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Application filed by Egen CorpfiledCriticalEgen Corp
Publication of TW200643029ApublicationCriticalpatent/TW200643029A/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
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Abstract
The invention provides PEG-IFN α-1b conjugates, where a PEG moiety is covalently bound to Cys86 of human IFNα-1b conjugates. A pharmaceutical composition and a method for treating inflammatory diseases, infections, and cancer are also provided. The invention further relates to a method for the modification of interferons by conjugation of a PEG moiety to free cysteine residues in interferon molecules.
Method for producing sterile suspensions or lyophilisates of poorly soluble basic peptide complexes. pharmaceutical formulations containing the same, and use thereof as medicaments