TW200502251A - Natriuretic compound conjugates, conjugates, and uses thereof - Google Patents
Natriuretic compound conjugates, conjugates, and uses thereofInfo
- Publication number
- TW200502251A TW200502251A TW092133248A TW92133248A TW200502251A TW 200502251 A TW200502251 A TW 200502251A TW 092133248 A TW092133248 A TW 092133248A TW 92133248 A TW92133248 A TW 92133248A TW 200502251 A TW200502251 A TW 200502251A
- Authority
- TW
- Taiwan
- Prior art keywords
- conjugates
- disclosed
- natriuretic
- compounds
- natriuretic compound
- Prior art date
Links
Abstract
Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and posses an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions, particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42915103P | 2003-11-26 | 2003-11-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200502251A true TW200502251A (en) | 2005-01-16 |
Family
ID=57798042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW092133248A TW200502251A (en) | 2003-11-26 | 2003-11-26 | Natriuretic compound conjugates, conjugates, and uses thereof |
Country Status (1)
Country | Link |
---|---|
TW (1) | TW200502251A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111848776A (en) * | 2020-08-31 | 2020-10-30 | 江苏璟泽生物医药有限公司 | Polyethylene glycol modified rhBNP and preparation method thereof |
-
2003
- 2003-11-26 TW TW092133248A patent/TW200502251A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111848776A (en) * | 2020-08-31 | 2020-10-30 | 江苏璟泽生物医药有限公司 | Polyethylene glycol modified rhBNP and preparation method thereof |
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