TW200643415A - Technology for the determination of impurities in TRODAT-1 raw material - Google Patents

Technology for the determination of impurities in TRODAT-1 raw material

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Publication number
TW200643415A
TW200643415A TW094119601A TW94119601A TW200643415A TW 200643415 A TW200643415 A TW 200643415A TW 094119601 A TW094119601 A TW 094119601A TW 94119601 A TW94119601 A TW 94119601A TW 200643415 A TW200643415 A TW 200643415A
Authority
TW
Taiwan
Prior art keywords
raw material
trodat
impurities
liquid chromatography
hplc
Prior art date
Application number
TW094119601A
Other languages
Chinese (zh)
Other versions
TWI304131B (en
Inventor
Kung-Tien Liu
Yi-Chih Hsia
Chang-Yung Su
Chiung-Fang Huang
Ying-Kai Fu
Original Assignee
Inst Nuclear Energy Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Inst Nuclear Energy Res filed Critical Inst Nuclear Energy Res
Priority to TW94119601A priority Critical patent/TWI304131B/en
Publication of TW200643415A publication Critical patent/TW200643415A/en
Application granted granted Critical
Publication of TWI304131B publication Critical patent/TWI304131B/en

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Abstract

This invention discloses a novel technology for the impurities assay of TRODAT-1 raw material by reverse phase high performance liquid chromatography (RP-HPLC). The method for TRODAT-1 raw material impurities assay of this present invention includes using high performance liquid chromatography (HPLC), liquid chromatography tandem mass spectrometry (LC-MS/MS), HPLC column, preparation of samples, regents and eluent as well as performing parent and product ion analysis by mass spectrometry for the method validation, calculation of chromatography resolution and raw material impurities. This invention is the first report in the world that proved the existence of oligomers in TRODAT-1 raw material as well as an elaborated analysis through validation procedures.
TW94119601A 2005-06-14 2005-06-14 Technology for the determination of impurities in trodat-1 raw material TWI304131B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW94119601A TWI304131B (en) 2005-06-14 2005-06-14 Technology for the determination of impurities in trodat-1 raw material

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW94119601A TWI304131B (en) 2005-06-14 2005-06-14 Technology for the determination of impurities in trodat-1 raw material

Publications (2)

Publication Number Publication Date
TW200643415A true TW200643415A (en) 2006-12-16
TWI304131B TWI304131B (en) 2008-12-11

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ID=45070870

Family Applications (1)

Application Number Title Priority Date Filing Date
TW94119601A TWI304131B (en) 2005-06-14 2005-06-14 Technology for the determination of impurities in trodat-1 raw material

Country Status (1)

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TW (1) TWI304131B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI426265B (en) * 2010-09-29 2014-02-11 Iner Aec Executive Yuan An automatic analysis method of technetium
TWI577990B (en) * 2015-09-25 2017-04-11 行政院原子能委員會核能研究所 High performance liquid chromatography method for analyzing imaging agent, precursor of imaging agent, or intermediate of imaging agent

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI426265B (en) * 2010-09-29 2014-02-11 Iner Aec Executive Yuan An automatic analysis method of technetium
TWI577990B (en) * 2015-09-25 2017-04-11 行政院原子能委員會核能研究所 High performance liquid chromatography method for analyzing imaging agent, precursor of imaging agent, or intermediate of imaging agent

Also Published As

Publication number Publication date
TWI304131B (en) 2008-12-11

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