TW200505937A - Methods and compositions for identifying modulators of g protein-coupled receptors - Google Patents
Methods and compositions for identifying modulators of g protein-coupled receptorsInfo
- Publication number
- TW200505937A TW200505937A TW093112289A TW93112289A TW200505937A TW 200505937 A TW200505937 A TW 200505937A TW 093112289 A TW093112289 A TW 093112289A TW 93112289 A TW93112289 A TW 93112289A TW 200505937 A TW200505937 A TW 200505937A
- Authority
- TW
- Taiwan
- Prior art keywords
- gpcr
- ligand
- upregulatable
- coupled receptors
- modulators
- Prior art date
Links
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- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The subject invention provides methods for making ligand upregulatable G-protein coupled receptors (GPCRs). Ligand upregulatable GPCRs contain a modified TM5-IC3-TM6 segment, which provides for increased levels of the ligand upregulatable GPCR I a host cell in the presence of a ligand as compared to the absence of the ligand. The subject invention also provides assays for screening test compounds for a ligand of a GPCR using a ligand upregulatable GPCR. In these assays, a ligand upregulatable GPCR is contacted with a test compound, and an increase in the detectable amount of the ligand upregulatable GPCR in the host cell indicates that the test compound is a ligand of the GPCR. Said indicated ligands encompass modulators of the GPCR. Said modulators of the GPCR are particularly useful in treating GPCR-related conditions.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46748903P | 2003-04-30 | 2003-04-30 | |
US51616803P | 2003-10-31 | 2003-10-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200505937A true TW200505937A (en) | 2005-02-16 |
TWI347949B TWI347949B (en) | 2011-09-01 |
Family
ID=46765590
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW093112289A TWI347949B (en) | 2003-04-30 | 2004-04-30 | Methods and compositions for identifying modulators of g protein-coupled receptors |
TW100118780A TW201131168A (en) | 2003-04-30 | 2004-04-30 | Methods and compositions for identifying modulators of G protein-coupled receptors |
TW100122527A TW201144436A (en) | 2003-04-30 | 2004-04-30 | Methods and compositions for identifying modulators of G protein-coupled receptors |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW100118780A TW201131168A (en) | 2003-04-30 | 2004-04-30 | Methods and compositions for identifying modulators of G protein-coupled receptors |
TW100122527A TW201144436A (en) | 2003-04-30 | 2004-04-30 | Methods and compositions for identifying modulators of G protein-coupled receptors |
Country Status (1)
Country | Link |
---|---|
TW (3) | TWI347949B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7297214B2 (en) * | 2017-09-28 | 2023-06-26 | 国立大学法人京都大学 | Fish and methods of producing fish |
-
2004
- 2004-04-30 TW TW093112289A patent/TWI347949B/en not_active IP Right Cessation
- 2004-04-30 TW TW100118780A patent/TW201131168A/en unknown
- 2004-04-30 TW TW100122527A patent/TW201144436A/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW201131168A (en) | 2011-09-16 |
TWI347949B (en) | 2011-09-01 |
TW201144436A (en) | 2011-12-16 |
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Legal Events
Date | Code | Title | Description |
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MM4A | Annulment or lapse of patent due to non-payment of fees |