TR2021021396A1 - INHIBITORY EFFECTS OF CHLOROGENIC ACID ON COX-1, COX-2 AND LOX ENZYMES - Google Patents
INHIBITORY EFFECTS OF CHLOROGENIC ACID ON COX-1, COX-2 AND LOX ENZYMESInfo
- Publication number
- TR2021021396A1 TR2021021396A1 TR2021/021396 TR2021021396A1 TR 2021021396 A1 TR2021021396 A1 TR 2021021396A1 TR 2021/021396 TR2021/021396 TR 2021/021396 TR 2021021396 A1 TR2021021396 A1 TR 2021021396A1
- Authority
- TR
- Turkey
- Prior art keywords
- chlorogenic acid
- cox
- inflammatory agent
- inflammatory
- inhibitory effects
- Prior art date
Links
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 title claims abstract description 30
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 title claims abstract description 30
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 title claims abstract description 30
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 title claims abstract description 30
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 title claims abstract description 30
- 229940074393 chlorogenic acid Drugs 0.000 title claims abstract description 30
- 235000001368 chlorogenic acid Nutrition 0.000 title claims abstract description 30
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 title claims abstract description 30
- 102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 title claims description 7
- 108050003243 Prostaglandin G/H synthase 1 Proteins 0.000 title claims description 7
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 title claims description 5
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 title claims description 5
- 230000002401 inhibitory effect Effects 0.000 title description 4
- 102000004190 Enzymes Human genes 0.000 title description 3
- 108090000790 Enzymes Proteins 0.000 title description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims abstract description 24
- 239000002260 anti-inflammatory agent Substances 0.000 claims abstract description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
- 239000002552 dosage form Substances 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 229960001259 diclofenac Drugs 0.000 claims description 4
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 4
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 3
- 229960001680 ibuprofen Drugs 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 2
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 241000245665 Taraxacum Species 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- -1 sachet Substances 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 229940098466 sublingual tablet Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
Abstract
Mevcut buluş, antienflamatuvar ajan olarak kullanım için klorojenik asit maddesi ile ve bu maddeyi içeren farmasötik bileşimlerle ilgilidir.The present invention relates to chlorogenic acid for use as an anti-inflammatory agent and to pharmaceutical compositions containing it.
Description
TARIFNAME KLOROJENIK ASITIN COX-l, COX-2 VE LOX ENZIMLERINI INHIBE EDICI ETKILERI Teknik Alan Mevcut bulus, antienflamatuvar ajan olarak kullanim için klorojenik asit maddesi ile ve bu maddeyi içeren farrnasötik bilesimlerle ilgilidir. Teknigin Bilinen Durumu Entlamasyon kaynakli rahatsizliklar siklikla karsimiza çikmaktadir. Vücudun farkli bölgelerinde farkli nedenlerle meydana gelen enflamasyonlarin tedavisi çesitli konvansiyonel ilaçlarla saglanmaya çalisilmaktadir. Ancak kullanilan bu ajanlarla tedavi zaman zaman yetersiz kalmakla beraber yeni ve dogal antienflamatuar aj anlarin kesfi büyük Önem tasimaktadir. Dogal kaynakli terapötik ajanlarin ticari kullaniminda en çok karsilasilan problemlerden biri dogal ürünlerden elde edilen ekstrelerin içerisindeki farmasötik etkiye sahip madde miktarinin sabit olmamasidir. Bitkinin toplandigi bölgeye veya toplandigi döneme göre degisiklik gösterebilen burn iktar degisikligi, bitkisel kökenli ekstreler kullanilarak etkinligi tekrar edilebilir ve standardize edilebilir formülasyonlar gelistirilmesini engellemektedir. Teknigin bilinen durumu göz önüne alindiginda hem bitkisel veya dogal kaynaklardan elde edilen hem de içerisinde bulunan farmasötik etkinlik gösteren madde miktari yönünden standardize edilebilen antienflamatuar ajanlara ihtiyaç oldugu görülmektedir. Bulusun Amaci Bulus sahipleri, bitkisel veya dogal kaynaklardan elde edilen ve içerisinde bulunan farmasötik etkinlik gösteren madde miktari yönünden standardize edilebilen antienilamatuar ajanlar gelistirmeyi amaçlamaktadir. Bulusun Kisa Açiklamasi Mevcut bulus antienflamatuvar ajan olarak kullanim için klorojenik asit maddesine veya herhangi bir oranda örnegin %0,I - %99 oraninda klorojenik asit içeren bilesiklere, tercihen %0,I - %99 oraninda klorojenik asit içeren bitki esktrelerine, özellikle tercihen %0,] ile "095 oraninda klorojenik asir içeren Taraxacum ogîci'nale toprak üstü kisimlarinin ekstresine, örnegin %O,1-%2 oraninda klorojenik asit içeren T araxaciim ofjîci'nale toprak üstü kisimlarinin ekstresine yöneliktir. Ayrica, COX ve LOX enzimlerini selektif olarak inhibe eden çok fazla ajan olmamasi nedeniyle, bulusa uygun antienilamatuvar ajan olarak kullanim için klorojenik asit ile hastalara dogal bir antientlamatuar ajan saglanmaktadir. Bulusun Detayli Anlatimi Bulusun bir uygulamasi antienflamatuvar ajan olarak kullanim için en az %95 saflikta klorojenik asite iliskindir. Bulusun tercih edilen bir uygulamasi antienflamatuar ajan olarak kullanim için % 95-99 saflikta kloroj enik asite iliskindir. Bulusun özellikle tercih edilen bir uygulamasi antienflamatuar ajan olarak kullanim için % 97-99 saflikta klorojenik asite iliskindir. Bulus kapsaminda bahsedilen % sailikta klorojenik asit miktari, standardize ajanin Türk Farmakopesi-II monograflar (Avrupa farmakopesi adaptasyonu) - 2016 isimli kaynakta (TC. Saglik Bakanligi, Türkiye Ilaç ve Tibbi cihaz kurumu, I. Baski, 2016) klorojenik asit tayininde kullanilan herhangi bir analiz yöntemi örnegin HPLC ve/veya HPTLC cihazi analizleri ile belirlenmektedir. Bu bulus kapsaminda bahsi geçen % orani relatif bir oran olup, analize tabi tutulan klorojenik asit numunesindeki toplam madde miktarina kiyasla klorojenik asit miktarini ifade etmektedir. Örnegin, bir klorojenik asit numunesinin HPLC analizinde elde edilen tüm pik alani 100 ile ifade edilecek olursa, bulusa uygun bir kloroj enik asit numunesinde klorojenik asit°e karsilik gelen pikin alani en az 95 olmalidir. Burada kullanilan antientlamatuar ajan ifadesi, COX-l ve/Veya COX-2 ve/veya LOX inhibitörü etkisi gösteren aj anlari da kapsamaktadir. Bulus bir diger açidan, antienflamatuvar ajan olarak kullanima uygun etken madde olarak en az Bulusun bir diger unsuru, etken madde olarak en az %95 saflikta, tercihen %95-99 satlikta, özellikle tercihen %97-99 saflikta klorojenik asit içeren farrnasötik bilesimlerde bahsi geçen bu etken maddeye ilave olarak bir diger antienflamatuar ajan kullanilmasidir. Bulusun bir uygulamasinda bahsi geçen ilave antienflamatuar ajan ibuprofen veya diklofenak olabilir. Bulusa uygun kombinasyonlar, ayni dozaj formunda veya farkli dozaj fonnlarinda formüle edilebilir. Bulusa uygun kombinasyon forrnülasyonlarinin farkli dozaj formlarinda formüle edilmesi durumunda bahsi geçen forrnülasyonlar farkli zamanlarda veya ayni anda veya sirali olarak kullanilabilir. Bulusa uygun formülasyonlar oral veya topikal kullanima uygun bir dozaj formunda formüle edilebilir. Oral forrnülasyonlar, tablet, kapsül, uzun salinimli kapsül, geciktirilmis salinimli kapsül, surup, emülsiyon, süspansiyon, kaplamali tablet, katmanli tablet, agizda dagilan tablet, efervesan tablet, sase, dil alti tablet forrnlarindan herhangi birinde olabilir. Topikal forrnülasyonlar, merhem, krem, jel, hidrojel, losyon formlarindan herhangi birinde olabilir. Bulusa uygun formülasyonlar içerisinde klorojenik asite ek olarak fannasötik olarak kabul edilebilir en az bir yardimci madde olabilir. Bahsi geçen yardimci madde, herhangi bir terapötik etkisi olmayip, formülasyonun hazirlanmasi veya korunmasi veya kullanimi esnasinda ortaya çikan bir gereksinimi karsilamak için kullanilabilir. Endüstriye Uygulanabilirlik Bulus sayesinde antienflamatuar ajan olarak kullanima uygun dogal kökenli ajanlar gelistirilmistir. Bu yönüyle bulus hem saglik sektöründeki son kullanicilari hem de ilaç gelistiricilerini il gilendirmektedir. Örnekler Örnek 1: Bulusa uygun en az %95 safliga sahip klorojenik asit numunesinin COX-l ve COX-Z inhibisyonu için 1C50 degerleri ve bilinen antienflamatuar ajanlarla karsilastirilmasi Asagida sonuçlari verilen çalismada kullanilan klorojenik asit numunesi içerisinde % 95 klorojenik asit bulunmaktadir. Madde No. ICso (ug/mL) SI Örnek 17de yer alan sonuçlar degerlendirildiginde bulusa uygun en az %95 klorojenik asit içeren numunenin dogal bir madde olmasina ragmen ticari olarak uzun sürelerdir kullanilan diklofenak ve ibuprofen gibi antienflamatuvar ajanlardan daha iyi antienflamatuar etki gösterdigi görülmektedir. Burada görüldügü üzere, bulusa uygun dogal ajan diklofenak molekülüne kiyasla COX-l ve COK-2 inhibisyonu açisindan daha iyi etkinlik, bir diger deyisler. daha yüksek antienflamatuar etki, spesifik olarak COX-l ve COX-2 inhibitör etkisi göstermektedir. Tüm bu deney verileri bu dogal kaynakli standardize maddenin önemli bir antieflamatuar ajan olabilecegini ortaya koymaktadir. TR TR TR TR DESCRIPTION INHIBITORY EFFECTS OF CHLOROGENIC ACID ON COX-1, COX-2 AND LOX ENZYMES Technical Field The present invention relates to the substance chlorogenic acid for use as an anti-inflammatory agent and to pharmaceutical compositions containing this substance. Known Status of the Technique Disorders caused by entlamination occur frequently. Inflammations that occur in different parts of the body for different reasons are tried to be treated with various conventional drugs. However, although treatment with these agents is sometimes insufficient, the discovery of new and natural anti-inflammatory agents is of great importance. One of the most encountered problems in the commercial use of naturally derived therapeutic agents is that the amount of substances with pharmaceutical effects in the extracts obtained from natural products is not constant. Variation in nose quantity, which may vary depending on the region where the plant is collected or the period in which it is collected, prevents the development of reproducible and standardizable formulations using plant-derived extracts. Considering the known state of the art, it seems that there is a need for anti-inflammatory agents that are obtained from herbal or natural sources and can be standardized in terms of the amount of pharmaceutically active substances they contain. Purpose of the Invention The inventors aim to develop anti-inflammatory agents that are obtained from herbal or natural sources and can be standardized in terms of the amount of pharmaceutically active substances they contain. Brief Description of the Invention The present invention relates to chlorogenic acid for use as an anti-inflammatory agent or to compounds containing chlorogenic acid in any proportion, such as 0.1% to 99%, preferably plant extracts containing 0.1% to 99% chlorogenic acid, particularly preferably 0%. ,] is directed to the extract of aerial parts of Taraxacum ogîci'nale containing 0.95% of chlorogenic acid, for example, to the extract of aboveground parts of Taraxacum ofjîci'nale containing 0.1%-2% chlorogenic acid. In addition, it selectively inhibits COX and LOX enzymes. Since there are not many agents available, a natural anti-inflammatory agent is provided to patients with chlorogenic acid for use as an anti-inflammatory agent in accordance with the invention. Detailed Description of the Invention A preferred embodiment of the invention relates to chlorogenic acid with at least 95% purity for use as an anti-inflammatory agent. Relates to 95-99% purity chlorogenic acid for use as an agent. A particularly preferred embodiment of the invention relates to 97-99% pure chlorogenic acid for use as an anti-inflammatory agent. The % amount of chlorogenic acid mentioned within the scope of the invention does not correspond to any standard agent used in the determination of chlorogenic acid in the source named Turkish Pharmacopoeia-II monographs (European pharmacopoeia adaptation) - 2016 (Turkish Ministry of Health, Turkish Medicine and Medical Device Agency, I. Edition, 2016). The analysis method is determined, for example, by HPLC and/or HPTLC device analysis. Within the scope of this invention, the percentage mentioned is a relative ratio and expresses the amount of chlorogenic acid compared to the total amount of substance in the chlorogenic acid sample subjected to analysis. For example, if the entire peak area obtained in the HPLC analysis of a chlorogenic acid sample is expressed as 100, the area of the peak corresponding to chlorogenic acid in a chlorogenic acid sample according to the invention must be at least 95. The term anti-inflammatory agent used here also includes agents that have COX-1 and/or COX-2 and/or LOX inhibitory effects. In another aspect, the invention refers to the active ingredient suitable for use as an anti-inflammatory agent in pharmaceutical compositions containing at least 95% purity, preferably 95-99% purity, especially preferably 97-99% purity chlorogenic acid as the active ingredient. In addition to this active ingredient, another anti-inflammatory agent is used. In one embodiment of the invention, said additional anti-inflammatory agent may be ibuprofen or diclofenac. The combinations according to the invention can be formulated in the same dosage form or in different dosage forms. If the combination formulations according to the invention are formulated in different dosage forms, said formulations can be used at different times or simultaneously or sequentially. The formulations according to the invention can be formulated in a dosage form suitable for oral or topical use. Oral formulations can be in any of the forms of tablet, capsule, extended-release capsule, delayed-release capsule, syrup, emulsion, suspension, coated tablet, layered tablet, orodispersible tablet, effervescent tablet, sachet, or sublingual tablet. Topical formulations can be in any of the forms of ointment, cream, gel, hydrogel or lotion. In addition to the chlorogenic acid, the formulations according to the invention may contain at least one pharmaceutically acceptable excipient. Said excipient does not have any therapeutic effect and may be used to meet a need arising during the preparation or preservation of the formulation or during its use. Industrial Applicability Thanks to the invention, natural origin agents suitable for use as anti-inflammatory agents have been developed. In this respect, the invention interests both end users in the healthcare sector and drug developers. Examples Example 1: Comparison of 1C50 values for COX-1 and COX-Z inhibition and known anti-inflammatory agents of a chlorogenic acid sample with at least 95% purity in accordance with the invention. The chlorogenic acid sample used in the study whose results are given below contains 95% chlorogenic acid. Item No. ICso (ug/mL) SI When the results in Example 17 are evaluated, it is seen that the sample containing at least 95% chlorogenic acid in accordance with the invention has a better anti-inflammatory effect than anti-inflammatory agents such as diclofenac and ibuprofen, which have been used commercially for a long time, even though it is a natural substance. As seen here, better efficacy in terms of COX-1 and COK-2 inhibition compared to the natural agent diclofenac molecule according to the invention, in other words. It shows higher anti-inflammatory effect, specifically COX-1 and COX-2 inhibitory effect. All these experimental data reveal that this standardized substance of natural origin may be an important anti-inflammatory agent. TR TR TR TR
Claims (1)
Publications (1)
Publication Number | Publication Date |
---|---|
TR2021021396A1 true TR2021021396A1 (en) | 2023-07-21 |
Family
ID=
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2003286549C1 (en) | Compositions that treat or inhibit pathological conditions associated with inflammatory response | |
US8557306B2 (en) | Compositions that treat or inhibit pathological conditions associated with inflammatory response | |
US7270835B2 (en) | Compositions that treat or inhibit pathological conditions associated with inflammatory response | |
US20120183634A1 (en) | Synergistic Compositions That Treat or Inhibit Pathological Conditions Associated With Inflammatory Response | |
US7722903B2 (en) | Modulation of inflammation by hops fractions and derivatives | |
Bocci et al. | Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases? | |
Keshavarz-Bahaghighat et al. | Acetyl-L-carnitine attenuates arsenic-induced oxidative stress and hippocampal mitochondrial dysfunction | |
Kismet et al. | Does propolis have any effect on non-alcoholic fatty liver disease? | |
ES2354001T3 (en) | CURCUMA LONGA EXTRACT AND ITS COSMETIC OR DERMOPHARMACEUTICAL APPLICATIONS. | |
Kale et al. | Acridocarpus smeathmannii (DC.) Guill. & Perr. Root enhanced reproductive behavior and sexual function in male wistar rats: Biochemical and pharmacological mechanisms | |
TR2021021396A1 (en) | INHIBITORY EFFECTS OF CHLOROGENIC ACID ON COX-1, COX-2 AND LOX ENZYMES | |
TR2021021389A1 (en) | INHIBITORY EFFECTS OF ROSMARINIC ACID ON COX-1, COX-2 AND LOX ENZYMES | |
TR2021021403A1 (en) | INHIBITORY EFFECTS OF VITEXIN-2-O-RAMNOSITE ON COX-1, COX-2 AND LOX ENZYMES | |
TR2021021394A1 (en) | INHIBITORY EFFECTS OF SALVIGENIN ON COX-1, COX-2 AND LOX ENZYMES | |
TR2021021374A1 (en) | INHIBITORY EFFECTS OF ALLICIN ON COX-1, COX-2 AND LOX ENZYMES | |
TR2021021379A1 (en) | INHIBITORY EFFECTS OF MALVIN ON COX-1, COX-2 AND LOX ENZYMES | |
TR2021021375A2 (en) | INHIBITORY EFFECTS OF STANDARDIZED EXTRACTS OF ALLIUM SATIVUM L. ONIONS ON COX-1, COX-2 AND LOX ENZYMES | |
Alabdallat | In-vivo antioxidant effects of the orally administered paracetamol, aqueous extracts of saliva triloba, and origanum syriacum | |
TR2021021378A1 (en) | INHIBITORY EFFECTS OF STANDARDIZED EXTRACTS OF MALVA SYLVESTRIS L. FLOWERS ON COX-1, COX-2 AND LOX ENZYMES | |
TR2021021372A1 (en) | INHIBITORY EFFECTS OF STANDARDIZED EXTRACTS OF CRATAEGUS MONOYGNA FRUITS AND FLOWERING LEAVES ON COX-1, COX-2 AND LOX ENZYMES | |
TR2021021393A2 (en) | INHIBITORY EFFECTS OF STANDARDIZED EXTRACTS OF SALVIA TRILOBA LEAVES ON COX-1, COX-2 AND LOX ENZYMES | |
TR2021021399A2 (en) | INHIBITORY EFFECTS OF STANDARDIZED EXTRACTS OF TARAXACUM OFFICINALE AERIAL PARTS ON COX-1, COX-2 AND LOX ENZYMES | |
WO2023128991A1 (en) | Inhibitory effects of standardized extracts of taraxacum officinale aerial parts on cox-1, cox-2 and lox enzymes | |
TR2021021391A2 (en) | INHIBITORY EFFECTS OF STANDARDIZED EXTRACTS OF ROSMARINUS OFFICINALIS L. LEAVES ON COX-1, COX-2 AND LOX ENZYMES | |
WO2023128999A1 (en) | Natural compounds with anti-inflammatory effect |