TW200602353A - Modified secretin and method of synthesizing thereof - Google Patents
Modified secretin and method of synthesizing thereofInfo
- Publication number
- TW200602353A TW200602353A TW094118873A TW94118873A TW200602353A TW 200602353 A TW200602353 A TW 200602353A TW 094118873 A TW094118873 A TW 094118873A TW 94118873 A TW94118873 A TW 94118873A TW 200602353 A TW200602353 A TW 200602353A
- Authority
- TW
- Taiwan
- Prior art keywords
- peptide
- terminus
- amino acid
- blood component
- modified
- Prior art date
Links
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a reactive group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW94118873A TWI319766B (en) | 2000-06-19 | 2000-06-19 | Modified insulin derivatives and conjugates thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW94118873A TWI319766B (en) | 2000-06-19 | 2000-06-19 | Modified insulin derivatives and conjugates thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200602353A true TW200602353A (en) | 2006-01-16 |
TWI319766B TWI319766B (en) | 2010-01-21 |
Family
ID=45073659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW94118873A TWI319766B (en) | 2000-06-19 | 2000-06-19 | Modified insulin derivatives and conjugates thereof |
Country Status (1)
Country | Link |
---|---|
TW (1) | TWI319766B (en) |
-
2000
- 2000-06-19 TW TW94118873A patent/TWI319766B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TWI319766B (en) | 2010-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |