TR202015642A2 - VASCULAR CLAMP - Google Patents
VASCULAR CLAMP Download PDFInfo
- Publication number
- TR202015642A2 TR202015642A2 TR2020/15642A TR202015642A TR202015642A2 TR 202015642 A2 TR202015642 A2 TR 202015642A2 TR 2020/15642 A TR2020/15642 A TR 2020/15642A TR 202015642 A TR202015642 A TR 202015642A TR 202015642 A2 TR202015642 A2 TR 202015642A2
- Authority
- TR
- Turkey
- Prior art keywords
- feature
- vascular
- microcatheter
- plug
- plug according
- Prior art date
Links
- 230000002792 vascular Effects 0.000 title claims abstract description 29
- 230000000740 bleeding effect Effects 0.000 claims abstract description 21
- 210000001724 microfibril Anatomy 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 8
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 7
- 239000007787 solid Substances 0.000 claims abstract description 3
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims description 5
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 5
- 229920001410 Microfiber Polymers 0.000 claims description 4
- 239000003658 microfiber Substances 0.000 claims description 4
- -1 polyglactin Substances 0.000 claims description 4
- 229920000742 Cotton Polymers 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 229920000954 Polyglycolide Polymers 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000002729 catgut Substances 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 239000002872 contrast media Substances 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- NLCKLZIHJQEMCU-UHFFFAOYSA-N cyano prop-2-enoate Chemical class C=CC(=O)OC#N NLCKLZIHJQEMCU-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 2
- 239000000622 polydioxanone Substances 0.000 claims description 2
- 239000004633 polyglycolic acid Substances 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
- 238000002697 interventional radiology Methods 0.000 abstract description 4
- 208000032843 Hemorrhage Diseases 0.000 description 20
- 206010002329 Aneurysm Diseases 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 241000282465 Canis Species 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000003327 cancerostatic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000010102 embolization Effects 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 108700005457 microfibrillar Proteins 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000002121 nanofiber Substances 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/12031—Type of occlusion complete occlusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12159—Solid plugs; being solid before insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
Abstract
Buluş, girişimsel radyoloji alanında kan damarlarının tıkanması ve kanamanın durdurulması için çeşitli çaplarda mikrokateterlerin (3) iç boşluğundan kılavuz tel (2) ile itilerek, mikrokateterin (3) distal ucundan ilgili damar lümenine (5) serbestlenen vasküler tıkaca (1) ilişkindir. Söz konusu tıkaç biyoemilimli ya da biyouyumlu mikrofibrillerin bir monofilament (monoflaman)iplik oluşturmak üzere bir araya getirilerek sertleştirilmesiyle üretilmiş olup radyo-opak materyali haizdir. Ön ucu sivri, gövde kesimi silindirik ve yekpare; kılavuz tel (2) ile itilen arka ucu (6) fırça şeklinde serbest mikrofibriller içermektedir. Kısa, düz ve boşluksuz iskelet yapısı ile kolay uygulanabilir, etkili ve düşük maliyetli bir tıkaçtır.The invention relates to the vascular plug (1) released from the distal end of the microcatheter (3) to the corresponding vascular lumen (5) by pushing with the guide wire (2) from the inner cavity of microcatheters (3) of various diameters in order to occlude blood vessels and stop bleeding in the field of interventional radiology. The plug is produced by stiffening bioabsorbable or biocompatible microfibrils together to form a monofilament thread and has a radio-opaque material. Its front end is pointed, body cut is cylindrical and solid; The rear end (6) pushed by the guide wire (2) contains free brush-shaped microfibrils. It is an easy-to-apply, effective and low-cost plug with its short, straight and gapless skeleton structure.
Description
TARIFNAME VASKÜLER TIKAÇ Bulusun Konusu Bulus, girisimsel radyoloji alaninda kan damarlarinin tikanmasi ve kanamanin durdurulmasi için çesitli Çaplarda mikrokateterlerin (3) iç boslugundan kilavuz tel (2) ile itilerek, mikrokateterin (3) distal ucundan ilgili damar lümenine (5) serbestlenen vasküler tikaca (l) iliskindir- Söz konusu tikaç biyoemilimli ya da biyouyumlu mikrofibrillerin bir monofilament (monoflaman)iplik olusturmak üzere bir araya getirilerek sertlestirilmesiyle üretilmis olup radyo-opak materyali haizdir. Ön ucu sivri, gövde kesimi silindirik ve yekpare; kilavuz tel (2) ile itilen arka ucu (6) firça seklinde serbest mikrofibriller içermektedir. Kisa, düz ve bosluksuz iskelet yapisi ile kolay uygulanabilir, etkili ve düsük maliyetli bir tikaçtir. DESCRIPTION VASCULAR PLUG Subject of the Invention The invention is used in the field of interventional radiology Various Diameters for blocking and stopping bleeding through the inner cavity of the microcatheters (3) with the guide wire (2). the relevant vessel from the distal end of the microcatheter (3). It is related to the vascular plug (l) released into its lumen (5). The plug in question consists of bioabsorbable or biocompatible microfibrils. together to form a monofilament (monofilament) thread. It is produced by bringing and hardening and is radio-opaque. has the material. The front end is pointed, the body cut is cylindrical and monolithic; rear end (6) brush pushed by guide wire (2) It contains free microfibrils. short, straight and It can be applied easily, effectively and efficiently with its gap-free skeletal structure. It is a low cost plug.
Teknigin Bilinen Durumu Girisimsel radyolojide kanamalari durdurmak, ilgili damarlara kan gitmesini engellemek ya da damar anevrizmalarinin ameliyatsiz, endovasküler yolla doldurulmasini saglamak için kateterlerden tasinan ve damar ya da anevrizma içinde serbestlendiginde sekil hafizasina göre yumaklanan vasküler tikaçlar (coils) kullanilmaktadir. Kanama ya da tümör embolizasyonlarinda, pratikte yine kateterlerden sivi içerisinde enjekte edilen çesitli mikron Çaplarda partiküller ya da partikül içermeyen sivi embolizan ajan uygulanmalari da mevcuttur. State of the Art Stopping bleeding in interventional radiology to prevent blood flow or to prevent vascular aneurysms to provide non-surgical, endovascular filling carried through catheters and in a vessel or aneurysm vascular flocculation according to shape memory when released plugs (coils) are used. Bleeding or tumor in embolizations, in practice, fluid from the catheters particles of various micron diameters injected in or application of a liquid embolizing agent that does not contain particles. available.
Koiller damar lümeni içinde arzu edilen konumda temel olarak iki sekilde serbestlenir; (pushable) ilerletilir ki bu tip koiller serbestlendiginde tekrar toplanamaz. 11. Bir tasiyici tele ilistirilmis koil mikrokateterden damar lümenine ön ucu serbestlendikten sonra verilen son karara göre çesitli mekanizmalar (electrolytic, mechanical, hydraulic, electrothermal) ile arka ucu telden ayrilir (detachable). Bunun avantaji, koilin konumu ya da boslukta aldigi sarmal halinin hatali oldugu düsünülüyor ise ilistirildigi tasiyici telden ayrilmadan mikrokateter içerisine tekrar toplanmasidir. The coils are basically located in the desired position within the vessel lumen. it is released in two ways; (pushable) is advanced so that when such coils are released cannot be collected again. 11. Vessel through a coil microcatheter attached to a carrier wire to the final decision made after the anterior end of its lumen has been released various mechanisms (electrolytic, mechanical, hydraulic, electrothermal) to separate the rear end from the wire (detachable). The advantage of this is the position of the coil or in the gap. if it is thought that the spiral state it takes is wrong microcatheter without detaching from the carrier wire to which it is attached. reassembly into it.
Vasküler tikaçlarda önceki teknige ait endovasküler koillerin geneli, istenilen çap ve uzunlukta mikrohelikal formda süperelastik metal alasim (nitinol vs.) iskeleti ve sekil hafizasi ile boslukta sarmal halini (makrohelikal, spiral ya da üç boyutlu kompleks) alarak damar içi kan akimini engeller ve kanamayi durdurulabilir. Anevrizma tedavisinde kullaniliyor ise anevrizma boslugu koiller ile doldurulur. Prior art endovascular coils in vascular plugs in general, in the desired diameter and length in microhelical form superelastic metal alloy (nitinol etc.) skeleton and shape spiral form in space (macrohelical, spiral or It also prevents intravascular blood flow by taking the three-dimensional complex and bleeding can be stopped. Aneurysm treatment If it is used, the aneurysm space is filled with coils.
Böylelikle artan kan basinciyla anevrizmanin daha fazla genisleyerek çeperinin yirtilmasinin ve olasi kanamanin önüne geçilmis olur. Bazi durumlardar çoklu koil kullanimi gerekebilir. Bazi koiller pihtilasmayi tetikleyen tüysü kisa fibriler eklentilere ya da su temasi durumunda sisen kaplamalara sahiptir. Thus, with increased blood pressure, the aneurysm becomes more It expands to prevent rupture of the wall and possible bleeding. it will be passed. In some cases, the use of multiple coils may be required. Some coils are short hairy that trigger coagulation. in case of contact with fibrillar attachments or water, It has coatings.
Vasküler tikaçlar, ameliyata gerek kalmaksizin ya da ameliyat yapilamayacak durumlarda acil kanamalari durdurmak için kullanilan çok faydali ürünlerdir. Ancak en önemli dezavantajlari kompleks yapili ve yüksek maliyetli olmalaridir. Vascular plugs, with or without the need for surgery in cases where it cannot be done, to stop emergency bleeding They are very useful products. However, the most important The disadvantages are complex structure and high cost. they are.
Acil kanamali (subaraknoid beyin kanamalari, solunum sistemi kanamalari, gastrointestinal sistem. kanamalari, böbrek kanamalari, ekstremite kanamalari, vs.) hastalara müdahalede bu vasküler tikaçlar sikça kullanilmaktadir. Ancak yurtiçi üretim olmayisi ve disa bagimlilik, mevcut SUT (Saglik Uygulama Tebligi) fiyatlarinin malzeme alimi için yetersiz kalmasi nedeniyle ürün tedarikinde aksamalar meydana gelmektedir. patent dokümani verilebilir. Söz konusu doküman kan damarlarinin tikanmasi için gelistirilen biyoemilebilir ya da biyouyumlu bir malzemeden olusan bir tikaci konu almaktadir. Immediate hemorrhage (subarachnoid cerebral hemorrhages, respiratory system bleeding, gastrointestinal tract. bleeding, kidney bleeding, extremity bleeding, etc.) these vascular plugs are frequently used. However, domestic lack of production and foreign dependency, existing HIN (Health Implementation Notice) prices are insufficient for material purchase. disruptions in product supply due to is coming. patent document can be granted. The document in question bioabsorbable or It is about a plug made of a biocompatible material.
Bahsedilen tikaç iç kanamanin ve anevrizmanin tedavisinde veya bir tümöre kanin akisini baskilamak için kullanilabilmektedir. Söz konusu tikaç/koil en genel haliyle, biyoemilebilir bir polimerden sekillendirilerek olusturulan, son haliyle içi bos helezonik bir Hwno-filamenttir. Tikaç, kan damarinin istenilen bölgesine bir kateter araciligi ile serbestlenmekte ve sekil hafizasina sahip olmasi sebebiyle itildikten sonra da son seklini koruyabilmektedir. Söz konusu ürünün iç çapi 0.12 mm' dir. içerisindeki bosluktan, üretilmis inch=0.36 mm) geçemeyecektir. Dolayisiyla bu tikacin sadece mikrokateterin iç boslugundan kilavuz tel ile itilerek istenilen damar lümenine serbestlestirildigi anlasilmaktadir. The aforementioned plug is used in the treatment of internal bleeding and aneurysm. or to suppress blood flow to a tumor can be used. The plug/coil in question is, in its most general form, formed from a bioabsorbable polymer, in its final form it is a hollow helical Hwno-filament. Plug, via a catheter to the desired area of the blood vessel being released and having shape memory It can maintain its final shape even after being pushed. Aforementioned The inner diameter of the product is 0.12 mm. produced from the emptiness inside inch=0.36 mm). Therefore, this plug is only by pushing the guide wire through the inner cavity of the microcatheter. It is understood that it is released into the desired vessel lumen.
Bulusun bir yapilandirmasinda, koilin bosluguna karsinostatik, anti tümör ajan yerlestirilebilmektedir. In one embodiment of the invention, the gap of the coil A carcinostatic, anti-tumor agent can be placed.
Teknigin bilinen durumuna baska bir örnek olarak USS423849A sayili patent dokümani verilebilir. Söz konusu doküman kan damarlarinin tikanmasi ve kanamanin durdurulmasi için radyo- opak liflerin örülmesi ile elde edilen tüp seklinde bir damar tikayici cihazi konu almaktadir. Dokümana konu damar tikayici cihaz tüp seklinde lümenli (bosluklu) olup, istenilen bölgeye bir kateter araciligi ile serbestlenmektedir. Söz konusu ürün 0.0005-0.005 inch kalinlikta fiberlerden örülmüs tercihen 0.0l5-0.018 inch çapta tikaçlardir. Iç bosluklarinda bir fitil ya da fibröz merkez bulunmaktadir. USS423849A as another example of the state of the art patent document no. The document in question radiotherapy to block blood vessels and stop bleeding. a tube-shaped vessel obtained by knitting opaque fibers It is about the occlusive device. Vascular occlusive subject to the document The device is in the form of a tube with a lumen (space) and can be placed on the desired area. is released through a catheter. The product in question Preferably knitted from 0.0005-0.005 inch thick fibers 0.0l5-0.018 inch diameter plugs. one in the inner cavities There is a wick or fibrous center.
USZOO4098023A. sayili dokümanda. ise damar` içerisinde kanin akisinin durdurulmasi için gelistirilen bir tikayici cihazi konu alinmaktadir. Bahsedilen dokümana konu tikayici cihaz en genel haliyle, bir merkez yapi ve bunun üzerine ilistirilmis nano-fiberlerden üretilmis bir fibröz yapi içermektedir. USZOO4098023A. in document no. canine in the vein An occlusive device developed to stop the flow subject is taken. The occlusive device subject to the mentioned document is the most In general, a central structure and its attached It contains a fibrous structure made of nano-fibers.
Teknigin bilinen durumuna baska bir örnek olarak US9060777Bl sayili doküman verilebilir. Söz konuSu doküman anevrizmalarin tedavi edilmesi için gelistirilen bir damar tikayici cihazi konu alan bir patent dokümanidir. Bahsedilen dokümana konu cihaz en genel haliyle; uzun ince metal malzemeden üretilmis tel bir merkez ve bunun üzerine proksimalden ilistirilen; 0.001 inch ya da daha ince çapli metalik malzemeden (nitinol) örülerek üretilmis, 6-10 cm uzunlukta, serbestlendiginde genisleyerek 2 mm çapa ulasabilen, tübüler bir dis elemandan olusmaktadir. Dokümanda söz konusu damar tikayici cihazini olusturan unsurlarin tümünün veya bir kisminin biyoemilebilir ve/veya biyoçözünür malzemeden olusabilecegi belirtilmektedir. Söz konusu tikayici cihazin distali (yani damar içerisine ilk salinan uzak ucu kilavuz tel ile ilisik degil aksine serbesttir), proksimali (yani damar içerisine en son salinan yakin ucu) ise geri toplayabilmeyi saglayacak sekilde kilavuz tele ilisiktir. Tikaç anevrizma içine itilerek nihayi konumunu tamamlamadan istenildigi taktirde kateter içerisine tekrar alinabilen kompleks bir yapiya sahiptir. Kullanim amaci kanayan damarlarin durdurulmasindan ziyade anevrizmal bosluklarin doldurulmasi ve tedavisidir. US9060777Bl as another example of the state of the art number of documents can be given. The aforementioned document is about aneurysms. An atherosclerosis device developed to treat It is a patent document on the subject. The subject of the mentioned document the device in its most general form; made of long thin metal material a wire center and proximally attached to it; Metallic material (nitinol) with a diameter of 0.001 inch or less knitted, 6-10 cm long, when released It consists of a tubular outer element that can expand to reach a diameter of 2 mm. is formed. The aforementioned atherosclerosis device in the document Bioabsorbable of all or some of the constituents and/or biodegradable material. is indicated. distal of the occlusive device in question (i.e. The distal end first released into the vessel is connected to the guide wire. on the contrary, it is free), proximal (that is, the most intravascular the last oscillating near end) will provide recovery In the figure, the guide is attached to the wire. Plug into aneurysm if desired without completing its final position by being pushed It has a complex structure that can be reintroduced into the catheter. has. The purpose of use is to stop bleeding veins. rather, it is the filling and treatment of aneurysmal spaces.
Yukarida verilen teknigin bilinen durumuna alternatif olarak, kateter içine rahat sevkedilebilmesi ve kateter içerisinde rahat ilerletilebilmesi için ön ucu sivri ve gövdesi silindirik, sert ve yekpare olan bir vasküler tikaç gelistirilmistir. Gelistirilen. bu vasküler' tikaç kan damarlarinin tikanmasi ve kanamanin durdurulmasi için mikrokateter lümeninden kilavuz tel vasitasiyla itilerek kullanilan, ön ucu sivri, gövde kismi silindirik, arka ucu firçamsi olmak üzere kisa, düz ve bosluksuz iskelet yapisina sahip, kolay uygulanabilir, etkili ve düsük maliyetlidir. As an alternative to the state of the art given above, it can be easily transferred into the catheter and inside the catheter Its front end is pointed and its body is pointed for easy advancement. a cylindrical, rigid, and solid vascular plug developed. developed. this vascular plug of blood for blocking blood vessels and stopping bleeding pushing through the lumen of the microcatheter through the guide wire. used, pointed front end, body part cylindrical, rear end It has a short, flat and gapless skeletal structure, being brushy. It is easy to apply, effective and low cost.
Bulusun Detayli Açiklamasi Bulus, özellikle girisimsel radyoloji alaninda kan damarlarinin tikanmasi ve kanamanin durdurulmasi için kullanilan vasküler tikaca (l) iliskindir. Detailed Description of the Invention The invention is particularly relevant in the field of interventional radiology. for blocking blood vessels and stopping bleeding It is related to the vascular plug (l) used.
Bulusun bir amaci etkili ve düsük maliyetli, mevcut ticari embolizan mikro-partiküller ile koiller arasindaki ihtiyaç ve görev boslugunu doldurabilecek vasküler tikaçlarin (l) gelistirilmesidir. An object of the invention is to provide effective and low-cost, available commercial between the embolizing micro-particles and the coils, and of vascular plugs that can fill the task gap (l) is to be developed.
Bulusa konu vasküler tikaç (l), mevcut ticari koillerin rutin endovasküler uygulamalarina benzer sekilde kullanilir. Buna göre Hßkrökateter (4) içerisinden ilerletilen mikrokateter (3) ve onun içerisinden bir kilavuz tel (2) ile itilen vasküler tikaç (l), arzu edilen damar lümeninde (5) serbestlenir. Böylelikle kan akisi engellenir ve ilgili damarin tikanmasi saglanir. The vascular plug (I) of the invention is a routine replacement for existing commercial coils. It is used similarly to endovascular applications. This The microcatheter advanced through the Hßkröcatheter (4) according to (3) and a guide wire (2) through it vascular plug (1) in the desired vessel lumen (5) is released. Thus, blood flow is prevented and the related occlusion of the vein is provided.
Biyoemilimli (biyoçözünür) ya da biyouyumlu mikrofibriller arzu edilen Çaplarda monofilament iplik halinde bir araya getirilir, biyouyumlu yapiskanlar(adhesive) ile ön ucu sertlestirilir. Kisa (O.5-l.5 cm), bosluksuz ve düz bir iskelet yapisi elde edilir. Bu sekilde X isini altinda (skopi, anjiyografi ünitesi) da görülebilmesi saglanir. Tikaç yapisinin mikrokateter (3) içinde önde ilerleyen uç kismi sivri, gövde kesimi yekpare (monofilament) ve silindirik, kilavuz tel (2) ile itilen arka ucu(6) damar lümeninde (5) serbestlendiginde genisleyebilecek sekilde ayrisabilen mikrofibriller sayesinde firçamsidir. Bu haliyle tikaç, mikrokateterin (3) hasta disinda kalan proksimal hub kesiminden enjekte edilen yüksek basinçli sivi jeti (serum fizyolojik vs. gibi) ile de serbestlenebilir. Tikacin çapi, uygulamada rahatlik için birlikte kullanilacagi mikrokateterin (3) iç lümen çapindan küçük seçilir. Üretilmis mikrokateterlerin (3) iç lümen çapi 0.0l5 inch:0.38 mm ile 0.028 inch:0.7l mm arasinda degismektedir. Bioabsorbable (biodegradable) or biocompatible microfibrils combined into monofilament yarn in desired diameters. front end with biocompatible adhesives is hardened. A short (0.5-1.5 cm), hollow and straight skeletal structure is obtained. In this way, under X-ray (scopy, angiography unit) can also be seen. Plug the anterior end of the structure in the microcatheter (3) pointed, body cut is monofilament and cylindrical, the posterior end (6) pushed by the guide wire (2) in the vessel lumen (5) decomposable to expand when released It is brushy thanks to microfibrils. In this form, the plug the proximal hub of the microcatheter (3) outside the patient high-pressure liquid jet (serum physiological vs. etc.) can also be released. The diameter of the plug, to be used together for convenience in application. smaller than the inner lumen diameter of the microcatheter (3). Produced with inner lumen diameter of microcatheters (3) 0.0l5 inch:0.38 mm It varies between 0.028 inch: 0.7l mm.
Bulusun bir yapilandirmasinda mikrofibriller poliglikolik asit, poliglaktik asit, polilaktik asit, poliglaktin, polidioksanon, politrimetilen karbonat, poliglekapron, glikomer, poligliton, poliglikonat, katgüt, kollajen, ipek, pamuk, keten vs. ya da bunlarin karisimini içermektedir. In one embodiment of the invention, microfibrillar polyglycolic acid, polyglactic acid, polylactic acid, polyglactin, polydioxanone, polytrimethylene carbonate, polyglecapron, glucomer, polygliton, polygluconate, catgut, collagen, silk, cotton, linen etc. or a mixture of these.
Bulusun bir yapilandirmasi radyo-opak kontrast madde kristalleri içeren siyanoakrilat türevi gibi biyouyumlu yapiskanlar içermektedir. One embodiment of the invention is radio-opaque contrast material. biocompatible, such as a cyanoacrylate derivative containing crystals Contains adhesives.
Tikacin ana formunda malzeme bileseni metal içermediginden MR görüntüleme için dezavantaj yaratmaz. Ancak tikacin varyatif bir formuna radyo-opasite özelligi kazandirmak ve damar boslugunda. sarmal form. alabilmesi için .nitinol inikrofiber eklenebilir. Bu sayede tikacin uzunlugunda ve damar lümeninde (5) aldigi nihayi sarmal formuyla tikayici islevinde artis da saglanabilir. In the main form of the plug, the material component does not contain metal, so the MR does not create a disadvantage for viewing. However, the tikacin variant to give a form of radio-opacity and in the void. spiral form. .nitinol inicrofiber can be added. In this way, the length of the plug and the vessel lumen (5) increases in its obstructive function with its final spiral form. can be provided.
Bu tip vasküler tikaç (1) anevrizmalarda kullanim için uygun degildir. Yalnizca kanamalarin durdurulmasi için kanayan damarin tikanmasi amaciyla gelistirilmistir. This type of vascular plug (1) is suitable for use in aneurysms. is not. Bleeding just to stop bleeding It has been developed for the purpose of occlusion of the vessel.
Bulusun bir yapilandirmasi teknikte bilinen ticari koiller ile ayni amaç (kanamanin durdurulmasi) için birlikte de kullanilabilir. One embodiment of the invention is commercial coils known in the art. together with for the same purpose (stopping bleeding) can be used.
Bulusa konu tikaç serbestlendiginde geri alinamaz. Once the subject plug is released, it cannot be recovered.
Bulusun bir yapilandirmasi bir makrokateterin (4) içerisinden geçen bir mikrokateterin (3) iç boslugundan bir kilavuz tel (2) ile itilerek damar lümeninde (5) serbestlenmek üzere, radyo-opak materyali haiz yekpare, ince, düz, kisa ve bosluksuz iskelet yapisina sahiptir. Iskelet yapisi, biyoemilimli ya da biyouyumlu mikrofibrillerin monofilament bir iplik haline getirilmesi ve bu ipligin biyouyumlu yapiskan malzemelerle sertlestirilmesi ile elde edilmekte ve böylelikle mikrökateter (3) iç boslugundan bir kilavuz tel (2) ile itilebilmektedir. Bahsedilen iskelet yapi sivri bir ön uç; ince, bosluksuz, kisa ve sert bir gövde; firçamsi formda serbest mikrofibriller içeren bir arka uç (6) içermektedir. Özetle bulus, kan damarlarinin tikanmasi ve kanamanin durdurulmasi için bir vasküler tikaç (l) olup, bir makrokateterin (4) içerisinden geçen bir mikrokateterin (3) iç boslugundan bir kilavuz tel (2) ile itilerek damar lümeninde (5) serbestlenmek üzere, biyoemilimli (biyoçözünür) ve/veya biyouyumlu mikrofibriller ve radyo-opak materyal içeren mcnöfilament bir iplik halinde sertlestirilmis, bir dogrultu boyunca uzanan, bosluksuz bir iskelet yapidadir. Bu iskelet yapi, mikrokateter (3) içinde önde ilerleyen, sivri bir ön uç, silindirik bir gövde ve kilavuz tel (2) ile itilen, damar lümeninde (5) serbestlendiginde genisleyen, firça seklinde serbest mikrofiberler içeren bir arka uç (6) içermektedir. One embodiment of the invention is through a macrocatheter (4). a guide wire through the inner cavity of a passing microcatheter (3) To be released in the vessel lumen (5) by pushing with (2), monolithic, thin, flat, short and It has a hollow skeletal structure. skeletal structure, monofilament of bioabsorbable or biocompatible microfibrils spinning into a thread and making this thread into a biocompatible adhesive obtained by hardening with materials and thus, a guide wire from the inner cavity of the microcatheter (3) It can be pushed with (2). The mentioned skeletal structure is a pointed thirteen; a thin, hollow, short and rigid body; brushy a posterior end (6) containing free microfibrils in the form contains. In summary, the invention is related to the prevention of occlusion of blood vessels and bleeding. a vascular plug (1) for a microcatheter (3) passing through the macrocatheter (4) the vessel by pushing with a guide wire (2) from its inner cavity. bioabsorbable (biodegradable) to be released in its lumen (5) and/or biocompatible microfibrils and radio-opaque material containing mcnöfilament stiffened into a thread, a It has a gapless skeletal structure extending along the line. This skeletal structure, protruding in the microcatheter (3), pointed propelled by a front end, a cylindrical body and a guide wire (2), brush that expands when released in the vessel lumen (5) a rear end (6) containing free microfibers in the form of contains.
Bulusun bir yapilandirmasi monofilament ipligin sertlestirilmesi için biyouyumlu yapiskan içermektedir. One embodiment of the invention is monofilament yarn. Contains biocompatible adhesive for hardening.
Bulusun bir yapilandirmasinin uzunlugu O.5-l.5 cm arasindadir. The length of one embodiment of the invention is 0.5-1.5 cm are in between.
Bulusun bir yapilandirmasi damar boslugunda sarmal form alabilmesi için nitinol mikrofiber içermektedir. One embodiment of the invention is the spiral form in the vasculature. Contains nitinol microfiber
Bulusun bir yapilandirmasinin mikrokateter (3) içinde çapi 0.028 inch:0.7l mm'den azdir. Diameter of one embodiment of the invention within the microcatheter (3) Less than 0.028 inch:0.7l mm.
Sekillerin Açiklamalari Sekil 1: Bulusa konu vasküler tikacin kateterler ve kilavuz tel aracili hedef damar lümeni içerisinde serbestlestirilmesine ait görünüm Sekil 2: Bulusa konu vasküler tikacin perspektif görünümü Sekil 3: Bulusa konu vasküler tikacin arka ucunun görünümü Sekillerde Yer Alan Referans Numaralarinin AçiklamalariDescriptions of Figures Figure 1: Catheters and guide of the vascular plug of the invention wire-mediated within the target vessel lumen view of liberalization Figure 2: Perspective view of the vascular plug of the invention Figure 3: View of the posterior end of the vascular plug of the invention Explanations of Reference Numbers in the Figures
Claims (1)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2020/15642A TR202015642A2 (en) | 2020-10-01 | 2020-10-01 | VASCULAR CLAMP |
| PCT/TR2021/050996 WO2022071911A1 (en) | 2020-10-01 | 2021-09-30 | Vascular plug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2020/15642A TR202015642A2 (en) | 2020-10-01 | 2020-10-01 | VASCULAR CLAMP |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR202015642A2 true TR202015642A2 (en) | 2020-10-21 |
Family
ID=75526264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2020/15642A TR202015642A2 (en) | 2020-10-01 | 2020-10-01 | VASCULAR CLAMP |
Country Status (2)
| Country | Link |
|---|---|
| TR (1) | TR202015642A2 (en) |
| WO (1) | WO2022071911A1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792154A (en) * | 1996-04-10 | 1998-08-11 | Target Therapeutics, Inc. | Soft-ended fibered micro vaso-occlusive devices |
| EP0882428A3 (en) * | 1997-06-05 | 2000-06-14 | Medtronic Ave, Inc. | Intravascular occlusion device |
| US6656200B2 (en) * | 2000-04-07 | 2003-12-02 | Collagen Matrix, Inc. | Embolization device |
| US9192389B2 (en) * | 2013-03-13 | 2015-11-24 | Cook Medical Technologies Llc | Occluding device and method of manufacturing occluding devices |
-
2020
- 2020-10-01 TR TR2020/15642A patent/TR202015642A2/en unknown
-
2021
- 2021-09-30 WO PCT/TR2021/050996 patent/WO2022071911A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022071911A1 (en) | 2022-04-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4211888B2 (en) | Embolization device that can be strengthened in situ | |
| JP2620530B2 (en) | Ultra-soft embolic device and method of use | |
| US6629947B1 (en) | Systems and methods for delivering flowable substances for use as implants and surgical sealants | |
| US6258055B1 (en) | System for implanting a cross-linked polysaccharide fiber and methods of forming and inserting the fiber | |
| US7309345B2 (en) | Method and system for delivering an implant utilizing a lumen reducing member | |
| US7128736B1 (en) | Detachable aneurysm neck closure patch | |
| JP4364119B2 (en) | Foldable vascular occlusion member | |
| US8267955B2 (en) | Metallic coils enlaced with fibers for embolization of a body cavity | |
| US20190374227A1 (en) | Polymeric Electrospun Embolization Device and Methods of Use | |
| JP2006506171A (en) | Embolization device made of nanofiber | |
| CA2504450A1 (en) | Detachable aneurysm neck bridge | |
| US20060167489A1 (en) | Vasoocclusive article | |
| US6589199B1 (en) | System for implanting a cross-linked polysaccharide fiber and methods of forming and inserting the fiber | |
| US20050283182A1 (en) | Systems and methods for intraluminal delivery of occlusive elements | |
| US20090163945A1 (en) | Polymeric slotted tube coils | |
| TR202015642A2 (en) | VASCULAR CLAMP | |
| US20160346423A1 (en) | Cyanoacrylate compositions including non-agglomerating radiopaque nanoparticles | |
| Hara et al. | Transarterial embolization of cerebrospinal lesions with liquid coils | |
| Tuite et al. | Coils, Occluders, and Plugs |