TR202020960A2 - A SYSTEM AND METHOD THAT PROVIDES DATA EXCHANGE BETWEEN NANO ELEMENTS ON THE BODY AND OUTSIDE MACRO/MICRO ELEMENTS - Google Patents

A SYSTEM AND METHOD THAT PROVIDES DATA EXCHANGE BETWEEN NANO ELEMENTS ON THE BODY AND OUTSIDE MACRO/MICRO ELEMENTS

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Publication number
TR202020960A2
TR202020960A2 TR2020/20960 TR202020960A2 TR 202020960 A2 TR202020960 A2 TR 202020960A2 TR 2020/20960 TR2020/20960 TR 2020/20960 TR 202020960 A2 TR202020960 A2 TR 202020960A2
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TR
Turkey
Prior art keywords
feature
antenna
exposed
electromagnetic signal
reformable
Prior art date
Application number
TR2020/20960
Other languages
Turkish (tr)
Inventor
Dumanli Oktar Sema
Original Assignee
Boğazi̇çi̇ Üni̇versi̇tesi̇
Filing date
Publication date
Application filed by Boğazi̇çi̇ Üni̇versi̇tesi̇ filed Critical Boğazi̇çi̇ Üni̇versi̇tesi̇
Priority to JP2022536705A priority Critical patent/JP2023507124A/en
Priority to PCT/TR2020/051338 priority patent/WO2021126135A1/en
Priority to US17/785,936 priority patent/US20230027600A1/en
Publication of TR202020960A2 publication Critical patent/TR202020960A2/en

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Abstract

Buluş, beden içerisindeki veyahut üzerindeki nano elemanlardan (300) veri almak için bir sistemdir. Buna göre, beden içinden beden dışına veri aktarmak üzere beden içine veyahut üzerindeki yerleştirilmek için bir anteni; (110) bahsedilen antenin (110) elektromanyetik sinyale maruz kaldığında, elektromanyetik sinyali yansıtacak şekilde konfigüre edilmiş bir anten gövdesini (111) içeren bir moleküler haberleşme birimini (100) içermesi ve bahsedilen anten gövdesinin (111) beden içinde bir etmene maruz kaldığında formunu değiştiren bir materyalden imal edilmiş bir yeniden şekillendirilebilir kısımnı (112) içermesiyle karakterize edilmektedir. Şekil 1The invention is a system for receiving data from nano elements (300) in or on the body. Accordingly, an antenna to be placed inside or on the body to transmit data from inside the body to outside the body; (110) includes a molecular communication unit (100) that includes an antenna body (111) configured to reflect the electromagnetic signal when the said antenna (110) is exposed to an electromagnetic signal, and said antenna body (111) has a structure that changes its form when exposed to a factor within the body. It is characterized by containing a reshapeable part (112) made of material. Figure 1

Description

TARIFNAME BEDEN ÜZERINDEKI NANo ELEMANLAR iLE BEDEN DISI MAKRoiMiKRo ELEMANLAR ARASINDA VERI ALISVERISINI SAGLAYAN BIR SISTEM VE YÖNTEM TEKNIK ALAN Bulus, beden içi veyahut üzerindeki nano elemanlar ile beden disi veya içi makro/mikro elemanlar arasinda veri alisverisini saglayan, moleküler nano iletisim agindan beden alan agina veri aktarmaya yarayan bir sistem ve söz konusu sistemin uyguladigi bir yöntem ile ÖNCEKI TEKNIK Beden içerisindeki nano makine, nano ilaç, bakteri gibi nano elemanlar birbirleriyle haberci moleküller vasitasiyla haberlesmektedir. EP1850513B1 numarali EPO basvurusunda birbirleriyle moleküller vasitasiyla haberlesen nano makinalar açiklanmaktadir. Beden içerisindeki olaylarin anlik olarak izlenebilmesi için nano elemanlarin beden disindaki bir cihaz ile haberlesebilmesi gerekmektedir. Beden içerisindeki nano elemanlarin beden disindaki cihazlarla haberlesmesi teshis, tedavi ve algilama amaçlariyla kullanilabilecektir. Mevcut teknikte, nano-sensöre sahip olan ve nano sensörden aldigi veriyi bir anten vasitasiyla beden disindaki bir dis haberlesme birimine (örnegin bir Beden Alan Agina (BAN)) gönderen araci cihazlar bilinmektedir. L. Felicetti ve digerlerinin "Applications of molecular communications to medicine:A survey, "Nano Communication Networks 7 (2016) 27-45 dokümaninda damardaki nano elemanlar ile beden disi haberlesme birimi arasinda veri alisverisini saglamak için nano elemanlarin kullandigi haberci molekülleri algilayan bir nanosensörü ve nanosensörden alinan veriyi isleyen bir islemci ve islemciden veriyi almak üzere damar içerisine sokulan bir probu içeren bir yöntemden bahsedilmektedir. Ancak bu yöntem hem diger dokulardaki nano elemanlarla haberlesmek için uygun degildir hem de veri alinmak istendiginde damara prob sokulmasini gerektirmektedir. TR TR TR DESCRIPTION A SYSTEM AND METHOD THAT PROVIDES DATA EXCHANGE BETWEEN NANO ELEMENTS ON THE BODY AND OUT-BODY MACRO-MICRO ELEMENTS TECHNICAL FIELD The invention provides data exchange between nano elements in or on the body and macro/micro elements outside or inside the body, data from the molecular nano communication network to the body field network. BACKGROUND: Nano elements within the body, such as nano machines, nano drugs and bacteria, communicate with each other through messenger molecules. In the EPO application numbered EP1850513B1, nano machines that communicate with each other through molecules are described. In order to instantly monitor the events within the body, nanoelements must be able to communicate with a device outside the body. The communication of nanoelements inside the body with devices outside the body can be used for diagnosis, treatment and detection purposes. In the current technique, intermediary devices are known that have a nano-sensor and send the data received from the nano-sensor to an external communication unit outside the body (for example, a Body Area Network (BAN)) via an antenna. In the document "Applications of molecular communications to medicine: A survey, "Nano Communication Networks 7 (2016) 27-45, L. Felicetti et al. describe a nanosensor that detects the messenger molecules used by the nanoelements to ensure data exchange between the nanoelements in the vein and the extracorporeal communication unit. A method is mentioned that includes a processor that processes the data received from the nanosensor and a probe inserted into the vein to receive the data from the processor. However, this method is not suitable for communicating with nanoelements in other tissues and requires insertion of a probe into the vein when data is desired to be obtained. TR TR TR

Claims (1)

1.ISTEMLER Beden üzerindeki nano elemanlardan (300) veri almak için bir sistem olup özelligi; moleküler nano iletisim agindan beden alan agina veri aktarmak üzere beden üzerine yerlestirmek için bir anteni (110) bahsedilen antenin (110) elektromanyetik sinyale maruz kaldiginda, elektromanyetik sinyali degistirerek yansitacak sekilde konfigüre edilmis bir anten gövdesini (111) içeren bir moleküler haberlesme birimini (100) içermesi ve bahsedilen anten gövdesinin (111) beden üzerinde bir etmene maruz kaldiginda formunu degistiren bir materyalden imal edilmis bir yeniden sekillendirilebilir kismini (112) içermesidir. Istem 1'e göre bir sistem olup özelligi; antene (110) elektromanyetik sinyal göndermek ve antenin (110) yansittigi elektromanyetik sinyali almak için bir alici/vericiye (220), bahsedilen alici/vericinin (220) antene (110) elektromanyetik sinyal göndermesini kontrol edecek ve alici/vericiden (220) alinan elektromanyetik sinyali alacak sekilde konfigüre edilmis bir islemci birimine (210) sahip olan ve bahsedilen islemci biriminin (210) antenden (110) alinan elektromanyetik sinyalin en az bir karakteristik özelligine göre beden üzerindeki bir bölgeden bir etmene maruz kaldigini belirleyecek sekilde konfigüre edilmis oldugu bir diger haberlesme birimini (200) içermesidir. Istem 1'e göre bir sistem olup özelligi; bahsedilen anten gövdesinin (111) tamaminin yeniden sekillendirilebilir kisim (112) olmasidir. Istem 1'e göre bir sistem olup özelligi; beden üzerinde bir etmene maruz kaldiginda formunu degistiren bahsedilen materyalin biyoçözünür materyal olmasidir. Istem 4'e göre bir sistem olup özelligi; yeniden sekillendirilebilir kismin (112) en azindan kismen saracak sekilde saglanmis bir biyofilmi (120) içermesidir. Istem 5'e göre bir sistem olup özelligi; yeniden sekillendirilebilir kisminin bir birinci maddeye (122) maruz kaldiginda biyoçözünme hizi artan bir materyali içermesidir. Istem 6'ya göre bir sistem olup özelligi; haberci moleküle (310) maruz kaldiginda birinci maddeyi(122) üreten biyofilmi (120) üreten, bir genetigi degistirilmis mikroorganizmayi (121) içermesidir. Istem 7'ye göre bir sistem olup özelligi; bahsedilen birinci maddenin (122) asidik asit olmasidir. Istem 8”e göre bir sistem olup özelligi; bahsedilen haberci molekülün (310) bir bakteri enfeksiyonuna iliskin quorum algilama molekülü olmasi ve genetigi degistirilmis mikroorganizmanin (121) sözü edilen quorum algilama molekülüne maruz kalinca birinci madde (122) olarak asidik asit üreten Koli Basili susu olmasidir. . Istem 1'e göre bir sistem olup özelligi; bahsedilen biyoçözünür materyalin polimer, magnezyum, demir ve çift katmanli çinko/demir arasindan seçilmis olmasidir. Istem 4'e göre bir sistem olup özelligi; yeniden sekillendirilebilir kisminin (112) çözünme hizini yavaslatmak için anteni (110) en azindan kismen saracak sekilde saglanmis en az bir sübstrati (130) içermesidir. Istem 11”e göre bir sistem olup özelligi; bahsedilen sübstratin (130) biyoçözünür materyal içermesidir. Istem 12”ye göre bir sistem olup özelligi; bahsedilen sübstratin (130), poligliserol sebasat, polioktametilen meleat (anhidrit) sitrat, polilaktikasit, poli(laktik-ko-glikolik asit) ve ipekten en az birini içermesidir. .Istem 12”ye göre bir sistem olup özelligi; anteni (110) arasina alacak sekilde iki sübstratin (130) saglanmis olmasidir. Istem 1'e göre bir sistem olup özelligi; bahsedilen yeniden sekillendirilebilir kisminin (112) önceden belirlenmis bir esik degerini asan bir kuvvete maruz kaldiginda esneyecek sekilde konfigüre edilmis olmasidir. Istem 15”e göre bir sistem olup özelligi; bir haberci moleküle (310) maruz kaldiginda kasilip yeniden sekillendirilebilir kismina (112) kuvvet uygulayarak yeniden sekillendirilebilir kisminin (112) deforme olmasini saglayan yeniden sekillendirilebilir kisim (112) ile iliskili bir genetigi degistirilmis dokuyu (140) içermesidir. Istem 16'ya göre bir sistem olup özelligi; bahsedilen genetigi degistirilmis dokunun (140) kas doku olmasidir. Istem 2'ye göre bir sistem olup özelligi; bahsedilen karakteristik özelligin frekans olmasidir. Istem 2'ye göre bir sistem olup özelligi; diger haberlesme biriminin (200), islemci birimi (210) tarafindan veri okuma yapmasina izin verecek sekilde islemci birimiyle (210) iliskili olarak saglanmis bir hafiza birimini (230) içermesi; islemci biriminin (210), antenden (110) alinan sinyaldeki karakteristik özellikler ile hafiza birimindeki (230) en az bir referans karakteristik özellikten yaptigi sapmaya göre antenin (110) beden üzerindeki bölgeden bir etmene maruz kaldigini belirleyecek sekilde konfigüre edilmis olmasidir. Istem 2'ye göre bir sistem olup özelligi; diger haberlesme biriminin (200), islemci biriminin (210) antenin (110) beden üzerindeki bölgeden bir etmene maruz kaldigina iliskin bir çikisi yapmasini saglayan bir giris çikis birimini içermesidir. Istem 2'ye göre bir sistem olup özelligi; diger haberlesme biriminin (200) bir gövdeyi içermesi ve bahsedilen gövdenin beden üzerine yerlestirilmis olmasidir. Istem 4'e göre bir sistem olup özelligi; anten gövdesinin (111), bir birinci kismi bahsedilen birinci kisim (113) ile bir birinci yeniden sekillendirilebilir kisim (117) vasitasiyla baglantili bir ikinci kismi ve bahsedilen ikinci kisim (114) ile bir ikinci yeniden sekillendirilebilir kisim (118) vasitasiyla baglantili bir üçüncü kismi içermektedir. Istem 22'ye göre bir sistem olup özelligi; birinci yeniden sekillendirilebilir kisim (117) ve ikinci yeniden sekillendirilebilir kisminin (118) birbirinden farkli etmenlere maruz kaldiginda biyoçözünecek materyallerden imal edilmis olmasidir. TR TR TR1. CLAIMS It is a system for receiving data from nano elements (300) on the body and its feature is; a molecular communication unit (100) comprising an antenna (110) to place on the body to transfer data from the molecular nanocommunication network to the body field network, and an antenna body (111) configured to change and reflect the electromagnetic signal when said antenna (110) is exposed to the electromagnetic signal. and that said antenna body (111) contains a reconfigurable part (112) made of a material that changes its form when exposed to a factor on the body. It is a system according to claim 1 and its feature is; In order to send an electromagnetic signal to the antenna (110) and to receive the electromagnetic signal reflected by the antenna (110), a receiver/transmitter (220) is used to control the said receiver/transmitter (220) from sending the electromagnetic signal to the antenna (110) and the electromagnetic signal received from the receiver/transmitter (220). Another communication unit having a processor unit (210) configured to receive the signal and where said processor unit (210) is configured to determine whether a region on the body has been exposed to an agent based on at least one characteristic of the electromagnetic signal received from the antenna (110). It contains (200). It is a system according to claim 1 and its feature is; The entire said antenna body (111) is a reconfigurable part (112). It is a system according to claim 1 and its feature is; The said material, which changes its form when exposed to a factor on the body, is a biodegradable material. It is a system according to claim 4 and its feature is; The reformable portion (112) contains a biofilm (120) provided to at least partially surround it. It is a system according to claim 5 and its feature is; The reformable part contains a material whose biodegradation rate increases when exposed to a first substance (122). It is a system according to claim 6 and its feature is; It contains a genetically modified microorganism (121) that produces the biofilm (120) that produces the first substance (122) when exposed to the messenger molecule (310). It is a system according to claim 7 and its feature is; The first mentioned substance (122) is acidic acid. It is a system according to claim 8 and its feature is; The said messenger molecule (310) is the quorum sensing molecule related to a bacterial infection and the genetically modified microorganism (121) is the Coli strain that produces acidic acid as the first substance (122) when exposed to the said quorum sensing molecule. . It is a system according to claim 1 and its feature is; The said biodegradable material is chosen among polymer, magnesium, iron and double-layer zinc/iron. It is a system according to claim 4 and its feature is; The reformable part (112) contains at least one substrate (130) provided to at least partially surround the antenna (110) in order to slow down the dissolution rate. It is a system according to claim 11 and its feature is; said substrate (130) contains biodegradable material. It is a system according to claim 12 and its feature is; said substrate (130) contains at least one of polyglycerol sebacate, polyoctamethylene meleate (anhydride) citrate, polylactic acid, poly(lactic-co-glycolic acid) and silk. It is a system according to claim 12 and its feature is; Two substrates (130) are provided to hold the antenna (110) between them. It is a system according to claim 1 and its feature is; The said reformable part (112) is configured to flex when exposed to a force exceeding a predetermined threshold value. It is a system according to claim 15 and its feature is; It contains a genetically modified tissue (140) associated with the remouldable part (112), which causes the remouldable part (112) to deform by applying force to the remouldable part (112) by contracting when exposed to a messenger molecule (310). It is a system according to claim 16 and its feature is; The genetically modified tissue (140) mentioned is muscle tissue. It is a system according to claim 2 and its feature is; The characteristic feature mentioned is frequency. It is a system according to claim 2 and its feature is; the other communication unit (200) includes a memory unit (230) provided in association with the processor unit (210) to allow data reading by the processor unit (210); The processor unit (210) is configured to determine whether the antenna (110) is exposed to a factor from the region on the body, according to the characteristic features in the signal received from the antenna (110) and its deviation from at least one reference characteristic feature in the memory unit (230). It is a system according to claim 2 and its feature is; The other communication unit (200) contains an input and output unit that enables the processor unit (210) to make an output indicating that the antenna (110) is exposed to a factor from the area on the body. It is a system according to claim 2 and its feature is; The other communication unit (200) includes a body and said body is placed on the body. It is a system according to claim 4 and its feature is; The antenna body (111) has a first part connected to said first part (113) by means of a first reformable part (117), and a third part connected to said second part (114) by means of a second reformable part (118). Contains. It is a system according to claim 22 and its feature is; The first re-formable part (117) and the second re-formable part (118) are manufactured from materials that will biodegrade when exposed to different factors. TR TR TR
TR2020/20960 2019-12-20 2020-12-19 A SYSTEM AND METHOD THAT PROVIDES DATA EXCHANGE BETWEEN NANO ELEMENTS ON THE BODY AND OUTSIDE MACRO/MICRO ELEMENTS TR202020960A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022536705A JP2023507124A (en) 2019-12-20 2020-12-21 Systems and methods for providing wireless communication between bio-nanoelements in or on the body and macro/micro devices outside or inside the body
PCT/TR2020/051338 WO2021126135A1 (en) 2019-12-20 2020-12-21 A system and method which provides wireless communication between bio-nano elements and macro/micro devices
US17/785,936 US20230027600A1 (en) 2019-12-20 2020-12-21 System and method which provides wireless communication between bio-nano elements and macro/micro devices

Publications (1)

Publication Number Publication Date
TR202020960A2 true TR202020960A2 (en) 2023-05-22

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