TR2024000684A2

TR2024000684A2 - A FORMULATION FOR WOUNDS AND SKIN DISORDERS

Info

Publication number: TR2024000684A2
Application number: TR2024/000684
Authority: TR
Inventors: Ucar İhsan
Original assignee: Avi̇nova İlaç Gida Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇; İhsan Uçar; Ni̇gar Hatunoğlu; Ni̇zametti̇n Çi̇çek
Filing date: 2024-01-19
Publication date: 2024-03-21

Abstract

Buluş, ağız içinde oluşan yaralarda, cilt üzerinde oluşan yara, kaşıntı ve döküntü gibi rahatsızlıklarda ve cilt yenileyici olarak kullanılan ve bitkisel içerikli olması sayesinde ağız ve ciltte yaraların iyileşme sürecini hızlandırarak enfeksiyon olasılığını azaltan ve cildin yenilenmesine katkı sağlayan bir formülasyon ile ilgilidir.The invention is related to a formulation that is used in wounds in the mouth, skin conditions such as wounds, itching and rashes, and as a skin regenerator, and thanks to its herbal content, it accelerates the healing process of wounds in the mouth and skin, reduces the possibility of infection and contributes to the regeneration of the skin.

Description

TARIFNAME YARALAR VE CILT RAHATSIZLIKLARI içiN BIR FORMÜLASYON Teknik Alan Bulus, agiz içinde olusan yaralarda, cilt üzerinde olusan yara, kasinti ve döküntü gibi rahatsizliklarda ve cilt yenileyici olarak kullanilan bir formülasyon ile ilgilidir. Bulus özellikle, bitkisel içerikli olmasi sayesinde agiz ve ciltte yaralarin iyilesme sürecini hizlandirarak enfeksiyon olasiligini azaltan ve cildin yenilenmesine katki saglayan bir formülasyon ile ilgilidir. Teknigin Bilinen Durumu Yara, hücre ve dokularin yapisal ve islevsel özelliklerinin iç veya dis etkenler nedeniyle bozulmasi olarak tanimlanir. Yaralanmaya yol açan birçok faktör bulunmaktadir. Batici, kesici, delici aletler ile ciltte fiziksel yolla yara olusmaktadir. Asiri sicak (yanik, haslanma) veya asiri soguk (donuk) yara çesitleri olusmasina neden olabilmektedir. Ultraviyole isik veya radyasyon, asit veya alkali maddeler de kimyasal yolla cilt üzerinde yara olusturabilmektedir. Öte yandan, vücudun belirli bölgelerin uzun süre basiya maruz kalmasi da yara sebebi olabilmektedir. Basi yaralari çesitli nedenlerle uzun süre yataga, iskemleye bagli olarak yasayan hastalarda yaygin olarak görülmekte ve basi olusan belirli bölgelerde giderek derinlesen hatta kemige kadar ulasan yaralara yol açmaktadir. Ayrica seker hastalarinin ayaklarinda olusan yaralar Yaralarin iyilesme zamani yara çesidine göre degismekte ve akut, kronik yara veya basi yaralarinin tedavisi farkli sekillerde yapilmaktadir. Ancak bu tedavilerin tamami, uzun süreli ve hasta açisindan zahmetli olmaktadir. Yara yüzeyinde enfeksiyon olusumu da yaralar açisindan beklenen risklerin basinda yer almaktadir. Bunlarin yani sira, yaranin temizlenmesi için kullanilan alkol ve tentürdiyot gibi maddeler sadece mikroplara degil, yaranin iyilesmesi için gerekli hücrelere de zarar vermektedir. Ayrica sürülen alkol içerikli maddeler, yara bölgesini tahris ederek alerjik rahatsizliklara neden olabilmektedir. Bu nedenle teknigin bilinen durumunda yaralarin iyilesme sürecine katki saglayan bitkisel birformülasyona ihtiyaç duyulmustur. Literatürde yapilan arastirmada teknigin bilinen durumuna bir örnek olarak iyilestirme kompozisyonu ile ilgilidir. Söz konusu kompozisyon; agirlikça : %0.2 - %0.8 Stearik Asit, %1 -%3 Setil Alkol, %.2-%8 Balmumu, %2-%8 Aynisafa (Calendula Officinalis) Ekstrakti, Distile Su (%100'e tamamlayacak kadar), %0.2-%0.8 Metil Alfa Tokoferol Asetattan olusmaktadir. Kompozisyon içeriginde alkol mevcuttur. Bu da hücrelerin zarar görmesine neden olan bir içerik olusturmaktadir. gösterilebilir. Bahsi geçen doküman, deri hastaliklarinin tedavisinde kullanilmak üzere bir yara örtüsü ile ilgilidir. Söz konusu yara örtüsü özellikle melanomanin tedavisinde kullanilmak üzere, fotodinamik terapi (PDT) ve hedefli ilaç sistemlerini içeren kombine bir tedavi saglayan polivinil alkol (PVA), polilaktik (PLA), poliglikolik asit (PGA), poli laktik -ko- glikolik asit (PLGA), polikaprolakton (PCL), poliüretan (PU), polihidroksi bütirat (PHB) grubundan seçilen bir polimer veya bunlarin kombinasyonunu içeren malzemelerden mamul, nanolifli, fotodinamik terapi ajani (grafen kuantum noktalari (GQDs) ve kemoterapik ilaç (doksorubisin) ihtiva eden hidrojel (kollajen) içermektedir. Söz konusu yara örtüsü, kanser hastalarina özel bir formülasyona sahip oldugundan genel kullanima uygun degildir. Sonuç olarak yukaridaki problemlerin varligi ve mevcut çözümlerin yetersizligi, ilgili teknik alanda bir gelistirme yapmayi zorunlu kilmistir. Bulusun Amaci Mevcut bulus yukarida bahsedilen dezavantajlari ortadan kaldiran ve ilgili teknik alana yeni avantajlar getiren yaralar ve cilt rahatsizliklari için bir formülasyon ile ilgilidir. Bulusun ana amaci, bitkisel içerikli olmasi sayesinde agiz ve ciltte yaralarin iyilesme sürecini hizlandirarak enfeksiyon olasiligini azaltan birformülasyon ortaya koymaktir. Bulusun amaci, alkol ve tentürdiyot gibi cilde zarar verici maddeler içermemesi sayesinde cildin yenilenmesine katki saglayan bir formülasyon ortaya koymaktir. Bulusun Detayli Açiklamasi Bu detayli açiklamada, bulus konusu formülasyonun tercih edilen alternatifleri, sadece konunun daha iyi anlasilmasina yönelik olarak ve hiçbir sinirlayici etki olusturmayacak sekilde açiklanmaktadir. Bulus, agiz içinde olusan yaralarda, cilt üzerinde olusan yara, kasinti ve döküntü gibi rahatsizliklarda ve cilt yenileyici olarak kullanilan ve damar otu, kapya biberi, sisi biberi ve su içeren bir formülasyondur. Tablo 1'de bulus konusu formülasyonun içerigi ve oranlari verilmektedir. Tablo 1: Formülasyon içerigi ve kullanim oranlari Içerik Agirlikça Agirlikça Tercih Kullanilabilen Edilen Miktar (%) Miktar Damar otu 0,5-1 0,8 Kapya biberi 47-50 47,5 Sili biberi 1,5-2 1,7 Su 50-55 50 Damar otu özellikle antibakteriyel ve anti imflamatuar oldugundan ciIt sagligi için önemli bir bitkidir. Bu nedenle ilaç sektöründe oldugu kadar, kozmetik sektöründe de yaygin olarak kullanilmaktadir. Damar otu, hücrelerin yenilenmesine yardimci olarak gençlestirici kremler ve kirisiklik karsiti kürler için siklikla kullanilmaktadir. Kapya biberi olarak da bilinen kirmizi biber, kalojen ve anti oksidan açisinda zengin bir besindir. Ancak bu besinin yenilerek tüketilmesi durumunda yeterli degere ulasilamayacagi için belirli bir yöntemle üretilip uygulamaya hazir hale getirilmesi gerekmektedir. Sili biberi de cildin saglikli ve pürüzsüz bir görünüme kavusmasina yardimci olan bir bitkidir. Antienflamatuar özelligiyle sedef, egzama ve gül hastaligi gibi cilt sorunlarinin tedavisinde etkilidir. Tadi oldukça aci olan Sili biberinin besin olarak tüketilmesinde kimi kisiler zorlanabilmektedir. Kapya biberinde oldugu gibi Sili biberinde de yeterli degere beslenme yoluyla ulasilmasi mümkün olmamaktadir. Bulusa konu formülasyonun üretim yöntemi su sekildedir; a) Kapya biberinin saplarinin çikarilarak, biber çekirdegi içinde kalacak sekilde mikserden geçirilmesi ve mikserden geçirilen kapya biberlerine su ilave edilerek kaynama noktasina kadar isitilmasi ve ardindan dinlenme islemine alinmasi, b) Sili biberinin, kapya biberi gibi saplarinin çikarilarak çekirdekleri içinde kalacak sekilde mikserden geçirilmesi ve mikserden geçirilen Sili biberlerine su ilave edilerek kaynama noktasina kadar isitilmasi ve ardindan dinlenme islemine alinmasi, 0) Damar otunun mikserden geçirilmesi ve mikserden geçirilen damar otuna su ilave edilerek kaynatilmasi ve ardindan dinlenme islemine alinmasi, d) Dinlenme süreçlerinin ardindan kapya biberi, Sili biberi ve damar otu sivilarinin birbirine karistirilmasi ve karisim içerisine su eklenmesi, e) Elde edilen karisimin bir imbikten geçirilerek damitilmasi ve kullanima hazir hale getirilmesi. Bahsedilen (a) ve (b) islem adiminda kapya biberi ve Sili biberinin kaynama noktasina kadar isitilmasi ile kati maddenin dibe çökmesi beklenmektedir. Kaynama noktasinda dibe çöken kapya biberi ve Sili biberi sivisi, ates üzerinden alinarak dinlenme sürecine geçilir. Dinlenme süreci ortalama 10-14 saattir. Bahsedilen (c) islem adiminda damar otu, kaynama noktasindan sonra tercihen 5 dakika daha kaynatilir ve dinlenme sürecine alinir. Dinlenme süreci ortalama 10-14 Bahsedilen (d) islem adiminda elde edilen karisim, turuncuya yakin bir renkte ve meyve suyu kivamindadir. Bahsedilen (e) islem adiminda elde edilen kullanima hazir haldeki ürün, su gibi seffaf ve sivi formdadir. Bulusa konu formülasyon, cilt yüzeyindeki yaralara spreyle uygulanabilir veya agiz içi yaralari için gargara sekilde kullanilir. TR TR TR TRDESCRIPTION A FORMULATION FOR WOUNDS AND SKIN DISEASES Technical Field The invention relates to a formulation used in wounds formed in the mouth, in discomforts such as wounds, itching and rashes formed on the skin and as a skin rejuvenator. The invention relates to a formulation that, in particular, accelerates the healing process of wounds in the mouth and skin thanks to its herbal content, reduces the possibility of infection and contributes to the rejuvenation of the skin. Known State of the Art A wound is defined as the deterioration of the structural and functional properties of cells and tissues due to internal or external factors. There are many factors that cause wounds. Wounds are formed on the skin by physical means with pricking, cutting and piercing tools. Excessive heat (burn, scald) or excessive cold (frostbite) can cause wound types. Ultraviolet light or radiation, acid or alkali substances can also cause wounds on the skin by chemical means. On the other hand, prolonged exposure of certain parts of the body to pressure can also be a cause of wounds. Pressure sores are commonly seen in patients who are confined to a bed or chair for a long time for various reasons, and cause wounds that gradually deepen and even reach the bone in certain areas where pressure occurs. Also, wounds on the feet of diabetic patients The healing time of wounds varies according to the type of wound, and acute, chronic wounds or pressure sores are treated in different ways. However, all of these treatments are long-term and troublesome for the patient. Infection formation on the wound surface is also one of the expected risks for wounds. In addition, substances such as alcohol and tincture of iodine used to clean the wound damage not only the microbes but also the cells necessary for the wound to heal. In addition, substances containing alcohol can irritate the wound area and cause allergic reactions. Therefore, in the state of the art, a herbal formulation that contributes to the healing process of wounds has been needed. In the research conducted in the literature, an example of the state of the art is related to the healing composition. The composition in question consists of; by weight: 0.2% - 0.8% Stearic Acid, 1% - 3% Cetyl Alcohol, .2% - 8% Beeswax, 2% - 8% Calendula Officinalis Extract, Distilled Water (enough to complete to 100%), 0.2% - 0.8% Methyl Alpha Tocopherol Acetate. The composition contains alcohol. This creates a content that causes damage to cells. can be shown. The document in question is related to a wound dressing to be used in the treatment of skin diseases. The said wound dressing is a combined treatment that includes photodynamic therapy (PDT) and targeted drug systems, especially for use in the treatment of melanoma, and is made of materials such as a polymer selected from the group of polyvinyl alcohol (PVA), polylactic (PLA), polyglycolic acid (PGA), poly lactic-co-glycolic acid (PLGA), polycaprolactone (PCL), polyurethane (PU), polyhydroxy butyrate (PHB) or a combination thereof, and is nanofibrous, and contains hydrogel (collagen) containing photodynamic therapy agent (graphene quantum dots (GQDs) and chemotherapy drug (doxorubicin). The said wound dressing is not suitable for general use since it has a special formulation for cancer patients. As a result, the existence of the above problems and the inadequacy of the existing solutions have necessitated a development in the relevant technical field. Purpose of the Invention The present invention eliminates the above-mentioned disadvantages and provides a solution that is suitable for the relevant technical field. It is related to a formulation for wounds and skin disorders that brings new advantages. The main purpose of the invention is to present a formulation that reduces the possibility of infection by accelerating the healing process of wounds in the mouth and skin thanks to its herbal content. The purpose of the invention is to present a formulation that contributes to the renewal of the skin thanks to the fact that it does not contain substances that harm the skin such as alcohol and tincture of iodine. Detailed Description of the Invention In this detailed description, the preferred alternatives of the formulation in question are explained only for a better understanding of the subject and in a way that will not create any limiting effect. The invention is a formulation containing damar herb, capia pepper, sisi pepper and water used in wounds in the mouth, wounds, itching and rashes on the skin and as a skin renewer. Table 1 provides the content and proportions of the formulation in question. Table 1: Formulation content and usage rates Content Weight Weight Preference Usable Amount (%) Amount Damar herb 0.5-1 0.8 Capia pepper 47-50 47.5 Chili pepper 1.5-2 1.7 Water 50-55 50 Damar herb is an important plant for skin health, especially because it is antibacterial and anti-inflammatory. For this reason, it is widely used in the cosmetics sector as well as in the pharmaceutical sector. Damar herb is frequently used for rejuvenating creams and anti-wrinkle treatments, helping cell renewal. Red pepper, also known as capia pepper, is a food rich in collagen and antioxidants. However, since sufficient value cannot be reached when this food is consumed by eating, it must be produced with a certain method and made ready for application. Sili pepper is also a plant that helps the skin to have a healthy and smooth appearance. It is effective in the treatment of skin problems such as psoriasis, eczema and rosacea with its anti-inflammatory properties. Some people may have difficulty consuming Sili pepper as food, as it tastes quite hot. As with capia pepper, it is not possible to reach sufficient value in Sili pepper through nutrition. The production method of the formulation in question is as follows; a) By removing the stems of the capia pepper, putting it through the mixer while leaving the pepper seeds inside, and adding water to the capia peppers put through the mixer, heating it to the boiling point and then letting it rest, b) By removing the stems of the sili peppers like the capia peppers, putting it through the mixer while leaving the seeds inside, adding water to the sili peppers put through the mixer, heating it to the boiling point and then letting it rest, 0) By passing the damar herb through the mixer, adding water to the damar herb put through the mixer, boiling it and then letting it rest, d) After the resting processes, mixing the liquids of the capia pepper, sili pepper and damar herb together and adding water to the mixture, e) Distilling the resulting mixture through a still and making it ready for use. In the mentioned (a) and (b) process steps, the solid material is expected to settle to the bottom by heating the capia pepper and Sili pepper to the boiling point. The capia pepper and Sili pepper liquid that settles to the bottom at the boiling point is removed from the fire and the resting process is started. The resting process is 10-14 hours on average. In the mentioned (c) process step, the damar herb is boiled for preferably 5 more minutes after the boiling point and is taken to the resting process. The resting process is 10-14 hours on average. The mixture obtained in the mentioned (d) process step is close to orange in color and has the consistency of fruit juice. The ready-to-use product obtained in the mentioned (e) process step is transparent like water and in liquid form. The formulation in question can be applied to wounds on the skin surface by spraying or used as a gargle for wounds in the mouth. TR TR TR TR

Claims

STEMS

. It is a formulation used for wounds in the mouth, skin conditions such as wounds, itching and rashes, and as a skin regenerator. Its feature is; - It contains vein herb, capia pepper, Chili pepper and water.

. It is a formulation in accordance with claim 1 and its feature is; It contains 0.5-1% by weight vein herb, 47-50% by weight capia pepper, 1.5-2% by weight Chile pepper, and 50-55% water by weight.

. It is a formulation production method used for wounds in the mouth, skin conditions such as wounds, itching and rashes, and as a skin regenerator. Its feature is; a) Removing the stems of the capia pepper and passing them through the mixer so that the pepper seeds remain inside, adding water to the capia peppers passed through the mixer and heating them to the boiling point, and then letting them rest, b) Removing the stems of the capia pepper, like the capia pepper, and passing them through the mixer so that the seeds remain inside and removing them from the mixer. Adding water to the processed Chilean peppers and heating them to the boiling point and then taking them to the resting process, 0) Passing the veins through the mixer and boiling them by adding water to the veins passed through the mixer and then taking them to the resting process, d) After the resting periods, capia peppers, Chilean peppers and vetiver plants are put into the resting process. It includes the process steps of mixing the liquids together and adding water to the mixture, e) Distilling the resulting mixture through a still and making it ready for use.

. It is a formulation production method in accordance with claim 3, and its feature is; The mentioned process steps (a) and (b) involve heating the capia pepper and Chile pepper to the boiling point and then letting them rest for 10-14 hours.

5. It is a formulation production method in accordance with claim 3, and its feature is; The mentioned process step (c) includes the process step of boiling the vein herb for another 5 minutes and then letting it rest for 10-14 hours.