TW200502251A - Natriuretic compound conjugates, conjugates, and uses thereof - Google Patents

Natriuretic compound conjugates, conjugates, and uses thereof

Info

Publication number
TW200502251A
TW200502251A TW092133248A TW92133248A TW200502251A TW 200502251 A TW200502251 A TW 200502251A TW 092133248 A TW092133248 A TW 092133248A TW 92133248 A TW92133248 A TW 92133248A TW 200502251 A TW200502251 A TW 200502251A
Authority
TW
Taiwan
Prior art keywords
conjugates
disclosed
natriuretic
compounds
natriuretic compound
Prior art date
Application number
TW092133248A
Other languages
Chinese (zh)
Inventor
Kenneth D James
Balasingam Radhakrishnan
Navdeep B Malkar
Mark A Miller
Original Assignee
Nobex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp filed Critical Nobex Corp
Publication of TW200502251A publication Critical patent/TW200502251A/en

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Abstract

Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and posses an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions, particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.
TW092133248A 2003-11-26 2003-11-26 Natriuretic compound conjugates, conjugates, and uses thereof TW200502251A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42915103P 2003-11-26 2003-11-26

Publications (1)

Publication Number Publication Date
TW200502251A true TW200502251A (en) 2005-01-16

Family

ID=57798042

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092133248A TW200502251A (en) 2003-11-26 2003-11-26 Natriuretic compound conjugates, conjugates, and uses thereof

Country Status (1)

Country Link
TW (1) TW200502251A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111848776A (en) * 2020-08-31 2020-10-30 江苏璟泽生物医药有限公司 Polyethylene glycol modified rhBNP and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111848776A (en) * 2020-08-31 2020-10-30 江苏璟泽生物医药有限公司 Polyethylene glycol modified rhBNP and preparation method thereof

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