TW200730516A - Cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals - Google Patents

Cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals

Info

Publication number
TW200730516A
TW200730516A TW095135656A TW95135656A TW200730516A TW 200730516 A TW200730516 A TW 200730516A TW 095135656 A TW095135656 A TW 095135656A TW 95135656 A TW95135656 A TW 95135656A TW 200730516 A TW200730516 A TW 200730516A
Authority
TW
Taiwan
Prior art keywords
disorders
thiadiazol
cyclic
processes
pharmaceuticals
Prior art date
Application number
TW095135656A
Other languages
Chinese (zh)
Inventor
Karl Schoenafinger
Stefanie Keil
Matthias Urmann
Hans Matter
Maike Glien
Wolfgang Wendler
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of TW200730516A publication Critical patent/TW200730516A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARgamma agonist activity. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.
TW095135656A 2005-10-06 2006-09-27 Cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals TW200730516A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05021785 2005-10-06

Publications (1)

Publication Number Publication Date
TW200730516A true TW200730516A (en) 2007-08-16

Family

ID=35459548

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095135656A TW200730516A (en) 2005-10-06 2006-09-27 Cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals

Country Status (2)

Country Link
MY (1) MY140251A (en)
TW (1) TW200730516A (en)

Also Published As

Publication number Publication date
MY140251A (en) 2009-12-31

Similar Documents

Publication Publication Date Title
TN2009000242A1 (en) Sulfonyl-phenyl-2h-[1,2,4]oxodiazol-5-one derivatives, processes for their preparation and their use as pharmaceuticals
MX2010006647A (en) Cyclic pyridyl-n-(1,3,4)-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals.
MY148982A (en) Phenyl-1,2,4-oxadiazolone derivative with phenyl group, processes for their preparation and their use as pharmaceuticals
TNSN08148A1 (en) Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
TW200602342A (en) Oxadiazolones, processes for their preparation and their use as pharmaceuticals
TW200621732A (en) Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
MX2007002689A (en) 7-azaindoles and their use as ppar agonists.
WO2006099943A8 (en) Amide-substituted 8-n-benzimidazoles, method for the production thereof, and use of the same as medicaments
TW200510352A (en) Cycloalkyl substituted amino acid derivatives, processes for their freparation and their use as pharmaceuticals
NO20081682L (en) 4-Oxy-N- [1,3,4] -thiadiazol-2-yl-benzenesulfonamides, process for their preparation and their use as pharmaceuticals
TW200612903A (en) Use of trisubstituted benzopyranones
TW200505880A (en) Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceuticals
NO20081681L (en) N- [1,3,4] -thiadiazol-2-yl-benzenesulfonamides, process for their preparation and their use as pharmaceuticals
NO20081675L (en) Cyclic N- [1,3,4] -thiadiazol-2-yl-benzenesulfonamides, process for their preparation and their use as pharmaceuticals
WO2007039174A3 (en) Bicyclic aryl-sulfonic acid [1,3,4]-thiadiazol-2-yl-amides, processes for their preparation and their use as pharmaceuticals
TW200732328A (en) Derivatives of 2-aminothiazoles and 2-aminooxazoles, processes for their preparation and their use as pharmaceuticals
MX2010008706A (en) Phenyl-prenyl derivatives, of marine and synthetic origin, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders.
TW200730516A (en) Cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals
TW200505830A (en) Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
WO2006099940A8 (en) Substituted, bicyclic 8-pyrrolidino-benzimidazoles, method for their production and their use as medicaments
TW200505831A (en) Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals
TW200738654A (en) Alkoxymethyl-substituted benzoic acid derivatives, process for their preparation and their use as medicaments
TW200508229A (en) Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
TW200621733A (en) Acetic acid derivatives with cyclohexylmethoxy substituents, process for their preparation and their use as medicaments
TH88493B (en) 4- Oxy-N- [1,3,4] -thyadiazole-2-il-benzene sulfonamides, processes for preparing them and their use as pharmaceutical substances.