TW200800095A - Devices and methods for treatment of skin conditions - Google Patents

Abstract

Devices and methods for the treatment of skin conditions and lesions are disclosed herein. One aspect of the invention is a compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices described herein employ the application of heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 70 DEG C to about 400 DEG C by the devices, are achieved in less than about l second, and maintained for less than about l second, In some embodiments, the skin surface is heated with heat pulses. Thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.

Description

200800095 IX. Invention Description: [Technology and Standards City of the Invention] Cross-reference, the case is US Patent Application No. 11/216,595, entitled "Skin Treatment * 5 Therapeutic Device", application date August 30, 2005 In the contiguous section, the case is hereby incorporated by reference. The case is filed in US Provisional Patent Application No. 60/634,904, entitled "Skin Treatment Device", application dated December 2004, 10 pp., and US Provisional Patent Application No. 60/653,740, entitled "Skin Rejuvenation Device", Application优先权The priority of February 16, 2005, and the second case is incorporated herein by reference. The present invention relates to devices and methods for treating skin conditions. BACKGROUND OF THE INVENTION Patients with acne account for more than 90% of all puberty, nearly 50% of all adult females, and 25% of all adults. A major cause of acne is caused by improper drainage of hair follicles by dead cells or dirt trapping oil and bacteria. The hair follicle opening has a diameter of from about 50 microns to about 1 inch. The opening of any other pores on the skin is substantially smaller. The special sweat gland opening has a diameter of about 30 microns. 20 There are many ways to treat acne. Benzoyl peroxide is a commonly used ingredient in the treatment of traditional Chinese medicine, and it is extremely effective for the treatment of mild non-inflammatory acne. Benzoyl peroxide is safe for children and adults and can be used in combination with other local or oral treatments. For patients with moderate acne to severe acne, the physician may prescribe a combination of topical treatment and oral antibiotics. 5 200800095 The most commonly used oral medications for the treatment of acne are tetracycline, minocycline, doxycycline (d〇XyCyclille), and erythromycin 〇, in addition to drugs. Including ultraviolet light irradiation, laser treatment v 5 or microdermabrasion. Most systems are bulky and require professional processing in most cases. U.S. Patent No. 6,635, No. 75 to Li et al. describes a heating device that can be used to treat acne. The device described herein uses a heater and a temperature sensing φ device to maintain a constant temperature surface applied to the skin. For long-term application (several minutes) to prevent burns, the maximum allowable temperature is about 62. Hey. Long-term treatment 10 ^ cost device for normal acne treatment is not practical. There is a need for short devices that can be used effectively and quickly to treat acne. The present invention satisfies this need to further provide related advantages. The method of rejuvenating the skin is from intense face plastic surgery and laser (such as using carbon dioxide laser) or chemical money to finish the surface of the skin, to 15 non-effective non-burning laser system, rf can skin rejuvenation Secret, micro-grinding • 纟, other money-making devices and various lotions and creams. Other methods include the application of ultraviolet light, infrared light and light radiation, laser processing, mechanical abrasion, or ultrasonic energy. Most systems are large systems and in most cases require professional handling. There is a need for a device that can effectively restore the skin to youth. 20 SUMMARY OF THE INVENTION An object of the present invention is to provide an apparatus and method for treating skin disorders and skin lesions such as acne, silky fine lines and cleansing the skin. Another object of the present invention is to provide a hand-held device that can safely feed the skin without causing burns. These and other objects are apparent to those skilled in the art based on the teachings herein. One aspect of the present invention provides a device for treating a skin condition comprising: a heating element adapted and assembled to contact the surface of the skin; and a control element adapted to be assembled for less than about 1 second. The time period heats the heating element to at least about the thief temperature, and the heating element is maintained at a temperature of at least about 70 ° C for less than a leap second time in response to a user input. In a number of embodiments, the controller is further adapted to stop heating of the heating element and to reheat the heating element without additional input from the user. The heating element and the 10 controller can be placed inside the housing, and the housing can be held in the palm of the user. Another aspect of the present invention provides a device for treating a skin condition, comprising a housing adapted to be assembled in a palm of a user, the housing comprising a heating that is adapted to be in contact with the surface of the skin. And a controller adapted to heat the heating element 15 to a temperature of at least about 7 ° C for a period of time of less than about 1 second to maintain the heating element φ at least in response to a user input. Approximately 7 (TC temperature experienced less than 1 second time; and a user interface suitable for assembly to provide user input by activation by the user. The controller is further adapted to stop heating of the heating element and to reheat the heating element without use Further input to the invention. In yet another aspect of the invention, there is provided a device for treating a skin condition comprising a heating element adapted to be placed in a surface facing away from the skin to be treated; Holding, the handle area supporting the heating element when placed against the surface of the skin; and suitable for heating the heating element to a temperature of at least about 67 ° C for less than about 0.1 seconds of heating In several implementations 7 200800095 H 4 heating element includes a wheel that is adapted to respond to the user, controlling the control of the heat that is difficult to produce. The control material is stepped to stop the port = the heating element and reheating the heating The component does not require additional wheeling by the user. ' ▲ ^ In this aspect of the sun, the heating element can be a resistive heater, such as a metal resistor. The heating element can be selected from nichrome, A metal of a group consisting of:, gold, copper, and/or steel. The heating element has a stomach liner, an insulating layer, and a high layer. The skin contact surface of the heated member has a surface area of about 1 square centimeter. In each of these aspects of the invention, the heating element is adapted to be heated to a temperature of from about 75 ° C to about HKTC, or from about HKTC to about 200 C, to less than about 〇 5 seconds. The total energy is limited to less than about 5 〇 joules per square centimeter. or meters or about 5 joules per square centimeter. The apparatus also includes a suitable combination to sense the temperature generated by the heating element and to control the temperature of the heating element. 15 S-degree sensing ϋ. The device also includes The heating element and/or the skin surface is cooled to a cooling element below about 6 GC. The device 4 also includes a light emitting diode. In several embodiments, the heating circuit is further adapted to heat the heating element to at least 67°. The C temperature is experienced for less than about 1 second, the heating element temperature is lowered by 2 Torr for about 5 seconds, and the heating element is again heated to at least 67 ° C for a time of less than about 0 J seconds. The user interface can be activated by the user to heat the heating element to about 250 in about i milliseconds. The peak temperature of the peak is attenuated to less than about 〇·5 seconds to about 1〇〇200800095. Another aspect of the invention provides a method of treating a skin condition comprising the steps of heating an individual's skin surface to a temperature of at least about 70 t for less than about 1 second in less than about 1 second. Several embodiments include the steps of stopping the heating step for about 10 milliseconds to about 5 seconds and then heating the skin surface 5 to at least about 70 ° C for less than about 1 second. The heating step and the reheating step can be repeated. Another aspect of the present invention provides a method of treating a skin condition by applying at least two heating pulses to an individual's skin surface to raise the surface of the skin to a temperature of at least about 7 ° C for less than about 1 second. Ten peak temperatures can be achieved with each pulse. Several embodiments include the step of providing a delay between heating pulses that allows the skin surface to reach temperatures below about 50C. The method also includes applying a topical substance to the skin surface before, during, and/or after application of the peak temperature. The skin condition treated by the joint may be acne, blemishes, cold sores and/or skin wrinkles. In several embodiments, the temperature can be maintained above about 7 〇t for less than about i seconds. Yet another aspect of the present invention provides a method of treating a skin condition comprising applying a heat source to a skin surface and heating the heat source to a peak above about 67 °C for less than about 0.1 second. Several embodiments include stopping the heating step for a period of from about 1 millisecond to about 5 hours, and then heating the skin surface to at least about 30 degrees. . Temperature 2〇 takes an extra step of less than about 1 second. The stop step and the reheating step can be repeated. In several embodiments, the heating element comprises a resistive heater and/or a thin metal resistor. The metal in the heating element can be a knuckle alloy, crane, inscription, gold, steel and/or steel. The thickness of the electrical resistance heater is preferably less than 200 microns and has a surface area of about 1 square centimeter. In some embodiments, the heating element comprises a backing layer that increases strength and heat conductivity; an insulating protective layer disposed directly on the skin; a highly conductive layer of improved temperature uniformity directly placed on the skin; and/or a combination The charging capacitor stores enough energy to heat one of the heating elements 5

10 15 20 circuit. The controller includes a control circuit and a temperature sensor, wherein the control circuit monitors the temperature sensor to prevent heating of the heating element to a temperature that may burn human skin. In several embodiments, the device further includes a cooling element. Typically the cooling element cools the skin and/or the heating element and is preferably cooled between two heating pulses. In addition, the cooling element ensures that the heating element is not heated again until the heating element and/or skin has reached a temperature of about or below. In some embodiments, the person in the package further includes a temperature sensor such as a thermocouple, and/or a battery powered light emitting body attached to the housing to provide illumination. Another aspect of the present invention is a device for transporting a controlled amount of <RTI ID=0.0>>><>></RTI> Preferably, the step comprises a thin insulating layer placed between the resistive heating element and the target to be locked. The device preferably rapidly heats the skin to above 50 t π. Another embodiment is a device for heating the skin, which comprises a dish and a thermoelectric cooler for contacting the skin surface, and the conveying control can be controlled. W This is a circuit that activates and activates one of the circuits. In the case of light and flat and 1 soil-poor example, the device further comprises a component which is suitable for assembling to reverse the polarity of the thermal cooler, so after heating for a period of time, the electric heating/suppressing electricity... The hot plate of the device is turned into a cold plate, and the surface of the skin is allowed to cool for 1 second. In the embodiment 10 200800095, the device further comprises space and time heating of the skin surface and the device can heat the skin surface. To the time of the week or above, preferably or below. In the implementation of the rape, this article describes;;; about 5 seconds about 20 〇t peak temperature, this peak, w clothing can be heated to I has maintained less than about 5 seconds, preferably less than about 10 15 20 when it is iced, and the present invention is a device for treating skin diseases. ???, _, time force, to _ , the dish maintains the peak temperature for less than 1 second, and contacts the surface of the skin:: the response is controlled by the input of the user.

One of the Vi controllers. The device further includes a heating element and a housing that controls $. The bribe is suitable for holding in the hands of the maker. In another implementation, the present invention is a device for treating a skin condition comprising: a housing adapted to be held in a user's hand, the housing comprising a suitable combination for heating to at least about 1 second to at least A temperature of about 7 (the peak temperature of rc, maintaining a low peak temperature between the materials, and contacting the surface of the skin), and a controller suitable for controlling the heat generated by the heating element in response to input from the user And a power source; and a user interface adapted to be controlled by the user to control the heating element. Yet another embodiment of the present invention is a device for treating a skin condition, comprising a suitable combination for placing the back to be accepted a heating element of the treated skin surface; adapted to be held by a user and supporting a handle area of the heating element when placed against the skin surface; and suitable for assembly to heat the heating element to at least about 67° The peak temperature of C experiences less than about one second of time. 11 200800095 Heating circuit. The apparatus described herein can include a temperature sensor that is adapted to be assembled to sense the heat generated by the heating element. The heat 'controls the heat generated by the heating element. It also includes a set of cooling elements that are adapted to cool the heating elements 5 and 7 or the skin surface to a temperature below about 60 ° C. In a preferred embodiment The apparatus includes a heating circuit adapted to heat the heating element to a temperature of at least 67 ° C for less than about 0.1 seconds, reducing the temperature of the heating element for about 0.5 seconds, and again heating the heating element to at least 67° The C temperature experiences less than about 〇1 sec. In another preferred embodiment, when the device is activated by 10, the heating element is heated to a peak temperature of about 1% in about 1 millisecond, the peak temperature Decay to about 1 Torr in less than about 0.5 seconds. (: Another aspect of the invention is a method of treating skin disorders such as acne, blemishes, and skin wrinkles using the device of the present invention. In an embodiment, the device is a combination of a topical agent for treating a skin condition. The topical agent 15 can be used by a user or can be administered using the device described herein. The invention can also be combined with a acne treatment cream and a gel. To further accelerate For example, a cream or a gelatin containing benzoyl peroxide may be administered before or after administration of the device. A preferred method of the invention is a method of treating a skin condition comprising the skin surface of an individual Heating to at least about 7 Torr: peak 20 temperature, wherein the peak temperature can be reached within less than about 1 second, and the heating time is less than about 1 second. Another preferred method is a treatment for skin disorders. The method comprises applying at least two heating pulses on the surface of the skin of the individual to raise the surface of the skin to at least about 7 (the peak temperature of TC, which can be achieved by each pulse less than about ice time. There may be a delay between the heating pulses, To allow the skin surface to reach a temperature below 12 200800095 below about 5 ° C. Preferably, the peak temperature can be maintained for less than about 1 second in the method. A preferred method is a method of treating a skin condition comprising applying a heat source to The skin surface, as well as heating the heat source to a temperature above about, experiences less than about 0.1 second. The method further comprises the step of stopping the heating for a period of time of about 5 seconds, and heating the source of heat to a temperature of greater than about 67 ° C for less than about 0.1 seconds. Other objects and advantages of the present invention will become more apparent from the following description and the accompanying drawings. 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 BRIEF DESCRIPTION OF THE DRAWINGS The novel features of the present invention are particularly set forth in the appended claims. The details and advantages of the present invention will become more apparent from the detailed description of the embodiments of the invention. The acne treatment device uses a thin film resistor to deliver energy into the interior of the skin. 20 _ 2 shows a cross-sectional view along an embodiment of the heating element. The heating element includes a backing layer. Figure 3 shows a cross-sectional view taken along another embodiment of the heating element. Figure 4 shows a section taken along another embodiment of the heating element. 13 200800095 Figure 5 shows another embodiment of a hand-held acne treatment device incorporating a shield. Figure 6 shows a possible grid 5 of applying a pulse to a thin film resistor. Figure 7 shows a block diagram of a device that uses a microprocessor to allow a user to apply different sequences of heating pulses. Figure 8 shows the temperature history of a single heating pulse at different tissue depths from the surface. 10 Figure 9 shows the temperature history of the two different heating pulses (0 sec and 2.0 sec) with the same total energy as in Figure 8, at different tissue depths from the surface. Figure 10 shows how the device is used to treat facial dark spots. Figure 11 shows the healing effect of acne after using heat treatment. [Embodiment 3] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS While the preferred embodiment of the invention has been shown and described, it will be apparent A person skilled in the art can make various changes, changes, and substitutions without departing from the invention. It is to be understood that the invention may be practiced with the various embodiments described herein. The scope of the invention is intended to be defined by the scope of the invention, which is intended to cover the scope of the invention. The present invention is a lightweight, short hand-held device that can be used by adolescents and adult women suffering from skin disorders and skin lesions such as acne, dark skin or fine wrinkles. In one embodiment, the present invention comprises a hand held 14 200800095 type device having a switch device such as a 0n/0ff switch and an activatable device when placed in a locked target position. In one embodiment, activation of the device permits application of a thermal pulse to the affected area of the skin. The battery inside the unit can be powered to the board to drive short pulse current through the thin film resistor. In one embodiment, the 5 thin film resistor is heated to about 300 ° C in less than 1 second. Heat transfer transfers heat to the skin, causing a biological response that accelerates the removal of acne. The total delivered energy is low enough to prevent burns, and the total delivered energy is typically less than about 5 〇 joules of 7 square centimeters, and for most applications is less than about 5 joules per square centimeter. Preferably, the delivery to the skin is less than about 6 FJ/cm, less than about 55 J/min, less than about 5 FJ/cm, and less than about 45 J/cm. Less than about 40 joules per square centimeter, less than about 35 joules per square centimeter, less than about 30 joules per square centimeter, less than about 25 joules per square centimeter, less than about 20 joules per square centimeter, less than about 15 joules. /cm 2 , less than about 1 〇 joule / flat money meter, or low (four) 5 joule / flat money meter. The I5 energy to the skin can range from about 5 joules per square centimeter to about 1 mole joule per square centimeter, from about 8 ears per square centimeter to about 15 joules per square centimeter, from about 15 joules per square centimeter to about 20 joules per square centimeter. Meter, about ear/pay (four) to about 25 joules/cm 2 , about 25 joules/cm 2 to about 3 〇 joules per square centimeter, about 3 〇 joules per square centimeter to about 35 joules per square centimeter, about 35 joules / Square centimeter (four) 40 joules / square centimeter, about 4 〇 joules / square centimeter to about 45 joules / square centimeter, about 45 joules / square centimeter silk bay, ear / square centimeter, or (d) 隹 ear flat square centimeter to about _, ear / square centimeter. In another embodiment, the ultra-bright LED of the present invention is operative with the device for illumination in the blue or red spectral range, and is improved. 15 200800095 The device described herein utilizes light energy, thermal energy, or a combination of both for selective surface heating, allowing the user to achieve temporary enlargement of the pores to clean the pores of the skin and to eliminate undesired filling of the pores. Debris and undesired substances, thus reducing the size of improper pores and promoting skin health 5 and skin appearance. The method is also contemplated to encompass the deposition of thermal energy and/or light energy into the skin to allow selective damage to the upper layers of the skin and to allow for the creation of new, more elastic collagen. The devices described herein are also designed to allow for more effective treatment of the skin with potentially lower dosages of rejuvenating agents. It is not intended to limit the use of the machine. It is believed that controlled damage to the epidermis and the upper layer of the dermis will lead to the creation of new collagen, which can produce a double effect through the combination of photothermal heating and absorption enhancement. The present invention includes a lightweight, short hand-held device that can be safely used by adolescents and adults who desire to improve the texture and appearance of the skin structure while reducing the occurrence of acne, dark spots or small lines. In one embodiment, the present invention is a hand-held device that can be safely used to heat a skin layer controlled by 15 to allow the skin to rejuvenate and regenerate collagen without causing damage to adjacent tissues while promoting Skin health and appearance. Thin film resistors can be heated with enough energy to rejuvenate the skin and induce a biological response that improves the appearance of the skin. In several embodiments, the energy delivery time is less than about 0.7 seconds. Heat transfer can transfer heat to the skin, causing a biological response that promotes the appearance of the skin. The total heat transfer can be low to prevent burns, and the thermal energy is less than about 50 joules per square centimeter, and for most uses less than about 10 joules per square centimeter. In another embodiment, the thin film resistor of the present invention is replaced by a light absorbing layer heated by a flash lamp inside the device. The flash can produce broadband light (white light) by short discharge. Depending on the desired final temperature of the light absorbing layer, one or more flash lamps can be illuminated simultaneously to combine their light under a single reflector to introduce the light guide into the target skin. In addition, the lamps can be illuminated sequentially to achieve a wider and longer energy pulse time. Again, heat transfer transfers heat to the skin, causing enlarged pores, promoting the delivery of products or drugs, removing sores, inducing skin to recover younger and producing new collagen and other biological reactions. The total delivery is low enough in the moon, typically less than about 5 〇 joules per square centimeter, and less than about 10 joules per square centimeter for most uses. In this embodiment, the absorbing layer can be designed to allow light to pass through. For example, blue or ultraviolet light can be emitted to interact with the skin and directly kill the bacteria. When δ is heated to treat a skin condition, heat can be applied pulsed or non-pulsed. The preferred therapeutic use temperature system is above about 6 rc. The preferred temperature | & surround is from about 67C to about 4GG °C. In a preferred embodiment, the elevated temperatures disclosed herein can be applied to the skin, and when applied at a low temperature for a short period of time, for example, application of less than about ice time will not cause burns. The temperature described herein can be the temperature of the heating element of the device used, and/or can be the temperature at the site of application to the skin. Typically, when the contact between the heating element and the skin surface is good, the temperature of the heating element is equal to the temperature of the skin surface. Another preferred temperature range is from about 10 Torr to about 4 Torr. Yet another preferred range 20 is from about 75 ° C to about. In one embodiment, the heating element can be applied to a temperature of from about thief to about 1 Torr in less than about 0.05 seconds and then allowed to cool through heat transfer into the skin. A method of applying a pulse to the skin by applying a heating element to the skin, such as after: the heating element is raised to at least less than about 〇·5 seconds, and the removal of the spoon 200C is then allowed to cool for about 15 seconds and then for about 5 seconds. 17 200800095 rises to about 130 ° C. This pulsed visualization needs to be repeated. Preferably, the peak temperature system is above about 67 ° C, above about 70 ° C, above about 75 ° C, above about 80 ° C, above about 85. (:, above about 90 ° C, above about 100 ° C, above about USt: above about 150 ° C, above about 175 ° C, above about 200. (:, above about 225 ° C, above about 250 ° C, above about 300 ° C, above about 350 ° C, above about 400 C, and above about 450 ° C. Furthermore, the peak temperature achieved is less than about 67 ° C, less than about 70 ° C, less than about 75 ° C, less than about 80 ° C, less than about 85 ° C, less than about 90 ° C, less than about 100 ° C, less than about 125 ° C , less than about 15 ° C, less than about 175 ° C, less than about 200 ° C, less than about 225 ° C, less than 10 about 250 ° C, less than about 300 ° C, less than about 350 ° C, less than about 400 ° C, and less than about 450 ° C. In one embodiment, the time to reach the peak temperature of the heating element (and thus the peak temperature of the skin surface) for pulsed use and/or non-pulsing use is less In seconds to about 3 seconds. The preferred time includes about 〇. 〇 5 seconds, about (^ seconds, about seconds, about 〇 · 3 15 seconds, about 〇 · 4 seconds, about 0. 5 seconds, about 〇.6 Seconds, about 0.7 seconds, about 0.8 seconds, about 0.9 seconds, about 1 second, about 1.5 seconds, and about 2.0 seconds. In several embodiments, the temperature of the heating element is allowed to decay by its peak temperature. The heating application time of the pulse embodiment and/or the non-pulsing embodiment (i.e., the time at which the temperature of the heating element is above the target value) is from less than about 丨 seconds to about 3 20 seconds. Other possible times include about 0.05 seconds. , about 1 second, about 2 seconds, about 0.3 seconds, about 0.4 seconds, about 0.5 seconds, about 6 seconds, about 7 seconds, about 8 seconds, about 0.9 seconds 'about 1 second' about 1.5 Seconds, and about 2 sec. In the pulsed embodiment, the time intervals between the heating pulses may be the same or may be opposite. When pulsing heat to the skin, before applying the second heat pulse, 18 200800095 The heating element is allowed to cool. The cold and light (4) appearance is lower than about the pit, lower than about 3Gt: lower than about the pit, lower than about thief is lower than about 45 C, and the spoon is 50C, less than about 55〇. c, less than about 6 percent, less than about, less than '47 GC, less than about 75 c, and below touch t. The time between two pulses includes less than about 5 seconds, less than about 4 seconds, less than _ , less than about 2 seconds, or less than about 1 second. Figure 1 shows a cross-sectional view of an embodiment of the hand-held processing device (4). The device is placed on the circuit board 3 The control unit is powered by an electric battery 20. The circuit board 3 is powered by a power supply or other user input device to charge the capacitor 25, and the capacitor 25 stores enough heating elements (such as a thin electric resistance heater) 32 to The required temperature (about 7 〇. to about ° ° C), and _ higher than (four) t to about · t temperature (but not necessarily a strange temperature) to go through the required time. When the button is pressed, the capacitor自动 Automatically discharges via resistor 15 32. The circuit then recharges the capacitor and the circuit is ready to fire again within a few seconds. To reduce the risk of accidental burns, the heating element is allowed to cool before it can fire another heat pulse. When used in multi-pulse mode, the unit automatically delivers multiple heating pulses without the user's additional input. In one embodiment, a temperature sensor (eg, thermocouple) 34 monitors the temperature of the 20 heating elements and interacts with the controller on circuit board 30 to prevent the second heating pulse until the temperature drops below an acceptable temperature ( For example, about 4 ° C). Thin resistive heaters are typically made of metal [e.g. nickel-chromium alloy (alloy of nickel and chromium), tungsten, aluminum, copper, gold, steel], with a typical thickness of less than 200 microns. Yumi Co., Ltd. (Shijia? [Stolen Giga, 19 200800095 k) (tei/ZCTw.minC〇x〇mA also has suitable thin film resistors (such as Thermofoil heaters). Other suitable thin film resistors are available. From Kyocera, Inc., in one embodiment, the user may select a different power level or a multi-pulse 5 rush heating type. For example, as shown in Figure 1, button 26 can be used to select high power. Set and low power settings. In addition, a single press of the button can be used to power the unit and select the operating mode. For example, press the button to activate the unit with a low φ power setting and press the button again to change to High power setting; the second press of the button changes to multi-pulse heating 。. Each press of the 10 button will cycle through all possible modes. This mode can be displayed by a series of LEDs or small LCDs. The braided LED % can also be integrated into the 驴 to provide illumination and lion treatment. For example, blue and red light can be used. Instead of using high / low switch and off / on switch, the device can use a single button to select the desired operating mode I5 &l t;. For money, press to hide the second to turn the device on or off. When • &〇n press the button for a short time, causing the device to switch the operating mode. This allows the device to be extremely broad. The modes include complex multi-pulse sequences for operation. Figures 2, 3 and 4 show that a specific embodiment can replace the heating element 32. The thick backing layer 5 shown in Figures 2 and 4 is used to add strength to the heating element while The heat can also be conducted away from the thin resistive heater 52. In one embodiment, the thin protective layer 50 can cover the resistive heater. In the preferred embodiment, the protective layer 5 is an electrical insulator with good thermal conductivity. The protective layer 5〇 reduces the risk of electric shock to the user and can be used to improve the temperature uniformity across the surface of the heating element. In addition, the thin electric resistance heater 52 can be chemically treated (eg, 200800095, anodized) Provides a very thin insulating layer to protect the user from electric shock. For most applications, the thin resistive heater 52 and optionally the protective layer 50 are less than 500 microns thick to limit heating of the material to the desired peak. Warm total This also limits the maximum energy that can be transferred to the tissue, 5 thereby reducing the risk of burns. The temperature sensor 34 shown in Figures 2 and 4 can be integrated into the backing layer 54 to monitor the temperature. For most applications, the surface area of the skin contacting surface of the heating element is about 1 square centimeter. The heating element of the present invention can be rapidly cooled by heat conduction into the tissue (or, if a backing layer is present, can be conducted into the backing layer) The maximum energy that can be transmitted to the skin can be controlled by the peak temperature and thickness of the heating layer. For example, when the 100 μm thick absorbing glass layer is heated to 300 ° C, it can be transferred to about 3 (rc tissue). The available energy is approximately 5.7 Joules per square centimeter. For pulsed heating of thin heaters, the cooling time τ = (Δχ / π) 2ρ 〇 / / € from the thermal relaxation time can be estimated, where Δ χ is the thickness, ρ is the density, c is the specific heat, and κ is the heater Thermal conductivity. 15 for glass, relaxation time is about! · 2 seconds. For heating to 30 (TC thick 100 micron copper layer, transfer to about 3 (TC available energy is about 9 · 2 joules / cm 2 . Relaxation time is about 8.65 microseconds. By appropriate selection of heating pulse format and heating materials It can control the peak tissue temperature and heating history. Figure 5 shows another embodiment of the hand-held acne treatment device, which integrates the protective cover 20 to prevent the user from accidentally placing the device on the eyeball. Figure 6 shows the thin resistor A possible circuit in which the heater applies a pulse to the desired peak temperature. Switch 200 (S1) is turned off to actuate the device and charge capacitor 220 (C2). When the capacitor is fully charged, lamp 23 〇 LED (D3) is activated. The device is ready to be launched. When the launch switch 240 (S2) is activated, the 21 200800095 thyristor (TS1) is activated, and the capacitor 220 is discharged via the thin resistive heater 250. In a preferred embodiment, via a thin resistive heater The discharge has a time constant shorter than 10 milliseconds. After the emission, the capacitor 22 starts charging, and after a few seconds (depending on the battery and the resistance), the capacitor 220 is fully charged. 1 / 2CV2, where c is the capacitance of capacitor, v is the final voltage across the capacitor via the ▽ and select the appropriate value c value, the energy released may be maintained below the critical value of tissue burns.

Figure 7 is a block diagram showing the key components for controlling the heating of the resistance heater in the control electronics of the AC circuit. The user interface 71 can include a user interface 710 of the button, switch or touch screen for selecting the mode of operation of the component and generating pulses. The user interface 71 is input to a microprocessor 72 (e.g., pic16F676 sold by Microchip Inc.), and the microprocessor 720 controls the overall functions of the pulse generator 73. The power is supplied by battery 74 or directly from the power supply. The pulse generator 73 turns the voltage from the battery I5 74 转 to a high voltage, which can be used to charge the capacitor when the user presses the emission button, and the capacitor is discharged via the heater 750. The discharge is typically via a thin resistive heater' with a time f number shorter than 1 〇〇 millisecond. The maximum value of each pulse is 1/2 CV2, where C is the capacitance of the capacitor and v is the final voltage across the valley. By properly selecting C and V, the energy released can be kept below the critical value of tissue burns. microprocessor? The user's wheel is used to control the charging and emission of the device. The user can select the power and multi-pulse heating format to transfer heat to the tissue while avoiding burns. The pulse format that can be used consists of a series of constant energy pulses separated by less than 2 centimeters to maintain a near constant temperature below the surface of the skin. It is also possible to use 22 200800095 to attenuate the pulse train, each successive pulse having a decreasing energy. It is also possible to use a boost pulse train with a higher energy for continuous subtraction. By carefully adjusting the pulse train m per pulse, you can control the peak tissue temperature and the internal temperature of the tissue to prevent burns. Coordination - In the fourth embodiment, the interval between pulses is greater than 10 milliseconds but less than 5 seconds. Figure 8 shows that the time is poor. 4 〇 〇 守, § When applying a single heating pulse, the calculated track is 0.20 m, 〇 5 mm and 〖0 mm below the surface. • The peak temperature of the crucible is less than 0.1 second, which limits the risk of burns. 10 Figure 9 When the two heating pulses are applied to the heater, the temperature is calculated at 0.2, 0.5 and 1.0 mm below the surface. The first pulse has a peak temperature that can be generated by a higher total. After 2 seconds, the second pulse of half energy with the first pulse reheats the thin metal addition. As a result, the internal temperature of the tissue is higher than the 15 S degree produced by a single pulse having an equal total energy. The multi-pulse capability allows the device to be filled with New York tissue without exceeding the burn Φ scald threshold (the critical value of burn burn is a function of peak temperature). Ask the peak / dish know: time interval is critical to prevent skin burns. Hermques (Fc Henriques, "Thermal Injury Study: The Predictability and Significance of the Thermal Induction Program for Resulting Irreversible Epidermal Injury", Proceedings of the 20th Proceedings, Issue 43, May 5, 1947, pp. 489-502 Open the theory of skin burns based on the type Arrhenius equation for heat-induced irreversible chemical reactions. Although many other studies have studied the burn process, the conclusions are similar. The skin burns due to the change of the structure of the heat-induced protein, and the activation energy of the protein structure is about 600 23 200800095 MJ/kg-mo. For the skin, the Henriques integral equation can be written as: 0 Here is the depth\ Kjeldahl temperature scale, and τ is a function of time, and ω is a function of burn injury. The integration is performed over time and the temperature of the substrate layer is greater than or equal to 44 °C. When (0=1, a second degree burn occurs. When ω=〇·53, there is a degree of burn. At the bottom of the dermis (the threshold of 〇=1 occurs with a third degree burn. For normal operation of the device, under the skin More than 1 〇〇 micron depth ω < 0.4. For this reason, the risk of burns is extremely low. 10 15 Figure 10 shows how the invention is used to treat dark spots on the face. The device 1 〇 is actuated 'and then placed in contact with the skin. When the device is in good contact and fully charged, press the launch button to transfer energy to the heating element and then move it to the skin. A thermal pulse to the skin can be used to open the pores and accelerate the removal of the dark spots. In some cases, a single treatment can be used to treat dark spots effectively. In this case, the shortest time between treatments is controlled by the circuit, thus preventing misuse and possible burns. Alternatively, multiple treatments may be performed a week to treat certain dark spots. In another embodiment of the handheld acne treatment device, the control electronics have an operational mode in which the thin film resistor is pulsed with multiple currents. Pulses are applied to produce the desired heating profile. For example, the device is first pulsed to a high temperature for a period of 1 to 5 seconds as described above, producing a second pulse that reduces the current to reheat the thin film resistor. The pulse has a delay between the user-selected pulses and a variable peak temperature (or energy). The use of multiple pulses allows the user to achieve a higher temperature below the skin without damaging the skin. 24 20 200800095 Turning, the present invention encompasses the multiple skin-improving effects of the method of the present invention: - controlling the amount of heat placed on the surface via deposition, allowing energy to flow into the upper layer of the dermis to achieve controlled damage to the collagen of the upper dermis. Possible = 5 segments After the predetermined surface heating time, the cooling element can be actuated to remove heat from the skin surface, protect the skin surface from excessive exposure to heat, and reverse the heat energy from the deeper tissue of the dermis to the surface. - Allow temporary cleaning by temporarily magnifying the skin pores The pores cause the removal of undesired debris, dirt and contaminants, which leads to a reduction in pore size.经由• By temporarily magnifying the pores on the surface of the skin, 'allow nutrients, conditioning agents, and the Lele that can be used to flow into the deeper layers of the skin. _ By temporarily magnifying the pores on the surface of the skin, allowing the elimination of harmful sebum and bacteria, thus reducing the appearance Opportunities for acne and other sebaceous gland-related disorders 15 - Damage to the surface of the skin by heat, followed by fragmentation and removal of part of the stratum corneum, and part of the epidermis and part of the dermis. ' _ Heat damage to the skin surface (in the epidermis or upper dermis) The vascular component or pigment-containing component. The body can remove these undesired damaged components as waste and avoid ugly facial dark spots. 20 Methods of Use The device described herein can be used to treat various skin conditions and lesions. Examples of skin disorders and lesions are provided herein, but are not limited to the conditions and lesions described herein. Bacterial and fungal skin infections can cause fungal infections such as acne, acne, and under the finger. Other lesions may be caused by irritants, 25 200800095 Stimulants may be caused by insect bites or exposure to other natural or artificial skin irritants. Another common case in which skin lesions are caused by viral infections is a lesion called "cold sores" or "hot water bubbles". Other skin conditions include pus treatment of the dermis and epidermis, localized abscesses 5 formation, and localized inflammatory conditions. One of the most common conditions is a lesion caused by a condition called acne vulgaris. Acne vulgaris is associated with the gram-positive anaerobic acne propionibacterium acnes. The formation of abscesses may also be due to a variety of genus (mainly Staphylococcus and Streptococcus) and fungi such as dermatophytes. Another type of skin lesion is a viral skin lesion such as a cold sore, also known as a hot water bubble. Cold sores are often caused by Herpes Simplex strains and often cause lesions on the lips or near the lips and on the inside of the mouth. 15 Another type of skin lesion is a fungal infection, also known as fungal dermatitis, which is medically known as a drug, an athlete's foot, a claw, a hair, a sputum, and a sputum. A particularly troublesome condition, known as a claw carapace, is a fungal infection that occurs in the toenails or finger lice, and is also medically known as nail fungus or nail rim. Mycosis may be caused by several fungi including Trichophyton mentagrophytes, Candida albicans or Trichophyton mbrum. Qian Qian is also known as a round or slippery. Qian Qian refers to the body's rim. It is a smooth, hairless skin, that is, fungal infections or dermatophytes in areas other than the long beard area, scalp, groin, hands and feet. Disease, money 癖 is usually caused by the genus 26 200800095, such as Microsporum (Microcrpors), such as Bacillus licheniformis, Trichophyton, such as red hair fungus, hairworm and epidermis Epidermophyton, especially caused by fungi such as the genus Trichophyton and the genus Epidermidis. The condition usually involves the presence of a 5 or more defined erythema scaly mass with slightly elevated edges that heal in the middle to create an annular contour. A variety of other types of lesions may also occur, such as blisters, eczema-like, dry, sickle, plaque, or deep lesions. The femoral hernia is also commonly known as the "squatting itch" or the rim of the groin. The femoral hernia is a fungal infection or dermatophytosis of 10 kinds of groin, perineum, and perineal areas. It is common in men and occasionally develops into a continuous area. It is usually caused by fungal genus such as Bacillus, Brassica, and Epidermidis, especially caused by fungi such as Trichophyton and Epidermidis. The condition usually includes severe itching and sharply delimited lesions with elevated erythema edges and sparse 15 dry descaling. Occasionally, the stocks are accompanied by enough athletes (also known as "Hong Kong feet"). The ankle line leads to inter-finger lesions. The Hong Kong foot is a pruritic, odorous, uncomfortable condition caused by the proliferation of a large number of common non-virulent bacteria in the middle space of fungal infections. Some mosquito bites and exposure to certain plants may expose the skin to irritation, resulting in an itchy or painful immune response. Symptoms usually manifest as soon after the introduction of the irritant, but may continue to recur or occasionally recur for a prolonged period of time when the irritant is not effectively removed or the stimuli are not activated by the immune response. The present invention relates to a method and a device for treating a skin condition and a skin lesion, and relates to a tissue that can be applied to an infected tissue or a compliant tissue. The invention may also be used to treat skin vessels caused by bacterial, fungal or viral infections by the application of a defined amount of heat. A skin condition or skin lesion to be treated according to the present invention is any infected tissue or stimulating tissue that can be effectively treated by heat application. The lesion may be caused by strains of infected bacteria including, but not limited to, strains such as oleic acid bacteria, staphylococcus or streptococci. In a preferred embodiment, the present invention provides methods and devices for treating skin lesions such as common and common skin lesions. Such skin lesions include abdominal cell therapy, 10 and limited abscesses such as cysts, nodules, should be 'cells, acupoints, acne (blackheads). These lesions include those commonly known as face running, white head (four), youth: sores and other lesions. Additionally or alternatively, the lesion may be caused by a fungal genus including, but not limited to, U fungal genus that may produce, for example, toenail or finger lice, rims, and the like. Such fungal genus includes, for example, Bacillus licheniformis, such as T. rubrum, T. faecalis, T. faecalis, and white rosary. These fungi are occasionally referred to as "skin" in a broad sense. Additionally or alternatively, in other embodiments, the skin lesion may be caused by a viral infection, including caused by a critically ill virus such as simple type I and type II (cold sore 20 and genital herpes), herpes zoster (chicken pox), and the like. Infection. Additionally or alternatively, embodiments of the present invention provide methods and apparatus for applying heat to treat skin lesions caused by stimuli. Common skin irritants which can be treated using the present invention include stimuli introduced through insect bites such as mosquitoes, sand mites, ants, spider bites, acne, and the like. Other skin irritants introduced by plants such as jellyfish, 200800095 snakes, or via plants such as poison ivy, poisonous oak, poison paint, etc. can also be treated using the methods and devices of the present invention. For the purposes of the present invention, "treating" a skin lesion or skin condition means slowing, stopping or even reversing the development of a skin lesion or skin condition, and reducing the healing time of the condition or condition. Efficacy can be achieved by eradicating or ameliorating the underlying condition being treated, such as eradicating or ameliorating and/or eradicating or ameliorating one or more physiological or psychological symptoms associated with the condition being treated, but the patient may still have the potential Illness. The lexicons such as "individual" and "animal individual" as used herein refer to humans but may also include other suitable animals. Examples Heat treatment for acne: Figure 11 shows the device used to treat mild to moderate acne

After the W lesions, the individual treatments [photographs and the total number of fifth recorded lesions on the last day, the facial photographs of the severely treated lesions and the facial photos of the subsequent day photos were used for silk evaluation 29 200800095 The location of the lesion is graded and compared. Grading is performed by a rating system. Individual facial lesions are assigned a number to classify each lesion. The following is a review of the evaluation system for individual acne lesions: -1 point - mild lesions - height is the height of the skin surface or rarely increased disease 5 lesions, very few erythema. - 2 points - moderate lesions - visually visible lesions, 2 mm from the surface of the skin, moderate erythema (0.5 mm - 1 mm), with or without undulations. ^ - 3 points - severe lesions - visually visible lesions, protrusions 2 mm or more - erythema extension greater than 1 mm, with or without undulations, openness or closure, may flow 10 serous or no. The final score is the sum of individual lesions that all receive ratings. This score - is determined on the first day before the baseline of treatment. For each treatment, a single acne lesion was scored with the total score as the patient score for that day. At the end of the 〆 (5th day), the final score is determined from the total score of all individual lesions. The lesions were divided into 15 to 1 to indicate that the lesion was relieved. The results in Figure 11 show that the treated acne ^ is more rapidly relieved than the untreated blister. The invention may also be combined with topical mucilages or creams to improve the treatment of skinny. For example, a benzoic acid benzoquinone-containing gel may be applied topically after treatment with the device. For best results, the treatment area is first washed with 20 mild soaps or detergents. After washing the area to be treated, the device is used at least once and then a topical acne gel is applied. This process is usually repeated twice a day. The foregoing description is for illustrative purposes only and is not intended to limit the invention. Persons skilled in the art may use known equivalents to replace the structures and devices described herein. The full scope and definition of the invention is therefore set forth in the appended claims. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 shows a cross-sectional view of a hand-held acne treatment device that uses a thin film resistor to deliver energy into the interior of the skin. Figure 2 shows a cross-sectional view along one embodiment of a heating element that includes a backing layer. Figure 3 shows a cross-sectional view taken along another embodiment of the heating element. Figure 4 shows a cross-sectional view taken along another embodiment of the heating element. Figure 5 shows another embodiment of a hand-held acne treatment device incorporating a shield. Figure 6 shows a possible circuit for applying a pulse to a thin film resistor. Figure 7 shows a block diagram of a device that uses a microprocessor to allow a user to apply different sequences of heating pulses. Figure 8 shows the temperature history of a single heating pulse at different tissue depths from the surface. 20 Figure 9 shows the temperature history of two different heating pulses (0 sec and 2.0 sec) with the same total energy as in Figure 8, at different tissue depths from the surface. Figure 10 shows how the device is used to treat facial dark spots. Figure 11 shows the healing effect of acne after using heat treatment. 31 200800095 Main component symbol description] 10... Handheld therapy device 54... Back layer 20... Battery 180... Shield 22... Power switch 200... Switch 24... Button 220. Capacitor 25...Capacitor 230...Lamp, LED 26...Button 240...Transmission switch 30...Circuit board, heating element 250...Thin type resistance heater 32...Resistor 710...Use Interface 34...temperature sensor, thermocouple 720...microprocessor 38...LED, light emitting diode 730...pulse generator 50...thin protective layer 740...battery 52 ...thin type resistance heater 750...thin type resistance heater 32

Claims (1)

200800095 X. Patent application scope: h A device for treating skin diseases, comprising: a heating element suitable for and in contact with the surface of the skin; and a control device, the controller is suitable for assembly with less than about seconds Heating the heating element to at least about 7 (TC temperature) for 5 cycles, maintaining the heating element at least about 7 响应 in response to user input for less than i seconds. 2. As in the old device of the patent application, Wherein the controller is further adapted to the input of the additional user without stopping, and the heating of the heating element is stopped, 10 and the heating element is reheated. 3. = the old device of the patent application, wherein the heating element and the controller are Located inside the casing, the casing can be held in the user's hand. 4. The device for treating skin diseases comprises a casing suitable for being assembled in the hand of the user, the casing comprising - suitable a heating element assembled to contact the skin surface 15; and a controller adapted to heat the heating element to at least about 7 in a time period of less than about 1 second Its temperature, in response to user input, maintains the heating element at a temperature of at least about 70 ° C for a small second of time; and is suitable for assembling a user interface that is activated by the user to provide user input. The device of claim 4, wherein the controller is further adapted to replace the heating of the heating element without re-heating, and to reheat the heating element. 6. A device for treating a skin condition, comprising: - suitable Arranged to be placed on the surface of the skin facing away from the treatment. 33 200800095 Thermal element; assembled to fit by the user, support the handle area of the heating element when placed against the surface of the skin, and suitable for heating and heating The device is subjected to a heating circuit having a temperature of at least about 67 ° C for less than about 0.1 seconds. 7. The device of claim 6 wherein the heating circuit comprises a suitable and assembled device responsive to user input, controlled by a controller for the heat generated by the heating element. 8. The device of claim 7 wherein the controller is further adapted to The input of the additional user, the heating of the heating element is stopped, and the heating element is reheated. 9. The device of claim 1, 4 or 6, wherein the heating element comprises an electric resistance heater. The device of claim 9 wherein the electric resistance heater is a thin type 15 metal resistor. 11. The device of claim 1, wherein the heating element comprises a material selected from the group consisting of nichrome, A metal of the group consisting of tungsten, ingot, gold, copper and/or steel. 12. The device of claim 1, 4 or 6, wherein the heating element 20 comprises a backing layer and an electrical insulation protection a layer, and/or a highly conductive layer. 13. The device of claim 1, wherein the skin contacting surface of the heating element has a surface area of about 1 square centimeter. 14. A device as claimed in claim 1, 4 or 6, wherein the temperature is from about 75 ° C to about 10 ° C. 34 200800095 15. The device of claim 4, wherein the temperature is from 100 ° C to about 200 ° C. 16. In the case of the application of patent scope 4 or 6, the temperature is achieved in a time period of less than about 0.5 seconds. 5. The device of item 4, 4 or 6, wherein the total energy delivered to the skin is less than about 5 〇 joules per square centimeter. 18. The device of claim i, 4 or 6, wherein the total energy delivered to the skin is less than about 5 Joules per square centimeter. 19. The apparatus of claim 1, 4 or 6, wherein the step further comprises a 1 degree sensor, the temperature sensing 11 being adapted and configured to sense the temperature of the heating, and controlling the The temperature of the heating element. 20. The device of claim 4, 4 or 6 further comprises a component 'the cooling element is adapted to cool the addition and subtraction and the surface of the skin to a temperature below about 60 °C. 3 15 ‘As for the device of the patent scope Scope (4), the step further includes a photodiode. X 22. The skirt of claim 6 wherein the heating circuit is adapted to heat the heating element to at least the machine temperature for less than about 2 seconds, and the temperature of the heating element is reduced to a period of about 5 seconds. And re-energizing the heating element to at least a temperature of less than about 〇] seconds. The device of claim 4, wherein the user interface is activated by a user to heat the heating element to a peak temperature of about i milliseconds. The peak temperature is less than about G5. The second time decays to about coffee. c 24. A method of treating a skin condition comprising heating the skin surface of a body of the group to a temperature of at least about 7 (the temperature of the rc is less than m seconds). 25. As claimed in claim 24 The method further comprises the step of stopping the heating for a period of from about 1 millisecond to about 5 seconds, and then heating the skin surface to at least about 7 Torr again. The temperature is less than about ten seconds. A. In the method of item 25, the step of step 0 includes repeating the step of stopping the heating and the step of reheating. 27. A method of treating a skin condition by applying at least two heating pulses to the surface of the skin to raise the surface of the skin to at least about The temperature of 赃 can be achieved by borrowing pulses in less than about 1 second. 28, as in the method of claim 27, the step-by-step includes providing attenuation between the heating pulses to allow the surface of the skin to reach a temperature lower than about thief. 29. The method of claim 2, wherein the method comprises applying a topical substance to the surface of the skin before, during and/or after the application of the peak temperature. The method of claim 24, wherein the dermatological condition is selected from the group consisting of acne, night, cold sores, and/or skin enemies. The method of claim 24 or 27, wherein the temperature system Maintaining a temperature of less than about 7 ° C for less than about 1 second. 32. - A method of diligently treating a skin condition, comprising applying a reduction to the surface of the skin, heating the heat source to a peak temperature above about 67 ° C is less than about 〇 33. As in the method of claim 32, the step of including the step of stopping the heating is carried out for a period of from about 10 milliseconds to about 5 seconds, and then the surface of the skin is again added 36 200800095 to a temperature of at least about 70 ° C. A time of about 1 second. 34. The method of claim 33, further comprising repeating the step of stopping the heating and the step of reheating. 37