TW200732314A - Substituted thiazoles and their use - Google Patents

Substituted thiazoles and their use

Info

Publication number
TW200732314A
TW200732314A TW095139076A TW95139076A TW200732314A TW 200732314 A TW200732314 A TW 200732314A TW 095139076 A TW095139076 A TW 095139076A TW 95139076 A TW95139076 A TW 95139076A TW 200732314 A TW200732314 A TW 200732314A
Authority
TW
Taiwan
Prior art keywords
compound
directed
compounds
oab
channel
Prior art date
Application number
TW095139076A
Other languages
Chinese (zh)
Inventor
Joseph P Marino
Haifeng Cui
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of TW200732314A publication Critical patent/TW200732314A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention is directed to novel substituted thiazole compounds. Specifically, the invention is directed to compounds according to Formula I: wherein R1 and R2 are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds are large conductance calcium -activated K channel (BKCa channel) openers, which can be used in the treatment of urinary conditions, including OAB, Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of treating urinary conditions, such as OAB, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
TW095139076A 2005-10-26 2006-10-24 Substituted thiazoles and their use TW200732314A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73029805P 2005-10-26 2005-10-26

Publications (1)

Publication Number Publication Date
TW200732314A true TW200732314A (en) 2007-09-01

Family

ID=37968661

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095139076A TW200732314A (en) 2005-10-26 2006-10-24 Substituted thiazoles and their use

Country Status (4)

Country Link
AR (1) AR056720A1 (en)
PE (1) PE20070530A1 (en)
TW (1) TW200732314A (en)
WO (1) WO2007051133A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009125870A1 (en) 2008-04-09 2009-10-15 Mitsubishi Tanabe Pharma Corporation Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers.
KR102676631B1 (en) * 2020-10-07 2024-06-19 광주과학기술원 Composition for preventing or treatment of overactive bladder

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746741A (en) * 1986-06-19 1988-05-24 Eastman Kodak Company N,N'-bis[2-(3-methylphenyl)ethyl]-perylene-3,4:9,10-bis (dicarboximide) compound use thereof in multi-active photoconductive insulating elements exhibiting far red sensitivity
IE73235B1 (en) * 1991-03-25 1997-05-21 Akzo Nv 4-aryl-thiazole or imidazole derivatives
HU208429B (en) * 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
JP4073786B2 (en) * 2001-04-16 2008-04-09 田辺三菱製薬株式会社 High conductance calcium-sensitive K channel opener
GB0121033D0 (en) * 2001-08-30 2001-10-24 Novartis Ag Organic compounds
US7057040B2 (en) * 2002-02-07 2006-06-06 Council Of Scientific And Industrial Research Substituted aryl alkenoic acid heterocyclic amides

Also Published As

Publication number Publication date
WO2007051133A2 (en) 2007-05-03
PE20070530A1 (en) 2007-05-31
WO2007051133A3 (en) 2007-12-13
AR056720A1 (en) 2007-10-17

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