TR202015222A2 - In-vivo blood group identification device and method of use - Google Patents
In-vivo blood group identification device and method of use Download PDFInfo
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- TR202015222A2 TR202015222A2 TR2020/15222A TR202015222A TR202015222A2 TR 202015222 A2 TR202015222 A2 TR 202015222A2 TR 2020/15222 A TR2020/15222 A TR 2020/15222A TR 202015222 A TR202015222 A TR 202015222A TR 202015222 A2 TR202015222 A2 TR 202015222A2
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- 210000004369 blood Anatomy 0.000 title claims abstract description 44
- 239000008280 blood Substances 0.000 title claims abstract description 44
- 238000000034 method Methods 0.000 title claims abstract description 18
- 238000001727 in vivo Methods 0.000 title claims abstract description 14
- 238000001514 detection method Methods 0.000 claims abstract description 15
- 238000010521 absorption reaction Methods 0.000 claims description 5
- 238000001228 spectrum Methods 0.000 description 9
- 210000000601 blood cell Anatomy 0.000 description 8
- 210000003743 erythrocyte Anatomy 0.000 description 8
- 238000013186 photoplethysmography Methods 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 238000000862 absorption spectrum Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000000411 transmission spectrum Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 206010034912 Phobia Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000013528 artificial neural network Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 230000001427 coherent effect Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 208000019899 phobic disease Diseases 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/681—Wristwatch-type devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6822—Neck
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6824—Arm or wrist
Abstract
Bu buluş, kan gruplarının Rh faktörü ile birlikte in-vivo ve non-invazif olarak tespit edilmesinde kullanılan in-vivo kan grubu tanımlayıcı cihaz ve kullanım yöntemi ile ilgili olup, özelliği; 300 - 580 nanometre (nm) dalga boyu aralığında görünür bölge ışınlarını yayan ışık kaynağı (1), ışık kaynağı (1) tarafından iletilen ışının kan grubu farkına göre farklı miktarda absorbe olması veya saçılması ile elde edilen farklı genlik ve miktardaki yansıyan ışınların iletildiği algılayıcı modül (2), algılayıcı modüle (2) gelen ışınların genlik farkı ve geçen ışın miktarının farklılıklarından yararlanarak kan grubunun belirlendiği tespit modülü (3), en bir adet ışık kaynağı (1), algılayıcı modül (2) ve tespit modülünü (3) içeren portatif cihaz (4) ve portatif cihaza (4) konumlandırılmış ve kan grubu bilgilerinin kullanıcıya gösterildiği dijital ekrandan (5) meydana gelmesidir.The present invention relates to the in-vivo blood group identifier device and its method of use used for in vivo and non-invasive determination of blood groups together with Rh factor. The light source (1) emitting visible area rays in the wavelength range of 300 - 580 nanometers (nm), the light source (1) absorbed or scattered different amounts of the light transmitted by the difference in blood group, the sensor module where the reflected rays of different amplitude and amount are transmitted. (2), a portable device containing the detection module (3), at least one light source (1), the sensor module (2) and the detection module (3), where the blood group is determined by making use of the differences in the amplitude of the rays coming to the sensor module (2) and the amount of the passing beam. It consists of a digital display (5) positioned on the device (4) and the portable device (4) and showing the blood group information to the user.
Description
TARIFNAME IN-VIVO KAN GRUBU TANIMLAYICI CIHAZ VE KULLANIM YÖNTEMI Teknolojik Alan: Bu bulus, kan gruplarinin Rh faktörü ile birlikte in-vivo ve non-invazif olarak tespit edilmesinde kullanilan in-vivo kan grubu tanimlayici cihaz ve kullaniin yöntemi ile Teknigin Bilinen Durumu: Günümüzde insanlarin sicaklik, kan oksijen seviyeleri, solunum hizi, bagi] kan basinci gibi yasamsal bulgulari genel olarak bir veya daha fazla alet kullanilarak periyodik olarak izlenebilinektedir. Örnegin bir hastanin hayati degerlerini elde etmek için kullanilan aletler arasinda kan basinci ölçüm cihazlari, termometreler, SpO2 ölçüm cihazlari, glikoz seviye ölçerler bulunmaktadir. Bu izleme aletlerine ek olarak önemli bir etken olan hastalarin kan gruplarinin tespiti bir igne ve siringa kullanilarak halen antikorlardan faydalanarak in-vitro yöntemler ile gerçeklestirilmektedir. Kan örnegi daha sonra analiz için bir laboratuvara tasinmakta ve tespit islemi invaziv olarak belirlenmektedir. Bu da antijen bagimli in-vitro ölçümlerde, ölçüm için kan alinmasi, igne fobisi olanlar için istenmeyen bir durumdur. Ayrica antikor kullanilmasi ve her ölçümde farkli lamel kullanimi ek maliyet gerektirmektedir. Bu nedenle bu tür yöntemler hem zaman almakta hem de maliyetli bir islem olmaktadir. Hastalar için hayati öneme sahip olan kan gruplarinin invaziv olmayan tekniklerle belirlenmesini saglayan bir yönteme ihtiyaç olmaktadir. Bu amaçla gelistirilen ve literatürde var olan buluslar ve yetersiz kalinan noktalari asagida açiklanmistir. DESCRIPTION IN-VIVO BLOOD GROUP IDENTIFICATION DEVICE AND METHOD OF USE Technological Field: This invention is an in-vivo and non-invasive detection of blood groups together with the Rh factor. with the in-vivo blood group identifying device and method of use State of the Art: Today, people's temperature, blood oxygen levels, respiratory rate, blood pressure Periodic observations of vital signs, such as can be tracked. For example, to obtain the vital values of a patient Among the instruments used are blood pressure measuring devices, thermometers, SpO2 measurement devices, glucose level meters. In addition to these monitoring tools, important determination of the blood groups of patients with a causative agent is still still possible using a needle and syringe. It is carried out by in-vitro methods using antibodies. blood sample It is then transported to a laboratory for analysis and the detection process is performed invasively. is determined. This means that in antigen-dependent in-vitro measurements, taking blood for measurement, It is undesirable for those with needle phobia. In addition, the use of antibodies and each The use of different coverslips in measurement requires additional costs. Therefore this kind methods are both time-consuming and costly. for patients determination of vital blood groups by non-invasive techniques A convincing method is needed. Developed for this purpose and existing in the literature Inventions and failing points are explained below.
WO201916141 lAl yayin numarali patent basvurusunda “Sinir Agini Kullanarak Saglik Verilerini Alma Sistem Ve Yöntemi” açiklanmistir. Mevcut bulusta bir fotopletismografi (PPG) devresi veya temassiz kamera, çok sayida dalga boyunda PPG sinyallerini almaktadir. Bir sinyal isleme modülü, bir birinci dalga boyu çevresinde en az bir birinci spektral tepki ve bir ikinci dalga boyu çevresinde ikinci bir spektral tepki elde etmektedir. Sinyal isleme cihazi, PPG sinyallerini kullanarak PPG giris verilerini üretmekte ve burada PPG giris verileri, birinci spektral yanitin ve ikinci spektral yanitin her birinden elde edilen bir veya daha fazla parametre içermektedir. Bir nöral ag isleme cihazi, PPG giris verilerini içeren bir girdi vektörü olusturur ve saglik verilerini içeren bir çikti vektörünü belirler; bu sekilde bulus burada oksijen doygunluk seviyesi, bir glikoz seviyesi veya bir kan alkol seviyesi gibi saglik verilerini belirlemektedir. In the patent application with publication number WO201916141 lAl, “Health Using Neural Network” Data Retrieval System and Method” is explained. In the present invention, a photoplethysmography (PPG) circuit or contactless camera, multi-wavelength PPG receives signals. A signal processing module is a first wavelength at least a first spectral response and a second spectral response around a second wavelength achieves. The signal processor uses PPG signals to output PPG input data. generates the PPG input data, where the first spectral response and the second spectral response contains one or more parameters obtained from each. Processing a neural network device creates an input vector containing PPG input data and determines an output vector; so the invention here is the oxygen saturation level, a It determines health data such as glucose level or a blood alcohol level.
CN1399131A yayin numarali patent basvurusunda “Yarasiz Kan Hücresi Parametre Ölçüm Yöntemi” açiklanmistir. Mevcut bulus yarasiz kan hücresi parametresi kantitatif tayin yöntemi ile ilgili olup, optik koherent tomografik (OCT) görüntüleme teknolojisini benimsemektedir. Yöntemde canli vücut dokundaki kan damari, lokal odaklarna ve görüntü infüzyon rekonstrüksiyonu için farkli derinlikte genis bant lazer kaynagi ile aydinlatilir, damarin farkli tomografik derinliginde çesitli kan hücrelerinin 3-D OCT görüntüleri elde edilir. OCT görüntülerinin analizi ve hesaplanmasiyla, karakteristik 3-B yapi bilgisi ve eritrosit, lökosit ve kan trombositi de dahil olmak üzere karsilik gelen kan hücrelerinin niceliksel karakteristigi ve parametreleri elde edilmektedir. In the patent application with publication number CN1399131A, “Woundless Blood Cell Parameter Measurement Method” is explained. The present invention woundless blood cell parameter quantitative It is related to the detection method and uses optical coherent tomographic (OCT) imaging technology. adopts. In the method, blood vessels in living body tissue, local foci and with a wideband laser source at different depths for image infusion reconstruction illuminated, 3-D OCT of various blood cells at different tomographic depth of the vessel images are obtained. With the analysis and calculation of OCT images, characteristic 3-D structural information and the corresponding quantitative characteristics and parameters of blood cells are obtained.
US4070113A yayin numarali patent basvurusunda “Tutarli Optik Kan Hücresi Siniflandirma Sistemi” açiklanmistir. Mevcut bulusta çesitli ana kan hücresi tiplerini siniflandirmak için bir sistem saglanmistir. Burada kan hücreleri bir lazer isini öncesinde geçirilir. Hücreden geçen yeniden yönlendirilen isik enerjisi, nesnenin uzamsal iliskilerini temsil eden bir voltaj spektrumu saglayan bir detektör dizisine uygulanir. Bu voltaj spektrumu, farkli kan hücresi siniflarini temsil eden farkli spektrumlarla hizla karsilastirilir. Karsilastirma araci tarafindan en iyi uyum tespit edildiginde, hücre siniflarindan birinde bir sayi puanlanir. Ayni araç, kanser ve pul pul dökülmüs hücreler gibi diger hücre tiplerinin analizi için de geçerlidir. In the patent application with publication number US4070113A, “Coherent Optical Blood Cell Classification System” is explained. Various major blood cell types are described in the present invention. A system is provided for classification. Here, the blood cells emit a laser beam. passed beforehand. Redirected light energy passing through the cell to a detector array that provides a voltage spectrum representing their spatial relationships. is applied. This voltage spectrum is divided into different classes representing different blood cell classes. are quickly compared with the spectra. Best fit detected by comparison tool is scored, a number is scored in one of the cell classes. The same tool, cancer and flakes This also applies to the analysis of other cell types, such as shed cells.
Yukarida ele alinan basvurularda kari hücresinin siniflandirilmasinda kullanilan in vivo yöntemlerle siniflandirma islemi yapilmaktadir. Ancak mevcut buluslarda kan grubunu belirlenmesini saglayan bir sistemin bileklik gibi herhangi bir portatif aksesuara entegre edilmis sekline rastlanmamistir. Sadece saglik verileri izlenmekte ve acil bir durum oldugunda müdahale edilmesini amaçlamaktadirlar. Ayrica bu yönteinlerde önerilen in- vivo kan tanimlayicilar arasinda kullanilan led isigin dalgaboyu farklilik göstermektedir. In vivo, which is used in the classification of the frontal cell in the applications discussed above. Classification is done by methods. However, in the present inventions, the blood group integrated into any portable accessory, such as a wristband. no form was found. Only health data is monitored and an emergency They aim to intervene when it happens. In addition, the recommended in- The wavelength difference of the led light used between in vivo blood identifiers shows.
Sonuç olarak yukarida bahsedilen dezavantajlarin üstesinden gelebilen, in-vivo olarak kan grubunu tespit eden, portatif bir sekilde akilli bileklik, akilli saat, kolye veya kizilötesi termometre gibi temassiz olarak kullanilabilen, kullanimi kolay, maliyeti az, birden fazla kisi tarafindan defalarca kullanilan yeni bir teknolojiye ihtiyaç duyulmaktadir. As a result, it can be used in-vivo, which can overcome the above-mentioned disadvantages. a portable smart bracelet, smart watch, necklace or It can be used non-contactly like an infrared thermometer, easy to use, low cost, need for a new technology that is used repeatedly by more than one person. is heard.
Bulusun Tanimi: Bu bulus, in-Vivo kan grubu tanimlayici cihaz ve kullanim yöntemi olup, özelligi; in- vivo olarak kan grubunu tespit eden, portatif bir sekilde akilli bileklik, akilli saat, kolye veya kizilötesi termometre gibi temassiz olarak kullanilabilen, kullanimi kolay, maliyeti az, birden fazla kisi tarafindan defalarca kullanilan yeni bir teknoloji olmasidir. Description of the Invention: This invention is an in-vivo blood group identifying device and method of use, and its features are; of- Portable wristband, smart watch, necklace that detects blood group in vivo or an infrared thermometer that can be used non-contact, easy to use, cost effective What's less is that it's a new technology that has been used over and over by more than one person.
Yukarida bahsedilen ve asagida da detayli anlatimdan ortaya çikacak tüm amaçlari gerçeklestirmek üzere bulus; kan gruplarini Rh faktörü ile birlikte in-vivo ve non- invazif olarak tespit edebilmektedir. All the purposes mentioned above and which will emerge from the detailed description below. invention to realize; blood groups together with Rh factor in-vivo and non- can be detected invasively.
Bulus konusu cihaz akilli bileklik, akilli saat, kolye veya kizilötesi termometre gibi temassiz olarak kullanilabilmektedir. Bu sayede herhangi bir cerrahi isleme gerek kalmadan hastalarin kan gruplari belirlenmektedir. Bulus konusu cihaz ile igne fobisi olan bireylerin rahat bir sekilde kan gruplari saniyeler içerisinde belirlenmektedir. The device of the invention is such as a smart bracelet, smart watch, necklace or infrared thermometer. can be used without contact. In this way, no surgical operation is required. The blood groups of the patients are determined without Needle phobia with the inventive device The blood groups of the individuals with diabetes are easily determined in seconds.
Ayrica kullanilan Cihazin portatif olmasi da birden fazla kisi de kullanim kolayligi saglamakta ve bu sekilde maliyetten de tasarruf edilmektedir. In addition, the device used is portable and it is easy to use for more than one person. and thus saves costs.
Bulus konusu yöntemin tüm avantajlari asagida verilen sema ve bu semaya atiflar yapmak suretiyle yazilan detayli açiklama sayesinde daha net anlasilacaktir ve bu nedenle degerlendirme de bu sema ve detayli açiklama göz önünde bulundurularak yapilinasi gerekmektedir. All the advantages of the method of the invention refer to the diagram given below and to this diagram. It will be understood more clearly thanks to the detailed explanation written by For this reason, the evaluation was made by taking this diagram and detailed explanation into consideration. needs to be done.
Sekillerin Açiklanmasi: Bulus, ilisikteki sekillere atifta bulunularak anlatilacaktir, böylece bulusun özellikleri daha açikça anlasilacak ve takdir edilecektir, fakat bunun amaci bulusu bu belli düzenlemeler ile sinirlamak degildir. Tam tersine, bulusun ilisikteki istemler tarafindan tanimlandigi alani içine dahil edilebilecek bütün alternatifleri, degisiklikleri ve denkliklerinin kapsanmasi amaçlanmistir. Gösterilen ayrintilar, sadece mevcut bulusun tercih edilen düzenlemelerinin anlatimi amaciyla gösterildigi ve hem yöntemlerin sekillendirilmesinin, hem de bulusun kurallari ve kavramsal özelliklerinin en kullanisli ve kolay anlasilir tanimini saglamak amaciyla sunulduklari anlasilmalidir. Bu çizimlerde; Sekil 1 Bulus konusu cihazin örnek bir düzenlemesinin görünümüdür. Explanation of Figures: The invention will be described with reference to the accompanying figures so that the features of the invention will be more clearly understood and appreciated, but the purpose of this It's not about limiting yourself with regulations. On the contrary, the invention is satisfied by the appended claims. all alternatives, changes and It is intended to cover the equivalences. Details shown are available only. shown for illustration of preferred embodiments and both methods formulation, as well as the rules and conceptual features of the invention. and it should be understood that they are presented to provide an easy-to-understand definition. This in drawings; Figure 1 is a view of an exemplary embodiment of the device of the invention.
Sekil 2 Bulus konusu cihazi olusturan unsurlarin sematik görünümüdür. Figure 2 is the schematic view of the components of the inventive device.
Sekil 3a Elektromanyetik dalganin bir obj eden Rayleigh saçilmasi seklindeki görünümüdür. Figure 3a An object Rayleigh scattering of electromagnetic wave. is the view.
Sekil 3b Elektromanyetik dalganin bir objeden Mie saçilmasi seklindeki görünümüdür. Figure 3b Mie scattering of electromagnetic wave from an object is the view.
Sekil 4a Tam kan numunesinin in-vitro transmisyon spektrumu Sekil 4b Tam kan numunesinin in-vitro absorbsiyon spektrumu Sekil Sa Eritrosit numunesinin in-vitro transmisyon spektrumu Sekil Sb Eritrosit numunesinin in-Vitro absorbsiyon spektrumu Bu bulusun anlasilmasina yardimci olacak sekiller ekli resimde belirtildigi gibi numaralandirilmis olup isimleri ile beraber asagida verilmistir. Figure 4a In-vitro transmission spectrum of whole blood sample Figure 4b In-vitro absorption spectrum of whole blood sample Figure Sa In-vitro transmission spectrum of the erythrocyte sample Fig. In-Vitro absorption spectrum of Sb Erythrocyte sample Figures to assist in understanding this invention are as indicated in the attached picture. are numbered and given below with their names.
Referanslarin Açiklanmasi: Algilayici Modül Tespit Modülü Portatif Cihaz . Ekran Bulusun Açiklanmasi: Bulus, 300 - 580 nanometre (nm) dalga boyu araliginda görünür bölge isinlarini yayan isik kaynagi (l), isik kaynagi (1) tarafindan iletilen isinin kan grubu farkina göre farkli miktarda absorbe olmasi veya saçilmasi ile elde edilen farkli genlik ve miktardaki yansiyan isinlarin iletildigi algilayici modül (2), algilayici modüle (2) gelen isinlarin genlik farki ve geçen isin miktarinin farkliliklarindan yararlanarak kan grubunun belirlendigi tespit modülü (3), en az bir adet isik kaynagi (1), algilayici modül (2) ve tespit modülünü (3) içeren portatif cihaz (4) ve portatif cihaza (4) konumlandirilmis ve kan grubu bilgilerinin kullaniciya gösterildigi dijital ekrandan (5) meydana gelmektedir. Explanation of References: Sensor Module Detection Module Portable Device . Screen Description of the Invention: The invention emits visible region rays in the wavelength range of 300 - 580 nanometers (nm). The light source (l) differs according to the blood type difference of the light transmitted by the light source (1). different amplitude and amount obtained by absorption or scattering The sensor module (2) to which the reflected rays are transmitted, the rays coming to the sensor module (2) taking advantage of the differences in the amplitude difference and the amount of light transmitted, detection module (3), at least one light source (1), sensor module (2), and the portable device (4) containing the detection module (3) and positioned on the portable device (4) and consists of a digital screen (5) where blood group information is displayed to the user.
Bulus akilli bileklik veya akilli saat veya kolye veya kizilötesi termometre olarak kullanilinasi ile karakterize edilmektedir. Invention as a smart bracelet or smart watch or necklace or infrared thermometer characterized by its usability.
Bulus saçilan isinlarin algilanmasi saglayan algilayici modül (2) ve isik kaynaginin (l) yan yana veya belli bir açi yapacak sekilde konumlandirildigi portatif cihazi (4) içermektedir. The invention consists of the detector module (2) and the light source (l), which enables the detection of scattered rays. portable device (4) in which it is positioned side by side or at an angle contains.
Bulusun Detayli Açiklanmasi: Bulus konusu cihazin sahip oldugu temel unsurlar; isik kaynagi (1), algilayici modül (2) tespit modülü (3), portatif cihaz (4) ve dijital ekran (5) olmaktadir. Detailed Description of the Invention: The basic elements of the inventive device are; light source (1), sensor module (2) detection module (3), portable device (4) and digital display (5).
Bulus konusu cihazin çalisma prensibi su sekildedir: 300 - 580 nanometre (nm) dalga boyuna sahip görünür bölge isinlarini yayan isik kaynagi (1) içeren akilli bileklik, akilli saat, kolye veya kizilötesi termometre gibi temassiz olarak kullanilabilen bir portatif cihaz (4) yardimi ile uygulanmasi ve isinin kan eritrositlerinden kan grubu farkina göre farkli miktarda absorbe olmasi veya saçilmasi ile elde edilen isinin her kan grubu için belirleyici olmasindan faydalanarak kan grubu tespit edilmesi seklindedir. The working principle of the inventive device is as follows: 300 - 580 nanometer (nm) wave smart bracelet containing a light source (1) that emits visible rays with a neck a non-contact portable device such as a watch, necklace, or infrared thermometer. with the help of the device (4) and heat according to the blood group difference from the blood erythrocytes. For each blood group, the heat obtained by absorbing or scattering in different amounts It is in the form of determining the blood group by taking advantage of the fact that it is a determinant.
ABO kan gruplarinin eritrositleri birbirinden farkli antijenik yapiya sahip olmaktadir. The erythrocytes of ABO blood groups have different antigenic structures from each other.
Bu nedenle absorbsiyon spektrumunda 300 - 580 nm dalga boyu araliginda farkli genliklerde piklere sahip olmaktadir. Bu konusu cihaz ile genlik farki yardimi ile kan grubu belirlenmektedir. Absorbsiyon spektruinunun yani sira saçilma spektrumuna da bakildigi zaman kanin bilesenlerinin saçilma spektrumuna katkisi belirlenebilmektedir. Therefore, there are different wavelengths in the absorption spectrum between 300 and 580 nm. amplitudes have peaks. With this device, blood is collected with the help of amplitude difference. group is determined. In addition to the absorption spectrum, it also has the scattering spectrum. When viewed, the contribution of blood components to the scattering spectrum can be determined.
Buradaki saçilma Mie saçilmasi (Sekil-3b) olarak bilinen elektromanyetik dalganin dalga boyuna yakin büyüklükteki küresel objelerden saçilma olayidir. Sekil-4a ve Sekil-4b” den anlasilacagi gibi transmisyon ile kan grubu belirlenmesi: 300 - 580 nm dalga boyu araliginda bir isik kaynagi (1) kullanarak geçen isin miktarinin farkliliklarindan kan grubu belirlenebilniektedir. The scattering here is the scattering of the electromagnetic wave known as Mie scattering (Figure-3b). It is the phenomenon of scattering from spherical objects close to the wavelength. Figure-4a and As can be seen in Figure-4b, determination of blood group by transmission: 300 - 580 nm the amount of light transmitted using a light source (1) in the wavelength range blood group can be determined from the differences.
Bulus konusu Cihaz tarafindan kan numunelerinden isinin saçilmasi, absorbsiyon ve transmisyonu spektrumlari yardimi ile temassiz olarak kan numunelerinin gruplarinin tespiti saglanabilmektedir. Burada ölçülecek kan grubu ve örnek nuinunenin Fast Furier transform (F FT) metodu ile kiyaslanmasi yapilmistir. The subject of the invention is the scattering of heat from blood samples by the device, absorption and groups of blood samples without contact with the help of transmission spectra. detection can be achieved. The blood type and sample nuinune to be measured here are Fast Furier It was compared with the transform (F FT) method.
Bulus konusu cihaz ve teknik unsurlari: Teorik ve deneysel çalismalar neticesinde 300 - 580 nm araliginin bu amaçla kullanilabilecegi tespit edilmistir. Sekil-Sa ve Sekil-5b” den anlasilacagi üzere kan numunelerinin eritrosit süspansiyonlarinin spektrumu spektrofotometre yardimi ile alinmistir. Bu spektrumda tüm kan gruplarinin eritrosit süspansiyonlarinin 300 - 580 nm de birbirinden farkli absorbsiyon piki verdigi gözlemlenmistir. Böylece tam kan spektrumunda bu dalga boyu araliginda elde edilecek piklerin eritrositlerden oldugu kanisina varilmistir. Kirmizi kan hücresi 5-10 mikron büyüklügündedir. Fakat çevreleyen antijen kalinligi optik spektrumda saçilma ve absobsiyon degerini etkilemektedir. Saçilan isin absorbe olana göre büyük dalga boylu ve düsük enerjili olmaktadir. Saçilan isinlarin algilanmasi için algilayici modül (2) olarak görev yapan dedektör ve isik kaynagi (1) yan yana veya belli bir açi yapacak sekilde bulunmaktadir. Absorbe olanin ve transmisyon isin dedeksiyonu için dedektör ve isik kaynagi arasinda 1800 bulunmaktadir. Saçilan isigin dedektasyonu için maksimum pik veren açi belirlenmekte ve dedektör portatif cihaz (4) o kismina yerlestirilmektedir.Invention device and its technical elements: As a result of theoretical and experimental studies, 300 - It has been determined that the 580 nm range can be used for this purpose. Figure-Sa and Figure-5b” As can be seen from the spectrum of erythrocyte suspensions of blood samples taken with the help of a spectrophotometer. Erythrocytes of all blood groups in this spectrum suspensions give different absorption peaks at 300 - 580 nm. has not been observed. Thus, it will be obtained in this wavelength range in the whole blood spectrum. It was concluded that the peaks were from erythrocytes. Red blood cell 5-10 micron in size. However, the surrounding antigen thickness causes scattering in the optical spectrum and affects the absorption value. The scattered light has a larger wavelength than the absorbed one. and low energy. Sensor module (2) for detecting scattered rays The detector and the light source (1), which act as is in the tab. Detector for the detection of absorbent and transmission smoke and the light source is between 1800. For the detection of scattered light The maximum peaking angle is determined and the detector is connected to that part of the portable device (4). is placed.
Claims (3)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2020/15222A TR202015222A2 (en) | 2020-09-24 | 2020-09-24 | In-vivo blood group identification device and method of use |
| PCT/TR2021/050937 WO2022066126A1 (en) | 2020-09-24 | 2021-09-15 | In-vivo blood type identifying device and method of use |
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| Application Number | Priority Date | Filing Date | Title |
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| TR2020/15222A TR202015222A2 (en) | 2020-09-24 | 2020-09-24 | In-vivo blood group identification device and method of use |
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| US5791345A (en) * | 1993-09-03 | 1998-08-11 | Toa Medical Electronics Co., Ltd. | Non-invasive blood analyzer |
| US6330058B1 (en) * | 1999-04-14 | 2001-12-11 | University Of South Florida | Spectrophotometric method and apparatus for blood typing |
| US10039500B2 (en) * | 2015-09-25 | 2018-08-07 | Sanmina Corporation | System and method for blood typing using PPG technology |
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