TW200505836A - Cyclic sulfonamides for inhibition of gamma-secretase - Google Patents

Cyclic sulfonamides for inhibition of gamma-secretase

Info

Publication number
TW200505836A
TW200505836A TW093112929A TW93112929A TW200505836A TW 200505836 A TW200505836 A TW 200505836A TW 093112929 A TW093112929 A TW 093112929A TW 93112929 A TW93112929 A TW 93112929A TW 200505836 A TW200505836 A TW 200505836A
Authority
TW
Taiwan
Prior art keywords
secretase
gamma
inhibition
cyclic sulfonamides
sulfonamides
Prior art date
Application number
TW093112929A
Other languages
Chinese (zh)
Inventor
Kevin Dinnell
Timothy Harrison
Alan John Nadin
Andrew Pate Owens
Duncan Edward Shaw
Brian John Williams
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of TW200505836A publication Critical patent/TW200505836A/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compounds of formula I: , inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
TW093112929A 2003-05-16 2004-05-07 Cyclic sulfonamides for inhibition of gamma-secretase TW200505836A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0311341A GB0311341D0 (en) 2003-05-16 2003-05-16 Therapeutic agents

Publications (1)

Publication Number Publication Date
TW200505836A true TW200505836A (en) 2005-02-16

Family

ID=9958247

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093112929A TW200505836A (en) 2003-05-16 2004-05-07 Cyclic sulfonamides for inhibition of gamma-secretase

Country Status (8)

Country Link
CN (1) CN1791585B (en)
AR (1) AR044259A1 (en)
CL (1) CL2004001015A1 (en)
DO (1) DOP2004000908A (en)
GB (1) GB0311341D0 (en)
PE (1) PE20050200A1 (en)
TW (1) TW200505836A (en)
ZA (1) ZA200508289B (en)

Also Published As

Publication number Publication date
DOP2004000908A (en) 2004-11-30
PE20050200A1 (en) 2005-03-26
CN1791585B (en) 2010-06-09
ZA200508289B (en) 2007-03-28
CL2004001015A1 (en) 2005-01-28
GB0311341D0 (en) 2003-06-25
CN1791585A (en) 2006-06-21
AR044259A1 (en) 2005-09-07

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