TR2021019595A2 - HEMODIALIZER WITH INCREASED FILTRATION PERFORMANCE - Google Patents
HEMODIALIZER WITH INCREASED FILTRATION PERFORMANCEInfo
- Publication number
- TR2021019595A2 TR2021019595A2 TR2021/019595A TR2021019595A TR2021019595A2 TR 2021019595 A2 TR2021019595 A2 TR 2021019595A2 TR 2021/019595 A TR2021/019595 A TR 2021/019595A TR 2021019595 A TR2021019595 A TR 2021019595A TR 2021019595 A2 TR2021019595 A2 TR 2021019595A2
- Authority
- TR
- Turkey
- Prior art keywords
- channel
- flow
- blood
- membrane
- dialysate
- Prior art date
Links
- 238000001914 filtration Methods 0.000 title description 4
- 239000008280 blood Substances 0.000 claims abstract description 14
- 210000004369 blood Anatomy 0.000 claims abstract description 14
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000004202 carbamide Substances 0.000 claims abstract description 11
- 239000012528 membrane Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 7
- 238000005370 electroosmosis Methods 0.000 claims description 6
- 210000005036 nerve Anatomy 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims 1
- 238000001631 haemodialysis Methods 0.000 abstract description 9
- 230000000322 hemodialysis Effects 0.000 abstract description 9
- 206010016717 Fistula Diseases 0.000 abstract description 3
- 230000003890 fistula Effects 0.000 abstract description 3
- 230000002792 vascular Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- 238000007485 conventional hemodialysis Methods 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 229920002284 Cellulose triacetate Polymers 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
- B01D61/427—Electro-osmosis
Abstract
Buluş; tıpta fistül, greft ya da kateter adı verilen uygun bir vasküler giriş yolu kullanılarak hastadan alınan kanın, bir makine ve pompa yardımıyla diyalizör adı verilen bir süzgeçten geçirilmesi yoluyla kan içindeki üre miktarını insan sağlığına zarar vermeyecek düzeylere indirgeyerek hastaya geri verilmesi şeklinde çalışan hemodiyaliz ünitesinin kritik bir parçası olan hemodiyalizörde yapılan yeniliklerle ilgilidir.Meet; In medicine, the hemodialysis unit, which works in the form of reducing the amount of urea in the blood to levels that will not harm human health, by passing the blood taken from the patient through a filter called a dialyzer with the help of a machine and pump, using an appropriate vascular access route called a fistula, graft or catheter, is a critical part of the hemodialysis unit. It is about the innovations made in the hemodialyzer, which is a part of it.
Description
TARIFNAME FILTRASYON PERFORMANSI ARTTIRILMIS HEMODIYALIZÖR TEKNIK ALAN Bulus; tipta fistül, greft ya da kateter adi verilen uygun bir vasküler giris yolu kullanilarak hastadan alinan kanin, bir makine ve pompa yardimiyla diyalizör adi verilen bir süzgeçten geçirilmesi yoluyla kan içindeki üre miktarini insan sagligina zarar vermeyecek düzeylere indirgeyerek hastaya geri verilmesi seklinde çalisan hemodiyaliz ünitesinin kritik bir parçasi olan hemodiyalizörde yapilan yeniliklerle ÖNCEKI TEKNIK Hemodiyaliz; tipta fistül, greft ya da kateter adi verilen uygun bir vasküler giris yolu kullanilarak hastadan alinan kanin, bir makine ve pompa yardimiyla diyalizör adi verilen bir süzgeçten geçirilmesi yoluyla kan içindeki üre miktarini insan sagligina zarar vermeyecek düzeylere indirgeyerek hastaya geri verilmesi olarak tanimlanmaktadir. DESCRIPTION FILTRATION PERFORMANCE INCREASED HEMODIYALYZER TECHNICAL FIELD Meet; type of fistula, a suitable vascular access route called a graft or catheter The blood taken from the patient using a machine and a pump is called a dialyzer. the amount of urea in the blood by passing it through a given filter is harmful to human health. working in the form of giving it back to the patient by reducing it to levels that will not give With the innovations made in the hemodialyzer, which is a critical part of the hemodialysis unit, PRIOR ART hemodialysis; type of fistula, a suitable vascular access called a graft or catheter The blood taken from the patient using the dialysis method is called a dialyzer with the help of a machine and a pump. the amount of urea in the blood by passing it through a given filter is harmful to human health. It is defined as giving it back to the patient by reducing it to levels that do not give treatment.
Bilinen teknikteki hemodiyalizörde kanin üre filtrasyon degerinin görece düsüklügü hastanin rutin diyaliz seansi süresini uzatmaktadir. Dolayisiyla, hastada hemodiyalize bagli yasami tehdit eden kronik komplikasyonlar (anemi, kardiyovasküler bozukluklar, pulmoner bozukluklar, immünolojik anomaliler vs.) daha erken ortaya çikmaktadir. Bu komplikasyonlar hastalarin olasi böbrek nakline de engel olabilmektedir ve çok uzun süreli hemodiyaliz kullanimi ölüme yol açmaktadir. Ayrica, vücudun toksik maddelerden yeterince hizli arindirilamamasi diyaliz seansi esnasinda hastalarda akut komplikasyonlarin (hipotansiyon. kramp, mide bulantisi ve kusma, bas agrisi vs.) gelisme ihtimalini arttirmaktadir. Relative low blood urea filtration value in the prior art hemodialyzer prolongs the duration of the patient's routine dialysis session. Therefore, hemodialysis in the patient related life-threatening chronic complications (anemia, cardiovascular disorders, pulmonary disorders, immunological anomalies, etc.) occur earlier. This Complications may also prevent patients from possible kidney transplantation and may take a very long time. Long-term use of hemodialysis leads to death. In addition, the body's toxic Inability to get rid of substances quickly enough in patients during the dialysis session acute complications (hypotension, cramps, nausea and vomiting, headache, etc.) increases the likelihood of development.
SEKIL LISTESI Sekil 1. Dielektrik ve Gözenekli Bir Maddeden Elde Edilen Bosluklu Fiber Membran Hemodiyalizör Sisteminin Bir Ünitesinin Silindirik Koordinatlarda (r=0) Iki Boyutlu Sematik Görünümü Sekillerde verilen numaralarin karsiliklari söyledir; 1. Birinci Kanal 2. Membran 3. Ikinci Kanal Gaussian Sütun (Pillar) Pozitif Yüklü Elektrot (Kan akisi için) Topraklanmis Elektrot(Kan akisi için) Pozitif Yüklü Elektrot (Diyalizat akisi için) 95339391.“ Topraklanmis Elektrot (Diyalizat akisi için) BULUSUN DETAYLI AÇIKLAMASI Bulus; dielektrik ve gözenekli bir yapiya sahip (selüloz triasetat vb.) bir maddeden elde edilen bosluklu fiber membran hemodiyalizör sisteminin bir ünitesi silindirik koordinatlarda iki boyutlu düzlemde sekil 1'de sematik olarak gösterilmistir. LIST OF FIGURES Figure 1. Hollow Fiber from a Dielectric and Porous Material Cylindrical Coordinates of a Unit of Membrane Hemodialyzer System (r=0) Two-Dimensional Sematic View The corresponding numbers in the figures are as follows; 1. Channel One 2. Membrane 3. Second Channel Gaussian Column (Pillar) Positively Charged Electrode (For blood flow) Grounded Electrode (For blood flow) Positively Charged Electrode (For Dialysate flux) 95339391.“ Grounded Electrode (For Dialysate flow) DETAILED DESCRIPTION OF THE INVENTION Meet; a dielectric and porous structure (cellulose triacetate, etc.) a unit of a hollow fiber membrane hemodialyzer system derived from It is shown schematically in figure 1 in a two-dimensional plane in cylindrical coordinates.
Sekil 1'de 2 ekseni simetri ekseni olarak tanimlanmistir. Hastadan alinan üre bakimindan zengin kan birinci kanaldan (1) +2 yönünde elektroosmotik akis ile tasinmaktadir. Bu sebeple, +z yönünde Dogru Akim elektriksel kuvvetin sisteme tanitilmasi için tabandaki giris siniri kan için pozitif yüklü elektrot (5), tepedeki çikis siniri topraklanmis elektrot (6) olarak belirlenmistir. Bu esnada, kanda çözülmüs üre, membran (2) bölgesi üzerinden +r yönünde tasinim yapmaktadir. Ikinci kanalda (3) ise -2 yönünde diyalizat akisi saglanmaktadir. Bu sebeple, -z yönünde Dogru Akim elektriksel kuvvetin sisteme tanitilmasi için tepedeki giris siniri diyalizat için pozitif yüklü elektrot (7), tabandaki çikis siniri topraklanmis elektrot (8) olarak belirlenmistir. In Figure 1, the 2 axis is defined as the symmetry axis. Urea taken from the patient rich blood from the first channel (1) with electroosmotic flow in the +2 direction is being transported. For this reason, the Direct Current electrical force in the +z direction is applied to the system. The entrance nerve at the base is the positively charged electrode (5) for blood, the outlet at the top The boundary is determined as the grounded electrode (6). Meanwhile, urea dissolved in the blood, it is transported in the +r direction over the membrane (2) region. If in the second channel (3) Dialysate flow is provided in the -2 direction. Therefore, Direct Current in the -z direction the upper input nerve is positive for the dialysate to introduce the electrical force to the system The charged electrode (7) is determined as the electrode (8) whose output boundary is grounded at the base.
Zit yöndeki diyalizat akisi ile birinci kanal (1) ve ikinci kanal (3) arasindaki üre konsantrasyon farki hemodiyaliz uygulamasi boyunca korunmakta ve madde tasinim veriminin azalmasi önlenmektedir. The urea between the dialysate flow in the opposite direction and the first channel (1) and the second channel (3) concentration difference is maintained throughout the hemodialysis application and substance transport decrease in efficiency is prevented.
Kanda temizlenen üre miktarinin bir ölçüsü olan üre klirensinin (urea clearance) arttirilmasi, Dogru Akim (DA) elektroosmotik akis ve membran yüzey alaninin arttirilmasi yöntemlerinden en az biri kullanilarak saglanmaktadir. Bu sayede, filtre edilecek toksik madde ile membranin temas etkinliginin artmasi saglanmaktadir. Urea clearance, which is a measure of the amount of urea cleared in the blood Increasing Direct Current (DC) electroosmotic flow and membrane surface area It is provided by using at least one of the increasing methods. In this way, the filter It is ensured that the contact efficiency of the membrane with the toxic substance to be increased is increased.
Bilinen teknikteki ticari hemodiyaliz cihazlarinda isletilen basinç tahrikli akis yerine, bulusta elektroosmotik akis kullanilmaktadir. Membran (2) yüzey alaninin arttirilmasi için yüzeye belirli araliklarla Gauss fonksiyonundan türetilen sütun geometrileri (Gaussian Sütun Pillar) (4) yerlestirilmistir. Instead of pressure driven flow operated in commercial hemodialysis devices of the known art, electroosmotic flow is used in the invention. Increasing the surface area of the membrane (2) column geometries derived from the Gaussian function at certain intervals to the surface (Gaussian Column Pillar) (4) is placed.
Basinç tahriki ile akista; membran (2) yüzeyinde hiz siddetinin sifir oldugu ve birinci kanal (1) ile ikinci kanalin (3) merkezinde maksimum hiz siddetine sahip olan parabolik bir hiz profili elde edilmektedir. Buna karsin, elektroosmotik akista birinci kanal (1) ve ikinci kanal (3) genisligi boyunca sivi akisinin hiz siddetleri uniform dagilim göstermektedir. Elektroosmotik akisin membran (2) yüzeyindeki hizinin siddeti basinç tahriki ile olusan akistan farkli olmasi nedeni ile madde tasinim miktarinin arttirilmasi saglanmaktadir. Membran (2) yüzeyinin tamamina Gauss fonksiyonundan türetilen sütun geometrileri (Gaussian Sütun Pillar) (4) yerlestirilmesi de yüzey alaninda önemli bir artis saglamaktadir. Her iki yöntem de geleneksel hemodiyaliz cihazina göre daha etkin bir kimyasal tür-membran etkilesimini mümkün kilmaktadir. Yapilan ön çalismalar sonucunda bilinen teknikteki geleneksel hemodiyaliz ünitesi ile bulusa konu hemodiyaliz ünitesinin hemodiyalizörü arasinda kararli hal klirens degerleri karsilastirildiginda bulusa konu hemodiyalizör ile yapilan islemlerde filtrasyon veriminin önemli ölçüde yükseldigi görülmüstür. Aksta with pressure drive; the velocity on the membrane (2) surface is zero and having maximum velocity in the center of the first channel (1) and the second channel (3) A parabolic velocity profile is obtained. However, the first in the electroosmotic flow uniform distribution of the velocity intensities of the liquid flow along the width of the channel (1) and the second channel (3) shows. The intensity of the velocity of the electroosmotic flow on the surface of the membrane (2) pressure Increasing the amount of material transport due to the difference in the flow created by the drive is provided. The entire surface of the membrane (2) is derived from the Gaussian function. The placement of column geometries (Gaussian Column Pillar) (4) is also important in the surface area. provides an increase. Both methods are more efficient than the conventional hemodialysis device. It enables an effective chemical species-membrane interaction. pre-made As a result of the studies, it was the subject of the invention with the conventional hemodialysis unit of the known technique. steady-state clearance values between the hemodialyzer of the hemodialysis unit filtration in the processes performed with the hemodialyzer, which is the subject of the invention. yield was found to be significantly increased.
Claims (3)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2021/019595A TR2021019595A2 (en) | 2021-12-10 | 2021-12-10 | HEMODIALIZER WITH INCREASED FILTRATION PERFORMANCE |
| PCT/TR2021/051393 WO2023107019A1 (en) | 2021-12-10 | 2021-12-11 | A hemodialyzer with enhanced filtration performance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2021/019595A TR2021019595A2 (en) | 2021-12-10 | 2021-12-10 | HEMODIALIZER WITH INCREASED FILTRATION PERFORMANCE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR2021019595A2 true TR2021019595A2 (en) | 2021-12-21 |
Family
ID=85114225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2021/019595A TR2021019595A2 (en) | 2021-12-10 | 2021-12-10 | HEMODIALIZER WITH INCREASED FILTRATION PERFORMANCE |
Country Status (2)
| Country | Link |
|---|---|
| TR (1) | TR2021019595A2 (en) |
| WO (1) | WO2023107019A1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486286A (en) * | 1991-04-19 | 1996-01-23 | Althin Medical, Inc. | Apparatus for performing a self-test of kidney dialysis membrane |
| JP2001178817A (en) * | 1999-12-24 | 2001-07-03 | Terumo Corp | Device for artificial kidney, quality evaluating device using the same and fluid circuit |
| JP4596171B2 (en) * | 2006-04-28 | 2010-12-08 | 東洋紡績株式会社 | Blood purifier |
| DE102012025052A1 (en) * | 2012-12-20 | 2014-06-26 | Fresenius Medical Care Deutschland Gmbh | Hämodiafiltrationsverfahren |
-
2021
- 2021-12-10 TR TR2021/019595A patent/TR2021019595A2/en unknown
- 2021-12-11 WO PCT/TR2021/051393 patent/WO2023107019A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023107019A1 (en) | 2023-06-15 |
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