TW200718436A - Collagen II/glycosaminoglycan/hyaluronan porous matrix and preparation thereof - Google Patents

Collagen II/glycosaminoglycan/hyaluronan porous matrix and preparation thereof

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Publication number
TW200718436A
TW200718436A TW094139016A TW94139016A TW200718436A TW 200718436 A TW200718436 A TW 200718436A TW 094139016 A TW094139016 A TW 094139016A TW 94139016 A TW94139016 A TW 94139016A TW 200718436 A TW200718436 A TW 200718436A
Authority
TW
Taiwan
Prior art keywords
hyaluronan
collagen
porous matrix
glycosaminoglycan
matrix
Prior art date
Application number
TW094139016A
Other languages
Chinese (zh)
Other versions
TWI265035B (en
Inventor
I-Ming Chu
Shih-Sheng Ko
Original Assignee
Univ Nat Tsing Hua
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nat Tsing Hua filed Critical Univ Nat Tsing Hua
Priority to TW94139016A priority Critical patent/TWI265035B/en
Application granted granted Critical
Publication of TWI265035B publication Critical patent/TWI265035B/en
Publication of TW200718436A publication Critical patent/TW200718436A/en

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Abstract

The present invention provides a porous matrix of collagen II/glycosammoglycan/hyaluronan, which can supply environment of cell adhesion, proliferation, migration and differentiation. The porous matrix is prepared by crosslinking collagen II, glycosaminoglycan and hyaluronan in the presence of a crosslinking agent, and the resulting sponge matrix possesses interconnected pores with mean diameters of 50~300 μm and porosity of 90-95%. It can be used as a tissue-engineered matrix providing a good cell proliferation and differentiation environment for hyaline cartilage and mesenchymal stem cells (MSCs).
TW94139016A 2005-11-07 2005-11-07 Collagen II/glycosaminoglycan/hyaluronan porous matrix and preparation thereof TWI265035B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW94139016A TWI265035B (en) 2005-11-07 2005-11-07 Collagen II/glycosaminoglycan/hyaluronan porous matrix and preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW94139016A TWI265035B (en) 2005-11-07 2005-11-07 Collagen II/glycosaminoglycan/hyaluronan porous matrix and preparation thereof

Publications (2)

Publication Number Publication Date
TWI265035B TWI265035B (en) 2006-11-01
TW200718436A true TW200718436A (en) 2007-05-16

Family

ID=38122054

Family Applications (1)

Application Number Title Priority Date Filing Date
TW94139016A TWI265035B (en) 2005-11-07 2005-11-07 Collagen II/glycosaminoglycan/hyaluronan porous matrix and preparation thereof

Country Status (1)

Country Link
TW (1) TWI265035B (en)

Also Published As

Publication number Publication date
TWI265035B (en) 2006-11-01

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MM4A Annulment or lapse of patent due to non-payment of fees