an increase in TGF-/31, collagen, and osteosynthesis synthesis. pE Xinjiang stimulates hypertrophy and atrophy in human non-combined tissues The increase in TGF-/31. Further, the spring study demonstrated an increase in protein in TGF-/51 mRNA and osteoblast cultures due to the direct effect of EMF in a _/pro-dependent pathway. The chondrocyte study showed a similar increase in TGF-/31 _A and proteins synthesized by EMF', indicating a therapeutic application for joint repair. Various studies have indicated that the production of growth factor production is increased, perhaps a Potential tissue-level mechanism Common denominator of electromagnetic stimulation. When using specific inhibitors, EMF may pass a calciton-dependent pathway. First rain studies indicate that specific PEMF and prf signals and weak static magnets In the field, in a non-cell enzyme preparation, the milk will be adjusted. In addition, the interesting w of Cong and Teng* is accompanied by an increase in the expression of osteoblast culture, and the wealth in the bones and cartilage—as with the “PEMF” The increase in performance has been explained and illustrated by experiments. However, the prior art does not use an inducing device in this field - a programmable, lightweight, portable, disposable, implantable, composable, built-in based on a number-type signal. , or at least attached to clothing, fashion accessories, foot wear, end belts, holders, anatomical windings, clothing, cushions, mattresses, pads, wheelchairs, treatment beds, 8 200824744 TPPO/PUS213-001 treatment chair, treatment And health maintenance equipment such as vacuum assisted wound closure devices, mechanical and functional electronic stimulation devices and exercise equipment, or ultrasound, heat, cold, massage, and exercise. Further demands for "therapeutic induction devices and methods thereof are lightweight, portable, implantable, and disposable. For an electromagnetic therapy-inducing device and method, a further step-by-step requirement is that there is less need for God and non-invasiveness. This feature allows for an enhanced signal integration in surgical dressing, wound dressing, padding. , sitting, mattresses, shoes, and other garments or structures incorporated into living tissue and cells, even integrated into the _ creation of clothing to deliver enhanced EMF signals to all parts of the body and transmit signals according to mathematical models, and Stylized. SUMMARY OF THE INVENTION The purpose of the present invention is to propose that the electromagnetic therapy integrated into the treatment and non-therapeutic apparatus induces slaves and - green-riding _ age-of-life _ shape to change the interaction between living tissue and cells and their electromagnetic environment. treatment. 10 In order to achieve the above object, a specific embodiment is proposed, which is processed by a flow path for an optional body region, the flow path comprising a minimum width characteristic which is at least approximately in the burst burst packet. Seconds, with about '100'000 pulses per burst, wherein the voltage amplitude envelope of the aforementioned burst is defined by an arbitrarily varying parameter 'its instantaneous minimum amplitude is not less than one tenth of its s large amplitude proportion. The pulse burst repetition rate can be from about 0. 〇1 to about 1 〇, _ machine. A mathematically definable parameter can also be used to define the amplitude envelope of the aforementioned burst of pulses. By increasing the frequency range of transmission to the relevant cellular pathways, a wide range of 200824744 TPPO/PUS213-001 physics can be applied to known healing mechanisms, including enhanced __ raw and growth factors and cytokines Release so that this purpose can be achieved. According to a specific embodiment proposed in the present case, the unipolar or bipolar square or sinusoidal pulse bursts or induced electric field peaks at 'to 10 volts per PCT tank cm' by arbitrarily or other high spectrally dense 匕. The sinusoidal pulse, a more efficient and imaginative effect, can be achieved in the healing process of soft and hard tissues suitable for humans, animals and plants. Pulse burst packets with a more southern spectral density can be advantageously and efficiently combined with physiologically relevant > dielectric pathways, such as cell membrane receptors, ionic bonding with cellular enzymes, and general transmembrane potential changes, thereby modulating angiogenesis The action and neovascularization are advantageously applied as a parameter of a high spectral density as a parameter defined by an adjustment or burst of pulses, the power requirement of which can be significantly lower than that of the unmodulated pulse. This _ cell/molecular process matches more efficiently. Accordingly, a double cake is added to the associated dielectric path to enhance the delivered dose and reduce the power requirement. In this case, the signal noise ratio (,, powers service) of the paste power of the embodiment is configured to combine the bio-effects with the miniaturized circuit and the lightweight elastic coil. It advantageously allows the device to be powered by a SNR, a miniaturized circuit, and a lightweight, flexible coil' that is fully portable and can be made disposable and further customizable as needed. The lightweight elastic coil may be an integral part of a suitable device (such as surgical bag shoes, wheelchairs, chairs, and other garments and structures that come into contact with living tissue and cells). Through the effective integration of the whole - crane as a preparation, chat and school finances mixed 200824744 TPPO / PUS213-001 treatment.

200微秒對稱或不對稱的脈衝重覆在約〇 1 内。犬發封包是一個調變的l/f函數且用在 1000赫茲間。 具體地’賴波_寬赠贿突發,配在-個生物目 標波段之觸最大錢裤’ _雛的朗杨雜官、组織、细 胞和分子的目標雜徑結構。使用單一的振幅/功率比較與一着 徑結構的齡減較喊微形。錄祕結具邱、長方形、混 脉任意波形的之-的突發’頻率内雜敎Qi顯至議兆赫 在約1至約100,000個突發/每秒,並有從約0.01至約1000個突發/ 母心的犬發重神L信號振幅在—個目標路徑結構(如組織)在 約wcm的範圍至moo mV/cm。各侧言號突發封包也許是一任意函 數,其提供-方法使癒合組織的各種不同的電磁式觸目容。本案所 提出之-較佳實施例包括約(Π至約⑽毫秒脈衝突發包括約i至約 至約100千赫在突發之 隨機重複率在約〇· 1和約 固定的重複率也可被用在約〇. i赫兹和約1〇〇〇赫兹之間。一個 誘發電場產生在約〇. 001 mV/απ至約⑽mV/cm。本案所提出之一另 -實施例包含-約〇. G1毫秒至約1G毫秒之高醉絲突發(譬如 27.12兆赫)’重_約i至約刚個突發/每秒。產生一個誘發電場 約〇. OOi mV/cm至約議mV/cm。產生的波形可能藉由電感或電容的 輕合而傳遞。 本發明另提出-種活細胞和組_電磁式治療方法,其包括一個 200824744 t頻 '高波譜密度的電磁場。 3 00 本發明更提出-種活細胞和組織的電磁式治療方法,且包括一+ =鳴細隱瓣,_魏精無胞或^ 甲敢大相關的EMF-敏感性路徑耦合。 =配置一經由麵號噪音比率c,snr”)分析之數學模擬的 波开補波譜’以配置一波形其可理想地調控血管新生和新生血管 個經波形組態裝置(如小型化的電子電路)提供能量 的輸出δ又備(如超輕量線圈)以麵合組態波形。 一本㈣提出一種輕量彈性線圈,其可是整合入至少下列其中之 /隨、時褒配件、腳穿著物、端帶、解剖支持器、解剖包紫物、 =坐塾、床墊、塾、輪椅、治絲、治療椅子、治療和健康維護 二。如真工協助的傷口麵設備、機械和魏電子刺激讀和東 矛匕糸’以傳遞理想的上述之最適宜的非侵入式電磁脈衝洛療的 劑置’以加強在動物、人和植物中活組織的修復和成長。 本發明另提出-方法傳遞由目標路徑結構的snr/p·分析配 置的波形’以可編程式的方式例如根據時間一劑量程式、一系列的脈 衝或其他隨機或設計的序列。 本發明另提出一方法以產生一由波形而來的信號,該波形由目標 =構_你败分析配置,以可絲柄_如根據時間— μ里知式、一系列的脈衝,或其他賴或設計的序列。 X月另提出-方法以提供多重線圈,傳遞由目標路徑結構的 12 200824744 TPPO/PUS213-001 SNR/Power分析配置的波形,以增加治療覆蓋區域。 本發明另提出-方法以提供多重線圈,該線圈為同時驅動或接續 驅動(例如多路通訊傳輸一般),以相同或不同的上述最佳组· 本發明更触-方纽韻難、輕魏制,魏酿由納入 線Μ焦EMF信號至受影響的組織,傳遞由對目標路徑結構的 SNR/P〇wer分析配置的波形’進入人體工程的支持服裝。 ' 本拥更提出-方法以運鱗線創造每日賴、和整合有線圈的 •活動運動服裝’傳遞由對目標路徑結構的SNR/Power分析配置的波 形,放置在與接近一個解剖目標的位置。 ,本發明更提出-方法以輕量彈性線圈或導線傳遞灘信號 至受影響的組織,經由合併此線圈或導線作為各種形_帶的整體部 /刀’备壓縮、彈性、冷的壓縮和熱的壓縮和傳遞由對目標雜結構 的SNR/Power分析配置的波形。 龜 本發明另提出一方法以使用數個線圈,由對目標路徑結構的 SNR/P0wer分析配置的傳遞波形’以增加跡覆蓋面區域。 "本發明另提出-方法以製作—線圈,使用導線,傳遞由一個目標 路徑結構的SNR/P〇wer分析配置的波形。 ^發明另提出-方法以製作—線圈,使用細彈性導線,傳遞由一 個目軚路棱結構的SNR/Power分析配置的波形。 本^ Θ另提出-方法以提供由目標路徑結構的SNR/p(·分析 配置的相同或不同的波形,同時或連續地供給單_或多重線圈。 13 200824744 TPPO/PUS213-001 傷治療-併被使用。 卜科創Θ包紮與標準的創 藉由使鶴方法持物.分開, 方式。 WU)、麵和所有其它臨時附著 s_本發0^—梅觀軸梅崎目標_構的 瓣I冰配置的波形,其整合在治療床、治療椅子,和輪椅。 方法以提供線圈其傳遞崎目標路徑結構的 s_〇wer雜配置的波形,其整合在各種各樣的療法表面,譬如壓 解除、可驗、流紐、轉性和空氣流細唭他支援的表面。 本么月另提出-方法以提供線圈其傳遞由對目標路經結構的 SNR/Power力析配置的波形,其整合在與治療坐塾例如可膨服、流體 化的、泡棉坐墊。 本發明另提出—方法以提供、_其傳遞由對目標路彳__ S^P〇Wer錄配置的波形,其整合在至少下列其中之-:治療床墊 覆蓋物、床單、毯子、枕頭、枕頭盒,減可能施加平穩或斷續的壓 力的治療言免備譬如空氣清除背心。 柄明另提出一方法以使通量路徑可包含在任一個治療表面、結 構’或設備’經由傳遞對目標路徑結構的SNR/p〇wer分析配置的波 14 200824744 / TPP_S213 姻 形,以提高該治療表面、結構或f臾備的效果。 本發明另提出一方法以將傳遞由對一個目標路經結構的 SNR/Power分析配置的波形之線圈,納入於腳穿著物學如鞋子。 本發明另提出-方法以將至少—_其傳遞由 構的議败分析配置咖,整合在售編、結 以提高該治療表面、結構或設備的效率。 ' 本發㈣提出—方触將至少其傳遞由對-個目標_結 '·構的SNR/power分析配置的波形,整合在至少-個治絲面、-個治 2結構’和-個治療設備’以提高至少一個治療表面、、冶療結構、和 治療設備之效果,以防止細胞和組織的損失和惡化。 本發明另提$ -㈣⑽至少—_其傳遞_卜彳目目 構的SNR/P〇wer分析配置的波形,整合在至少一個治療表面、一個治 療結構’和-個、冶療設備,以提高至少一個治絲面、治療結構、和 冶療设備之效果,以增添細胞和組織活性。 本U另提出-方法以將至少—線圈其傳遞崎—細標路徑結 • 構的SNR/Powei'分析配置的波形,整合在至少-個治療表面、一個治 . 療結構’和一個治療設備,以提高至少一個治療表面、治療結構、和 治療設備之效果,以增加細胞量。 本4明另提出-方法以將至少一線圈其傳遞由對一個目標雜結 構的SNR/P〇wer分析配置的波形,整合在至少一伽台絲面、一個治 療結構,和-個、治療設備’以提高至少一個治療表面、治療結構、和 15 200824744 TPPO/PUS213-001 治療設備之效果,以防止神經元惡化。 本發明另提出-方法靖至少—'_其傳遞姆一個目 標路徑結 構的s_ower分析配置的波形,整合在至少一個治絲面、一個治 療結構’和-個治療設備,以提高至少—個治療表面、治療結構、和 治療設備之效果,以增加神經元數量。 本發明另触-方法靖至少—_其傳遞續—個目標路徑結 •構的SNR/Power分析配置的波形,整合在至少一個治絲面、一個治 治療設備之效果,以防止在-侧I表面區域腎上腺素的神經元的惡化。 本發明另提出-方法⑽至少—線傳遞由對一個目標路經結 構的SNR/P〇wer分析配置的波形’整合在至少一個治療表面、一個治 療結構’和一個治療設備,以提高至少一個治絲面、治療結構、和 治療设備之效果’以增加在-個腦表面區域腎上腺素的神經元數量。 本發明之其齡體和優‘蹄呈現細下關要®示說明、,發明 *内容、發明專利細如附。 ‘ 【實施方式】 感應的時變電流從PEMF或PRF設備流動至一個目標路徑結構璧 如分子、細胞、組織、和器官,並且這是刺激細胞和組織可能產生有 意義的生理地反應之電流。目標路徑結構電性質感應電流的等級和分 佈。分子、細胞、組織、和器官是全部在一條感應電流路徑上譬如細 16 200824744 TPPO/PUS213-001 胞在-_接面接_。離子或配位子交互侧麵表_大分子的 鍵結位置是··触,是電化學的,可能產生—個·電磁場 (nE" )〇感應電流通過一個周圍的離子媒介到達這些區域。細胞出現 在-條電流路經導致感應電流(” j”)更加迅速地隨時間衰減 (J(t) ) 結概電谷和時間常_鍵結和其他電驗感性的膜 過程譬如膜運輪,而使細胞增加的電子阻抗。 效電子·_其錄擔錢賴和具騎的介面組態已被 .#導出。例如,在鈣離子(”咖)鍵結,由於感應Ε而結合在鍵結區的 Ca2+的濃度變化可期阻抗表_鱗領域表示為: z»Rion+~^~ 、其具有-串連電阻電容之電子等效電路的形式。其中①是角鮮 被定義作為2对、f是頻率,i =_n Zb(〇))是鍵結阻抗,並她 和“是離子鍵結路的等效鍵結電阻和電容。等效繼時間常數值 Γί〇η=ΚΐΧαΐ與離子鍵結率常數,岭關,經r,H1/kb。因而 這條路徑的—時財數由軒鍵輪力學確定。 從PEMF或PRF信號所感應之E可能導致電流流入離子鍵結路並 影響⑽離子的數量縣單位時間。其電路等價是—個橫跨等效結 合餘^_壓變化,其為—個儲存在C⑽的電荷改變的直接測量。 電何直接正比於_離子在鍵結區域的表面濃度,其電荷存貯與離 子或其它被充電蹄__麵秘面鱗。電子阻抗測量以 17 200824744 TPPO/PUS213-001 及對鍵結率常_錢動力學分析,為_錄必要的ρΜρ 波形的 配置提供值,以匹配目標路徑結構的帶通。此允許了頻率的一個必需 的範圍’對任-指定的感應E波形,以理想的耦合於目標阻抗,譬如 帶通。 與控制分子的離子鍵結是-個頻繁ΕΜρ目標,例如况+鍵結調約 素(CaM )。這k路径的用途是基於力σ速組織修理,例如骨頭修理, ' X傷的修理,毛髮修復,或其他分子、細胞、組織、和器官涉及生長 屬目子釋出的調控在各種階段的修復。生長因子如血小板衍生的生長因 子(’’PDGF’’),纖維細胞生長因子("FGF"),和表皮生長因子("^。全 部涉及在一個適當的癒合階段。血管新生和新生血管作用也是組織成 長和修理的一部分,且可由PMF調整。所有這些因素都是Ca/CaM依賴 性的。運用Ca/CaM路徑一波形可被配置,感應功率足夠地是大於背 景熱虿雜訊功率。在正確生理情況下,這波形可有一具生理地重要性 的生物效應。 ⑩ Power SNR模型對Ca/CaM的應用,需要Ca2+在CaM的鍵結動力 學的電子等價知識。在第一等級鍵結動力學中,結位置 的濃度隨時間的變化,可能經由一個等價鍵結時間常數描述在頻率領 域’ ΙΈ RionCion ,其中L和Cion是離子鍵結路的等價鍵結電阻和電 容。rioa與離子鍵結率常數,kb有關,由riaF Ri〇nCi〇n = 1;/ kb•發表的 kb值可接著用在細胞陣列模型以評估SNR,經由比較PRF信號感應電 壓與在CaM鍵結位置之熱量電壓波動。使用數值表示層反應,學如 18 200824744 TPPO/PUS213-001 V^B.SxlO'sec1, [Ca2+]=2.5UM, ^ΟμΜ, [〇^Μ]=Κ,([〇β2+]+[〇βΜ]), 產生Μ65 sec] = l. 5 msec)·。此“值可被用在一電子等效 電路針對離子鍵結’當Power SNR分析可執行任一個波形結構時。 根據本發明的實施例,一個數學模型可被描述以理解熱量雜訊是 存在於所有賴依賴雜,且絲—個最顿陳鍵立適當的 SNR。熱量雜訊的功率波譜密度,Sn((〇),可表示為: 么其中ΖΜ(Χ,ω)是目標路徑結構的電子阻抗,χ是目標路徑結構的 維度,Re表示目標路徑結構的阻抗實部。ΖΜ(χ,ω)可表為:A 200 microsecond symmetric or asymmetrical pulse repeats within approximately 〇1. The canine hair packet is a modulated l/f function and is used between 1000 Hz. Specifically, 'Lai Bo _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Use a single amplitude/power comparison with the age of a path structure to reduce the micro-shape. The bursting of the frequency of the Qiu, rectangular, and mixed waveforms of the arbitrary waveforms is shown to be about 1 to about 100,000 bursts per second, and from about 0.01 to about 1000. The burst/mother dog's fascination L signal amplitude is in a target path structure (eg tissue) in the range of about wcm to moo mV/cm. Each side burst burst may be an arbitrary function that provides a way to make the healing tissue a variety of different electromagnetic touches. The preferred embodiment of the present invention includes a pulse burst of about Π to about (10) milliseconds including a random repetition rate of about i to about 100 kHz at a burst of about 〇 1 and about a fixed repetition rate. It is used between about i. Hertz and about 1 Hz. An induced electric field is generated from about 001 001 mV/απ to about (10) mV/cm. One of the examples proposed in this case contains - about 〇. G1 milliseconds to about 1G milliseconds of high drunkenness bursts (such as 27.12 MHz) 'heavy_about i to about just bursts per second. Produces an induced electric field about . OOi mV/cm to about mV/cm. The waveform may be transmitted by the inductive or capacitive coupling. The invention further proposes a living cell and a group-electromagnetic treatment method comprising a 200824744 t-frequency 'high spectral density electromagnetic field. 3 00 Electromagnetic treatment of living cells and tissues, and includes a + = a fine concealed flap, _ Wei Jing no cell or ^ A dare to correlate with EMF-sensitive path coupling. = Configure a pass-to-noise noise ratio c, snr ") Analytical mathematical simulation of the wave-on-wave spectrum" to configure a waveform that ideally regulates blood The output of the new and new blood vessels is provided by a waveform configuration device (such as a miniaturized electronic circuit), and the output δ is prepared (for example, an ultra-lightweight coil) to face the configuration waveform. One (4) proposes a lightweight elastic coil, However, it is integrated into at least the following / accessories, accessories, foot wear, end belts, anatomical support, anatomical package purple, = sitting, mattress, mattress, wheelchair, wire, treatment chair, treatment and health Maintenance 2. If the real worker assists the wound surface equipment, the mechanical and Wei electronic stimulation reading and the East Spear 匕糸 'to deliver the ideal of the above-mentioned optimal non-invasive electromagnetic pulse treatment, to strengthen in animals, people And the repair and growth of living tissue in plants. The invention further proposes - the method of transmitting a waveform configured by a snr/p. analysis of the target path structure in a programmable manner, for example according to a time-dose program, a series of pulses or other Random or designed sequence. The present invention further provides a method for generating a signal from a waveform that is configured by the target = configuration, to be stalkable, such as according to time - μ A series of pulses, or other sequences that are designed or designed. X month is also proposed - method to provide multiple coils, transmitting waveforms configured by the target path structure of 12 200824744 TPPO/PUS213-001 SNR/Power analysis to increase the therapeutic coverage area The invention further proposes a method for providing multiple coils which are driven simultaneously or continuously (for example, multiplex communication), with the same or different above-mentioned optimal groups. The present invention is more difficult to touch and lighter. Wei system, Wei brewing by incorporating the line-focus EMF signal into the affected tissue, passes the waveform configured by the SNR/P〇wer analysis of the target path structure into the ergonomic support garment. 'This is more proposed - method to The scale line creates a daily reliance, and integrates a coiled • Active Sportswear' to transmit the waveform configured by the SNR/Power analysis of the target path structure, placed in close proximity to an anatomical target. The invention further proposes that the method transmits the beach signal to the affected tissue by means of a lightweight elastic coil or wire, and combines the coil or the wire as a whole part of the various shapes/knifes to prepare for compression, elasticity, cold compression and heat. The compression and delivery are waveforms configured by SNR/Power analysis of the target heterostructure. Turtle The present invention further proposes a method to increase the trace coverage area by using a plurality of coils, configured by a SNR/P0wer analysis of the target path structure. " The invention further proposes a method for making a coil, using a wire, to deliver a waveform configured by an SNR/P〇wer analysis of a target path structure. ^Inventively proposed - method to make a coil, using a thin elastic wire, to transmit a waveform configured by an SNR/Power analysis of a viewing path structure. This method is also proposed to provide the same or different waveforms of the target path structure by the same or different waveforms, simultaneously or continuously supplying single or multiple coils. 13 200824744 TPPO/PUS213-001 Injury treatment - and Was used to make the Θ Θ 与 与 与 标准 标准 WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU WU Configured waveforms that are integrated into the treatment couch, treatment chair, and wheelchair. The method provides a waveform of the s_〇wer miscellaneous configuration of the coil that transmits the surface path of the smear, which is integrated on various therapeutic surfaces, such as pressure relief, verifiable, flow, rotation, and air flow. surface. This month, another method is proposed to provide a coil that transmits a waveform configured by SNR/Power analysis of the target path structure, which is integrated into a therapeutic sitting such as an expandable, fluidized, foam cushion. The present invention further proposes a method for providing, _ which transmits a waveform configured by a target path __S^P〇Wer, which is integrated in at least one of: - treating a mattress cover, sheets, blankets, pillows, Pillow boxes, treatments that may impose a smooth or intermittent pressure, such as air-clearing vests. The handle further proposes a method such that the flux path can be included in any of the treatment surfaces, the structure 'or device' by transmitting a wave 14 200824744 / TPP_S213 profile configured for the SNR/p〇wer analysis of the target path structure to enhance the treatment The effect of surface, structure or preparation. The present invention further provides a method for incorporating a coil of a waveform configured by SNR/Power analysis of a target path structure into a footwear such as a shoe. The present invention further proposes a method for integrating at least the arbitrarily configured analysis coffee to integrate the sales and processing to improve the efficiency of the therapeutic surface, structure or device. 'This issue (4) proposes that the square touch will at least pass the waveform configured by the SNR/power analysis of the pair-target _ junction's structure, integrated in at least one of the ruled surface, the -2 rule 2 structure, and a treatment The device 'to enhance the effects of at least one therapeutic surface, therapeutic structure, and therapeutic device to prevent loss and deterioration of cells and tissues. The present invention further provides that the waveform of the SNR/P〇wer analysis configuration of at least one of the at least one treatment surface is integrated into at least one treatment surface, a treatment structure, and a treatment device to improve At least one effect of the silk surface, therapeutic structure, and treatment equipment to increase cell and tissue activity. The present invention further proposes a method for integrating at least the waveform of the SNR/Powei' analysis configuration of the coil-synchronized path structure into at least one treatment surface, a treatment structure, and a treatment device. To increase the effect of at least one therapeutic surface, therapeutic structure, and therapeutic device to increase the amount of cells. The invention further proposes a method for transmitting at least one coil by a waveform configured for SNR/P〇wer analysis of a target heterostructure, integrated in at least one gamma surface, a treatment structure, and a treatment device 'To enhance the effects of at least one therapeutic surface, therapeutic structure, and treatment equipment for 200824744 TPPO/PUS213-001 to prevent neuronal deterioration. The invention further proposes that the method at least ___ transmits a waveform of the s_ower analysis configuration of a target path structure, integrated in at least one of the ruled surface, a therapeutic structure, and a treatment device to enhance at least one therapeutic surface The effects of treatment structures, and therapeutic devices to increase the number of neurons. The other touch-method of the present invention at least _ transmits the waveform of the SNR/Power analysis configuration of the target path junction, and integrates the effect on at least one of the treatment surfaces and the treatment device to prevent the on-side I Deterioration of neurons in the surface region of adrenaline. The invention further proposes - method (10) at least - line transfer of a waveform configured by SNR/P〇wer analysis of a target path structure 'integrated on at least one treatment surface, one treatment structure' and one treatment device to enhance at least one treatment The effect of silk surface, therapeutic structure, and therapeutic equipment 'to increase the number of neurons in the brain surface area of adrenaline. The invention of the invention and the invention of the invention are as follows. ‘Embodiment】 The induced time-varying current flows from the PEMF or PRF device to a target path structure such as molecules, cells, tissues, and organs, and this is a current that stimulates cells and tissues to produce meaningful physiological responses. The target path structure electrical properties induce the level and distribution of current. Molecules, cells, tissues, and organs are all in an inductive current path, such as thin 16 200824744 TPPO/PUS213-001 Cells are connected at -_ junction. Ion or ligand interaction side table _ macromolecular bond position is · · touch, is electrochemical, may produce - an electromagnetic field (nE ") 〇 induced current through a surrounding ion medium to reach these areas. Cells appear in the - current path leading to induced current ("j") decaying more rapidly over time (J(t)). The electrical and valley-time junctions and other electro-sensitive membrane processes such as membrane transporters And increase the electronic impedance of the cells. Effective electronic · _ its record of money and Lai interface configuration has been . #export. For example, in the calcium ion ("coffee" bond, the concentration change of Ca2+ combined in the bonding region due to the induction of enthalpy can be expressed as an impedance table. The scale field is expressed as: z»Rion+~^~, which has a series resistance capacitor The form of the electronic equivalent circuit. 1 is the angle is defined as 2 pairs, f is the frequency, i = _n Zb (〇) is the bond impedance, and she and "is the equivalent bond of the ion bond junction Resistance and capacitance. Equivalent relay time constant value Γί〇η=ΚΐΧαΐ and ion bond rate constant, Lingguan, by r, H1/kb. Therefore, the time-time of this path is determined by the Xuanjian wheel mechanics. The E induced from the PEMF or PRF signal may cause current to flow into the ionic bond junction and affect the number of (10) ions per unit time. Its circuit equivalence is a direct measurement across the equivalent junction residual voltage, which is a direct measurement of the charge change stored at C(10). The electricity is directly proportional to the surface concentration of the _ ion in the bonding region, and its charge is stored with ions or other hoofs. The electronic impedance measurement provides a value for the configuration of the necessary ρΜρ waveform to match the bandpass of the target path structure with 17 200824744 TPPO/PUS213-001 and for the bond rate constant _ kinetic analysis. This allows a necessary range of frequencies 'to-to-specified inductive E waveforms to ideally couple to the target impedance, such as bandpass. The ionic bond with the control molecule is a frequent ΕΜ target, such as the condition + bond modulating (CaM). The purpose of this k-path is based on force sigma tissue repair, such as bone repair, 'X-injury repair, hair repair, or other molecules, cells, tissues, and organs involved in the growth of the genus. . Growth factors such as platelet-derived growth factor (''PDGF''), fibroblast growth factor ("FGF"), and epidermal growth factor ("^ are all involved in an appropriate healing phase. Angiogenesis and neovascularization The role is also part of the organization's growth and repair, and can be adjusted by the PMF. All of these factors are Ca/CaM dependent. A waveform can be configured using the Ca/CaM path, and the inductive power is sufficiently greater than the background thermal noise power. In the correct physiological situation, this waveform can have a physiologically important biological effect. 10 Power SNR model for Ca/CaM application requires electronic equivalence knowledge of Ca2+ bonding dynamics in CaM. In junction kinetics, the concentration of the junction position over time may be described in the frequency domain via an equivalent bond time constant ' ΙΈ RionCion , where L and Cion are the equivalent bond resistances and capacitances of the ionic bond junction. Associated with the ionic bond rate constant, kb, by riaF Ri〇nCi〇n = 1; / kb • published kb values can then be used in cell array models to assess SNR, by comparing PRF The signal induced voltage fluctuates with the thermal voltage at the CaM bonding position. The value is used to represent the layer reaction, such as 18 200824744 TPPO/PUS213-001 V^B.SxlO'sec1, [Ca2+]=2.5UM, ^ΟμΜ, [〇^ Μ]=Κ,([〇β2+]+[〇βΜ]), yield Μ65 sec] = l. 5 msec)·. This "value can be used in an electronic equivalent circuit for ionic bonding" when Power SNR analysis can perform any of the waveform structures. According to an embodiment of the invention, a mathematical model can be described to understand that thermal noise is present in All of the dependencies are mixed, and the silk is the best SNR. The power spectral density of the thermal noise, Sn((〇), can be expressed as: where ΖΜ(Χ,ω) is the electronic impedance of the target path structure, χ is the dimension of the target path structure, and Re represents the real part of the impedance of the target path structure. ΖΜ(χ,ω) can be expressed as:

Zui^co)Zui^co)

Re+Ri + Re r tanh(^c) 這個等式清楚_示目標路徑結構的轩峨,和細胞歧體電 妃),細胞内流體的電阻("Ri")和細胞膜間電阻⑽”),其被電路 上^^接到目標路徑結構,都造賴雜訊的過遽。 ⑽―對SNR評估的一種典型的方法使用方均跟_雜訊輕的一 =值。其計算方法為取一整數以參術啦相的平方根在與完 :、回應或目標路徑結構的頻寬相_所有頻率售可由一 達:Re+Ri + Re r tanh(^c) This equation is clear _ indicates the target path structure of Xuanyuan, and cell dislocation electric 妃), the resistance of the intracellular fluid ("Ri") and cell membrane resistance (10)") It is connected to the target path structure by the circuit ^^, which is caused by the noise. (10) ― A typical method for SNR evaluation uses the _ noise light one = value. The calculation method is An integer is the sum of the square root of the phase and the end of the response, or the frequency of the target path structure.

RMS 其中,IW i是霞械駭目標雜讀有鮮 19 200824744 TPPO/PUS213-001 之最大電壓振幅。 本發明之一實施例包含有高波譜密度的脈衝突發封包,因此療法 在相關的電介質路(如細胞膜受體,離子對細胞的酵素的鍵結和—般 穿膜電位變動)的效果增強了。並且,由增加被傳達制目_細^ 境的鮮組成要件雜量,大範_生鱗_象(修調整的生長 因子和細胞激素分泌和調控分子的離子鍵結)可適用於已知的組織成 長機制,是可以達成的。 ' 鲁本個之—實施舰用—俯賴,它高_贿封包,應用 於輯突發封包單極缝謂或正鎌衝其献高峰電場納 108至約刚v/cm,可適用對軟和堅硬組織產生對生物恢復過程更佳 的效果。 A 由應用„個高波譜密度電壓封包作為 ,或雜突較翻錢繼練調____ :量能顯著比未調變的含有在她鮮範圍脈衝的脈衝突: =由ΓΓ峨大量減少,在重覆突發長列則 =拿的、和較趙機的振幅於其爾—致的脈衝突發封包。相對 _可因=_關的電介趣和減少功率需要量,此雙重 以傳避2=1綱—f雜,峨賴,本細 子==標路徑結構’譬如人和動物的離子和配位 ,乍細和預防疾病的的用途。一個數學模型其有至少一個波形 20 200824744 TPPO/PUS213-001 參量被用來配置至少一波形以被目標路徑結構譬如離子和配位子所麵 合(步驟101)。配置的波形滿足P〇wer SNR模型以致於對一個指定 和已知的目標路徑結構可以選擇至少一個波形參量以致於波形於其背 景活性(譬如電壓之底線熱量波動,與取決於細胞和組織狀態的目標 路徑結構上之電子阻抗,該狀態至少是休息,生長,替換,和傷害反 應的其中之一)之上是可被偵測的(步驟1〇2)。RMS where IW i is the maximum voltage amplitude of the TPPO/PUS213-001. One embodiment of the present invention includes a burst of high spectral density bursts, whereby the effect of the therapy on the associated dielectric pathway (e.g., cell membrane receptors, ion-to-cell enzyme bonding, and general transmembrane potential changes) is enhanced. . Moreover, by increasing the amount of fresh components that are conveyed to the _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The organization growth mechanism can be achieved. 'Luben's - implementation of the ship - depreciation, it is high _ bribe package, applied to the series of sudden packet unipolar seam or positive rushing its peak electric field nano 108 to about just v / cm, applicable to soft And hard tissue produces better results for the biological recovery process. A is applied by the application of a high-wave spectral density voltage packet, or the spurt is more than the tumbling of the money. The amount of energy can be significantly greater than that of the unmodulated pulse that contains the pulse in her fresh range: = a large reduction due to ΓΓ峨Repeated burst long column = take, and the amplitude of the Zhao machine is in the burst of the pulse burst. Relative _ can be = _ off the electrical interest and reduce the power demand, this double to avoid 2 = 1 class - f miscellaneous, blame, this subs = = = standard path structure 'such as human and animal ion and coordination, fine and prevent disease use. A mathematical model with at least one waveform 20 200824744 TPPO The /PUS213-001 parameter is used to configure at least one waveform to be covered by a target path structure such as an ion and a ligand (step 101). The configured waveform satisfies the P〇wer SNR model for a specified and known target The path structure may select at least one waveform parameter such that the waveform is active in its background (eg, the bottom line of the voltage, the thermal fluctuation, and the electronic impedance of the target path structure depending on the state of the cell and the tissue, the state being at least rest, growth, replacement, and hurt Above one of the responses is detectable (steps 1〇2).

本案用以產生電磁信號之一較佳實施例,其包括任意波形突發, 該突發有至少一個波形參量其包括多數頻率組成其範圍從約〇.〇1赫 茲至約100兆赫,其中多數頻率組成滿足p〇wer SNR模型(步驟 102)。可以電感麟或電容的方式產生—紐電磁式信號,如前述,A preferred embodiment of the present invention for generating an electromagnetic signal comprising an arbitrary waveform burst having at least one waveform parameter comprising a plurality of frequencies comprising a range from about 〇.〇1 Hz to about 100 MHz, wherein the plurality of frequencies The composition satisfies the p〇wer SNR model (step 102). Can be generated by means of inductors or capacitors - New Zealand electromagnetic signals, as mentioned above,

以配置至少-波形(步驟⑽)。電磁式信號被與一個目標路徑結構 (譬如離子和配位子)輕合’經由一個搞合設備(譬如電極或感應器) 的輸出’放置在與目標路徑結構接近的位置(步驟1〇4),使用一個定 位叹備,經由將耦合設備與定位設備耦合之方式(步驟卿。搞合會 增_子和_子對靖分_、細胞、和_結合的雛。麵 吩卜嫩、創傷包紮 所古Γ、床墊塾、鞋子、輪椅、椅子、和可並置於活組織和細胞的 =謂和結構。整合_與定位設備的好處是,治療可執 订在0该巾柯齡意较齡在任何地方和時間。 200824744 TPPO/PUS213-001 導線)結合’而控制電路也可無線式運作。至少一個連接器的相反的 末端與一產生設備如電線圈203結合。微型控制電路201用一個應用 形成波形的數學模型之方法製作。所配置的波形必須滿足p〇wer 模型,以便對一個指定和已知的目標路徑結構而言,可以選擇滿足 Power SNR的波形參量因而使波形在目標路徑結構其背景活性之上可 被偵測。本案一較佳實施例應用一數學模型以在一目標路徑結構(如 離子和配位子)中感應一時變磁場和時變電場,包含約〇1至約1〇〇 毫秒突發,其具有約1至約謂微秒,重覆約0·1至約1〇〇脈衝/每 秒的長方形脈衝。誘發電場的電場高峰振幅在約1 uV/cm和約⑽ mV/cm之間’隨著一個修正過的1/f函數而變化,其中f =頻率。本 案之-較佳實施例中,配置的波形可能應用在一個如離子和配位子的 目標路徑結構,持續-較佳的總曝光時間,每天1分鐘到24〇分鐘。 然也可使用其它曝光時間。由微型控制電路2Q1配置的波形,通過連 接器202,直接連接-個產生設備2〇3如電線圈。產生設備2〇3傳遞 一個脈衝的磁場,其配置依據可絲對一個目標触結構譬如皮膚組 織提供治療的-條學翻。微魏機路翻—臟爾在一定時 間中’亚且在-固定的時間中可自動重複地應用一脈衝磁場至所有所 需的用途,例如10次/每天。 微型控制穆淑可編姉球讀時__應用脈 衝磁場。核-雛實補可經續—個紐雜整合峨用在毛髮 綱治療,因而該元件具有獨立性。結合一個脈衝磁場與一個目· 22 200824744 TPPO/PUS213-001 徑結構如離子和配位子,在治療和預防上可減少炎症因此減少痛苦並 在治療區域促越合。當電線圈用作產生設備2〇3,電子線圈可由根 據法拉第定律在目標路徑結構誘發時變電場的一時變磁場供給動力。 一個由產生設備腦所產出的電磁式信號也可使用雜轉結, 其中電極是錢接觸於皮膚或目標路錄構的其餅部的導電性界 限。在本案另—實施例中,由產生設備2〇3所產出的電磁式信號也可 使用靜4結’其中空氣間隙存在於一個產生設傷哪(如一電極) 個優點是細__σ小龜的電财以翻在—般的物理療法 療ν式I可依而要姻在組織成長、鎮痛、和組織與器官癒合的任 一個位置。應用此本案較佳實施例的一有利結果是,組織成長、修理、 、隹濩可在任何地方和任何時候完成或加強。應用此本案較佳實施例的 1果疋成長、修理’與分子、細胞、組織、和器官的維護 可在任何地方和任何喃完成或加強。 圖3柄述本案較佳實施例之一微型控制電路_之結構圖。微型 =17 波形,其麟—產蝴如® 2 "〇 , 例具路300有一個電源譬如鐘電池301。電源的較佳實施 源i y 一7電壓,但也可使用其它電壓。在本案另一實施例中,電 、W疋固外部電力來源譬如一個電流出口如AC/DC出口,經由例 如插座和導線遍卷此& ^ 、、工田例 、1發明結合。一可調變電源供應器3〇2控制對微型 23 200824744 ' _ TPPO/PUS213-001 100pL個部份進入ι· 5ml Eppendorf試管。所有Eppendorf試管包含 反應混合物其保持在〇飞,然後轉移到特別設計經由Fisher Scientific型號900熱轉換器所預熱的水之恆定灌注而維持在37 ± 0· 1C的水浴。溫度用一根熱敏電阻探針如型號811〇一2〇 監測,在所有貫驗期間浸在一支Eppend〇rf試管裡。反應由2· 5|J[ 32P ATP起使’並由包含30 · Μ _之Laemmli樣品緩衝溶液終止。五 • 個空白樣品的極小值在各個實驗中被計數。空白溶液包括了一個總化 ‘❿ 驗混合物減去下列其中之一,活化部分Ca2+、CaM、MLC或MLCK。排除 空白計數比300 cpm計數高的實驗。石粦酸化作用可以進行5分鐘並由 整合於MLC的計數32PM,使用tm Analysis型號5303 Mark V液體閃 式計數器所評估。 信號包括了具重複的高頻率波形的突發。在所有曝光中,振幅被 維持固定在G.2G且重複率是丨burSt/see。突發_在65jusec到 lOOOusec間,根據p0WerSNR分析的投射而變化,其顯示了在突發期 ⑩間接近5_sec時,達到最佳化的Power SNR分析。結果顯示在圖7, • 其中突發寬度701以nsec為單位為X軸而肌凝蛋白磷酸化作用作 • 為treated/sham為Y軸。可以發現,PMF在Ca2+與CaM的結合的效果 達到最大值將近50〇nsec,就如同power SNR模型的說明。 這些結果證實,根據本案一較佳實施例配置的PMp信號,將在給 定的磁場振幅下,足夠達成最佳化p〇werSNR的突發期間中,極大地增 加肌凝蛋白磷酸化作用。 26 200824744 TPPO/PUS213-001 範例2 本案一較佳實施例中,power SNR模型的用途進一步證實在活體 内創傷修理模型。鼠創傷模型在生物力學和生物化學上已被良好描 述,並且被使用在這項研究中。本研究採用健康、年輕成年雄性、超 過 300 克的 Sprague Dawley。 • 動物以腹膜内樂量 Ketamine 75 mg/kg 和 Medetomidine 0.5 -· mg/kg麻醉。在充分麻醉後,背部除毛,準備一種稀釋優硤/酒精溶 液’並使用消毋技術覆蓋。使用削解剖刀,gcm線性切開皮膚至各 隻鼠背的繃帶。創傷邊緣使任何殘餘的皮膚纖維被直接破壞,留下約 4 cm直徑的開放創傷。經由施加壓力以避免對皮膚邊緣的任何損傷達 到止血效果。皮膚邊緣然後以4-〇 Ethil〇n連續縫合。手術後,對動 物麵内施加丁基原啡因〇·卜〇· 5mg/kg。他們被安置在獨立的籠子, 隨意地接受食物和水。 • PMF曝光包括二個脈衝射頻波形。第-個是-個鮮臨床PRF信 • 號,包含65障突發,其具有27.12兆赫正弦波,i高斯振幅結 覆600 bursts/sec。第二個是根據本案一較佳實施例重組的卿信 號。此鋪突發躺增加至2_sec且振幅和重複率分別減少了到 〇. 2G和5 bursts/sec。使用PRF每日兩次每次3〇分鐘。 抗拉強絲触_赚之後。_寬—的賴小條是由對每 個樣本的傷痕之垂線橫切而來,並用來測量抗拉強度,以峰/咖2為單 27 200824744 TPPO/PUS213-00 位。小條從各隻鼠的同樣區域切除,以保證測量的—貫性。小條然後 放上張力計。小條貞荷1Gram/min並記錄麵翻_被之前產生的 $大Power。最後比較的抗拉賊為取在相同傷口的兩小條之最大負 荷的平均值,以kg/mm2為單位。 實驗絲顯示,對65卿1 G義PRF信號而言,平均抗拉強 又對於只驗,,且疋19. 3 ± 4· 3 kg/mm2,對照組是13· 〇 ± 3.5政/刪2 (Ρ<· 01),其有觸增量。相對地,對於由依據本案之—較佳實施例 使·從SNR模型配置的_赋〇· 2 Gauss PRF信號,平均抗 拉強度對於實驗組是21.2 ± 5.6 kg/醜2,對照組是i3. ? ± 4.丨_ (ρ<· 01)其有540冒!。這二個信號的結果並非顯著不同。 這些結箱和’杨之—触魏射魏置日聰使職低功 率而產生的-鑛信號。依據本案之一較佳實施例配置的爾信 旒’在昧▲型中以低功率方式之加速的創傷修理,相對於一個臨床卿 g要超過二個數量級的更多功率。 範例3 神經二的PRF電磁場通過powerSNR方法在培養物的 立、言個區麻#要土。養物由胚胎期15'16天之喷齒目動物中腦所建 、/ 由機械研碎蝴、分解成為單細胞,且細胞被置在被定 我的媒介或具血清的媒介。細胞在6天培養以 經元已成熟已發展出使他們一 ^ 28 200824744 TPPO/PUS213-001 以後,收集調整的媒介。酵素連接的免疫吸附分析法("ELISAs”)對於 生長因子如成纖維細胞生長因子beta (" FGFb,r)是使用於定量其釋放 至媒介的量。多巴胺神經元可用對盼基[氨酸經化酵素CTH”)的抗體 辨ΰ忍’轉換氨基酸酚基乙氨酸成L—d〇pa的一酵素,多巴胺前體,由於 多巴胺神經元是在此系、统中生產此酵素唯一的細胞。細胞的定量由計 數TH+細胞在垂直小條橫跨培養瓜、1〇〇χ放大率之下計數。To configure at least the waveform (step (10)). The electromagnetic signal is lightly coupled to a target path structure (such as ions and ligands) and placed at a position close to the target path structure via an output device (such as an electrode or sensor) (steps 1〇4) , using a positioning sigh, by coupling the coupling device with the positioning device (steps. The combination will increase the _ sub and _ sub-combination _, cells, and _ combination of the young. Faced tender, wound dressing The ancient Γ, mattress 塾, shoes, wheelchair, chair, and can be placed in the living tissue and cells = the structure and structure. Integration _ and positioning equipment has the advantage that the treatment can be ordered at 0. In any place and time. 200824744 TPPO/PUS213-001 wire) combined with 'control circuit can also operate wirelessly. The opposite ends of at least one of the connectors are combined with a generating device such as an electrical coil 203. The micro control circuit 201 is fabricated by a method of applying a mathematical model for forming a waveform. The configured waveform must satisfy the p〇wer model so that for a given and known target path structure, the waveform parameters that satisfy the Power SNR can be selected so that the waveform can be detected above the background activity of the target path structure. A preferred embodiment of the present invention applies a mathematical model to induce a time-varying magnetic field and a time-varying electric field in a target path structure (such as ions and ligands), comprising a burst of about 1 to about 1 millisecond, which has Approximately 1 to about microseconds, repeating a rectangular pulse of about 0.1 to about 1 pulse per second. The electric field peak amplitude of the induced electric field is between about 1 uV/cm and about (10) mV/cm' as a function of a modified 1/f function, where f = frequency. In the preferred embodiment of the present invention, the configured waveform may be applied to a target path structure such as ions and ligands, for a continuous-better total exposure time of from 1 minute to 24 minutes per day. Other exposure times can also be used. The waveforms configured by the micro control circuit 2Q1 are directly connected to a generating device 2〇3 such as an electric coil through the connector 202. The generating device 2〇3 delivers a pulsed magnetic field that is configured to provide treatment for a target contact structure, such as a skin tissue. The micro-wei machine turns over-dirty in a time interval and can automatically apply a pulsed magnetic field to all required uses, for example, 10 times per day. Micro-control Mu Shu can edit the ball when reading __ application pulse impulse magnetic field. The nuclear-fighting supplement can be continued—a neo-integration is used in the treatment of the hair, so the component is independent. Combining a pulsed magnetic field with a 22 222424 TPPO/PUS213-001 diameter structure such as ions and ligands reduces inflammation in treatment and prevention, thus reducing pain and promoting healing in the treatment area. When the electric coil is used as the generating device 2〇3, the electronic coil can be powered by a time-varying magnetic field that induces a time-varying electric field in the target path structure according to Faraday's law. An electromagnetic signal produced by the brain of the generating device can also use a heterojunction, where the electrode is the conductive boundary of the cake portion of the skin that is in contact with the skin or target path. In another embodiment of the present invention, the electromagnetic signal generated by the generating device 2〇3 can also use the static 4 junction 'where the air gap exists in one of the generating injuries (such as an electrode). The advantage is that the fine __σ small turtle The electricity can be used in any kind of physical growth, analgesia, and tissue and organ healing. An advantageous result of applying the preferred embodiment of the present invention is that tissue growth, repair, and maintenance can be accomplished or enhanced anywhere and at any time. The maintenance of the growth, repair, and maintenance of molecules, cells, tissues, and organs using the preferred embodiment of the present invention can be accomplished or enhanced anywhere and at any time. FIG. 3 is a structural diagram of a micro control circuit of a preferred embodiment of the present invention. Miniature = 17 waveform, its lining - production butterfly such as ® 2 " 〇, 例路路300 has a power supply such as clock battery 301. The preferred implementation of the power supply source i y - 7 voltage, but other voltages can be used. In another embodiment of the present invention, the external source of electrical power, such as a current outlet, such as an AC/DC outlet, is circulated through, for example, a socket and a wire, and the combination of the invention and the invention. A variable power supply 3〇2 controls the micro 23 200824744 ' _ TPPO/PUS213-001 100pL parts into the ι · 5ml Eppendorf test tube. All Eppendorf tubes contained the reaction mixture which was kept in a helium fly and then transferred to a water bath that was specifically designed to maintain a 37 ± 0. 1 C constant perfusion of water preheated via a Fisher Scientific Model 900 heat exchanger. The temperature is monitored with a thermistor probe such as Model 811〇2〇 and immersed in an Eppend〇rf tube during all runs. The reaction was initiated by 2·5|J [32P ATP] and terminated by a Laemmli sample buffer solution containing 30 · Μ _. The minimum values of five blank samples were counted in each experiment. The blank solution includes a generalized ‘test mixture minus one of the following, activating part of Ca2+, CaM, MLC or MLCK. Experiments with blank counts higher than 300 cpm were excluded. The acidification of the sarcophagus can be carried out for 5 minutes and is evaluated by a count of 32 PM integrated into the MLC using a tm Analysis model 5303 Mark V liquid flash counter. The signal includes bursts with repeated high frequency waveforms. In all exposures, the amplitude was maintained at G.2G and the repetition rate was 丨burSt/see. Burst_ varies from 65 jusec to lOOOusec, according to the projection of the p0WerSNR analysis, which shows an optimized Power SNR analysis when the burst period is close to 5 sec. The results are shown in Figure 7, where the burst width 701 is the X-axis in nsec and the myosin phosphorylation is treated = sham is the Y-axis. It can be seen that the effect of PMF on the combination of Ca2+ and CaM reaches a maximum of nearly 50 〇 nsec, as explained by the power SNR model. These results demonstrate that the PMp signal configured in accordance with a preferred embodiment of the present invention will greatly increase myosin phosphorylation during a burst period sufficient to achieve an optimized p〇werSNR for a given magnetic field amplitude. 26 200824744 TPPO/PUS213-001 Example 2 In a preferred embodiment of the present invention, the use of the power SNR model further confirms the in-vivo wound repair model. The rat wound model has been well described in biomechanics and biochemistry and is used in this study. This study used a healthy, young adult male, Sprague Dawley over 300 grams. • Animals were anesthetized with intraperitoneal Ketamine 75 mg/kg and Medetomidine 0.5 -·mg/kg. After adequate anesthesia, remove the hair from the back, prepare a diluted sputum/alcohol solution' and cover it with sputum. Using a scalpel, gcm linearly cuts the skin to the bandage of each rat's back. The wound edge causes any residual skin fibers to be directly destroyed, leaving an open wound of approximately 4 cm in diameter. The hemostasis effect is achieved by applying pressure to avoid any damage to the edges of the skin. The edges of the skin are then sutured continuously with 4-〇 Ethil〇n. After the operation, butyl morphine and phlegm and phlegm and 5 mg/kg were applied to the animal's surface. They were placed in separate cages to receive food and water ad libitum. • PMF exposure includes two pulsed RF waveforms. The first is a fresh clinical PRF signal containing a 65-barrier burst with a 27.12 MHz sine wave and an i-Gaussian amplitude covering 600 bursts/sec. The second is a reorganization of the Qing signal according to a preferred embodiment of the present invention. This shop burst increased to 2 sec and the amplitude and repetition rate were reduced to 〇. 2G and 5 bursts/sec, respectively. Use PRF twice daily for 3 minutes each time. Tensile strong silk touch _ earned after. The _ wide- sized strip is cut from the vertical line of the flaw of each sample and used to measure the tensile strength, with peak/coffee 2 as the single 27 200824744 TPPO/PUS213-00. The strips were removed from the same area of each mouse to ensure the measurement-performity. The strip is then placed on the tension meter. The strip is loaded with 1Gram/min and the recording surface is turned over. The final comparison of the tensile thief is the average of the maximum loads of the two strips taken in the same wound, in kg/mm2. The experimental silk shows that for the 65 qing 1 G sense PRF signal, the average tensile strength is only for the test, and 疋 19. 3 ± 4 · 3 kg / mm 2 , the control group is 13 · 〇 ± 3.5 / delete 2 (Ρ<· 01), which has a touch increment. In contrast, for the _Fus 2 Gauss PRF signal configured by the SNR model according to the preferred embodiment of the present invention, the average tensile strength is 21.2 ± 5.6 kg/ugly 2 for the experimental group and i3 for the control group. ? * 4.丨_ (ρ<· 01) It has 540! . The results of these two signals are not significantly different. These knots and the 'Yangzhi'---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- According to a preferred embodiment of the present invention, the repair of the wound in the low-power mode in the 昧▲ type is more than two orders of magnitude more power than a clinical one. Example 3 The PRF electromagnetic field of the neuron is passed through the powerSNR method in the culture. The nutrients are built by the midbrain of the 15'16 day embryonic period of the embryonic period, / mechanically pulverized, decomposed into single cells, and the cells are placed in the medium or serum-containing medium. The cells were cultured in 6 days to obtain the adjusted medium after the meta-mature has been developed to make them a ^ 28 200824744 TPPO/PUS213-001. Enzyme-linked immunosorbent assays ("ELISAs) for growth factors such as fibroblast growth factor beta (" FGFb, r) are used to quantify the amount of their release to the vehicle. Dopamine neurons can be used with anti-probiotic [ammonium] The acid-chemical enzyme CTH") recognizes the enzyme that converts the amino acid tyrosine to L-d〇pa, a dopamine precursor, because dopamine neurons are the only ones that produce this enzyme in this system. cell. The quantification of cells was counted by counting TH+ cells under vertical strips across the cultured melon, 1 〇〇χ magnification.

也清包含支持神經細胞的生存的營養素和生長因子。血清的去除 會導致神經細胞的死亡。改變培養基並使細胞暴露於ρΜρ (功率等級 6,突發寬度3GG0usec,頻率〗。運用四個分組。小組】不使 用PMF曝光(空白組)。小組2使用預治療(在中度變化之前層治療 2個小時)。小組3使用後治療(在中度變化之後層治療2個小 時)。小組4使用直接治療(在中度變化同時進断爾治療)。 結果顯示,當培養物在血清除去之前暴露於p勝下時,兩天後多Also contains nutrients and growth factors that support the survival of nerve cells. Removal of serum can lead to the death of nerve cells. Change the medium and expose the cells to ρΜρ (power level 6, burst width 3GG0usec, frequency〗. Use four subgroups. Groups) do not use PMF exposure (blank group). Group 2 uses pre-treatment (pre-treatment before moderate changes) 2 hours). Group 3 was treated after use (2 hours after moderate changes). Group 4 used direct treatment (at the same time with moderate changes). The results showed that before the culture was removed from the serum When exposed to p wins, more than two days later

巴胺神經元生存的數量有概增量。其它治療療法對神經元生擁量 沒有顯著侧。結果顯示在圖6,其中治療方式顯示在X轴,神經元 的數量顯示在γ軸。 “如圖7,其巾治賴示在路,神經元的數麵示在Y轴,本B ^ 了 ’ PMF信號D和E在減少血清媒介中濃度後,化胺神經&amp; 數量分別增加了 46%權。兩侧言號被都配置以突發寬度3__ 趣率分別是5/sec和1/sec。明顯地,信號^一個持續過_ 貫驗執行,但信號Ε只執行一次:在也清除去之前2小時 29 200824744 TPPO/PUS213-001 相同(麥見上面),產生相贩果的數值〈樵與48%)。由於在媒介中血 清的減少以致營養素和生長因子可獲得性降低,歷經由培養這些因 素誘發這些因素的合成或釋出。 實驗的此部份職說軸6-〇職誘發之層毒性的作用,產生一 清楚描述的多巴胺細胞死亡機制。此分子通過高親合度多巴胺運輸子 進入細胞並禁止粒腺體的酵素複合體j,於是經由氧化應力殺死這些 神經το。培養物以25μΜ 6-0HDA,在持續性或急性pmp曝露過程後進 ^ 行處理。目8說明這些結果,其巾治療顯示在X軸,神經元的數量顯 不在γ軸。在沒有PMF治療下毒素殺死了大約8〇%的多巴胺神經元。 使用PMF之下(功率:6;突發寬度=3Q_sec;頻率=1/sec),使神 經細胞的生存量在相較於僅有6-〇HDA(2.6-fold; Ρ£〇·〇2)下大為增 加這個結果頒現出與為帕金森症發展的神經保護方法有特殊相關, 口為6 0HDA在帕金森症標準嗔齒目動物模型中被用於損害多巴胺神 、、二元且毋性機制與帕金森症本身之神經衰退的一些方面有些相似。 範例4 在這個例子中在活體内模型中使用電磁場能量刺激金管新生作 用。使用兩個不同信號,——個根據先前技術配置根據,另一個根據本 發明之-實施例配置。一百零八隻每隻重約3〇〇克的細卿e-Dawley 公i等分成九組。所有動物以ketamine/acepr〇mazine/Stad〇1混合 物〇· 1 cc/g麻醉。使用無菌外科技術,以顯微手術技術每隻動物採取 30 200824744 TPPO/PUS213-001 一 12到14cm的尾巴動脈。動脈注滿60 U/ml肝素化鹽以去除所有血 液或栓子。 這些平均直徑〇· 4毫米到0· 5毫米的尾部血管,然後縫合至橫切 的最接近末稍的右大腿骨動脈小段,使用二端到端接合法,創造一個 大腿骨動脈圈。所產生的圈然後放置在一個製作在動物的胃腸内壁/ 鼠蹊肌組織的皮下口袋,且鼠蹊切口用4-0 Ethilon缝合。然後每個 ^ 動物任意地置入九個小組之一:小組1到3 (控制組),這些鼠沒有接 _ 受電磁場治療並在4 8,12週後殺死;小組4到6,治療每日兩次, 母次30分#里’使用〇· 1高斯電磁場持續4,8,12週(動物分另帷4, 8,12週後殺死);治療每日兩次,每次3〇分鐘,使用2· 〇高斯電磁 場持續4 ’ 8 ’ 12週(動物分別在4,8,12週後殺死)。 脈衝電磁能量施加於所處理的組別,使用根據本發明之一實施例 製作的叹備。貫驗組的動物接受每日兩次的治療,每次go分鐘,〇. 1 高斯或2· 0高斯,使用短的脈衝(2毫秒到20毫秒)27· 12兆赫。動 ♦物被安置在塗抹器頂部上方並被限制,以保證能正確的施加治療。在 氣腹膜嶋打ketamine/acepromazine/Stadol並在靜脈下施打肝素 100 g 進行再麻醉。使用先前鼠鎮切口,大腿骨動脈可被明顯辨 』板一大腿/尾部動脈圈然後接近末稍地與接合區隔絕,並且將 血g夾緊之後殺死動物。此圈被注射以鹽伴隨0· 5cc到1· Occ的有 色穿:$ 口棱的導管並夾緊。小心的切下腹部上方的皮膚,於 疋動*路$來。血管触刺的定量化,是經由職由管腔内乳 31 200824744 TPPO/PUS213-001 汁描述_血管形錢蓋的表面之方法定量。之後錢SPSS統計分析 k體對於所有結果進行分析。 在血&amp;新生伽上治療彳|和未、練的老氣,其最明_區別發生 在弟4週。在該期間,在控制組中未發現新血管形成,然而,制固被 治療的小組在血管新生作用上,在G cm2對142 ± G 8Q — (p〈 01)有相似的統s十重要證據。這些區域出現在當乳汁分段地沿著 - 動脈圈的邊分佈。在8週時,控制組開始展示出血管新生作用,被測 Φ里在〇.7 土 〇·82 cm2。兩個被治療的小組在8週時再次具有幾乎相的 統計重要性(p &lt; 0.咖)的血管露出,3. 57 ± L 82 cm2對於G.〗胸沾 組別’ 3. 77 ± 1.82 cm2對於2. Ggauss組別。在12週時,控制組中 的動物展現了 1. 75±0.95αη2的血管新生作用,而〇. i §麵組展現 出 5. 95 ± 3· 25 cm2、2. 0 gauss 組別展現 6. 2〇 ± &amp; 95 —的形成 樹枝狀的血管。再次地’兩個治療組又展現可與控制組相比的具統計 意義(P &lt; 0· 001)的發現。 • 這些實驗性研究結果顯示出,根據本發明之-實施例的一個 隔絕的動脈圈的電磁場刺激,會大量增加在一個活體内鼠模型 量的血管新生作用。增加的血管新生顯示在制 療的小組中。在兩個高斯等級測試上並未發現區別,如同本發明_ 論預測。 上述之具體實施例,對-以電磁場治療人和動物細胞、組織、和 器官之整合線圈裝置以及其方法’本發日月可在不離開本發日月續神及 32 200824744 ^ TPPO/PUS213-001 &amp;本特徵各種狀之嫩。树狀軸為峨附之申請專利 範圍所限定,碰_上親輯關,财财請袖麵^相 等之變化均應包含於本發明中。 【圖式之簡單說明】 圖i為本案較佳實施例之使用整合於_個安置設__&lt;_ 式治療方法的流程圖。 圖2為本案較佳實施例之電磁式治療用具之示意圖。 圖3為本案較佳實施例之小型化的電路結構圖。 圖4為本案較佳實施例之波形傳遞至目t 义圖5為說明PMF預治療結果之長條圖,其中5i為無施加,於為 之前施力σ PMF,53為之後施加PMF 、 圖6為說明特定PMF結果之長條圖。 圖7為說明持續性PMF結果之長條圖。 【元件編號之說明】 201微型控制電路 202連接器 203產生設備 300微型控制電路 33 200824744 TPPO/PUS213-001There is an increase in the number of nicotinary neurons that survive. Other treatments have no significant side effects on neuronal population. The results are shown in Figure 6, where the treatment pattern is shown on the X-axis and the number of neurons is shown on the γ-axis. "As shown in Figure 7, the treatment of the towel is shown in the road, the number of neurons is shown on the Y-axis, and this B ^ 'PMF signals D and E decrease the concentration in the serum medium, and the number of amines & 46% right. Both sides of the statement are configured with burst width 3__ interest rate is 5/sec and 1/sec respectively. Obviously, the signal ^ is continuously _ Authentic execution, but the signal Ε is only executed once: 2 hours before the removal of 29 200824744 TPPO/PUS213-001 is the same (Mc see above), resulting in the value of the fruit sold <樵 and 48%). Due to the reduction of serum in the media, the availability of nutrients and growth factors is reduced, after going through The synthesis or release of these factors is induced by the cultivation of these factors. The role of this part of the experimental 6-inducing layer-induced toxicity produces a clearly described mechanism of dopamine cell death. This molecule is transported by high affinity dopamine. The daughter enters the cell and inhibits the enzyme complex j of the granulosa, and then kills these nerves via oxidative stress. The culture is treated with 25 μΜ 6-0 HDA after continuous or acute pmp exposure. Its towel Shown on the X-axis, the number of neurons is not on the γ-axis. Toxins kill about 8% of dopamine neurons in the absence of PMF treatment. Use under PMF (power: 6; burst width = 3Q_sec; frequency = 1) /sec), the survival of nerve cells is greatly increased compared to the only 6-〇HDA (2.6-fold; Ρ£〇·〇2), and the neuroprotection developed for Parkinson's disease is presented. The method is particularly relevant, and the oral 60 0A is used to impair dopamine in the Parkinson's standard scorpion animal model, and the binary and sputum mechanisms are somewhat similar to those of Parkinson's disease itself. In this example, electromagnetic field energy is used to stimulate the angiogenesis of the tube in an in vivo model. Two different signals are used, one according to the prior art configuration and the other according to the embodiment of the invention. One hundred and eight each The e-Dawley male, which weighs about 3 grams, is divided into nine groups. All animals are anesthetized with ketamine/acepr〇mazine/Stad〇1 mixture 〇·1 cc/g. Using sterile surgical techniques with microsurgical techniques Each animal takes 30 200824744 TPP O/PUS213-001 A 12 to 14 cm tail artery. The artery is filled with 60 U/ml heparinized salt to remove all blood or emboli. These average diameters are 4 mm to 0.5 mm of the tail vessel and then sutured to A cross-section of the right thigh bone artery closest to the end, using a two-to-end joint method to create a thigh bone arterial ring. The resulting loop is then placed in a subcutaneous pocket made in the animal's gastrointestinal tract / hamstring muscle tissue. The squirrel incision was sutured with 4-0 Ethilon. Then each animal was randomly placed into one of nine groups: groups 1 to 3 (control group), these mice were not connected _ subject to electromagnetic field treatment and killed after 4,8 weeks; groups 4 to 6, treatment each Twice a day, mother 30 points #里' use 〇· 1 Gauss electromagnetic field lasts 4,8,12 weeks (animals are killed after another 4,8,12 weeks); treatment twice daily, 3 times each time Minutes, using a 2 〇 Gauss electromagnetic field lasted 4 ' 8 ' 12 weeks (animals were killed after 4, 8, 12 weeks). Pulsed electromagnetic energy is applied to the treated group, using a slap made in accordance with an embodiment of the present invention. The animals in the test group received twice daily treatment, each go minutes, 〇. 1 Gauss or 2.0 Gauss, using short pulses (2 milliseconds to 20 milliseconds) 27.12 MHz. The object is placed over the top of the applicator and is restrained to ensure proper treatment. The ketamine/acepromazine/Stadol was beaten in the pneumoperitoneum and heparin 100 g was administered intravenously for re-anesthesia. Using a previous murine incision, the femoral artery can be clearly discerned from the plate's thigh/tail arterial ring and then proximally isolated from the junction, and the blood g is clamped to kill the animal. This circle was injected with a colored dressing with a salt of 0·5 cc to 1·Occ: a ribbed catheter and clamped. Carefully cut the skin above the abdomen and sway it*. The quantification of vascular puncture is quantified by the method of intraluminal administration of the surface of the vascular endothelium 31 200824744 TPPO/PUS213-001. After the money SPSS statistical analysis k body for all results were analyzed. In the blood &amp; newborn gamma treatment 彳 | and did not, practice the old gas, the most obvious _ difference occurred in the brother 4 weeks. During this period, no new blood vessel formation was observed in the control group. However, the group treated with the solidification had a similar sigmoidal evidence for angiogenesis in G cm2 versus 142 ± G 8Q — (p < 01). . These areas appear when the milk is distributed in sections along the sides of the - arterial ring. At 8 weeks, the control group began to exhibit an angiogenic effect, measured in Φ.7 〇·82 cm2. The two treated groups again had almost the same statistical significance at 8 weeks (p &lt; 0. coffee) vascular exposure, 3.57 ± L 82 cm2 for G. 〗 chest contrast group ' 3. 77 ± 1.82 cm2 for the 2. Ggauss group. At 12 weeks, the animals in the control group exhibited an angiogenic effect of 1.75±0.95αη2, while the 〇. i § 面 group exhibited 5.95 ± 3· 25 cm2, 2.0 gauss group showed 6. 2〇± &amp; 95 - the formation of dendritic blood vessels. Again, the two treatment groups again showed a statistically significant (P &lt; 0 001) finding comparable to the control group. • The results of these experimental studies show that the electromagnetic field stimulation of an isolated arterial ring according to the embodiment of the present invention greatly increases the angiogenesis effect in a living mouse model. Increased angiogenesis is shown in the treatment group. No difference was found in the two Gaussian level tests, as in the present invention. In the above specific embodiment, the integrated coil device for treating human and animal cells, tissues, and organs by electromagnetic field and the method thereof can be used without leaving the day and the moon. 32 200824744 ^ TPPO/PUS213- 001 &amp; This feature is all kinds of tenderness. The tree-shaped axis is limited by the scope of the patent application of the attached file, and the change of the face-to-face is required to be included in the present invention. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a flow chart showing the use of a __&lt;_ type of treatment method integrated into a preferred embodiment of the preferred embodiment of the present invention. 2 is a schematic view of an electromagnetic therapeutic apparatus according to a preferred embodiment of the present invention. 3 is a circuit diagram showing the miniaturization of the preferred embodiment of the present invention. Figure 4 is a perspective view of the preferred embodiment of the present invention. Figure 5 is a bar graph illustrating the PMF pre-treatment results, wherein 5i is no application, before applying force σ PMF, 53 is after applying PMF, Figure 6 A bar graph to illustrate the results of a particular PMF. Figure 7 is a bar graph illustrating the results of persistent PMF. [Description of component number] 201 micro control circuit 202 connector 203 generating device 300 micro control circuit 33 200824744 TPPO/PUS213-001

301鋰電池 302可調變電源供應器 303微型控制器 304存儲電容器 305脈衝成形機 306脈衝相位時間控制器 307電壓層級轉換次級電路 | 308可調變的HEXFET 309輸出 400波形 401脈衝 402突發 403期間 404振幅封包 34301 lithium battery 302 adjustable power supply 303 microcontroller 304 storage capacitor 305 pulse forming machine 306 pulse phase time controller 307 voltage level conversion secondary circuit | 308 adjustable HEXFET 309 output 400 waveform 401 pulse 402 burst 404 amplitude packet 34 during 403

Claims (1)

200824744 TPPO/PUS213-001 十、申請專利範圍·· 1· 一種對動物和人類進行電磁治療的方法,該方法包含以下步驟: 根據具至少一個的一波形參量的一數學模型,配置至少一個的一 波形,該波形被與一目標路徑結構結合; 選擇至少一個的該波形參量的一值,以在該目標路徑結構中在該 目標路徑結構背景活性上,使至少一個的該波形被配置為可偵測的; 由所配置的該波形,產生一電磁式信號; 將至少一個的一結合設備與一安置設備整合以放置在與該目標路 徑結構接近之位置;以及 以至少-個的該結合設備結合該電磁式信號至該目標路麟構。 2.如申請專利細第丨撕述之對動物和人舰行電磁治療的方法, 其中至少-個的該波形參量包含:至少一個的一頻率組成參量1配置 至=個的該波形為約重複刻.⑽z至⑽驗之間、—突發振 包翏$其由-數學定義的振幅函數而來、 :田、 學定義__賴_魏、數 學定義的振幅函數在該目標嶋構中約在二::據魏 圍内變化,以及一高峰誘發磁場參量依據—數學定羞^ 範 路徑結構中約在1虹至G.1 了範_變化。“數在該目標 和人類進行軸治療的方 3.如申請專利範圍第2項所述之對動物 200824744 TPPC/PUS213-001 法,其中該定義的振幅函數包含:至少—個的v頻率函數、一醜函 數、一混亂函數、以及一指數函數。 也如申請專利細第i項所述之對動物和人類進行電磁治療的方 法丄其中如擇至少-個的該波形參量的一值的步驟更包含選擇滿足 一域對雜訊比模s之至少、一個的該波形參量的一值的步驟。 • 5·如申請專利範圍第i項所述之對動物和人類進行電磁治療的方法, 其中該選擇至少一個的該波形參量的—值的步驟更包含選擇滿足一功 率信號對雜訊比模型之至少-個的該波形參量的—值的步驟。 6.如申5青專利乾圍第j項所述之對動物和人類進行電磁治療的方 ^其中該目標雜結構包含至少—個的分子、細胞、組織、、器官、 離子、及配位子。 、、·如申4翻祕第1撕狀對軸和人麵行電磁治療的方 ^其中更包含結合離子與雜子至轉分子以麵職成長、修復、 及維護之步驟。 ^如申請專利範圍第7項所述之對動物和人類進行電磁治療的方 去’其中該離子與配位子的結合包含調控妈與簡素的結合。 36 200824744 TPPO/PUS213-001 之製造。 .如申請專利範圍第7項所述之對動物和人類進行電磁治療的方 法,其中該離子與配位子的結合包含調控在目標路徑結構中細胞激素 Π.如申請專利細第7項所述之對動物和人類進行電磁治療的方 法’其中雜子細奸的齡包含離無織絲、健、維護相 關的生長因子及細胞激素。 12.如申請專利細第7項所述之對動物和人類進行電磁治療的方 法’其中_子與S她子的結純含输血錄生與新生血管作用以 進行目標路徑結構之成長、修復、及維護。 13·如申睛專利範圍第7獅述之對絲和人類進行電磁治療的方 法其中该離子與配位子的結合包含調控血管新生與新生血管作用以 進行腦血管疾病之治療。 37 200824744 TPPO/PUS213-001 14·如申請專利範圍第7項所述之對動物和人類進行電磁治療的方 法’其中該離子與配位子的結合包含調控生長因子與細胞激素以進行 睡眠失調之治療。 如申請專利範圍第7項所述之對動物和人類進行電磁治療的方 法,其中該離子與配位子的結合包含調控血管新生與新生血管作用以 進行睡眠失調之治療D 瓜如申料利細第7撕狀_姊人親偶磁治療的方 法,其中該離子與配位子的結合包含經由增加深目民階段的長度以調控 人類生長激素的釋出。 17·如申睛專利乾圍第i項所述之對動物和人類進行電磁治療的方 法’其中更包含將_和草藥纖用在目標雜結構以進行組織的生 長、修復、及維護。 ^申糊細第Π撕狀對麵和人_迦治療的方 ㈣其___含至少,局膽物、局部乳膏、及局 如申請專利細第1撕述之對動物和人類進行電磁治療的方 38 200824744 TPPO/PUS213-001 法,其中更包含將藥劑和草藥劑應用在目標路徑結構以進行神經衰退 疾病之治療。 2〇.如申請專利範圍第1項所述之對動物和人類進行電磁治療的方 法,其中該安置設備至少包含下列之一.' 、 療表面、治療結構、治療 設備、手術包紮、解剖支持物、解剖纏繞物、傷口包紮、塾、座塾、 床墊、鞋子、㈣、軒、 細胞的結構物。 21.如申請專利範圍第2〇項所述之對動物和人類進行電磁治療的方 法’其中該衣著包含至少下列之—:服裳、時尚配件、鞋子、機子、 及腳部用品。 22·如申凊專利細第i項所述之對動物和人類進行電磁治療的方 法,其中該結合設備包含至少一導線和一線圈。 议如申請專利範圍第!項所述之對動物和人類進行電磁治療的方 法其中更包含將標準物理、冶療療法應用在一身體區域之治療的步驟。 24如申料娜圍第23撕述之對祕和人類進行電磁治療的方 法其中標準物理治療療法包含至少下列之一:熱、冷、壓力、按摩 39 200824744 TPPO/PUS213-001 及運動。 A如申請專利賴第i項所述之對動物和人類進行電磁治療的方 其中找飼啦倾魏雜鼓錄触少—烟該結合設 1鸯的步驟。200824744 TPPO/PUS213-001 X. Patent Application Scope 1. A method for electromagnetic treatment of animals and humans, the method comprising the steps of: arranging at least one according to a mathematical model having at least one waveform parameter a waveform that is combined with a target path structure; selecting at least one value of the waveform parameter to cause at least one of the waveforms to be detectable in the target path structure over the target path structure background activity Detecting; generating an electromagnetic signal from the configured waveform; integrating at least one of the bonding devices with a placement device to be placed in proximity to the target path structure; and combining at least one of the bonding devices The electromagnetic signal is applied to the target path. 2. The method of electromagnetic therapy for animals and human ships, as claimed in the patent specification, wherein at least one of the waveform parameters comprises: at least one frequency component of the parameter 1 is configured to = the waveform is approximately repeated Engraved. (10)z to (10) test, - burst vibration package 其 $ which is derived from the mathematically defined amplitude function, : Tian, learning definition __ 赖_魏, mathematically defined amplitude function in the target structure In the second:: according to Wei Wei changes, and a peak induced magnetic field parameters basis - mathematics fixed shame ^ Fan path structure in about 1 rainbow to G.1 van _ change. "The number of the axis treatment in this target and humans. 3. For the animal 200824744 TPPC/PUS213-001 method described in claim 2, wherein the defined amplitude function comprises: at least one v-frequency function, An ugly function, a chaotic function, and an exponential function. The method for electromagnetic treatment of animals and humans as described in the patent item i, wherein the step of selecting at least one value of the waveform parameter is more The method includes the step of selecting a value of the waveform parameter that satisfies at least one of the domain-to-noise mode s. • 5. The method for electromagnetic treatment of animals and humans as described in claim i, wherein The step of selecting at least one value of the waveform parameter further comprises the step of selecting a value that satisfies at least one of the power signal to the noise ratio model. 6. For example, the sub-item of the claim 5 The method for electromagnetic treatment of animals and humans, wherein the target heterostructure comprises at least one molecule, cell, tissue, organ, ion, and ligand. 1 tearing on the axis and human face electromagnetic treatment method ^ which further includes the steps of combining ions and heterozygote to the trans-molecule for face growth, repair, and maintenance. ^As described in the scope of claim 7 The practice of electromagnetic therapy with humans' where the combination of the ion and the ligand contains a combination of regulation of the mother and the simple element. 36 200824744 Manufacture of TPPO/PUS213-001. As described in claim 7 for animals and A method of electromagnetic therapy in humans, wherein the binding of the ion to the ligand comprises modulating a cytokine in the target pathway structure. The method of electromagnetic treatment of animals and humans as described in the seventh application of the patent application The age of rape includes growth factors and cytokines related to non-woven silk, health and maintenance. 12. The method of electromagnetic treatment for animals and humans as described in the patent application item 7 The knot contains pure blood transfusion and neovascularization to carry out the growth, repair, and maintenance of the target path structure. 13·If the scope of the patent application is 7th, the lion will perform electromagnetic therapy on silk and humans. The method wherein the binding of the ion to the ligand comprises regulating angiogenesis and neovascularization for the treatment of cerebrovascular diseases. 37 200824744 TPPO/PUS213-001 14 · For animals and humans as described in claim 7 A method of performing electromagnetic therapy, wherein the binding of the ion to the ligand comprises the treatment of a growth factor and a cytokine for the treatment of sleep disorders. The method for electromagnetic treatment of animals and humans as described in claim 7 of the patent application, wherein The combination of the ion and the ligand includes a method for regulating angiogenesis and neovascularization for sleep disorder, and a method for treating the symphysis, wherein the ion and the ligand are used. The combination involves the regulation of the release of human growth hormone by increasing the length of the deep eye stage. 17. The method of electromagnetic treatment of animals and humans as described in item yi of the patent application PCT, which further includes the use of _ and herbal fiber in the target heterostructure for tissue growth, repair, and maintenance. ^申糊细Π Π 状 和 和 和 和 和 和 和 和 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦 迦The party 38 200824744 TPPO/PUS213-001 method, which further comprises the application of medicaments and herbal agents to the target path structure for the treatment of neurodegenerative diseases. 2. The method of electromagnetically treating animals and humans as described in claim 1, wherein the setting device comprises at least one of the following: ', therapeutic surface, therapeutic structure, therapeutic device, surgical dressing, anatomical support , anatomical entanglement, wound dressing, sputum, seat scorpion, mattress, shoes, (four), Xuan, cell structure. 21. A method of electromagnetic treatment of animals and humans as described in claim 2, wherein the garment comprises at least the following: clothing, fashion accessories, shoes, machines, and foot items. 22. A method of electromagnetically treating an animal and a human as described in claim i, wherein the bonding device comprises at least one wire and a coil. If you apply for a patent scope! The method of electromagnetic treatment of animals and humans as described therein further includes the step of applying standard physical and therapeutic therapies to treatment in a body region. 24 The method of electromagnetic therapy for secret and human beings, as stated in the 23rd of the application, wherein the standard physical therapy includes at least one of the following: heat, cold, pressure, massage 39 200824744 TPPO/PUS213-001 and exercise. A. For example, the method of applying electromagnetic therapy to animals and humans as described in the application of the patent Lai i, which is the step of setting up the feeding and digging the drums. 2=如25項職之_姊人_行辆治療的方 …其中該電磁式信號是由至少下列之—所產生:相同組態的至少一 個的該波形’以及不同組態的至少—個的該波形。 沈如巾請專利細第丨項所述之對動物和人類進行電磁治療的方 ^,其中更包含連續產生1磁式信號至多數的至少—個的該結合設 備之步驟。 /申請專利範圍第27項所述之對動物和人類進行電磁治療的方 …其中該電磁式信號是由至少下列之—所產生:相同組態的至少一 個的該波形,以及不同組態的至少—個的該波形。 說如申請專利麵第i項所述之對動物和人類進行電磁治療的方 ^ ’其中更包含多轉輸1磁雜齡錄岐少—個的該結合設 備之步驟。 200824744 TPPO/PUS213-001 3〇.如申請專利範圍第29項所述之對動物和人類進行電磁治療的方 法,其中該電磁式信號是由至少下列之一所產生:相同的至少一個的 配置的該波形,及不同的至少一個的配置的該波形。 礼如申請專利細第1項所述之對動物和人類進行電磁治療的方 t ’其中更包含將標準醫學療法和非標準醫學療法至少其中之-與該 氣石兹式治療誘發裝置附屬使用的步驟。 申請專利範圍第31項所述之對動物和人類進行電磁治療的方 …其中標準醫學療法包括至少下列之L植、 請專利細第1項所述之對動物和人類進行電磁治療的方 ^射找德鮮醫轉絲_準辉療社少財之一轉 兒石兹式治療誘發裝置連結使用的步驟。 ^ /、中標準物理療法包括至少下列一· /、 熱、冷、鱗、价嫩。㈣侧、正壓力、 祗如申請專利範圍第1項所述之對動物和人類 去’其中結合該電磁式信號魏目標路、% 的方 包含防止細胞和 200824744 TPPO/PUS213-001 組織的損失和退化之結合。 36·如申請專利範圍第1項所述之對 、 勒物和人類進行電磁治療的方 法,其中結絲獅 組織活性之結合。 37·如申請專利範圍第1項所述之對 丁勒物和人類進行電磁治療的方 法,其中結合該電磁雜號魏 量之結合。 见如申請專織_丨賴狀_細人酿行賴治療的方 法:其中結合該電磁式信號至該目標構之步驟包含防止細胞神 經元之結合。 讥如申請專利範圍第i項所述之對動物和人類進行電磁治療的方 法,其中結合該電磁式信號至該目標物吉構之步驟包含增加神經元 數量之結合。 肌如申請專利細第1項所述之對動物和人類進行電磁治療的方 法,其中結合該電磁式信號至該目標路徑結 神經元惡化之結合。 上腺 42 200824744 TPPO/PUS213-001 41·如申請專利麵第!項所述之對動物和人類進行電磁治療的方 法’其中結合該電磁式信號至該目標路徑結構之步驟包含增加腎上腺 神經元數量之結合。 42.如申請專利細第i項所述之對動物和人類進行電磁治療的方 法’其中由配置的至少-個的該波形所產线磁式信號的步驟包含可 程式化地產生該電磁式信號。 43· —種用於動物和人類的電磁式治療裝置,其中包含: -波形配置方式,用以配置至少-侧波形以結合至―目標路徑 結構,依據-數學模式;該數學模式具有至少一個的波形參量可供選 擇’以使至少一個的該波形在該目標路徑結構中在該目標路徑結構背 景活性之上配置為可偵測的。 至少-__結合設備’該結合設備經由至少—侧連結方式連 結至該波形配置方式,用以由所配置的至少—個的該波形產生一電磁 式信號,並用以結合該電磁式信號至該目標路握結構;以及 -安置設備’其中至少一個的該結合設備為該安置設備的一部份。 44.如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置,其中至少一個的該波形參量至少包含下列之一: 43 200824744 TPPO/PUS213-001 ^鮮'喊參量,其赠-數料數崎封_個_ 在約0·01Ηζ至100MHz之間; -突發振幅封包參量,其依照—數學定義的振幅函數而得. -突舰參量’其依據-數學定她度顺在雜重複處 變化; -高峰麵綱,細目標路函數 中在約1 μν/cm至100 mV/αη間變化;以及 嫩她胁該目標路 函數中在約1 liT至0· 1T間變化。 數函數、一混亂函數、及一指數函數 如申請專利雜43項所述之嶋物和人_電磁式治療裝 匕其中軟義的振幅函數包含至少下列之—:—17頻率函數、一對 46. 如申請專利細第43項所述之用於動物和人類的電磁式治療裝 ’其中至少-個的該波形參量的值更包含可滿足信號雜訊比模型的 至少一個的該波形參量的一值。 47.如申睛專利範圍第43項所述之用於動物和人類的電磁式治療裝 y其中至少-個的該波形參量的值更包含可滿足功率信號雜訊比模 !的至少一個的該波形參量的一值。 44 200824744 TPPO/PUS213-001 48·如申明專利範圍第43項所述之用於動物和人類的電磁式治療裝 置’其中該目標路徑結構包含至少下列之一:分子、細胞、組織、器 官、離子及配位子。 49·如申凊專利範圍第43項所述之帛於動物和人類的電磁式治療襄 置,、中L號疋被電感式地結合至目標路徑結構,其中舞與娜弓素的 藝結合是被調控的。 ' 50.如申請專利細第43項所述之用於動物和人類的電磁式治療裂 置’其中信號是被電容式地結合至目標雜結構,其中输調舞素 結合是被調控的。 、、 51·如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置’其中域被電感雜結合至目標路徑結構以調控與該目標路徑結 構生長、修復、及維護錢之生長目子轴胞激素的產生。 52·如申睛專利細第51項所述之用於動物和人類的電磁式治療裝 摆/、中生長因子包含至少下列之一:成纖維細胞生長因子、血小板 釋放生長肝、及介自f生細子。 45 200824744 说如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置,其中信號被電容式地結合至目標路徑結構以調控無目摔柄 構生長、修復、及維護有關之生長因子或細胞激素的產生。 54如申糊娜53獅㈣糊^爾磁式治療裝 置,其中蝴子包含至少下列之—:成纖維細胞蝴子、血小板 釋放生長因子、及介白質生長因子。 55.如申請專利細第43項所述之用於動物和人類的電磁式治療裝 “中U虎被电谷式地結合至目標路徑結構以雛對於骨路斷裂治 療之血管新生與新生血管作用。 ^ 〇 士申明專利細第43項所述之用於動物和人類的電磁式治療裝 置/、中U虎被電感式地結合至目標路徑結構以雛對於骨路斷裂治 療之灰管新生與新生血管作用。 &lt; σ ,士申明專利乾圍第43項所述之用於動物和人類的電磁式治療裝 :、中彳為i電感规結合___祕雛騎編之 血管新生與新生血管作用。 ,、 58· 如申請專利範圍第 奶項所述之用於動物和人類的電磁式治療裝 46 200824744 TPPO/PUS213-OOI 療之 血置管:=:r合—‘ m請Γ娜43卿物於叫人類幅式治療裝 置其中仏就被電感式地結合至目標路 療之血管触域生碎侧。&amp;結細雛躲崎疾病治 60.如申請專利範圍第43項所述之 置,复中仁心年〜 、動物和人類的電磁式治療裝 卜於血管疾病治 ”中域被%谷式地結合至目標雜結構以調控鄴 療之血管新生與新生金管作用。 請專利範圍第43項所述之用於動物和人類的電磁式治療裝 二中信號被電容式地結合至目標峨構以調控 化 疾病治療之血管触絲生血管侧。 6二7請專利_43項所述之_物和人_磁式治療裝 ’、中域被電感式地結合至目標路徑結構以調控對於睡眠失調治 療之血管新生與新生血管作用。 /σ 女申明專利細帛43項所述之肖於動物和人類白々電磁式治療裝 置其中信號被電容式地結合至目標路徑結構以調控對於睡眠失調治 47 200824744 TPPO/PUS213-001 療之血管新生與新生血管作用。 64·如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置’其中信號被電感式地結合至目標路徑結構經由增加深眠時間以調 控人類生長因子之製造。 65·如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 鲁 置’其中信號被電容式地結合至目標路徑結構經由增加深眠時間以調 控人類生長因子之製造。 66·如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置,其中電磁式治療裝置係被製成輕量並可攜帶的。 67·如申睛專利細第43項所述之帛於動物和人類的電磁式治療裝 •置,其中該安置設備至少包含下列之—:治絲面、治療結構、治療 設備、手術包紮、解剖支持物、解顺繞物、傷口包紮、墊、座塾、 床墊子輪椅Pf、衣著、運軸品和可接近放置於活組織和 細胞的結構物。 ===== 48 200824744 及腳部用品 TPPO/PUS213-001 69.如申請翻軸f 43 置,其中該連結方式包含至少;;=於動物和人類的電磁式治療裝 方式、和直接連結方式1之―:導線、無線信號傳送和接收 43 式 置其中錢形酉己置方式為可程式化的。 置方式在—段縣蚊的__遞至卜個脈衝磁 場1吕疏0 72·如申請專利範圍第43項所述之用於動物和人 置/、中波形配置方式在一段隨機的時間内傳 號。 類的電磁式治療裝 遞至少一個脈衝磁場信 74如申請專利範圍帛73項所述之肖於動物和 人類的電磁式治療裝 49 200824744 TPPO/PUS213-001 如申請專利細第43項所述之用 置,其中更包含針物和草藥劑之—傳遞方式。、磁式治療裝 第43項所述之用於動物和人類的電磁式治療裝 ,、中更包綺對標轉學治叙-傳遞方式。 7置?· 綱範圍第76項所述之用於動物和人類的電磁式治療裝 管新I ^醫學治療包括至少下列之—的治療:新生血管作用、血 ,生、心性和良性情況的免疫反應、及渗出之治療。 ,專利瓣43項所述之用於動物和人類的電磁式治療裝 “中该波形配置方式係與該安置設備整合。 磁式治療裝 可拋棄的之其中一 79.如申請專利細第43項所述之用於動物和人類_ 置’其中該安置設備至少為可攜帶的、可植入的、 種。 80 如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置,其中更包含多數的至少—個的結合設備,用以由至少—個配置的 50 200824744 TPPO/PUS213-001 波形而同時產生至少一個的電磁式信號。 乩如申請專利範圍第8〇項所述之用於動物和人_電磁式治療裝 置,其中至少-個的配置的該波形至少包含下列之一:至少一個的相 同配置的該波形,及至少一個的不同配置的該波形。 ° 82.如申請專利範圍第43項所述之用於動物和人_電磁式治療裝 ··置,其中更包含多數的至少一個的結合設備,用以由至少一個配置的 波形而連續產生至少一個的電磁式信號。 83·如申請專利細第82項所述之帛於動物和人類的電磁式治療裝 置其中至少一個的配置的該波升饱含至少下列之一 ··相同的至少一 個的配置的該波形,及不同的至少—個的配置的該波形。 • 84· *申請專利細第43項所述之祕動物和人類的電磁式治療裝 • 置’、中更包含多婁丈的至少一個的結合設備,用以由至少-個的配置 - 的波形多路傳輸至少一個的電磁式信號。 85·如申請專利範圍第84項所述之用於動物和人類的電磁式治療裝 置,其中至少一個的配置的該波形包含至少下列之一:相同的至少一 個的配置的該波形,及不同的至少一個的配置的該波形。 51 200824744 TPPO/PUS213-001 86. 如申請專利細第43項所述之藤動物和人_電磁式治療裝 置,其中彳§號是電感式地結合至該目標路徑結構。 87. 如申請專利範圍第43項所述之藤動物和人類的電磁式治療裝 置,其中信號是電容式地結合至該目標路徑結構。 ^ 88.如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置’其中信號是電感式地結合至該目標路徑結構以防止細胞和組織的 損失和衰退。 89·如申請專利麵帛43項所述之騰動物和人類的電磁式治療裝 置,其中信號是電容式地結合至該目標路徑結構以防止細胞和組織的 損失和衰退。 9〇·如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置,其中信號是電感式地結合至該目標路徑結構以增進細胞活性。 91·如申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置’其中信號是電容式地結合至該目標路徑結構以增進細胞活性。 52 200824744 TPPO/PUS213-001 92. 如申請專利範圍第43項所述之雜動物和人類的電磁式治療裝 置,其中信號是電感规結合至該目標路徑結構以增加細胞數量。 93. 如申請專利細第43項所述之用於動物和人類的電磁式治療裝 置’其中信號是電容式地結合至該目標路徑結構以增加細胞數量。 94. 如申請專利細第43項所述之用於動物和人_電磁式治療裝 置’其中信號是電感式地結合至該目標構以防止神經元衰退。 95. 如申__第43項細㈣於動物和人_電磁式治療裝 置,其中域是電容式地結合_目標路 9J· 、中域是域式地結合· 〇 ,/、中嫩電容細。 經元 衰退:K叙4式聽合至細_,爾止腎上腺神 53 200824744 TPPO/PUS213-001 申請專利範圍第43項所述之用於動物和人類的電磁式治療裝 置’其中錢編綱_______ 哀退。 100•如申請專利範圍第43項所述 罟甘+ K用於動物和人類的電磁式治療裝 ,/、中信號是電感式地結合至該目^ 數量。 裇路後結構以增加腎上腺神經元 101·如申請專利細第43項所述之 置,其中信號是電容式地結合至_2物和人類的電磁式治療裝 數量。 V侵結構以增加腎上腺神經元 102.如申請專利範圍第43項 置’其中該波形配置方式為可程式化的,物和人_電磁式治療裝 542 = such as 25 jobs _ 姊 _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The waveform. The method for electromagnetic treatment of animals and humans as described in the patent specification, further includes the step of continuously generating one magnetic signal to at least one of the plurality of combined devices. / The method of electromagnetic therapy for animals and humans as described in claim 27 of the patent application, wherein the electromagnetic signal is generated by at least the following: at least one of the same configuration, and at least one of the different configurations The waveform of one. It is said that the method of electromagnetic treatment for animals and humans as described in item i of the patent application further includes the step of multi-transferring one magnetic recording age. The method of electromagnetically treating animals and humans according to claim 29, wherein the electromagnetic signal is generated by at least one of the following: at least one of the same configuration. The waveform, and the waveform of the different at least one configuration. The method of electromagnetic therapy for animals and humans as described in the first application of the patent application, which further includes the use of at least one of standard medical therapy and non-standard medical therapy with the gas stone treatment-inducing device. step. Patent application for the electromagnetic treatment of animals and humans as described in item 31 of the patent application. The standard medical therapy includes at least the following L-plants, and the method of electromagnetic treatment for animals and humans as described in Patent Item 1 Look for the German fresh medicine to turn the silk _ quasi-radiation treatment of a small amount of money to turn the stone Shiz treatment treatment device connected to use the steps. ^ /, medium standard physiotherapy includes at least one of the following /, hot, cold, scale, and tender. (iv) Side, positive pressure, as described in item 1 of the patent application scope for animals and humans to 'incorporate the electromagnetic signal Wei target path, % of the party contains the cells and the loss of the 200824744 TPPO/PUS213-001 tissue and a combination of degradation. 36. A method of electromagnetic treatment of lees, humans and humans as described in claim 1 of the scope of patent application, wherein the combination of the activity of the lion's tissue. 37. A method of electromagnetic treatment of a Dingle object and a human as described in claim 1 of the patent application, in which a combination of the electromagnetic code is combined. See the method of applying for special treatment _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ For example, the method of electromagnetically treating animals and humans as described in claim i, wherein the step of combining the electromagnetic signal to the target comprises increasing the combination of the number of neurons. The method of electromagnetically treating animals and humans as described in the above-mentioned patent application, wherein the electromagnetic signal is combined with the deterioration of the target path junction neuron. Upper gland 42 200824744 TPPO/PUS213-001 41·If you apply for a patent! The method of electromagnetically treating animals and humans as described in the section wherein the step of binding the electromagnetic signal to the target pathway structure comprises increasing the binding of the number of adrenal neurons. 42. A method of electromagnetically treating an animal and a human as described in the application of the patent item i, wherein the step of generating a magnetic signal from at least one of the configured waveforms comprises programmably generating the electromagnetic signal . 43. An electromagnetic treatment device for animals and humans, comprising: - a waveform configuration for configuring at least a side waveform to be coupled to a "target path structure," according to a mathematical mode; the mathematical mode having at least one The waveform parameter is selectable 'such that at least one of the waveforms is configured to be detectable in the target path structure above the target path structure background activity. At least the combination device is coupled to the waveform configuration via at least one side connection for generating an electromagnetic signal from the configured at least one waveform and for combining the electromagnetic signal to the The target road grip structure; and the at least one of the placement devices are part of the placement device. 44. The electromagnetic therapeutic apparatus for animals and humans according to claim 43, wherein the waveform parameter of at least one of the at least one of the following: 43 200824744 TPPO/PUS213-001 ^Fresh 'shouting parameter, The number of gift-numbers is _ _ _ between about 0·01Ηζ to 100MHz; - the burst amplitude packet parameter, which is obtained according to the mathematically defined amplitude function. - The ship's parameter' is based on the mathematics Variations in the sinusoidal repeats; - peak profile, varying between about 1 μν/cm and 100 mV/αη in the fine target path function; and between about 1 liT and 0·1T in the target path function . The number function, a chaotic function, and an exponential function are as described in claim 43. The amplitude function of the soft sense includes at least the following: - 17 frequency function, a pair of 46 The electromagnetic therapy device for animals and humans as described in claim 43 is characterized in that at least one of the waveform parameters further includes one of the waveform parameters satisfying at least one of the signal noise ratio models. value. 47. The electromagnetic therapy device for animals and humans according to claim 43 of claim 4, wherein at least one of the values of the waveform parameter further comprises at least one of the power signal noise modulo! A value of the waveform parameter. </ RTI> </ RTI> </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; And matching seats. 49. The electromagnetic treatment device for animals and humans described in Item 43 of the patent scope of the application, the L-type 疋 is inductively coupled to the target path structure, wherein the combination of dance and lycopene is Regulated. 50. An electromagnetic therapeutic rupture for animals and humans as described in claim 43 wherein the signal is capacitively bound to the target heterostructure, wherein the transflex binding is regulated. 51. The electromagnetic therapeutic device for animals and humans as described in claim 43 wherein the domain is inductively coupled to the target path structure to regulate growth, repair, and maintenance of the target path structure. Growth of the production of axonal hormones. 52. The electromagnetic therapy device for animal and human use as described in claim 51, the medium growth factor comprises at least one of the following: fibroblast growth factor, platelet release growth liver, and inter Born. 45 200824744 An electromagnetic treatment device for animals and humans as described in claim 43 wherein the signal is capacitively coupled to the target path structure to regulate the growth, repair, and maintenance of the eyeless structure. Growth factor or production of cytokines. 54 such as the Shenzi Na 53 lion (four) paste magnetic treatment device, wherein the butterfly contains at least the following - fibroblast butterfly, platelet release growth factor, and white matter growth factor. 55. The electromagnetic therapeutic device for animals and humans described in the patent application No. 43, "U-Tiger is electrically connected to the target path structure to protect the angiogenesis and neovascularization of the bone fracture ^ Gentleman's claim for the electromagnetic treatment device for animals and humans described in Item 43 of the patent, the U-infant is inductively coupled to the target path structure, and the gray tube newborn and newborn for the treatment of bone fracture Vascular effect. &lt; σ , 申 申 申 申 申 申 申 申 申 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁 电磁Acting, , 58· Electromagnetic treatment equipment for animals and humans as described in the scope of the patent application No. 46 200824744 TPPO/PUS213-OOI blood tube:=:r--m mΓ娜43 The object is called a human-type treatment device, in which the sputum is inductively coupled to the pulverized contact area of the target road therapy. &amp; fine-cutting and escaping disease treatment 60. As described in claim 43 Set, Fuzhong Renxin Year ~, animals and people An electromagnetic treatment apparatus Bu "domain is bound to the valley% target hybrid structure FSC neovascularization angiogenesis regulation Ye therapeutic treatment of vascular diseases acting. The electromagnetic therapy device for animals and humans described in Item 43 of the patent scope is capacitively coupled to the target structure to regulate the vascular contact surface of the disease treatment. 6 2 7 The patent and the human _ magnetic therapy device, the mid-domain is inductively coupled to the target pathway structure to regulate the angiogenesis and neovascularization for sleep disorder treatment. /σ Women's Declared Patent 帛 帛 于 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物With the role of new blood vessels. 64. An electromagnetic therapeutic device for animals and humans as described in claim 43 wherein the signal is inductively coupled to the target pathway structure to increase the production of human growth factors by increasing deep sleep time. 65. An electromagnetic therapeutic device for animals and humans as described in claim 43 wherein the signal is capacitively coupled to the target pathway structure to increase the production of human growth factors by increasing deep sleep time. 66. An electromagnetic treatment device for animals and humans as described in claim 43 wherein the electromagnetic treatment device is made lightweight and portable. 67. The electromagnetic treatment device for animals and humans as described in Item 43 of the application of the patent, wherein the installation device comprises at least the following:: silk surface treatment, treatment structure, treatment equipment, surgical dressing, anatomy Support, disintegration, wound dressing, pad, seat, mattress Pf, clothing, shaft and structure that can be placed close to living tissue and cells. ===== 48 200824744 and foot products TPPO/PUS213-001 69. If applying for a reversal, the connection method includes at least;; = electromagnetic treatment of animals and humans, and direct connection 1 -: wire, wireless signal transmission and reception 43 type of money in which the form is set to be programmable. The method is set in the __ county mosquitoes __ hand to the pulse magnetic field 1 Lu Shu 0 72 · as described in the scope of claim 43 for the animal and human set /, the waveform configuration mode in a random time Mark. The electromagnetic treatment of the class carries at least one pulsed magnetic field signal 74 as described in the scope of patent application 帛 73. The electromagnetic treatment device for animals and humans 49 200824744 TPPO/PUS213-001 as described in claim 43 Use, which contains the needle and the herbal agent - the way of transmission. Magnetic therapy equipment The electromagnetic treatment equipment for animals and humans mentioned in Item 43 is more suitable for the transfer of the standard to the transfer method. 7?? The scope of the scope of the 76th electromagnetic therapy treatment for animals and humans I ^ medical treatment includes at least the following treatment: neovascularization, blood, birth, heart and benign immunity Reaction, and treatment of exudation. The electromagnetic treatment device for animals and humans described in Item 43 of the patent "This wave configuration is integrated with the placement device. One of the magnetic therapy devices can be discarded. 79. The invention is for use in animals and humans, wherein the device is at least portable, implantable, and seeded. 80. The electromagnetic treatment device for animals and humans according to claim 43 of the patent application, The method further includes a plurality of at least one combination device for simultaneously generating at least one electromagnetic signal from at least one configured 50 200824744 TPPO/PUS213-001 waveform. For example, as described in claim 8 For animal and human-electromagnetic therapy devices, wherein the waveform of at least one of the configurations comprises at least one of: at least one waveform of the same configuration, and at least one of the different configurations of the waveform. The invention relates to the animal and the human-electromagnetic therapeutic device, wherein the method further comprises at least one of a plurality of combined devices for configuring the waveform by at least one configuration. And continuously generating at least one electromagnetic signal. 83. The electromagnetic therapy device of the animal and human being as described in claim 82, wherein at least one of the configurations of the wave is full of at least one of the following The waveform of at least one configuration, and the waveform of at least one of the configurations. • 84· * Patent application of the 43rd item of the animal and human electromagnetic treatment equipment • At least one of a combination of a device for multiplexing at least one electromagnetic signal from a waveform of at least one configuration. 85. An electromagnetic type for animals and humans as described in claim 84 The treatment device, wherein the waveform of the configuration of at least one of the at least one of the following: the waveform of the same at least one configuration, and the waveform of the different at least one configuration. 51 200824744 TPPO/PUS213-001 86. The vine animal and human _ electromagnetic treatment device according to item 43, wherein 彳§ is inductively coupled to the target path structure. 87. The vine animal and human electromagnetic treatment device, wherein the signal is capacitively coupled to the target path structure. ^ 88. The electromagnetic treatment device for animals and humans as described in claim 43 Wherein the signal is inductively coupled to the target path structure to prevent loss and degradation of cells and tissues. 89. The electromagnetic therapeutic device of the animal and human body described in claim 43 of the patent application, wherein the signal is capacitively Incorporating the target path structure to prevent loss and degradation of cells and tissues. The electromagnetic therapy device for animals and humans as described in claim 43 wherein the signal is inductively coupled to the target Path structure to enhance cell viability. 91. An electromagnetic therapeutic device for animals and humans as described in claim 43 wherein the signal is capacitively coupled to the target pathway structure to enhance cellular activity. </ RTI> </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> </ RTI> <RTIgt; 93. An electromagnetic therapeutic device for animals and humans as described in claim 43 wherein the signal is capacitively coupled to the target pathway structure to increase the number of cells. 94. For use in animal and human-electromagnetic treatment devices as described in claim 43 wherein the signal is inductively coupled to the target structure to prevent neuronal decay. 95. If the application __ Item 43 (4) in the animal and human _ electromagnetic treatment device, where the domain is capacitively combined _ target road 9J ·, the middle domain is domain-type combination 〇, /, medium and compact capacitors . The decline of the Yuan Dynasty: K-Synthesis 4 to the fine _, the adrenal gland 53 200824744 TPPO/PUS213-001 The electromagnetic treatment device for animals and humans described in the 43rd patent application. ______ Retreat. 100• As described in Section 43 of the patent application, 罟甘+K is used in the electromagnetic therapy device for animals and humans, and the medium signal is inductively coupled to the target. The posterior sacral structure to increase the adrenal neurons 101. As described in claim 43, wherein the signal is capacitively coupled to the _2 object and the number of human electromagnetic therapeutic devices. V invasive structure to increase adrenal neurons 102. As claimed in the scope of the 43rd item, where the waveform configuration is programmable, the object and the person_electromagnetic treatment device 54
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