TR2021015961A2 - A NEW HYDROJEL WITH GALANGIN - Google Patents
A NEW HYDROJEL WITH GALANGINInfo
- Publication number
- TR2021015961A2 TR2021015961A2 TR2021/015961A TR2021015961A TR2021015961A2 TR 2021015961 A2 TR2021015961 A2 TR 2021015961A2 TR 2021/015961 A TR2021/015961 A TR 2021/015961A TR 2021015961 A TR2021015961 A TR 2021015961A TR 2021015961 A2 TR2021015961 A2 TR 2021015961A2
- Authority
- TR
- Turkey
- Prior art keywords
- hydrogel
- galangin
- galangal
- feature
- cyclodextrin
- Prior art date
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- VCCRNZQBSJXYJD-UHFFFAOYSA-N galangin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=CC=C1 VCCRNZQBSJXYJD-UHFFFAOYSA-N 0.000 title claims abstract description 68
- CIPSYTVGZURWPT-UHFFFAOYSA-N galangin Natural products OC1=C(Oc2cc(O)c(O)cc2C1=O)c3ccccc3 CIPSYTVGZURWPT-UHFFFAOYSA-N 0.000 title claims abstract description 35
- SUYJZKRQHBQNCA-UHFFFAOYSA-N pinobanksin Natural products O1C2=CC(O)=CC(O)=C2C(=O)C(O)C1C1=CC=CC=C1 SUYJZKRQHBQNCA-UHFFFAOYSA-N 0.000 title claims abstract description 35
- 239000000017 hydrogel Substances 0.000 claims abstract description 51
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 17
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 16
- 229960004853 betadex Drugs 0.000 claims abstract description 16
- 238000004519 manufacturing process Methods 0.000 claims abstract description 16
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 15
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 15
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 15
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 15
- 239000001110 calcium chloride Substances 0.000 claims abstract description 15
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 15
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 15
- 239000000661 sodium alginate Substances 0.000 claims abstract description 15
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 15
- 235000011148 calcium chloride Nutrition 0.000 claims abstract description 11
- 239000002537 cosmetic Substances 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 5
- 235000013305 food Nutrition 0.000 claims abstract description 5
- 229960002713 calcium chloride Drugs 0.000 claims abstract 2
- 244000062241 Kaempferia galanga Species 0.000 claims description 34
- 235000013421 Kaempferia galanga Nutrition 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000000284 extract Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 235000019441 ethanol Nutrition 0.000 claims description 7
- 238000005538 encapsulation Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 238000000746 purification Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 abstract description 4
- 229920000615 alginic acid Polymers 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 241000013298 Alpinia <beetle> Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 230000002790 anti-mutagenic effect Effects 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229940124600 folk medicine Drugs 0.000 description 1
- -1 galangin compound Chemical class 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
Buluş, kozmetik, gıda ve tıp alanlarında kullanılan, galangin içeriği bakımından yüksek havlıcan bitkisini içeren bir hidrojel ve üretim yöntemi ile ilgilidir. Buluş özellikle, galangin içeriği bakımından yüksek havlıcan bitkisi, sodyum aljinat, beta-siklodekstrin ve kalsiyum klorür içeren bir galangin-aljinat hidrojeliyle ilgilidir.The invention relates to a hydrogel used in the fields of cosmetics, food and medicine, containing the galangin plant with high galangin content, and a production method. In particular, the invention relates to a galangin-alginate hydrogel containing galangin, sodium alginate, beta-cyclodextrin and calcium chloride high in galangin content.
Description
TARIFNAME GALANGIN IÇEREN YENI BIR HIDROJEL Teknik Alan Bulus, kozmetik, gida ve tip alanlarinda kullanilan, galangin içerigi bakimindan yüksek havlican bitkisini içeren bir hidrojel ve üretim yöntemi ile ilgilidir. DESCRIPTION A NEW HYDROJEL CONTAINING GALANGIN Technical Area High in galangin content, used in the fields of invention, cosmetics, food and medicine. It relates to a hydrogel containing the galangal plant and its production method.
Bulus özellikle, galangin içerigi bakimindan yüksek havlican bitkisi, sodyum aljinat, beta- siklodekstrin ve kalsiyum klorür içeren bir galangin-aljinat hidrojeliyle ilgilidir. In particular, galangal plant high in galangin content, sodium alginate, beta- It relates to a galangin-alginate hydrogel containing cyclodextrin and calcium chloride.
Teknigin Bilinen Durumu Hidrojel, birbirine çapraz bagli polimerlerin olusturdugu büyük karmasik ve suda çözünmeyen yapilardir. Sulu ortamlarda suyun bir kismini yapi içerisinde tutarak siser, dolayisiyla kütle ve hacmi dogru oranda artar. Dogal ve sentetik olarak bulunabilirler. State of the Art The hydrogel is a large complex of cross-linked polymers and are insoluble structures. In aqueous environments, it swells by keeping some of the water in the structure, therefore, its mass and volume increase in the right proportion. They can be found naturally and synthetically.
Yapisindaki çapraz baglar ag yapisini ve fiziksel bütünlügü saglarlar. The crosslinks in its structure provide the network structure and physical integrity.
Günümüzde hidrojellerin kullanim alanlari önem kazanmistir. Hidrojeller pek çok alanda kullanilmakla birlikte, özellikle antioksidan madde salinimi konusunda da kullanilmaktadir. Today, the usage areas of hydrogels have gained importance. Hydrogels in many fields Although it is used, it is also used especially for the release of antioxidant substances.
Antioksidan madde kaynagi farkli dogal, sentetik ürünler, dogal kaynakli (bitkisel ve meyve kökenli) ekstraktlar olabilir. Istenilen antioksidan maddeyi içeren hidrojellerin kullanimi, uygulama alaninda kontrollü salinimi sagladigi için avantaj kazanmaktadir. The source of antioxidants is different natural, synthetic products, naturally sourced (vegetable and fruit origin) extracts. Hydrogels containing the desired antioxidant substance Its use gains an advantage as it provides controlled release in the application area.
Literatürde, konu ile ilgili asagidaki basvurulara rastlanmistir: CN111110814 A numarali Çin patent basvurusu, kozmetik alaninda kullanilmak üzere, yara izi giderici bilesimi ve söz konusu bilesimin hazirlama yöntemini açiklamaktadir. Bu dokümanda yara giderici bilesim içeriginde galangin bulundugu ve hidrojel formunda olabilecegi ifade edilmektedir. Ancak, söz konusu dokümanda, havlican içerigine yönelik herhangi bir açiklama mevcut degildir. sistemine yönelik yöntemleri ile ilgilidir. Söz konusu dokümanda, antioksidan olarak galangin bileseninden bahsedilmekte ve salim sisteminin hidrojel formunda olabilecegi belirtilmektedir. Ancak, havlican içerigine yönelik herhangi bir açiklama mevcut degildir. In the literature, the following references on the subject have been found: Chinese patent application CN111110814 A, for use in the field of cosmetics, discloses the scar removing composition and the method of preparation of said composition. This In the document, the wound healing compound contains galangin and is in hydrogel form. is stated to be possible. However, in the document in question, the content of galangal no explanation available. related to the methods for the system. In the document in question, as an antioxidant The galangin component is mentioned and the release system may be in hydrogel form. is indicated. However, there is no explanation for the content of galangal.
Sonuç olarak yukarida anlatilan olumsuzluklardan dolayi ve mevcut çözümlerin konu hakkindaki yetersizligi nedeniyle ilgili teknik alanda bir gelistirme yapilmasi gerekli kilinmistir. As a result, due to the above-mentioned negativities and existing solutions It is necessary to make an improvement in the relevant technical field due to the inadequacy of the is locked.
Bulusun Kisa Açiklamasi Mevcut bulus, yukarida bahsedilen gereksinimleri karsilayan, tüm dezavantajlari ortadan kaldiran ve Ilave bazi avantajlar getiren yeni bir hidrojel ve üretim yöntemi ile ilgilidir. Brief Description of the Invention The present invention satisfies the above-mentioned requirements, eliminates all disadvantages. It relates to a new hydrogel and production method that lifts and brings some additional advantages.
Bulusun öncelikli amaci, galangin içerigi yüksek saf havlican ekstrakt kalintisi ile aljinat hidrojel hazirlamaktir. The primary aim of the invention is to produce pure galangal extract residue with high galangin content and alginate. to prepare a hydrogel.
Bulusun bir amaci, suda çözünmeyen ve biyolojik degeri yüksek galangin bilesiginin uygulanabilirligi veya kullanilabilirligini artirmaktir. One object of the invention is to produce a water-insoluble and high biological value galangin compound. to increase its applicability or usability.
Bulusun bir diger amaci, dogal havlican bitkisinin bir hidrojel üretiminde kullanilmasidir. Another object of the invention is to use the natural galangal plant in the production of a hydrogel.
Yukarida anlatilan amaçlarin yerine getirilmesi için, bulus konusu hidrojel galangin içerigi bakimindan yüksek bir havlican bitkisini ihtiva etmektedir. In order to fulfill the above-described purposes, the hydrogel galangin content of the invention is It contains a high galangal plant in terms of
Bulusun yapisal ve karakteristik özellikleri ve tüm avantajlari asagida yazilan detayli açiklama sayesinde daha net olarak anlasilacaktir ve bu nedenle degerlendirmenin de detayli açiklama göz 'önüne alinarak yapilmasi gerekmektedir. The structural and characteristic features of the invention and all its advantages are detailed below. It will be understood more clearly by the explanation and therefore the evaluation is also detailed explanation should be taken into consideration.
Bulusun Detayli Açiklamasi Bu detayli açiklamada bulus konusu hidrojel ve 'üretim yöntemi sadece konunun daha iyi anlasilmasina yönelik olarak ve hiçbir sinirlayici etki olusturmayacak sekilde açiklanmaktadir. Detailed Description of the Invention In this detailed description, the inventive hydrogel and its method of production are only better suited to the subject. for understanding and without any limiting effect is explained.
Bulus, kozmetik, gida ve tip alanlarinda kullanilan, galangin içerigi bakimindan yüksek havlican bitkisini içeren bir hidrojeldir. High in galangin content, used in the fields of invention, cosmetics, food and medicine. It is a hydrogel containing the galangal plant.
Bulusun tercih edilen bir uygulamasina göre; söz konusu hidrojel ek olarak sodyum aljinat, kitosan ve/veya nisasta içermektedir. Tercihen, sodyum aljinat içermektedir. According to a preferred embodiment of the invention; sodium alginate in addition to said hydrogel, Contains chitosan and/or starch. Preferably, it contains sodium alginate.
Bulus konusu hidrojel; ek olarak beta-siklodekstrin ve kalsiyum klorür içermektedir. The subject of the invention is the hydrogel; In addition, it contains beta-cyclodextrin and calcium chloride.
Bulus konusu hidrojel; havlican bitkisi, sodyum aljinat, beta-siklodekstrin ve kalsiyum klorür içermektedir. The subject of the invention is the hydrogel; galangal, sodium alginate, beta-cyclodextrin and calcium Contains chloride.
Bulus konusu hidrojel tercihen; agirlikca % 0,6-5 arasinda havlican bitkisi, % 0,6-5 sodyum aljinat, % 53-93 beta-siklodekstrin ve % 20-60 kalsiyum klorür içermektedir. The hydrogel of the invention is preferably; 0.6-5% galangal plant by weight, 0.6-5% It contains sodium alginate, 53-93% beta-cyclodextrin and 20-60% calcium chloride.
Bulus konusu hidrojel özellikle tercihen; agirlikça ortalama % 3,5 havlican bitkisi, % 3,5 sodyum aljinat, °/o 73 beta-siklodekstrin ve % 20 kalsiyum klorür içermektedir. The hydrogel of the invention is particularly preferably; Average 3.5% galangal plant by weight, 3.5% sodium alginate, °/o 73 beta-cyclodextrin and 20% calcium chloride.
Bu bulus, galangin içerigi bakimindan yüksek havlican bitkisinin bir hidrojel üretiminde kullanimini da kapsamaktadir. This invention is based on the production of a hydrogel of galangal plant high in galangin content. includes its use.
Bulus konusu hidrojel üretim yöntemi asagidaki islem basamaklarini içermektedir: i. havlican bitkisinin ekstrakte edilmesi, ii. elde edilen havlican ekstraktindan galanginin saflastirilmasi, iii. galanginin beta-siklodekstrin ile enkapsülasyonu, iv. kalsiyum klorür ve diger yardimci maddeler eklenerek hidrojelin elde edilmesi. The hydrogel production method, which is the subject of the invention, includes the following processing steps: I. extracting the galangal plant, ii. Purification of galangin from the obtained galangal extract, iii. encapsulation of galangin with beta-cyclodextrin, iv. Obtaining the hydrogel by adding calcium chloride and other excipients.
Bulusun tercih edilen bir uygulamasina göre; (i) islem adiminda havlican bitkisi üzerine su ve etil alkol eklenerek, bir karistiricida ortalama 4 saat süresince ve 10°Cide ekstrakte edilmektedir. According to a preferred embodiment of the invention; (i) water on the galangal plant in the treatment step and ethyl alcohol is added and extracted in a mixer at 10°C for an average of 4 hours. is being done.
Bulusun tercih edilen bir uygulamasina göre; (ii) islem adiminda havlican ekstraktinin bir dolgu materyali ve organik çözücü yardimiyla kolondan geçirilerek saflastirilmaktadir. According to a preferred embodiment of the invention; (ii) in the processing step, a mixture of galangal extract It is purified by passing through the column with the help of filling material and organic solvent.
Bulusun tercih edilen bir uygulamasina göre; (iii) islem adiminda galanginin bir magnetik karistiricida ortalama 50 °C sicaklikta çözücüsü tamamen uçuncaya kadar beta- siklodekstrin ile karistirilarak enkapsüle edilmektedir. According to a preferred embodiment of the invention; (iii) in the processing step galangin is a magnetic in the mixer at an average temperature of 50 °C until the solvent evaporates completely. It is encapsulated by mixing with cyclodextrin.
Bulusun tercih edilen bir uygulamasina göre; (iii) islem adiminda kalsiyum klorür ve sodyum aljinat eklenmektedir. According to a preferred embodiment of the invention; (iii) calcium chloride and sodium alginate is added.
Asagidaki Tablo-1ide galangin içerikli 'Örnek bir hidrojel kompozisyonu gösterilmektedir: Içerik Agirlikça Agirlikça Tercih edilen Kullanilabilir Miktar Miktar Havlican 0/0 355 %0,8-%5 Beta-siklodekstrin % 3,5 %0,6-%5 Sodyum aljinat % 73 %53-%93 Kalsiyum klorür % 20 %20- %60 Tablo-1: Bulus konusu örnek bir hidrojel kompozisyonu Uretim basamaklarinda galangin-beta siklodekstrin enkapsülasyon isleminde etil alkol ortamdan uzaklastirilir. Bu sebeple son üründeki hidrojel olusumunda etil alkol bulunmamaktadir. Table-1 below shows an 'Example hydrogel composition containing galangin: Content by Weight By Weight Preferred Available Quantity Quantity Galangal 0/0 355 0.8%-5% Beta-cyclodextrin 3.5% 0.6-5% Sodium alginate 73% 53%-93% Calcium chloride 20% 20%-60% Table-1: An exemplary hydrogel composition of the invention Ethyl alcohol in the galangin-beta cyclodextrin encapsulation process in the production steps removed from the environment. For this reason, ethyl alcohol is used in hydrogel formation in the final product. does not exist.
Hidrojel olusumunda havlican (Alpinia officinarium) bitkisinin etanol ortaminda hazirlanip saflastirilan ekstrakti kullanilmaktadir. Havlican bitkisinde galangin bilesigi temel bilesen olarak bulunmaktadir. Galangin zayif asidik özellige sahip ve suda çözünmeyen bir bilesiktir. Diyabet, ishal, öksürük, mide ve bagirsak hastalarinda kullanilan halk ilaci olarak bilinmektedir. Kimyasal yapisina bakildiginda antimutajenik, enzim düzenleyici ve Asagida bulus konusu üründe kullanilan hammaddelerin fonksiyonlari verilmistir: Havlican: Galangin içerigi yüksek dogal kaynaktir. In hydrogel formation, galangal (Alpinia officinarium) plant is prepared in ethanol medium. The purified extract is used. The main component of galangin in galangal plant exists as. Galangin is a weakly acidic and water-insoluble is compound. As a folk medicine used in patients with diabetes, diarrhea, cough, stomach and intestines. known. Considering its chemical structure, it is antimutagenic, enzyme regulator and The functions of the raw materials used in the product subject of the invention are given below: Galangal: It is a natural resource with a high content of galangin.
EtiI alkol: Galangin çözünürlügü ve ektrakt hazirlanmasi için önemlidir. Ethyl alcohol: It is important for the solubility of galangin and for the preparation of the extract.
Galangin: Antioksidan özelligi olan hidrojel olusumda temel bilesendir. Galangin: It is the basic component in hydrogel formation with antioxidant properties.
Beta-siklodekstrin: Suda çözünürlügü az olan galanginin enkapsülasyon ile çözünürlügünün artmasi saglanir. Beta-cyclodextrin: By encapsulation of galangin, which is less soluble in water. resolution is increased.
Sodyum aljinat: Hidrojel olusumu için gereklidir. Sodium alginate: Necessary for hydrogel formation.
Kalsiyum klorür: Hidrojellerin olusturulmasi için kullanilir. Calcium chloride: It is used to form hydrogels.
Bulus konusu üretim yöntemi asagida ayrintili olarak açiklanmaktadir: i. Havlican ekstraktinin eldesi: g havlican bitkisi tartilir. Üzerine 20 ml su, 80 ml etil alkol ilave edilir. Karistiricida 4 saat boyunca agzi kapali olacak sekilde 10°C'de ekstrakte edilir. Süzgeç kagidi ile li. Galangin saflastirilmasi: Havlican ekstraktindan 10 mL alinir, içinde 5 g Sephadex LH-20 dolgu materyali olan kolondan geçirilir. Daha sonra kolona 100 mL organik çözücü eklenir. Elde edilen eluatlar birlestirilir. iii. Galanginin beta-siklodekstrin ile enkaps'ülasyonu 2,0630 g ß-siklodekstrin tartilir. Uzerine 100 ml havlican etanol ekstrakti eklenir. Magnetik karistiricida 50 °C sicakliginda çözücüs'u tamamen uçuncaya kadar karistirilir. Elde edilen kalinti hidrojel olusumunda kullanilir. iv. Galangin-aljinat hidrojelinin hazirlanisi eklenir ve karistirilir. 50 mL %1 (v/w) CaCIz çözeltisi 125 rpm°de magnet ile karistirilirken Damlatma islemi bittiginde 125 rpm hizinda yaklasik 43,55 dk daha karistirilir. Adi süzgeç kagidinda süzül'ür, hidrojeller 20 mL saf su ile yikanir. Süz'ülen hidrojeller kurutulmaya birakilir. The production method of the invention is explained in detail below: I. Obtaining galangal extract: g galangal plant is weighed. Add 20 ml of water and 80 ml of ethyl alcohol. 4 in mixer It is extracted at 10°C with the mouth closed for an hour. with filter paper li. Purification of galangin: Take 10 mL of galangal extract, containing 5 g of Sephadex LH-20 filling material. passed through the column. Then 100 mL of organic solvent is added to the column. The eluates obtained are combined. iii. Encapsulation of galangin with beta-cyclodextrin 2.0630 g of ß-cyclodextrin are weighed. 100 ml of galangal ethanol extract is added to it. magnetic It is mixed in a mixer at a temperature of 50 °C until the solvent is completely evaporated. Obtained used in the formation of residual hydrogel. iv. Preparation of galangin-alginate hydrogel added and mixed. While stirring 50 mL 1% (v/w) CaCl2 solution with magnet at 125 rpm When the dripping process is finished, it is mixed for approximately 43.55 minutes at 125 rpm. Ordinary strainer filtered on paper, the hydrogels are washed with 20 mL of distilled water. The filtered hydrogels were dried. is left.
Bulusun üretim yöntemi sirasinda dikkat edilmesi gereken noktalar asagida belirtilmistir: - Hazirlanan havlican ekstraktinda galangin çözünürlügünün yüksek verimle elde edilmesi için sicaklik, zaman ve karistirma hizi önemlidir. The points to be considered during the production method of the invention are given below: - Galangin solubility is obtained in high yield in the prepared galangal extract. temperature, time and mixing speed are important.
- Galangin saflastirilmasinda yeterince dolgu materyali ve derisik ekstrakt kullanilmasi Önemlidir. - Sufficient filler material and leathery extract for purification of galangin It is important to use.
- Galangin enkaps'ulasyonunda çözücün'un tamamen uzaklastirilmasi önemlidir. - It is important that the solvent is completely removed in the encapsulation of galangin.
- Hidrojel olusumunda eklenecek maddelerin sirasi ve kullanilacak enjektör ucu hidrojel boyutu için önemlidir. - The order of the substances to be added in hydrogel formation and the injector tip to be used important for hydrogel size.
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