200406161 玫、發明說明 [發明所屬之技術領域] 本發明係有關於可降低香煙之主流煙中的醛類含旦 香煙過濾器。 、3里之 [先前技術] 抽煙者抽煙時吐出的主流煙中含有各種化學成分。a 等化學成分當中由曱醛所代表的醛類難以利用普通的香: 過濾器吸收並移除。因此，欲自香煙的主流煙移除醛：。 過去企圖於香煙過濾器中使用各種添加物以吸收^移 除香煙的主流煙中所含的醛類。然而，使用習知的添加： 將引起減弱於草味道的問題。 [發明内容] 本發明之一目的在提供一種香煙過濾器，該香煙過濾 器能有效地降低香煙的主流煙中的醛類含量同時抑制如养 草味道減弱的不利影響。 根據本發明的目的之香煙過濾器的特徵為包括含鹼性 胺基酸或鹼性胺基酸鹽及保溼劑的過濾器介質。 用於本發明之驗性胺基酸或驗性胺基酸鹽係選自由精 胺酸、精胺酸鹽、離胺酸、離胺酸鹽、組胺酸、組胺酸鹽、 烏胺酸、鳥胺酸鹽、瓜胺酸、瓜胺酸鹽、羥嗪及經嗪鹽所 構成的組群。用於本發明的保溼劑係選自由甘油、丙酸鈉 及乳酸鈉所構成之組群。 本發明的香煙過濾器中，所需的鹼性胺基酸或鹼性胺 基酸鹽之含量為3.5 mg或更多。 315057 200406161 I < 呈分本备明的香煙過滤器中，所需的驗性胺基酸或驗性胺 酉义鹽對保座劑之比例介於1 ·· 1及1 ·· 2之間。 [貫施方式] d、由各種觀點對添加物導入深入的研究以降低香煙的主 二，中所含之駿類的結果，發明人發現驗性胺基酸或驗性 =酸鹽為有效的添加物。本發明所用的驗性胺基酸或驗 毳月=基酸鹽係選自纟，例如，精胺酸、精胺酸鹽、離胺酸、 :胺酸鹽、組胺酸、組胺酸鹽、烏胺酸、烏胺酸鹽、瓜胺 酸、瓜胺酸鹽、經嗪及經嗪鹽所構成的組群。此等化合物 當中’精胺酸及其鹽類經認可為食物添加物。 發明人亦發現若驗性胺基酸或驗性胺基酸鹽與保座劑 結合使用將可更有效地移除香煙的主流煙中所含的酸類。 用於本發明的保漫杳丨得n白 诈&剎加、自甘油、丙酸鈉及乳酸鈉所構成 的組群。 可使用如ga酸麻纖、紙過濾材或黏漿不織布之普通過 器介質作為驗性胺基酸或鹼性胺基酸鹽及❹劑 (過濾器原料）。 a 咸相信，在本發明的香煙過濾器中，香煙的主流煙中 的酸類係藉由以下所提供的機構而降低。第一步驟，香煙 的主流煙中所含的醛類係溶於過濾器承載之保渔劑所：持 的水份。再者，使溶於水份中的駿類與過滤器承載之驗性 胺基酸或鹼性胺基酸鹽起反應而捕集於過濾器内。要注音、 保溼劑用於穩定地保持負責溶解醛類的水份。 心 本發明的香煙過滤器中，鹼性胺基酸或驗性胺基酸鹽 315057 6 200406161 的含量應為3.5mg或更多，因為含量小於3 5mg時將難以 獲得充分降低醛類的效果。 另外，本發明的香煙過濾器中，指定鹼性胺基酸或鹼 性胺基酸鹽對保渔劑的比例要落於1 ·· 1至1 : 2之間。若 上述比例並未落於上述範圍内，將難以獲得充分降低醛類 的效果。 為使過滤為介質含有驗性胺基酸或驗性胺基酸鹽及保 、座劑’可使用如噴佈、浸潰及輥輪轉印的方法。 除了鹼性胺基酸或鹼性胺基酸鹽及保溼劑之外，過濾 器介質亦可包含活性碳。 香煙濾嘴的結構可為普通型、兩段型、含三或更多段 的多段型或填塞物-間隔-填塞物型。鹼性胺基酸或鹼性胺 基酸鹽及保溼劑可含於香煙濾嘴之部分或所有區段。 本發明的香煙過濾器可為連結至香煙的菸草段作為口 含末端組件或呈煙嘴形式的過濾器。 實施例： 正丁 _所構成之8種组成分。以下的每 '取刀 以下的貝施例中，說明將指 向所要測i的酸類（獄基化合物）當中的曱酸。 在以下實施例所用之香煙主流煙中所含的醛類之測量 方法中，以高速液相層析法（HPLC)測量2,4_二硝基苯朋 (DNPH)的何生物、捕集物質。可以此方法同時測量的物質 為曱醛、乙醛、丙酮、丙烯醛'丙醛、丁烯醛、曱乙酮及 第一步驟中 笨肼（DNPH)溶於 捕集溶液係藉由將9.5] g的2，扣二硝基 L的乙腈中，接著添加5.6mL的6〇%過 315057 200406161 i - · 氯酸然後利用超純水將得到的溶液稀釋至2乙。 測量裝置的構造參照第1圖加以說明。如第i圖所示， 將DNPH捕集〉谷液12置於Drechsel型捕集哭η中。 、 Drechsel型捕集器11具有25〇mL的内部體積，DNpH捕集 . 溶液的量為100mL，無效體積為150mL。將Drechse：[型捕 集器11置於冰水浴13中冷卻。將香煙1裝在其頂端的玻 璃管14下端浸入Drechsel型捕集器π内的捕集溶液12 •t。再者’裝設玻璃管15及Cambridge墊16俾與Drechsel 型捕集器11的無效體積相連，並將自動抽煙機丨7連至 Cambridge 墊 1 6 〇 將香煙1裝到玻璃管14俾於IS〇標準所指定的標準 抽煙條件下自動地吸取香煙1。更明確地說，一支香煙以 每口兩秒吸3 5mL的煙重複進行5 8秒的時間。當主流煙發 出氣泡時，8種羰基化合物的組成分將轉變成dnph的衍 生物。該測量使用兩支香煙。 _ 以HPLC測量由此形成的衍生物。第一步驟中，過淚 捕集溶液，接著利用Trizma Base溶液（4mL的捕集溶液： 6mL的Trizma Base溶液）稀釋濾出的捕集溶液。然後，以 HPLC測量稀釋溶液。HPLC的測量條件如下： 管柱：HP LiChrospher 100ΙΙΡΜ8(5μ)250 X 4 mm ; 防護管柱：HP LiChrosphei· l〇〇RP_i8(5p)4 χ 4 mm ; 管柱溫度：3 0 °C ; 偵測波長·· DAD 356nm ; 注射量：2 0 μί ; 315057 200406161 私動相·含3個相的梯度 (溶液AJ含3〇%乙腈、1〇%四氫11夫喝及1%異丙醇（IPA)之 超純水溶液；溶液B :含65%乙腈、1%四氫咲喊及1%異 丙醇之超純水溶液；溶液C ·· 1 〇〇0/。乙腈）。 參照第2圖所示的剖面圖示說明用作樣品的香煙結 構。如第p圖所示，香煙含有利用捲煙紙22捲包切細的菸 草21的於草段20，以及利用成形紙32捲包過濾器3丨的 過濾器段30。用水松紙40將過濾器段3〇連至菸草段2〇。 在使用添加鹼性胺基酸或鹼性胺基酸鹽及保溼劑的試 驗過濾器製備的香煙時，自市面上可購得的心^卜焦油香煙 切下醋酸酯過濾器而取出煙草段5將該煙草段連到試驗過 濾器以提供樣品。使用喷霧器將鹼性胺基酸或鹼性胺基酸 鹽及保溼劑加至試驗過濾器。 試驗1 : 製備作為基礎過濾器之25mm-長的醋酸酯過濾器。另 外’使基礎過濾器包含6.5mg的水以製備對照用的試驗過 濾斋。再者，使基礎過濾器包含6.5mg的水及3.5 mg的添 加物以製備試驗過濾器。該添加物係選自由L_精胺酸、精 榖胺酸（arginine glutamate)、甲酸醯肼（hydrazide formate)、氨、乙醯胺及尿素所構成的組群，歸類為含氮 的驗性物質。 各過濾器皆連到上述的菸草段以製備香煙樣品，由上 述測量方法測量每支香煙主流煙中的曱醛輸送量（μβ/香 煙）^第3圖為顯示結果的圖形。與基礎過濾器僅包含水份 9 3]5057 200406161 l * 的情形相比，第3圖顯然能支持驗性胺基酸中的L_精胺酸 及鹼性胺基酸鹽中的精穀胺酸對於降低甲醛的輸送量特別 有效的結果。 意外地發現到，為了降低甲醛的輸送量，過濾器中^ 精胺酸或精穀胺酸的量較佳為3.5mg或更多。 試驗2 : 使基礎過濾器包含L-精胺酸及不同的水量。將水含量 •不相同的過濾器連至上述的於草段以製備香煙樣品，以 上述測量方法測量每支香煙主流煙中的曱醛輸送量（吨/香 煙）。第4圖為顯示結果的圖形。由第4圖顯然可見，在過 渡器含3.5mg L-精胺酸的情形中，若過濾器中的水份為 5mg或更多則可有效地降低主流煙中的曱酸。 ' 試驗3 : 使基礎過濾器包含L-精胺酸及用作保溼劑之甘油以 檢查過濾杰中增加的水量。將L_精胺酸含量設定於3 $ • g、7.0mg或l〇.5mg。將甘油含量設定於18叫或叫。 第5圖為顯示結果的圖形。第5圖顯然能支持過渡器所保 持的水份含量會隨著保溼劑，亦即，甘油，的用量增加而 增加的結果。 試驗4 : 使土礎過濾态僅含有3 5mg的L•精胺酸以製備不含保 溼劑之對照用的試驗過濾器。另外’使基礎過濾器Z含 3.5mg的L-精胺酸及保溼劑以製備試驗過濾器。保溼劑： 逛自由甘〉由、木糖醇、泛酸鈉、2_吡咯烷酮羧酸鈉㈣八 3】5057 10 200406161 納）、乳酸納、丙酸納、DL_賴果酸鈉、卜甘露糖及氣化妈 所構成之組群。將各試驗過濾器連至上述菸草段以製備香 菸f品，以上述測量方法測量每支香煙主流煙中的曱醛2 送量—/香煙）。第6圖為顯示結果的圖形。由第6圖顯然 可見，與使基礎過濾'器僅包含L•精胺酸的情形相比，用作 保溼』的甘油、礼酸鈉及丙酸鈉能有效地降低曱醛的輸送 量。就過濾器的製造過程而言’此等保溼劑皆係適宜的。 試驗5 : 製備不同的試驗過濾器，其中基礎過濾器包含3. 的L精g义及不同|之作為保漫劑的乳酸鈉。將乳酸納對 L-精胺酸的比例設定於1 : 1、：[ : 2或i : 3。 使各試驗過濾器連至上述的菸草段以製備香煙樣品， 以上返測量方法測量#支香、煙主流煙中的曱醛輸送量⑽ 曰煙）°第7圖為顯不結果的圖形。由第7圖能支持使基礎 過濾器包含比例為U 1:2之匕精胺酸與乳酸時，可 有效地降低主流煙中的曱醛輸送量的結果。 本I明的香煙過濾杰可有效地降低香煙的主流煙中所 含的甲醛含量。 [圖式簡單說明] 第1圖概略地顯示用於測量本發明之實施例的香煙主 流煙中所含的曱醛之裝置的結構； 第2圖為顯示本發明之實施例中所用的香煙之結構的 剖面圖示； 第3圖為顯示視添加至香煙過濾器的鹼性物質類型而 315057 200406161 定之甲醛運送圖形； 第4圖為顯示與L -精胺酸一起添加至香煙過渡、器的水 量與曱醛運送之間的關係圖； 第5圖為顯示與L-精胺酸一起添加至香煙過渡器的甘 油用量與香煙過濾器中增加的水量之間的關係圖； 第6圖為顯示視與L-精胺酸一起添加至香煙過濾器的 保溼劑類型而定之曱醛運送圖；以及 > 第7圖為顯示添加至香煙過濾器的L-精胺酸對甘油之 比例與曱醛運送之間的關係圖。 1 香煙 11 Drechsel型捕集器 12 捕集溶液 13 冰水浴 14 玻璃管 15 玻璃管 16 Cambridge 墊 17 自動抽煙機 20 菸草段 21 切細的於草 Ϊ2 捲煙紙 30 過濾器段 3 1 過濾器 32 成形紙 40 水松紙 315057200406161 Description of the invention [Technical field to which the invention belongs] The present invention relates to an aldehyde-containing cigarette filter that can reduce the mainstream smoke of cigarettes. , 3 miles [prior art] The mainstream smoke that smokers emit when they smoke contains various chemical components. The aldehydes represented by amidaldehyde among other chemical ingredients are difficult to be absorbed and removed by ordinary fragrances: filters. Therefore, it is desired to remove aldehydes from mainstream cigarettes. In the past, attempts have been made to use various additives in cigarette filters to absorb and remove aldehydes contained in mainstream cigarettes. However, the use of conventional additions: will cause a problem of weakening the taste of grass. [Disclosure of the Invention] An object of the present invention is to provide a cigarette filter which can effectively reduce the aldehyde content in mainstream cigarettes of cigarettes while suppressing adverse effects such as weakening the taste of grass cultivation. A cigarette filter according to the object of the present invention is characterized by including a filter medium containing a basic amino acid or a basic amino acid salt and a humectant. The test amino acid or test amino acid used in the present invention is selected from the group consisting of arginine, spermine, lysine, lysine, histamine, histamine, ursine , Ornithine, citrulline, citrulline, hydroxyzine, and transazine The humectant used in the present invention is selected from the group consisting of glycerin, sodium propionate and sodium lactate. In the cigarette filter of the present invention, the required content of the basic amino acid or basic amino acid salt is 3.5 mg or more. 315057 200406161 I < The presently specified cigarette filter, the ratio of the required amino acid or amino acid salt to the retainer is between 1 ·· 1 and 1 ·· 2 . [Performance method] d. Introduced in-depth research on additives from various viewpoints to reduce the results of the main ingredients contained in cigarettes. The inventors found that the amino acid or the acidity = acid salt is effective. Additives. The test amino acid or test compound used in the present invention is selected from the group consisting of arginine, arginine, lysine, amine, histamine, histamine , Uramine, uramine, citrulline, citrulline, triazine and triazine salt. Among these compounds, ' arginine and its salts are recognized as food additives. The inventors have also discovered that the use of an amino acid or an amino acid salt in combination with a retainer will more effectively remove the acids contained in the mainstream smoke of a cigarette. The manganese used in the present invention is a group consisting of n-white & saccharin, glycerin, sodium propionate and sodium lactate. Ordinary pass media such as ga acid hemp fiber, paper filter material or pulp non-woven fabric can be used as the test amino acid or basic amino acid salt and tincture (filter material). a. It is believed that in the cigarette filter of the present invention, the acid in mainstream cigarettes is reduced by the mechanism provided below. In the first step, the aldehydes contained in the mainstream cigarettes of the cigarette are dissolved in the moisture-retaining agent held by the filter: the moisture content. In addition, the water-soluble species of warfare react with the amino acid or basic amino acid salt carried by the filter to be trapped in the filter. To note, humectants are used to stably maintain the moisture responsible for dissolving aldehydes. In the cigarette filter of the present invention, the content of the basic amino acid or the test amino acid salt 315057 6 200406161 should be 3.5 mg or more, because when the content is less than 35 mg, it is difficult to obtain the effect of sufficiently reducing aldehydes. In addition, in the cigarette filter of the present invention, the ratio of the specified basic amino acid or basic amino acid salt to the fishing agent must fall between 1 ·· 1 and 1: 2. If the above ratio does not fall within the above range, it will be difficult to obtain a sufficient effect of reducing aldehydes. In order to filter the media to contain an amino acid or an amino acid and a base agent, a method such as spraying, dipping, and roller transfer can be used. In addition to basic amino acids or basic amino salts and humectants, the filter media may also contain activated carbon. The structure of the cigarette filter may be a common type, a two-stage type, a multi-stage type containing three or more sections, or a stuffer-spacer-stuffer type. The basic amino acid or basic amino acid salt and humectant may be contained in part or all of the segments of the cigarette filter. The cigarette filter of the present invention may be a filter attached to a tobacco segment of a cigarette as an oral end assembly or in the form of a mouthpiece. Examples: 8 kinds of constituents composed of n. In each of the following examples of taking the knife, the explanation will be directed to the osmic acid among the acids (prisyl compounds) to be measured. In the method for measuring the aldehydes contained in the mainstream cigarettes of cigarettes used in the following examples, high-speed liquid chromatography (HPLC) was used to measure the 2,4-dinitrobenzene (DNPH) organisms and capture substances . The substances that can be measured simultaneously by this method are acetaldehyde, acetaldehyde, acetone, acrolein 'propanal, butenal, acetophenone, and hydrazine (DNPH) in the first step in the capture solution. g of 2, acetonitrile with dinitro L, and then added 5.6 mL of 60% over 315057 200406161 i-· chloric acid, and then the resulting solution was diluted to 2 ethyl with ultrapure water. The structure of the measuring device will be described with reference to FIG. 1. As shown in Fig. I, DNPH trapping> Valley 12 was placed in a Drechsel-type trap. The Drechsel-type trap 11 has an internal volume of 25 mL and DNpH traps. The amount of solution is 100 mL and the ineffective volume is 150 mL. Drechse: [type trap 11 was placed in an ice-water bath 13 to cool. The lower end of a glass tube 14 with a cigarette 1 mounted on the top thereof was immersed in a capture solution 12 t in a Drechsel-type trap π. Furthermore, 'the glass tube 15 and the Cambridge pad 16' are connected to the ineffective volume of the Drechsel-type trap 11, and the automatic smoking machine 丨 7 is connected to the Cambridge pad 1 6 〇 the cigarette 1 is mounted on the glass tube 14 and the IS 〇 Cigarettes are automatically smoked under standard smoking conditions specified by the standard. More specifically, a cigarette is smoked at a rate of 35 mL for two seconds per mouth for 5 8 seconds. When the mainstream smoke emits bubbles, the constituents of the eight carbonyl compounds will be converted into dnph derivatives. This measurement uses two cigarettes. _ The derivative formed is measured by HPLC. In the first step, the tear trapping solution was passed, and then the filtered trapping solution was diluted with Trizma Base solution (4 mL of trapping solution: 6 mL of Trizma Base solution). Then, the diluted solution was measured by HPLC. The measurement conditions of HPLC are as follows: Column: HP LiChrospher 100 ΙΡΜ8 (5 μ) 250 X 4 mm; Protective Column: HP LiChrosphei · 100RP_i8 (5p) 4 χ 4 mm; Column temperature: 30 ° C; Detection Wavelength · DAD 356nm; Injection volume: 2 0 μί; 315057 200406161 Private phase · Gradient with 3 phases (Solution AJ contains 30% acetonitrile, 10% tetrahydro 11 fu and 1% isopropyl alcohol (IPA ); Ultra-pure aqueous solution; Solution B: ultra-pure aqueous solution containing 65% acetonitrile, 1% tetrahydrofluorene, and 1% isopropanol; solution C · 1000 (acetonitrile). The structure of a cigarette used as a sample will be described with reference to the cross-sectional diagram shown in FIG. As shown in Fig. P, the cigarette contains a straw section 20 wrapped with a cigarette 21 wrapped in cigarette paper 22, and a filter section 30 wrapped with a filter 32 in a formed paper 32. The filter section 30 is connected to the tobacco section 20 with a tap paper 40. When using a cigarette prepared with a test filter containing a basic amino acid or a basic amino acid salt and a humectant, a commercially available heart tar cigarette is cut out of the acetate filter to remove the tobacco segment 5 Connect the tobacco segment to a test filter to provide a sample. Add a basic amino acid or basic amino acid salt and humectant to the test filter using a sprayer. Test 1: A 25 mm-length acetate filter was prepared as a base filter. In addition, the base filter was made to contain 6.5 mg of water to prepare a test filter for control. Furthermore, the base filter was made to contain 6.5 mg of water and 3.5 mg of an additive to prepare a test filter. The additive is selected from the group consisting of L-arginine, arginine glutamate, hydrazide formate, ammonia, acetamide, and urea, and is classified as nitrogen-containing. substance. Each filter was connected to the above tobacco section to prepare a cigarette sample, and the amount of formaldehyde transported in the mainstream smoke of each cigarette (μβ / smoke) was measured by the measurement method described above. Figure 3 is a graph showing the results. Compared with the case where the basic filter contains only water 9 3] 5057 200406161 l *, Figure 3 clearly supports L-arginine in amines and seroglutamine in basic amines Acid is particularly effective in reducing the amount of formaldehyde delivered. It has been unexpectedly found that in order to reduce the amount of formaldehyde delivered, the amount of arginine or arginine in the filter is preferably 3.5 mg or more. Test 2: The base filter was made up of L-arginine and different amounts of water. A different water content filter was connected to the above-mentioned grass section to prepare a cigarette sample, and the above-mentioned measurement method was used to measure the formaldehyde transport amount (tonnes / smoke) in the mainstream smoke of each cigarette. Figure 4 is a graph showing the results. It is clear from Fig. 4 that in the case where the transit device contains 3.5 mg of L-arginine, if the water content in the filter is 5 mg or more, the arsenic acid in the mainstream smoke can be effectively reduced. 'Test 3: The base filter was made to contain L-arginine and glycerin as a humectant to check the amount of water added to the filter. Set the L-arginine content to 3 $ • g, 7.0 mg, or 10.5 mg. Set the glycerin content to 18 or. Figure 5 is a graph showing the results. Figure 5 clearly supports the result that the water content held by the transition device will increase as the amount of humectant, that is, glycerol, increases. Test 4: A soil filter containing only 35 mg of L-arginine was used to prepare a test filter for a control containing no moisture-retaining agent. In addition, the base filter Z was made to contain 3.5 mg of L-arginine and a humectant to prepare a test filter. Humectants: Freedom> Yan, Xylitol, Sodium Pantothenate, Sodium 2-Pyrrolidone Carboxylate ㈣3] 5057 10 200406161 Na), Sodium Lactate, Sodium Propionate, DL_Sodium Lysate, Bumannose And the group of gasification moms. Each test filter was connected to the above tobacco section to prepare a cigarette f product, and the above-mentioned measurement method was used to measure the amount of formaldehyde 2 in each mainstream cigarette (/ cigarette). Figure 6 is a graph showing the results. It is clear from Fig. 6 that glycerin, sodium lactate and sodium propionate used as moisturizers can effectively reduce the amount of formaldehyde transported compared to the case where the basic filter contains only L • arginine. These humectants are suitable in terms of the manufacturing process of the filter. Test 5: Different test filters were prepared, wherein the base filter contained 3. L, and different | of sodium lactate as a diffuser. Set the ratio of sodium lactate to L-arginine at 1: 1,: [: 2, or i: 3. Each test filter was connected to the above-mentioned tobacco segment to prepare a cigarette sample, and the above measurement method was used to measure the amount of acetaldehyde transported in the #scented incense and mainstream tobacco smoke (referred to as smoke). Figure 7 is a graph showing the results. Fig. 7 can support the result that when the base filter contains arginine and lactic acid in a ratio of U 1: 2, it can effectively reduce the amount of formaldehyde transported in mainstream smoke. The cigarette filter of the present invention can effectively reduce the formaldehyde content in mainstream cigarettes. [Brief Description of the Drawings] Fig. 1 schematically shows the structure of a device for measuring the formaldehyde contained in the mainstream cigarette of the embodiment of the present invention. Fig. 2 is a diagram showing the structure of the cigarette used in the embodiment of the present invention. Sectional diagram of the structure; Figure 3 shows the formaldehyde transport pattern according to the type of alkaline substance added to the cigarette filter 315057 200406161; Figure 4 shows the amount of water added to the cigarette transition device with L-arginine Figure 5 shows the relationship between acetaldehyde transport; Figure 5 shows the relationship between the amount of glycerol added to the cigarette transitioner with L-arginine and the amount of water added to the cigarette filter; Figure 6 shows the display Aldehyde transport map depending on the type of humectant added to the cigarette filter with L-arginine; and Figure 7 shows the ratio of L-arginine to glycerol and aldehyde added to the cigarette filter Diagram of relationships between shipments. 1 Cigarette 11 Drechsel-type trap 12 Trapping solution 13 Ice water bath 14 Glass tube 15 Glass tube 16 Cambridge mat 17 Automatic smoking machine 20 Tobacco section 21 Shredded grass straw 2 Cigarette paper 30 Filter section 3 1 Filter 32 formed Paper 40 Tip Paper 315057