TW200817057A - Oxygen producing device for woundcare - Google Patents

Abstract

A device is disclosed for the application of oxygen to promote wound healing and tissue repair. The device includes a portable oxygen generating device for delivering oxygen to the wound site. The oxygen generating device generates high purity oxygen through electrochemical means and includes a cathode, an anode, and a phosphoric acid treated ion conducting membrane. The oxygen generating device may be driven by a power source which supplies current to the anode and cathode. Oxygen in the ambient air is reduced to water and/or peroxide in neutral or ionic forms. One or more of these species diffuse through the ion conducting membrane and is oxidized at the other electrode to produce high purity oxygen.

Description

200817057 IX. Description of the invention: [Technical field to which the invention pertains] The present invention relates to promoting skin wound healing and tissue repair. More specifically, the present invention relates to the application of oxygen to an oxygen production device including an ion-conducting membrane to promote healing of a skin wound. [Prior Art]

It is known that providing an oxygen supply to a skin surface or a wound that penetrates the skin (e.g., ulcers, abrasions, cuts, sores, etc.) can promote wound healing. Oxygen therapy is used to induce the growth of new skin tissue to seal and heal the ischemic wound. Local oxygen therapy requires direct administration of oxygen to open wounds. Oxygen dissolves in the tissue fluid and increases the oxygen content of the intercellular fluid. Trauma and diseases that can be treated with local oxygen, including osteomyelitis, tendon and cartilage repair, sprains, fractures, burns and burns, necrotizing fasciitis, dysplasia, refractory ulcers, diabetic foot ulcers and acne Cancer (acne) and wounds, abrasions, and surgically induced wounds or incisions. There are several suggested ways to provide this oxygen supply or to adjust the oxygen concentration around the wound, depending on the benefits of the oxygen therapy described. Prior art teaches that local co-pressurization cannot be applied by placing a person's entire diseased limb in a sealed chamber with controlled: force: automatic oxygen regulation control features. These I air chambers are not only expensive and difficult to sterilize, but also because the chamber must be hooked to the external oxygen tank, which is also cumbersome, which limits the patient's movement: and 'because the entire limb is placed indoors or in the bag, it is large The area of the skin may not be the same as the tomb of the I. One, bring the blood potential (four) flat oxygen. This high level of oxygen can be a risk of poisoning and tissue damage. This system is illustrated in U.S. Patent No. 4,328,799, to which the reclining patient is connected to a gas chamber attached to an oxygen source.

U.S. Patent Nos. 5,578,022 and 5,788,682 illustrate systems in which the oxygen production device incorporates a patch or bandage placed directly over the wound. Both of these patents illustrate devices in which oxygen is produced in the form of electricity. These electrochemical devices use a membrane electrode assembly incorporating a proton exchange membrane. Proton exchange membranes are required to maintain their low ionic resistance. However, water has a relatively high vapor pressure and will evaporate. As the water in the membrane evaporates, the membrane loses its ability to conduct ions efficiently. Attempts to maintain membrane hydration by adding water from the outside can complicate the design of the actual device. For example, including a source of water that keeps the membrane moist can make the device cumbersome and reduce one of the main benefits of the device. Moreover, water provides a potential breeding ground for microorganisms. This is extremely undesirable for an oxygen generating device that is usually placed on or adjacent to a wound susceptible to microbial infection. The parent patent application can overcome some of these shortcomings. However, there is still a need for a more convenient and inexpensive oxygen manufacturing device for wound care. SUMMARY OF THE INVENTION In the aspect of the invention, a device for supplying oxygen to a patient for treating a wound or a condition includes: a wound dressing on a wound or injury treated with oxygen; b) portable away from the wound dressing An oxygen generating device for supplying oxygen to skin scars, the device comprising: - a shell having a bottom portion matching the top of the bottom, wherein the top crane and the ancient gate have an outlet; and one for electricity > Ft produces a gas film electrode assembly, Li Mingyi JJ9, ^Gang private depolarization, a cathode and a member of the 122816.doc 200817057 conductive film; and a circuit board with associated swimming + 1 ~ power; wherein the membrane electrode The assembly is mounted on the top of the housing, thereby forming a closed cavity between the anode and the top of the housing, and the outlet is fluidly connected to the cavity by the #兮山t ^; and C) the fluid connection outlet Catheter with wound dressing.

In a second secret, a portable oxygen generating device for supplying oxygen to a skin wound is provided, the device comprising: - a body having a top and a bottom with a top portion - wherein the top has a - sigma; - for electrochemically generating oxygen a membrane electrode assembly, comprising: an anode, a cathode, and an ion conducting membrane; and - a circuit board having an associated power source; wherein the membrane electrode assembly is mounted on the top of the body" thereby forming an anode therebetween A closed cavity with the top of the housing such that the outlet is in fluid connection with the cavity. [Embodiment] The present invention relates to an oxygen manufacturing apparatus for wound care applications. The present invention simplifies the portable self-containment for topical application of oxygen to promote wound healing, as disclosed in U.S. Patent Nos. 5,57,22 and 5,788, the entire disclosure of which patent application Serial No. 10/52,. Construction and operation of the device. The issues involved include: 膜 The film made from currently available ion-conducting polymers becomes dry when exposed to environmental conditions. When dry, the films exhibit high ionic resistance resulting in device failure. For application to wound healing, the oxygen generating device is taped and exposed to impurities that can contaminate the catalyst for oxygen reduction and/or & generation. The apparatus of the present invention operates on the principle that they are similar to those explained in our τ 。 。 1228l6.doc 200817057 (U.S. Patent No. 5,578, filed on Jun The patent has been named by 〇genix

EpiFL〇SD is being commercialized, and by? 1:) Eight approved for the treatment of certain types of wounds. More specifically, it utilizes the reduction of oxygen on a high zone gas permeable cathode to produce product water and oxidizes water on a high zone gas permeable anode to produce pure oxygen.

The two electrodes are attached to the opposite side of a thin polymer electrolyte membrane (pEM) (e.g., Nafi〇n8) in much the same manner as in a PEM fuel cell. The % pole side and the cathode side of the battery are separated from each other. Since the air permeability of the assembly is very low, the operation of the apparatus increases the oxygen content toward the anode side while consuming the oxygen content toward the cathode side. DETAILED DESCRIPTION OF THE INVENTION Referring now to the drawings, which are for the purpose of illustrating a preferred embodiment Referring to Figures 1 and 2, there is shown a knife map of an oxygen manufacturing apparatus according to an aspect of the present invention. The device includes a housing having a top portion 12 and a bottom portion 14. The top 4 and bottom can be designed to be detachable. This can be accomplished using a variety of accessory options, such as a simple clip structure 16. A circuit or control board 18 is attached to the interior of the housing. The board contains electrical components for controlling electrical energy from a power source (e.g., battery pack 2) and for operating and controlling the oxygen manufacturing apparatus. Oxygen is produced in the apparatus by an electrochemical cell or membrane electrode assembly 22, as shown in Figure 4. The electrochemical cell or membrane electrode assembly 22 includes a porous cathode, an ion conducting membrane, and a porous anode. The electrochemical cell is attached to the top 12 of the housing using any conventional means. When attached, the anode of the battery 22 is preferably hermetically sealed to the top of the housing to prevent air or other gases from being transferred from the interior of the housing to the anode side of the battery (Fig. 2). When attached to the top portion 12 of the housing, a small or upper void 32 is formed between the anode and the inner surface of the top portion 12 of the housing. The cavity on the anode side of the battery is in fluid connection with an outlet 3〇 located in the top 12 of the housing. The fluid connection between the cavity and the outlet can be made in the top 12 of the housing. The closed passage 32 is achieved. The outlet 30 can be equipped with a Luer or Luer-Loc type connection. _ In operation, the cathode is exposed to the atmosphere, for example, through a venting aperture (not shown) located on the bottom 14 of the housing. As detailed above, the anode is in fluid communication with the outlet 3, which itself may be in fluid communication with the skin wound by the use of a catheter or cannula (described in more detail below). The cavity is filled with gaseous oxygen produced on the anode. Oxygen flows from the cavity to the outlet where it can be delivered to the wound site by a cannula. Referring to Figure 4, an oxygen k-device suitable for use in any of the above embodiments can be generally described as including a membrane electrode assembly (MEA) or electrochemical cell for electrochemically concentrating oxygen gas from air. 100 (marked 22 in the above figure j). The ion-conducting membrane 1〇2 is positioned between the two electrodes (1〇4, 1〇6), and the electrodes (104, 1〇6) are in turn with a power source 1〇8 (for example, an electric 'cell) that can pass current through the electrodes. connection. • As shown in Fig. 4, oxygen in the ambient air is reduced to water in the interface region 110 between the cathode 1〇4 and the membrane 1〇2 which maintains the reduction potential according to the proton supplied from the membrane according to the following reaction. The product water migrates (or diffuses) through the membrane 1〇2 to the anode 106 which maintains the anode potential, and the drain reoxidizes the water to oxygen while releasing protons in the interfacial region 112 between the anode and the membrane. Proton movement through 122816.doc 200817057 The membrane passes to the cathode 104, allowing oxygen from the air to continue to be reduced. The atmosphere t nitrogen and carbon dioxide are electrochemically oxidized under the reaction conditions required for oxygen reduction and the mouth is effectively repelled on the cathode. Only the reduced product oxygen can move through the membrane, producing nearly 100% pure oxygen on the anode. The oxygen then passes directly to the tubing for delivery to the wound site. Therefore, in the present invention, the following reaction mechanism can be used to produce oxygen: at the cathode ··〇2·μη++4θ^2Η2〇 at the anode: 2Η2Ο — (3⁄4 + 4H+ + 4e- net reaction is to consume gaseous state on the cathode side of the membrane Oxygen (from ambient air) and an increase in oxygen concentration on the anode side. Preferably, an adhesive tape (not shown) for attaching the housing to the patient's skin is attached to the bottom side periphery of the bottom housing 14. The oxygen pressure within the chamber will vary depending on the size of the cavity and the size of the outlet and the cannula and the rate of oxygen production. However, preferably the pressure is not high enough to cause vasoconstriction. The bandage itself may have multiple layers that comfort the patient and promote healing. These include, but are not limited to, several layers of cotton gauze, polyethylene oxide-water polymer, and one or more layers containing softeners and other musicals including antibiotics, preservatives, growth factors, and tongue cells. Preferably, the bandage is closed on all sides to maintain an oxygen enriched atmosphere. As described above, the device preferably uses one or more batteries as a power source. The circuit board can have an electronic timing device that can be set For the rule Oxygen delivery over a period of time, such as 7 or 15 days of oxygen therapy. The unit shown in Figure i can be powered by a variety of primary or secondary battery power sources, including alkaline cerium oxide, zinc-air, lithium sulfoxide , lithium epoxide short, lithium ion, 122816.doc -11· 200817057 metal nitride, and the like. Referring to FIG. 3', a sputum manufacturing apparatus and a patch assembly 8G according to a second embodiment of the present invention are roughly shown, and Containing a dressing or a belt to be placed on the wound, as described above, for the oxygen supply device for supplying oxygen to the wound 84,, and!! The oxygen-making device is fluidly connected to the bandage 82 and the lower wound, such as a flexible conduit. Or sleeve 86. The flexible conduit may comprise a -L_ type or a similar type of connection. The conduit is preferably manufactured from a polymer suitable for hospital applications. Suitable materials for the pipeline include, but are not limited to, polysulfide Polyethylene, polypropylene, polyurethane vinegar and a variety of other thermoplastics. By electrochemical reaction, oxygen is produced in the oxygen production unit 84. The oxygen is then transported through the flexible conduit 86 to the wound covered by the material. For wounds and to cover wound dressings, the tubing can be used to access the dressing in a variety of ways. For example, the end of the cannula can be placed directly over the wound and completely under the dressing, thereby allowing the normal bandage to "enrich oxygen." The invention allows oxygen to be delivered to the wound in a variety of ways. That is, the present invention allows for the delivery of oxygen subdermally, transdermally, and/or locally to achieve: a treatment. In vivo applications, the cannula end can be implanted in a desired treatment. The position of the cannula = the implanted end can be perforated with a plurality of openings or made of a material that allows oxygen to diffuse into the ischemic tissue or blood vessel through the wall: and, at the end of the tube, can be attached to the syringe Promotes the introduction of oxygen under the dermis. It can promote local gold tube formation or ischemia-reperfusion and increase the location specificity of metabolism. = Gas delivery is beneficial for orthopedics and organ repair and tissue, bone, tendon, and cartilage regeneration. For improved radiation oncology should be m-woven and tumor 1228l6.doc •12· 200817057 Local oxygenation can benefit from the device. Thus, the device can be considered a universal source of oxygen supply because it can be used with a variety of commercially available bandages or dressings. Can be used with the present invention: other types of dressings include fully sealed film dressings, hydrocolloids #, bath dressings, antimicrobial dressings, biosynthetic dressings, collagen, dressings, foam dressings, combination dressings, hydrogel dressings , preheating dressings: and transparent dressings. • In other applications, the device can be used to treat venous leg ulcers, where the patient must wear a braided four-part compression dressing to control swelling and edema. The distal oxygen manufacturing device 84 and conduit 86 can be placed on top of the compressed dressing whereby the device can be prevented from being pressed against the leg while the prior art device must be pressed against the leg. The official track 86 can be incorporated between the four separate layers of the compressed dressing to fit the leg just without excessively pressing the oxygen generating device 84, which consists of an oxygen generator, battery and hardware, against the fragile skin surrounding the wound. Positioning the device on top of the compressed dressing provides a further benefit of ensuring unrestricted delivery of oxygen from the atmosphere to the wound without relying on the diffusion of the atmosphere through the dressing. The distal device can be positioned anywhere the patient is comfortable and comfortable. For example, a patient with a wound on the sole of the foot can wear a thin end band, add a soft tube and • attach the device away from the wound to the ankle or leg. This allows the patient to wear the shoe while receiving oxygen therapy without the size and comfort limitations of prior art. For patients whose wounds are located on the humerus, ankle, back or other pressure points, the device can be placed away from the wound and pressure points to make the patient most comfortable. Then a relatively soft tube can be pointed at the wound site. 122816.doc -13- 200817057 The microbes at the wound site can contaminate the bandage placed on it or the use of a device with a disposable, g(4) device can prevent microbial production from reaching the device. The channel acts as a microbial barrier to the device. The pipe is supplied to the positive air pressure of the injury σ and separated by a sufficient length to prevent backflow contamination of the device. Optionally, the device can be in the pipe or at either end thereof. - The same application of a microbial biofilm interruption mechanism: further protection. The dry membrane) is known as the ion-conducting material, and the (tetra)-ion ion-conducting type. Suitable membranes include various types including poly (four gases). Ethylene) a backbone and a regularly spaced all-polyether side chain perfluorinated ionomerized membrane terminated by a strongly hydrophilic acidic group. Preferred membranes suitable for use in the present invention include those contained in the side chain. A sulfonic acid terminating group and is commercially available from EI Dup〇nt, Inc. Nafi〇n8 is a full-polymer containing a ratio of a repeating acid group or a (tetra) ionic functional group. See below as 'a sulfonate or carboxyl functional group, and a metal cation in a neutral form or an η+ in an acidic form. Other suitable membranes include partially fluorinated membrane materials and their hydrocarbon-based (tetra) complexes. Primary key., --(CTC F^ Ο

122816.doc -14- 200817057 The electrodes used in the membrane electrode assembly may be in the form of a screen or thin coating on the opposite surface of the membrane. It can be made of any material that is electrically conductive and can catalytically reduce gaseous oxygen to water and can catalyze oxidation of the product water to release oxygen. Suitable electrode materials include, but are not limited to, in the form of pure particulates or as the supported catalyst beta, ruthenium, osmium, iridium, and alloys and oxides thereof. In one embodiment of the invention, the Nafion 8 film is treated or absorbed with 85-100% phosphoric acid. In Nafion®, water typically provides a network of hydrogen bonds _ and allows protons to pass quickly through the polymer (and therefore has high ionic conductivity). However, when placed under ambient conditions, the water of Nafion 8 is lost to the environment (due to the relatively high vapor pressure of water), which causes it to lose ion conductivity. Phosphoric acid also provides a network of hydrogen bonds similar to water, but unlike water, it has a very low vapor pressure - at room temperature, the vapor pressure of phosphoric acid is low enough to be considered zero. It also has a degree of hygroscopicity so it can absorb water from the atmosphere. The combination of these properties makes it possible to replace most of the water in Nafion® with an acid under suitable conditions. • A method of fabricating a membrane electrode assembly that achieves the above objectives involves adhering a Pt/C electrode and a platinum black electrode to either side of a Nafion® 117 (or similar) membrane. The electrical connection from the electrode to the voltage source can typically be provided by a conductive end plate typically made of thick graphite or a metallic material. In order to reduce the weight and improve the mobility of the device, a thin conductive (eg, rear ear) wire having conductivity and electrochemical inertness can be placed between the film and the electrode during the bonding process, thereby electrically connecting the film electrode. The overall part of the assembly. Examples of such wires include: gold, platinum, electroplated or deposited gold or platinum buttons, and the like. In addition, a catalyst can be used to improve the electrochemical generation of oxygen in the above reaction. 122816.doc • 15 - 200817057 Adding a catalyst to the electrode or two electrodes helps to overcome the kinetic anti-pool, and has | Pt-Ru, Pt_Ir, or the like, can be used to coat electrodes. The use of such toxic resistant catalysts prevents impurities from the binder and other components of the device from degrading the catalytic activity and deactivating the material. Examples of suitable non-limiting anode catalysts include

Pt > Ir, Pt-JSn, fengan one / one eight two 70, and five. Suitable non-limiting cathodic catalyst

Examples include Pt.Ru/c, Pt_Sn, pt, pt c, and ternary compositions thereof. The preferred catalyst is pt_Ir. The circuit board or controller can include a switch and a current monitoring port. The amount of oxygen produced by the device can be varied by varying the voltage applied across the electrodes. Usually 'the device can produce about! Up to about 5 ml of oxygen per hour, more preferably from about 1 to about 1 ml per hour. The invention has been described with reference to a number of preferred embodiments. Obviously, others will make modifications and variations after reading and understanding this specification. It is intended that the present invention include all such modifications and modifications that are within the scope of the appended claims. BRIEF DESCRIPTION OF THE DRAWINGS The present invention may be embodied in a form of a part of the components and the arrangement of the components, and a preferred embodiment thereof will be described and illustrated in detail in the specification and drawings which form a part of the invention. Figure 1 is a top plan view of a 3/4 exploded view of an oxygen manufacturing apparatus. Figure 2 is a top bottom view of the oxygen (IV) device according to the embodiment. Figure 3 is a side cross-sectional view of a tube-provided oxygen generating patch deployed to a patient in accordance with an embodiment of the present invention. 1228l6.doc • 16 - 200817057 Figure 4 is a schematic view of a membrane electrode assembly (electrochemical cell) used in the present invention. [Main component symbol description] 12 Top 14 Bottom 16 Clip structure 18 Circuit board or control board 20 Battery 22 Electrochemical cell or membrane electrode assembly 30 Outlet 32 Upper void 80 Patch assembly 82 Dressing or bandage 84 Oxygen manufacturing device 86 Catheter or cannula 100 Electrode assembly or electrochemical cell 102 Ion-conducting membrane 104 Cathode 106 Anode 108 Power supply 110 Cathode-to-membrane interface region 112 anode-to-membrane interface region 122816.doc -17-

Claims (1)

200817057 X. Patent Application Range: 1. A device for supplying oxygen to a patient to treat a wound or condition, comprising: a) a wound dressing suitable for receiving wounds or injuries that can be treated with oxygen; Wound dressing A portable oxygen generating device for supplying oxygen to a wound, the device comprising: a housing having a top and a bottom, wherein the top has a σ; a membrane electrode assembly for electrochemically generating oxygen, Including a pole-cathode and an ion-conducting membrane; and a circuit board having an associated power source; wherein the membrane electrode assembly is mounted on the top of the housing, thereby forming a hermetic seal between the anode and the top of the housing a cavity such that the outlet is in fluid connection with the cavity; and a conduit for fluidly connecting the outlet to the wound dressing. Item 1. The device for supplying oxygen, wherein the catheter is a flexible braided dressing for treating a venous ulcer as claimed in claim 1; Between the layers. The device wherein the wound dressing is a four-part compression dressing. The apparatus, wherein the pipe is incorporated therein, wherein the oxygen is further subcutaneously conveyed by a device for supplying oxygen, such as that of the present invention. 6_The device for supplying oxygen as claimed in the claim 122816.doc 200817057 The syringe at the end of the pipe is fluidly connected for the delivery of oxygen under the dermis. 7. The apparatus for supplying oxygen according to claim 1, which further comprises a semipermeable membrane for preventing microorganisms from flowing back into the helium gas producing apparatus. 8. The apparatus for supplying oxygen according to claim 1, wherein the oxygen is generated by one, two or four electronic processes. 9. The apparatus for supplying oxygen, wherein the ion-conducting membrane is a perfluorinated ion-polymerized membrane. 10. A device for supplying oxygen as claimed, wherein the power source is a battery that applies a current across the cathode and anode. 11. A device for supplying oxygen as claimed, further comprising a catalyst present in at least one of the anode and the cathode. 12. The apparatus of claim 11, wherein the catalyst comprises Pt_ Ir° 13. The apparatus for supplying oxygen according to claim 1 wherein the apparatus is at a standard temperature Produce about 1 to (four) milliliters of oxygen per hour with a pressure of 1 Torr. 14. The apparatus of claim 1 for supplying an oxygen rain π device, wherein the device generates oxygen of different durations based on the characteristics of the power source. Wherein the pipe perforation has a device for supplying oxygen as in claim 2, the plurality of openings for allowing in vivo treatment. Wherein the oxygen generating device I6 is installed on the patient as claimed in claim 1 for supplying oxygen. 17. If the request is for the port. Further, wherein the outlet is a Luer 122816.doc 200817057 18. The apparatus for supplying oxygen as claimed in (1), the step further comprising connecting the outlet to the closed passage of the cavity. 19. A portable oxygen generating device for supplying oxygen to a wound π, the stabilizing comprising: a garment having a top and bottom housing, wherein the top has a membrane electrode for electrochemically generating oxygen And comprising: an anode, a cathode and an ion conducting membrane; and a circuit board having an associated power source; wherein the membrane electrode assembly is mounted on the top of the housing, thereby the anode and the housing A closed cavity is formed between the tops such that the outlet is in fluid connection with the cavity. 122816.doc