TR2022020810T2 - A SYSTEM WHERE SHAPE MEMORY ALLOY IS USED IN DRUG RELEASE - Google Patents
A SYSTEM WHERE SHAPE MEMORY ALLOY IS USED IN DRUG RELEASEInfo
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- TR2022020810T2 TR2022020810T2 TR2022/020810 TR2022020810T2 TR 2022020810 T2 TR2022020810 T2 TR 2022020810T2 TR 2022/020810 TR2022/020810 TR 2022/020810 TR 2022020810 T2 TR2022020810 T2 TR 2022020810T2
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- tissue
- drug
- organ
- drug delivery
- shape memory
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- 239000003814 drug Substances 0.000 title claims description 23
- 229940079593 drug Drugs 0.000 title claims description 23
- 229910001285 shape-memory alloy Inorganic materials 0.000 title claims description 23
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- KHYBPSFKEHXSLX-UHFFFAOYSA-N iminotitanium Chemical compound [Ti]=N KHYBPSFKEHXSLX-UHFFFAOYSA-N 0.000 claims 5
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Abstract
Buluşun yenilikçi yönü daha öncesinde de belirtildiği üzere spesifik olarak hedef organ veya dokuya yönelik etken maddeyi taşıyan bir ilaç taşıma sistemi üzerinedir. Buluş esas olarak ilaç taşıma sistemini oluşturan şekil hafızalı bileşenin biyouyumluluğunu arttırmak için kaplanması ve kaplama malzemesi bünyesine alınan etken maddenin hedef organ veya dokuya iletilmesi ile ilgilidir.The innovative aspect of the invention, as mentioned before, is about a drug delivery system that carries the active ingredient specifically for the target organ or tissue. The invention is essentially about coating the shape memory component that constitutes the drug delivery system in order to increase its biocompatibility and delivering the active substance incorporated into the coating material to the target organ or tissue.
Description
TARIFNAME SEKIL HAFIZALI ALASIMIN iLAç SALINIMINDA KULLANILDIGI BIR SISTEM TEKNIK ALAN Bulus, sekil hafiza gösteren metalik alasimin, biyouyumlu hale getirilmesi ve aktif ilaç saliniminda kullanilmasi için önerilen bir sistem ile ilgilidir. ÖNCEKI TEKNIK Sekil hafizali alasimlar (SHA olarak da kisaltilabilecektir); belirli sicaklik, mekanik yükler altinda veya bu iki durumun kombinasyonlari altinda sahip oldugu sekli hatirlayarak, kalici deformasyona ugramadan ilk sekline dönebilen bir alasim türüdür. Bu özellikleri sayesinde sekil hafizali alasimlar; havacilik, otomotiv, insaat alanlari ile sensörler gibi birçok ileri teknoloji alaninda yaygin olarak kullanilmaktadir. Sekil hafizali alasimlar sahip olduklari sekil hafiza özelliklere ek olarak, genellikle vücut içerisinde kullanildiginda toksik bir etki yaratmayan biyouyumluluk özelligi de göstermektedir. Sekil hafiza ve biyouyumluluk özelliklerini bir arada barindirmalari sebebiyle Sekil hafizali alasimlar; stentler, ortodontik teller, ortopedik implantlar gibi birçok biyomedikal uygulamada biyomalzeme olarak da kullan ilabilmektedir. Genellikle biyouyumluluklari yüksek olan sekil hafizali alasimlar, çogunlugu sividan mütesekkil ve korozif bir ortam olan insan vücuduyla etkilesime girdiginde iyon salinimi egilimi göstermektedir. Bunun sonucunda alasimlarin çevresinde arzu edilmeyen hasar mekanizmalari (iltihaplanma, implant gevsemesi vs.) olusabilmektedir. Söz gelimi Nikel-Titanyum (Ni-Ti) alasimlarindaki nikel vücuda bu gibi durumlarda salinabilmekte ve hem materyalin kullanimi sikintiya düserken hem de nikelin yaratacagi toksik etki de vücuda zarar verebilmektedir. Bu gibi dezavantajlari ortadan kaldirabilmek için Ni-Ti alasimlarinin biyouyumluluk özelliklerinin arttirilmasi gerekmektedir. Hidrojeller çapraz bagli polimerlerden olusan üç boyutlu, gözenekli bir yapiya sahip malzemelerdir. Yüksek su tutma kapasitesi ve toksik olmayan yapilari nedeniyle doku mühendisliginde ve bölgesel ilaç hedeflendirme isleminde yaygin olarak kullanilmaktadir. Hidrojeller klasik ve uyariya duyarli olarak ikiye ayrilir. Uyari duyarli diger bir degisle akilli hidrojellerin sisme dengeleri pH, sicaklik, elektriksel ortam ya da diger çevresel uyarilar ile hizla degisebilmektedir. Akilli hidrojeller bu niteliklerine göre sicaklik duyarli, pH duyarli, elektriksel uyarilara duyarli olarak siniflandirilmaktadir. Teknik alanda hidrojel temelli ilaç salim sistemleri, oral, rektal, oküler, epidermal, subkütan olarak kullanilmaktadir. Bu sistemler mikropartikül, nanopartikül, tablet, kaplama ve film gibi birçok fiziksel sekilde formüle edilmektedir. Kontrollü salim sistemleri bir etkin maddenin bir sistem içinden istenilen sürede, belirlenmis bir hizda ve gereken miktarda salinacak sekilde tasariminin yapildigi bir ilaç tasima sistemidir. Ilaçlar vücuda kontrollü salim yapan bir sistem içinde verildiginde istenen kan konsantrasyonu istenilen süre boyunca saglanmaktadir. Ayrica konvansiyonel kullanimda görülen sistemik toksik etkiler azalmaktadir. Ilaç salim kinetiginin belirli bir devamliliginin olmasi basarili bir uygulamanin kilit noktasidir. Sicaklik duyarli hidrojellerin sicakliga has davranislari ilaç salimini kontrol etmek için kullanilmaktadir. Çevreye duyarli hidrojeller sicaklik, pH, enzim, manyetik alan, iyonik kuvvet vb. dis etkilere verdikleri tepki ile ilaç salimini gerçeklestirmektedir. EP2285429 numarali bulus, implante edilebilir tibbi cihazlarla baglantili geç tromboz riskini azaltmak için bir polimer sistem tarif edilmektedir. EP2279013 numarali bulus, bulus genel olarak cerrahi prosedürler için kendi kendine tutucu sistemler, cerrahi prosedürler için kendi kendine tutucu sistemler üretme yöntemleri ve bunlarin kullanimlari ile ilgilidir. EP0415671 numarali bulus, bir etkin bilesenin yönetilerek ve yavaslatilarak midede salinimina yönelik bir sistemi açiklamaktadir. Sonuç olarak, sekil hafizali alasimlar vücut içerisinde çesitli görevlerde kullanimi esnasinda dezavantajlari ortadan kaldirabilecek ve aktif ilaç saliniminda güvenilir bir sekilde görev almasini saglayabilecek bir sistemin, ilgili teknik alan için yenilik kriterini saglayabilecegi düsünülmektedir. BULUSUN KISA AÇIKLAMASI Mevcut bulus, yukarida bahsedilen dezavantajlari ortadan kaldirmak ve ilgili teknik alana yeni avantajlar getirmek üzere, vücut içinde kullanilacak sekil hafizali alasimlarin iyon salinimi gibi zararli etkilerinin engellenmesi ve aktif ilaç saliniminda kullanilmasi için önerilen bir sistem ile ilgilidir. Bulusun bir amaci, sekil hafizali alasimlarin biyouyumlulugunun artmasini saglayacak bir sistem ortaya koymaktir. Bulusun bir amaci, sekil hafizali alasimlarin aktif ilaç saliniminda görev almasini saglayan bir sistem ortaya koymaktir. Bulusu bir amaci, etkin bilesen salinimin ihtiyaca yönelik dokuya ulasmasini saglayan bir sistem ortaya koymaktir. SEKILLERIN KISA AÇIKLAMASI Sekil 1'de bulus konusu ilaç tasima sistemi olan hidrojel ile kaplanmis Ni-Ti telin temsili görünümü yer almaktadir. Sekil 2'de bulus konusu ilaç tasima sistemin spesifik olarak hedef organa gitmesi esnasinda düz görüntüsü verilmektedir. Sekil 3'te bulus konusu ilaç tasima sistemin spesifik olarak hedef organa ulasmasi sonrasi belli açi ile egilerek bünyesinde yer alan etken maddeyi hedefe birakma görüntüsü verilmektedir. BU LUSUN DETAYLI AÇIKLAMASI Bu detayli açiklamada bulus konusu sekil hafiza özelligi gösteren metalik alasimin, daha biyouyumlu hale getirilmesi ve aktif ilaç saliniminda kullanilmasi için önerilen bir sistem ile ilgili olup, sadece konunun daha iyi anlasilmasina yönelik hiçbir sinirlayici etki olusturmayacak örneklerle açiklanmaktadir. Bulusta önerilen ilaç salinim sisteminde, sekil hafizali bilesen olarak Ni-Ti alasimlari kullanilmaktadir. Teknikte de bilindigi üzere Ni-Ti alasimlari, insan ve hayvan vücutlari için biyouyumlulugu yüksek materyallerden biridir. Fakat önceki teknikte de bahsedildigi üzere Ni-Ti alasimlarinin, uygun olmayan sartlar altinda vücuda nikel salinimi yapma tehlikesi bulunmaktadir. Önerilen sistem, Ni-Ti alasimlarinin biyouyumluluk açisindan güvenirligini en üst seviyeye tasimayi amaçlamaktadir. Bulusta kullanilan Ni-Ti alasimi, Sekil 1'de de gösterildigi üzere ince ve boyut olarak da bir o kadar küçük bir tel halindedir. Sözü edilen Ni-Ti alasimi teli, teknikte kullanilan standart katater tüplerinin uç kismina takilarak düz sekilde vücut içinde hedef bölgeye iletilebilmektedir. Telin boyutlari standart katater sistemleri ile tasinmaya uygun olmalidir. Bulusta önerilen sistemde Ni-Ti alasimi teli, polivinil alkol (PVA olarak kisaltilacaktir) hidrojel ile çok ince bir sekilde kaplanmaktadir. Teknikte de bilindigi üzere hidrojeller birçok sistemde de kaplama malzemesi olarak kullan ilabilmektedir. Teknikte birçok avantaji bilinen PVA hidrojel, mekanik özellikleri açisindan zayiftir. Bu sebeple vücuda direk verilen hidrojellerin, vücutta kalmasi ve istenilen seviyede kontrollü salim yapmasi mümkün olmamaktadir. Ni-Ti alasimlarinin üzerine kaplanmis hidrojel ilaç salinim sistemi ile hem Ni-Ti alasimlarinin biyouyumlulugu artmakta hem de ilaç saliniminda çok yaygin kullanimi olan hidrojellerin zayif mekanik özelliklerinin önüne geçmesi saglanacaktir. Ayrica hidrojellerin, yapisinin gözenekli olmasi, yüksek sivi tutma kapasitesi ve toksik olmamasi gibi özelliklerde ilaç saliniminda sik kullanilabilir bir malzeme olmasini saglamaktadir. Teknikte de bilindigi üzere hidrojeller, bünyesine etkin kimyasal bilesenler eklenerek hedef organlara kontrollü ilaç sal iniminda görev alabilmektedir. Bulusta önerilen ilaç tasima sistemi su sekildedir; Z sistemin iskeletini olusturan ve ilaç salinimi yapilacak hedef doku veya organa spesifik hareketini saglayan ve hedef doku veya organa ulasmasi sonrasi belirli açida yönelim yaparak etken maddenin hedef organ veya dokuya geçmesi saglanan bir sekil hafizali alasim tel; 2 sözü edilen sekil hafizali alasim teline hem kaplama görevi görerek vücuda toksik iyon salinimini engelleyen ayni zamanda ilaci bünyesinde tasiyan ve sekil hafizali alasim teli sarmalayacak bir 2 ve ilgili hedef organ veya dokuya sunulacak bir etken madde. Burada sözü edilen sekil hafizali alasim tel Ni-Ti telidir. Bulusta sözü edilen Ni-Ti tel bir PVA hidrojel ile kaplanir. Kaplanmis hafizali alasim teli vücuda alinir. Sekil hafizali alasim telin hidrojel kaplama malzemesi üzerinde yer alan etkin madde ile hedef organa düz bir sekilde iletilmektedir. Sekil 3'te gösterildigi üzere sistem, hedef organ veya dokuya geldiginde belli açi yaparak hedefe kontrollü salinim saglanir. Sözü edilen egilme açisi, 50 ile 1750 arasinda bir degerdir. Ni-Ti telin, vücut içinde istenen bölgeye getirilmesi standart katater sistemleriyle saglanacaktir. Ni-Ti telin çapi çok ince ve hidrojel kaplama sayesinde yumusak dokulu olacagindan vücuda girisi sirasinda herhangi bir zorluk yasanmayacaktir. Ilaç yüklenmis hidrojel kapli telin istenen açiyi alabilmesi için belli bir sicakliga gelmesi gerekmektedir. Bu isinma ise tele uygun bir akim degerinin verilmesi saglanmaktadir. Hareket için gerekli sicaklik seviyesi çevre doku ve epitele olasi zararlari engelleyecek mertebede (genel olarak < 50°C) ayarlanacaktir. Bulus konusu ilaç tasima sisteminin eldesi asagidaki islem adimlarini içerir; 2 Ni-Ti telin hazirlanmasi, 2 Ni-Ti tele ilaç yüklemesinin yapilmasi için gerekli PVA hidrojel kaplamanin solüsyonunun hazirlanmasi ve Ni-Ti telin hidrojel ile kaplanmasi, Z Ni-Ti ve hidrojel kaplama bünyesine hastalikli doku veya organa uygun bir etken madde eklenmesi Z egilme ve salinim özelliklerinin belirlenmesi için ilgili karakterizasyonlarin yapilmasidir. Bulusta sözü edilen Ni-Ti tele kaplama islemi daldirma yöntemi ile yapilmaktadir. Burada kullanilan kaplama solüsyonu gelatin ve PVA malzemelerinin karisimiyla hazirlanmaktadir ve elde edilen solüsyon içerisine Ni-Ti teller daldirilmak suretiyle kaplama islemine tabi tutulmaktadir. Ni-Ti tellerin hidrojeller ile kaplanmasi sayesinde vücuda Ni salinimi da engellenmektedir. Hidrojelin bir diger faydasi da yalitim görevi sayesinde herhangi bir isi sebepli doku zararinin önüne geçilecek olmasidir. Elde edilen ilaç tasima sisteminin (hidrojel kapli sekil hafizali alasimlar tel), hastalikli doku veya organa iletilmesi asagidaki islem adimlarini içerir; 2 standart katater vasitasiyla elde edilen ilaç tasima sisteminin, vücut içerisine alinmasi ve hedef doku veya organa ilerletilmesi, Z ilaç tasima sisteminin elektrik akimi uygulanmasiyla isinmasi ve önceden belirlenen açiya kadar egilmesi, Z egilme sonucu ilaç tasima sistemindeki hidrojel kaplamanin sikilmasiyla etken madde saliniminin gerçeklesmesi, Z ilaç tasima sisteminin katater vasitasiyla vücut disina çikarilmasi Bulusta sözü edilen standart kataterlere kamera yerlestirilebilmektedir. Bu sekilde vücut içerisinde hedef doku veya organa ulasmasinin daha kolay ve kesin sonuçlarla gerçeklesmesi saglanmaktadir. Akim verildikten sonra Ni-Ti isinmaktadir fakat hidrojel kaplamanin sayesinde olasi doku veya organa zarar verilmesi engellenmektedir. Hidrojel bünyesinde yer alan etken madde, çesitli zaman araliklarla hedef dokuya salinabilmektedir. Bulusun yenilikçi yönü daha öncesinde de belirtildigi üzere spesifik olarak hedef organ veya dokuya yönelik etken maddeyi tasiyan bir ilaç tasima sistemi üzerinedir. Bulus, hasarli veya hastalikli doku veya organa spesifik bir sekilde ulasmayi saglayan ve akabinde kontrollü ilaç salinimi saglayan bir sistem ile ilgilidir. Bulusta kullanilacak etken madde çok degisken olabilir. Kontrollü ilaç salinimin yapilabildigi hidrojellere uygun her türlü etken madde; bir analjezik veya antiinflamatuar ilaç, protein veya vitamin, nükleik asit, antikanser veya doku yenilenmesinde kullanilabilir bir ajan olabilmektedir. Etken madde olarak birçok farkli alandaki madde veya ajanlarda kullanilabilir. Bulusta önerilen ilaç tasima sistemi, hedef doku veya organa spesifik olarak etken maddenin tasinmasi ve kontrollü salinimi ile hem hastanin daha çabuk iyilesme sürecine girmesini hem de saglikli hücrelerin sözü edilen tedavi mekanizmalarindan etkilenmemesini saglamaktadir. TR TR TR TR DESCRIPTION A SYSTEM WHERE SHAPE MEMORY ALLOY IS USED IN DRUG RELEASE TECHNICAL FIELD The invention relates to a system proposed to make the shape memory alloy biocompatible and use it in active drug release. BACKGROUND ART Shape memory alloys (may also be abbreviated as SHA); It is a type of alloy that can return to its initial shape without suffering permanent deformation by remembering its shape under certain temperatures, mechanical loads or combinations of these two situations. Thanks to these properties, shape memory alloys; It is widely used in many advanced technology fields such as aviation, automotive, construction fields and sensors. In addition to their shape memory properties, shape memory alloys also show biocompatibility, which generally does not create a toxic effect when used in the body. Shape memory alloys due to their combination of shape memory and biocompatibility properties; It can also be used as a biomaterial in many biomedical applications such as stents, orthodontic wires, orthopedic implants. Shape memory alloys, which generally have high biocompatibility, tend to release ions when interacting with the human body, which is a corrosive environment composed mostly of liquids. As a result, undesirable damage mechanisms (inflammation, implant loosening, etc.) may occur around the alloys. For example, the nickel in Nickel-Titanium (Ni-Ti) alloys can be released into the body in such cases, and the use of the material may become problematic and the toxic effect of nickel may harm the body. In order to eliminate such disadvantages, the biocompatibility properties of Ni-Ti alloys need to be increased. Hydrogels are materials with a three-dimensional, porous structure consisting of cross-linked polymers. Due to its high water retention capacity and non-toxic structure, it is widely used in tissue engineering and regional drug targeting. Hydrogels are divided into two groups: classical and stimulus-sensitive. In other words, the swelling balance of smart hydrogels can change rapidly with pH, temperature, electrical environment or other environmental stimuli. Smart hydrogels are classified according to these qualities as temperature sensitive, pH sensitive, and sensitive to electrical stimuli. In the technical field, hydrogel-based drug delivery systems are used as oral, rectal, ocular, epidermal and subcutaneous. These systems are formulated in many physical forms such as microparticles, nanoparticles, tablets, coatings and films. Controlled release systems are a drug delivery system in which an active substance is designed to be released through a system in a desired time, at a specified rate and in the required amount. When drugs are given to the body in a controlled release system, the desired blood concentration is maintained for the desired period of time. In addition, systemic toxic effects seen in conventional use are reduced. Having a certain continuity of drug release kinetics is the key to a successful application. The temperature-specific behavior of temperature-sensitive hydrogels is used to control drug release. Environmentally sensitive hydrogels are sensitive to temperature, pH, enzyme, magnetic field, ionic strength, etc. They release the drug as a result of their response to external effects. Invention numbered EP2285429 describes a polymer system to reduce the risk of late thrombosis associated with implantable medical devices. The invention numbered EP2279013 is generally related to self-retaining systems for surgical procedures, methods of producing self-retaining systems for surgical procedures and their uses. The invention numbered EP0415671 discloses a system for directing and slowing the release of an active ingredient in the stomach. As a result, it is thought that a system that can eliminate the disadvantages of shape memory alloys while using them in various tasks within the body and enable them to function reliably in active drug release can meet the innovation criterion for the relevant technical field. BRIEF DESCRIPTION OF THE INVENTION The present invention is related to a system proposed to eliminate the above-mentioned disadvantages and bring new advantages to the relevant technical field, to prevent the harmful effects of shape memory alloys to be used in the body, such as ion release, and to use them in active drug release. One aim of the invention is to introduce a system that will increase the biocompatibility of shape memory alloys. One aim of the invention is to present a system that enables shape memory alloys to take part in active drug release. One of the aims of the invention is to present a system that ensures the release of active ingredients to reach the tissue in line with the need. BRIEF DESCRIPTION OF THE FIGURES Figure 1 shows a representative view of the Ni-Ti wire coated with hydrogel, which is the drug delivery system of the invention. Figure 2 shows the flat view of the drug delivery system of the invention while it is specifically delivered to the target organ. Figure 3 shows the appearance of the drug delivery system of the invention bending at a certain angle and releasing the active ingredient into the target after it reaches the specific target organ. DETAILED DESCRIPTION OF THE INVENTION In this detailed explanation, the invention is related to a system proposed to make the metallic alloy with memory feature more biocompatible and to use it in active drug release, and it is explained only with examples that will not create any limiting effect for a better understanding of the subject. In the drug delivery system proposed in the invention, Ni-Ti alloys are used as shape memory components. As is known in the art, Ni-Ti alloys are one of the materials with high biocompatibility for human and animal bodies. However, as mentioned in the previous technique, there is a danger that Ni-Ti alloys may release nickel into the body under unsuitable conditions. The proposed system aims to maximize the reliability of Ni-Ti alloys in terms of biocompatibility. The Ni-Ti alloy used in the invention is in the form of a thin and small wire, as shown in Figure 1. The Ni-Ti alloy wire in question can be attached to the tip of the standard catheter tubes used in the technique and transmitted straight to the target area within the body. The dimensions of the wire must be suitable for carrying with standard catheter systems. In the system proposed in the invention, the Ni-Ti alloy wire is coated very thinly with polyvinyl alcohol (abbreviated as PVA) hydrogel. As is known in the art, hydrogels can be used as coating materials in many systems. PVA hydrogel, which has many advantages in the technique, is weak in terms of its mechanical properties. For this reason, it is not possible for hydrogels administered directly to the body to remain in the body and provide controlled release at the desired level. With the hydrogel drug release system coated on Ni-Ti alloys, the biocompatibility of Ni-Ti alloys will be increased and the weak mechanical properties of hydrogels, which are widely used in drug release, will be prevented. In addition, hydrogels' porous structure, high liquid retention capacity and non-toxicity make them a frequently used material for drug release. As is known in the art, hydrogels can function in controlled drug delivery to target organs by adding active chemical components. The drug delivery system proposed in the invention is as follows; A shape memory alloy wire that forms the skeleton of the Z system and provides specific movement to the target tissue or organ where the drug will be released, and enables the active substance to pass into the target organ or tissue by orienting at a certain angle after reaching the target tissue or organ; 2, a shape memory alloy wire that acts as a coating and prevents the release of toxic ions into the body, and also carries the drug within itself and wraps the shape memory alloy wire, and an active substance that will be presented to the relevant target organ or tissue. The shape memory alloy wire mentioned here is Ni-Ti wire. In the invention, the Ni-Ti wire is coated with a PVA hydrogel. The coated memory alloy wire is taken into the body. The active substance on the hydrogel coating material of the shape memory alloy wire is delivered directly to the target organ. As shown in Figure 3, when the system reaches the target organ or tissue, controlled release to the target is achieved by making a certain angle. Said bending angle is a value between 50 and 1750. Bringing the Ni-Ti wire to the desired area within the body will be achieved with standard catheter systems. Since the diameter of the Ni-Ti wire will be very thin and soft-textured thanks to the hydrogel coating, there will be no difficulty in entering the body. The drug-loaded hydrogel-coated wire must reach a certain temperature in order to obtain the desired angle. This heating ensures that an appropriate current value is given to the wire. The temperature level required for movement will be set at a level that will prevent possible damage to the surrounding tissue and epithelium (generally < 50°C). Obtaining the drug delivery system of the invention includes the following process steps; Preparation of 2 Ni-Ti wires, preparation of the PVA hydrogel coating solution required for drug loading on 2 Ni-Ti wires and coating of the Ni-Ti wire with hydrogel, adding an active ingredient suitable for the diseased tissue or organ to the Z Ni-Ti and hydrogel coating Z bending and making relevant characterizations to determine the release properties. The Ni-Ti wire coating process mentioned in the invention is carried out by the dipping method. The coating solution used here is prepared by mixing gelatin and PVA materials, and the Ni-Ti wires are dipped into the resulting solution and subjected to the coating process. By coating Ni-Ti wires with hydrogels, Ni release into the body is also prevented. Another benefit of hydrogel is that it will prevent any heat-related tissue damage thanks to its insulation function. Delivering the resulting drug delivery system (hydrogel coated shape memory alloy wire) to the diseased tissue or organ involves the following process steps; Taking the drug delivery system obtained through 2 standard catheters into the body and advancing it to the target tissue or organ, Z heating the drug delivery system by applying electric current and bending it to a predetermined angle, Z releasing the active ingredient by squeezing the hydrogel coating in the drug delivery system as a result of bending, Z Taking the drug delivery system out of the body via a catheter. A camera can be placed in the standard catheters mentioned in the invention. In this way, it is ensured that it reaches the target tissue or organ within the body more easily and with accurate results. After the current is applied, Ni-Ti heats up, but thanks to the hydrogel coating, possible damage to the tissue or organ is prevented. The active ingredient contained in the hydrogel can be released into the target tissue at various time intervals. The innovative aspect of the invention, as stated before, is about a drug delivery system that carries the active ingredient specifically for the target organ or tissue. The invention relates to a system that provides specific access to damaged or diseased tissue or organ and subsequently provides controlled drug release. The active substance to be used in the invention may vary widely. Any active ingredient suitable for hydrogels that allow controlled drug release; It may be an analgesic or anti-inflammatory drug, protein or vitamin, nucleic acid, anticancer or tissue regeneration agent. It can be used as an active ingredient in substances or agents in many different fields. The drug delivery system proposed in the invention ensures that the patient undergoes a faster recovery process and that healthy cells are not affected by the mentioned treatment mechanisms, by specifically transporting and controlled release of the active substance to the target tissue or organ. TR TR TR TR
Claims (8)
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TR2022020810T2 true TR2022020810T2 (en) | 2023-02-21 |
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